CN100540055C - 用于药物递送的生物可降解嵌段共聚组合物 - Google Patents
用于药物递送的生物可降解嵌段共聚组合物 Download PDFInfo
- Publication number
- CN100540055C CN100540055C CNB038181746A CN03818174A CN100540055C CN 100540055 C CN100540055 C CN 100540055C CN B038181746 A CNB038181746 A CN B038181746A CN 03818174 A CN03818174 A CN 03818174A CN 100540055 C CN100540055 C CN 100540055C
- Authority
- CN
- China
- Prior art keywords
- peg
- block
- biodegradable
- derivant
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
- C08G2261/10—Definition of the polymer structure
- C08G2261/12—Copolymers
- C08G2261/126—Copolymers block
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
- C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups
Abstract
Description
ID | PEG | PEG重量(g) | 乙醇酸交酯(g) | D,L-丙交酯(g) |
D2 | PEG200NF | 30.0 | 7.62 | 28.38 |
D3 | PEG200NF | 33.33 | 5.64 | 21.02 |
D4 | PEG300NF | 57.14 | 4.84 | 18.02 |
D5 | PEG600NF | 50.0 | 4.23 | 15.75 |
D6 | 三甘醇 | 50.0 | 4.23 | 15.77 |
D7 | PEG300NF | 50.25 | 19.75 | - |
D8 | PEG300NF | 86.15 | 24.67 | 9.19 |
D9 | PEG300NF | 100.5 | - | 39.5 |
嵌段共聚物 | LA/GA摩尔比 | PEG1MW | PEG2MW | PEG1/PEG2重量比 | MW(道尔顿) | 备注 |
PLG-PEG-PLG(<u>ABA2</u>) | 75/25 | 1000 | - | 100/0 | 4250 | 水溶性 |
PLG-PEG-PLG(<u>ABA3</u>) | 75/25 | 1450 | - | 100/0 | 3950 | 水溶性 |
PLA-PEG-PLA(<u>ABA4</u>) | 100/0 | 1000 | 1450 | 10/90 | 3980 | 水溶性 |
PLG-PEG-PLG(<u>ABA5</u>) | 75/25 | 1450 | - | 100/0 | 7540 | 水不溶性 |
PLA-PE-PLA(<u>ABA6</u>) | 100/0 | 1000 | 600 | 80/20 | 6500 | 水不溶性 |
Claims (11)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/186,462 US7649023B2 (en) | 2002-06-11 | 2002-06-28 | Biodegradable block copolymeric compositions for drug delivery |
US10/186,462 | 2002-06-28 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910151700XA Division CN101890168A (zh) | 2002-06-28 | 2003-05-29 | 用于药物递送的生物可降解嵌段共聚组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1671362A CN1671362A (zh) | 2005-09-21 |
CN100540055C true CN100540055C (zh) | 2009-09-16 |
Family
ID=29779889
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910151700XA Pending CN101890168A (zh) | 2002-06-28 | 2003-05-29 | 用于药物递送的生物可降解嵌段共聚组合物 |
CNB038181746A Expired - Fee Related CN100540055C (zh) | 2002-06-28 | 2003-05-29 | 用于药物递送的生物可降解嵌段共聚组合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910151700XA Pending CN101890168A (zh) | 2002-06-28 | 2003-05-29 | 用于药物递送的生物可降解嵌段共聚组合物 |
Country Status (8)
Country | Link |
---|---|
US (4) | US7649023B2 (zh) |
EP (2) | EP2106787B1 (zh) |
JP (2) | JP2005535638A (zh) |
KR (2) | KR20050058291A (zh) |
CN (2) | CN101890168A (zh) |
AU (1) | AU2003237288A1 (zh) |
CA (2) | CA2672551C (zh) |
WO (1) | WO2004002456A1 (zh) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1032662E (pt) * | 1997-11-07 | 2006-07-31 | Trillium Therapeutics Inc | Metodos e composicoes para imunomodulacao. |
US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7649023B2 (en) | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
US20030228366A1 (en) * | 2002-06-11 | 2003-12-11 | Chung Shih | Reconstitutable compositions of biodegradable block copolymers |
AU2004224413A1 (en) * | 2003-03-21 | 2004-10-07 | Nexmed (Holdings), Inc. | Prostaglandin compositions for the treatment of erectile dysfunction |
JP2007519756A (ja) * | 2004-01-30 | 2007-07-19 | アンジオテック インターナショナル アーゲー | 拘縮を治療するための組成物および方法 |
