CN100391404C - 微刀片阵列的冲击式敷贴器 - Google Patents
微刀片阵列的冲击式敷贴器 Download PDFInfo
- Publication number
- CN100391404C CN100391404C CNB018204627A CN01820462A CN100391404C CN 100391404 C CN100391404 C CN 100391404C CN B018204627 A CNB018204627 A CN B018204627A CN 01820462 A CN01820462 A CN 01820462A CN 100391404 C CN100391404 C CN 100391404C
- Authority
- CN
- China
- Prior art keywords
- piston
- main body
- impact
- cover piece
- spring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000007246 mechanism Effects 0.000 claims description 19
- 238000010304 firing Methods 0.000 claims description 15
- 230000033001 locomotion Effects 0.000 claims description 5
- 230000003116 impacting effect Effects 0.000 claims description 4
- 210000000434 stratum corneum Anatomy 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 53
- 238000009527 percussion Methods 0.000 description 13
- 238000005070 sampling Methods 0.000 description 13
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 210000004247 hand Anatomy 0.000 description 6
- 230000006835 compression Effects 0.000 description 5
- 238000007906 compression Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 210000003141 lower extremity Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000004899 motility Effects 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000005452 bending Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000004905 finger nail Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
- A61B5/1405—Devices for taking blood samples
- A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150274—Manufacture or production processes or steps for blood sampling devices
- A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150801—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming
- A61B5/150824—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15103—Piercing procedure
- A61B5/15107—Piercing being assisted by a triggering mechanism
- A61B5/15113—Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
- A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15142—Devices intended for single use, i.e. disposable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
- A61B5/15188—Constructional features of reusable driving devices
- A61B5/1519—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for propelling the piercing unit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
- A61B5/15188—Constructional features of reusable driving devices
- A61B5/15192—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing
- A61B5/15194—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing fully automatically retracted, i.e. the retraction does not require a deliberate action by the user, e.g. by terminating the contact with the patient's skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Abstract
一种敷贴器装置(10)设置用于施加具有微凸起阵列(90)的贴(44)到角质层上。敷贴器装置(10)包括装置主体(12)和在装置主体(12)内可运动的活塞。盖件(16)设置在装置主体(12)上以便用微凸起阵列(44,90)冲击角质层。装置(10)可以由手上无力并缺乏灵活性击发其他类型敷贴器装置的患者使用。
Description
技术领域
本发明涉及一种用于通过冲击将刺入构件施加到皮肤角质层的装置和方法,并且本发明尤其涉及一种使用例如微凸起阵列的刺入构件重复刺入角质层以便通过皮肤输送或采样介质。
背景技术
随着可以在市场上得到大量和纯态的医用肽和蛋白质,对于肽和蛋白质通过皮肤输送到人体的兴趣日益增长。通过皮肤输送肽和蛋白质面临很大的问题。在许多场合,由于多肽大尺寸和分子重量,通过皮肤输送多肽的速度和流量不足以产生所需治疗效果。另外,多肽和蛋白质在到达目标细胞之前容易在刺入皮肤期间和之后降级。同样,许多低分子重量的化合物的被动通过皮肤的流量过于受到限制从而不能达到治疗效果。
一种增加通过皮肤输送介质的方法倚靠使用皮肤刺入增强器对于皮肤预处理或与有益介质一起输送。刺入增强器物质在施加到输送介质的身体表面时例如通过增加身体表面的选择刺入性和/或刺入性来增强介质的通过皮肤的流量和/或降低介质的降级。
增加介质流量的另一方法涉及在身体表面上施加电流并称之为“电迁移”。“电迁移”通常指的是有例如药物或药引的有益介质通过例如皮肤、黏膜、指甲和类似物。通过施加电位引起或增强介质输送,该电位由施加电流产生并用于输送或增强介质的输送。电迁移输送增强介质的输送并降低通过皮肤输送期间的多肽的降级。
已经有许多尝试以便机械地刺入或穿过皮肤从而增加通过皮肤的流量。参考例如授予Godshall等人的US 5,879,326,授予Ganderton等人的US 5,814,097,授予Gross等人的US 5,279,544,授予Lee等人的US 5,250,023,授予Gerstel等人的US 3,964,482,授予Kravitz等人的Reissue25,637,和PCT公开号W O96/37155,WO96/37256,WO 96/17648,WO 97/03718,WO 98/11937,WO 98/00193,WO97/48440,WO 97/48441,WO 97/48442,WO 98/00193,WO 99/64580,WO9828037,WO 98/29298,WO 98/29365。这些装置使用不同形状和尺寸的穿刺元件刺透皮肤的最外层(即,角质层)。这些参考文件所披露的刺入元件通常从例如垫或片的薄的平构件垂直延伸。某些这种装置的刺入元件极小,有些具有只有大约25~400μm的尺寸(微刀片长度和宽度)以及大约5~500μm的微刀片厚度。其他刺入元件是具有大约10μm或更小直径以及大约50~100μm长度的中空针。这些小的角质层穿刺/切割元件意欲在角质层内形成相应小的微切口/微裂口以便增强介质通过皮肤通过其中。在许多场合,角质层内的微切口/微裂口具有小于150μm的长度和显著小于其长度的宽度。
