CA2711007A1 - G-csf analog compositions and methods - Google Patents
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- CA2711007A1 CA2711007A1 CA2711007A CA2711007A CA2711007A1 CA 2711007 A1 CA2711007 A1 CA 2711007A1 CA 2711007 A CA2711007 A CA 2711007A CA 2711007 A CA2711007 A CA 2711007A CA 2711007 A1 CA2711007 A1 CA 2711007A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Abstract
Provided herein are granulocyte colony stimulating factor ("G-CSF") analogs, compositions containing such analogs, and related compositions. In another aspect, provided herein are nucleic acids encoding the present analogs or related nucleic acids, related host cells and vectors. In yet another aspect, provided herein are computer programs and apparatuses for expressing the three dimensional structure of G-CSF and analogs thereof. In another aspect, provided herein are methods for rationally designing G-CSF analogs and related compositions. In yet another aspect, provided herein are methods for treatment using the present G-CSF analogs.
Claims (5)
1. A G-CSF molecule comprising amino acids 2-175 as set forth in SEQ ID
NO: 1, having the overall three-dimensional conformation as set forth in Figure 4, wherein the three-dimensional structure of the CD loop is altered from that represented in a computer program displaying the x-ray crystallographic coordinates as set forth in Figure 5.
NO: 1, having the overall three-dimensional conformation as set forth in Figure 4, wherein the three-dimensional structure of the CD loop is altered from that represented in a computer program displaying the x-ray crystallographic coordinates as set forth in Figure 5.
2. The G-CSF molecule of claim 1, additionally comprising an N-terminal methionine at position 1.
3. The G-CSF molecule of claim 1 or 2, wherein the overall three-dimensional conformation of the G-CSF molecule having an altered three-dimensional structure of the CD loop is:
a) an anti-parallel 4-alpha helical bundle with a left hand twist;
b) overall dimensions of 45 .ANG. x 30 x .ANG. x 24 .ANG.; and c) helix crossing angles ranging from -167.5° to 159.4°.
a) an anti-parallel 4-alpha helical bundle with a left hand twist;
b) overall dimensions of 45 .ANG. x 30 x .ANG. x 24 .ANG.; and c) helix crossing angles ranging from -167.5° to 159.4°.
4. A pharmaceutical composition comprising a G-CSF molecule according to claim 1, 2 or 3, and a pharmaceutically acceptable carrier.
5. The G-CSF molecule of claim 1 or 2, wherein said molecule is a hybrid molecule of G-CSF and another protein.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/010,099 | 1993-01-28 | ||
US08/010,099 US5581476A (en) | 1993-01-28 | 1993-01-28 | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
CA2381489A CA2381489C (en) | 1993-01-28 | 1994-01-25 | G-csf analog compositions and methods |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2381489A Division CA2381489C (en) | 1993-01-28 | 1994-01-25 | G-csf analog compositions and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2711007A1 true CA2711007A1 (en) | 1994-08-04 |
CA2711007C CA2711007C (en) | 2012-10-02 |
Family
ID=21743861
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002153896A Expired - Lifetime CA2153896C (en) | 1993-01-28 | 1994-01-25 | G-csf analog compositions and methods |
CA002239360A Expired - Lifetime CA2239360C (en) | 1993-01-28 | 1994-01-25 | G-csf analog compositions and methods |
CA2711007A Expired - Lifetime CA2711007C (en) | 1993-01-28 | 1994-01-25 | G-csf analog compositions and methods |
CA2381489A Expired - Lifetime CA2381489C (en) | 1993-01-28 | 1994-01-25 | G-csf analog compositions and methods |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002153896A Expired - Lifetime CA2153896C (en) | 1993-01-28 | 1994-01-25 | G-csf analog compositions and methods |
CA002239360A Expired - Lifetime CA2239360C (en) | 1993-01-28 | 1994-01-25 | G-csf analog compositions and methods |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2381489A Expired - Lifetime CA2381489C (en) | 1993-01-28 | 1994-01-25 | G-csf analog compositions and methods |
