CA2700607A1 - Mri-compatible head fixation frame with cooperating head coil apparatus - Google Patents

Mri-compatible head fixation frame with cooperating head coil apparatus Download PDF

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Publication number
CA2700607A1
CA2700607A1 CA2700607A CA2700607A CA2700607A1 CA 2700607 A1 CA2700607 A1 CA 2700607A1 CA 2700607 A CA2700607 A CA 2700607A CA 2700607 A CA2700607 A CA 2700607A CA 2700607 A1 CA2700607 A1 CA 2700607A1
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CA
Canada
Prior art keywords
head
head support
support frame
coil apparatus
support assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2700607A
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French (fr)
Inventor
Peter Piferi
Christopher Keidl
David Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ClearPoint Neuro Inc
Original Assignee
Surgivision, Inc.
Peter Piferi
Christopher Keidl
David Peterson
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Filing date
Publication date
Application filed by Surgivision, Inc., Peter Piferi, Christopher Keidl, David Peterson filed Critical Surgivision, Inc.
Publication of CA2700607A1 publication Critical patent/CA2700607A1/en
Abandoned legal-status Critical Current

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Abstract

A head support assembly (10) includes a base (12) configured to be removably- secured to an MRI scanner gantry, a head support frame (14) attached to the base, and a longitudinally extending head coil apparatus (30) adjustably secured to the head support frame. The head support frame includes a pair of elongated arms (18, 20) that extend outwardly in adjacent, spaced-apart, substantially co-planar relationship to form an area for receiving the head of a patient. Each arm includes a respective free end (18a, 20a), and a head engagement rod (40) is adjustably associated with each respective arm free end. The head engagement rods are configured to engage a patient's head within the head support frame. One or more additional head engagement rods may extend outwardly from the head support frame between the pair of arms.

Description

MRI-COMPATIBLE HEAD FIXATION FRAME WITH
COOPERATING HEAD COIL APPARATUS
RELATED APPLICATIONS
This application claims the benefit of and priority to U.S.
Provisional Patent Application No. 60/974,821, filed September 24, 2007, and U.S. Patent Application No. 12/134,412, filed June 6, 2008, the disclosures of s which are incorporated herein by reference as if set forth in their entireties.
FiELD OF THE INVENTION
The present invention relates generally to medical systems and apparatus and, more particularly, to MRI-interventional systems and apparatus.
BACKGROUND
Deep Brain Stimulation (DBS) is becoming an acceptable therapeutic modality in neurosurgical treatment of patients suffering from chronic pain, Parkinson's disease or seizure, and other medical conditions. Other i.s electro-stimulation therapies have also been carried out or proposed using internal stimulation of the sympathetic nerve chain and/or spinal cord, etc.
One example of a prior art DBS system is the Activa system from Medtronic, Inc. The Activa system includes an implantable pulse generator stimulator that is positioned in the chest cavity of the patient and a lead with axially spaced apart electrodes that is implanted with the electrodes disposed in neural tissue.
The lead is tunneled subsurface from the brain to the chest cavity connecting the electrodes with the pulse generator. These leads can have multiple exposed electrodes at the distal end that are connected to conductors which run along the length of the lead and connect to the pulse generator placed in the chest cavity.
?s It is believed that the clinical outcome of certain medical procedures, particularly those using DBS, may depend on the precise location of the electrodes that are in contact with tlie- tissue of interest. For example, to treat Parkinson's tremor, presently the DBS probes are placed in neural tissue with the electrodes transmitting a signal to the thalamus region of the brain. DBS
stimulation leads are conventionally implanted during a stereotactic surgery, based on pre-operative MRI and CT images. These procedures can be long in duration and may have reduced efficacy as it has been reported that, in about 30% of the patients implanted with these devices, the clinical efficacy of the device/procedure is less than optimum.
Real-time MRI-guided tools and procedures for DBS, as well as for LO other interventional medical procedures, are being developed. However, the quality of an MRI image depends on the strength of the received signal. As such radio frequency (RF) receiving coils typically are placed in close proximity to the area of a patient being imaged. These coils are often referred to as surface or head coils. One type of head coil used for imaging of the brain is a "bird cage"
Ls coil, as described in U.S. Patent No. 6,396,271. Typically, a birdcage coil has a pair of circular end rings which are bridged by a plurality of equally-spaced straight segments or legs about the periphery of a cylindrical volume. A
patient's head fits through one of the end rings and into the enclosed volume and a patient is typically unrestrained and able to move..
ao SUMMARY
In view of the above, improved head support assemblies for immobilizing the head of a patient during an MRI-guided procedure while providing access for interventional tools are provided. According to some 25 embodiments of the present invention, a head support assembly includes a base configured to be removably secured to an MRI scanner gantry, a head support frame attached to the base, and a longitudinally extending head coil apparatus adjustably secured to the head support frame. The head support frame includes a pair of elongated arms that extend upwardly in adjacent, spaced-apart, 30 relationship to form a space for receiving the head of a patient. Each arm includes a respective free end, and a head engagement rod is adjustably associated with each respective arm free end. The head engagement rods are configured to engage a patient's head within the head support frame and restrain the patient's head from movement.
2 One or more head engagement rods may extend from the head support frame between the pair of arms. These head engagement rods may be adjustably associated with the head support frame and are configured to engage a patient's head within the head support frame, and to prevent the head from s pivoting. As such, the head of a patient is secured within, and aligned with respect to, a head coil apparatus by the head engagement rods.
In some embodiments, a surface of the head support frame between the pair of arms has a substantially concave configuration, and the elongated arms have an arcuate configuration such that the head support frame 2.0 has a substantially U-shaped open-face configuration with open ends.
The head engagement rods associated with the elongated arms may extend along respective directions that are orthogonal to a longitudinal direction defined by the head support frame and head coil apparatus.
Alternatively, the head engagement rods may extend along respective directions is that are non-orthogonal to a longitudinal direction defined by the head supportframe and head coil apparatus.

In some embodiments, the head engagement rods are threadingly engaged with the head support frame. For example, each elongated arm may include a threaded passageway formed therethrough, or a threaded boss 20 associated therewith. A respective head engagement rod is threadingiy engaged with each respective aperture or threaded boss. Similarly, threaded apertures or threaded bosses may be provided at other locations on the head support frame.
A respective head engagement rod is threadingly engaged with each respective aperture or threaded boss in the head support frame.
25 The head coil apparatus includes a plurality of spaced-apart RF
coils, and is configured to surround at least a portion of a patient's head supported by the head support frame. The head coil apparatus has a substantially open-face, U-shaped configuration with spaced-apart leg portions having free ends. The head coil apparatus can be adjustably secured to the 30 head support frame between the head support frame arms such that leg portion free ends extend upwardly. Also, the head coil apparatus can be adjustable along a longitudinal direction relative to the head support frame. The open-face configuration of the head coil apparatus facilitates access to a patient by a physician/clinician, and/or interventional tools while providing sufficient signal-to-
3 noise ratio (SNR) MRI signals.
In some embodiments, the head coil apparatus includes a pair of longitudinally spaced-apart, U-shaped supports, and a plurality of spaced apart members extending longitudinally between the supports. RF coils are associated s with the spaced-apart members. In other embodiments, the head coil apparatus has a substantially unitary structure with a plurality of spaced-apart access windows formed therein. In some embodiments, the head coil apparatus has a flared or tapered end portion that further facilitates access to a patient by a physician/clinician.
In some embodiments, the head coil apparatus leg portions are movable (e.g., bendable, pivotable, etc.) to permit user adjustment of the spaced-apart relationship of the free ends. A user adjustable restraining device may also be attached to the respective leg portions to maintain a user-selected spaced-apart relationship of the free ends. In some embodiments, the restraining device is configured to contact a patient's head supported within the head support frame. In other embodiments, the restraining device does not contact a patient's head.
In some embodiments, the head coil apparatus shape and/or position is adjustable relative to the head support frame via spacers or shims positioned between the head coil apparatus and head support frame. These shims can allow a desired space to be maintained between the head support frame and the head coil apparatus.
In some embodiments, the head support frame includes a pair of head coil apparatus support rods that-extend along respective directions that can be substantially parallel with the longitudinal direction of the head coil apparatus.
The head coil apparatus is configured to be removably secured to these support rods. At least one of the head coil apparatus support rods is adjustably associated with the head support frame along the longitudinal direction such that longitudinal adjustment of the at least one coil support rod causes longitudinal adjustment of the head coil apparatus.
In some embodiments, a shield may be removably secured to the head support frame and is configured to shield non-MRI compatible objects used in conjunction with the head support assembly during an MRI-guided procedure.
For example, cables and other conductive materials and devices utilized. in a
4 medical procedure can be shielded from RF excitation via the shield. The shield can be configured to protect against liquids, such as blood, and other materials that may cause damage to cables and electronic equipment, etc.
According to other embodiments of the present invention, a head support assembly for immobilizing the head of a patient during an MRI-guided procedure includes a base configured to be removably secured to an MRI
scanner gantry, a head support frame attached to the base, and a longitudinally extending, open-face head coil apparatus secured to the base, wherein the head coil apparatus comprises a plurality of RF coils and is configured to surround at least a portion of a patient's head within the head support frame. The head coil apparatus includes opposite first and second end portions, with the first end portion positioned within the head support frame. The head coil apparatus includes a plurality of spaced-apart access windows formed therein. A
plurality of head engagement rods are adjustably associated with the head support frame, is and are configured to engage a patient's head within the head support frame.
Each rod extends through a respective access window of the head coil apparatus.
The head coil apparatus includes a plurality of spaced-apart RF
coils, and is configured to surround at least a portion of a patient's head supported by the head support frame. The head* coil apparatus has a substantially open, U-shaped open-face configuration with spaced-apart leg portions having free ends. The head coil apparatus is adjustably secured to the head support frame between the head support frame arms such that leg portion free ends extend upwardly. Also, the head coil apparatus can be adjustable along a longitudinal direction relative to the head support frame for improved alignment to intrabody (deep brain, etc.) locations of various patient head sizes.
The head support frame includes a pair of substantially co-planar arcuate members extending outwardly from the base in adjacent, spaced-apart relationship to form a substantially U-shaped head support frame. Each arcuate member comprises a free end and a respective head engagement rod associated therewith. The head engagement rods associated with the elongated-arm free ends may extend along respective directions that are orthogonal to a longitudinal direction defined by the head support frame and head coil apparatus. Alternatively, the head engagement rods can extend along respective
5 directions that are non-orthogonal to a fongitudinal direction defined by the head support frame and head coil apparatus.
In some embodiments, the head engagement rods are threadingly engaged with the head support frame. For example, each elongated arm may include a threaded aperture formed therein, or a threaded boss associated therewith, adjacent the free end. A respective head engagement rod is threadingly erigaged with each respective aperture or threaded boss.
Similarly, threaded apertures or threaded bosses may be provided at other locations on the head support frame. A respective head engagement rod is.threadingly lo engaged with each respective aperture or threaded boss in the head support frame.
Head support assemblies according to embodiments of the present invention may be particularly suitable for placing neuro-modulation leads, such as Deep Brain Stimulation ("DBS") leads, implantable parasympathetic or is sympathetic nerve chain leads and/or CNS stimulation leads, as well as other devices within the brain. Embodiments of the present invention may be suitable for a number of MRI-guided drug delivery procedures, MRI-guided ablation procedures, etc.

