CN100334049C - Lung cavity aeration liquid and its preparation method - Google Patents
Lung cavity aeration liquid and its preparation method Download PDFInfo
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- CN100334049C CN100334049C CNB031294618A CN03129461A CN100334049C CN 100334049 C CN100334049 C CN 100334049C CN B031294618 A CNB031294618 A CN B031294618A CN 03129461 A CN03129461 A CN 03129461A CN 100334049 C CN100334049 C CN 100334049C
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- perfluorodecalin
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- lung
- crude product
- heating
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Abstract
The present invention relates to ventilating liquid for the lung cavity. The present invention is characterized in that the ventilating liquid is perfluorodecalin, the boiling temperature is from 140 to 142 DEG C, and the specific gravity is above 1.9. The ventilating liquid of the present invention is an essential tool for liquid ventilation, lung compliance can be obviously improved, airway pressure can be reduced, the oxygenation state of bodies can be improved, the degree of blood oxygen saturation is increased, and the damage of the lung tissue is suppressed. The present invention has a plurality of advantages which mechanical ventilation does not have. The present invention is a main method for the medical clinic treatment and salvage of acute respiratory distress syndrome in the future and is a main method for the resistance of 'SARS' and the adjuvant therapy and the salvage of 'acute respiratory distress syndrome' at present. The present invention can lower the death rate.
Description
Technical field:
The present invention relates to the electrolysis process technical field of organic compound, specifically a kind of lung chamber aeration liquid and preparation method thereof.
Background technology:
According at present domestic clinical method to treatment and rescue acute respiratory distress syndrome, substantially be to use the not positive airway pressure of exhaling, divide mechanical ventilation modes such as side pulmonary ventilation and inversed ratio ventilation, this mode all can not directly be improved the physiological status of acute respiratory distress syndrome lung, in resisting " SARS ", need tracheostomize to carry out oxygenating to the patient who is in a bad way, not only cause the lung tissue damage easily, be difficult to reduce mortality ratio, and increase the infected danger of medical personnel.
Summary of the invention:
The object of the present invention is to provide a kind of lung chamber aeration liquid and preparation method thereof, this lung chamber aeration liquid can improve lung compliance, reduces airway pressure, improves the body oxygenation status, and does not need tracheostomize to carry out oxygenating, is not easy to cause the lung tissue damage.
To achieve these goals, technical scheme of the present invention is: lung chamber aeration liquid is characterized in that: described aeration liquid is a perfluorodecalin, and its boiling point is 140-142 ℃, and proportion is more than 1.9.
The preparation method of lung chamber aeration liquid, it is characterized in that: described preparation method may further comprise the steps, a, in 1 stage reactor, add potassium hydrogen fluoride, adopt 60-120 ℃ of heating to react, the nascent state fluorine of generation is directly put into the reaction of 2 grades of catalyticreactors and cobalt metal and is directly made the cobaltic fluoride heating and make temperature of reactor reach 150-350 ℃; B, get naphthalene and be dissolved in the vaporizer that fills naphthane, the weight ratio of naphthalene and naphthane is 1: 1-1: 10, add in the reactor with gaseous form after the vaporizer heating made solution evaporation, and reaction product is collected in the crude product container; Behind c, reinforced the finishing, through distilled water wash, anhydrous sodium sulfate drying gets thick product perfluorodecalin with gleanings in the crude product container, and reflux in the 20%KOH ethanolic soln till the solution pH value is greater than 12, after leaving standstill, is told lower floor, drying; D, carry out molecule rectifying purifying through the dried crude product perfluorodecalin of alkali cleaning with fractional column with above-mentioned, fractional column is made filler with recording wire, theoretical plate number 49-65,3.07 centimetres/plate of theoretical layer height, use the GC trace analysis in the rectifying, controlled temperature 140-142 ℃ collection is the perfluorodecalin elaboration; E, the perfluorodecalin elaboration filtered with Seitz filter after, be sub-packed in the special vial.