Country Status (22)
Country | Link |
---|---|
US (6) | US5581476A (en) |
EP (8) | EP0890640A3 (en) |
JP (7) | JPH08506018A (en) |
KR (2) | KR100375274B1 (en) |
CN (3) | CN1970571B (en) |
AT (2) | ATE195552T1 (en) |
AU (2) | AU697451B2 (en) |
CA (4) | CA2153896C (en) |
DE (1) | DE69425516T2 (en) |
DK (3) | DK1482046T3 (en) |
ES (3) | ES2150951T3 (en) |
FI (2) | FI120769B (en) |
GR (1) | GR3034745T3 (en) |
HK (2) | HK1009288A1 (en) |
IL (6) | IL108446A (en) |
LU (1) | LU92265I2 (en) |
LV (1) | LV12642B (en) |
NO (3) | NO952974L (en) |
NZ (5) | NZ332188A (en) |
PT (3) | PT612846E (en) |
WO (1) | WO1994017185A1 (en) |
ZA (1) | ZA94568B (en) |
Families Citing this family (140)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0401384B1 (en) * | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
US20030053982A1 (en) * | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
JP3708151B2 (en) * | 1994-12-15 | 2005-10-19 | 協和醗酵工業株式会社 | Quantification of PEGylated human granulocyte colony-stimulating factor |
US20030185792A1 (en) * | 1996-01-22 | 2003-10-02 | Curis, Inc. | Morphogen analogs of bone morphogenic proteins |
AU725295B2 (en) * | 1996-01-22 | 2000-10-12 | Brandeis University | Morphogen analogs and methods for producing them |
US5835382A (en) | 1996-04-26 | 1998-11-10 | The Scripps Research Institute | Small molecule mimetics of erythropoietin |
US6128582A (en) * | 1996-04-30 | 2000-10-03 | Vertex Pharmaceuticals Incorporated | Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them |
EP1881005B1 (en) * | 1997-07-14 | 2013-04-03 | Bolder Biotechnology, Inc. | Derivatives of G-CSF and related proteins |
US20080076706A1 (en) * | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US6017876A (en) | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
CN1061992C (en) * | 1997-11-19 | 2001-02-14 | 蒋永平 | Colony stimulating factor for recombination of human granulocytes and medicinal composition thereof |
TWI242563B (en) * | 1998-04-30 | 2005-11-01 | Tanox Inc | Monoclonal agonist antibodies which specifically bind to or interact with human G-CSF receptor |
CA2326755A1 (en) * | 1998-04-30 | 1999-11-04 | Tanox, Inc. | G-csf receptor agonist antibodies and screening method therefor |
US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
US6979442B1 (en) | 1998-08-17 | 2005-12-27 | Pfizer Inc. | Stabilized protein compositions |
US6420339B1 (en) | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
US6451346B1 (en) * | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
US6627186B1 (en) | 1999-01-06 | 2003-09-30 | Xencor | Nucleic acids and protein variants of hG-CSF with granulopoietic activity |
US7208473B2 (en) * | 1999-01-06 | 2007-04-24 | Xencor, Inc. | Nucleic acids and protein variants of hG-CSF with granulopoietic activity |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
ATE246202T1 (en) * | 1999-01-29 | 2003-08-15 | Hoffmann La Roche | GCSF CONJUGATES |
US6500418B1 (en) * | 1999-02-12 | 2002-12-31 | The Washington University | Stimulating neutrophil function to treat inflammatory bowel disease |
JP2000319298A (en) * | 1999-03-04 | 2000-11-21 | Seibutsu Bunshi Kogaku Kenkyusho:Kk | Crystal and structural coordinate of protein complex, and use of structural coordinate |
US20020164812A1 (en) * | 1999-04-06 | 2002-11-07 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
US7250305B2 (en) | 2001-07-30 | 2007-07-31 | Uab Research Foundation | Use of dye to distinguish salt and protein crystals under microcrystallization conditions |
US7247490B2 (en) | 1999-04-06 | 2007-07-24 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
US7244396B2 (en) | 1999-04-06 | 2007-07-17 | Uab Research Foundation | Method for preparation of microarrays for screening of crystal growth conditions |