Head support assemblies according to embodiments of the present 20 invention can be advantageous over conventional systems because they can be easily adjustable for various patient head sizes and shapes, and can support large forces exerted in any direction without movement, thereby providing stability to the head of a patient during various interventional procedures.
In addition, head support assemblies according to embodiments of the present 25 invention do not allow a patient's head to move in any direction, including pivotal movement. Moreover, head support assemblies according to embodiments of the present invention do not interfere with other components or a physician's access to the patient. Head support assemblies, according to embodiments of the present invention can be sterilized within an autoclave, and can be wiped 30 down with disinfectant and cleaners. Head support assemblies, according to embodiments 'of the present invention can be installed and used many times without degradation, or may be single-use and disposable.
6 BRIEF DESCRIPTION-OF THE DRAWINGS
Fig. 1 is a perspective view of the head support frame of a head support assembly, according to some embodiments of the present invention.
Fig. 2 illustrates the attachment of an open-face head coil apparatus that can cooperate with a head support frame, such as that shown in Fig. 1, according to some embodiments of the present invention.
Fig. 3 is a perspective view of the open-face head coil apparatus of Fig. 2 removably and adjustably secured to the head support frame of Fig. 1, according to some embodiments of the present invention.
Fig. 4 illustrates a shield being removabiy secured to the head support frame of Fig. 1.
Fig. 5 iliustrates the head of a patient being secured to the head support assembly of Fig. 3.
Fig. 6 is an end view of the head support assembly of Fig. 5 with is the patient's head secured thereto.
Figs. 7A-7B are schematic illustrations of a patient on a gantry associated with the bore of an MRI scanner and wherein the head of the patient is secured to a head support assembly, according to some embodiments of the present invention.
Figs. 8-9 illustrate. that open-face head coil apparatus, according to embodiments of the present invention, can accommodate targeting cannulas and other interventional devices.
. Fig. 10 illustrates an open-face head coil apparatus, according to some embodiments of the present invention.
2s Figs. 11-12 are schematic iltustrations of a head support assembly wherein the legs of the open-face head coil apparatus are movable towards the head of a patient.
Figs. 13-17, illustrate various embodiments of a restraint device for altering and/or maintaining the upper end portions of the legs of an open-face head coil apparatus in a particular configuration.
Fig. 18 is a schematic illustration of a head support assembly according to embodiments of the present invention and wherein shims are utilized to adjust the position of an open-face head coil apparatus relative to a head support frame.
7 = WO 2009/042131 PCT/US2008/011043 Fig. 19 is a side perspective view of a head support assembly including an alternate design of an open-face head coil apparatus, according to other embodiments of the present invention.
Fig. 20 is a top perspective view of the head support assembly of s Fig. 19.
Figs. 21 A-21 D are various views of an open-face head coil apparatus, according to other embodiments of the present invention.
Figs. 22A-22D are various views of an open-face head coil apparatus, according to other embodiments of the present invention.
Fig. 23 is an end view of a head support assembly, according to some embodiments of the present invention, and illustrating an angled configuration of head engagement rods.
Fig. 24 is an end view of a head support frame of a head support assembly, according to other embodiments of the present invention.
Figs. 25A-25B are partial perspective.views of head support frames, according to some embodiments of the present invention, illustrating variable position head engagement rods.
Fig. 26 is a perspective view of a base for a head support frame and head coil apparatus, according to- some embodiments of the present invention.

DETAILED DESCRIPTION
The present invention now is described more fully hereinafter with reference to the accompanying drawings, in which some embodiments of the invention are shown. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
Like numbers refer to like elements throughout. In the figures, the thickness of certain lines, layers, components, elements or features may be exaggerated for clarity.
The terminology used herein is for the purpose of describing particular embodiments only and is hot intended to be limiting of the invention.
8 As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, steps, operations, s elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the specification and relevant art and should not be interpreted is in an idealized or overly formal sense unless expressly so defined herein.
Well-known functions or constructions may not be described in detail for brevity and/or clarity.
It will be understood that when an element is referred to as being "on", "attached" to, "connected" to, "coupled" with, "contacting", etc., another element, it can be directly on, attached to, connected to, coupled with or contacting the other element or intervening elements may also be present. 1n contrast, when an element is referred to as being, for example, "directly on", "directly attached" to, "directly connected" to, "directly coupled" with or "directly contacting" another element, there are no intervening elements present. It will also be appreciated by those of skill in the art that references to a structure or feature that is disposed "adjacent" another feature may have portions that overlap or underlie the adjacent feature.
Spatially relative terms, such as "under", "below", "lower", "over", "upper" and the like, may be used herein for ease of description to describe one 3 o element or feature's relationship to another element(s) or feature(s) as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is inverted, elements described as "under" or "beneath" other elements or
9 WO 2009/042131 ri,iiJS2008/011043 features would then be oriented "over" the other elements or features. Thus, the exemplary term "under" can encompass both an orientation of "over" and "under". The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted s accordingly. Similarly, the terms "upwardly", "downwardly", "vertical", "horizontal"
and the like are used herein for the purpose of explanation only unless specifically indicated otherwise.
The term "MRI compatible" means that a device is safe for use in an MRI environment and/or can operate as intended in an MRI environment, io and, as such, if residing within the high-field strength region of the magnetic field, is typically made of a non-ferromagnetic MRI compatible material(s) suitable to reside and/or operate in a high magnetic field environment.
The term "gantry" refers to a patient support of an MRI scanner and may include the patient table or other structure.
15 The term "rod" refers to an elongate member with rigidity, such as a bolt, pin, screw, etc. For example, a head engagement rod is an elongate member with sufficient structural rigidity to secure the head of a patient.
Head support assemblies according to embodiments of the present invention facilitate guiding and/or placing diagnostic or interventional devices 20 and/or therapies to any desired internal region of the brain. For example, head support assemblies according to embodiments of the present invention facilitate the placement of implantable DBS leads for brain stimulation, typically deep brain stimulation, and facilitate delivering tools or therapies that stimulate a desired region of the sympathetic nerve chain. Embodiments of the present 25 invention can be used with any MRI scanner system, including open and closed bore designs and any field strength, typically 1.0T - 10T.
Embodiments of the present invention have other uses inside or outside the brain include stem cell placement, gene therapy or drug delivery for treating physiological conditions. Some embodiments can be used to treat 30 tumors. Some embodiments can be used for diagnosing or delivering any desired therapy such as, for example, RF stimulation or ablation, laser stimulation or ablation, cryogenic stimulation or ablation, etc.
Embodiments of the present invention will now be described in detail below with reference to the figures. Referring initially to Fig. 1, a head support assembly 10 is illustrated without a head coil apparatus (Fig. 2) attached thereto. The illustrated head support assembly 10 includes a base 12 and a head support frame 14. The base 12 and head support frame 14 may be an integral unit, or may be separate components. In the illustrated embodiment, s the head support frame 14 and base 12 are an integral-unit. The base 12 is configured to be removably secured to the gantry 16 associated with an MRI
scanner. In the illustrated embodiment, the base 12 includes opposite first and second end portions 12a, 12b. A downwardly extending portion 13a, 13b of each end portion 12a, 12b is configured to engage a respective groove 16a, 16b formed within and extending along the gantry 16 in substantially parallel, spaced-apart relationship, as illustrated. The cross sectional shape of each respective downwardly extending portion 13a, 13b is configured to matingly engage a respective groove 16a, 16b. For example, the downwardly extending portions 13a, 13b may have a trapezoidal or dovetail configuration (Fig. 3). Each groove 16a, 16b has a corresponding trapezoidal or dovetail shape.
To install the illustrated base 12, downwardly extending portions 13a, 13b engage the respective grooves 16a, 16b at a free end of the gantry 16 and the base 12 and the frame 14 are moved along the gantry.16 to a selected position. One or more set screws or other locking mechanisms (not shown) may be utilized to maintain the base 12 at a selected location on the gantry 16.
Embodiments of the present invention, however, are not limited to the illustrated base 12 or to the illustrated engagement of base 12 and gantry 16.
Furthermore, it is anticipated that a base for a head support assembly of the present invention can be customized to fit and be secured to any type of gantry.
That is, the base may be a universal base usable with several different MRI
scanners from different manufacturers, or may be MRI scanner type specific, The illustrated head support frame 14 includes a pair of elongated arms 18, 20 that extend outwardly from the base 12 in adjacent, spaced-apart relationship to form a space for receiving the head of a patient. The illustrated 3 o arms 18, 20 lie in substantially the same plane (i.e., are substantially co-planar) and have an arcuate configuration. The surface 14a of the head support frame 14 between the pair of arms 18, 20 has a concave configuration. As such, the concave surface 14a and arcuate arms 18, 20 give the head support frame 14 a substantially U-shaped configuration. In the illustrated embodiment, a bracing member 19. is attached to each respective arcuate arm 18, 20 to provide rigidity and stability. However, head support frames according to embodiments of the present invention do not require bracing members. Moreover, head support frames according to embodiments of the present invention may have various s structural configurations, without limitation.
The illustrated head support assembly 10 includes a longitudinally extending head coil apparatus 30 (Fig. 2) secured to the head support frame 14.
The head coil apparatus 30 has an open-face, substantially U-shaped configuration with spaced-apart leg portions 30a, 30b having free ends. The lo head coil apparatus 30 is secured to the head support frame 14 between the head support frame arms 18, 20 such that the free ends of the leg portions 30a, 30b extend upwardly, as illustrated. Also, the head coil apparatus 30 can be adjustable along a longitudinal direction L (Fig. 1) relative to the head support frame 14, as will be described below.
is The illustrated open-face head coil apparatus 30 includes a pair of longitudinally spaced-apart, U-shaped supports 32, 34 and a plurality of spaced apart connecting members 36 that extend longitudinally between the supports 32, 34. RF coils are contained within at least some of the connecting members 36, along with the circuitry for controlling RF excitation of the RF coils. An 20 exemplary supplier of RF coils that may be utilized is Midwest RF, LLC., Hartland, WI. The head coil apparatus 30 is configured to surround at least a portion of a patient's head supported by the head support frame 14. As such, RF
coils can be positioned as desired relative to a patient's head. Embodiments of the present invention are not limited to the configuration of the illustrated open-25 face head coil apparatus 30 of Fig. 2. Head coil apparatus 30 may have various shapes and configurations, but includes an open-face configuration.
In some embodiments, the head coil apparatus 30 can include two pair of spaced apart shoulders 38 that extend outwardly from respective, opposing connecting members 36, as illustrated in Figs. 2-3. The shoulders 38 3o are configured to support the head coil apparatus 30 on the frame 14 and to allow the head coil apparatus 30 to be adjustable along a longitudinal direction L
(Fig. 1) relative to the head support frame 14. Each shoulder 38 includes a lower surface 38a with a longitudinally extending groove 39 formed therein that is configured to rest upon a longitudinally extending support rod associated with the head support frame 14. At least one of the support rods may be threaded so as to threadingly engage a respective threaded passageway formed within the head support frame 14.
In the illustrated embodiment, a threaded passageway 23 is formed s through arcuate arm 18 and extends along a direction that is substantially parallel with the longitudinal direction L (although it need not be). Threaded head coil apparatus support rod 22 extends outwardly from both ends of the passageway 23 such that a pair of shoulders 38 on one side of the head coil apparatus 30 rests on the support rod 22. A passageway 25 is formed through arcuate arm 20 and extends along a direction that is substantially parallel with the longitudinal direction L (although it need not be). A head coil apparatus support rod 24 extends outwardly from both ends of the passageway 25 such that the other pair of shoulders 38 on the opposite side of the head coil apparatus 30 rests on the support rod 24.
Threaded support rod 22 includes an enlarged head portion 22a (Fig. 3) at one end thereof that facilitates rotation of the support rod 22 by a clinician. The enlarged head portion 22a may have a knurled circumference to facilitate gripping and rotation by a user, as would be understood by those skilled in the art. The head coil apparatus 30 is supported on threaded support rod 22 such that shoulder 38 abuts the head portion 22a. As such, clockwise rotation of the support rod 22 causes the head coil apparatus 30 to be moved one way along the longitudinal. direction L. Counterclockwise rotation of the threaded support rod 22 will create a space between shoulder 38 and the enlarged head portion 22a, allowing the head coil apparatus to be moved by a clinician in the opposite way along the longitudinal direction L.
Embodiments of the present invention are not limited to the illustrated shoulders 38 and support rods 22, 24. Other ways of adjustably supporting'the head coil apparatus 30 on the head support frame 14 may be utilized, without limitation.
3 0' Each arm 18, 20 of the head support frame 14 includes a respective free end 18a, 20a (Fig. 1). A head engagement rod 40 is adjustably associated near each respective arm free end 18a, 20a. The head engagement rods 40 are configured to engage a patient's head within the head support frame 14.