Lung of the present invention chamber aeration liquid is the main tool of liquid ventilation, can significantly improve lung compliance, reduce airway pressure, improve the body oxygenation status, improve blood oxygen saturation, suppress the lung tissue damage, has the incomparable advantage of mechanical ventilation, also being one of main means of clinical medicine treatment from now on and rescue acute respiratory distress syndrome, is one of main tool of current resistance " SARS " and energy assisting therapy and rescue " acute respiratory distress syndrome ", reduces mortality ratio.
Its main characteristic and index are: 1, have the chemical stability of height, the liquid water white transparency; 2, proportion is 1.9g/cm greater than water
3More than (25 ℃); 3, water insoluble and lipid is not absorbed by the body, and is nontoxic; 4, surface tension is little, less than 25 ℃ of 20mN/m; 5, to O
2And CO
2Solubleness be respectively 16 times and 2 times of water; 6, modest viscosity is 20 ℃ of 2.66mPa.s.
Embodiment:
The invention will be further described below in conjunction with drawings and Examples.
Lung of the present invention chamber aeration liquid is a kind of fluorocarbon, fluorocarbon of a great variety, and the synthesis technique method of purification has nothing in common with each other.Can produce different compounds according to different synthesis conditions, perfluorodecalin of the present invention, with regard to 140-142 ℃ of its boiling point, proportion is just different with the character of other perfluorocarbon compound more than 1.9.Aeration liquid of the present invention is a perfluorodecalin, and its boiling point is 140-142 ℃, and proportion is more than 1.9, and the molecular formula of perfluorodecalin is C in the enforcement
10F
18, molecular weight is 462.
The main raw material of lung of the present invention chamber aeration liquid is a perfluorodecalin, is to be that raw material carries out the complete airtight synthetic of perfluorodecalin and the rectifying purifying is obtained with naphthalene, naphthane and naphthalane, and chemical equation is as follows:
The preparation method of lung chamber aeration liquid, it is characterized in that: described preparation method may further comprise the steps, a, in 1 stage reactor, add potassium hydrogen fluoride, adopt 60-120 ℃ of heating to react, the nascent state fluorine of generation is directly put into the reaction of 2 grades of catalyticreactors and cobalt metal and is directly made the cobaltic fluoride heating and make temperature of reactor reach 150-350 ℃; B, get naphthalene and be dissolved in the vaporizer that fills naphthane, the weight ratio of naphthalene and naphthane is 1: 1-1: 10, add in the reactor with gaseous form after the vaporizer heating made solution evaporation, and reaction product is collected in the crude product container; Behind c, reinforced the finishing, through distilled water wash, anhydrous sodium sulfate drying gets thick product perfluorodecalin with gleanings in the crude product container, and reflux in the 20%KOH ethanolic soln till the solution pH value is greater than 12, after leaving standstill, is told lower floor, drying; D, carry out molecule rectifying purifying through the dried crude product perfluorodecalin of alkali cleaning with fractional column with above-mentioned, fractional column is made filler with recording wire, theoretical plate number 49-65,3.07 centimetres/plate of theoretical layer height, use the GC trace analysis in the rectifying, controlled temperature 140-142 ℃ collection is the perfluorodecalin elaboration; E, the perfluorodecalin elaboration filtered with Seitz filter after, be sub-packed in the vial.About heating in the step at 1,2 stage reactors, with gleanings through distilled water wash, anhydrous sodium sulfate drying and layering, drying, rectifying purifying, spectrum (GC) trace analysis all can be considered prior art with concrete operating process such as Seitz filter filtrations, are not described in detail at this.
The application of lung chamber aeration liquid in respiratory system is to determine according to its inherent physicochemical property.We control the time of fluorination reaction temperature, interpolation, the ratio that feeds intake etc. all can be influential to the productive rate of perfluorodecalin, is dissolved in the method for perhydronaphthalene with naphthalene, can avoid the reinforced difficulty of solid, and can make reaction process be difficult for producing overheated and cruelly towards phenomenon.Make that output, the quality of product are all very stable, its action principle is:
1, surface tension is little, because of the intermolecular bonding force of perfluorodecalin is low, so surface tension is little, is about 1/4th of water.So can play the effect of pulmonary surfactant, alveolar internal surface tension force and elastical retraction power are descended, thereby alveolar and lung compliance are significantly improved, prevent that alveolar from withering.