US8980300B2 (en) | 2004-08-05 | 2015-03-17 | Advanced Cardiovascular Systems, Inc. | Plasticizers for coating compositions |
EP1781305A2 (en) * | 2004-08-13 | 2007-05-09 | Angiotech International Ag | Compositions and methods using hyaluronic acid and hyaluronidase inhibitors |
US20060034889A1 (en) * | 2004-08-16 | 2006-02-16 | Macromed, Inc. | Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof |
US7597907B2 (en) * | 2004-11-05 | 2009-10-06 | Trustees Of The University Of Pennsylvania | Antioxidant polymer nanocarriers for use in preventing oxidative injury |
US20060275230A1 (en) | 2004-12-10 | 2006-12-07 | Frank Kochinke | Compositions and methods for treating conditions of the nail unit |
KR20070095921A (ko) * | 2004-12-10 | 2007-10-01 | 탈리마 테라퓨틱스 인코포레이티드 | 조갑 단위의 상태를 치료하기 위한 조성물 및 방법 |
CA2618404A1 (en) * | 2005-08-04 | 2007-02-15 | Angiotech International Ag | Block copolymer compositions and uses thereof |
JP2009520040A (ja) * | 2005-12-19 | 2009-05-21 | ファーマイン コーポレーション | 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法 |
WO2008005371A2 (en) * | 2006-06-29 | 2008-01-10 | Medtronic, Inc. | Poly(orthoester) polymers, and methods of making and using same |
GB0620685D0 (en) * | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
ES2421206T3 (es) * | 2006-11-09 | 2013-08-29 | Alcon Research, Ltd. | Matriz de polímero insoluble en agua para el suministro de fármaco |
US20080114076A1 (en) * | 2006-11-09 | 2008-05-15 | Alcon Manufacturing Ltd. | Punctal plug comprising a water-insoluble polymeric matrix |
KR100932613B1 (ko) * | 2007-04-27 | 2009-12-17 | 한남대학교 산학협력단 | 고분자 용융공정을 이용한 약물전달용 생체적합성 고분자나노 미립구의 제조방법 및 그 나노 미립구 |
US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
US8178617B2 (en) | 2007-07-16 | 2012-05-15 | Allvivo Vascular, Inc. | Antimicrobial constructs |
US20110129514A1 (en) * | 2007-09-06 | 2011-06-02 | Hossainy Syed F A | Hygroscopic coating on a balloon device |
US20110137243A1 (en) * | 2007-09-06 | 2011-06-09 | Abbott Cardiovascular Systems Inc. | Coating On A Balloon Device |
US8568786B2 (en) * | 2007-10-27 | 2013-10-29 | The Trustees Of The Universtiy Of Pennsylvania | Method and compositions for polymer nanocarriers containing therapeutic molecules |
US7927629B2 (en) * | 2007-10-27 | 2011-04-19 | The Trustees Of The University Of Pennsylvania | Method and compositions for polymer nanocarriers containing therapeutic molecules |
US8642062B2 (en) | 2007-10-31 | 2014-02-04 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
US20090285873A1 (en) * | 2008-04-18 | 2009-11-19 | Abbott Cardiovascular Systems Inc. | Implantable medical devices and coatings therefor comprising block copolymers of poly(ethylene glycol) and a poly(lactide-glycolide) |
US8475823B2 (en) * | 2008-04-18 | 2013-07-02 | Medtronic, Inc. | Baclofen formulation in a polyorthoester carrier |
US8956642B2 (en) * | 2008-04-18 | 2015-02-17 | Medtronic, Inc. | Bupivacaine formulation in a polyorthoester carrier |
US8916188B2 (en) * | 2008-04-18 | 2014-12-23 | Abbott Cardiovascular Systems Inc. | Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block |
WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
WO2010117668A1 (en) * | 2009-03-30 | 2010-10-14 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
US9155722B2 (en) * | 2009-09-18 | 2015-10-13 | Protherics Salt Lake City, Inc. | Reconstitutable reverse thermal gelling polymers |