In the illustrated embodiment of Fig. 3, a threaded passageway 42 extends through each arcuate arm 18, 20 adjacent each respective free end 18a, 20a, as illustrated. A head engagement rod 40 is threaded and is configured to threadingly engage a respective threaded passageway 42. In the illustrated s embodiment, each head engagement rod 40 includes opposite first and second end portions 40a, 40b. The first end portion 40a of each head engagement rod has a conical shape that is configured to engage the skull of a patient's head and make sufficient contact with the skull to maintain the patient's head in a desired orientation. The second end portion 40b of each head engagement rod 40 has lo an enlarged configuration that facilitates rotation of the head engagement rod 40 by a clinician. The enlarged second end portion 40b may have a knurled circumference to facilitate gripping and rotation by a clinician, as would be understood by those skilled in the art. Head engagement rods may be formed from various m'aterials (e.g., titanium, etc.) and may be disposable.
Alternatively, is the first end portion 40a of each head engagement rod 40 may be removable (and disposable) from the remainder of the head engagement rod 40. The first end portion 40a of each head engagement rod 40 may be formed from various materials (e.g., titanium, etc.).
The threaded passageway 42 formed in each of the arcuate arms 20 18, 20 may extend- along respective directions that are orthogonal to the longitudinal direction L (Fig. 1). Alternatively, the threaded passageway 42 formed in each of the arcuate arms 18, 20 may extend along a direction that is non-orthogonal to the longitudinal direction L. As such, head engagement rods 40 associated with the elongated arm free ends 18a, 20a may extend along 25 respective directions that are orthogonal to the longitudinal direction L, or may extend along respective directions that are non-orthogonal to the longitudinal direction L. For example, in some embodiments, head engagement rods 40 may be angled downwardly, upwardly, forwardly, or rearwardly relative to the head support frame 14.
30 In the illustrated embodiment, a pair of additional head engagement rods 44 extend outwardly from the head support frame surface 14a between the pair of arms 18, 20. These additional head engagement rods 44 are adjustably associated with the head support frame 14 and are configured to engage and support a patient's head within the head support frame. The illustrated head engagement rods 44 have a conically-shaped end portion 44a that is configured to engage the skull of a patient's head and make sufficient contact with the skull to maintain the patient's head in a desired orientation. One or more of the head engagement rods 40, 44 may be particularly effective in preventing a patient's head from pivoting during fixation within the head support frame 14. As such, the head of a patient is secured within the head support frame 14 by the head engagement rods 40 associated with the head support frame arms 18, 20 and by head engagement rods 44 associated with the head support frame 14 between the arms 18, 20.
In some embodiments, the head engagement rods 44 are threadingly engaged with the head support frame 14. For example, in the illustrated embodiment, a pair of threaded bosses 46 extend from the portion of the head support frame 14 between the arcuate arms 18, 20. A respective head engagement rod 44 is threadingly engaged with each respective threaded boss 46.
The threaded bosses 46 may each have an axial direction that is orthogonal to the longitudinal direction L. Alternatively, the threaded bosses may each have an axial direction that is non-orthogonal to the longitudinal direction L. As such, head engagement rods 44 associated may extend along respective directions that are orthogonal to the longitudinal direction L, or may extend along respective directions that are non-orthogonal to the longitudinal direction L. For example, in some embodiments, head engagement rods 44 may be angled forwardly or rearwardly relative to the head support frame 14.
Referring to Fig. 24, in some embodiments, a head support frame 14 can include a top portion 15 secured to arms 18, 20. The illustrated top portion 15 includes corresponding arms 18', 20' having an arcuate configuration that overlie the forehead of a patient. Thus, the illustrated head support frame of Fig. 24 completely surrounds the head H of a patient. A pair head engagement rods 40 are adjustably associated with the top port ion 15 and are configured to 3 o engage a patient's head, as illustrated.
Referring now to Fig. 4, the head support assembly 10 may also include a cover or shield 50 that is configured to cover electrical components, cables, and the like. In some embodiments, the shield 50 is configured to shield non-MRI compatible objects used in conjunction with the head support assembly ,10 during an MRI-guided procedure. For example, cables and other conductive materials and devices utilized in a medical procedure can be shielded from RF
excitation via the shield 50. The shield may be removably secured to the head support frame to facilitate access to cables and other devices used for various s MRI guided procedures. In some embodiments, the shield 50 may be configured to protect against foreign material, including liquids, etc.
All of the components of the head support assembly 10 described above (i.e., the base 12, the head support frame 14, the head engagement rods 40, 44, the open-face head coil apparatus 30, and the shield 50) are formed from io or include MRI-compatible material. Exemplary MRI-compatible materials include, but are not limited to, various polymeric materials (e.g., plastics), carbon fiber materials, glass-filled epoxies, and metals such as nickel-titanium alloys (e.g., Nitinol). As known to those skilled in the art of MRI, Nitinol is non-ferromagnetic with a lower magnetic susceptibility than conventional stainless 15 steel..
Figs. 7A-7B are schematic illustrations of a patient on a gantry associated with the bore of an MRI scanner and wherein the head of the patient is secured to a head support assembly 10, according to some embodiments of the present invention. The illustrated head support assembly 10 includes a 20 neurosurgical head support frame 14' secured to the gantry 16 of an MRI
scanner 60. An open-face head coil apparatus 30 is adjustably secured to the head support frame 14' and is positioned around the head of a patient secured to the head support frame 14'. The head coil apparatus 30 has an open-face U-shaped configuration as described above with respect to Figs. 2-6.
25 Figs. 8-10 illustrate open-face head coil apparatus according to various embodiments of the present invention. In Fig. 8, an open-face head coil apparatus 30' includes opposite first and second end portions 31 a, 31 b. The head coil apparatus first end portion 31a is positioned within the head support frame 14'. The head coil apparatus second end portion 31 b is secured to the 30 gantry 16 of an MRI scanner. In other embodiments, head coil apparatus second end portion 31b can be secured to a movable base configured to allow adjustment of the position of the head coil apparatus 30. The illustrated head coil apparatus 30' includes spaced-apart, upwardly extending members 36' with open side windows and having an inverted, substantially U shape. RF coils, and associated circuitry for the RF coils are'contained within the upwardly extending members 36' and/or second end portion 31b. In some embodiments, the illustrated head coil apparatus 30' includes an intermediate portion 31c between the first and second end portions 31a, 31b. Intermediate portion 31c may contain s additional RF coils and associated circuitry. RF coils located in intermediate portion 31c can be positioned proximate to a targeting frame and/or other interventional device. In some embodiments, electronic components, cables, and circuitry for the head coil apparatus 30' can be stored within intermediate portion 31 c.
In Fig. 9, an open-face head coil apparatus 30", similar to the head coil apparatus 30 of Figs. 2-6, is positioned within a head support frame 14' and secured to the gantry 16 of an MRI scanner. A secondary RF coil 37 is provided and is positioned adjacent to a targeting frame 100 that is secured to the head of a patient. The secondary coil 37 can obtain local MRI signals and facilitates is identifying the location of the targeting frame 100 during an MRI-guided procedure. _ In Fig. 10, an open-face head coil apparatus 30"', similar to the head coil apparatus 30 of Figs. 2-6, is positioned within a head support frame 14' and secured to the gantry 16 of an MRI scanner. The leg portions 30a, 30b of the head coil apparatus 30"' have an arcuate configuration such that each partially overlies the head of a patient.
In some embodiments of the present invention, the leg portions of an open-face head coil apparatus are movable (e.g., bendable, deformable, pivotable, etc.) to permit user adjustment of the spaced-apart relationship of the leg portions 30a, 30b. For example, the leg portions 30a, 30b of head coil apparatus 30 may be configured to pivot relative to each other, as illustrated in Fig. 11. The leg portions 30a, 30b of head coil apparatus 30 may be configured to bend relative to each other, as illustrated in Fig. 12.
Referring now to Figs. 13-17, a user adjustable restraining device 3 o 80 may also be attached to the respective leg portions 30a, 30b of a head co.il apparatus 30 to obtain and/or maintain a user-selected spaced-apart relationship of the leg portions 30a, 30b. In some embodiments, the restraining device 80 is configured to contact a patient's head supported within the head support frame (Fig. 13). In other embodiments, the restraining device does not contact a patient's head. Various types of restrairiirTg devices may be utilized, without limitation. An exemplary restraining device is a flexible strap 80' configured to adjustably position leg portions 30a, 30b relative to each other, as illustrated in Fig. 15. The illustrated flexible strap 80' has one end secured to leg portion 30b.
The opposite end of the flexible strap 80' includes a plurality of spaced apart notches 82 that are configured to engage with member 84 associated with leg portion 30a to maintain the flexible strap 80' at a length selected to maintain the leg portions 30a, 30b a desired distance from each other.
Another exemplary restraining device is a threaded member 80"
configured to adjustably position leg portions 30a, 30b relative to each other, as illustrated in Fig. 16. The illustrated threaded member 80" has one end secured to leg portion 30b. The opposite end of the threaded member 80" is configured to threadingly engage a threaded rod 86 that is associated with leg portion 30a.
Rotation of threaded rod 86 and threaded member 80" relative to each other is configured to move leg portions 30a, 30b *relative to each other and to maintain the leg portions 30a, 30b a desired distance from each other, as would be understood by those skilled in the art.
Another exemplary restraining device 80"' configured to adjustably position leg portions 30a, 30b relative to each other is illustrated in Fig.
17. The illustrated device 80"' includes an elongated member 88 having one end secured to leg portion 30b. The opposite end of the elongated rriember 88 is configured to be slidably received within a clamping device 89 associated with leg portion 30a. As the elongated member is pulled through the clamping device, the leg portions 30a, 30b are forced closer toward each other. Clamping device aS 89 is configured to maintain the leg portions 30a, 30b a desired distance from each other, as would be understood by those skilled in the art.
Referring now to Fig. 18, an open-face head coil apparatus 30 may be adjustable in elevation relative to a head support frame 14 via spacers or shims 90 positioned between the head coil apparatus 30 and head support frame 14. These shims 90 allow a desired space to be maintained between the head support frame 14 and the head coil apparatus 30 and may allow a more customizable patient-specific fit of the open-face head coil apparatus.
Referring now to Figs. 19-20, a head support assembly 110 for immobilizing the head of a patient during an MRI-guided procedure, according to other embodiments of the present invention, is illustrated. The illustrated head support assembly 110 includes a base 12 that is configured to be removably secured to an MRI scanner gantry 16. A head support frame 14 is attached to the base 12. A longitudinally extending, open-face head coil apparatus 130 is also secured to the base, and is configured to surround at least a portion of a patient's head secured to the head support frame 14. The head coil apparatus 130 includes opposite first and second end portions 130a, 130b, with the first end portion 130a positioned within the head support frame 14. The head coil apparatus 130 includes a plurality of spaced-apart access windows 133 formed io therein and a.plurality of internal RF coils. The head coil apparatus 130 can include various numbers of RF coils, and the RF coils can be positioned in various locations. For example, there may be two (2) RF coils, three (3) RF
coils, five (5) RF coils, eight (8) RF coils, etc. In some embodiments, the head coil apparatus 130 includes twelve (12) RF coils, and may be multi-channel, e.g., a.s eight (8) channels.
The head coil apparatus 130 includes a pair of flanges (one illustrated) 131 that are used to secure the head coil apparatus to a movable portion 12' of the base 12. Threaded fasteners 132 (e.g., bolts, screws, etc.) are utilized to secure the flanges 131, and thias the head coil apparatus 130, to the 20 base 12 as would be understood by those skilled in the art. The movable portion 12' of the base 12 is configured to move forward and backward along longitudinal direction L. Actuator 134 is configured to cause movement along the longitudinal direction L in response to rotation thereof by a user. For example, clockwise rotation of actuator 134 can cause movement of the head coil 2s apparatus 130 along direction L (e.g., forward or backward movement), and counterclockwise rotation of actuator 134 can cause movement of the head coil apparatus 130 along direction L (e.g., forward or backward movement).
A plurality of head engagement rods 40, 44 are adjustably associated with the head support frame 14, as described above, and are 30 configured to engage and support a patient's head within the head support frame 14: Each rod 40, 44 extends through a respective access window 133 of the head coil apparatus 130. The head coil apparatus second end portion 130b is configured to shield electronics, cables, etc. associated with the head coil apparatus 30 and extends in a direction away from the patient's head and torso.

