CN101123947A - 增稠的可涂布暖化型润滑剂 - Google Patents
增稠的可涂布暖化型润滑剂 Download PDFInfo
- Publication number
- CN101123947A CN101123947A CNA2005800485020A CN200580048502A CN101123947A CN 101123947 A CN101123947 A CN 101123947A CN A2005800485020 A CNA2005800485020 A CN A2005800485020A CN 200580048502 A CN200580048502 A CN 200580048502A CN 101123947 A CN101123947 A CN 101123947A
- Authority
- CN
- China
- Prior art keywords
- lubricant
- condom
- thickening
- spreadable warming
- warming lubricant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000314 lubricant Substances 0.000 title claims abstract description 192
- 238000010792 warming Methods 0.000 title claims abstract description 94
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 148
- 239000000203 mixture Substances 0.000 claims abstract description 95
- 229920000126 latex Polymers 0.000 claims abstract description 50
- 239000004816 latex Substances 0.000 claims abstract description 48
- 230000000694 effects Effects 0.000 claims abstract description 39
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 37
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 21
- 239000002562 thickening agent Substances 0.000 claims abstract description 20
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960001631 carbomer Drugs 0.000 claims abstract description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 114
- 230000008719 thickening Effects 0.000 claims description 67
- 229920001223 polyethylene glycol Polymers 0.000 claims description 25
- 239000002202 Polyethylene glycol Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 230000001050 lubricating effect Effects 0.000 claims description 20
- 239000003755 preservative agent Substances 0.000 claims description 15
- 230000035807 sensation Effects 0.000 claims description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 6
- 239000000600 sorbitol Substances 0.000 claims description 6
- 230000000845 anti-microbial effect Effects 0.000 claims description 5
- 239000004599 antimicrobial Substances 0.000 claims description 5
- 230000002335 preservative effect Effects 0.000 claims description 5
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims 7
- 230000001737 promoting effect Effects 0.000 claims 7
- 235000011187 glycerol Nutrition 0.000 abstract description 47
- 239000004094 surface-active agent Substances 0.000 abstract description 3
- 238000009736 wetting Methods 0.000 abstract 1
- 238000000576 coating method Methods 0.000 description 33
- 239000011248 coating agent Substances 0.000 description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 25
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 19
- 239000011159 matrix material Substances 0.000 description 16
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 16
- 239000010408 film Substances 0.000 description 15
- 102100038968 WAP four-disulfide core domain protein 1 Human genes 0.000 description 13
- 239000000499 gel Substances 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 8
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 7
- 230000005012 migration Effects 0.000 description 7
- 238000013508 migration Methods 0.000 description 7
