CA2708573A1 - Cartridge for containing a specimen sample for optical analysis - Google Patents

Cartridge for containing a specimen sample for optical analysis Download PDF

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Publication number
CA2708573A1
CA2708573A1 CA2708573A CA2708573A CA2708573A1 CA 2708573 A1 CA2708573 A1 CA 2708573A1 CA 2708573 A CA2708573 A CA 2708573A CA 2708573 A CA2708573 A CA 2708573A CA 2708573 A1 CA2708573 A1 CA 2708573A1
Authority
CA
Canada
Prior art keywords
test chamber
seal
inlet
cartridge
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2708573A
Other languages
French (fr)
Other versions
CA2708573C (en
Inventor
Richard L. Columbus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Diagnostics LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2708573A1 publication Critical patent/CA2708573A1/en
Application granted granted Critical
Publication of CA2708573C publication Critical patent/CA2708573C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/11—Filling or emptying of cuvettes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Abstract

A cartridge (21) for holding a test specimen with an extremely small volume.
The cartridge has a test chamber (63) and a vestibule (66) through which the test fluids are inserted into the test chamber. The cartridge has a stopper (60) having a pair of seals (72, 74), the first of which seals the test chamber inlet (65) between the vestibule and the test chamber, and the second of which seals the mouth (67) of the vestibule so that when the stopper is in place, the test chamber is closed to the admission of air other contaminants and the vestibule is similarly closed against escape of the overflow from the test chamber.

Claims (4)

1. A cartridge containing a test chamber for use in apparatus for performing optical analysis of liquid specimens by optical observation, said apparatus having a receptacle for receiving the cartridge and positioning the test chamber of the cartridge in a field of observation of the apparatus to enable analysis of liquid within the test chamber, the apparatus having at least two magnetic poles positioned on opposite sides of the receptacle to apply a magnetic field to the cartridge, said cartridge comprising:
a body of translucent plastic adapted to be slidably engaged in the receptacle of the apparatus between said magnetic poles to position the test chamber in the magnetic field of said poles, said body having a domed cross section with a flat land area adapted to be positioned in the field of observation of the apparatus, a test chamber underlying said flat land area and having a longitudinal axis adapted to be disposed vertically when liquid is inserted therein, and having a vestibule above said test chamber, an inlet between said test chamber and said vestibule, and a fill line located adjacent said inlet, said fill line determined by the surface of liquid inserted into said test chamber;
a stopper having a first seal adapted to sealingly seat in the inlet and close the same, said stopper having a distal end adapted to enter the inlet of the test chamber below the fill line before the first seal closes said inlet, said distal end having a thickness sufficient to displace liquid upwardly through said inlet and position the surface of the liquid in said vestibule prior to said first seal closing said inlet, said first seal, upon being seated in the inlet, precluding air entrapment within the test chamber;
said vestibule having a volume to form an overflow reservoir for receiving a volume of liquid that may be displaced upon seating the primary seal; and a second seal remote form the first seal in said vestibule, said first and second seals defining therebetween the overflow reservoir, said second seal precluding migration of any overflow liquid past the second seal out of the cartridge.
2. A cartridge according to claim 1 wherein said test chamber has a volume of at least 315 µl and said vestibule has a volume of at least 95 µl when the first of said stopper seals is seated in the inlet and the second seal is precluding migration of any overflow liquid past the second seal.
3. A cartridge according to claim 1 wherein said test chamber has a volume in the range of 22 ml to 675 µl.
4. A cartridge according to claim 1 wherein said test chamber has a cross-sectional area in the range of 10 to 14 square millimeters and the inlet has a diameter of 2.35 mm.
CA2708573A 2001-02-12 2002-02-12 Cartridge for containing a specimen sample for optical analysis Expired - Fee Related CA2708573C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26810101P 2001-02-12 2001-02-12
US60/268,101 2001-02-12
CA2434604A CA2434604C (en) 2001-02-12 2002-02-12 Cartridge for containing a specimen sample for optical analysis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2434604A Division CA2434604C (en) 2001-02-12 2002-02-12 Cartridge for containing a specimen sample for optical analysis

