CN101006939A - Focal prostate cancer conformal radiofrequency ablation electrode - Google Patents

Focal prostate cancer conformal radiofrequency ablation electrode Download PDF

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Publication number
CN101006939A
CN101006939A CN 200710036555 CN200710036555A CN101006939A CN 101006939 A CN101006939 A CN 101006939A CN 200710036555 CN200710036555 CN 200710036555 CN 200710036555 A CN200710036555 A CN 200710036555A CN 101006939 A CN101006939 A CN 101006939A
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sub
conformal
pin
prostate cancer
conduit
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CN 200710036555
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CN100434047C (en
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胡兵
张步林
罗昌渠
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Shanghai Jiaotong University
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Shanghai Jiaotong University
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Abstract

The invention discloses a conformal RF ablation electrode of focal prostate cancer, which is composed of conductor and sleeve, wherein the conductor moves in the sleeve pipe, which mates mutually and strictly; the conductor is hollow pipe with multiple fine-hollow core needles on one end; the sub-needles constitutes fan shaped beam with memory ability, which are recessed into sleeve; the handle is loaded on the rear end of conductor and sleeve.

Description

Focal prostate cancer conformal radiofrequency ablation electrode
Technical field
What the present invention relates to is a kind of electrode of technical field of medical instruments, particularly a kind of focal prostate cancer conformal radiofrequency ablation electrode.
Background technology
Carcinoma of prostate is one of common cancer of elderly men, seriously injures human beings'health.In the prior art, prostate cancer therapy has surgical radical treatment art, endocrine therapy, radiotherapy and minimally-invasive treatment etc.The tumor radio-frequency ablation procedure obtains good effect in solid tumor treatments such as liver, kidneys as Wicresoft's means, and its curative effect obtains clinical approval, and has tried out in prostate cancer therapy, has obtained preliminary curative effect.And because prostate is the flat slightly Semen Castaneae shape in front and back, the bottom is roomy, the tip taper, and the glandular substance of prostate front portion has urethra to pass through, and the rear borrows rectovesical septum adjacent with ampulla of rectum.And carcinoma of prostate sends out in the periphery district well, and is many kitchen ranges property and pleomorphism characteristics, can not implement the targeting radiofrequency ablation therapy to cancer, carries out systematicness and melts and need move shape district body of gland to whole periphery district's body of gland and major part.But, existing tumor radio-frequency ablation electrode (as external RITA, RTC and domestic electrode for the production of Er Fu company) does not all have according to organ morphology design specialized electrode, electrode has multiple, as one pole, bipolar or bundling electrode, and the formed how spherical in shape or elliposoidal of kitchen range that melts.
Through the retrieval of prior art is found that the Chinese invention patent publication number is: CN1554314A, application number 200310122792.1, this patent disclosure a kind of single needle water-cooled radio frequency ablating electrode, it melts kitchen range and is elliposoidal.Find also in the retrieval that the Chinese invention patent publication number is CN2722849Y, application number 200420006962.X, the kitchen range that melts of the radio-frequency (RF) ablation incisxal edge electrode of this patent disclosure is oblate spheroid.All there is above-described deficiency in these two kinds of electrodes, are not suitable for limitation carcinoma of prostate radiofrequency ablation therapy.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of focal prostate cancer conformal radiofrequency ablation electrode is provided, its enforcement " suitable shape " is melted, according to the radian (15~30 °) on prostate periphery district's specific form and surface thereof electrode needle is designed to the fladellum formed by many roots pin, see in the side of this fladellum, sub-pin and conduit have the suitable shape curvature of 15~30 radians.The present invention has realized the suitable shape radio-frequency (RF) ablation of suitable limitation carcinoma of prostate, makes it based on prostatic anatomical features, has structures such as protection prostatic urethra, rectum and prostate nervus vasculairs bundle outside the effective temperature field, avoids the hot injury.
The present invention is achieved by the following technical solutions, and the present invention is made up of conduit and overcoat, and conduit is movable in trocar sheath, closely cooperates mutually, and conduit one end is fixed with the many sub-pins of fine hollow, and sub-pin is formed the fladellum with memory function.In the sub-pin retraction overcoat, revert to fladellum when stretching out, and every root pin keeps extremely strong penetration power in the process of stretching out, see in the side of this fladellum, sub-pin and conduit have the suitable shape curvature of 15~30 radians, conduit and the telescopic tail end handle of packing into.
Described conduit is a hollow pipe, and catheter proximal end is provided with 3~7 sub-pins of fine hollow, when launching fully between the needle point apart from 0.8cm.
Described sub-pin one end all inserts in the catheter port and solid welding, but every root pin inner chamber all communicates with conduit cavity.All can be provided with thermocouple in the free end port of sub-pin, also can only be provided with thermocouple in the free end port of the sub-pin of specific position according to real needs, to detect the temperature of zone of ablation, the compensating line of this thermocouple causes handle from conduit cavity and draws from the tail end mouth.
The conduit of electrode of the present invention leaves cavity with perfusion normal saline and chemotherapy medicinal liquid etc., and many roots pin is formed a fladellum, in this fladellum income trocar sheath, when stretching out the trocar sheath fladellum that just can resile.When conduit to when extrapolation, every root pin all has powerful penetration power, and recovers original fladellum.
The end that described trocar sheath cooperates with sub-pin is designed to 30 ° angle, and the trocar sheath outer surface has the graduated insulating barrier of the 0.5cm of indicating.