- 239000000934 spermatocidal agent Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 150000001335 aliphatic alkanes Chemical class 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 150000004665 fatty acids Chemical class 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000005461 lubrication Methods 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 5
- 229920001214 Polysorbate 60 Polymers 0.000 description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 230000000840 anti-viral effect Effects 0.000 description 5
- -1 fatty acid ester Chemical class 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 5
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 5
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 5
- 229940113124 polysorbate 60 Drugs 0.000 description 5
- 229920003169 water-soluble polymer Polymers 0.000 description 5
- 239000011701 zinc Substances 0.000 description 5
- 229910052725 zinc Inorganic materials 0.000 description 5
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- 230000000680 avirulence Effects 0.000 description 4
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000003995 emulsifying agent Substances 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 4
- NJTGANWAUPEOAX-UHFFFAOYSA-N molport-023-220-454 Chemical compound OCC(O)CO.OCC(O)CO NJTGANWAUPEOAX-UHFFFAOYSA-N 0.000 description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
- OJTDGPLHRSZIAV-UHFFFAOYSA-N propane-1,2-diol Chemical compound CC(O)CO.CC(O)CO OJTDGPLHRSZIAV-UHFFFAOYSA-N 0.000 description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 3
- 229920001213 Polysorbate 20 Polymers 0.000 description 3
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 3
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 3
- ZAKOWWREFLAJOT-ADUHFSDSSA-N [2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate Chemical group CC(=O)OC1=C(C)C(C)=C2OC(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-ADUHFSDSSA-N 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 210000004392 genitalia Anatomy 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 3
- 239000003883 ointment base Substances 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920005862 polyol Polymers 0.000 description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920001451 polypropylene glycol Polymers 0.000 description 3
- 229920000136 polysorbate Polymers 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229960001295 tocopherol Drugs 0.000 description 3
- 229930003799 tocopherol Natural products 0.000 description 3
- 235000010384 tocopherol Nutrition 0.000 description 3
- 239000011732 tocopherol Substances 0.000 description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 2
- 241000195954 Lycopodium clavatum Species 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 229920001219 Polysorbate 40 Polymers 0.000 description 2
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 150000001721 carbon Chemical group 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid ester group Chemical group C(CCCCCCCCCCC)(=O)O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229960003511 macrogol Drugs 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 229920001281 polyalkylene Polymers 0.000 description 2