皮肤刺入装置用来以多个微凸起刺入皮肤的最外层(角质层)以便形成通路,通过该通路引入(输送)例如药物的介质或抽出例如身体分析物的介质(采样)。穿孔皮肤对于通过皮肤持续输送介质或采样提供改善的流量。
当微凸起阵列用来改善通过皮肤输送或采样介质时,需要连续、完整和可重复的刺入。用手施加具有从其接触皮肤侧突出的微凸起的皮肤贴经常导致在该贴的长度和宽度上穿刺深度的显著变化。另外,由于使用者施加阵列的方式,用手施加导致施加之间的穿刺深度的很大变化。因此,希望使用自动装置以连续和可重复的方式将微凸起阵列施加到角质层上,角质层不仅在微凸起阵列的长度和宽度上进行穿刺而且在施加一个微凸起到另一个穿刺。
在WO 99/26539和WO 97/42886中描述用于输送用于采样体液(例如血液)的小刀的已知弹簧加载敷贴器装置。然而,这些装置由于其需要在施加之前两手击发敷贴器装置所以难以使用。特别是,已知弹簧加载的小刀敷贴器需要该装置的的两个部段拉开以便击发或需要该装置的一部分相对于该装置的另一部分扭转以便击发。在两种运动中,需要两手击发操作。许多使用这些装置的患者不具有力量或手的灵活性击发这些已知的敷贴器装置。
因此,需要提供一种用于皮肤刺入构件的弹簧加载敷贴器,它可通过使用者单手操作并需要最小的手击发力。
发明内容
本发明涉及一种使用冲击施加刺入构件到角质层的敷贴器。该刺入构件可以是用来改善介质通过皮肤输送的微凸起阵列。该敷贴器包括允许单手击发操作的击发机构。由于该击发力可由使用者手臂来施加,该击发机构需要最小的手的力量和灵活性。
按照本发明的一个方面,提供了一种用于冲击刺入构件压靠角质层的装置,其包括具有第一和第二端的主体;所述第一端适于容纳该刺入构件;可滑动地配置在输送主体内以便冲击该刺入构件压靠该角质层的活塞;适于提供冲击力到该活塞上并偏置所述活塞到所述主体的所述第一端之外的冲击弹簧;其中所述冲击弹簧在所述活塞进一步位于所述主体内时聚集能量,锁栓机构,所述锁栓机构适于在所述活塞已经充分位于所述主体内时使用单手可松开地将所述活塞与所述主体接合;以及用于脱开所述锁栓机构的松开机构,由此所述冲击弹簧冲击所述活塞压靠该刺入构件,强迫该刺入构件进入所述角质层。
在本发明的上述装置中,还包括所述主体上的柔性指部和所述活
塞上的止档,其中所述柔性指部和所述止档包括所述相互接合的锁栓构件。
按照本发明的另一方面,用于冲击微刀片阵列压靠角质层的装置包括装置主体,安装在该装置主体内的活塞,该活塞具有微刀片阵列施加表面,位于该装置主体和该活塞之间以便用该微刀片冲击角质层的冲击活塞,可运动地安装在该装置主体上的盖件,作用在该装置主体和该盖件之间的压紧弹簧,用于通过使用单手将该装置主体和活塞锁定在击发位置的锁栓机构,以及用于从该击发位置松开该活塞以便当压紧弹簧压缩时用微刀片阵列冲击角质层的活塞松开装置。
在本发明的上述装置中,该活塞松开装置包括松开指部,该锁栓机构包括柔性指部和止档。
附图说明
本发明现在将壳体附图中所示的优选实施例进行更详细描述,其中相同元件具有相同的参考标号,并且附图中:
图1是在击发之前处于初始构形的敷贴器装置的侧截面图;
图2是在击发位置上图1敷贴器装置的侧截面图,其中贴保持件连接在敷贴器上;
图3是在活塞已经松开施加该贴之后带有图2贴保持件的图1敷贴器装置的侧截面图;
图4是图1敷贴器装置的分解透视图;
图5是敷贴器装置的可选择实施例的透视图;
图6是图5敷贴器装置的局部剖视的侧视图;以及
图7是微凸起阵列实例一部分的透视图。
具体实施方式
本发明的敷贴器装置用来与通过皮肤输送治疗介质(例如药物)或通过皮肤采样身体分析物(例如葡萄糖)相结合可重复地将微凸起阵列施加到角质层上。尽管所述敷贴器装置10使用某种连续的微凸起阵列,应该理解该敷贴器装置同样可使用其他类型的角质层微刺入构件。该敷贴器装置可通过手上无力或灵活性使用其他类型弹簧加载敷贴器的患者使用。另外,该敷贴器装置可用单手操作来击发和松开,这提供一定的优点,例如使得患者在患者自己手臂的部位上通过药物输送微凸起阵列局部治疗。
现参考图1,其中表示包括装置主体12和可在装置主体内运动的活塞14的敷贴器装置10。盖件16设置在装置主体12上以便致动敷贴器用微凸起阵列(在图1中未示出)冲击角质层。冲击弹簧20围绕活塞14的杆22定位并相对于装置主体12向下偏置活塞。活塞14具有下表面18,该表面是大致平的并略微凸起或构造成一身体表面(即特定皮肤位置)。活塞14的下表面18造成包括微凸起阵列的微凸起阵列或皮肤贴冲击并穿刺角质层。
图1表示活塞14在未击发位置,而图2表示活塞14在击发位置。当敷贴器装置10击发时,活塞14向上压在装置主体12的内部并通过锁定机构锁定就位。锁定机构包括在杆22上的卡扣26和位于装置主体12上并具有相应锁栓30的柔性指部28。
当活塞14向装置主体12运动压缩冲击弹簧20时,卡扣26柔曲指部28并卡扣在柔性指部28的相应锁栓30之上。通过将活塞击发和锁定在击发位置的简单压缩运动实现击发步骤。此击发步骤便于只用单手在使用者手和另一表面(例如桌面)之间压缩敷贴器装置10来实现。
图2表示敷贴器装置10,其中活塞14处于击发构形。如图2所示,在击发位置,卡扣26和活塞14上的锁栓20以及装置主体12可松开地接合以便防止活塞在装置主体内的向下运动。
图2同样表示安装在装置主体12上的贴保持件34。保持件34具有环形形状,其第一端40构造成与装置主体12接合。保持件34的第二端设置角质层接触表面。贴44安装在保持件34的第一和第二端40、42之间。贴44悬置在保持件34内。尽管贴44在保持件34内的安装方式以及贴44在保持件34内的安装位置可以变化(例如,贴44可以靠近保持件34的第二端42定位),最好将贴44从端40、42凹入一段距离安装(图1所示)以便避免该贴的微凸起与其他物体(例如使用者的手指)无意的接触。
按照实例,贴44通过贴底部材料的易断部分连接到粘接到击发环件34上的贴材料的环形件上。贴44通过活塞14的向下力从击发环件34上分开。作为选择,贴可松开地连接到活塞14和定位在活塞之下的皮肤上。
敷贴器装置10可使用通常包括微凸起阵列、介质储槽和衬垫的贴44。然而,敷贴器装置10同样可以使用没有介质储槽的微凸起阵列。在这种情况下,微凸起阵列用作预处理,随后通过单独的通过皮肤输送介质或采样的装置进行施加介质。作为选择,例如对于通过皮肤输送疫苗,该微凸起阵列可将介质作为涂层结合在微凸起阵列上。敷贴器装置10同样可用来冲击其他微穿刺元件压靠角质层,例如Godshall等人的US 5,879,326和Zuck的WO 99/29364,这些披露结合于此作参考。
除了只用单手击发装置10之外,装置10同样设计成只用单手操作(即使得弹簧加载活塞14松开并使得贴44冲击皮肤)。由松开锁定机构致动敷贴器装置10通过施加在敷贴器盖件16的向下力以及将敷贴器装置的第二端42击发压靠皮肤来实现。盖件16通过定位在装置主体12和盖件之间的压紧弹簧24向上偏置。盖件16包括从盖件向下延伸的销46。当盖件16下压抵抗压紧弹簧24的偏置时,销46接触柔性指部28上的斜面48以便将柔性指部向外运动并将柔性指部28的锁栓30从卡扣26松开。这松开活塞14并且活塞向下运动,用贴44冲击角质层。
图3表示在装置已经松开并且贴已经施加到角质层之后的敷贴器装置10。压紧弹簧24选择成在该装置松开之前必须实现预定的压紧力。该压紧力造成角质层由保持件34的第二端42延展,使得皮肤在贴44冲击皮肤时处于最佳的张力下。由压紧弹簧24施加的压紧力最好选择成造成第二端42对于皮肤施加大约0.01~100Mpa范围内的张力,更优选为0.05~2Mpa。
压紧弹簧24和冲击弹簧20之间的平衡使得可以通过按压盖件16击发活塞14而不造成手指46松开锁定机构。冲击弹簧20选择成适于特定贴的预定冲击以便提供所需刺入。冲击和压紧弹簧的选择进一步描述在这里同时提交的在美国临时专利申请系列号60/240,307中,该申请整体结合于此作参考。
保持件34在击发活塞14之后连接到装置主体12上。保持件34由卡扣连接器连接,与所需松开活塞的力相比,该卡扣连接器需要较小的卡扣力。保持件34同样可通过使得保持件34在垂直于敷贴器轴线的方向滑动到装置主体12内的卡口接头或滑动接头连接到装置主体上。
图4以分解透视图表示盖件16、装置主体12和活塞14。如图4所示,活塞14包括与装置主体12的下边缘54(图3)接合并防止活塞排出装置主体之外的活塞保持突片52。另外,盖件16包括简单地与装置主体12的上边缘58(图3)接合并防止盖件从主体脱出的保持突片(未示出)。
图4同样表示可选择锁定配置,该配置使得盖件16转动到一锁定位置上,在该位置上由于销46与柔性指部28不对齐而不可以致动敷贴器。通过盖件内的窗口60提供盖件16的锁定和未锁定位置的指示。当盖件16处于未锁定位置之外的位置时,销46不与柔性指部28上的斜面对齐,并因此敷贴器不可以松开。在此可选择的锁定结构防止敷贴器装置10无意致动的同时,主体12和盖件16的相对转动需要使用两只手,这在某些情况下是不希望的。