Publications (2)

Publication Number Publication Date
CA2708573A1 true CA2708573A1 (en) 2002-08-22
CA2708573C CA2708573C (en) 2012-05-01

Family

ID=23021476

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2434604A Expired - Fee Related CA2434604C (en) 2001-02-12 2002-02-12 Cartridge for containing a specimen sample for optical analysis
CA2708573A Expired - Fee Related CA2708573C (en) 2001-02-12 2002-02-12 Cartridge for containing a specimen sample for optical analysis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2434604A Expired - Fee Related CA2434604C (en) 2001-02-12 2002-02-12 Cartridge for containing a specimen sample for optical analysis

Country Status (12)

Country Link
US (2) US6861259B2 (en)
EP (1) EP1360471B1 (en)
JP (1) JP3766064B2 (en)
KR (1) KR20030074816A (en)
CN (1) CN1491355A (en)
AT (1) ATE340360T1 (en)
AU (1) AU2002243968B2 (en)
BR (1) BR0207095A (en)
CA (2) CA2434604C (en)
DE (1) DE60214827T2 (en)
IL (1) IL156741A0 (en)
WO (1) WO2002065103A1 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7863012B2 (en) * 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
US7764821B2 (en) 2002-02-14 2010-07-27 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
AU2003219759B2 (en) 2002-02-14 2011-01-20 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
US7011794B2 (en) 2002-11-25 2006-03-14 Immunivest Corporation Upon a cartridge for containing a specimen sample for optical analysis
US7682833B2 (en) 2003-09-10 2010-03-23 Abbott Point Of Care Inc. Immunoassay device with improved sample closure
US20050181353A1 (en) * 2004-02-17 2005-08-18 Rao Galla C. Stabilization of cells and biological specimens for analysis
US8189899B2 (en) * 2004-07-30 2012-05-29 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
US7901950B2 (en) * 2005-08-12 2011-03-08 Veridex, Llc Method for assessing disease states by profile analysis of isolated circulating endothelial cells
US7777885B2 (en) * 2005-08-17 2010-08-17 Veridex, Llc Diagnostic imaging device for the analysis of circulating rare cells
JP5457673B2 (en) * 2005-09-20 2014-04-02 ベリデックス・リミテッド・ライアビリティ・カンパニー Methods and compositions for making unique sequence DNA probes, labeling of DNA probes, and use of these probes
US9134237B2 (en) * 2005-09-20 2015-09-15 Janssen Diagnotics, LLC High sensitivity multiparameter method for rare event analysis in a biological sample
US8337755B2 (en) * 2006-03-13 2012-12-25 Veridex, Llc Operator independent programmable sample preparation and analysis system
US7722822B2 (en) * 2006-03-23 2010-05-25 Agilent Technologies, Inc. Sample tube and vial processing system, and method for processing the sample
US8003314B2 (en) 2007-04-16 2011-08-23 Diagnostic Hybrids, Inc. Methods for direct fluorescent antibody virus detection in liquids
US8003060B2 (en) * 2007-05-18 2011-08-23 Axela Inc. Reaction vessel with integrated optical and fluid control elements
US8110101B2 (en) * 2007-08-30 2012-02-07 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US7828968B2 (en) 2007-08-30 2010-11-09 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US8758267B2 (en) * 2009-03-17 2014-06-24 Nova Biomedical Corporation Modified lancet carrier for single-use lancet sensor assembly
US8790916B2 (en) 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
WO2011071772A2 (en) * 2009-12-07 2011-06-16 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
CN103237901B (en) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 For treating the biomarker of diagnosis
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