A patient tie-down strap 135 is also illustrated in Fig. 19. This strap 135 is configured to extend over the head of a patient and over the head coil apparatus 130, and can be used to help secure the head of a patient and/or the head coil apparatus 130 and prevent movement thereof. A slot 136 in the MRI
s gantry 16 is also illustrated and may be utilized to receive straps for securing the head coil apparatus 130 to the MRI gantry 16, as will be described below.
Figs. 21A-21D and 22A-22D are various views of open-face head coil apparatus 130', 130", according to other embodiments of the present invention. Each of the illustrated head coil apparatus 130', 130" is similar in io structure to the head coil apparatus 130 of Figs. 19-20, and each head coil apparatus 130', 130" is configured to be positioned within a head support frame, as described above However, head coil apparatus 130', 130" each have a respective tapered or flared end portion 130a, as illustrated. The tapered or flared end portion 130a facilitates access to a patient by a physician/clinician.
is Fig. 23 is an end view of a head support assembly 10, according to some embodiments of the present invention, and illustrating that head engagement rods 40 may have an angled configuration. For example, the head engagement rods 40 may have an angle a relative to horizontal between about two degrees and thirty degrees (2 - 30 ), and more particularly between about 20 five degrees and fifteen degrees (5 - 150).
Each of the illustrated head coil apparatus 30, 30', 30", 30"', 130 have an open-face and open end configuration. For example, as illustrated in Fig. 10, the head coil apparatus 30"' does not have a member extending between the two leg portions 30a, 30b or across the end portions. As such, the 25 open-face and open end configuration of each of the illustrated head coil apparatus embodiments allows one or more targeting cannula and other interventional devices to project out of the head of a patient and into the bore of an MRI scanner magnet without being restricted. In other words head coil apparatus according to embodiments of the preserit invention do not interfere 3 o with interventional devices in the way that conventional head coil apparatus do.
Referring to Figs. 25A-25B, head support frames, according to some embodiments of the present invention, can have variable position head engagement rods 40. For example, in Fig. 25A, a head engagement rod 40 is movably secured to an arm 18 of a head support frame 14 via a collar 41. The illustrated collar 41 cooperates with the-arm and is slidable along the arm as indicated by arrow A (e.g., up and down) relative to the arm free end 18a.
Thus the head engagement rod 40 is movable proximally and distally relative to (e.g., toward and away from) the free end 18a of the arm 18. A head engagement rod 40 is threadably associated with the collar 41 and is utilized to engage the head of a patient as described above. Collar 41 can include a locking device (not illustrated), such as a set screw or bolt, for securing the collar 41 in a particular position on the arm 18. By sliding relative to the arm 18, collar 41 allows the head engagement rod to have variable positions, thereby facilitating engagement lo with different size heads of patients. Both head engagement rods 40 associated with a head support frame 14 can be slidable relative to a respective arm as illustrated in Fig. 25A.
In Fig. 25B, a head engagement rod 40 is movably secured to an arm 18 of a head support frame 14 via a collar 41. The illustrated collar 41 ls cooperates with the arm and is slidable along the arm as indicated by arrow A
(e.g., up and down) relative to the arm free end 18a. Thus the head engagement rod 40 is movable proximally and distally relative to (e.g., toward and away from) the free end 18a of the arm 18. A head engagemeht rod 40 is threadably associated with the collar and is utilized to engage the head of a patient as 20 described above. The arm 18 includes a slot 43 formed therethrough, as illustrated. The head engagement rod 40 extends through the slot 43 as illustrated. Collar 41 can include a locking device (not illustrated), such as a set screw or bolt, for securing the collar 41 in a particular position on the arm 18. By sliding relative to the arm 18, collar 41 allows the head engagement rod to have 25 variable positions, thereby facilitating engagement with different size heads of patients.
Fig. 26 is a perspective view of a base 12 for a head support frame and head coil apparatus, according to some embodiments of the present invention. MRI scanner manufacturers use different table/gantry configurations 30 and there are different table/gantry configurations for different models by the.
same MRI scanner manufacturer. The illustrated base 12 is configured to have a head support frame 14 and head coil apparatus 130 secured thereto. The base 12 is intended to be a "universal" base that is configured to be secured to different table/gantry configurations. In addition to the head support frame and head coil apparatus 130, the base 12 also includes a pair of camera holders 200 for receiving MRI-compatible cameras therein. The illustrated base 12 includes a pair of clamping screws 202 in spaced-apart relationship. Clamping screws 202 are configured to lock the rear of the base 12 to an MRI scanner table/gantry. The illustrated base also includes one or more adjustable clips that are configured to fasten the front of the base 12 to an MRI scanner table/gantry. For example, the clips 204 may be configured to engage slots 136 illustrated in Fig. 19. The illustrated clips 204 extend outwardly from the base 12.
Adjustable straps may also be utilized in lieu of or in conjunction with the clips 204. The clips 204 may have various adjustments to facilitate securing the base to_the table/gantry of different MRI scanners. The clips 204 and clamping screws 202 can individually or collectively be referred to as adjustable fasteners that facilitate securing the base 12 to, different types of gantries (e.g., gantries of different MRI scanner models, different manufacturers, etc.).
1s The illustrated base 12 also includes an actuator 134 for adjusting the head coil apparatus relative to the head support frame 14 and/or the head of a patient. One of the bolts 208 securing the head support frame 14 to the base 12 is also illustrated.
The foregoing is illustrative of the present invention and is not to be construed as limiting thereof. Although a few exemplary embodiments of this invention have been described, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the teachings and advantages of this invention.
Accordingly, all such modifications are intended to be included within the scope of this invention as defined in the claims..The invention is defined by the following claims, with equivalents of the claims to be included therein.

Claims (28)

THAT WHICH IS CLAIMED IS:
1. A head support assembly for immobilizing the head of a patient during an MRI-guided procedure, comprising:
a base configured to be removably secured to a gantry;
a head support frame attached to the base, comprising a pair of elongated arms extending outwardly in adjacent, spaced-apart relationship, wherein each arm comprises a free end;
a pair of head engagement rods, wherein each rod is adjustably associated with a respective arm, and wherein the rods are configured to engage a patient's head within the head support frame;
a pair of head coil support rods, each head coil support rod associated with a respective arm; and an elongated head coil apparatus adjustably supported by the head coil support rods and configured to surround at least a portion of a patient's head, wherein the head coil apparatus defines a longitudinal directions and comprises a plurality of spaced-apart RF coils.
2. The head support assembly of Claim 1, wherein each head engagement rod is located adjacent the free end of a respective arm.
3. The head support assembly of Claim 1, wherein the elongated arms have an arcuate configuration such that the head support frame has a substantially U-shaped configuration.
4. The head support assembly of Claim 1, wherein each head engagement rod extends along a respective different direction relative to the head support frame.
5. The head support assembly of Claim 1, wherein each head engagement rod extends along a respective direction that has an angle of between about five degrees and fifteen degrees (5° - 15°) relative to horizontal.
6. The head support assembly of Claim 1, wherein at least one of the head engagement rods is movable proximally and distally relative to the free end of a respective arm.
7. The head support assembly of Claim 1, further comprising at least one head engagement rod extending outwardly from the head support frame between the pair of arms, wherein the at least one head engagement rod is adjustably associated with the head support frame and configured to engage a patient's head within the head support frame.
8. The head support assembly of Claim 7, wherein the at least one head engagement rod is threadingly engaged with the head support frame.
9. The head support assembly of Claim 1, wherein the head coil apparatus has an open-face, substantially U-shaped configuration with spaced-apart leg portions having free ends, wherein the head coil apparatus is adjustably secured to the head support frame between the head support frame arms such that the leg portion free ends extend upwardly.
10. The head support assembly of Claim 9, wherein the leg portions are movable to permit user adjustment of the spaced-apart relationship of the free ends.
11. The head support assembly of Claim 10, further comprising a user adjustable restraining device attached to the respective leg portions that is configured to obtain and/or maintain a user-selected spaced-apart relationship of the free ends.
12. The head support assembly of Claim 11, wherein the restraining device is configured to contact a patient's head supported within the head support frame.
13. The head support assembly of Claim 1, wherein the head coil apparatus is adjustable along a longitudinal direction relative to the head support frame.
14. The head support assembly of Claim 1, wherein the head coil apparatus is adjustable relative to the head support frame via shims positioned between the head coil and head support frame.
15. The head support assembly of Claim 1, wherein at least one of the head coil apparatus support rods is adjustably associated with the head support frame along the longitudinal direction, and wherein longitudinal adjustment of the at least one head coil apparatus support rod causes longitudinal adjustment of the head coil apparatus.
16. The head support assembly of Claim 1, further comprising a shield removably secured to the base, wherein the shield comprises MRI
compatible material and is configured to shield non-MRI compatible objects used in conjunction with the head support assembly during an MRI-guided procedure.
17. The head support assembly of Claim 1, wherein the head coil apparatus comprises a pair of longitudinally spaced-apart, U-shaped supports, and a plurality of spaced apart connecting members extending longitudinally between the supports, wherein RF coils are contained within at least some of the connecting members, along with the circuitry for controlling RF
excitation of the RF coils.
18. A head support assembly for immobilizing the head of a patient during an MRI-guided procedure, comprising:
a base configured to be removably secured to a gantry;
a head support frame attached to the base;
an elongated head coil apparatus secured to the base, wherein the head coil apparatus defines a longitudinal direction and comprises a plurality of RF coils and is configured to surround at least a portion of a patient's head within the head support frame, wherein the head coil apparatus includes opposite first and second end portions, and wherein the head coil apparatus comprises a plurality of spaced-apart access windows formed therein; and a plurality of head engagement rods adjustably associated with the head support frame, wherein the rods are configured to engage a patient's head within the head support frame, and wherein each rod extends through a respective access window of the head coil apparatus.
19. The head support assembly of Claim 18, wherein the head coil apparatus has an open-face, substantially U-shaped configuration with spaced-apart leg portions having free ends that extend upwardly.
20. The head support assembly of Claim 18, wherein the head support frame comprises a pair of arcuate members extending outwardly from the base in adjacent, spaced-apart relationship to form a substantially U-shaped head support frame.
21. The head support assembly of Claim 20, wherein the arcuate arms are substantially co-planar.
22. The head support assembly of Claim 18, wherein each head engagement rod extends along a respective different direction relative to a longitudinal direction defined by the head support frame.
23. The head support assembly of Claim 18, wherein the head coil first end portion is positioned within the head support frame.
24. The head support assembly of Claim 18, wherein the head support frame is configured to substantially surround the head of a patient.
25. The head support assembly of Claim 18, further comprising a head support frame top portion secured to the head support frame, and wherein the top portion includes at least one head engagement rod adjustably associated therewith, wherein the at least one rod is configured to engage a patient's head within the head support frame.
26. The head support assembly of Claim 18, wherein the head support frame comprises a pair of elongated arms extending outwardly in adjacent, spaced-apart relationship, wherein each arm comprises a free end, and wherein at least one of the head engagement rods is movable proximally and distally relative to the free end of a respective arm.
27. The head support assembly of Claim 18, wherein the base includes adjustable fasteners that facilitate securing the base to different gantries.
28. A head support assembly for immobilizing the head of a patient during an MRI-guided procedure, comprising:
a base, wherein the base includes adjustable fasteners that facilitate removably securing the base to a gantry;
a head support frame attached to the base, an elongated head coil apparatus secured to the base, wherein the head coil apparatus defines a longitudinal direction and comprises a plurality of RF coils and is configured to surround at least a portion of a patient's head within the head support frame, wherein the head coil apparatus includes opposite first and second end portions, and wherein the head coil apparatus comprises a plurality of spaced-apart access windows formed therein;
a plurality of head engagement rods adjustably associated with the head support frame, wherein the rods are configured to engage a patient's head within the head support frame, and wherein each rod extends through a respective access window of the head coil apparatus; and at least one camera holder attached to the base, wherein the camera holder is configured to receive an MRI-compatible camera therewithin.
CA2700607A 2007-09-24 2008-09-24 Mri-compatible head fixation frame with cooperating head coil apparatus Abandoned CA2700607A1 (en)