WO2011035261A1 (en) * | 2009-09-18 | 2011-03-24 | Protherics Salt Lake City, Inc. | Reconstitutable reverse thermal gelling polymers |
US9504698B2 (en) * | 2009-10-29 | 2016-11-29 | Warsaw Orthopedic, Inc. | Flowable composition that sets to a substantially non-flowable state |
US8470891B2 (en) * | 2009-12-23 | 2013-06-25 | International Business Machines Corporation | Biodegradable block polymers for drug delivery, and methods related thereto |
US9295663B2 (en) | 2010-07-14 | 2016-03-29 | Abbott Cardiovascular Systems Inc. | Drug coated balloon with in-situ formed drug containing microspheres |
KR20130100290A (ko) | 2010-08-30 | 2013-09-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 협착성 병변을 위한 전단 제어 방출 및 혈전 용해 치료법 |
CN103179959A (zh) | 2010-10-20 | 2013-06-26 | 帝斯曼知识产权资产管理有限公司 | 含悬挂亲水基的可生物降解的组合物和相关器械 |
MA34832B1 (fr) * | 2010-12-29 | 2014-01-02 | Medincell | Compositions biodegradables d'administration de medicaments |
US8936784B2 (en) | 2011-10-17 | 2015-01-20 | Poly-Med, Inc. | Absorbable in situ gel-forming system, method of making and use thereof |
CA2852386C (en) * | 2011-10-17 | 2019-05-21 | Poly-Med, Inc. | Absorbable in situ gel-forming system, method of making and use thereof |
MX353280B (es) * | 2012-06-27 | 2018-01-05 | Medincell | Suministro de farmaco biodegradable para las composiciones hidrofobicas. |
RU2015143995A (ru) | 2013-03-14 | 2017-04-20 | Халлюкс, Инк. | Способ лечения инфекций, заболеваний или расстройств ногтевого ложа |
ES2883150T3 (es) | 2014-05-01 | 2021-12-07 | Ingell Tech Holding B V | Copolímero tribloque líquido |
CA2974195A1 (en) * | 2014-10-15 | 2016-04-21 | University Of Connecticut | Bio-reducible self-assembled liquid crystalline block copolymer for drug delivery |
KR20160117050A (ko) | 2015-03-31 | 2016-10-10 | 홍익대학교세종캠퍼스산학협력단 | 생체분해성 고분자를 포함하는 마이크로젤 및 이의 제조방법 |
CA3004849A1 (en) | 2015-11-16 | 2017-05-26 | Georges Gaudriault | A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
EP3600258A1 (en) | 2017-03-20 | 2020-02-05 | Teva Pharmaceuticals International GmbH | Sustained release olanzapine formulaitons |
WO2018183624A1 (en) | 2017-03-29 | 2018-10-04 | The Regents Of The University Of Colorado, A Body Corporate | Reverse thermal gels and their use as vascular embolic repair agents |
CN107163255B (zh) * | 2017-04-21 | 2020-10-20 | 四川大学 | 氧化还原和pH双重响应的无规-接枝型药物载体及方法 |
CA3067269C (en) | 2017-06-13 | 2024-01-09 | The University Of British Columbia | Polymeric paste compositions for drug delivery |
CN107410295B (zh) * | 2017-06-19 | 2020-10-16 | 扬州大学 | 一种粒径小于100纳米的嘧菌酯水悬浮剂及其制备方法 |
US11666527B2 (en) * | 2017-07-17 | 2023-06-06 | Medincell | Biodegradable block copolymer drug delivery composition |
JP7017770B2 (ja) * | 2017-07-31 | 2022-02-09 | 国立大学法人 東京大学 | 解重合性を有する両親媒性ブロック共重合体 |
GB201900258D0 (en) * | 2019-01-08 | 2019-02-27 | Medincell | Pharmaceutical composition |
KR102326634B1 (ko) * | 2019-12-24 | 2021-11-15 | 주식회사 현대바이오랜드 | 고함량 오일을 함유한 나노유화액 제조용 블록공중합체의 제조방법 및 이를 함유하는 화장료 조성물 |
WO2021252889A1 (en) * | 2020-06-12 | 2021-12-16 | Rutgers, The State University Of New Jersey | Nanosphere size control by varying the ratio of copolymer blends |
KR20230088732A (ko) | 2020-09-29 | 2023-06-20 | 옥스포드 유니버시티 이노베이션 리미티드 | 뇌졸중 치료 |