图5和6表示敷贴器80的可选择实施例,敷贴器具有不同的形状和略微不同的击发配置,它们同样可以实现简单单手击发操作。按照此实施例,使用者抓握作为装置手柄的外圆筒81。活塞82可滑动地接合在圆筒81内。如图6所示压缩的冲击弹簧83将活塞82偏置离开圆筒81的顶部或皮肤远端。设置可松开的卡扣机构84(未在图6中详细示出),由此按钮85的下压造成锁栓86缩回,因此锁定压缩弹簧83向下(即在向皮肤的方向上)运动活塞82。具有指示器凹口96的中间壳体87可滑动接合圆筒81的皮肤近端。总体为环形的下壳体87旋到壳体87上。其功能在这里同时提交并结合于此作参考的美国临时专利申请系列号60/240,379详细描述的保持件93旋在圆筒81的皮肤近端上。连接在活塞82上的冲击头94位于保持件93内。冲击头94适于在其皮肤近表面上保持具有多个微凸起的贴(该贴在图6中未示出)。图6中压缩状态下的压紧弹簧95设置在圆筒81和中间壳体87之间。压紧弹簧95在使用者抓握圆筒、将边缘89放置在将要穿刺的皮肤位置上并将装置80压靠皮肤位置时压缩。由于弹簧95压缩,缺口96变得与带97的下边缘对齐。在对齐中,压紧弹簧95处于在边缘89处提供所需压紧力和皮肤延展的预定压缩下。一旦缺口96与带97的下边缘对齐,操作者简单地按压按钮85,松开锁栓86,继而松开活塞82和头94,造成头94冲击微凸起构件压靠患者的皮肤。
按照本发明敷贴器装置10和80已经描述成直立定向,其中贴44从该装置的活塞侧施加,该活塞侧在附图中表示为装置的底部/或皮肤近端。应该理解到该敷贴器装置可用于其他定向(即侧向和颠倒),只要该装置适当压靠将要穿刺的皮肤位置即可。
图7表示使用本发明的角质层刺入构件的实施例。图7以微刀片90的形式表示多个微凸起。微刀片90从具有开口94的金属片92成大致90°角延伸。片92可结合在包括介质储槽和将该贴粘接到角质层上的粘合剂的介质输送贴或介质采样贴中。结合有微凸起的介质输送和采样贴的实例在WO 97/48440,WO 97/48441,WO 97/48442中可以发现。没有储槽的图7微凸起阵列可单独作为皮肤处理施加。
这里使用的术语“微凸起”指的是非常小的角质层穿刺元件,其通常具有小于500μm的长度,最好小于250μm,并穿透角质层进入表皮下层或表皮和真皮层以便造成流血。为了刺入角质层,微凸起最好具有至少10μm的长度,更优选为50μm的长度。通常,微凸起进入皮肤不大于500μm的深度,优选为小于400μm的深度。微凸起可形成不同形状,例如针、真空针、刀片、销、冲孔及其组合。
这里使用的术语“微凸起阵列”指的是多个配置成阵列以便穿刺角质层的微凸起。该微凸起阵列可以通过由薄金属片切割成多个刀片形成并将每个刀片从该片的平面向外折弯形成图7的构形。该微凸起阵列同样可以例如通过连接多个条带的其他方式形成,该条带沿每个条带的边缘具有微凸起。该微凸起阵列可包括注射液体制剂的中空针。
微凸起阵列描述在授予Godshall等人的US 5,879,326,授予Ganderton等人的US 5,814,097,授予Gross等人的US 5,279,544,授予Lee等人的US 5,250,023,授予Gerstel等人的US 3,964,482,授予Kravitz等人的Reissue25,637,和PCT公开号WO 96/37155,WO96/37256,WO 96/17648,WO 97/03718,WO 98/11937,WO 98/00193,WO97/48440,WO 97/48441,WO 97/48442,WO 98/00193,WO 99/64580,WO9828037,WO 98/29298,WO 98/29365,所有这些专利结合于此作参考。
本发明的装置可与介质输送、介质采样或两者结合使用。特别是,本发明的装置与通过皮肤输送药物、通过皮肤采样分析物(例如葡萄糖)或两者结合使用。使用本发明的通过皮肤输送装置包括(但不局限于)被动装置、刺入装置、压力驱动装置和电迁移装置。使用本发明的通过皮肤采样装置包括(但不局限于)被动装置、负压驱动装置、刺入装置和反向电迁移装置。本发明的通过皮肤的装置可以与例如皮肤刺入增强器的增加介质流量的方法结合使用。
本发明的装置可以使用微凸起阵列,该阵列包括通过皮肤输送或采样贴,该贴具有将该贴连接到皮肤上的粘合剂。作为选择,微凸起阵列和输送或采样贴可以是两个带有微凸起阵列的分开的元件,以便在施加输送或采样贴之前预处理。
在本发明已经参考其优选实施例详细描述的同时,对于本领域技术人员将明白可进行多种变型和改型以及采用等同结构,而不偏离本发明。
Claims (16)
1.一种用于冲击刺入构件压靠角质层的装置,其包括
具有第一和第二端的主体;
所述第一端适于容纳该刺入构件;
可滑动地配置在输送主体内以便冲击该刺入构件压靠该角质层的活塞;
适于提供冲击力到该活塞上并偏置所述活塞到所述主体的所述第一端之外的冲击弹簧;其中所述冲击弹簧在所述活塞进一步位于所述主体内时聚集能量,
锁栓机构,所述锁栓机构适于在所述活塞已经充分位于所述主体内时使用单手可松开地将所述活塞与所述主体接合;以及
用于脱开所述锁栓机构的松开机构,由此所述冲击弹簧冲击所述活塞压靠该刺入构件,强迫该刺入构件进入所述角质层。
2.如权利要求1所述的装置,其特征在于,该锁栓机构包括该主体和活塞上的相互接合的锁栓构件。
3.如权利要求2所述的装置,其特征在于,其还包括所述主体上的柔性指部和所述活塞上的止挡,其中所述柔性指部和所述止挡包括所述相互接合的锁栓构件。
4.如权利要求1所述的装置,其特征在于,所述松开机构适于在力施加在所述松开机构上之后松开所述活塞。
5.如权利要求4所述的装置,其特征在于,所述锁栓机构和所述活塞松开机构适于使得每个机构单手操作。
6.如权利要求4所述的装置,其特征在于,其还包括盖件,该盖件可运动地安装在所述主体上以便当所述盖件运动到所述主体上时致动该松开机构。
7.如权利要求6所述的装置,其特征在于,其还包括配置在该主体和该盖件之间的压紧弹簧,该弹簧抵抗该松开机构的启动直到所述压紧弹簧已经充分聚集能量使得所述压紧弹簧施加预定压紧力为止。
8.如权利要求6所述的装置,其特征在于,其还包括用于防止所述盖件相对于所述主体运动的锁定机构,由此防止松开机构的启动。
9.如权利要求8所述的装置,其特征在于,其还包括用于指示何时所述盖件位于所述锁定位置的指示器。
10.如权利要求1所述的装置,其特征在于,当所述活塞已经充分位于所述主体内时所述锁栓机构将所述活塞相对于所述主体自动锁定在击发位置。
11.如权利要求1所述的装置,其特征在于,所述活塞包括施加表面,该表面具有如下形状和尺寸,以便有效施加将被冲击的特定贴。
12.如权利要求11所述的装置,其特征在于,所述施加表面具有包括凸起形状、大致平的形状和构造成与预定身体表面位置相配的形状的组中选出的形状。
13.一种用于冲击微凸起阵列压靠角质层的装置,该装置包括:
装置主体;
安装在装置主体内的活塞,该活塞具有微刀片阵列施加表面;
作用在该装置主体和该活塞之间以便用该微刀片冲击该角质层的冲击弹簧;
可运动地安装在该装置主体上的盖件;
作用在该装置主体和该盖件之间的压紧弹簧;
使用单手一起压缩该装置主体和活塞将活塞锁定在击发位置的锁栓机构;以及
用于从该击发位置松开活塞以便在该压紧弹簧压缩时用微刀片阵列冲击角质层的活塞松开装置。
14.如权利要求13所述的装置,其特征在于,该活塞松开装置包括松开指部。
15.如权利要求14所述的装置,其特征在于,该锁栓机构包括柔性指部和止挡。
16.如权利要求13所述的装置,其特征在于,该压紧弹簧抵抗该活塞松开装置的启动直到达到预定压紧力为止。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24043600P | 2000-10-13 | 2000-10-13 | |
US60/240,436 | 2000-10-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1479588A CN1479588A (zh) | 2004-03-03 |
CN100391404C true CN100391404C (zh) | 2008-06-04 |
Family
ID=22906511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018204627A Expired - Fee Related CN100391404C (zh) | 2000-10-13 | 2001-10-12 | 微刀片阵列的冲击式敷贴器 |
Country Status (24)
Country | Link |
---|---|
US (3) | US20020087182A1 (zh) |
EP (1) | EP1341442B1 (zh) |
JP (1) | JP4198985B2 (zh) |
KR (1) | KR100818545B1 (zh) |
CN (1) | CN100391404C (zh) |
AT (1) | ATE298528T1 (zh) |
AU (2) | AU2001296827B2 (zh) |
BR (1) | BR0114634A (zh) |
CA (1) | CA2425537C (zh) |
CZ (1) | CZ20031035A3 (zh) |
DE (1) | DE60111771T2 (zh) |
ES (1) | ES2243564T3 (zh) |
HK (1) | HK1058889A1 (zh) |
HU (1) | HUP0303583A2 (zh) |
IL (1) | IL155375A0 (zh) |
MA (1) | MA26056A1 (zh) |
MX (1) | MXPA03003301A (zh) |
NO (1) | NO20031682L (zh) |
NZ (1) | NZ525293A (zh) |
PL (1) | PL360978A1 (zh) |
PT (1) | PT1341442E (zh) |
RU (1) | RU2277390C2 (zh) |
WO (1) | WO2002030281A1 (zh) |
ZA (1) | ZA200303632B (zh) |