The other end of described conduit and the trocar sheath handle of packing into has location, guiding and injection interface on the handle.The handle tail end is mounted with the interface that is connected with the radio-frequency (RF) ablation instrument.Front end at the trocar sheath handle has an injection interface, can be at the free end port liquid medicine injection of the sub-pin that communicates with conduit by this interface.
Compared with prior art; the present invention is because the fladellum that many roots pin constitutes and the plesiomorphism of prostate left and right sides lateral lobe; carcinoma of prostate can be effectively treated in the temperature field of radio frequency heating process; can protect structures such as urethra, rectum and prostate neurovascular bundle to avoid damage again, reach and treat carcinoma of prostate safely effectively.
Description of drawings
Fig. 1 is the front view of the suitable controlled electrode special of shape radio-frequency (RF) ablation of prostate of the present invention.
Fig. 2 is the profilograph of the suitable controlled electrode special of shape radio-frequency (RF) ablation of prostate of the present invention.
Fig. 3 is the partial side view of the suitable controlled electrode special fladellum of shape radio-frequency (RF) ablation of prostate of the present invention.
Among the above-mentioned figure: 1 trocar sheath, 2 trocar sheath insullac, 3 trocar sheath scale marks, 4 handles, 5 conduits, 6 sub-pin fladellums, 7 compensation lead of thermocouple, 8 radio frequency lead-ins, 9 electrode bundles and conduit weld, 10 thermocouples, 11 angles, 12 injecting fluid devices, 13 sealing rings, 14 location sheaths, 15 suitable shape curvatures.
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated: present embodiment has provided detailed embodiment being to implement under the prerequisite with the technical solution of the present invention, but protection scope of the present invention is not limited to following embodiment.
The structure of present embodiment comprises trocar sheath 1, conduit 5, sub-pin 6, handle 4 as shown in Figure 1, 2, 3, the compensating wire 7 of thermocouple 10, radio frequency line and thermocouple, location sheath 14 and injection port 12.Present embodiment trocar sheath 1 is made puncture, location and guiding and is used.Conduit 5 cooperates to be tight clearance fit in trocar sheath 1 each other.Be that conduit 5 can be elastic under the trocar sheath orientation loosely.Conduit 5 is a hollow pipe, conduit 5 one ends are settled 3~7 sub-pins 6 of trickle hollow, make by material with memory performance, the external diameter of sub-pin 6 is 0.4mm, and each sub-pin 6 needle tip spacing when launching fully is 0.8cm, can regulate unfolded size according to different parts, sub-pin 6 one ends all insert in conduit one end, be welded to each other fasteningly, and every root pin 6 inner chambers all communicate with conduit cavity, and sub-pin free port can settle thermocouple 10 or hollow can annotate normal saline or chemotherapy medicinal liquid.Many roots pin is formed the fladellum of certain form mutually, see in the side of this fladellum, sub-pin and conduit have the suitable shape curvature (Fig. 3) of 15~30 radians, when conduit 5 income trocar sheaths 1, this fladellum is along with in the distortion retraction trocar sheath 1, when conduit 5 is released, sub-pin Shu Huifu fladellum original shape.In addition, trocar sheath one end is that angle 11 is made puncture usefulness, and the outer surface of trocar sheath 1 holds is with graduated insulating barrier.Conduit 5 all is incorporated with in the handle 4 of location, guiding with the tail end of trocar sheath 1, and the compensating wire 7 of radio frequency line and thermocouple is drawn with the radio-frequency (RF) ablation instrument from the handle tail end and linked to each other, and the handle front end is equipped with the injection interface that can be connected with syringe.
It is the straight shape acicular texture of 16G that the trocar sheath 1 of prostate cancer conformal radio-frequency ablation electrode of the present invention adopts external diameter, can clear demonstration under the guiding in real time of Transrectal Ultrasound, guaranteeing that trocar sheath 1 accurately is inserted into the target area of being treated from the prostate tip, thereby avoid damage is caused at positions such as prostatic urethra, membranous urethra, prostate nervus vasculairs bundle, rectum and bladder.Trocar sheath 1 all is surrounded by insulating barrier 2 except that angle 11 end 0.5cm places are exposed, insulating barrier 2 indicates the scale of 0.5cm, and the insulating barrier 2 of trocar sheath 1 is avoided trocar sheath heat production when radio frequency operation and normal surrounding tissue is caused the hot injury.When trocar sheath 1 is punctured to target, location sheath 14 by handle 4 promotes conduit 5 forward, thereby sub-pin 6 is launched along prostate one lateral lobe, Luo Lu sub-pin bundle 6 has just constituted radio-frequency field like this, unfolded sub-pin bundle 6 sides have 15~30 ° suitable shape curvature 15, this suitable shape curvature 15 can be provided with according to the radian in the big or small prostate periphery district of difference, and the length of sub-pin bundle 6 can be regulated according to the size and the shape of area for treatment.Radio frequency lead-in 8 is drawn from the afterbody of handle 4, is connected by the main frame of plug with the radiofrequency ablation therapy system.
Be provided with thermocouple 10 in the free end port of sub-pin 6, to detect the temperature of zone of ablation, the compensating line of this thermocouple causes handle from conduit cavity and draws with main frame from the tail end mouth and link to each other, finish the transmission of signal, by main frame temperature control is carried out in the treatment target area, avoid the too high and underheat of area for treatment temperature, realize the Temperature Feedback accurate treatment.Can carry out the injection of normal saline or medicine by 12 pairs of treatments of injecting fluid device target area in therapeutic process, normal saline or medicine enter the target area by the sub-pin 6 that links to each other with conduit 5 inner chambers.Cool off the temperature of sub-pin 6 by injecting normal saline, prevent to organize carbonization and then expansion to melt the scope of kitchen range, but also the direct injection chemotherapeutics to the target area.
In an embodiment of the present invention, for guaranteeing the premium properties of prostate cancer conformal radio-frequency ablation electrode, optimized choice has been made in the selection of counter electrode each several part, and its biocompatibility meets the regulation of GB/T16886.1-2001 simultaneously, and selected selection is cheap.