CA2817283C (en) 2010-10-05 2020-07-14 Anpac Bio-Medical Science Co., Ltd. Micro-devices for disease detection
GB2488559A (en) * 2011-03-01 2012-09-05 Univ Bristol Apparatus for testing the quality of drinking water
WO2012128841A2 (en) 2011-03-24 2012-09-27 Anpac Bio-Medical Science Co., Ltd. Micro-devices for disease detection
WO2013016600A2 (en) 2011-07-28 2013-01-31 The Trustees Of The University Of Pennsylvania Methods and reagents for diagnosing conditions and characterization of tumor cells associated with serous fluids
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
CA2842359A1 (en) 2011-08-01 2013-02-07 Denovo Sciences Cell capture system and method of use
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
US9174216B2 (en) 2013-03-13 2015-11-03 DeNovo Science, Inc. System for capturing and analyzing cells
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
WO2014091321A1 (en) * 2012-12-13 2014-06-19 Koninklijke Philips N.V. Cartridge and apparatus for preparing a biological sample
US9606102B2 (en) 2013-01-26 2017-03-28 Denovo Sciences, Inc. System and method for capturing and analyzing cells
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
JP6551835B2 (en) * 2014-08-22 2019-07-31 パナソニックＩｐマネジメント株式会社 Socket, Adapter, and Assembly Jig
US9476875B2 (en) 2015-03-02 2016-10-25 Chembio Diagnostic Systems, Inc. Integrated buffer dual-path immunoassay device
DE102016104808A1 (en) 2016-03-15 2017-09-21 Als Automated Lab Solutions Gmbh Device for insertion into an imaging system
EP3651903A4 (en) 2017-08-29 2021-06-16 Bio-Rad Laboratories, Inc. System and method for isolating and analyzing cells
US11375986B1 (en) * 2018-07-27 2022-07-05 The University Of Chicago Device and method for stool sample collection
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
CN114072490A (en) 2019-05-07 2022-02-18 伯乐实验室有限公司 System and method for automated single cell processing
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
WO2020251802A1 (en) 2019-06-14 2020-12-17 Bio-Rad Laboratories, Inc. System and method for automated single cell processing and analyses
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124281A (en) 1964-03-10 stull
US3276640A (en) 1965-03-08 1966-10-04 Kessler Milton Closable pouring spout and an axially slidable cap moving a plug thereon for liquid containers
US4091802A (en) * 1976-02-17 1978-05-30 Eastman Kodak Company Vented liquid collection device
DE3036139A1 (en) 1980-09-25 1982-05-06 Hans 8801 Schillingsfürst Heinlein SPOUT FOR BOTTLE-LIKE CONTAINERS
US4559610A (en) * 1983-05-04 1985-12-17 Southwest Research Corporation Gas pumping system analog
IT8322185V0 (en) 1983-06-22 1983-06-22 Victor Wassilieff CLOSING DEVICE FOR FLUID CONTAINERS.
US4859610A (en) 1985-06-05 1989-08-22 Synbiotics Corporation Immunoassay incubation device
US4703865A (en) * 1985-06-10 1987-11-03 Bates William T D Sealing cap
US4933291A (en) 1986-12-22 1990-06-12 Eastman Kodak Company Centrifugable pipette tip and pipette therefor
US5089417A (en) 1987-07-01 1992-02-18 Miles Inc. Fluid separation and processing device
US4849173A (en) 1987-07-24 1989-07-18 Chang Mao Kuei Excrement examination unit
US5597733A (en) 1988-07-25 1997-01-28 Precision Systems, Inc. Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer
US5160702A (en) * 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
US5026526A (en) 1990-02-09 1991-06-25 Eastman Kodak Company Automated capping means for analyzer pipette
GB9013728D0 (en) 1990-06-20 1990-08-08 Waddington & Duval Ltd Improvements in and relating to dispensing taps
US5179862A (en) 1990-06-29 1993-01-19 Panametrics, Inc. Snap-on flow measurement system