DE60034033T2 (en) * | 1999-04-06 | 2007-12-06 | University of Alabama, Birmingham Research Foundation, Birmingham | DEVICE FOR SCREENING CRYSTALLIZATION CONDITIONS IN SOLUTIONS FOR CRYSTAL BREEDING |
US7214540B2 (en) * | 1999-04-06 | 2007-05-08 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
AU4835200A (en) * | 1999-05-10 | 2000-11-21 | Regents Of The University Of California, The | Methods and compositions for controlled polypeptide synthesis |
US6296673B1 (en) * | 1999-06-18 | 2001-10-02 | The Regents Of The University Of California | Methods and apparatus for performing array microcrystallizations |
US6630006B2 (en) * | 1999-06-18 | 2003-10-07 | The Regents Of The University Of California | Method for screening microcrystallizations for crystal formation |
US7058517B1 (en) | 1999-06-25 | 2006-06-06 | Genaissance Pharmaceuticals, Inc. | Methods for obtaining and using haplotype data |
CA2379388C (en) * | 1999-07-13 | 2012-05-29 | George N. Cox, Iii | Immunoglobulin fusion proteins |
US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
WO2001051510A2 (en) | 2000-01-10 | 2001-07-19 | Maxygen Holdings Ltd | G-csf conjugates |
US6646110B2 (en) * | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
US6831158B2 (en) * | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
GB0008563D0 (en) * | 2000-04-07 | 2000-05-24 | Cambridge Discovery Chemistry | Investigating different physical and/or chemical forms of materials |
ES2214240T3 (en) * | 2000-06-16 | 2004-09-16 | Vsi Holding A/S | CONTAINER WITH FOLDING SIDES. |
US6931326B1 (en) | 2000-06-26 | 2005-08-16 | Genaissance Pharmaceuticals, Inc. | Methods for obtaining and using haplotype data |
US7792645B2 (en) * | 2000-08-30 | 2010-09-07 | The Salk Institute For Biological Studies | Three-dimensional structure of chalcone isomerase and methods of use thereof |
US20040254351A1 (en) * | 2000-09-07 | 2004-12-16 | Beals John Michael | Hyperglycosylated polypeptides |
WO2002020766A2 (en) * | 2000-09-08 | 2002-03-14 | Massachusetts Institute Of Technology | G-csf analog compositions and methods |
WO2002036626A1 (en) * | 2000-11-02 | 2002-05-10 | Maxygen Aps | Single-chain multimeric polypeptides |
EP1419428A4 (en) * | 2001-03-12 | 2005-03-02 | Regents Board Of | Ensemble-based strategy for the design of protein pharmaceuticals |
DE10112825A1 (en) * | 2001-03-16 | 2002-10-02 | Fresenius Kabi De Gmbh | HESylation of active ingredients in aqueous solution |
US7670429B2 (en) | 2001-04-05 | 2010-03-02 | The California Institute Of Technology | High throughput screening of crystallization of materials |
US6998219B2 (en) * | 2001-06-27 | 2006-02-14 | University Of South Florida | Maskless photolithography for etching and deposition |
PL371781A1 (en) * | 2001-07-11 | 2005-06-27 | Maxygen Holdings, Ltd. | G-csf conjugates |
US20030104996A1 (en) * | 2001-08-30 | 2003-06-05 | Tiansheng Li | L-methionine as a stabilizer for NESP/EPO in HSA-free formulations |
US20040247562A1 (en) * | 2001-09-28 | 2004-12-09 | Sang Yup Lee | Diagnostic method for cancer characterized in the detection of the deletion of g-csf exon 3 |
DE10209821A1 (en) * | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Coupling of proteins to a modified polysaccharide |
DE10209822A1 (en) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Coupling of low molecular weight substances to a modified polysaccharide |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
WO2003100002A2 (en) * | 2002-05-23 | 2003-12-04 | Board Of Regents, The University Of Texas System | Predicting the significance of single nucleotide polymorphisms (snps) using ensemble-based structural energetics |
WO2004005898A1 (en) * | 2002-07-10 | 2004-01-15 | Uab Research Foundation | Method for distinguishing between biomolecule and non-biomolecule crystals |
ATE466085T1 (en) * | 2002-09-09 | 2010-05-15 | Hanall Pharmaceutical Co Ltd | PROTEASE-RESISTANT MODIFIED INTERFERON ALPHA POLYPEPTIDES |
CN1681844A (en) * | 2002-09-11 | 2005-10-12 | 弗雷泽纽斯卡比德国有限公司 | Hasylated polypeptides, especially hasylated erythropoietin |