Families Citing this family (166)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2253549C (en) * | 1996-06-18 | 2005-10-25 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
JP4659332B2 (ja) * | 2000-10-13 | 2011-03-30 | アルザ・コーポレーシヨン | 微小突起を用いて皮膚を穿孔するための装置および方法 |
US7419481B2 (en) * | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
BR0114634A (pt) | 2000-10-13 | 2004-01-27 | Alza Corp | Aplicador por impacto de disposição de microlâmina |
US7108681B2 (en) | 2000-10-16 | 2006-09-19 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
NZ525551A (en) | 2000-10-26 | 2005-09-30 | Alza Corp | Transdermal drug delivery devices having coated microprotrusions |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
FR2822049B1 (fr) | 2001-03-13 | 2003-08-01 | Dbv Medica 1 | Patch destine notamment a depister l'etat de sensibilisation d'un sujet a un allergene, procede de fabrication et utilisation |
US7635488B2 (en) | 2001-03-13 | 2009-12-22 | Dbv Technologies | Patches and uses thereof |
WO2002074173A1 (en) * | 2001-03-16 | 2002-09-26 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
CN100349632C (zh) * | 2001-04-20 | 2007-11-21 | 阿尔扎公司 | 具有包含有益药剂的涂层的微小突出物阵列 |
US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7682318B2 (en) | 2001-06-12 | 2010-03-23 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
EP1404233B1 (en) | 2001-06-12 | 2009-12-02 | Pelikan Technologies Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
EP1404235A4 (en) | 2001-06-12 | 2008-08-20 | Pelikan Technologies Inc | METHOD AND DEVICE FOR A LANZETTING DEVICE INTEGRATED ON A BLOOD CARTRIDGE CARTRIDGE |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
JP4149911B2 (ja) | 2001-06-12 | 2008-09-17 | ペリカン テクノロジーズ インコーポレイテッド | 電気式ランセットアクチュエータ |
ATE497731T1 (de) | 2001-06-12 | 2011-02-15 | Pelikan Technologies Inc | Gerät zur erhöhung der erfolgsrate im hinblick auf die durch einen fingerstich erhaltene blutausbeute |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US20030199810A1 (en) * | 2001-11-30 | 2003-10-23 | Trautman Joseph Creagan | Methods and apparatuses for forming microprojection arrays |
DK1465535T3 (da) * | 2001-12-20 | 2008-04-07 | Alza Corp | Mikrofremspring til gennemstikning af huden med stikdybdestyring |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
DE10222235A1 (de) | 2002-05-16 | 2003-11-27 | Roche Diagnostics Gmbh | Blutentnahmesystem |
CA2516547A1 (en) * | 2002-09-30 | 2004-04-15 | Alza Corporation | Drug delivery device having coated microprojections incorporating vasoconstrictors |
AR042815A1 (es) * | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
WO2004098684A2 (en) * | 2003-05-08 | 2004-11-18 | Novo Nordisk A/S | Skin mountable injection device with a detachable needle insertion actuation |
US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
TW200518771A (en) * | 2003-06-30 | 2005-06-16 | Alza Corp | Formulations for coated microprojections containing non-volatile counterions |
JP2007521092A (ja) * | 2003-07-02 | 2007-08-02 | アルザ・コーポレーシヨン | 小突起アレイの免疫化パッチおよび方法 |
WO2005016441A1 (en) * | 2003-08-04 | 2005-02-24 | Alza Corporation | Method and device for enhancing transdermal agent flux |
EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | METHOD AND APPARATUS FOR PROVIDING IMPROVED SAMPLE CAPTURING DEVICE |
WO2005037095A1 (en) | 2003-10-14 | 2005-04-28 | Pelikan Technologies, Inc. | Method and apparatus for a variable user interface |
CN101415443A (zh) * | 2003-10-23 | 2009-04-22 | 阿尔扎公司 | 涂覆微喷射体的稳定dna组合物 |
CN1897898A (zh) * | 2003-10-24 | 2007-01-17 | 阿尔扎公司 | 用于增强透皮药物传递的预处理方法和系统 |
JP2007509705A (ja) * | 2003-10-28 | 2007-04-19 | アルザ・コーポレーシヨン | タバコ使用頻度を低下させる方法および装置 |
ES2377647T3 (es) | 2003-10-31 | 2012-03-29 | Alza Corporation | Aplicador auto-actuado para ordenamiento de microproyecciones |
CA2552385C (en) * | 2003-12-29 | 2013-07-23 | 3M Innovative Properties Company | Medical devices and kits including same |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
FR2866553B1 (fr) * | 2004-02-19 | 2006-06-09 | Dbv Tech | Nouveau type de patch |
WO2005094526A2 (en) | 2004-03-24 | 2005-10-13 | Corium International, Inc. | Transdermal delivery device |
