CA2699627A1 - Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same - Google Patents

Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same Download PDF

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Publication number
CA2699627A1
CA2699627A1 CA2699627A CA2699627A CA2699627A1 CA 2699627 A1 CA2699627 A1 CA 2699627A1 CA 2699627 A CA2699627 A CA 2699627A CA 2699627 A CA2699627 A CA 2699627A CA 2699627 A1 CA2699627 A1 CA 2699627A1
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zirconium
carbonate
sodium
meq
zrp
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CA2699627C (en
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Raymond J. Wong
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Renal Solutions Inc
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/04Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
    • B01J20/043Carbonates or bicarbonates, e.g. limestone, dolomite, aragonite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A61M1/1696Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0211Compounds of Ti, Zr, Hf
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0274Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04 characterised by the type of anion
    • B01J20/0277Carbonates of compounds other than those provided for in B01J20/043
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0274Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04 characterised by the type of anion
    • B01J20/0292Phosphates of compounds other than those provided for in B01J20/048
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/06Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
    • B01J20/08Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04 comprising aluminium oxide or hydroxide; comprising bauxite
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbon; comprising carbon obtained by carbonising processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28052Several layers of identical or different sorbents stacked in a housing, e.g. in a column
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30Processes for preparing, regenerating, or reactivating
    • B01J20/32Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3234Inorganic material layers
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01GCOMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G25/00Compounds of zirconium
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01GCOMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G25/00Compounds of zirconium
    • C01G25/006Compounds containing, besides zirconium, two or more other elements, with the exception of oxygen or hydrogen
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/40Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/42Materials comprising a mixture of inorganic materials
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/50Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/62In a cartridge
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/60Particles characterised by their size
    • C01P2004/61Micrometer sized, i.e. from 1-100 micrometer
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00Physical properties of inorganic compounds
    • C01P2006/80Compositional purity
    • C01P2006/82Compositional purity water content

Abstract

A method of making sodium zirconium carbonate is described which involves forming a mixture of zirconium oxychloride with soda ash and then heating at a sufficient temperature and for a sufficient time to form the sodium zirconium carbonate. Subsequent washing and filtration steps can further form parts of the process. A novel sodium zirconium carbonate is further described which contains from about 2 wt% to about 5wt% Na+; from about 44 wt% to about 50 wt% ZrO2; from about 12 wt% to about 18 wt% CO3 2; and from about 30 wt% to about described which involve titrating an aqueous slurry of sodium zirconium carbonate to a pH of from about 3.5 to about 4.0 with an acidic agent wherein the sodium zirconium carbonate has a moisture content of form about 15% to about 25% LOD is solid form. The process further involves washing the aqueous slurry containing the formed zirconium basic carbonate with water. A novel zirconium basic carbonate is further disclosed which has a minimum adsorption capacity of from about 30 to about 35 mg/PO4-P/gm SZC; a minimum HCO3- content of from about 2 to about 4 mEq HCO3-gm/SZC; a leachable Na+ content of from about 1.5 to about 2.0 mEq Na+/gm SZC; and/or a pH range of titrated sodium zirconium carbonate of from about 6 to about 7. A method of making zirconium phosphate is also disclosed which involves treating sodium zirconium carbonate with caustic soda to from an alkaline hydrous zirconium oxide which is subsequently heated and mixed with phosphoric acid to obtain an acid zirconium phosphate which can be titrated with caustic soda to achieve the desired zirconium phosphate. Novel zirconium phosphates are also disclosed as well as uses for the above zirconium containing materials.