DE10242076A1 (en) * | 2002-09-11 | 2004-03-25 | Fresenius Kabi Deutschland Gmbh | New covalently bonded conjugates of hydroxyalkyl starch with allergens, useful as modified allergens with depot effect for use in specific immunotherapy for combating allergies, e.g. hay fever |
WO2004032971A1 (en) * | 2002-10-08 | 2004-04-22 | Fresenius Kabi Deutschland Gmbh | Pharmaceutically active oligosaccharide conjugates |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
RS20050501A (en) * | 2002-12-26 | 2007-08-03 | Mountain View Pharmaceuticals Inc., | Polymer conjugates of cytokines,chemokines,growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
MXPA05006944A (en) * | 2002-12-26 | 2005-12-14 | Mountain View Pharmaceuticals | Polymer conjugates of interferon-beta. |
US7695723B2 (en) | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
US7785601B2 (en) | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
DE602004031681D1 (en) | 2003-07-21 | 2011-04-14 | Transgene Sa | Multifunctional cytokines |
WO2005014655A2 (en) * | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
WO2005014024A2 (en) * | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of a polymer and a protein linked by an oxime linking group |
US8338373B2 (en) * | 2003-10-24 | 2012-12-25 | Nora Therapeutics, Inc. | Method for reducing the risk of spontaneous abortion in a human female subject |
ES2405506T3 (en) | 2003-10-24 | 2013-05-31 | Nora Therapeutics, Inc. | A method to obtain useful data in the identification of a patient at risk of having a difficult pregnancy |
US20090226397A1 (en) * | 2003-10-24 | 2009-09-10 | Nora Therapeutics, Inc. | Compositions and methods for reducing the likelihood of implantation failure or miscarriage in recipients of artificial insemination |
US7220407B2 (en) * | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
US20060122784A1 (en) * | 2004-12-03 | 2006-06-08 | Ishikawa Muriel Y | System and method for augmenting a humoral immune response |
AU2004313245B2 (en) | 2003-12-30 | 2011-04-14 | Durect Corporation | Polymeric implants, preferably containing a mixture of PEG and PLG, for controlled release of active agents, preferably a GNRH |
EP1758608A2 (en) * | 2004-03-11 | 2007-03-07 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyethyl starch and erythropoietin |
EP2336192A1 (en) | 2004-03-11 | 2011-06-22 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
EP1774017B1 (en) | 2004-07-26 | 2013-05-15 | Pfenex Inc. | Process for improved protein expression by strain engineering |
US20060153799A1 (en) * | 2004-11-05 | 2006-07-13 | Northwestern University | Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders |
WO2006063300A2 (en) * | 2004-12-10 | 2006-06-15 | Genentech, Inc. | Crystal structure of hepatocyte growth factor activator complexed with kunitz domain inhibitor |
EP1828241A1 (en) | 2004-12-23 | 2007-09-05 | Laboratoires Serono S.A. | G-csf polypeptides and uses thereof |
CA2593682C (en) | 2005-01-10 | 2016-03-22 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
KR100657749B1 (en) * | 2005-04-13 | 2006-12-20 | 씨제이 주식회사 | Human Granulocyte-Colony Stimulating Factor Isoform and Composition thereof |
CA2607844C (en) * | 2005-06-01 | 2012-07-10 | Maxygen Holdings Ltd. | Pegylated g-csf polypeptides and methods of producing same |
KR100694994B1 (en) * | 2005-06-13 | 2007-03-14 | 씨제이 주식회사 | Human Granulocyte-Colony Stimulating Factor Isoforms |
KR100735784B1 (en) | 2005-07-20 | 2007-07-06 | 재단법인 목암생명공학연구소 | Mutant of granulocyte-colony stimulating factorG-CSF and chemically conjugated polypeptide thereof |
ES2420155T3 (en) * | 2005-08-15 | 2013-08-22 | Phares Drug Delivery Ag | Astaxanthin crystal forms |
WO2007024940A2 (en) * | 2005-08-22 | 2007-03-01 | Dana-Farber Cancer Institute, Inc. | Mitochondrial localization of muc1 |
US20070112804A1 (en) * | 2005-11-07 | 2007-05-17 | Desimas Bruce E | Systems and methods for generating automated software workflows for biological testing |