- 229920001515 polyalkylene glycol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 2
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 2
- 229940101027 polysorbate 40 Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
- 235000013772 propylene glycol Nutrition 0.000 description 2
- 229960003415 propylparaben Drugs 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 229940044959 vaginal cream Drugs 0.000 description 2
- 239000000522 vaginal cream Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 235000016804 zinc Nutrition 0.000 description 2
- 150000003752 zinc compounds Chemical class 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
- 229960001763 zinc sulfate Drugs 0.000 description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 description 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- LQZFQLVBZRVDLJ-DKWTVANSSA-N (2s)-2-aminobutanedioic acid;zinc Chemical compound [Zn].OC(=O)[C@@H](N)CC(O)=O LQZFQLVBZRVDLJ-DKWTVANSSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 description 1
- VGTSYTYRRZZILH-UHFFFAOYSA-N 2,3-dihydroxypropanoic acid;zinc Chemical compound [Zn].OCC(O)C(O)=O VGTSYTYRRZZILH-UHFFFAOYSA-N 0.000 description 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
- GWXNYJUUTVJQGU-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;zinc Chemical compound [Zn].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O GWXNYJUUTVJQGU-UHFFFAOYSA-N 0.000 description 1
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
- HGSXDBRNFBJIMX-UHFFFAOYSA-N 2-aminoacetic acid;zinc Chemical compound [Zn].NCC(O)=O HGSXDBRNFBJIMX-UHFFFAOYSA-N 0.000 description 1
- TZGPACAKMCUCKX-UHFFFAOYSA-N 2-hydroxyacetamide Chemical compound NC(=O)CO TZGPACAKMCUCKX-UHFFFAOYSA-N 0.000 description 1
- HMFKFHLTUCJZJO-UHFFFAOYSA-N 2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO HMFKFHLTUCJZJO-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- SYCHUQUJURZQMO-UHFFFAOYSA-N 4-hydroxy-2-methyl-1,1-dioxo-n-(1,3-thiazol-2-yl)-1$l^{6},2-benzothiazine-3-carboxamide Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=CS1 SYCHUQUJURZQMO-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
- AMEMLELAMQEAIA-UHFFFAOYSA-N 6-(tert-butyl)thieno[3,2-d]pyrimidin-4(3H)-one Chemical compound N1C=NC(=O)C2=C1C=C(C(C)(C)C)S2 AMEMLELAMQEAIA-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 1
- 101100042630 Caenorhabditis elegans sin-3 gene Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 244000007429 Dieffenbachia seguine Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 241001549219 Onosmodium Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 description 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000001857 anti-mycotic effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000002543 antimycotic Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940096529 carboxypolymethylene Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002638 denervation Effects 0.000 description 1
- 210000004262 dental pulp cavity Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 1