WO2023177300A1 (en) | 2022-03-17 | 2023-09-21 | InnoCore Technologies Holding B.V. | Biodegradable thermoplastic poly(ortho ester) based multiblock copolymers |
WO2024069235A2 (en) | 2022-09-30 | 2024-04-04 | Sixfold Bioscience Ltd. | Compositions containing oligonucleotides with theranostic applications |
Family Cites Families (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4534899A (en) * | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
DE3264401D1 (en) * | 1981-07-31 | 1985-08-01 | Tokyo Sintered Metal Co | Method of manufacturing vent element |
ATE37983T1 (de) * | 1982-04-22 | 1988-11-15 | Ici Plc | Mittel mit verzoegerter freigabe. |
US4438253A (en) * | 1982-11-12 | 1984-03-20 | American Cyanamid Company | Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
GB8416234D0 (en) * | 1984-06-26 | 1984-08-01 | Ici Plc | Biodegradable amphipathic copolymers |
EP0258780B1 (en) | 1986-09-05 | 1993-06-23 | American Cyanamid Company | Polyesters containing alkylene oxide blocks as drug delivery systems |
US4716203A (en) | 1986-09-05 | 1987-12-29 | American Cyanamid Company | Diblock and triblock copolymers |
US5143661A (en) * | 1987-05-26 | 1992-09-01 | American Cyanamid Company | Silicone-hardened pharmaceutical microcapsules |
US5123912A (en) * | 1987-08-26 | 1992-06-23 | United States Surgical Corporation | Absorbable coating composition, coated sutures and method of preparation |
US4830855A (en) * | 1987-11-13 | 1989-05-16 | Landec Labs, Inc. | Temperature-controlled active agent dispenser |
JP2670680B2 (ja) * | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
JPH064540B2 (ja) | 1988-09-14 | 1994-01-19 | 多木化学株式会社 | 医用組成物 |
US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US4911926A (en) * | 1988-11-16 | 1990-03-27 | Mediventures Inc. | Method and composition for reducing postsurgical adhesions |
US5681576A (en) * | 1988-11-16 | 1997-10-28 | Mdv Technologies, Inc. | Method and composition for post surgical adhesion reduction |
US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
US5538739A (en) * | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
JPH0383914A (ja) * | 1989-08-18 | 1991-04-09 | W R Grace & Co | ドラッグキャリアー |
US5306501A (en) * | 1990-05-01 | 1994-04-26 | Mediventures, Inc. | Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers |
US5124151A (en) * | 1990-08-07 | 1992-06-23 | Mediventures Inc. | Drug delivery by injection with thermo-irreversible gels |
US5143731A (en) * | 1990-08-07 | 1992-09-01 | Mediventures Incorporated | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
ATE130517T1 (de) * | 1990-08-08 | 1995-12-15 | Takeda Chemical Industries Ltd | Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff. |
US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
US5626863A (en) * | 1992-02-28 | 1997-05-06 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
AU8935591A (en) * | 1990-10-30 | 1992-05-26 | Alza Corporation | Drug delivery system and method |
JP3067262B2 (ja) * | 1991-03-19 | 2000-07-17 | 大日本インキ化学工業株式会社 | 難燃性熱可塑性樹脂組成物、及び熱可塑性樹脂用難燃剤 |
FR2678168B1 (fr) | 1991-06-28 | 1993-09-03 | Rhone Poulenc Rorer Sa | Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge. |
US5330768A (en) * | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
CA2082839A1 (en) * | 1991-11-18 | 1993-05-19 | John Fairhurst | Pharmaceutical compounds |