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US97482107P 2007-09-24 2007-09-24
US60/974,821 2007-09-24
US12/134,412 2008-06-06
US12/134,412 US8175677B2 (en) 2007-06-07 2008-06-06 MRI-guided medical interventional systems and methods
PCT/US2008/011043 WO2009042131A1 (en) 2007-09-24 2008-09-24 Mri-compatible head fixation frame with cooperating head coil apparatus

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CA2700607A Abandoned CA2700607A1 (en) 2007-09-24 2008-09-24 Mri-compatible head fixation frame with cooperating head coil apparatus
CA2700577A Abandoned CA2700577A1 (en) 2007-09-24 2008-09-24 Mri surgical systems for real-time visualizations using mri image data and predefined data of surgical tools
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8979871B2 (en) 2009-08-13 2015-03-17 Monteris Medical Corporation Image-guided therapy of a tissue
US9333038B2 (en) 2000-06-15 2016-05-10 Monteris Medical Corporation Hyperthermia treatment and probe therefore
US9433383B2 (en) 2014-03-18 2016-09-06 Monteris Medical Corporation Image-guided therapy of a tissue
US9504484B2 (en) 2014-03-18 2016-11-29 Monteris Medical Corporation Image-guided therapy of a tissue
US10327830B2 (en) 2015-04-01 2019-06-25 Monteris Medical Corporation Cryotherapy, thermal therapy, temperature modulation therapy, and probe apparatus therefor
US10675113B2 (en) 2014-03-18 2020-06-09 Monteris Medical Corporation Automated therapy of a three-dimensional tissue region
US11298043B2 (en) 2016-08-30 2022-04-12 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
US11497576B2 (en) 2017-07-17 2022-11-15 Voyager Therapeutics, Inc. Trajectory array guide system