- 229960001083 diazolidinylurea Drugs 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 229960003913 econazole Drugs 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- CEVCTNCUIVEQOY-STXHBLNNSA-N fumagillol Chemical compound C([C@@H](O)[C@H](C1[C@]2(C)[C@H](O2)CC=C(C)C)OC)C[C@@]21CO2 CEVCTNCUIVEQOY-STXHBLNNSA-N 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical class COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000010460 hemp oil Substances 0.000 description 1
- 230000001632 homeopathic effect Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000008384 inner phase Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 150000008040 ionic compounds Chemical class 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 229940113096 isoceteth 20 Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940033357 isopropyl laurate Drugs 0.000 description 1
- 229940089456 isopropyl stearate Drugs 0.000 description 1
- 229960004130 itraconazole Drugs 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 240000004308 marijuana Species 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 229940087419 nonoxynol-9 Drugs 0.000 description 1
- 229920004918 nonoxynol-9 Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
- USNNOSFVQQPXTM-UHFFFAOYSA-N propane-1,2-diol propane-1,2,3-triol prop-1-ene Chemical compound C(C(C)O)O.C=CC.OCC(O)CO USNNOSFVQQPXTM-UHFFFAOYSA-N 0.000 description 1
- MILWSGRFEGYSGM-UHFFFAOYSA-N propane-1,2-diol;propane-1,2,3-triol Chemical compound CC(O)CO.OCC(O)CO MILWSGRFEGYSGM-UHFFFAOYSA-N 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 229950005175 sudoxicam Drugs 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 235000013904 zinc acetate Nutrition 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- SRWMQSFFRFWREA-UHFFFAOYSA-M zinc formate Chemical compound [Zn+2].[O-]C=O SRWMQSFFRFWREA-UHFFFAOYSA-M 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 description 1
- LPEBYPDZMWMCLZ-CVBJKYQLSA-L zinc;(z)-octadec-9-enoate Chemical compound [Zn+2].CCCCCCCC\C=C/CCCCCCCC([O-])=O.CCCCCCCC\C=C/CCCCCCCC([O-])=O LPEBYPDZMWMCLZ-CVBJKYQLSA-L 0.000 description 1
- GAMIYQSIKAOVTG-UHFFFAOYSA-L zinc;2-aminopentanedioate Chemical compound [Zn+2].[O-]C(=O)C(N)CCC([O-])=O GAMIYQSIKAOVTG-UHFFFAOYSA-L 0.000 description 1
- WDHVIZKSFZNHJB-UHFFFAOYSA-L zinc;butanoate Chemical compound [Zn+2].CCCC([O-])=O.CCCC([O-])=O WDHVIZKSFZNHJB-UHFFFAOYSA-L 0.000 description 1
- JDLYKQWJXAQNNS-UHFFFAOYSA-L zinc;dibenzoate Chemical compound [Zn+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 JDLYKQWJXAQNNS-UHFFFAOYSA-L 0.000 description 1
- XDWXRAYGALQIFG-UHFFFAOYSA-L zinc;propanoate Chemical compound [Zn+2].CCC([O-])=O.CCC([O-])=O XDWXRAYGALQIFG-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/02—Contraceptive devices; Pessaries; Applicators therefor for use by males
- A61F6/04—Condoms, sheaths or the like, e.g. combined with devices protecting against contagion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Abstract
Description
%重量丙二醇 | 0 | 50 | 100 | ||||||
%重量甘油99.7% | 100 | 50 | 0 | ||||||
试验号 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
Tmax(℃) | 35.7 | 35.8 | 35.8 | 37.2 | 37.5 | 37.6 | 38.5 | 38.1 | 38.5 |
Tb(℃) | 23.8 | 23.8 | 24.1 | 24.1 | 24.0 | 24.0 | 23.8 | 24.0 | 24.1 |