BRPI0509897A (pt) * | 2004-04-13 | 2007-08-07 | Alza Corp | aparelho e método para distribuição transdérmica de múltiplas vacinas |
CN101827301B (zh) | 2004-04-16 | 2016-01-20 | 杜比实验室特许公司 | 用于创建音频场景的设备和方法 |
JP5007427B2 (ja) | 2004-05-13 | 2012-08-22 | アルザ コーポレイション | 副甲状腺ホルモン剤の経皮送達のための装置および方法 |
EP1751546A2 (en) | 2004-05-20 | 2007-02-14 | Albatros Technologies GmbH & Co. KG | Printable hydrogel for biosensors |
WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
TW200626196A (en) * | 2004-09-08 | 2006-08-01 | Alza Corp | Microprojection array with improved skin adhesion and compliance |
ATE504328T1 (de) * | 2004-11-18 | 2011-04-15 | 3M Innovative Properties Co | Mikronadelanordungsapplikator und halter |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
WO2006055795A1 (en) | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
AU2005306426B2 (en) | 2004-11-18 | 2011-04-28 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
EP2388078B1 (en) | 2004-11-18 | 2013-03-20 | 3M Innovative Properties Co. | Method of contact coating a microneedle array |
EP1845870A1 (en) * | 2004-11-18 | 2007-10-24 | 3M Innovative Properties Company | Non-skin-contacting microneedle array applicator |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
JP5301985B2 (ja) | 2005-04-07 | 2013-09-25 | スリーエム イノベイティブ プロパティズ カンパニー | ツールフィードバック感知のためのシステム及び方法 |
US20080195035A1 (en) | 2005-06-24 | 2008-08-14 | Frederickson Franklyn L | Collapsible Patch and Method of Application |
EP2474338B1 (en) | 2005-06-27 | 2013-07-24 | 3M Innovative Properties Company | Microneedle array applicator device |
US20070078414A1 (en) * | 2005-08-05 | 2007-04-05 | Mcallister Devin V | Methods and devices for delivering agents across biological barriers |
US20070060937A1 (en) * | 2005-08-30 | 2007-03-15 | Liu Chen H | Safety needle holder |
CN101267896A (zh) * | 2005-09-12 | 2008-09-17 | 阿尔扎公司 | 可涂覆的透皮给药微突起组合件 |
WO2007064486A1 (en) | 2005-11-30 | 2007-06-07 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
US20080039775A1 (en) * | 2006-03-15 | 2008-02-14 | Alza Corporation | Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents to Prevent or Treat Osteopenia |
US9119945B2 (en) * | 2006-04-20 | 2015-09-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US20070299388A1 (en) * | 2006-04-25 | 2007-12-27 | Alza Corporation | Microprojection array application with multilayered microprojection member for high drug loading |
WO2007127811A2 (en) * | 2006-04-25 | 2007-11-08 | Alza Corporation | Microprojection array application with grouped microprojections for high drug loading |
CA2676221C (en) | 2007-01-22 | 2016-12-20 | Corium International, Inc. | Applicators for microneedles |
EP2146689B1 (en) | 2007-04-16 | 2020-08-12 | Corium, Inc. | Solvent-cast microneedle arrays containing active |
WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
JP5178132B2 (ja) * | 2007-10-11 | 2013-04-10 | キヤノン株式会社 | 画像処理システム並びに画像処理方法 |
FR2924350B1 (fr) | 2007-12-03 | 2010-08-13 | Dbv Tech | Procede et compositions pour la vaccination par voie cutanee |
FR2924349B1 (fr) | 2007-12-03 | 2010-01-01 | Dbv Tech | Methode de desensibilitation aux allergenes |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
WO2010124255A2 (en) * | 2009-04-24 | 2010-10-28 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
WO2011005894A1 (en) * | 2009-07-07 | 2011-01-13 | Naya Touch, Inc. | Dermal roller with therapeutic microstructures |
RU2508135C2 (ru) | 2009-07-31 | 2014-02-27 | 3М Инновейтив Пропертиз Компани | Матрица полых микроигл |
CA2792848C (en) * | 2010-03-17 | 2017-07-04 | Nanomed Devices, Inc. | A built-in non-verbal instructional device integratable to applicators |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
JP6327852B2 (ja) | 2010-05-04 | 2018-05-23 | コリウム インターナショナル, インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
CN102971038B (zh) | 2010-05-04 | 2016-02-03 | 考里安国际公司 | 微针施加器 |
JP5562138B2 (ja) * | 2010-06-24 | 2014-07-30 | シスメックス株式会社 | 微細孔形成装置 |
WO2013015136A1 (ja) * | 2011-07-27 | 2013-01-31 | 久光製薬株式会社 | アプリケータ |
US9443061B2 (en) | 2011-08-16 | 2016-09-13 | Elwha Llc | Devices and methods for recording information on a subject's body |