US5260066A (en) | 1992-01-16 | 1993-11-09 | Srchem Incorporated | Cryogel bandage containing therapeutic agent |
ATE154240T1 (de) * | 1992-03-12 | 1997-06-15 | Alkermes Inc | Acth enthaltende mikrokugeln mit gesteuerter abgabe |
US5384333A (en) | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
GB9211268D0 (en) | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
US6514533B1 (en) * | 1992-06-11 | 2003-02-04 | Alkermas Controlled Therapeutics, Inc. | Device for the sustained release of aggregation-stabilized, biologically active agent |
US5312437A (en) * | 1992-06-12 | 1994-05-17 | United States Surgical Corporation | Absorbable coating composition and suture coated therewith |
WO1994007469A1 (en) * | 1992-09-25 | 1994-04-14 | Dynagen, Inc. | An immunobooster for delayed release of immunogen |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
US5308501A (en) * | 1993-04-02 | 1994-05-03 | Eckert C Edward | Treatment system for alkaline or acidic solution containing heavy metals |
US5716981A (en) * | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
CN100998565A (zh) * | 1993-07-19 | 2007-07-18 | 血管技术药物公司 | 抗血管生长组合物及使用方法 |
US20030203976A1 (en) * | 1993-07-19 | 2003-10-30 | William L. Hunter | Anti-angiogenic compositions and methods of use |
JP3220331B2 (ja) * | 1993-07-20 | 2001-10-22 | エチコン・インコーポレーテツド | 非経口投与用の吸収性液体コポリマー類 |
US5543158A (en) * | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
US5560993A (en) * | 1994-02-16 | 1996-10-01 | Mitsubishi Jukogyo Kabushiki Kaisha | Oxide-coated silicon carbide material and method of manufacturing same |
DE4406172C2 (de) * | 1994-02-25 | 2003-10-02 | Sanol Arznei Schwarz Gmbh | Polyester |
JP4259610B2 (ja) * | 1994-04-08 | 2009-04-30 | キューエルティー・ユーエスエイ・インコーポレーテッド | 液体デリバリー組成物 |
KR0141431B1 (ko) * | 1994-05-17 | 1998-07-01 | 김상웅 | 생분해성 하이드로겔 고분자 |
US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
US5607686A (en) | 1994-11-22 | 1997-03-04 | United States Surgical Corporation | Polymeric composition |
US5612052A (en) * | 1995-04-13 | 1997-03-18 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
US6413539B1 (en) * | 1996-10-31 | 2002-07-02 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
US6551610B2 (en) * | 1995-04-13 | 2003-04-22 | Poly-Med, Inc. | Multifaceted compositions for post-surgical adhesion prevention |
GB9514285D0 (en) | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
EP0842209B1 (en) * | 1995-07-28 | 2006-10-11 | Genzyme Corporation | Multiblock biodegradable hydrogels for use as controlled release agents for drugs and tissue treatment agents |
KR0180334B1 (ko) | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
US5702717A (en) | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
FR2741628B1 (fr) * | 1995-11-29 | 1998-02-06 | Centre Nat Rech Scient | Nouveaux hydrogels a base de copolymeres trisequences et leur application notamment a la liberation progressive de principes actifs |
US6280745B1 (en) * | 1997-12-23 | 2001-08-28 | Alliance Pharmaceutical Corp. | Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions |
US5711958A (en) * | 1996-07-11 | 1998-01-27 | Life Medical Sciences, Inc. | Methods for reducing or eliminating post-surgical adhesion formation |
US5861174A (en) * | 1996-07-12 | 1999-01-19 | University Technology Corporation | Temperature sensitive gel for sustained delivery of protein drugs |