ΔT样品=Tmax-Tb(℃)-Tsf | 5.7 | 5.8 | 5.5 | 6.9 | 7.3 | 7.4 | 8.5 | 7.9 | 8.2 |
平均暖化,ΔT(℃) | 5.7 | 7.2 | 8.2 | ||||||
粘度(25℃) | ~565.5cps | ~140cps | ~32cps |
经过时间(min) | 液滴体积(μL) | 50%重量丙二醇,50%甘油 | 49.50%重量丙二醇,49.5%重量甘油,0.5%重量PS20 | 甘油 | 甘油,0.5%重量PS20 | 丙二醇 | 丙二醇,0.5%重量PS20 | ||||||
mm | 度 | mm | 度 | mm | 度 | mm | 度 | mm | 度 | mm | 度 | ||
1 | 25 | 7.0 | 39 | 8.0 | 27.4 | 6.0 | 56.4 | 6.5 | 41.5 | 7.0 | 39 | 8.0 | 27.4 |
10 | 25 | 7.0 | 39 | 9.5 | 16.8 | 6.0 | 56.4 | 8.0 | 27.4 | 8.0 | 27.4 | 10.0 | 14.4 |
60 | 25 | 7.5 | 32.7 | 10.5 | 12.5 | 7.0 | 39 | 10.0 | 14.4 | 8.0 | 27.4 | 11.5 | 9.5 |
135 | 25 | 7.5 | 32.7 | 12.0 | 8.4 | 7.5 | 32.7 | - | - | 8.0 | 27.4 | 12.5 | 7.4 |
300 | 25 | 8.0 | 27.4 | 12.5 | 7.4 | 8.0 | 27.4 | 12.0 | 84 | 8.5 | 23.1 | 13.5 | 5.9 |
经过时间(min) | 液滴体积(μL) | 50%重量丙二醇,50%重量甘油 | 49.50%重量丙二醇,49.5%重量甘油,0.5%重量PS20 | 甘油 | 甘油,0.5%重量PS20 | 丙二醇 | 丙二醇,0.5%重量PS20 | ||||||
mm | 度 | mm | 度 | mm | 度 | mm | 度 | mm | 度 | mm | 度 | ||
1 | 25 | 5.0 | 78.9 | 6.0 | 564 | 5.0 | 78.9 | 6.0 | 56.4 | 6.0 | 56.4 | 7.0 | 39 |
10 | 25 | 5.0 | 78.9 | 7.0 | 39 | 5.0 | 78.9 | 6.0 | 56.4 | 6.0 | 56.4 | 7.0 | 39 |
60 | 25 | 5.0 | 78.9 | 9.0 | 19.6 | 5.5 | 67.5 | 8.5 | 23.1 | 6.0 | 56.4 | 8.0 | 27.4 |
135 | 25 | 6.0 | 56.4 | 9.0 | 19.6 | 6.5 | 41.5 | 9.0 | 19.6 | 7.0 | 39 | 9.0 | 19.6 |
300 | 25 | 6.0 | 56.4 | 9.0 | 19.6 | 7.0 | 39 | 10.0 | 14.4 | 7.5 | 32.7 | 9.5 | 16.8 |
经过时间(min) | 液滴体积(μL) | 50%重量丙二醇,50%重量甘油 | 49.75%重量丙二醇,49.75%重量甘油,0.5%重量PS20 | 甘油 | 甘油,0.5%重量PS20 | 丙二醇 | 丙二醇,0.5%重量PS20 | ||||||
mm | 度 | mm | 度 | mm | 度 | mm | 度 | mm | 度 | mm | 度 | ||
1 | 25 | 6.0 | 56.4 | 6.5 | 41.5 | 5.0 | 78.9 | 6.0 | 56.4 | 7.0 | 39 | 7.0 | 39 |
5 | 25 | 7.5 | 32.7 | 10.5 | 12.5 | 5.5 | 41.5 | 8.0 | 27.4 | 8.0 | 27.4 | 80 | 27.4 |
经过时间(min) | 50%重量丙二醇,50%重量甘油 | 49.75%重量丙二醇,49.75%重量甘油,0.5%重量PS20 | 甘油 |
(度) | (度) | (度) | |
1 | 85.06 | 57.45 | 84.86 |
5 | 88.14 | 50.75 | 82.9 |
10 | 86.26 | 48.48 | 79.25 |
50%重量丙二醇,50%重量甘油 | 49.75%重量丙二醇,49.75%重量甘油,0.5%重量PS20 | 甘油 | 甘油,0.5%重量PS20 | 丙二醇 | 丙二醇,0.5%重量PS20 |
(N/m) | (N/m) | (N/m) | (N/m) | (N/m) | (N/m) |
0.046 | 0.037 | 0.067 | 0.036 | 0.0385 | 0.03825 |
时间 | 1周 | 2周 | 3周 | 1周 | 2周 | 3周 |
丙二醇%重量 | 0 | 0 | 0 | 50 | 50 | 50 |
甘油%重量 | 100 | 100 | 100 | 50 | 50 | 50 |
1、2、3周后向避孕套体上的迁移(cm)* | 5 | 4.5 | 5.7 | 13.3 | 18.5 | 18.5 |
1、2、3周后向具有0.5%重量吐温20的避孕套体上的迁移(cm) | 15 | 15.5 | 16.8 | 16.8 | 17.5 | 17 |
组合物A | 组合物B | |
组分 | %重量 | %重量 |
甘油 | 49.725 | 49.475 |
丙二醇 | 49.725 | 49.475 |
卡波普 | 0.25 | 0.25 |
抗微生物防腐剂 | 0.3 | 0.3 |
吐温20 | 0.0 | 0.5 |
经过时间 | 液滴体积(μL) | 组合物A | 组合物B | ||
mm | 度 | mm | 度 | ||
1 | 25 | 7.0 | 39.0 | 7.0 | 39.0 |
10 | 25 | 7.0 | 39.0 | 8.5 | 23.1 |
60 | 25 | 7.0 | 39.0 | 10.0 | 14.4 |
经过时间 | 液滴体积(μL) | 组合物A | 组合物B | ||
mm | 度 | mm | 度 | ||
1 | 25 | 5.0 | 78.9 | 5.5 | 67.5 |
10 | 25 | 5.0 | 78.9 | 7.0 | 39.0 |
60 | 25 | 6.0 | 56.4 | 8.0 | 27.4 |
经过时间 | 液滴体积(μL) | 组合物A | 组合物B | ||
mm | 度 | mm | 度 |
1 | 25 | 5.5 | 67.5 | 6.0 | 56.4 |
5 | 25 | 6.0 | 56.4 | 9.0 | 19.6 |
组合物A | 组合物B |
(N/m) | (N/m) |
0.04600 | 0.03650 |
Claims (19)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/064,284 | 2005-02-23 | ||
US11/064,284 US7709428B2 (en) | 2005-02-23 | 2005-02-23 | Thickened spreadable warming lubricant |
