CN100384371C - Performance testing device for superpolarized inertia gas nuclear magnetic resonance system - Google Patents

Performance testing device for superpolarized inertia gas nuclear magnetic resonance system Download PDF

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Publication number
CN100384371C
CN100384371C CNB2005101106540A CN200510110654A CN100384371C CN 100384371 C CN100384371 C CN 100384371C CN B2005101106540 A CNB2005101106540 A CN B2005101106540A CN 200510110654 A CN200510110654 A CN 200510110654A CN 100384371 C CN100384371 C CN 100384371C
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gas
container
magnetic resonance
nuclear magnetic
seal
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CN1803091A (en
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杨昆
任秋实
魏石刚
姚志萍
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Shanghai Jiaotong University
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Shanghai Jiaotong University
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Abstract

The present invention relates to a performance testing device for a hyperpolarization noble gas nuclear magnetic resonance system, and is used for the technical field of testing devices. The present invention comprises a container, layer surface thickness measuring members, image geometry distortion measurement members, a resolution measuring member and vacuum valves, wherein the container has the tightness for noble gas; the four layer surface thickness measuring members are respectively bonded on the four side inner walls of the container which has the tightness for the noble gas; the two image geometry distortion measurement members are respectively bonded on the two surfaces of orthogonal two layer surface thickness measuring members; the resolution measuring member is arranged in the middle of the container; the two vacuum valves are arranged on the opposite two side surfaces of the container. The present invention can exactly measure the signal-to-noise ratio, the scanning layer surface thickness, the scanning layer surface position, the image geometry distortion, the image resolution, etc. of the hyperpolarization noble gas nuclear magnetic resonance system.

Description

Performance testing device for superpolarized inertia gas nuclear magnetic resonance system
Technical field
What the present invention relates to is a kind of device that is used for technical field of measurement and test, particularly a kind of performance testing device for superpolarized inertia gas nuclear magnetic resonance system.
Background technology
Laser hyperpolarized noble gas nuclear magnetic resonance, NMR pulmonary disease diagnostic techniques adopts spin exchange optical pumping method.At first use circularly polarized laser pumping alkali metal atom (Cs, Rb, K, Na etc.) to improve alkali metal electronic spin polarizability.Alkali metal atom and noble gas molecular collision are transferred to radiationless, the avirulent noble gas molecule of human body spin angular momentaum (as the inertia isotope gas by hyperfine interaction 3He, 129Xe), can make the polarizability of noble gas improve 3 to 5 orders of magnitude.The hyperpolarized gas nmr imaging technique has a good application prospect, and can be widely applied to: pulmonary disease detects; Hollow organ imagings such as intestinal; Rich fatty tissue research; The cerebral function imaging of the rich fat structure of brain, cortex; Blood biochemical; The research of biomacromolecule (as protein) three-dimensional conformation; Heterogeneous nonhomogeneous system (porous, microparticle) imaging; Heterogeneous nonhomogeneous system inner fluid penetration study; Numerous areas such as conductor shielding material imaging.Parameters such as the signal to noise ratio of NMR system, scanning slice face thickness, scanning aspect position, image geometric distortion, image resolution ratio are most important concerning MRI (NMR (Nuclear Magnetic Resonance)-imaging) system.Before MRI equipment comes into operation, above-mentioned performance parameter is done detection accurately, so that correspondingly adjust running parameter, make the MRI system can be operated in optimum state.Simultaneously, MRI equipment because the fair wear and tear of hardware systems such as magnetic field, mechanical part can produce image error, need be adjusted system operational parameters, to obtain better diagnosing image effect after having used certain hour.