US6331311B1 (en) * | 1996-12-20 | 2001-12-18 | Alza Corporation | Injectable depot gel composition and method of preparing the composition |
US6201072B1 (en) * | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6004573A (en) | 1997-10-03 | 1999-12-21 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6117949A (en) * | 1998-10-01 | 2000-09-12 | Macromed, Inc. | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6841617B2 (en) * | 2000-09-28 | 2005-01-11 | Battelle Memorial Institute | Thermogelling biodegradable aqueous polymer solution |
US5939453A (en) * | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
US6316011B1 (en) | 1998-08-04 | 2001-11-13 | Madash, Llc | End modified thermal responsive hydrogels |
US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
US6451346B1 (en) * | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
US6923966B2 (en) * | 1999-04-08 | 2005-08-02 | Schering Corporation | Melanoma therapy |
US6287588B1 (en) * | 1999-04-29 | 2001-09-11 | Macromed, Inc. | Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof |
US6579951B1 (en) * | 1999-06-08 | 2003-06-17 | Life Medical Sciences, Inc. | Chain-extended or crosslinked polyethylene oxide/polypropylene oxide/polyethylene oxide block polymer with optional polyester blocks |
KR100360827B1 (ko) * | 1999-08-14 | 2002-11-18 | 주식회사 삼양사 | 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법 |
ATE376414T1 (de) | 1999-09-02 | 2007-11-15 | Nostrum Pharmaceuticals Inc | Pellet formulierung mit gesteuerter freisetzung |
KR100416242B1 (ko) * | 1999-12-22 | 2004-01-31 | 주식회사 삼양사 | 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법 |
EP1266570A4 (en) * | 2000-03-21 | 2006-05-31 | Yuichi Mori | COATING MATERIALS FOR BIOLOGICAL FABRICS, COATED BIOLOGICAL FABRICS AND METHOD FOR COATING BIOLOGICAL TISSUES |
US7018645B1 (en) * | 2000-04-27 | 2006-03-28 | Macromed, Inc. | Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties |
US6589549B2 (en) * | 2000-04-27 | 2003-07-08 | Macromed, Incorporated | Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles |
US6660247B1 (en) * | 2000-06-23 | 2003-12-09 | Battelle Memorial Institute | Multiple stimulus reversible hydrogels |
WO2002030466A2 (en) * | 2000-10-11 | 2002-04-18 | Purdue Research Foundation | Pharmaceutical applications of hydrotropic agents, polymers thereof, and hydrogels thereof |
US6748954B2 (en) * | 2000-10-27 | 2004-06-15 | The Regents Of The University Of Michigan | Drug release from polymer matrices through mechanical stimulation |
KR100446101B1 (ko) | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
TWI246524B (en) * | 2001-01-19 | 2006-01-01 | Shearwater Corp | Multi-arm block copolymers as drug delivery vehicles |
US20040185101A1 (en) * | 2001-03-27 | 2004-09-23 | Macromed, Incorporated. | Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof |
US20030003074A1 (en) * | 2001-06-14 | 2003-01-02 | Macromed, Inc. | Formulations of lymphokines and method of use thereof for local or both local and systemic control of proliferative cell disorders |
US6623729B2 (en) * | 2001-07-09 | 2003-09-23 | Korea Advanced Institute Of Science And Technology | Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer |
IL151288A0 (en) * | 2001-08-27 | 2003-04-10 | Yissum Res Dev Co | Multi-component reverse thermo-sensitive polymeric systems |