Families Citing this family (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040162637A1 (en) 2002-07-25 2004-08-19 Yulun Wang Medical tele-robotic system with a master remote station with an arbitrator
US7813836B2 (en) 2003-12-09 2010-10-12 Intouch Technologies, Inc. Protocol for a remotely controlled videoconferencing robot
US8077963B2 (en) 2004-07-13 2011-12-13 Yulun Wang Mobile robot with a head-based movement mapping scheme
US9198728B2 (en) 2005-09-30 2015-12-01 Intouch Technologies, Inc. Multi-camera mobile teleconferencing platform
US8849679B2 (en) 2006-06-15 2014-09-30 Intouch Technologies, Inc. Remote controlled robot system that provides medical images
US9160783B2 (en) 2007-05-09 2015-10-13 Intouch Technologies, Inc. Robot system that operates through a network firewall
US8175677B2 (en) 2007-06-07 2012-05-08 MRI Interventions, Inc. MRI-guided medical interventional systems and methods
KR20100037597A (en) * 2007-07-02 2010-04-09 보르그워너 인코퍼레이티드 Inlet design for a pump assembly
EP2192871B8 (en) 2007-09-24 2015-01-28 MRI Interventions, Inc. Mri-compatible patch and method for identifying a position
US8315689B2 (en) 2007-09-24 2012-11-20 MRI Interventions, Inc. MRI surgical systems for real-time visualizations using MRI image data and predefined data of surgical tools
EP2194906B8 (en) 2007-09-24 2015-04-22 Mri Interventions, Inc. Mri-guided medical interventional system
WO2009067205A1 (en) * 2007-11-21 2009-05-28 Surgi-Vision, Inc. Methods, systems and computer program products for positioning a guidance apparatus relative to a patient
US10875182B2 (en) 2008-03-20 2020-12-29 Teladoc Health, Inc. Remote presence system mounted to operating room hardware
US8179418B2 (en) 2008-04-14 2012-05-15 Intouch Technologies, Inc. Robotic based health care system
US8170241B2 (en) 2008-04-17 2012-05-01 Intouch Technologies, Inc. Mobile tele-presence system with a microphone system
US9193065B2 (en) 2008-07-10 2015-11-24 Intouch Technologies, Inc. Docking system for a tele-presence robot
US9842192B2 (en) 2008-07-11 2017-12-12 Intouch Technologies, Inc. Tele-presence robot system with multi-cast features
US8728092B2 (en) 2008-08-14 2014-05-20 Monteris Medical Corporation Stereotactic drive system
US8747418B2 (en) 2008-08-15 2014-06-10 Monteris Medical Corporation Trajectory guide
US20100063422A1 (en) * 2008-09-08 2010-03-11 Sunnybrook Health Sciences Center Ultrasound therapy transducer head and ultrasound therapy system incorporating the same
US8320990B2 (en) * 2008-09-12 2012-11-27 MRI Interventions, Inc. Intrabody MRI stacked flat loop antennas and related systems
US8340819B2 (en) 2008-09-18 2012-12-25 Intouch Technologies, Inc. Mobile videoconferencing robot system with network adaptive driving
US8270698B2 (en) * 2008-09-24 2012-09-18 Merge Healthcare Incorporated Anterior commissure and posterior commissure segmentation system and method
US8996165B2 (en) 2008-10-21 2015-03-31 Intouch Technologies, Inc. Telepresence robot with a camera boom
US8463435B2 (en) 2008-11-25 2013-06-11 Intouch Technologies, Inc. Server connectivity control for tele-presence robot
US9138891B2 (en) 2008-11-25 2015-09-22 Intouch Technologies, Inc. Server connectivity control for tele-presence robot
US20100198052A1 (en) * 2009-01-28 2010-08-05 Kimble Jenkins Mri-compatible articulating arms and related systems and methods
US8849680B2 (en) 2009-01-29 2014-09-30 Intouch Technologies, Inc. Documentation through a remote presence robot
US20100217115A1 (en) * 2009-02-25 2010-08-26 Hushek Stephen G Temperature sensing within a patient during mr imaging
CN201384493Y (en) * 2009-03-12 2010-01-20 西门子迈迪特(深圳)磁共振有限公司 Positioning device used for magnetic resonance system
WO2010110881A1 (en) * 2009-03-27 2010-09-30 Hetherington Hoby P Improved transceiver apparatus, system, and methodology for superior in-vivo imaging of human anatomy
US9232977B1 (en) * 2009-03-27 2016-01-12 Tausif-Ur Rehman Instrument guiding device
US8897920B2 (en) 2009-04-17 2014-11-25 Intouch Technologies, Inc. Tele-presence robot system with software modularity, projector and laser pointer
GB0908784D0 (en) * 2009-05-21 2009-07-01 Renishaw Plc Apparatus for imaging a body part
GB0908787D0 (en) 2009-05-21 2009-07-01 Renishaw Plc Head clamp for imaging and neurosurgery
EP2440130A4 (en) 2009-06-08 2015-06-03 Mri Interventions Inc Mri-guided surgical systems with proximity alerts
US8396532B2 (en) 2009-06-16 2013-03-12 MRI Interventions, Inc. MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time
WO2010148095A2 (en) * 2009-06-16 2010-12-23 Neocoil, Llc Modular apparatus for magnetic resonance imaging
DE102009034312A1 (en) * 2009-07-23 2011-01-27 Martin Hempel Protective housing for flexible MR coils
ES2524480T3 (en) * 2009-07-29 2014-12-09 Mauna Kea Technologies Apparatus for microscopy of bundles of brain fibers
US11399153B2 (en) 2009-08-26 2022-07-26 Teladoc Health, Inc. Portable telepresence apparatus
US8384755B2 (en) 2009-08-26 2013-02-26 Intouch Technologies, Inc. Portable remote presence robot
US9844414B2 (en) * 2009-08-31 2017-12-19 Gregory S. Fischer System and method for robotic surgical intervention in a magnetic resonance imager
JP2013508103A (en) * 2009-10-28 2013-03-07 イムリス インク． Automatic registration of images for image guided surgery
US9864032B2 (en) * 2010-01-05 2018-01-09 National Health Research Institutes Magnetic resonance imaging system
US20110187875A1 (en) * 2010-02-04 2011-08-04 Intouch Technologies, Inc. Robot face used in a sterile environment
US11154981B2 (en) 2010-02-04 2021-10-26 Teladoc Health, Inc. Robot user interface for telepresence robot system
US8670017B2 (en) 2010-03-04 2014-03-11 Intouch Technologies, Inc. Remote presence system including a cart that supports a robot face and an overhead camera
WO2011128800A1 (en) * 2010-04-14 2011-10-20 Koninklijke Philips Electronics N.V. Instrument guiding during magnetic resonance imaging
US10105485B2 (en) 2010-04-16 2018-10-23 MRI Interventions, Inc. MRI surgical systems including MRI-compatible surgical cannulae for transferring a substance to and/or from a patient
US9814885B2 (en) 2010-04-27 2017-11-14 Medtronic, Inc. Stimulation electrode selection
DE102010020152B4 (en) * 2010-05-11 2013-10-24 Siemens Aktiengesellschaft Device with local coil arrangement and implantable device
US10343283B2 (en) 2010-05-24 2019-07-09 Intouch Technologies, Inc. Telepresence robot system that can be accessed by a cellular phone
US10808882B2 (en) 2010-05-26 2020-10-20 Intouch Technologies, Inc. Tele-robotic system with a robot face placed on a chair
DE102010023844A1 (en) * 2010-06-15 2011-12-15 Siemens Aktiengesellschaft MR RF coils with modulable flexibility
WO2011158115A2 (en) * 2010-06-16 2011-12-22 A2 Surgical Method of determination of access areas from 3d patient images
US9264664B2 (en) 2010-12-03 2016-02-16 Intouch Technologies, Inc. Systems and methods for dynamic bandwidth allocation
KR20140040094A (en) 2011-01-28 2014-04-02 인터치 테크놀로지스 인코퍼레이티드 Interfacing with a mobile telepresence robot
US9323250B2 (en) 2011-01-28 2016-04-26 Intouch Technologies, Inc. Time-dependent navigation of telepresence robots
EP2675353A2 (en) * 2011-02-17 2013-12-25 MRI Interventions, Inc. Thin-sleeve apparatus for reducing rf coupling of devices in mri environments
KR101875122B1 (en) * 2011-02-25 2018-07-11 주식회사 칼라세븐 A Light therapy system using sunlight
EP2494936A3 (en) * 2011-03-03 2012-09-19 Imris Inc. MR compatible optical viewing device for use in the bore of an MR magnet
WO2012127345A1 (en) * 2011-03-18 2012-09-27 Koninklijke Philips Electronics N.V. Tracking brain deformation during neurosurgery
WO2012137179A1 (en) * 2011-04-08 2012-10-11 Monteris Medical, Inc. Head fixation system and method
US8406890B2 (en) * 2011-04-14 2013-03-26 Medtronic, Inc. Implantable medical devices storing graphics processing data
US10058267B2 (en) 2011-04-15 2018-08-28 Neocoil, Llc Antenna support structure for magnetic resonance imaging
US10769739B2 (en) 2011-04-25 2020-09-08 Intouch Technologies, Inc. Systems and methods for management of information among medical providers and facilities
US9098611B2 (en) 2012-11-26 2015-08-04 Intouch Technologies, Inc. Enhanced video interaction for a user interface of a telepresence network
US20140139616A1 (en) 2012-01-27 2014-05-22 Intouch Technologies, Inc. Enhanced Diagnostics for a Telepresence Robot
DE102011079565B4 (en) * 2011-07-21 2022-09-15 Siemens Healthcare Gmbh Direct connection head coil with height adjustment for e.g. Bechterew patients
TWI442905B (en) * 2011-09-30 2014-07-01 Univ Nat Chiao Tung Apparatus for locating the target of the stimulation
US8836751B2 (en) 2011-11-08 2014-09-16 Intouch Technologies, Inc. Tele-presence system with a user interface that displays different communication links
WO2013084107A2 (en) * 2011-12-05 2013-06-13 Koninklijke Philips Electronics N.V. Positioning and orientation of surgical tools during patient specific port placement
JP6130856B2 (en) 2012-01-03 2017-05-17 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． Position determination device
TWI463964B (en) * 2012-03-03 2014-12-11 Univ China Medical System and apparatus for an image guided navigation system in surgery
US9251313B2 (en) 2012-04-11 2016-02-02 Intouch Technologies, Inc. Systems and methods for visualizing and managing telepresence devices in healthcare networks
US8902278B2 (en) 2012-04-11 2014-12-02 Intouch Technologies, Inc. Systems and methods for visualizing and managing telepresence devices in healthcare networks
EP2666428B1 (en) * 2012-05-21 2015-10-28 Universität Bern System and method for estimating the spatial position of a tool within an object
EP2852881A4 (en) 2012-05-22 2016-03-23 Intouch Technologies Inc Graphical user interfaces including touchpad driving interfaces for telemedicine devices
US9361021B2 (en) 2012-05-22 2016-06-07 Irobot Corporation Graphical user interfaces including touchpad driving interfaces for telemedicine devices
US9192393B2 (en) 2012-05-31 2015-11-24 MRI Interventions, Inc. MRI compatible surgical drills and related methods
US9498290B2 (en) 2012-07-19 2016-11-22 MRI Interventions, Inc. Surgical navigation devices and methods
US9610048B2 (en) 2012-08-09 2017-04-04 MRI Interventions, Inc. Fiber optic systems for MRI suites and related devices and methods
CA2893369A1 (en) * 2012-08-24 2014-02-27 University Of Houston Robotic device and systems for image-guided and robot-assisted surgery
US10136955B2 (en) * 2012-08-24 2018-11-27 University Of Houston System Robotic device for image-guided surgery and interventions
US9192446B2 (en) 2012-09-05 2015-11-24 MRI Interventions, Inc. Trajectory guide frame for MRI-guided surgeries
CN203101610U (en) * 2012-09-25 2013-07-31 西门子(深圳)磁共振有限公司 Receiving coil of magnetic resonance system
US20140188440A1 (en) 2012-12-31 2014-07-03 Intuitive Surgical Operations, Inc. Systems And Methods For Interventional Procedure Planning
US9078588B2 (en) 2013-03-08 2015-07-14 MRI Interventions, Inc. MRI compatible intrabody stylets and related methods and systems
US9730762B2 (en) 2013-03-15 2017-08-15 Neocoil, Llc Automatic needle insertion location identification
