CN100574730C - A kind of therapeutic instrument that is used for the treatment of fracture and/or bone does not connect - Google Patents
A kind of therapeutic instrument that is used for the treatment of fracture and/or bone does not connect Download PDFInfo
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- CN100574730C CN100574730C CN200710018228A CN200710018228A CN100574730C CN 100574730 C CN100574730 C CN 100574730C CN 200710018228 A CN200710018228 A CN 200710018228A CN 200710018228 A CN200710018228 A CN 200710018228A CN 100574730 C CN100574730 C CN 100574730C
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- bone
- composite membrane
- negative pressure
- fracture
- therapeutic instrument
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Abstract
The invention discloses a kind of therapeutic instrument that is used for the treatment of fracture and/or bone does not connect, at least include composite membrane, the man machine interface control system, the pressure control module, liquid containing bottle, adopt the composite membrane macromolecule as the encapsulant that produces negative pressure, utilize composite membrane to offer the suitable microenvironment of osteanagenesis and reparation and the effect of somatomedin on the one hand; Utilize negative pressure to promote the effect of osteocyte propagation, enrichment of cell and somatomedin and promotion angiogenic growth on the other hand, on the compound film tube of isolating bone and soft tissue, add and use vacuum suction, can fully utilize film guided bone osteanagenesis and negative pressure-induced osteanagenesis, thus the accelerated bone healing.Therapeutic instrument adopts modularized design, and each assembly is relatively independent, adopts three kinds of powering modes, and has/under-voltage protection function, and microcontroller cooperates the high-precision pressure sensor monitoring that negative pressure pump and air relief valve are controlled; By series operations such as keyboard carry out that negative pressure is provided with, all simultaneously operations and data all can show.
Description
Technical field
The invention belongs to medical apparatus and instruments, particularly a kind of therapeutic instrument that is used for the treatment of fracture and/or bone does not connect.
Background technology
Osseous tissue belongs to slow regenerating tissues, and the fracture patient treatment cycle is long, recovers slow, and 5%～7% fracture patient is arranged owing to multiple reason generation delayed union or disunion.Entering clinical short fracture bone does not connect healing process at present has electromagnetic field, ultrasonic, microwave etc., because the curative effect of these methods do not approved yet widely, and these methods all rely on main equipment, thereby still can not get popularizing widely in medical institutions.
Summary of the invention
In order to overcome the limitation of existing short osteanagenesis therapy, the objective of the invention is to, a kind of therapeutic instrument that is used for the treatment of fracture and/or bone does not connect is provided, this therapeutic instrument is on the basis of the theory that promotes union of fracture at present, select for use composite membrane as the encapsulant that produces negative pressure, utilize the guided bone osteanagenesis principle of film and the effect that negative pressure promotes osteocyte propagation, somatomedin secretion and angiogenic growth, further improve fracture, bone does not connect patient's cure rate, shorten treatment time.
In order to realize above-mentioned task, the present invention adopts following technical scheme:
A kind of therapeutic instrument that is used for the treatment of fracture and/or bone does not connect is characterized in that this therapeutic instrument includes at least:
Composite membrane is used to be coated on around the position of fracture or bone does not connect, and this composite membrane is connected with the silica gel double lumen tube;
The man machine interface control system comprises microcontroller, is connected with keyboard array, LCD MODULE, real-time clock module, RS232 communication module, ADC/ front end circuit, power-supply system and mistake/under-voltage protection module on the microcontroller respectively;
The pressure control module, this pressure control module is made up of negative pressure pump and electromagnetic valve and pressure transducer, and negative pressure pump all adopts LMDS Light Coupled Device to be connected with the microcontroller of man machine interface control system with electromagnetic valve;
One liquid containing bottle, this liquid containing bottle is connected on the negative pressure pump of pressure control module, and links to each other with composite membrane by the silica gel double lumen tube.
Described composite membrane adopts polylactic acid-glycolic guanidine-acetic acid and collagen as basis, and composite membrane is divided into three layers, and both side surface is the macromolecule semipermeable membrane, and pore diameter is used to intercept the loss and the guide tissue regeneration of cell less than 10 μ m; The centre is the spongy film of diameter 50 μ m～200 μ m holes, its structure is very imperfect honeycomb structure foam, be used for supporting and the pressure conduction, the thickness of composite membrane is 3～5mm, and a side of composite membrane is shaped on a plurality of side openings suitable with silica gel double lumen tube diameter in advance, be used for being connected with the silica gel double lumen tube, the silica gel double lumen tube inserts 4cm in the polymer compound film.