US6592899B2 (en) * | 2001-10-03 | 2003-07-15 | Macromed Incorporated | PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water |
US8740973B2 (en) * | 2001-10-26 | 2014-06-03 | Icon Medical Corp. | Polymer biodegradable medical device |
US7649023B2 (en) * | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
US20030228366A1 (en) * | 2002-06-11 | 2003-12-11 | Chung Shih | Reconstitutable compositions of biodegradable block copolymers |
KR100502840B1 (ko) | 2002-09-04 | 2005-07-21 | 학교법인 포항공과대학교 | 약물 담지능력이 우수한 블록 공중합체 미셀 조성물 |
AU2003303513A1 (en) | 2002-12-30 | 2004-07-29 | Angiotech International Ag | Tissue reactive compounds and compositions and uses thereof |
CN1446833A (zh) * | 2003-02-08 | 2003-10-08 | 复旦大学 | 一种温敏性可降解微凝胶及其制备方法 |
US20050058688A1 (en) * | 2003-02-22 | 2005-03-17 | Lars Boerger | Device for the treatment and prevention of disease, and methods related thereto |
JP4459543B2 (ja) | 2003-03-17 | 2010-04-28 | 株式会社メドジェル | 徐放性ハイドロゲル製剤 |
US20040253293A1 (en) * | 2003-06-16 | 2004-12-16 | Afshin Shafiee | Rate controlled release of a pharmaceutical agent in a biodegradable device |
US7179867B2 (en) * | 2003-11-26 | 2007-02-20 | Industrial Technology Research Institute | Thermosensitive biodegradable copolymer |
EP1711159B1 (en) * | 2003-12-30 | 2013-03-20 | Durect Corporation | Solid implants containing a block copolymer for controlled release of a gnrh compound |
US8357391B2 (en) * | 2004-07-30 | 2013-01-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages |
TWI294098B (en) * | 2004-08-06 | 2008-03-01 | Via Tech Inc | Fast boot method and system |
US20060034899A1 (en) * | 2004-08-12 | 2006-02-16 | Ylitalo Caroline M | Biologically-active adhesive articles and methods of manufacture |
US20060046960A1 (en) * | 2004-09-02 | 2006-03-02 | Mckay William F | Controlled and directed local delivery of anti-inflammatory compositions |
JP4654641B2 (ja) * | 2004-09-15 | 2011-03-23 | オムロンヘルスケア株式会社 | 血圧計用カフ |
WO2006039659A1 (en) * | 2004-10-02 | 2006-04-13 | Sri International | Bioadhesive delivery system for transmucosal delivery of beneficial agents |
EP1807018A4 (en) * | 2004-10-21 | 2012-07-04 | Univ Iowa Res Found | SYSTEM FOR CONTROLLED IN-SITU ADMINISTRATION OF MEDICINAL PRODUCTS |
US8246949B2 (en) * | 2004-10-27 | 2012-08-21 | Aciont, Inc. | Methods and devices for sustained in-vivo release of an active agent |
US20060093639A1 (en) * | 2004-10-29 | 2006-05-04 | Starkebaum Warren L | Method and device for destroying body tissue |
CA2612456C (en) | 2005-06-16 | 2017-06-06 | Warner Chilcott Company, Inc. | Gel compositions for topical administration |
JP6415598B2 (ja) | 2014-12-18 | 2018-10-31 | 堺ディスプレイプロダクト株式会社 | 表示装置 |
-
2002
- 2002-06-28 US US10/186,462 patent/US7649023B2/en not_active Expired - Lifetime
-
2003
- 2003-05-29 KR KR1020047021037A patent/KR20050058291A/ko not_active Application Discontinuation
- 2003-05-29 WO PCT/US2003/016987 patent/WO2004002456A1/en active Application Filing
- 2003-05-29 CA CA2672551A patent/CA2672551C/en not_active Expired - Fee Related
- 2003-05-29 JP JP2004517595A patent/JP2005535638A/ja active Pending
- 2003-05-29 CA CA002489771A patent/CA2489771A1/en not_active Abandoned
- 2003-05-29 AU AU2003237288A patent/AU2003237288A1/en not_active Abandoned
- 2003-05-29 EP EP09009993.8A patent/EP2106787B1/en not_active Expired - Lifetime