Claims (9)

1, a kind of focal prostate cancer conformal radiofrequency ablation electrode, form by conduit and overcoat, it is characterized in that conduit is movable in trocar sheath, closely cooperates mutually, conduit is a hollow pipe, conduit one end is fixed with the many sub-pins of fine hollow, and sub-pin is formed the fladellum with memory function, in the sub-pin retraction overcoat, revert to fladellum when stretching out, conduit and the telescopic tail end handle of packing into.
2, focal prostate cancer conformal radiofrequency ablation electrode according to claim 1 is characterized in that: described catheter proximal end is fixed with 3~7 sub-pins of fine hollow.
3, focal prostate cancer conformal radiofrequency ablation electrode according to claim 2 is characterized in that: described 3~7 sub-pins of fine hollow, the distance when launching fully between the needle point is 0.8cm.
4, focal prostate cancer conformal radiofrequency ablation electrode according to claim 1 is characterized in that: described fladellum, see that in its side sub-pin and conduit have the suitable shape curvature of 15~30 radians.
5, according to arbitrary described focal prostate cancer conformal radiofrequency ablation electrode of claim 1-4, it is characterized in that: described sub-pin, one end all insert in the catheter port and solid welding, but every root pin inner chamber all communicates with conduit cavity.
6, according to arbitrary described focal prostate cancer conformal radiofrequency ablation electrode of claim 1-4, it is characterized in that: be equipped with thermocouple in the free end port of described sub-pin, perhaps only be provided with thermocouple in the free end port of parton pin, the compensating line of thermocouple causes handle from conduit cavity and draws from the tail end mouth.
7, focal prostate cancer conformal radiofrequency ablation electrode according to claim 1 is characterized in that: described trocar sheath is into 30 ° angle with the end that sub-pin cooperates.
8, according to claim 1 or 7 described focal prostate cancer conformal radiofrequency ablation electrodes, it is characterized in that: described trocar sheath outer surface has the graduated insulating barrier of the 0.5cm of indicating.
9, focal prostate cancer conformal radiofrequency ablation electrode according to claim 1, it is characterized in that: described handle is provided with location, guiding and injection interface, front end at the trocar sheath handle has an injection interface, and the handle tail end is mounted with the interface that is connected with the radio-frequency (RF) ablation instrument.
CNB2007100365551A 2007-01-18 2007-01-18 Focal prostate cancer conformal radiofrequency ablation electrode Expired - Fee Related CN100434047C (en)