CA2899359C (en) * 2013-03-15 2017-01-17 Synaptive Medical (Barbados) Inc. Planning, navigation and simulation systems and methods for minimally invasive therapy
US9222996B2 (en) * 2013-03-15 2015-12-29 The Brigham And Women's Hospital, Inc. Needle placement manipulator with two rotary guides
US10274553B2 (en) * 2013-03-15 2019-04-30 Canon U.S.A., Inc. Needle placement manipulator with attachment for RF-coil
CN105050525B (en) * 2013-03-15 2018-07-31 直观外科手术操作公司 Shape sensor system and application method for tracking intervention apparatus
US9782198B2 (en) * 2013-03-28 2017-10-10 Koninklijke Philips N.V. Localization of robotic remote center of motion point using custom trocar
CN103340685A (en) * 2013-06-27 2013-10-09 苏州边枫电子科技有限公司 Auxiliary needle feeding device of pneumatic type puncture needle
JP6603656B2 (en) 2013-07-02 2019-11-06 サージカル インフォメーション サイエンシズ インコーポレイテッド Method and system for predicting the position and shape of brain image pipelines and brain image regions
CA2918879A1 (en) 2013-07-24 2015-01-29 Centre For Surgical Invention & Innovation Multi-function mounting interface for an image-guided robotic system and quick release interventional toolset
US9891296B2 (en) 2013-09-13 2018-02-13 MRI Interventions, Inc. Intrabody fluid transfer devices, systems and methods
CA2924230C (en) * 2013-09-18 2020-03-31 iMIRGE Medical INC. Optical targeting and visusalization of trajectories
CN105934198A (en) * 2013-10-25 2016-09-07 西门子公司 Magnetic resonance coil unit and method for its manufacture
CN103646182B (en) * 2013-12-13 2018-11-02 陕西理工学院 A kind of application process of flexibility dynamic and visual technology on the medical image
US10595744B2 (en) 2014-02-14 2020-03-24 MRI Interventions, Inc. Surgical tool-positioning devices and related methods
JP6467434B2 (en) 2014-02-27 2019-02-13 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Mounting device
US10251670B2 (en) 2014-05-09 2019-04-09 Canon U.S.A., Inc. Positioning apparatus
CA2960189C (en) 2014-09-05 2021-11-23 Hyperfine Research, Inc. Low field magnetic resonance imaging methods and apparatus
US10866291B2 (en) * 2014-09-12 2020-12-15 Emory University Devices and systems for MRI-guided procedures
WO2016040817A1 (en) 2014-09-12 2016-03-17 Canon U.S.A., Inc. Needle positioning apparatus
WO2016077417A1 (en) 2014-11-11 2016-05-19 Hyperfine Research, Inc. Low field magnetic resonance methods and apparatus
WO2016115503A1 (en) 2015-01-16 2016-07-21 Voyager Therapeutics, Inc. Central nervous system targeting polynucleotides
US10542961B2 (en) 2015-06-15 2020-01-28 The Research Foundation For The State University Of New York System and method for infrasonic cardiac monitoring
US10420626B2 (en) 2015-06-30 2019-09-24 Canon U.S.A., Inc. Fiducial markers, systems, and methods of registration
WO2017003453A1 (en) * 2015-06-30 2017-01-05 Canon U.S.A., Inc. Fiducial markers, systems, and methods of registration
US9867673B2 (en) 2015-07-14 2018-01-16 Canon U.S.A, Inc. Medical support device
US10639065B2 (en) 2015-07-21 2020-05-05 Canon U.S.A., Inc. Medical assist device
US10324594B2 (en) * 2015-10-30 2019-06-18 Siemens Healthcare Gmbh Enterprise protocol management
US10905496B2 (en) * 2015-11-16 2021-02-02 Think Surgical, Inc. Method for confirming registration of tracked bones
CN108292527A (en) * 2015-11-30 2018-07-17 皇家飞利浦有限公司 The system of clinical discovery wheel disc-exploration clinical concept
JP6906239B2 (en) * 2015-12-28 2021-07-21 ザクト ロボティクス リミテッド Adjustable registration frame
USD829904S1 (en) 2016-01-13 2018-10-02 MRI Interventions, Inc. Curved bracket for surgical navigation systems
USD824027S1 (en) 2016-01-13 2018-07-24 MRI Interventions, Inc. Fins for a support column for a surgical trajectory frame
US10376333B2 (en) 2016-01-14 2019-08-13 MRI Interventions, Inc. Devices for surgical navigation systems
JP6630835B2 (en) 2016-01-29 2020-01-15 キヤノン ユーエスエイ，インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ．Ａ．，Ｉｎｃ Tool placement manipulator
CN105726124B (en) * 2016-02-06 2019-01-15 齐欣 Near end of thighbone location of operation orientation system and preparation method thereof
EP3393571B1 (en) 2016-02-17 2024-03-06 ClearPoint Neuro, Inc. Intrabody surgical fluid transfer assemblies with adjustable exposed cannula to needle tip length, related systems and methods
CN109106454B (en) * 2016-05-31 2020-09-22 万伟东 RC intracranial minimally invasive treatment positioning device
CN106175893B (en) * 2016-08-03 2018-10-30 福建医科大学附属第一医院 A kind of device of arching trajectory implantation intracranial electrode
CN106137283B (en) * 2016-08-27 2018-08-17 天津大学 A kind of natural cavity apparatus work rotary switch with regulatory function
DE102016216203A1 (en) * 2016-08-29 2017-09-14 Siemens Healthcare Gmbh Medical imaging system
JP6948389B2 (en) 2016-10-19 2021-10-13 キヤノン ユーエスエイ, インコーポレイテッドCanon U.S.A., Inc Placement manipulators and attachments for positioning puncture devices
US10539637B2 (en) 2016-11-22 2020-01-21 Hyperfine Research, Inc. Portable magnetic resonance imaging methods and apparatus
US10627464B2 (en) 2016-11-22 2020-04-21 Hyperfine Research, Inc. Low-field magnetic resonance imaging methods and apparatus
US11842030B2 (en) 2017-01-31 2023-12-12 Medtronic Navigation, Inc. Method and apparatus for image-based navigation
CN106618507A (en) * 2017-03-13 2017-05-10 北京理工大学 Touch cerebration stimulation device and fine adjustment assembly
WO2018167246A1 (en) * 2017-03-15 2018-09-20 Orthotaxy System for guiding a surgical tool relative to a target axis in spine surgery
EP3613057A4 (en) * 2017-04-18 2021-04-21 Intuitive Surgical Operations, Inc. Graphical user interface for planning a procedure
US11862302B2 (en) 2017-04-24 2024-01-02 Teladoc Health, Inc. Automated transcription and documentation of tele-health encounters
US11690645B2 (en) 2017-05-03 2023-07-04 Medtronic Vascular, Inc. Tissue-removing catheter
CN114948106A (en) 2017-05-03 2022-08-30 美敦力瓦斯科尔勒公司 Tissue removal catheter with guidewire isolation bushing
US10548674B2 (en) * 2017-07-06 2020-02-04 YellowDot Innovations, LLC Robotic guide for medical device
US10483007B2 (en) 2017-07-25 2019-11-19 Intouch Technologies, Inc. Modular telehealth cart with thermal imaging and touch screen user interface
US11512327B2 (en) 2017-08-03 2022-11-29 Voyager Therapeutics, Inc. Compositions and methods for delivery of AAV
US11202652B2 (en) 2017-08-11 2021-12-21 Canon U.S.A., Inc. Registration and motion compensation for patient-mounted needle guide
US10987016B2 (en) * 2017-08-23 2021-04-27 The Boeing Company Visualization system for deep brain stimulation
US11636944B2 (en) 2017-08-25 2023-04-25 Teladoc Health, Inc. Connectivity infrastructure for a telehealth platform
CN109620407B (en) * 2017-10-06 2024-02-06 皇家飞利浦有限公司 Treatment trajectory guidance system
US10893911B2 (en) 2017-11-26 2021-01-19 Canon U.S.A., Inc. Automated image cropping for enhanced automatic device-to-image registration
WO2019168973A1 (en) * 2018-02-27 2019-09-06 The Regents Of The University Of Colorado, A Body Corporate Robotic stereotaxic platform with computer vision
FR3078879B1 (en) * 2018-03-14 2020-03-06 Assistance Publique Hopitaux De Paris SURGICAL KIT TO BE USED DURING A CRANIECTOMY PROCEDURE
US10617299B2 (en) 2018-04-27 2020-04-14 Intouch Technologies, Inc. Telehealth cart that supports a removable tablet with seamless audio/video switching
EP3781074A1 (en) 2018-05-09 2021-02-24 ClearPoint Neuro, Inc. Mri compatible intrabody fluid transfer systems and related devices and methods
US11253237B2 (en) 2018-05-09 2022-02-22 Clearpoint Neuro, Inc. MRI compatible intrabody fluid transfer systems and related devices and methods
EP3793616A1 (en) 2018-05-15 2021-03-24 Voyager Therapeutics, Inc. Compositions and methods for delivery of aav
US20210198691A1 (en) 2018-05-15 2021-07-01 Voyager Therapeutics, Inc. Compositions and methods for the treatment of parkinson's disease
US11209509B2 (en) * 2018-05-16 2021-12-28 Viewray Technologies, Inc. Resistive electromagnet systems and methods
WO2019222444A2 (en) 2018-05-16 2019-11-21 Voyager Therapeutics, Inc. Directed evolution
CN108814658B (en) * 2018-06-27 2021-10-01 中国人民解放军陆军军医大学第三附属医院（野战外科研究所） Craniotomy device and craniotomy method
SG11202100704PA (en) 2018-07-24 2021-02-25 Voyager Therapeutics Inc Systems and methods for producing gene therapy formulations
US20210371470A1 (en) 2018-10-12 2021-12-02 Voyager Therapeutics, Inc. Compositions and methods for delivery of aav
EP3880096A1 (en) 2018-11-16 2021-09-22 Medtronic Vascular Inc. Tissue-removing catheter
US11744655B2 (en) 2018-12-04 2023-09-05 Globus Medical, Inc. Drill guide fixtures, cranial insertion fixtures, and related methods and robotic systems
US11364086B2 (en) 2019-02-01 2022-06-21 Advanced Neuromodulation Systems, Inc. Trajectory guide with dual arc arrangement
US11298204B2 (en) * 2019-02-01 2022-04-12 Advanced Neuromodulation Systems, Inc. Trajectory guide with dual gimbal drive arrangement
US11406470B2 (en) 2019-02-01 2022-08-09 Advanced Neuromodulation Systems, Inc. Trajectory guide with double X-Y sliding tables
SG11202109927YA (en) * 2019-03-25 2021-10-28 Promaxo Inc Single-sided fast mri gradient field coils and applications thereof
US11819236B2 (en) 2019-05-17 2023-11-21 Medtronic Vascular, Inc. Tissue-removing catheter
WO2021046155A1 (en) 2019-09-03 2021-03-11 Voyager Therapeutics, Inc. Vectorized editing of nucleic acids to correct overt mutations
US11684750B2 (en) 2019-10-08 2023-06-27 Clearpoint Neuro, Inc. Extension tube assembly and related medical fluid transfer systems and methods
US11925418B2 (en) 2019-12-02 2024-03-12 The General Hospital Corporation Methods for multi-modal bioimaging data integration and visualization
US20230056943A1 (en) * 2019-12-13 2023-02-23 Dinesh Vyas Stapler apparatus and methods for use
EP4041105A1 (en) 2019-12-19 2022-08-17 ClearPoint Neuro, Inc. Front-loadable fluid transfer assemblies and related medical fluid transfer systems
US11602400B2 (en) * 2020-01-10 2023-03-14 Stryker European Operations Limited Surgical arm and method of providing visual guidance for operating same
US11925511B2 (en) 2020-01-31 2024-03-12 Clearpoint Neuro, Inc. Surgical tool support systems including elongate support legs with adjustable lengths and related methods
WO2021183295A2 (en) * 2020-03-12 2021-09-16 Clearpoint Neuro, Inc. Image-guided surgical systems with automated trajectory guide systems and related devices and methods
TWI737404B (en) * 2020-07-15 2021-08-21 臺北醫學大學 Medical image processing system and method thereof
CN113940754B (en) * 2020-07-15 2024-03-22 台北医学大学 Medical image processing system and method
US11238591B1 (en) 2020-07-15 2022-02-01 Taipei Medical University (Tmu) Medical image processing system and method thereof
US20220296308A1 (en) * 2021-03-16 2022-09-22 Clearpoint Neuro, Inc. Directional-device intrabody placement systems and related methods
WO2022212793A1 (en) * 2021-03-31 2022-10-06 Clear Guide Medical, Inc. System and method for image guided interventions
CN113764074B (en) * 2021-09-13 2024-01-02 杭州太美星程医药科技有限公司 Image processing method and device, computer equipment and storage medium