PCT/US2005/009877 WO2006091206A1 (en) | 2005-02-23 | 2005-03-24 | Thickened spreadable warming lubricant |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101123947A true CN101123947A (zh) | 2008-02-13 |
CN101123947B CN101123947B (zh) | 2010-06-16 |
Family
ID=35539347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800485020A Active CN101123947B (zh) | 2005-02-23 | 2005-03-24 | 增稠的可涂布暖化型润滑剂 |
Country Status (13)
Country | Link |
---|---|
US (2) | US7709428B2 (zh) |
EP (1) | EP1853224B1 (zh) |
JP (1) | JP2008531497A (zh) |
KR (1) | KR20070121696A (zh) |
CN (1) | CN101123947B (zh) |
AU (1) | AU2005327970B2 (zh) |
BR (1) | BRPI0520018A2 (zh) |
CA (1) | CA2598588A1 (zh) |
IL (1) | IL184681A (zh) |
MX (1) | MX2007010231A (zh) |
NZ (1) | NZ556589A (zh) |
RU (1) | RU2369381C2 (zh) |
WO (1) | WO2006091206A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101642590B (zh) * | 2009-07-24 | 2012-12-12 | 上海名邦橡胶制品有限公司 | 一种避孕套用高润滑性复配硅油 |
CN109200345A (zh) * | 2018-10-12 | 2019-01-15 | 华熙福瑞达生物医药有限公司 | 一种水溶性润滑液及其制备方法和应用 |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7709428B2 (en) * | 2005-02-23 | 2010-05-04 | Ansell Healthcare Products Llc | Thickened spreadable warming lubricant |
EP2099893A2 (en) | 2006-12-15 | 2009-09-16 | Colgate-Palmolive Company | Liquid detergent composition |
US8425923B2 (en) * | 2007-02-09 | 2013-04-23 | Dow Corning Corporation and McNeil-PPC, Inc. | Lotion composition for personal use |
EP2702980A3 (en) * | 2007-02-09 | 2015-03-11 | Reckitt Benckiser (Brands) Limited | Lotion composition for personal use |
US7726487B2 (en) * | 2007-02-09 | 2010-06-01 | Mcneil-Ppc, Inc. | Complementary personal lubricant compositions |
US8770201B2 (en) * | 2007-10-26 | 2014-07-08 | Glycobiosciences Inc. | Condom with multifunctional coating |
US20120240937A1 (en) * | 2009-12-09 | 2012-09-27 | Glaxosmithkline Llc | Coating for Latex Articles |
US20120213717A1 (en) * | 2011-02-18 | 2012-08-23 | Mcneil-Ppc, Inc. | Soothing Agents |
JP5918531B2 (ja) * | 2011-12-29 | 2016-05-18 | 中島化学産業株式会社 | コンドーム用潤滑剤、及びこれを塗布したコンドーム |
DE102017215713A1 (de) * | 2017-09-06 | 2019-03-07 | Sms Group Gmbh | Verfahren zum Betrieb einer walz- oder hüttentechnischen Anlage |
US20210059915A1 (en) * | 2019-08-30 | 2021-03-04 | L'oreal | Cosmetic composition having a lamellar network |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US629098A (en) * | 1898-10-17 | 1899-07-18 | Byron I Turman | Ore-crusher. |
US4851434A (en) * | 1983-05-27 | 1989-07-25 | Deckner George E | Novel non-irritating moisturizer, compositions containing same and method |
CA1249968A (en) * | 1984-04-05 | 1989-02-14 | Kazuo Kigasawa | Ointment base |
JPS62123466A (ja) * | 1985-11-22 | 1987-06-04 | Kaneo Inoue | 画像フイルム中の輪郭線描き切り方法 |
US5549924A (en) * | 1987-07-17 | 1996-08-27 | Robin Renee Thill Shlenker | Method of forming a membrane, especially a latex or polymer membrane, including a deactivating barrier and indicating layer |
FR2619503A1 (fr) * | 1987-08-20 | 1989-02-24 | Hutchinson | Application de microcapsules a la fabrication d'un dispositif prophylactique en materiau elastomere, comme un preservatif ou analogue, et son procede de fabrication |