US9286615B2 (en) * | 2011-08-16 | 2016-03-15 | Elwha Llc | Devices and methods for recording information on a subject's body |
US9772270B2 (en) | 2011-08-16 | 2017-09-26 | Elwha Llc | Devices and methods for recording information on a subject's body |
AU2012304641B2 (en) | 2011-09-07 | 2015-08-13 | Kindeva Drug Delivery L.P. | Delivery system for hollow microneedle arrays |
US9498611B2 (en) | 2011-10-06 | 2016-11-22 | Hisamitsu Pharmaceutical Co., Inc. | Applicator |
WO2013055638A1 (en) | 2011-10-12 | 2013-04-18 | 3M Innovative Properties Company | Integrated microneedle array delivery system |
EP2766067B1 (en) * | 2011-10-12 | 2020-04-22 | 3M Innovative Properties Company | Integrated microneedle array delivery system |
WO2014058746A1 (en) | 2012-10-10 | 2014-04-17 | 3M Innovative Properties Company | Force-controlled applicator for applying a microneedle device to skin |
EP2906285B1 (en) | 2012-10-10 | 2019-06-12 | 3M Innovative Properties Company | Applicator for applying a microneedle device to skin |
EP2919849B1 (en) | 2012-11-16 | 2021-01-06 | Kindeva Drug Delivery L.P. | Force-controlled applicator for applying a microneedle device to skin |
KR102378235B1 (ko) | 2012-12-14 | 2022-03-25 | 민데라 코포레이션 | 바이오마커의 검출 및 취득을 위한 방법 및 디바이스 |
MX2015008157A (es) | 2012-12-21 | 2016-02-22 | Corium Int Inc | Microarreglo para la entrega de agente terapeutico y metodos de uso. |
WO2014110016A1 (en) * | 2013-01-08 | 2014-07-17 | 3M Innovative Properties Company | Applicator for applying a microneedle device to skin |
ES2921481T3 (es) | 2013-03-12 | 2022-08-26 | Corium Inc | Aplicadores para microproyecciones |
EP2968118B1 (en) | 2013-03-15 | 2022-02-09 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
EP2968751B1 (en) | 2013-03-15 | 2022-11-30 | Corium, Inc. | Multiple impact microprojection applicators |
CA2903763C (en) | 2013-03-15 | 2021-11-16 | Corium International, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
ES2761580T3 (es) | 2013-03-15 | 2020-05-20 | Corium Inc | Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación |
KR101712413B1 (ko) * | 2013-03-22 | 2017-03-06 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 카운터 조립체를 포함하는 마이크로니들 어플리케이터 |
CN105263562B (zh) | 2013-05-31 | 2018-09-21 | 3M创新有限公司 | 微针注射和输注设备及其使用方法 |
CN105283216B (zh) * | 2013-05-31 | 2018-01-26 | 3M创新有限公司 | 包括倒置致动器的微针注入设备 |
CN105246541B (zh) | 2013-05-31 | 2018-01-16 | 3M创新有限公司 | 包括双覆盖件的微针注射设备 |
US10232158B2 (en) | 2013-09-18 | 2019-03-19 | Cosmed Pharmaceutical Co., Ltd. | Microneedle patch application device and patch holder |
KR101423590B1 (ko) * | 2013-12-31 | 2014-07-25 | 주식회사 라온 | 마이크로 니들 스탬프 |
WO2015168210A1 (en) * | 2014-04-30 | 2015-11-05 | Kimberly-Clark Worldwide, Inc. | Transdermal drug delivery apparatus and methods |
EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
US10070886B2 (en) | 2015-04-22 | 2018-09-11 | Medline Industries, Inc. | Method of harvesting tissue using sequential sections of a two dimensional array of needles |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
JP2017023404A (ja) | 2015-07-22 | 2017-02-02 | 日本写真印刷株式会社 | マイクロニードルパッチ用インパクト付加型アプリケータ及び先端部材 |
BR112018012526B1 (pt) * | 2015-12-21 | 2022-08-09 | Medrx Co., Ltd | Alojamento de aplicador de adesivo de microagulha, e, aplicador de adesivo de microagulha |
US9918932B2 (en) | 2016-02-19 | 2018-03-20 | Zosano Pharma Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines |
CN109069816B (zh) | 2016-03-16 | 2022-03-25 | 考司美德制药株式会社 | 微针贴片支架 |
KR101746048B1 (ko) | 2016-09-13 | 2017-06-12 | 주식회사 라파스 | 마이크로니들 패치 어플리케이터 |
WO2018139504A1 (ja) | 2017-01-25 | 2018-08-02 | コスメディ製薬株式会社 | マイクロニードルパッチ適用装置 |
JP6931217B2 (ja) | 2017-03-28 | 2021-09-01 | コスメディ製薬株式会社 | 水溶性シート状製剤のアプリケータ |
EP3672570A1 (en) | 2017-08-23 | 2020-07-01 | Zosano Pharma Corporation | Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches |
US11660264B2 (en) | 2017-08-23 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
BR112020007566A2 (pt) | 2017-10-17 | 2020-09-24 | 3M Innovative Properties Company | aplicador para aplicar uma matriz de microagulhas à pele |
