CN100549031C - 突变的无激活作用的IgG2结构域和插入该结构域的抗CD3抗体 - Google Patents
突变的无激活作用的IgG2结构域和插入该结构域的抗CD3抗体 Download PDFInfo
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- CN100549031C CN100549031C CNB971956464A CN97195646A CN100549031C CN 100549031 C CN100549031 C CN 100549031C CN B971956464 A CNB971956464 A CN B971956464A CN 97195646 A CN97195646 A CN 97195646A CN 100549031 C CN100549031 C CN 100549031C
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- Prior art keywords
- antibody
- ala
- ser
- constant region
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Description
Claims (8)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65041096A | 1996-05-20 | 1996-05-20 | |
US08/650,410 | 1996-05-20 | ||
US08/656,586 US5834597A (en) | 1996-05-20 | 1996-05-31 | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
US08/656,586 | 1996-05-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1222162A CN1222162A (zh) | 1999-07-07 |
CN100549031C true CN100549031C (zh) | 2009-10-14 |
Family
ID=27095860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB971956464A Expired - Lifetime CN100549031C (zh) | 1996-05-20 | 1997-05-19 | 突变的无激活作用的IgG2结构域和插入该结构域的抗CD3抗体 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5834597A (zh) |
EP (1) | EP0966485B1 (zh) |
JP (2) | JP3947570B2 (zh) |
CN (1) | CN100549031C (zh) |
AT (1) | ATE407952T1 (zh) |
AU (1) | AU725821B2 (zh) |
CA (1) | CA2255826C (zh) |
DE (1) | DE69738984D1 (zh) |
ES (1) | ES2313736T3 (zh) |
PT (1) | PT966485E (zh) |
WO (1) | WO1997044362A1 (zh) |
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US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
GB9206422D0 (en) * | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
US6129914A (en) * | 1992-03-27 | 2000-10-10 | Protein Design Labs, Inc. | Bispecific antibody effective to treat B-cell lymphoma and cell line |
US5885573A (en) * | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
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1996
- 1996-05-31 US US08/656,586 patent/US5834597A/en not_active Expired - Lifetime
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1997
- 1997-05-19 DE DE69738984T patent/DE69738984D1/de not_active Expired - Lifetime
- 1997-05-19 CA CA002255826A patent/CA2255826C/en not_active Expired - Lifetime
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- 1997-05-19 AT AT97927677T patent/ATE407952T1/de active
- 1997-05-19 PT PT97927677T patent/PT966485E/pt unknown
- 1997-05-19 CN CNB971956464A patent/CN100549031C/zh not_active Expired - Lifetime
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- 1997-05-19 AU AU32083/97A patent/AU725821B2/en not_active Expired
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DE69738984D1 (de) | 2008-10-23 |
PT966485E (pt) | 2008-12-10 |
CA2255826C (en) | 2002-10-01 |
US5834597A (en) | 1998-11-10 |
EP0966485A1 (en) | 1999-12-29 |
JP2002506420A (ja) | 2002-02-26 |
AU725821B2 (en) | 2000-10-19 |
ES2313736T3 (es) | 2009-03-01 |
CN1222162A (zh) | 1999-07-07 |
WO1997044362A1 (en) | 1997-11-27 |
CA2255826A1 (en) | 1997-11-27 |
JP2007106771A (ja) | 2007-04-26 |
EP0966485B1 (en) | 2008-09-10 |
AU3208397A (en) | 1997-12-09 |
EP0966485A4 (en) | 2005-01-19 |
ATE407952T1 (de) | 2008-09-15 |
JP3947570B2 (ja) | 2007-07-25 |
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