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2697433A (en) 1951-12-04 1954-12-21 Max A Zehnder Device for accurately positioning and guiding guide wires used in the nailing of thefemoral neck
US3878830A (en) * 1973-05-31 1975-04-22 Mediscience Technology Corp Catheter system for blood gas monitoring
US4051845A (en) * 1976-03-05 1977-10-04 The Kendall Company Drape assembly with pouch and method
US4386602A (en) 1977-05-17 1983-06-07 Sheldon Charles H Intracranial surgical operative apparatus
US4209258A (en) * 1978-02-14 1980-06-24 Oakes W Peter Automatic continuous mixer apparatus
US4319136A (en) 1979-11-09 1982-03-09 Jinkins J Randolph Computerized tomography radiograph data transfer cap
US4276697A (en) * 1980-04-21 1981-07-07 Astek Engineering, Inc. Compliance element for remote center compliance unit
US4838265A (en) 1985-05-24 1989-06-13 Cosman Eric R Localization device for probe placement under CT scanner imaging
US5085219A (en) * 1987-10-30 1992-02-04 The Regents Of The University Of California Adjustable holders for magnetic reasonance imaging rf surface coil
DE3804491A1 (en) * 1987-12-02 1989-06-15 Olympus Optical Co Device for brain surgery
JPH0252642A (en) 1988-08-17 1990-02-22 Olympus Optical Co Ltd Brain operation equipment
JPH0298335A (en) * 1988-10-04 1990-04-10 Toshiba Corp Treatment portion positioning mechanism for magnetic resonance imaging
US5125888A (en) 1990-01-10 1992-06-30 University Of Virginia Alumni Patents Foundation Magnetic stereotactic system for treatment delivery
US6006126A (en) 1991-01-28 1999-12-21 Cosman; Eric R. System and method for stereotactic registration of image scan data
JPH0584309A (en) 1991-09-27 1993-04-06 Olympus Optical Co Ltd Water supply connector device of medical instrument
US5469847A (en) 1992-09-09 1995-11-28 Izi Corporation Radiographic multi-modality skin markers
US5342356A (en) 1992-12-02 1994-08-30 Ellman Alan G Electrical coupling unit for electrosurgery
US5799099A (en) 1993-02-12 1998-08-25 George S. Allen Automatic technique for localizing externally attached fiducial markers in volume images of the head
US6419680B1 (en) 1993-06-10 2002-07-16 Sherwood Services Ag CT and MRI visible index markers for stereotactic localization
US5469353A (en) 1993-11-26 1995-11-21 Access Radiology Corp. Radiological image interpretation apparatus and method
US5450293A (en) * 1993-12-30 1995-09-12 Hoffman; Elliott S. Finger mounted fiber optic illumination system
US5537704A (en) * 1994-07-19 1996-07-23 Ohio Medical Instrument Company, Inc. Radiolucent head clamp
US5803089A (en) 1994-09-15 1998-09-08 Visualization Technology, Inc. Position tracking and imaging system for use in medical applications
US5728079A (en) 1994-09-19 1998-03-17 Cordis Corporation Catheter which is visible under MRI
US5695501A (en) 1994-09-30 1997-12-09 Ohio Medical Instrument Company, Inc. Apparatus for neurosurgical stereotactic procedures
US5971997A (en) 1995-02-03 1999-10-26 Radionics, Inc. Intraoperative recalibration apparatus for stereotactic navigators
US5971984A (en) 1995-03-01 1999-10-26 Smith & Nephew, Inc. Method of using an orthopaedic fixation device
US5699801A (en) 1995-06-01 1997-12-23 The Johns Hopkins University Method of internal magnetic resonance imaging and spectroscopic analysis and associated apparatus
US5697958A (en) 1995-06-07 1997-12-16 Intermedics, Inc. Electromagnetic noise detector for implantable medical devices
US5638819A (en) 1995-08-29 1997-06-17 Manwaring; Kim H. Method and apparatus for guiding an instrument to a target
US5855582A (en) 1995-12-19 1999-01-05 Gildenberg; Philip L. Noninvasive stereotactic apparatus and method for relating data between medical devices
US5800353A (en) 1996-02-12 1998-09-01 Mclaurin, Jr.; Robert L. Automatic image registration of magnetic resonance imaging scans for localization, 3-dimensional treatment planning, and radiation treatment of abnormal lesions
US5735278A (en) 1996-03-15 1998-04-07 National Research Council Of Canada Surgical procedure with magnetic resonance imaging
US6628980B2 (en) 2000-03-24 2003-09-30 Surgi-Vision, Inc. Apparatus, systems, and methods for in vivo magnetic resonance imaging
US5928145A (en) 1996-04-25 1999-07-27 The Johns Hopkins University Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus employing a loopless antenna
US6263229B1 (en) 1998-11-13 2001-07-17 Johns Hopkins University School Of Medicine Miniature magnetic resonance catheter coils and related methods
US6675033B1 (en) 1999-04-15 2004-01-06 Johns Hopkins University School Of Medicine Magnetic resonance imaging guidewire probe
DE19618945C2 (en) 1996-05-10 2003-02-27 Phonak Ag Staefa Fixable positioning system for a firm, play-free connection to the human skull
DE19625834A1 (en) 1996-06-27 1998-01-02 Siemens Ag Medical system architecture
US6177797B1 (en) * 1996-12-19 2001-01-23 Advanced Imaging Research, Inc. Radio-frequency coil and method for resonance/imaging analysis
US5961455A (en) 1996-12-31 1999-10-05 Daum Gmbh Device for positioning a medical instrument and method
US6752812B1 (en) 1997-05-15 2004-06-22 Regent Of The University Of Minnesota Remote actuation of trajectory guide
US5993463A (en) 1997-05-15 1999-11-30 Regents Of The University Of Minnesota Remote actuation of trajectory guide
JP2001525703A (en) 1997-05-15 2001-12-11 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Method and apparatus for targeted dosing of patients using magnetic resonance imaging
US6267769B1 (en) 1997-05-15 2001-07-31 Regents Of The Universitiy Of Minnesota Trajectory guide method and apparatus for use in magnetic resonance and computerized tomographic scanners
US6050992A (en) 1997-05-19 2000-04-18 Radiotherapeutics Corporation Apparatus and method for treating tissue with multiple electrodes
SE9800126D0 (en) 1998-01-20 1998-01-20 Pacesetter Ab Implantable medical device
US6360116B1 (en) 1998-02-27 2002-03-19 Varian Medical Systems, Inc. Brachytherapy system for prostate cancer treatment with computer implemented systems and processes to facilitate pre-operative planning and post-operative evaluations
US6298262B1 (en) 1998-04-21 2001-10-02 Neutar, Llc Instrument guidance for stereotactic surgery
US6273896B1 (en) 1998-04-21 2001-08-14 Neutar, Llc Removable frames for stereotactic localization
US6529765B1 (en) 1998-04-21 2003-03-04 Neutar L.L.C. Instrumented and actuated guidance fixture for sterotactic surgery
US6546277B1 (en) * 1998-04-21 2003-04-08 Neutar L.L.C. Instrument guidance system for spinal and other surgery
FR2779339B1 (en) 1998-06-09 2000-10-13 Integrated Surgical Systems Sa MATCHING METHOD AND APPARATUS FOR ROBOTIC SURGERY, AND MATCHING DEVICE COMPRISING APPLICATION
US6459927B1 (en) 1999-07-06 2002-10-01 Neutar, Llc Customizable fixture for patient positioning
US6351662B1 (en) 1998-08-12 2002-02-26 Neutar L.L.C. Movable arm locator for stereotactic surgery
US6282437B1 (en) 1998-08-12 2001-08-28 Neutar, Llc Body-mounted sensing system for stereotactic surgery
US6117143A (en) 1998-09-11 2000-09-12 Hybex Surgical Specialties, Inc. Apparatus for frameless stereotactic surgery
US6954802B2 (en) * 1998-09-29 2005-10-11 Tdk Electronics Corporation Removable media recording station for the medical industry
US20050240445A1 (en) 1998-09-29 2005-10-27 Michael Sutherland Medical archive library and method
US6195577B1 (en) 1998-10-08 2001-02-27 Regents Of The University Of Minnesota Method and apparatus for positioning a device in a body
US7844319B2 (en) 1998-11-04 2010-11-30 Susil Robert C Systems and methods for magnetic-resonance-guided interventional procedures
US6701176B1 (en) 1998-11-04 2004-03-02 Johns Hopkins University School Of Medicine Magnetic-resonance-guided imaging, electrophysiology, and ablation
US6198961B1 (en) * 1998-11-12 2001-03-06 Picker International, Inc. Interventional radio frequency coil assembly for magnetic resonance (MR) guided neurosurgery
WO2000028900A1 (en) * 1998-11-17 2000-05-25 Metra Biosystems, Inc. Test object geometry for ultrasound transmission calibration
US6198962B1 (en) * 1998-11-25 2001-03-06 Toshiba America Mri, Inc. Quadrature detection coil for interventional MRI
US6284971B1 (en) 1998-11-25 2001-09-04 Johns Hopkins University School Of Medicine Enhanced safety coaxial cables
US6798206B2 (en) * 1998-11-25 2004-09-28 Medrad, Inc. Neurovascular coil system and interface and system therefor and method of operating same in a multitude of modes
US6470207B1 (en) 1999-03-23 2002-10-22 Surgical Navigation Technologies, Inc. Navigational guidance via computer-assisted fluoroscopic imaging
US7848788B2 (en) 1999-04-15 2010-12-07 The Johns Hopkins University Magnetic resonance imaging probe
US6491699B1 (en) 1999-04-20 2002-12-10 Surgical Navigation Technologies, Inc. Instrument guidance method and system for image guided surgery
US6539263B1 (en) 1999-06-11 2003-03-25 Cornell Research Foundation, Inc. Feedback mechanism for deep brain stimulation
US6167311A (en) 1999-06-14 2000-12-26 Electro Core Techniques, Llc Method of treating psychological disorders by brain stimulation within the thalamus
US20030205233A1 (en) * 1999-12-02 2003-11-06 A-Med Systems, Inc. Surgical drape and panel assembly
JP2001161660A (en) * 1999-12-10 2001-06-19 Hitachi Medical Corp Magnetic resonance imaging system
DK200001852A (en) 1999-12-14 2001-06-15 Asahi Optical Co Ltd Manipulation section for an endoscopic treatment instrument
US6356786B1 (en) 2000-01-20 2002-03-12 Electrocore Techniques, Llc Method of treating palmar hyperhydrosis by electrical stimulation of the sympathetic nervous chain
US6438423B1 (en) 2000-01-20 2002-08-20 Electrocore Technique, Llc Method of treating complex regional pain syndromes by electrical stimulation of the sympathetic nerve chain
AU2001238012A1 (en) 2000-02-01 2001-08-14 Surgi-Vision, Inc. Magnetic resonance imaging transseptal needle antenna
US6609030B1 (en) 2000-02-24 2003-08-19 Electrocore Techniques, Llc Method of treating psychiatric diseases by neuromodulation within the dorsomedial thalamus
US6708064B2 (en) 2000-02-24 2004-03-16 Ali R. Rezai Modulation of the brain to affect psychiatric disorders
WO2001064124A1 (en) 2000-03-01 2001-09-07 Surgical Navigation Technologies, Inc. Multiple cannula image guided tool for image guided procedures
US6477399B2 (en) 2000-03-29 2002-11-05 Mcw Research Foundation, Inc. Method for determining the reliability of fMRI parameters
DE10015670A1 (en) * 2000-03-29 2001-10-11 Forschungszentrum Juelich Gmbh Head holder has arrangement for holding head in one position and at least three markers. whose positions can be freely selected in non-symmetrical arrangement with respect to each other
US6315783B1 (en) * 2000-04-07 2001-11-13 Odin Technologies, Ltd. Surgical head support
US7366561B2 (en) 2000-04-07 2008-04-29 Medtronic, Inc. Robotic trajectory guide
US7660621B2 (en) 2000-04-07 2010-02-09 Medtronic, Inc. Medical device introducer
US6575904B2 (en) * 2000-05-09 2003-06-10 Matsushita Electric Industrial Co., Ltd. Biodata interfacing system
US6526318B1 (en) 2000-06-16 2003-02-25 Mehdi M. Ansarinia Stimulation method for the sphenopalatine ganglia, sphenopalatine nerve, or vidian nerve for treatment of medical conditions
DE10029737B4 (en) 2000-06-23 2006-01-19 Mri Devices Daum Gmbh Navigation of a medical instrument
DE10029736B4 (en) 2000-06-23 2004-05-06 Mri Devices Daum Gmbh Minimally invasive neurosurgery access
US6902569B2 (en) 2000-08-17 2005-06-07 Image-Guided Neurologics, Inc. Trajectory guide with instrument immobilizer
US6712773B1 (en) 2000-09-11 2004-03-30 Tyco Healthcare Group Lp Biopsy system
US6405079B1 (en) 2000-09-22 2002-06-11 Mehdi M. Ansarinia Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions
US6577888B1 (en) * 2000-09-29 2003-06-10 Usa Instruments, Inc. Sliding-dome and split-top MRI radio frequency quadrature array coil system
US6591128B1 (en) 2000-11-09 2003-07-08 Koninklijke Philips Electronics, N.V. MRI RF coil systems having detachable, relocatable, and or interchangeable sections and MRI imaging systems and methods employing the same
DE60041893D1 (en) 2000-11-24 2009-05-07 Kent Ridge Digital Labs METHOD AND DEVICES FOR PROCESSING MEDICAL IMAGES
EP1395306B1 (en) 2001-05-21 2006-05-31 Medtronic, Inc. Malleable elongated medical device
FI110478B (en) 2001-05-29 2003-02-14 Planmeca Oy Method and apparatus for defining a beam
US7532920B1 (en) * 2001-05-31 2009-05-12 Advanced Cardiovascular Systems, Inc. Guidewire with optical fiber
US20030055436A1 (en) 2001-09-14 2003-03-20 Wolfgang Daum Navigation of a medical instrument
US6772000B2 (en) 2001-10-19 2004-08-03 Scimed Life Systems, Inc. Magnetic resonance imaging devices with a contrast medium for improved imaging
US7020844B2 (en) 2001-11-21 2006-03-28 General Electric Company Method and apparatus for managing workflow in prescribing and processing medical images
WO2003049032A2 (en) 2001-12-07 2003-06-12 Koninklijke Philips Electronics N.V. Medical viewing system and method for spatially enhancing structures in noisy images
US20040092810A1 (en) 2002-02-14 2004-05-13 Wolfgang Daum Method and apparatus for MR-guided biopsy
EP1501411B1 (en) 2002-04-22 2014-03-12 Johns Hopkins University Apparatus for insertion of a medical device during a medical imaging process
US6725092B2 (en) 2002-04-25 2004-04-20 Biophan Technologies, Inc. Electromagnetic radiation immune medical assist device adapter
US7022082B2 (en) 2002-05-13 2006-04-04 Sonek Jiri D Needle guide systems and methods
US7894877B2 (en) 2002-05-17 2011-02-22 Case Western Reserve University System and method for adjusting image parameters based on device tracking
EP1508051A1 (en) 2002-05-29 2005-02-23 Surgi-Vision, Inc. Magnetic resonance probes
EP1550024A2 (en) 2002-06-21 2005-07-06 Cedara Software Corp. Computer assisted system and method for minimal invasive hip, uni knee and total knee replacement
US6978167B2 (en) 2002-07-01 2005-12-20 Claron Technology Inc. Video pose tracking system and method
US7720522B2 (en) 2003-02-25 2010-05-18 Medtronic, Inc. Fiducial marker devices, tools, and methods
CA2437286C (en) 2002-08-13 2008-04-29 Garnette Roy Sutherland Microsurgical robot system
AU2003275402A1 (en) * 2002-09-30 2004-04-19 Stereotaxis, Inc. A method and apparatus for improved surgical navigation employing electronic indentification with automatically actuated flexible medical devices
US20060173283A1 (en) 2002-11-27 2006-08-03 Oskar Axelsson Method of magnetic resonance imaging
US7636596B2 (en) 2002-12-20 2009-12-22 Medtronic, Inc. Organ access device and method
EP2319405B1 (en) 2003-01-24 2013-09-18 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
US7896889B2 (en) 2003-02-20 2011-03-01 Medtronic, Inc. Trajectory guide with angled or patterned lumens or height adjustment
US7559935B2 (en) 2003-02-20 2009-07-14 Medtronic, Inc. Target depth locators for trajectory guide for introducing an instrument
US7203551B2 (en) 2003-04-25 2007-04-10 Medtronic, Inc. Implantable lead-based sensor powered by piezoelectric transformer
US7167760B2 (en) 2003-04-28 2007-01-23 Vanderbilt University Apparatus and methods of optimal placement of deep brain stimulator
US20050054910A1 (en) 2003-07-14 2005-03-10 Sunnybrook And Women's College Health Sciences Centre Optical image-based position tracking for magnetic resonance imaging applications
US7313430B2 (en) 2003-08-28 2007-12-25 Medtronic Navigation, Inc. Method and apparatus for performing stereotactic surgery
EP1673146B1 (en) * 2003-09-30 2012-11-14 Koninklijke Philips Electronics N.V. Target tracking apparatus for radiation treatment planning and delivery
JP2005137498A (en) 2003-11-05 2005-06-02 Sanko Sangyo Co Ltd Holder
US20050131522A1 (en) 2003-12-10 2005-06-16 Stinson Jonathan S. Medical devices and methods of making the same
US8620406B2 (en) 2004-01-23 2013-12-31 Boston Scientific Scimed, Inc. Medical devices visible by magnetic resonance imaging
US7174219B2 (en) 2004-03-30 2007-02-06 Medtronic, Inc. Lead electrode for use in an MRI-safe implantable medical device
EP1761174B1 (en) 2004-05-21 2009-10-07 Ethicon Endo-Surgery, Inc. Mri biopsy apparatus incorporating an imagable penetrating portion
US6939165B1 (en) * 2004-07-22 2005-09-06 Hon Hai Precision Ind. Co., Ltd. Cable connector assembly with cable holder
JP5288797B2 (en) 2004-07-27 2013-09-11 エムアールアイ・インターヴェンションズ，インコーポレイテッド MRI system having an MRI-compatible universal supply cannula with a cooperating MRI antenna probe and related systems
CN101039619B (en) 2004-08-09 2010-06-16 约翰斯·霍普金斯大学 Implantable MRI compatible stimulation leads and antennas and related systems and methods
EP1846181A2 (en) 2005-01-28 2007-10-24 Massachusetts General Hospital Guidance and insertion system
WO2006119492A2 (en) 2005-05-04 2006-11-09 Surgi-Vision, Inc. Improved electrical lead for an electronic device such as an implantable device
US7869858B2 (en) * 2005-05-12 2011-01-11 General Electric Company Patient table system and apparatus
WO2007032341A1 (en) 2005-09-12 2007-03-22 Nemoto Kyorindo Co., Ltd. Medicinal liquid injection system
EP3492008B1 (en) * 2005-09-13 2021-06-02 Veran Medical Technologies, Inc. Apparatus and method for image guided accuracy verification
EP1945124A2 (en) 2005-11-07 2008-07-23 Vanderbilt University Adjustable universal surgical platform
AU2006320611A1 (en) * 2005-11-29 2007-06-07 Surgi-Vision, Inc. MRI-guided localization and/or lead placement systems, related methods, devices and computer program products
DE102005062716A1 (en) 2005-12-28 2007-07-05 Precisis Ag Stereotaxis frame for patient, is formed in anatomical form of skull cross-section that is oval and non-circular, rectangular or square to facilitate access to head coil in magnetic resonance imaging
CA2646363C (en) 2006-03-14 2015-07-21 The Johns Hopkins University Apparatus for insertion of a medical device within a body during a medical imaging process and devices and methods related thereto
US7359226B2 (en) * 2006-08-28 2008-04-15 Qimonda Ag Transistor, memory cell array and method for forming and operating a memory device
US8175677B2 (en) 2007-06-07 2012-05-08 MRI Interventions, Inc. MRI-guided medical interventional systems and methods
EP2194906B8 (en) 2007-09-24 2015-04-22 Mri Interventions, Inc. Mri-guided medical interventional system

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US10675113B2 (en) 2014-03-18 2020-06-09 Monteris Medical Corporation Automated therapy of a three-dimensional tissue region
US10327830B2 (en) 2015-04-01 2019-06-25 Monteris Medical Corporation Cryotherapy, thermal therapy, temperature modulation therapy, and probe apparatus therefor
US11672583B2 (en) 2015-04-01 2023-06-13 Monteris Medical Corporation Cryotherapy, thermal therapy, temperature modulation therapy, and probe apparatus therefor
US11298043B2 (en) 2016-08-30 2022-04-12 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
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US11497576B2 (en) 2017-07-17 2022-11-15 Voyager Therapeutics, Inc. Trajectory array guide system

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