Claims (8)

1. A zirconium basic carbonate having:
Na+ of less than 1000ppm;

a ZrO2 wt% of from 35 wt% to 40 wt%;

and a CO3 2 - wt% of from 8 wt% to 10 wt%, based on the weight of the zirconium basic carbonate.
2. The zirconium basic carbonate of claim 1, wherein said zirconium basic carbonate contains less than 0.01 wt% SO4 2- and less than 0.01 wt% Cl-.
3. A dialysis cartridge comprising the zirconium basic carbonate of claims 1 or 2 and a zirconium phosphate having:

an H+ wt% of from 1.4 to 2.0 wt%;
an Na+ wt % of from 4 to 6%;

a ZrO2 wt% of from 34 wt% to 37wt%;

a PO4 3- wt% of from 41 wt% to 43 wt%; and an H2O wt% of from 14 wt% to 18 wt%, based on the weight of the zirconium phosphate.
4. The dialysis cartridge of claim 3 wherein said zirconium phosphate has at least one of the following characteristics:

(a) an adsorption capacity for ammonia of from 20 mg NH4 N/g ZrP to 45 mg NH4-N/g ZrP:

- an adsorption capacity of from 2 mEq Ca2+/g ZrP to 7 mEq CA2+/g ZrP

- an adsorption capacity of Mg2+ of from 3 mEq Mg2+ /g ZrP to 5 mEq Mg2+ /g ZrP; and - an adsorption capacity for toxic heavy metals of from 3 mEq HM/g ZrP to 9 mEq HM/g ZrP;

(b) an Na+ content of from 2 mEq Na+ /g ZrP to 3 mEq Na+ /g ZrP at a pH of from 5.5 to 6;

(c) a minimum leachable PO4 3- of less than 0.05 mg PO4 3- /g ZrP; or (d) satisfying ANSI/AAMI RD-5-1992 standard on extractable toxic impurities.
5. The dialysis cartridge of claims 3 or 4 wherein said zirconium phosphate has no residual sulfate or chloride.
6. The dialysis cartridge of any one of claims 3 to 5 wherein said zirconium phosphate has less than 0.01 % sulphate, chloride or both.
7. The dialysis cartridge of any one of claims 3 to 6 wherein said zirconium phosphate in H2O has a pH of from 6 to 7.
8. The dialysis cartridge of any one of claims 3 to 7 wherein said zirconium phosphate has an average grain size of from 30 to 40 µm (microns).
CA2699627A 2000-11-28 2001-11-28 Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same Expired - Lifetime CA2699627C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/723,396 US6627164B1 (en) 2000-11-28 2000-11-28 Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same
US09/723,396 2000-11-28
CA2427992A CA2427992C (en) 2000-11-28 2001-11-28 Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2427992A Division CA2427992C (en) 2000-11-28 2001-11-28 Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same

Publications (2)

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CA2699627A1 true CA2699627A1 (en) 2002-06-06
CA2699627C CA2699627C (en) 2012-03-06

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ID=24906071

Family Applications (4)

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CA002427985A Expired - Lifetime CA2427985C (en) 2000-11-28 2001-11-28 Cartridges useful in cleaning dialysis solutions
CA2699627A Expired - Lifetime CA2699627C (en) 2000-11-28 2001-11-28 Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same
CA2699334A Expired - Lifetime CA2699334C (en) 2000-11-28 2001-11-28 Dialysis cartridges comprising sodium zirconium carbonate and zirconium basic carbonate and methods of making the same
CA2427992A Expired - Lifetime CA2427992C (en) 2000-11-28 2001-11-28 Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same

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CA002427985A Expired - Lifetime CA2427985C (en) 2000-11-28 2001-11-28 Cartridges useful in cleaning dialysis solutions

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CA2699334A Expired - Lifetime CA2699334C (en) 2000-11-28 2001-11-28 Dialysis cartridges comprising sodium zirconium carbonate and zirconium basic carbonate and methods of making the same
CA2427992A Expired - Lifetime CA2427992C (en) 2000-11-28 2001-11-28 Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same

Country Status (10)

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US (3) US6627164B1 (en)
EP (2) EP1345687B1 (en)
JP (4) JP4159355B2 (en)
CN (5) CN102602992B (en)
AU (3) AU2002217930B2 (en)
CA (4) CA2427985C (en)
HK (2) HK1058782A1 (en)
MX (2) MXPA03004639A (en)
TW (1) TWI232132B (en)
WO (2) WO2002044086A2 (en)

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