US5888441A (en) * | 1988-08-24 | 1999-03-30 | Ansell Healthcare Products Inc. | Preparation of antimicrobial articles |
US5441723A (en) * | 1989-01-31 | 1995-08-15 | Rost, Incorporated | Non-toxic hypocompatible biodegradable germicide |
JPH02292212A (ja) | 1989-04-20 | 1990-12-03 | Tremedic Ab | 殺菌ゲル |
US4983404A (en) * | 1989-06-05 | 1991-01-08 | Warner-Lambert Company | Controlled release flavor system and method of preparation |
US5097697A (en) * | 1990-06-06 | 1992-03-24 | Ansell Incorporated | Method and apparatus for airburst testing condoms and the like |
GB9205988D0 (en) | 1992-03-19 | 1992-04-29 | Dunbar Peter | Shaving gels |
US5985860A (en) * | 1992-06-03 | 1999-11-16 | Toppo; Frank | System for transdermal delivery of pain relieving substances |
US5910316A (en) * | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
US5323544A (en) * | 1993-01-22 | 1994-06-28 | Ansell Incorporated | Method and apparatus for drying coatings or films |
US6007836A (en) * | 1993-05-28 | 1999-12-28 | Vericade, Inc. | Transdermal vasodilator |
GR940100370A (el) | 1993-07-28 | 1994-07-26 | Johnson & Johnson Consumer Products Inc. | Μια σπερμοκτονος λιπαντικη αντι-ιου συνθεση και μεθοδος χρησης της. |
US6075081A (en) * | 1997-04-23 | 2000-06-13 | Ansell Healthcare Products Inc. | Manufacture of rubber articles |
US5514698A (en) * | 1994-03-21 | 1996-05-07 | Ortho Pharmaceutical Corporation | Antifungal vaginal cream composition |
US5592949A (en) * | 1994-06-29 | 1997-01-14 | Moench; Thomas R. | Device for acidic buffering and method for inactivation of pathogens |
FR2728464B1 (fr) * | 1994-12-22 | 1997-04-30 | Innothera Lab Sa | Forme galenique unitaire, son procede d'obtention et ses utilisations |
US6387407B1 (en) * | 1995-09-29 | 2002-05-14 | L.A.M. Pharmaceutical Corporation | Topical drug preparations |
JPH09108257A (ja) * | 1995-10-23 | 1997-04-28 | Shiyouichi Masugi | 蓄光性クリーム及びラテックス製コンドーム |
DE19600076A1 (de) * | 1996-01-03 | 1997-07-10 | Gerold Tebbe | Mikrokapselbeschichtetes flexibles Trägermaterial |
US5649825A (en) * | 1996-03-01 | 1997-07-22 | Ratkus; Victor L. | Dental root canal bacterialcidal lubricant |
JP3386651B2 (ja) * | 1996-04-03 | 2003-03-17 | 株式会社東芝 | 半導体装置の製造方法および半導体製造装置 |
US5885591A (en) * | 1996-07-02 | 1999-03-23 | Johnson & Johnson Consumer Products, Inc. | Personal lubricant compositions |
DE69722911D1 (de) * | 1996-12-20 | 2003-07-24 | Okamoto Ind Inc | Wasserlösliches Gleitmittel für Präservative und mit diesem Gleitmittel behandeltes Präservativ |
US6306514B1 (en) | 1996-12-31 | 2001-10-23 | Ansell Healthcare Products Inc. | Slip-coated elastomeric flexible articles and their method of manufacture |
US6409839B1 (en) * | 1997-06-02 | 2002-06-25 | Msp Corporation | Method and apparatus for vapor generation and film deposition |
US6019922A (en) * | 1997-10-01 | 2000-02-01 | Johnson & Johnson Mfg Sn Bhd | Powder-free medical gloves |
US5977223A (en) * | 1997-12-12 | 1999-11-02 | Ansell Healthcare Products, Inc. | Elastomeric articles |
JP3483449B2 (ja) * | 1998-01-26 | 2004-01-06 | アルプス電気株式会社 | Icカード用コネクタ装置 |
US6302848B1 (en) * | 1999-07-01 | 2001-10-16 | Sonotech, Inc. | In vivo biocompatible acoustic coupling media |