Through literature search to prior art, U.S. Patent Publication No. 5036280, the open date is: 1991.07.31, patent name is: the model that is used for NMR system.This patent readme is: the cylindrical tube of closed at both ends is packaged with various imaging measurement structures and is used for the liquid of imaging in it.Comprise the slice thickness measuring device that has pore structure of a V-arrangement, the number of imaging hole has been represented the thickness of scanning aspect.The position of scanning aspect is by determining by anglec of rotation arrangement, the interconnected adjacent video disc number that has groove structure.Resolution is also measured by the corresponding construction in being encapsulated in.At last, the position of first that repeatedly scans and last scanning aspect is measured by the edge on the inclined-plane that is placed on the sealed tube bottom.Air is imported in the sealed space bubble, thus not bubble existence freely in whole hermetically-sealed construction.Its weak point is: the hyperpolarized gas nuclear magnetic resonance equipment is all different in traditional H proton MRI equipment on hardware, software.Traditional NMR system is a signal source with the H proton in the biological tissue, and the hyperpolarized gas NMR system then is to be imaging object with polar noble gas.Special physics, chemical property that polarized gas is different from water have determined that the more design of needs is considered when test pole oxidizing gases nuclear magnetic resonance equipment.The prior art means are not considered the permeability that noble gas is special, do not consider the air-tightness requirement that noble gas is special; Do not consider the problem that the collision of polarized gas and material interface, self-rotary relaxation quicken; Do not consider that paramagnet is to influence of polarizability etc.Existing nuclear magnetic resonance, NMR test set can not be used for the Performance Detection of hyperpolarized gas nuclear magnetic resonance equipment.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art and defective, a kind of performance testing device for superpolarized inertia gas nuclear magnetic resonance system is provided, makes technical parameters such as its signal to noise ratio that can accurately measure the hyperpolarized gas NMR system, scanning slice face thickness, scanning aspect position, image geometric distortion, image resolution ratio.
The present invention is achieved by the following technical solutions, the present invention includes: the container that noble gas is had seal, slice thickness is measured member, image geometric distortion is measured member, the resolution measurement member, vacuum valve, four levels thickness measure member is bonded in respectively to have on four side inwalls of container of seal noble gas, two image geometric distortions are measured member and are bonded in respectively on two mutually perpendicular two surfaces of slice thicknesses measurement member, the resolution measurement member is located at the centre that noble gas is had the container of seal, the resolution measurement member is by support or directly be bonded in noble gas is had on the bottom surface of container inner wall of seal, and two vacuum valves are located to have on two relative sides of the container of seal noble gas.The container, slice thickness measurement member, the image geometric distortion that noble gas are had seal are measured member, resolution measurement member and vacuum valve and are all adopted diamagnetic material to make.
Described diamagnetic material is meant: glass, polymethyl methacrylate, polyolefin.
The described container that noble gas is had a seal is the cavity cube structure.
Described have the container of seal to noble gas, and its outer wall materials is for having the material of seal to polarized gas.
The described material that polarized gas is had a seal is meant: glass, polymethyl methacrylate.
Described have the container of seal and all built-in component surface that contact with polarized gas all scribble the coating material that can slow down the polarized gas self-rotary relaxation to noble gas.
The described coating material that slows down the polarized gas self-rotary relaxation is meant: paraffin, Teflon, deuterated polysiloxanes, deuterated silane polymer.
Described have the container of seal to noble gas, and the material of its sealing member is a polyolefin.
Described polyolefin is meant: the mixture of polyethylene, polypropylene or above-mentioned substance.
Described slice thickness measurement member is made up of four triangular plates, and gapped between the triangular plate, the gap is 1mm or 2mm.
Described triangular plate is an isosceles right triangle, and the right-angle side of two triangular plates of the right-angle side of any one triangular plate and next door is adjacent.
Described image geometric distortion measurement member is made up of a liner plate, some semi-open rectangular cavity structures, some solid cube structures, and solid cube structure intersperses among in the middle of the semi-open rectangular cavity structure, does the contrast purposes.Semi-open rectangular cavity structure is closely aligned according to the matrix queueing discipline with solid cube structure is in the same place, and semi-open rectangular cavity structure and solid cube structure are bonded in the surface of liner plate.
Described semi-open rectangular cavity structure and solid cube structure, its profile, size are identical.
Described semi-open rectangular cavity structure is bonded by three blocks of plates.
Described matrix queueing discipline, be meant four semi-open rectangular cavity structures or the equilateral alignment of solid cube structure that semi-open rectangular cavity structure or solid cube structure all are adjacent, their outer wall is closely linked, and forms the square matrix of two-dimensional arrangements in the surface plane of liner plate.
Described resolution measurement member is bonded by two cubes that have different apertures through hole, through hole respectively along mutually perpendicular axially, for example, the through hole on cube is along X-direction, through hole on another cube can obtain the two-dimensional detection imaging along Y direction.
Described through hole is circular or square, preferably square.Because when punch operation, the easier control aperture precision of square opening.