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CN103829967A (en) * 2012-11-28 2014-06-04 上海西门子医疗器械有限公司 Device and method for estimating temperature field, method for determining interest area and CT device
CN103917200A (en) * 2011-09-13 2014-07-09 恩克斯特拉公司 Systems and methods for prostate treatment
CN104287828A (en) * 2014-10-20 2015-01-21 周稼 Flexible hollow radiofrequency treatment electrode
US9198708B2 (en) 2010-03-25 2015-12-01 Nxthera, Inc. Systems and methods for prostate treatment
US9345507B2 (en) 2008-11-06 2016-05-24 Nxthera, Inc. Systems and methods for treatment of BPH
CN105919668A (en) * 2016-04-15 2016-09-07 南京康友医疗科技有限公司 Multi-polar microwave ablation needle
US9526555B2 (en) 2008-11-06 2016-12-27 Nxthera, Inc. Systems and methods for treatment of prostatic tissue
CN107157577A (en) * 2016-03-07 2017-09-15 四川锦江电子科技有限公司 A kind of large area discharge ablating device
CN107157571A (en) * 2016-03-07 2017-09-15 四川锦江电子科技有限公司 A kind of interpolar discharge ablating device
CN107242901A (en) * 2011-06-03 2017-10-13 维兰德·K·沙马 Method and apparatus for ablation of tissue
US9833277B2 (en) 2009-04-27 2017-12-05 Nxthera, Inc. Systems and methods for prostate treatment
US9968395B2 (en) 2013-12-10 2018-05-15 Nxthera, Inc. Systems and methods for treating the prostate
US10194970B2 (en) 2013-12-10 2019-02-05 Nxthera, Inc. Vapor ablation systems and methods
JP2019509042A (en) * 2016-03-10 2019-04-04 ウェーブセンス インコーポレイテッド Prostate fluid biopsy to detect prostate cancer and benign prostatic hypertrophy
US10335222B2 (en) 2012-04-03 2019-07-02 Nxthera, Inc. Induction coil vapor generator
US10342593B2 (en) 2015-01-29 2019-07-09 Nxthera, Inc. Vapor ablation systems and methods
US10702327B2 (en) 2015-05-13 2020-07-07 Boston Scientific Scimed, Inc. Systems and methods for treating the bladder with condensable vapor
US10751107B2 (en) 2017-01-06 2020-08-25 Boston Scientific Scimed, Inc. Transperineal vapor ablation systems and methods
US10772670B2 (en) 2013-03-14 2020-09-15 Boston Scientific Scimed, Inc. Systems and methods for treating prostate cancer
US11246640B2 (en) 2016-12-21 2022-02-15 Boston Scientific Scimed, Inc. Vapor ablation systems and methods