Composite membrane utilizes wood template method and the preparation of Breath figure method.Composite membrane is made as a series of radian and shape in advance to be suitable for different positions, and gross thickness is about 3mm～5mm, can surround fracture, bone does not connect position around, the silica gel double lumen tube inserts the interior 4cm of composite membrane, insertion portion has a plurality of side openings.
The pressure control module is made up of negative pressure pump and electromagnetic valve and pressure transducer, adopts the micromachining technology manufacturing, can measure Korrosionsmedium.Signal of sensor is sent into the A/D conversion chip after amplifying through amplifier, and under the driving of 4.096V reference voltage, conversion accuracy can reach 1mV.Make the control accuracy of this pressure transducer control module reach 1mmHg.
Negative pressure pump all adopts LMDS Light Coupled Device to be connected with microcontroller with electromagnetic valve, and when microcontroller provided pressurization signal, negative pressure pump work also provided lasting negative pressure; When microcontroller provided depression signal, electromagnetic valve was opened decompression.All pressurizations and decompression process all carry out under the monitoring of pressure transducer automatically, guarantee that the pressure in the liquid containing bottle is precisely controlled.
1000 milliliters of liquid containing bottle capacity, there are pressure transducer and capacity sensor in inside, and when internal pressure and liquid capacity surpassed the scope of permissible value, holding circuit started and the control cut off between microcontroller and the negative pressure pump is got in touch.Microcontroller detects control and gets in touch when being cut off, and can send/the undervoltage warning signal.
Microcontroller adopts the P89V51RD2 model single-chip microcomputer of Philips company, has the flash of 64kB byte and the RAM of 1kB byte, supports the ISP/IAP function.Under the control of pressure transducer, can accurately regulate and control negative pressure value, guarantee to attract the effectiveness and the safety of process.Simultaneously, system can also write down the treatment record 100 times, comprises treatment zero-time and pressure value.The treatment record can utilize the RS232 interface will treat record and upload on the computer, has realized the storage and the query function of treatment record.
The man machine interface control system comprises microcontroller, is connected with keyboard array, LCD MODULE, real-time clock module, RS232 communication module, ADC/ front end circuit, mistake/undervoltage warning module, power-supply system and mistake/under-voltage protection module on the microcontroller respectively;
Keyboard array adopts ZLG7289 keyboard chip, is connected with microcontroller by four pins.When button was pressed, the ZLG7289 chip can produce an external hardware and interrupt, and had no progeny during the microcontroller response is somebody's turn to do and read key information from the DIO pin, carried out operation accordingly, realized the control of keyboard to complete machine.
The therapeutic instrument that is used for the treatment of fracture and/or bone does not connect of the present invention, adopt composite membrane as osteanagenesis and the encapsulant of repairing the position, produce negative pressure in conjunction with negative pressure pump and electromagnetic valve, utilize negative pressure to promote the effect of osteocyte propagation, somatomedin secretion and angiogenic growth on the one hand; Utilize film to offer the effect of suitable microenvironment, enrichment of cell and the somatomedin of osteanagenesis and reparation on the other hand.Further improve fracture, bone does not connect patient's cure rate, shorten treatment time.
Negative pressure pump adopts modularized design, and each assembly is relatively independent, adopts microcontroller to cooperate the high-precision pressure sensor monitoring that negative pressure pump and air relief valve are controlled; Adopt friendly man machine interface, can carry out a series of control operations such as negative pressure is provided with easily by keyboard, all simultaneously operation and data all show on lcd screen.This portable vacuum extractor adopts three kinds of powering modes, and the overvoltage/undervoltage defencive function is arranged, and guarantees patient safety.
Description of drawings
Fig. 1 is a vacuum suction instrument system composition frame chart;
Fig. 2 is structure of composite membrane and placement location sketch map;
Fig. 3 is a composite membrane manufacturing process sketch map;
Fig. 4 is a pressure control module circuit diagram;
Fig. 5 is the pressure sensor module circuit diagram;
Fig. 6 is power supply design circuit figure;
Fig. 7 is the human-computer interface module design drawing.
The present invention is described in further detail below in conjunction with accompanying drawing.