GB0605684D0 (en) * | 2006-03-21 | 2006-05-03 | Sicor Biotech Uab | Method For Purifying Granulocyte-Colony Stimulating Factor |
US8129345B2 (en) * | 2006-07-20 | 2012-03-06 | Dana-Farber Cancer Institute, Inc. | MUC1-IκB kinase complexes and their activities |
WO2008097840A2 (en) | 2007-02-02 | 2008-08-14 | Dana-Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of muc1 by hsf1 and stat3 |
WO2008097844A2 (en) * | 2007-02-02 | 2008-08-14 | Dana -Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins |
JP4375412B2 (en) * | 2007-02-19 | 2009-12-02 | 株式会社デンソー | Evaporator unit |
CA2685326A1 (en) | 2007-04-27 | 2008-11-06 | Dow Global Technologies Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
EA018715B1 (en) | 2007-07-03 | 2013-10-30 | Эмджен Инк. | Quantitative measurement of protein using inclusion body dry weight |
CN112480255A (en) | 2007-07-09 | 2021-03-12 | 健泰科生物技术公司 | Prevention of disulfide bond reduction during recombinant production of polypeptides |
EP2578677A1 (en) | 2007-08-09 | 2013-04-10 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
US8758761B2 (en) * | 2007-09-30 | 2014-06-24 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
US8570393B2 (en) * | 2007-11-30 | 2013-10-29 | Cognex Corporation | System and method for processing image data relative to a focus of attention within the overall image |
EP2070951A1 (en) * | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Method for producing a hydroxyalkyl starch derivatives with two linkers |
EP2070950A1 (en) * | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Hydroxyalkyl starch derivatives and process for their preparation |
MX2010008632A (en) | 2008-02-08 | 2010-08-30 | Ambrx Inc | Modified leptin polypeptides and their uses. |
WO2009103199A1 (en) | 2008-02-18 | 2009-08-27 | 江苏恒瑞医药股份有限公司 | A g-csf conjugate modified by water-soluble polymer |
JOP20190083A1 (en) | 2008-06-04 | 2017-06-16 | Amgen Inc | Fgf21 mutant fusion polypeptides and uses thereof |
AU2009274022B2 (en) | 2008-07-22 | 2016-06-02 | Menogenix, Inc. | Compositions and methods for treating symptoms associated with menopause, hormonal variations and arthritis |
NZ591235A (en) * | 2008-07-23 | 2012-07-27 | Ambrx Inc | Modified bovine g-csf polypeptides comprising non natural amino acid and their uses treating infections such as mastitis |
US9151289B2 (en) | 2008-08-21 | 2015-10-06 | Cummins Inc. | Fuel pump |
WO2010042747A2 (en) | 2008-10-10 | 2010-04-15 | Amgen Inc. | Fgf21 mutants and uses thereof |
US8524669B2 (en) | 2008-10-17 | 2013-09-03 | Dana-Farber Cancer Institute, Inc. | MUC-1 cytoplasmic domain peptides as inhibitors of cancer |
US9189670B2 (en) * | 2009-02-11 | 2015-11-17 | Cognex Corporation | System and method for capturing and detecting symbology features and parameters |
JP2012525847A (en) | 2009-05-05 | 2012-10-25 | アムジエン・インコーポレーテツド | FGF21 variants and uses thereof |
PE20120358A1 (en) | 2009-05-05 | 2012-04-26 | Amgen Inc | FGF21 MUTANTS AND USES OF THEM |
MX2011013903A (en) * | 2009-06-17 | 2012-05-08 | Amgen Inc | Chimeric fgf19 polypeptides and uses thereof. |
CA2782814A1 (en) | 2009-12-02 | 2011-06-09 | Amgen Inc. | Binding proteins that bind to human fgfr1c, human .beta.-klotho and both human fgfr1c and human .beta.-klotho |
UA109888C2 (en) * | 2009-12-07 | 2015-10-26 | ANTIBODY OR ANTIBODILITY ANTIBODY OR ITS BINDING TO THE β-CLOTE, FGF RECEPTORS AND THEIR COMPLEXES | |
CN107674121A (en) | 2009-12-21 | 2018-02-09 | Ambrx 公司 | Bovine somatotropin polypeptide and its purposes by modification |
CN104017063A (en) | 2009-12-21 | 2014-09-03 | Ambrx公司 | Modified porcine somatotropin polypeptides and their uses |
WO2011115819A2 (en) | 2010-03-15 | 2011-09-22 | Genus Oncology, Llc | Small molecule inhibitors of muc1 and methods of identifying the same |
DK2550366T3 (en) | 2010-03-23 | 2014-12-15 | Imba Inst Für Molekulare Biotechnologie Gmbh | Methods for identifying inhibitors of the type III secretion system |