US6013532A (en) 1990-09-26 2000-01-11 Immunivest Corporation Methods for magnetic immobilization and manipulation of cells
JPH0726701Y2 (en) 1991-03-08 1995-06-14 東洋製罐株式会社 Sample collection container
US5149506A (en) 1991-08-09 1992-09-22 Sage Products, Inc. Stool collection and transport device
US5242660A (en) * 1992-02-28 1993-09-07 Paul Hsei Sample preparation device
US5427739A (en) * 1992-08-27 1995-06-27 Schering-Plough Healthcare Products, Inc. Apparatus for performing immunoassays
US5302348A (en) 1992-12-10 1994-04-12 Itc Corporation Blood coagulation time test apparatus and method
US5578269A (en) 1993-06-11 1996-11-26 Ortho Diagnostic Systems Inc. Automated blood analysis system with an integral centrifuge
US5658801A (en) 1994-05-03 1997-08-19 Spectral Diagnostics Inc. Medical test kit
DE4420719C2 (en) 1994-06-15 1997-11-20 Henkel Kgaa Membrane-sealed tube with needle lock
ES2168389T3 (en) * 1994-09-08 2002-06-16 Lifescan Inc STRIP OF OPTICAL READING AND INCORPORATED PATTERN FOR THE DETECTION OF AN ANALYTE.
US5504011A (en) 1994-10-21 1996-04-02 International Technidyne Corporation Portable test apparatus and associated method of performing a blood coagulation test
US5728352A (en) * 1994-11-14 1998-03-17 Advanced Care Products Disposable electronic diagnostic instrument
US5882942A (en) 1995-02-15 1999-03-16 Wako Pure Chemical Industries, Ltd. Method for sampling feces
US5814275A (en) 1995-02-15 1998-09-29 Akzo Nobel N.V. Obstruction detector for a fluid flow line of a medical laboratory instrument
EP0920627B1 (en) 1996-06-07 2004-05-12 Immunivest Corporation Magnetic separation employing external and internal gradients
US5714123A (en) 1996-09-30 1998-02-03 Lifescan, Inc. Protective shield for a blood glucose strip
US5772966A (en) 1997-01-24 1998-06-30 Maracas; George N. Assay dispensing apparatus
US6342183B1 (en) 1997-02-14 2002-01-29 Escreen System for collecting and locally analyzing a fluid specimen
US5958349A (en) 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
US6002475A (en) * 1998-01-28 1999-12-14 Careside, Inc. Spectrophotometric analytical cartridge
US6271046B1 (en) * 1997-10-06 2001-08-07 Enterix, Inc. Apparatus and method for analyte detection
US6184040B1 (en) * 1998-02-12 2001-02-06 Polaroid Corporation Diagnostic assay system and method
US6391264B2 (en) * 1999-02-11 2002-05-21 Careside, Inc. Cartridge-based analytical instrument with rotor balance and cartridge lock/eject system
US6239445B1 (en) * 1999-03-01 2001-05-29 Bayer Corporation Optical inspection apparatus with removable inserts
US7011794B2 (en) * 2002-11-25 2006-03-14 Immunivest Corporation Upon a cartridge for containing a specimen sample for optical analysis

Also Published As

Publication number Publication date
EP1360471A1 (en) 2003-11-12
KR20030074816A (en) 2003-09-19
CN1491355A (en) 2004-04-21
EP1360471A4 (en) 2005-02-23
EP1360471B1 (en) 2006-09-20
DE60214827T2 (en) 2007-03-29
US7604777B2 (en) 2009-10-20
ATE340360T1 (en) 2006-10-15
US20050063863A1 (en) 2005-03-24
AU2002243968A2 (en) 2002-08-28
CA2434604C (en) 2010-09-28
US20020109838A1 (en) 2002-08-15
JP3766064B2 (en) 2006-04-12
IL156741A0 (en) 2004-02-08
US6861259B2 (en) 2005-03-01
DE60214827D1 (en) 2006-11-02
CA2708573C (en) 2012-05-01
JP2004526955A (en) 2004-09-02
BR0207095A (en) 2004-01-20
CA2434604A1 (en) 2002-08-22
AU2002243968B2 (en) 2007-01-25
WO2002065103A1 (en) 2002-08-22

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EEER Examination request
MKLA Lapsed

Effective date: 20210831

MKLA Lapsed

Effective date: 20200212