The specific embodiment
The therapeutic instrument that is used for the treatment of fracture and/or bone does not connect of the present invention's preparation, its theoretical foundation has 2 points: first is film guided bone osteanagenesis theory, provide an isolated microenvironment to bone exactly, make the skeletonization factor can be in Local enrichment, and the interference of soft tissue around not being subjected to, thereby strengthen skeletonization factor, accelerating union of bone fracture.Ultimate principle is to place skim pipe at fracture, bone does not connect position separating different tissues, the favorable environment that foundation can make bone regeneration function at utmost be brought into play, and logical filmed passing tube is blocked on every side the interference of the soft tissue of growth fast.And the required histiocyte of film Guan Nengwei provides the regeneration space, the more important thing is that the microenvironment that it can provide suitable local cells and somatomedin to assemble and discharge increases to bone photo and closes factor concentrations such as cell density and bone morphogenetic protein; Second is negative pressure-induced osteanagenesis theory, and negative pressure can regulate gene expression, promotes osteanagenesis, and the accelerated bone reconstruction promotes the growth of local vascular tissue, promotes the secretion of the local cells factor, at the Local enrichment cell of fracturing.Use vacuum suction isolating to add on the compound film tube of bone and soft tissue, can the most effective strong point in conjunction with these two theories, thus accelerated bone heals.
The theory diagram that is used for the treatment of the fracture and/or the therapeutic instrument of bone does not connect of the present invention includes as shown in Figure 1 at least:
Composite membrane is used to be coated on around the position of fracture or bone does not connect, and this composite membrane is connected with the silica gel double lumen tube;
The man machine interface control system, comprise microcontroller, be connected with keyboard array, liquid crystal display, real-time clock module, RS232 communication module, ADC/ front end circuit, mistake/undervoltage warning module, power-supply system and mistake/under-voltage protection module on the microcontroller respectively;
The pressure control module, this pressure control module is made up of negative pressure pump and electromagnetic valve and pressure transducer, and negative pressure pump all adopts LMDS Light Coupled Device to be connected with the microcontroller of man machine interface control system with electromagnetic valve;
One liquid containing bottle, this liquid containing bottle is connected on the negative pressure pump of pressure control module, and links to each other with composite membrane by the silica gel double lumen tube.
The function of each several part and embodiment:
Polymer compound film is divided into intermediate coat and macromolecule semipermeable membrane, and the about 3～5mm of general thickness is made as different radians and shape in advance to be suitable for different positions, and the position of polymer compound film is placed on around the bone stump, as shown in Figure 2.
1, preparation macromolecule semipermeable membrane:
Give by the hydrophilic tropocollagen molecule of grafting on hydrophobicity PLGA molecule that it is amphipathic, be used for the preparation of semipermeable membrane.Choose then the honeycomb structure aperture be positioned at 10～200 mu m ranges, be single disperse and the timber of different hole shapes as template, through control carbonization, vacuum/impregnating method, its honeycomb structure structure can be transferred on the bioabsorbable polymer material such as PLGA.The wood template method makes up the detailed content of semipermeable membrane:
1) pattern hole structural design:
Design according to pore structure, selected timber directly or after Precision Machining, combination is used as template, the single shaft that obtains pore size even (the single dispersion) is to linear tubulose pore structure.[controllable aperture scope is 10～200 μ m, and contains pit (timber is inherent, and is common＜10 μ m) on its wall.Carbonisation can form a large amount of nano-pores, and porosity is 70～95%.For regulating and control the pore structure on the tubulose hole wall better, also in subsequent technique (dipping), introduce the sub-micron pore of hundreds of nanometer.
2) the membrane material design is with synthetic:
For realizing grafting, with 1, the 6-hexamethylene diamine carries out aminolysis, and end is amino (NH2), to be used for the grafting of bioactive molecule collagen to obtain with polyester PLGA in elder generation.Utilize the amount of XPS quantitative analysis amino.
3) template is to the transformation of semipermeable membrane:
For realizing the accurate transformation of pore structure, adopt nanometer casting-negative norm method, concrete steps are:
According to above-mentioned steps 1) in the design template after vacuum carburization, obtain the carbon porous body, infiltrate soluble-salt and oxidation removal carbon through the high-temperature vacuum fusion successively, obtain solid ' negative norm ' salt porous body, to contain the particulate PLGA solution that is grafted with collagen of submicron salt NaCl at last infiltrates in the negative norm, after ultrasonic warm water desalination, obtain semi-permeable polymer.
4) Breath figure method prepares the detailed content of semipermeable membrane: promptly water polymer waterflooding under mobile humid air environment, can form orderly honeycomb structure structure, advantage is that method is simple, and the hole is arranged regular orderly, having versatility, is that the preparation aperture is usually less than the Perfected process of 10 μ m films.Amphipathic biopolymer in this research is the PLGA of collagen graft modification.The major control factor has: humidity and temperature level, humid air flow velocity, polymer solution concentration size and polymer self physicochemical property etc., can regulate and control the pore size of semipermeable membrane by reconciling these factors.
2, preparation intermediate coat:
Intermediate coat utilizes improved Sal drench filter/freeze-dried method preparation, and can be made into average pore size is the foaming structure of 50～200 μ m and very imperfect honeycomb structure structure, uses as intermediate coat, as shown in Figure 3.