US9517264B2 (en) | 2010-04-15 | 2016-12-13 | Amgen Inc. | Human FGF receptor and β-Klotho binding proteins |
TWI480288B (en) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | Formulations for bovine granulocyte colony stimulating factor and variants thereof |
EP3241558B1 (en) | 2010-09-28 | 2021-03-03 | Aegerion Pharmaceuticals, Inc. | Highly soluble leptins |
US8889630B2 (en) | 2011-12-23 | 2014-11-18 | Carlos Lopez | Method for hair regrowth using Granulocyte-Colony Stimulating Factor |
WO2014045126A2 (en) | 2012-09-18 | 2014-03-27 | Uti Limited Partnership | Treatment of pain by inhibition of usp5 de-ubiquitinase |
PE20152005A1 (en) | 2013-03-15 | 2016-01-29 | Bayer Healthcare Llc | GLA DOMAINS AS THERAPEUTIC AGENTS |
LT6161B (en) | 2013-09-27 | 2015-06-25 | Uab Profarma | Fused proteins of granulocyte colony-stimulating factor with other partners of growh factor, preferably with stem cell factor, and method of preparation thereof |
WO2015057724A1 (en) | 2013-10-14 | 2015-04-23 | Nora Therapeutics, Inc. | Use of g-csf for treating or preventing villitis of unknown etiology in a human female |
CN107949565A (en) * | 2015-06-11 | 2018-04-20 | 安姆生物制药有限责任公司 | Pegylated granulocyte colony-stimulating factor (GCSF) |
CA2998578A1 (en) * | 2015-10-19 | 2017-04-27 | Sandoz Ag | Improved coding sequence for human g-csf |
CN108384747A (en) * | 2018-03-05 | 2018-08-10 | 安徽省农业科学院园艺研究所 | Express the Chinese hamster ovary celI serum free suspension cultural method of Rabies virus antibody |
CA3151471A1 (en) * | 2019-10-08 | 2021-04-15 | Gesa VOLKERS | Modified extracellular domain of granulocyte colony-stimulating factor receptor (g-csfr) and cytokines binding same |
CA3159912A1 (en) | 2019-12-17 | 2021-06-24 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Novel g-csf mimics and their applications |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
WO1985000817A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
JPS6263335A (en) * | 1985-09-13 | 1987-03-20 | Fuji Photo Film Co Ltd | Processing method for chemical reaction information |
US4908773A (en) * | 1987-04-06 | 1990-03-13 | Genex Corporation | Computer designed stabilized proteins and method for producing same |
DK203187A (en) * | 1986-04-22 | 1987-10-23 | Immunex Corp | HUMAN G-CSF PROTEIN EXPRESSION |
WO1988001297A1 (en) * | 1986-08-11 | 1988-02-25 | Cetus Corporation | Expression of g-csf and muteins thereof |
US4704692A (en) * | 1986-09-02 | 1987-11-03 | Ladner Robert C | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
DK174044B1 (en) * | 1986-12-23 | 2002-05-06 | Kyowa Hakko Kogyo Kk | Polypeptide derived from human granulocyte colony stimulating factor, and method of preparation thereof, DNA encoding said polypeptide, recombinant plasmid containing said DNA, and microorganisms containing said recombinant plasmid ....... |
US4853871A (en) * | 1987-04-06 | 1989-08-01 | Genex Corporation | Computer-based method for designing stablized proteins |
GB2213821B (en) * | 1987-12-23 | 1992-01-02 | British Bio Technology | Synthetic human granulocyte colony stimulating factor gene |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
US5153265A (en) * | 1988-01-20 | 1992-10-06 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
CA1340810C (en) * | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
DE68918331T2 (en) * | 1988-06-03 | 1995-05-18 | Chugai Pharmaceutical Co Ltd | Human granulocyte crystalline colony stimulation factor and its production. |
US5025388A (en) * | 1988-08-26 | 1991-06-18 | Cramer Richard D Iii | Comparative molecular field analysis (CoMFA) |
US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5109119A (en) * | 1989-06-06 | 1992-04-28 | Schering Corporation | Crystalline r-h-gm-csf and method |
US5265030A (en) * | 1990-04-24 | 1993-11-23 | Scripps Clinic And Research Foundation | System and method for determining three-dimensional structures of proteins |
GB9107846D0 (en) * | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