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US9526555B2 (en) 2008-11-06 2016-12-27 Nxthera, Inc. Systems and methods for treatment of prostatic tissue
US11564727B2 (en) 2008-11-06 2023-01-31 Boston Scientific Scimed, Inc. Systems and methods for treatment of prostatic tissue
US10610281B2 (en) 2008-11-06 2020-04-07 Boston Scientific Scimed, Inc. Systems and methods for treatment of prostatic tissue
US9345507B2 (en) 2008-11-06 2016-05-24 Nxthera, Inc. Systems and methods for treatment of BPH
US11331135B2 (en) 2009-04-27 2022-05-17 Boston Scientific Scimed, Inc. Systems and methods for prostate treatment
US10390873B2 (en) 2009-04-27 2019-08-27 Boston Scientific Scimed, Inc. Systems and methods for prostate treatment
US9833277B2 (en) 2009-04-27 2017-12-05 Nxthera, Inc. Systems and methods for prostate treatment
US9198708B2 (en) 2010-03-25 2015-12-01 Nxthera, Inc. Systems and methods for prostate treatment
CN107242901B (en) * 2011-06-03 2021-03-05 维兰德·K·沙马 Method and apparatus for tissue ablation
CN107242901A (en) * 2011-06-03 2017-10-13 维兰德·K·沙马 Method and apparatus for ablation of tissue
CN105816237B (en) * 2011-09-13 2018-06-12 恩克斯特拉公司 For the system and method for prostate treatment
US10987150B2 (en) 2011-09-13 2021-04-27 Boston Scientific Scimed, Inc. Systems and methods for prostate treatment
CN103917200A (en) * 2011-09-13 2014-07-09 恩克斯特拉公司 Systems and methods for prostate treatment
CN105816237A (en) * 2011-09-13 2016-08-03 恩克斯特拉公司 Systems and methods for prostate treatment
US9895185B2 (en) 2011-09-13 2018-02-20 Nxthera, Inc. Systems and methods for prostate treatment
CN103917200B (en) * 2011-09-13 2016-03-30 恩克斯特拉公司 For the system and method for prostate treatment
US10335222B2 (en) 2012-04-03 2019-07-02 Nxthera, Inc. Induction coil vapor generator
CN103829967B (en) * 2012-11-28 2016-06-01 上海西门子医疗器械有限公司 Estimate device and method, the method determining interest district and the CT equipment in temperature field
CN103829967A (en) * 2012-11-28 2014-06-04 上海西门子医疗器械有限公司 Device and method for estimating temperature field, method for determining interest area and CT device
US10772670B2 (en) 2013-03-14 2020-09-15 Boston Scientific Scimed, Inc. Systems and methods for treating prostate cancer
US11857243B2 (en) 2013-03-14 2024-01-02 Boston Scientific Scimed, Inc. Systems and methods for treating prostate cancer
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US11786287B2 (en) 2013-12-10 2023-10-17 Boston Scientific Scimed, Inc. Systems and methods for treating the prostate
US9968395B2 (en) 2013-12-10 2018-05-15 Nxthera, Inc. Systems and methods for treating the prostate
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US10806502B2 (en) 2013-12-10 2020-10-20 Boston Scientific Scimed, Inc. Systems and methods for treating the prostate
CN104287828A (en) * 2014-10-20 2015-01-21 周稼 Flexible hollow radiofrequency treatment electrode
US10342593B2 (en) 2015-01-29 2019-07-09 Nxthera, Inc. Vapor ablation systems and methods
US11559345B2 (en) 2015-01-29 2023-01-24 Boston Scientific Scimed, Inc. Vapor ablation systems and methods
US10702327B2 (en) 2015-05-13 2020-07-07 Boston Scientific Scimed, Inc. Systems and methods for treating the bladder with condensable vapor
US11246641B2 (en) 2015-05-13 2022-02-15 Boston Scientific Scimed, Inc. Systems and methods for treating the bladder with condensable vapor
US11864810B2 (en) 2015-05-13 2024-01-09 Boston Scientific Scimed, Inc. Systems and methods for treating the bladder with condensable vapor
CN107157571A (en) * 2016-03-07 2017-09-15 四川锦江电子科技有限公司 A kind of interpolar discharge ablating device
CN107157577A (en) * 2016-03-07 2017-09-15 四川锦江电子科技有限公司 A kind of large area discharge ablating device
JP2019509042A (en) * 2016-03-10 2019-04-04 ウェーブセンス インコーポレイテッド Prostate fluid biopsy to detect prostate cancer and benign prostatic hypertrophy
CN105919668A (en) * 2016-04-15 2016-09-07 南京康友医疗科技有限公司 Multi-polar microwave ablation needle
US11246640B2 (en) 2016-12-21 2022-02-15 Boston Scientific Scimed, Inc. Vapor ablation systems and methods
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