The silica gel double lumen tube adopts the good medical silica-gel manufacturing of biocompatibility, be divided into syringe and suction catheter, the suction catheter external diameter is 3mm～5mm, internal diameter 2mm～4mm, syringe diameter 1mm～2mm, syringe is positioned at the suction catheter tube chamber, and the suction catheter leading portion inserts 4cm in the composite membrane, and insertion portion prepares the side opening of diameter 1mm in advance with the distance of 3mm * 3mm with laser.Syringe one end permeation composite membrane inner surface, the other end and suction catheter are drawn side by side.
The pressure control module is made up of negative pressure pump and electromagnetic valve and pressure transducer, and negative pressure pump all adopts LMDS Light Coupled Device to be connected with microcontroller with electromagnetic valve, as shown in Figure 4.When microcontroller provides pressurization signal (PUMP changes low level into), photoelectrical coupler is communicated with the power supply circuits of the negative pressure pump of being made up of metal-oxide-semiconductor and R4_5, R4_6, and negative pressure pump work also provides lasting negative pressure; When microcontroller provides depression signal (VALVE changes low level into), photoelectrical coupler is communicated with the power supply circuits of the negative pressure pump of being made up of metal-oxide-semiconductor and R4_2, R4_3, and electromagnetic valve is opened decompression.Adopt photoelectric coupled device to replace the control of relay realization to circuit, all pressurizations and decompression process all carry out under the monitoring of pressure transducer automatically, guarantee that the pressure in the liquid containing bottle is precisely controlled.Pressure transducer is arranged on the liquid containing bottle top as shown in Figure 5, adopts the super steady pressure pick off of 85 type silicon piezoresistance types.The employing micromachining technology is made, and is furnished with multiple standards hickeys such as 1/4NPT, 1/8NPT, 1/4BSP; Small size, low-power consumption can be measured Korrosionsmedium.Coupling makes its linearity that can reach 0-100mV under the exciting current of 1.5mA output by the constant current power supply circuits of being made up of stabilivolt and audion.Signal of sensor is sent into the A/D conversion chip after amplifying through amplifier.The A/D conversion chip adopts the MAX1236 chip, and this chip is 12 4 road A/D conversion chips that have the I2C bus, and under the driving of 4.096V reference voltage, conversion accuracy can reach 1mV.Thereby make the control accuracy of this pressure transducer control module can reach 1mmHg.This pressure transducer makes the pressure monitoring in the vacuum suction process realize with digitized form, has effectively promoted the accuracy of monitoring.
1000 milliliters of liquid containing bottle capacity, inner except that pressure transducer is set, also have capacity sensor, when the pressure in the liquid containing bottle and capacity exceeded the scope of permissible value, holding circuit started and the control cut off between microcontroller and the negative pressure pump is got in touch.Microcontroller detects control and gets in touch when being cut off, and can send/the undervoltage warning signal, guarantees patient's safety.
Microcontroller adopts the P89V51RD2 model single-chip microcomputer of Philips company, has the flash of 64kB byte and the RAM of 1kB byte, supports the ISP/IAP function, can use the interior flash of sheet to be EEPROM under the IAP function and use; Can select to support 12 clocks or 6 clock modules by software or ISP.
Power design circuit figure as shown in Figure 6, and AC and DC power supply and three kinds of power supply designs of lithium battery are taked in the design of electric power system.Dc source adopts the Switching Power Supply design, and the 220V alternating voltage is converted to the 12V DC voltage; It is system's power supply that lithium battery adopts the battery of 10.8V, and charging circuit is external.The voltage of input is converted to stable 12V DC voltage through DC-DC conversion chip ADP1148, is 12V system power supplies such as negative pressure pump on the one hand, is converted to 5V voltage through a slice 7805 three terminal regulators on the other hand, is the numerical portion power supply of each system.System preferentially uses DC power supply, and automatically switches to battery powered when can dc source can't power, and guarantees that work process can not interrupt.
The RS232 communication module adopts MAX232 serial ports electrical level transferring chip, can write down the treatment record 100 times, comprises treatment zero-time and pressure value.The treatment record can utilize the RS232 interface will treat record and upload on the computer, carries out the data communication between single-chip microcomputer and the PC.This module is the key modules that vacuum extractor is connected with computer, by the conversion of level, the treatment record of storing in the microcontroller can be uploaded in the computer.