Described through hole is equidistantly arranged, and when through hole was circular, its spacing equated with the aperture of through hole; When through hole was square, its spacing equated with the length of side of through hole.
Described vacuum valve, its material be polyolefin, as the mixture of polyethylene, polypropylene or above-mentioned substance.
Work process of the present invention and operation principle are: before carrying out NMR (Nuclear Magnetic Resonance)-imaging, with roughing pump whole device is carried out emptying earlier, so that oxygen, steam and other paramagnetic Impurity removal are fallen.High-pure gas such as nitrogen are filled in the container with the remaining foreign material of further removing.Last carry out emptying process again in case with oxygen concentration lower, further reduce the contact induction depolarization effect of hyperpolarized gas.Hyperpolarized noble gas charged into by vacuum valve noble gas is had in the container of seal, hyperpolarized noble gas permeates into to have in the cavity, gap of the container of seal and on-board components thereof noble gas.Carry out NMR (Nuclear Magnetic Resonance)-imaging to measuring member, obtain comparing with the original geometric figure of measurement member behind the MRI image.1, the resolution measurement member is carried out the MRI fault imaging, filled hyperpolarized noble gas in the through hole in the different apertures of perforation, the MRI image of resulting hyperpolarized noble gas has embodied shape, the aperture of the through hole in the different apertures that connect.Along the through hole in different apertures axial tangentially carry out tomoscan, in a scanning aspect, can obtain the MRI image of the through hole in different apertures simultaneously.The through hole of the minimum-value aperture that can offer an explanation has been expressed the resolution of hyperpolarized gas NMR system; 2, slice thickness is measured member and carry out the MRI fault imaging, filled hyperpolarized noble gas in the gap between the triangular plate, thereby can obtain the nuclear magnetic resonance image in gap, on nuclear magnetic resonance image, show as two pairs of line segments in correspondence with each other.Can record slice thickness, aspect position etc. according to data such as the image length that obtains, spacings; 3, image geometric distortion is measured member and carry out the MRI fault imaging, tomoscan plane and liner plate plane parallel.Fill hyperpolarized noble gas in the semi-open rectangular cavity structure, thereby obtained semi-open rectangular cavity structure by NMR image.The outer wall of semi-open rectangular cavity structure and solid cube structure then show as the disappearance of signal.Under the system operational parameters optimal cases, the figure that obtains should be regularly arranged square, and semi-open rectangular cavity structure outer wall image links up and should be the straight line of (vertically) parallel to each other together.According to the deformation of square-shaped image, the data such as bending of string diagram picture, can record the geometric distortion of NMR system.
The present invention has mainly considered following critical problem: 1) take into full account the requirement of container air-tightness; 2) the nuclear spin relaxation time of gaseous state hyperpolarized noble gas is very short, has taken into full account the collision of polarized gas and material interface, the problem that self-rotary relaxation quickens; 3) any paramagnetic medium all can quicken relaxation, adopts diamagnetic material to make all members; 4) take into full account the requirement that as far as possible keeps the polarized gas polarizability, coat the material that slows down the polarized gas self-rotary relaxation in all component surface that contact with polarized gas; 5) can accurately measure the technical parameters such as signal to noise ratio, scanning tomography thickness, scanning aspect position, image geometric distortion, image resolution ratio of hyperpolarized gas NMR system.
The invention has the beneficial effects as follows: taken into full account special physics, the chemical property of polarized gas.This installs all parts and is made by the diamagnetism dielectric material.All surfaces that contact with hyperpolarized gas all scribble the coating material that can slow down the polarized gas self-rotary relaxation.To noble gas have the container seal of seal and vacuum valve with polyolefin for example the mixture of polyethylene, polypropylene or above-mentioned substance make.Along the through-hole structure design in the two-dimentional different apertures of vertical axial, can carry out the MRI resolution measurement of two dimension.Employing square opening structure makes the processing in hole and measures more accurate.Adopt the interstitial structure of square crossing to measure scanning aspect parameter.Adopt regularly arranged semi-open rectangular cavity structure measurement geometric distortion, and design there is the contrast module.The invention solves nuclear magnetic resonance, NMR test model in the past and be not suitable for the problem of polarized gas NMR system test, improved the measuring accuracy of hyperpolarized gas NMR system.The present invention is simple in structure, has higher certainty of measurement, can carry out measuring multiple parameters simultaneously, the performance of full test hyperpolarized gas MRI system.Filled up blank in hyperpolarized gas NMR system performance measurement field.