DE4014750A1 (en) * | 1990-05-08 | 1991-11-14 | Boehringer Mannheim Gmbh | MUTEINE OF THE GRANULOCYTE-STIMULATING FACTOR (G-CSF) |
JP3249147B2 (en) | 1990-06-01 | 2002-01-21 | キリン−アムジエン・インコーポレーテツド | Oral preparation containing bioactive protein |
IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
CA2089553C (en) | 1990-08-29 | 2000-06-27 | Paul Schendel | Multidomain hematopoiesis stimulators |
US5124297A (en) | 1990-12-07 | 1992-06-23 | Amoco Corporation | Olefin polymerization and copolymerization catalyst |
DE4105480A1 (en) | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | IMPROVED ACTIVATION OF RECOMBINANT PROTEINS |
EP0576589A4 (en) * | 1991-03-18 | 1994-07-27 | Enzon Inc | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
US5157736A (en) * | 1991-04-19 | 1992-10-20 | International Business Machines Corporation | Apparatus and method for optical recognition of chemical graphics |
US5386507A (en) * | 1991-07-18 | 1995-01-31 | Teig; Steven L. | Computer graphics system for selectively modelling molecules and investigating the chemical and physical properties thereof |
WO1993005169A1 (en) * | 1991-08-30 | 1993-03-18 | Fred Hutchinson Cancer Research Center | Hybrid cytokines |
JP2638359B2 (en) * | 1991-11-26 | 1997-08-06 | 富士通株式会社 | Constraint condition generator for molecular dynamics method |
CA2137793C (en) * | 1992-06-09 | 2003-04-22 | Jayvardhan Pandit | Crystallization of m-csf |
US6153183A (en) | 1992-11-24 | 2000-11-28 | G. D. Searle & Company | Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production |
US6057133A (en) | 1992-11-24 | 2000-05-02 | G. D. Searle | Multivariant human IL-3 fusion proteins and their recombinant production |
US5738849A (en) | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
US5772992A (en) | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
EP0672145B1 (en) | 1992-11-24 | 2003-04-23 | G.D. Searle & Co. | Interleukin-3 (il-3) multiple mutation polypeptides |
US5424963A (en) * | 1992-11-25 | 1995-06-13 | Photon Research Associates, Inc. | Molecular dynamics simulation method and apparatus |
US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
US5635599A (en) | 1994-04-08 | 1997-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion proteins comprising circularly permuted ligands |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
EP0807181A1 (en) | 1995-02-03 | 1997-11-19 | G.D. Searle & Co. | NOVEL c-MPL LIGANDS |
US6017523A (en) | 1995-06-06 | 2000-01-25 | G.D. Searle & Co. | Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides |
WO1997012978A1 (en) | 1995-10-05 | 1997-04-10 | G.D. Searle & Co. | NOVEL c-mpl RECEPTOR AGONISTS |
US6066318A (en) | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
AU717733B2 (en) | 1995-10-05 | 2000-03-30 | G.D. Searle & Co. | Novel G-CSF receptor agonists |
US6100070A (en) | 1995-10-05 | 2000-08-08 | G. D. Searle & Co. | G-CSF receptor agonists |
CZ295518B6 (en) | 1995-10-05 | 2005-08-17 | G. D. Searle & Co. | Multi-functional hematopoietic receptor agonists |
WO1998017810A2 (en) | 1996-10-25 | 1998-04-30 | G.D. Searle & Co. | Multi-functional chimeric hematopoietic receptor agonists |
US5969105A (en) | 1996-10-25 | 1999-10-19 | Feng; Yiqing | Stem cell factor receptor agonists |
US6660257B1 (en) | 1996-10-25 | 2003-12-09 | Pharmacia Corporation | Circular permuteins of flt3 ligand |
EP0973900A1 (en) | 1997-04-11 | 2000-01-26 | G.D. Searle & Co. | flt3 LIGAND CHIMERIC PROTEINS |
EP1115854A1 (en) | 1998-09-25 | 2001-07-18 | G.D. Searle & Co. | Method of producing permuteins by scanning permutagenesis |
US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
EP2279755B1 (en) * | 2001-10-10 | 2014-02-26 | ratiopharm GmbH | Remodelling and glycoconjugation of Fibroblast Growth Factor (FGF) |
-
1993
- 1993-01-28 US US08/010,099 patent/US5581476A/en not_active Expired - Lifetime
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1994
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