AU2019211652A1 (en) | 2018-01-24 | 2020-07-30 | Cosmed Pharmaceutical Co., Ltd. | Tight-binding device for micro-needle |
US11660265B2 (en) | 2018-06-28 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
KR20210086599A (ko) * | 2018-08-30 | 2021-07-08 | 니프로 가부시키가이샤 | 마이크로 니들 어플리케이터 |
JP7172293B2 (ja) * | 2018-08-30 | 2022-11-16 | ニプロ株式会社 | マイクロニードルアプリケータ |
JP7099189B2 (ja) * | 2018-08-30 | 2022-07-12 | ニプロ株式会社 | マイクロニードルアプリケータ |
DE102019200563A1 (de) * | 2019-01-17 | 2020-07-23 | Lts Lohmann Therapie-Systeme Ag | Applikator |
JP2020179168A (ja) | 2019-04-25 | 2020-11-05 | コスメディ製薬株式会社 | 水溶性シート状製剤のアプリケータ2 |
DE102019122948A1 (de) * | 2019-08-27 | 2021-03-04 | Lts Lohmann Therapie-Systeme Ag | Applikator, Applikationssystem sowie Verfahren zum Verschieben eines Stempels |
US20220253917A1 (en) * | 2021-02-11 | 2022-08-11 | Christian Saxon | Method for Generating a Shopping and Educational Experience |
JP2024512870A (ja) * | 2021-09-28 | 2024-03-21 | バイオリンク インコーポレイテッド | 微小針アレイベースの持続的分析物監視デバイスのための微小針エンクロージャおよびアプリケータデバイス |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
US6039172A (en) * | 1996-04-12 | 2000-03-21 | Odme International B.V. | Device for processing a disc-shaped substrate as well as a station suitable for being coupled to such a device |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US240379A (en) * | 1881-04-19 | Portable clock | ||
US240307A (en) * | 1881-04-19 | And andrew eppler | ||
US3470011A (en) * | 1967-02-07 | 1969-09-30 | American Cyanamid Co | Process for applying liquid biologicals to applicators for intracutaneous injection |
US3605744A (en) * | 1969-04-22 | 1971-09-20 | Edward M Dwyer | Injection apparatus and method of injecting |
BE795384A (fr) | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
US4577630A (en) * | 1984-02-14 | 1986-03-25 | Becton, Dickinson And Co. | Reusable breach loading target pressure activated lancet firing device |
US4628929A (en) * | 1985-08-16 | 1986-12-16 | American Hospital Supply Corporation | Retractable blade bleeding time device |
EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
FR2696334B1 (fr) * | 1992-10-01 | 1994-12-02 | Boudjema J Pascal | Dispositif pour transplantation de greffons capillaires de petit diamètre. |
NZ291205A (en) | 1994-08-18 | 1997-12-19 | Nmt Group Plc | Syringe with self retracting offset needle |
ATE177325T1 (de) | 1994-12-09 | 1999-03-15 | Novartis Erfind Verwalt Gmbh | Transdermales system |
WO1996037256A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical patch for enhancing the delivery of compounds through the skin |
AU5740496A (en) * | 1995-05-22 | 1996-12-11 | General Hospital Corporation, The | Micromechanical device and method for enhancing delivery of compounds through the skin |
DE19525607A1 (de) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
ES2284185T3 (es) * | 1996-05-17 | 2007-11-01 | Roche Diagnostics Operations, Inc. | Aparato para la recogida de muestra liquida organica. |
US5613978A (en) | 1996-06-04 | 1997-03-25 | Palco Laboratories | Adjustable tip for lancet device |
CA2253549C (en) | 1996-06-18 | 2005-10-25 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
US6183434B1 (en) | 1996-07-03 | 2001-02-06 | Spectrx, Inc. | Multiple mechanical microporation of skin or mucosa |
EP0934093B1 (en) | 1996-09-17 | 2003-01-15 | Deka Products Limited Partnership | System for delivery of drugs by transport |
JP4153999B2 (ja) | 1996-12-20 | 2008-09-24 | アルザ・コーポレーション | 経皮作用剤流量を強化するための組成物と方法 |
DE19654391A1 (de) | 1996-12-27 | 1998-07-02 | Basf Ag | Katalysator zur selektiven Herstellung von Propylen aus Propan |
BR9714113A (pt) | 1996-12-31 | 2000-03-21 | Shell Int Research | Plataforma de tirante |
US6093172A (en) | 1997-02-05 | 2000-07-25 | Minimed Inc. | Injector for a subcutaneous insertion set |
US6607509B2 (en) * | 1997-12-31 | 2003-08-19 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
JP3097600B2 (ja) * | 1997-05-30 | 2000-10-10 | 日本電気株式会社 | 角質層穿刺装置 |
US5964718A (en) * | 1997-11-21 | 1999-10-12 | Mercury Diagnostics, Inc. | Body fluid sampling device |
WO1999029364A1 (en) | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