Description of drawings
Fig. 1 is a structural representation of the present invention.
Fig. 2 is for having the container sketch map of seal to noble gas.
Fig. 3 is a resolution measurement member sketch map.
Fig. 4 measures the member sketch map for slice thickness.
Fig. 5 measures the member sketch map for image geometric distortion.
The specific embodiment
As Fig. 1,2,3,4, shown in 5, the present invention includes: the container 1 that noble gas is had seal, slice thickness is measured member 2, image geometric distortion is measured member 3, resolution measurement member 4, vacuum valve 5, four levels thickness measure member 2 is bonded in respectively to have on four side inwalls of container 1 of seal noble gas, two image geometric distortions are measured member 3 and are bonded in respectively on two slice thicknesses measurement member 2 mutually perpendicular two surfaces, resolution measurement member 4 is located at the centre that noble gas is had the container 1 of seal, resolution measurement member 4 is by support or directly be bonded in noble gas is had on the bottom surface of container 1 inwall of seal, two vacuum valves 5 are located to have on two relative sides of the container 1 of seal noble gas, noble gas is had the container 1 of seal, slice thickness is measured member 2, image geometric distortion is measured member 3, resolution measurement member 4 and vacuum valve 5 all adopt diamagnetic material to make.
Described diamagnetic material is meant: glass, polymethyl methacrylate, polyolefin.
The described container 1 that noble gas is had seal is the cavity cube structure.
Described have the container 1 of seal to noble gas, and its outer wall materials is for having the material of seal to polarized gas.
The described material that polarized gas is had a seal is meant: glass, polymethyl methacrylate.
Described have the container 1 of seal and all built-in component surface that contact with polarized gas all scribble the coating material that can slow down the polarized gas self-rotary relaxation to noble gas.
The described coating material that slows down the polarized gas self-rotary relaxation is meant: paraffin, Teflon, deuterated polysiloxanes, deuterated silane polymer.
Described have the container 1 of seal to noble gas, and the material of its sealing member is a polyolefin.
Described polyolefin is meant: the mixture of polyethylene, polypropylene or above-mentioned substance.
Described slice thickness is measured member 2 and is made up of four triangular plates 9, and gapped 8 between the triangular plate 9, gap 8 is 1mm or 2mm.
Described triangular plate 9 is an isosceles right triangle, and the right-angle side of two triangular plates 9 of the right-angle side of any one triangular plate 9 and next door is adjacent.
Described image geometric distortion measurement member 3 is made up of a liner plate 10, some semi-open rectangular cavity structures 11, some solid cube structures 12, and solid cube structure 12 intersperses among in the middle of the semi-open rectangular cavity structure 11, does the contrast purposes.Semi-open rectangular cavity structure 11 is closely aligned according to the matrix queueing discipline with solid cube structure 12 is in the same place, and semi-open rectangular cavity structure 11 and solid cube structure 12 are bonded in the surface of liner plate 10.
Described semi-open rectangular cavity structure 11 and solid cube structure 12, its profile, size are identical.
Described semi-open rectangular cavity structure 11 is bonded by three blocks of plates.
Described matrix queueing discipline, be meant four semi-open rectangular cavity structures 11 or the 12 equilateral alignment of solid cube structure that semi-open rectangular cavity structure 11 or solid cube structure 12 all are adjacent, their outer wall is closely linked, and forms the square matrix of two-dimensional arrangements in the surface plane of liner plate 10.
Described resolution measurement member 4 is bonded by two cubes 6 that have the through hole 7 in different apertures, through hole 7 respectively along mutually perpendicular axially, for example, the through hole 7 on cube 6 is along X-direction, through hole 7 on another cube 6 can obtain the two-dimensional detection imaging along Y direction.
Described through hole 7 is circular or square, preferably square.Because when punch operation, the easier control aperture precision of square opening.
Described through hole 7 is equidistantly arranged, and when through hole 7 was circular, its spacing equated with the aperture of through hole 7; When through hole 7 was square, its spacing equated with the length of side of through hole 7.