2, than great, density is high, can be evenly distributed in the alveolar in the heaviest dependence district of injury of lung, can " extrude the transudate in the impaired alveolar ", discharges CO
2, improve ventilatory.
3, improve ventilation, promote the oxygenate function of lung, because perfluorodecalin is 16 times of water to the solubleness of oxygen, the perfluorodecalin after the oxygenation can be carried enough oxygen to the pulmonary capillary bed.Can obviously improve blood oxygen saturation.Its main technical details is:
1. molecular formula: C
10F
18
2. molecular weight: 462
3. proportion:＞1.9g/cm
325 ℃
4. boiling point: 140-142
5. surface tension:＜20mN/m
6. viscosity: 2.66mPa.s
7. oxygen solubility: 〉=45 (25 ℃ ± 0.5 ℃ Vol%).
8. carbonic acid gas solubleness: 〉=150 (25 ℃ ± 0.5 ℃ Vol%).
9. chemical structure:
The application of lung chamber aeration liquid aspect breathing, the method that available trachea cannula instils are carried out or with the method that the atomizes perfusion of spraying.
Embodiment 1:
The preparation method of this lung chamber aeration liquid may further comprise the steps, a, in 1 stage reactor, add potassium hydrogen fluoride, adopt 70 ℃ of heating to react, the nascent state fluorine of generation is directly put into the reaction of 2 grades of catalyticreactors and cobalt metal and is directly made the cobaltic fluoride heating and make temperature of reactor reach 300 ℃; B, get naphthalene and be dissolved in the vaporizer that fills naphthane, the weight ratio of naphthalene and naphthane is 1: 2, adds in the reactor with gaseous form after the vaporizer heating is made solution evaporation, and reaction product is collected in the crude product container; Behind c, reinforced the finishing, with gleanings in the crude product container through distilled water wash, anhydrous sodium sulfate drying, get thick product perfluorodecalin, reflux in the 20%KOH ethanolic soln is 12.5 until the solution pH value, after leaving standstill, tell lower floor, be dried to moisture less than 1%; D, carry out molecule rectifying purifying through the dried crude product perfluorodecalin of alkali cleaning with fractional column with above-mentioned, fractional column is made filler with recording wire, theoretical plate number is 50,3.07 centimetres/plate of theoretical layer height, use the GC trace analysis in the rectifying, controlled temperature 140-142 ℃ collection is the perfluorodecalin elaboration; E, the perfluorodecalin elaboration filtered with Seitz filter after, be sub-packed in the special vial.
Embodiment 2:
The preparation method of this lung chamber aeration liquid may further comprise the steps, a, in 1 stage reactor, add potassium hydrogen fluoride, adopt 110 ℃ of heating to react, the nascent state fluorine of generation is directly put into the reaction of 2 grades of catalyticreactors and cobalt metal and is directly made the cobaltic fluoride heating and make temperature of reactor reach 180 ℃; B, get naphthalene and be dissolved in the vaporizer that fills naphthane, the weight ratio of naphthalene and naphthane is 1: 9, adds in the reactor with gaseous form after the vaporizer heating is made solution evaporation, and reaction product is collected in the crude product container; Behind c, reinforced the finishing, with gleanings in the crude product container through distilled water wash, anhydrous sodium sulfate drying, get thick product perfluorodecalin, reflux in the 20%KOH ethanolic soln is 12.5 until the solution pH value, after leaving standstill, tell lower floor, be dried to moisture less than 5%; D, carry out molecule rectifying purifying through the dried crude product perfluorodecalin of alkali cleaning with fractional column with above-mentioned, fractional column is made filler with recording wire, theoretical plate number is 60,3.07 centimetres/plate of theoretical layer height, use the GC trace analysis in the rectifying, controlled temperature 140-142 ℃ collection is the perfluorodecalin elaboration; E, the perfluorodecalin elaboration filtered with Seitz filter after, be sub-packed in the special vial.