The man machine interface Control System Design as shown in Figure 7, comprise microcontroller, be connected with keyboard array, LCD MODULE, real-time clock module, RS232 communication module, ADC/ front end circuit, mistake/undervoltage warning module, power-supply system and mistake/under-voltage protection module on the microcontroller respectively; Wherein LCD MODULE is made of eight sections LCD array of display of 2 (row) * 20 (individual), can show several data.This LCD display module is in light weight, power consumption is little, peripheral circuit is simple, is the ideal display device of portable system.LCD display module pin directly links to each other with the microcontroller respective pins.ZLG7289 keyboard chip is adopted in the importation, coupling 4 * 5 matrix keyboards, comprise operation, stop, suspending, confirm four function buttons, four direction button and 0-9 totally 10 digital keys, the last pull down resistor of keyboard has 10 times resistance difference, and capacity of resisting disturbance is strong.The ZLG7289 chip is connected with microcontroller by four pins.When button was pressed, the ZLG7289 chip can produce an external hardware and interrupt, and had no progeny during the microcontroller response is somebody's turn to do and read key information from the DIO pin, carried out operation accordingly, realized the control of keyboard to complete machine.
Claims (5)
1. one kind is used for the treatment of the fracture and/or the therapeutic instrument of bone does not connect, it is characterized in that this therapeutic instrument includes at least:
Composite membrane is used for directly being coated on the position of fracture or bone does not connect, and this composite membrane is connected with the silica gel double lumen tube;
The man machine interface control system comprises microcontroller, is connected with keyboard array, LCD MODULE, real-time clock module, RS232 communication module, ADC/ front end circuit, power-supply system and mistake/under-voltage protection module on the microcontroller respectively;
The pressure control module, this pressure control module is made up of negative pressure pump and electromagnetic valve and pressure transducer, and negative pressure pump all adopts LMDS Light Coupled Device to be connected with the microcontroller of man machine interface control system with electromagnetic valve;
One liquid containing bottle, this liquid containing bottle is connected on the negative pressure pump of pressure control module, and links to each other with composite membrane by the silica gel double lumen tube.
2. as claims 1 described therapeutic instrument that is used for the treatment of fracture and/or bone does not connect, it is characterized in that, described composite membrane adopts polylactic acid-glycolic guanidine-acetic acid and collagen as basis, composite membrane is divided into three layers, both side surface is the macromolecule semipermeable membrane, pore diameter is used to intercept the loss and the guide tissue regeneration of cell less than 10 μ m; The centre is the spongy film of diameter 50 μ m～200 μ m holes, its structure is very imperfect honeycomb structure foam, be used for supporting and the pressure conduction, the thickness of composite membrane is 3～5mm, and a side of composite membrane is shaped on a plurality of side openings suitable with silica gel double lumen tube diameter in advance, be used for being connected with the silica gel double lumen tube, the silica gel double lumen tube inserts 4cm in the polymer compound film.
3. as claims 1 described therapeutic instrument that is used for the treatment of fracture and/or bone does not connect, it is characterized in that described silica gel double lumen tube is made up of syringe and suction catheter, suction catheter is connected between composite membrane and the liquid containing bottle, is used for the vacuum suction effect; Described syringe one end permeation composite membrane inner surface, the other end and suction catheter are drawn side by side.
4. the therapeutic instrument that is used for the treatment of fracture and/or bone does not connect as claimed in claim 1; it is characterized in that; described mistake/under-voltage protection module is used for when the pressure of liquid containing bottle exceeds the scope of permissible value, and holding circuit startup and the control of cutting off between microcontroller and the negative pressure pump are got in touch and the buzzing warning.
5. the therapeutic instrument that is used for the treatment of fracture and/or bone does not connect as claimed in claim 1, it is characterized in that described power-supply system is AC and DC, three kinds of power supplies of battery, wherein, dc source adopts the Switching Power Supply design, and alternating current power supply is converted to the 12V DC voltage for the 220V alternating voltage; And battery adopts the 10.8V lithium battery.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710018228A CN100574730C (en) | 2007-07-10 | 2007-07-10 | A kind of therapeutic instrument that is used for the treatment of fracture and/or bone does not connect |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710018228A CN100574730C (en) | 2007-07-10 | 2007-07-10 | A kind of therapeutic instrument that is used for the treatment of fracture and/or bone does not connect |
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| Publication Number | Publication Date |
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| CN101099699A CN101099699A (en) | 2008-01-09 |
| CN100574730C true CN100574730C (en) | 2009-12-30 |
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| CN200710018228A Expired - Fee Related CN100574730C (en) | 2007-07-10 | 2007-07-10 | A kind of therapeutic instrument that is used for the treatment of fracture and/or bone does not connect |
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Granted publication date: 20091230 Termination date: 20120710 |