Described vacuum valve 5, its material are polyolefin, as the mixture of polyethylene, polypropylene or above-mentioned substance.

Claims (10)

1. performance testing device for superpolarized inertia gas nuclear magnetic resonance system, comprise: the container (1) that noble gas is had seal, slice thickness is measured member (2), resolution measurement member (4), vacuum valve (5), it is characterized in that, also comprise: image geometric distortion is measured member (3), described image geometric distortion is measured member (3) by a liner plate (10), some semi-open rectangular cavity structures (11), some solid cube structures (12) are formed, solid cube structure (12) intersperses among in the middle of the semi-open rectangular cavity structure (11), semi-open rectangular cavity structure (11) and solid cube structure (12) are closely aligned together according to the matrix queueing discipline, and semi-open rectangular cavity structure (11) and solid cube structure (12) are bonded in the surface of liner plate (10);
Four levels thickness measure member (2) is bonded in respectively to have on four side inwalls of container (1) of seal noble gas, two image geometric distortions are measured member (3) and are bonded in respectively on two mutually perpendicular two surfaces of slice thicknesses measurement member (2), resolution measurement member (4) is located at the centre that noble gas is had the container (1) of seal, resolution measurement member (4) is by support or directly be bonded in noble gas is had on the bottom surface of container (1) inwall of seal, two vacuum valves (5) are located to have on two relative sides of the container (1) of seal noble gas, noble gas is had the container (1) of seal, slice thickness is measured member (2), image geometric distortion is measured member (3), resolution measurement member (4) and vacuum valve (5) all adopt diamagnetic material to make.
2. performance testing device for superpolarized inertia gas nuclear magnetic resonance system according to claim 1 is characterized in that, described diamagnetic material is meant: glass, polymethyl methacrylate, polyolefin.
3. performance testing device for superpolarized inertia gas nuclear magnetic resonance system according to claim 1 is characterized in that, described have the container (1) of seal to noble gas, and its outer wall materials is for having the material of seal to polarized gas.
4. performance testing device for superpolarized inertia gas nuclear magnetic resonance system according to claim 3 is characterized in that, the described material that polarized gas is had a seal is meant: glass, polymethyl methacrylate.
5. performance testing device for superpolarized inertia gas nuclear magnetic resonance system according to claim 1, it is characterized in that described have the container (1) of seal and all built-in component surface that contact with polarized gas all scribble the coating material that can slow down the polarized gas self-rotary relaxation to noble gas.
6. performance testing device for superpolarized inertia gas nuclear magnetic resonance system according to claim 5, it is characterized in that, the described coating material that slows down the polarized gas self-rotary relaxation is meant: paraffin, Teflon, deuterated polysiloxanes, deuterated silane polymer.
7. performance testing device for superpolarized inertia gas nuclear magnetic resonance system according to claim 1, it is characterized in that, described slice thickness measurement member (2) is made up of four triangular plates (9), and between the triangular plate (9) gapped (8), gap (8) are 1mm or 2mm.
8. performance testing device for superpolarized inertia gas nuclear magnetic resonance system according to claim 7, it is characterized in that, described triangular plate (9) is an isosceles right triangle, and the right-angle side of two triangular plates in right-angle side of any one triangular plate (9) and next door (9) is adjacent.
9. performance testing device for superpolarized inertia gas nuclear magnetic resonance system according to claim 1, it is characterized in that, described matrix queueing discipline, be meant four semi-open rectangular cavity structures (11) or the equilateral alignment of solid cube structure (12) that semi-open rectangular cavity structure (11) or solid cube structure (12) all are adjacent, their outer wall is closely linked, and forms the square matrix of two-dimensional arrangements in the surface plane of liner plate (10).
10. performance testing device for superpolarized inertia gas nuclear magnetic resonance system according to claim 1, it is characterized in that, described resolution measurement member (4) is bonded by two cubes (6) that have the through hole (7) in different apertures, and through hole (7) is respectively along mutually perpendicular axial.
CNB2005101106540A 2005-11-24 2005-11-24 Performance testing device for superpolarized inertia gas nuclear magnetic resonance system Expired - Fee Related CN100384371C (en)

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CN102023288B (en) * 2010-11-22 2013-02-20 中联煤层气国家工程研究中心有限责任公司 Test device and method for testing nuclear magnetic resonance equipment with same
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