Claims (1)
1, the preparation method of lung chamber aeration liquid, it is characterized in that: described preparation method may further comprise the steps, a, in 1 stage reactor, add potassium hydrogen fluoride, adopt 60-120 ℃ of heating to react, the nascent state fluorine of generation is directly put into the reaction of 2 grades of catalyticreactors and cobalt metal and is directly made the cobaltic fluoride heating and make temperature of reactor reach 150-350 ℃; B, get naphthalene and be dissolved in the vaporizer that fills naphthane, the weight ratio of naphthalene and naphthane is 1: 1-1: 10, add in the reactor with gaseous form after the vaporizer heating made solution evaporation, and reaction product is collected in the crude product container; Behind c, reinforced the finishing, through distilled water wash, anhydrous sodium sulfate drying gets thick product perfluorodecalin with gleanings in the crude product container, and reflux in the 20%KOH ethanolic soln till the solution pH value is greater than 12, after leaving standstill, is told lower floor, drying; D, carry out molecule rectifying purifying through the dried crude product perfluorodecalin of alkali cleaning with fractional column with above-mentioned, fractional column is made filler with recording wire, theoretical plate number 49-65,3.07 centimetres/plate of theoretical layer height, use the GC trace analysis in the rectifying, controlled temperature 140-142 ℃ collection is the perfluorodecalin elaboration; E, the perfluorodecalin elaboration filtered with Seitz filter after, be sub-packed in the special vial.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031294618A CN100334049C (en) | 2003-06-23 | 2003-06-23 | Lung cavity aeration liquid and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031294618A CN100334049C (en) | 2003-06-23 | 2003-06-23 | Lung cavity aeration liquid and its preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN1566404A CN1566404A (en) | 2005-01-19 |
| CN100334049C true CN100334049C (en) | 2007-08-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031294618A Expired - Fee Related CN100334049C (en) | 2003-06-23 | 2003-06-23 | Lung cavity aeration liquid and its preparation method |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110550996B (en) * | 2019-04-29 | 2022-04-05 | 苏州工业园区捷仕通医疗设备有限公司 | Preparation method of novel lung cavity ventilation liquid |
| CN111286749B (en) * | 2020-03-12 | 2021-07-30 | 石家庄保利农化工有限公司 | Method for preparing 1-fluoronaphthalene by electrochemical fluorination |
| CN113214042A (en) * | 2020-11-30 | 2021-08-06 | 苏州工业园区捷仕通医疗设备有限公司 | Heavy water for ophthalmic surgery |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5158536A (en) * | 1989-08-28 | 1992-10-27 | Biopulmonics, Inc. | Lung cancer hyperthermia via ultrasound and/or convection with perfiuorochemical liquids |
| CN1089252A (en) * | 1992-02-21 | 1994-07-13 | 法尔姆普尔有限公司 | The application of the method for purification of perfluoro-carbon and purified perfluoro-carbon |
-
2003
- 2003-06-23 CN CNB031294618A patent/CN100334049C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5158536A (en) * | 1989-08-28 | 1992-10-27 | Biopulmonics, Inc. | Lung cancer hyperthermia via ultrasound and/or convection with perfiuorochemical liquids |
| CN1089252A (en) * | 1992-02-21 | 1994-07-13 | 法尔姆普尔有限公司 | The application of the method for purification of perfluoro-carbon and purified perfluoro-carbon |
Non-Patent Citations (3)
| Title |
|---|
| Aldrich Catalog Handbook of Fine Chemicals 1181,Aldrich Chemical Company,Inc. 1989 * |
| 健康大鼠完全液体通气时血气、血压及心率的观察 张健鹏 等人，中国医药导刊，第4卷第3期 2002 * |
| 健康大鼠完全液体通气时血气、血压及心率的观察 张健鹏 等人，中国医药导刊，第4卷第3期 2002;Aldrich Catalog Handbook of Fine Chemicals 1181,Aldrich Chemical Company,Inc. 1989 * |
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Granted publication date: 20070829 Termination date: 20170623 |