CA2484271C (en) * | 1997-12-31 | 2007-04-24 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
US6030402A (en) * | 1998-04-23 | 2000-02-29 | Thompson; Ronald J. | Apparatus and methods for the penetration of tissue, and the creation of an opening therein |
US6086545A (en) * | 1998-04-28 | 2000-07-11 | Amira Medical | Methods and apparatus for suctioning and pumping body fluid from an incision |
CA2330207C (en) | 1998-06-10 | 2005-08-30 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
GB9817662D0 (en) * | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
US6210420B1 (en) * | 1999-01-19 | 2001-04-03 | Agilent Technologies, Inc. | Apparatus and method for efficient blood sampling with lancet |
DE60007290T2 (de) | 1999-01-28 | 2004-09-23 | Cyto Pulse Sciences, Inc. | Einbringen von makromolekülen in zellen |
US6197040B1 (en) * | 1999-02-23 | 2001-03-06 | Lifescan, Inc. | Lancing device having a releasable connector |
US6258112B1 (en) * | 1999-11-02 | 2001-07-10 | Steven Schraga | Single use lancet assembly |
US6706159B2 (en) * | 2000-03-02 | 2004-03-16 | Diabetes Diagnostics | Combined lancet and electrochemical analyte-testing apparatus |
US6537242B1 (en) * | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
BR0114634A (pt) | 2000-10-13 | 2004-01-27 | Alza Corp | Aplicador por impacto de disposição de microlâmina |
-
2001
- 2001-10-12 BR BR0114634-3A patent/BR0114634A/pt not_active Application Discontinuation
- 2001-10-12 AU AU2001296827A patent/AU2001296827B2/en not_active Ceased
- 2001-10-12 CA CA002425537A patent/CA2425537C/en not_active Expired - Fee Related
- 2001-10-12 US US09/976,763 patent/US20020087182A1/en not_active Abandoned
- 2001-10-12 PL PL01360978A patent/PL360978A1/xx not_active Application Discontinuation
- 2001-10-12 PT PT01977733T patent/PT1341442E/pt unknown
- 2001-10-12 CN CNB018204627A patent/CN100391404C/zh not_active Expired - Fee Related
- 2001-10-12 AU AU9682701A patent/AU9682701A/xx active Pending
- 2001-10-12 RU RU2003110432/14A patent/RU2277390C2/ru not_active IP Right Cessation
- 2001-10-12 EP EP01977733A patent/EP1341442B1/en not_active Expired - Lifetime
- 2001-10-12 CZ CZ20031035A patent/CZ20031035A3/cs unknown
- 2001-10-12 ES ES01977733T patent/ES2243564T3/es not_active Expired - Lifetime
- 2001-10-12 KR KR1020037005242A patent/KR100818545B1/ko not_active IP Right Cessation
- 2001-10-12 JP JP2002533731A patent/JP4198985B2/ja not_active Expired - Fee Related
- 2001-10-12 HU HU0303583A patent/HUP0303583A2/hu unknown
- 2001-10-12 MX MXPA03003301A patent/MXPA03003301A/es active IP Right Grant
- 2001-10-12 AT AT01977733T patent/ATE298528T1/de not_active IP Right Cessation
- 2001-10-12 DE DE60111771T patent/DE60111771T2/de not_active Expired - Lifetime
- 2001-10-12 IL IL15537501A patent/IL155375A0/xx unknown
- 2001-10-12 WO PCT/US2001/031935 patent/WO2002030281A1/en active IP Right Grant
-
2003
- 2003-04-11 NO NO20031682A patent/NO20031682L/no not_active Application Discontinuation
- 2003-04-11 NZ NZ525293A patent/NZ525293A/en unknown
- 2003-05-12 MA MA27150A patent/MA26056A1/fr unknown
- 2003-05-12 ZA ZA200303632A patent/ZA200303632B/en unknown
-
2004
- 2004-03-05 HK HK04101669A patent/HK1058889A1/xx not_active IP Right Cessation
-
2005
- 2005-10-14 US US11/251,488 patent/US9192749B2/en active Active
-
2015
- 2015-11-23 US US14/949,158 patent/US10342963B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
US6039172A (en) * | 1996-04-12 | 2000-03-21 | Odme International B.V. | Device for processing a disc-shaped substrate as well as a station suitable for being coupled to such a device |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100391404C (zh) | 微刀片阵列的冲击式敷贴器 | |
CN1250171C (zh) | 利用微凸起刺入皮肤的装置和方法 | |
AU2004287414B2 (en) | Self-actuating applicator for microprojection array | |
AU2001296827A1 (en) | Microblade array impact applicator | |
CN1479589A (zh) | 用于冲击敷贴器的微凸起构件保持器 | |
CN101287517A (zh) | 用于借助微凸起刺穿皮肤的设备和方法 | |
MXPA06004903A (en) | Self-actuating applicator for microprojection array |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080604 Termination date: 20161012 |