- 2003-05-29 CN CN200910151700XA patent/CN101890168A/zh active Pending
- 2003-05-29 CN CNB038181746A patent/CN100540055C/zh not_active Expired - Fee Related
- 2003-05-29 KR KR1020097015575A patent/KR100933580B1/ko not_active IP Right Cessation
- 2003-05-29 EP EP03736754A patent/EP1531797A4/en not_active Withdrawn
-
2009
- 2009-06-24 US US12/490,968 patent/US8642666B2/en not_active Expired - Lifetime
- 2009-07-23 JP JP2009171750A patent/JP5121790B2/ja not_active Expired - Fee Related
- 2009-11-30 US US12/627,175 patent/US20100076067A1/en not_active Abandoned
-
2013
- 2013-12-23 US US14/139,148 patent/US9265836B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2489771A1 (en) | 2004-01-08 |
KR20050058291A (ko) | 2005-06-16 |
EP1531797A1 (en) | 2005-05-25 |
CA2672551A1 (en) | 2004-01-08 |
US20100076067A1 (en) | 2010-03-25 |
JP5121790B2 (ja) | 2013-01-16 |
US20090264537A1 (en) | 2009-10-22 |
JP2005535638A (ja) | 2005-11-24 |
CN1671362A (zh) | 2005-09-21 |
JP2009280600A (ja) | 2009-12-03 |
EP2106787A3 (en) | 2010-10-13 |
EP1531797A4 (en) | 2007-05-30 |
KR100933580B1 (ko) | 2009-12-22 |
US9265836B2 (en) | 2016-02-23 |
US8642666B2 (en) | 2014-02-04 |
EP2106787A2 (en) | 2009-10-07 |
AU2003237288A1 (en) | 2004-01-19 |
US20040001872A1 (en) | 2004-01-01 |
US7649023B2 (en) | 2010-01-19 |
WO2004002456A1 (en) | 2004-01-08 |
KR20090086478A (ko) | 2009-08-12 |
US20140113975A1 (en) | 2014-04-24 |
CN101890168A (zh) | 2010-11-24 |
EP2106787B1 (en) | 2020-05-13 |
CA2672551C (en) | 2013-02-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100540055C (zh) | 用于药物递送的生物可降解嵌段共聚组合物 | |
TW592726B (en) | PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water | |
JP5043661B2 (ja) | 逆温度応答性ゲル化特性を有する生分解性ジブロック共重合体およびその使用方法 | |
JP4656725B2 (ja) | 逆熱的ゲル化特性を有する生分解性低分子量トリブロックポリ(ラクチド−co−グリコリド)−ポリエチレングリコールコポリマー | |
RU2232779C2 (ru) | Биоразрушаемые трехблочные сополимеры сложного полиэфира и полиэтиленгликоля, имеющие низкую молекулярную массу и обратимые термические желатинирующие свойства | |
CN100574806C (zh) | 作为药物增溶剂的生物可降解的三嵌段共聚物及其使用方法 | |
ZA200102453B (en) | Biodegradable low molecular weight triblock polyester polythylene glycol copolymers having reverse thermal gelation properties. | |
CN1477952A (zh) | 持续释放疏水药物的组合物及其制备方法 | |
JPH11513985A (ja) | ポリ(エーテル−エステル)ブロックコポリマーを基剤とする感熱生分解性ポリマー | |
JP2003531927A (ja) | トリブロックポリエステルポリエチレングリコールコポリマーの混合物 | |
CN102639593A (zh) | 可复水逆向热凝胶聚合物 | |
US20030228366A1 (en) | Reconstitutable compositions of biodegradable block copolymers | |
MXPA01003316A (en) | Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: PROTHERICS SALT LAKE CITY INC. Free format text: FORMER NAME: MACROMED INCORP. |
|
CP01 | Change in the name or title of a patent holder |
Address after: Utah, USA Patentee after: MACROMED, Inc. Address before: Utah, USA Patentee before: MACROMED, Inc. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20171204 Address after: London, England Patentee after: BTG INTERNATIONAL LTD. Address before: London, England Patentee before: Proserix Pharmaceutical Development Corp. Effective date of registration: 20171204 Address after: London, England Patentee after: Proserix Pharmaceutical Development Corp. Address before: Utah, USA Patentee before: MACROMED, Inc. |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090916 Termination date: 20180529 |