US7084884B1 (en) * | 1998-11-03 | 2006-08-01 | Immersion Corporation | Graphical object interactions |
DK1140857T3 (da) * | 1998-12-23 | 2008-10-20 | Maxim Pharm Inc | Syntese af histamin-dihydrochlorid |
US6139848A (en) * | 1999-02-12 | 2000-10-31 | Mcneil-Ppc, Inc. | Personal lubricant compositions |
WO2000051978A1 (en) * | 1999-03-01 | 2000-09-08 | Nitromed, Inc. | Nitrosated and nitrosylated prostaglandins, compositions and metods of use |
US7064114B2 (en) * | 1999-03-19 | 2006-06-20 | Parker Hughes Institute | Gel-microemulsion formulations |
US6428791B1 (en) * | 1999-04-13 | 2002-08-06 | Alphamed Pharmace Vticals, Corp | Lubrication composition |
US6709725B1 (en) * | 2000-02-29 | 2004-03-23 | Ansell Medical Sdn, Bhd. | Elasomeric article |
US6551608B2 (en) * | 2000-03-06 | 2003-04-22 | Porex Technologies Corporation | Porous plastic media with antiviral or antimicrobial properties and processes for making the same |
JP3660560B2 (ja) * | 2000-05-23 | 2005-06-15 | 株式会社マンダム | ジェル状化粧料 |
JP2004509739A (ja) * | 2000-09-27 | 2004-04-02 | ベリオン インコーポレイテッド | 即時水溶解性カプセルおよびその製法 |
US7086403B2 (en) | 2000-12-05 | 2006-08-08 | Church & Dwight Co., Inc. | Condom with male genital desensitizer lubricant |
JP4023604B2 (ja) * | 2001-03-30 | 2007-12-19 | フューチュラ メディカル ディベロップメンツ リミテッド | 勃起剤組成物を有するコンドーム |
WO2003022962A2 (en) * | 2001-09-13 | 2003-03-20 | Ansell Healthcare Products, Inc. | Microencapsulation coating for gloves |
US20030059489A1 (en) * | 2001-09-24 | 2003-03-27 | Canolio Inc. | Genital lubricating compositions and uses thereof |
JP2003183115A (ja) | 2001-12-17 | 2003-07-03 | Shoko Kagaku Kenkyusho:Kk | 変温潤滑剤 |
ATE469869T1 (de) * | 2001-12-18 | 2010-06-15 | Ansell Healthcare Prod Llc | Handschuh- und kondomformer aus ternärer keramik mit carbid und nitrid |
CN1647376A (zh) | 2002-04-11 | 2005-07-27 | 皇家飞利浦电子股份有限公司 | 具有积分器的多相滤波器 |
US7658941B2 (en) * | 2002-05-01 | 2010-02-09 | Johnson & Johnson Consumer Companies, Inc. | Warming and nonirritating lubricant compositions and method of comparing irritation |
US20040185065A1 (en) * | 2002-05-01 | 2004-09-23 | Nawaz Ahmad | Warming and nonirritating lubricant compositions and method of comparing irritation |
RU2288700C2 (ru) | 2002-05-01 | 2006-12-10 | МакНЕЙЛ-ППС, ИНК. | Согревающие и нераздражающие безводные смазывающие композиции |
EP1620069B1 (en) * | 2002-05-01 | 2008-05-28 | McNEIL-PPC, INC. | Warming and nonirritating lubricant fungicide compositions in the form of a gel |
US7005408B2 (en) * | 2002-05-01 | 2006-02-28 | Mcneil-Ppc, Inc. | Warming and nonirritating lubricant compositions and method of comparing irritation |
US7417013B2 (en) * | 2002-05-01 | 2008-08-26 | Mcneil-Ppc, Inc. | Warming and nonirritating lubricant compositions and method of comparing irritation |
US7695730B2 (en) * | 2002-05-01 | 2010-04-13 | Mcneil-Ppc, Inc. | Warming and nonirritating lubricant compositions and method of comparing irritation |
US20040167039A1 (en) * | 2002-05-01 | 2004-08-26 | Nawaz Ahmad | Warming and nonirritating lubricant compositions and method of comparing irritation |
US7097668B2 (en) * | 2002-09-16 | 2006-08-29 | Combe Incorporated | Temporary hair dye composition |
US6855341B2 (en) * | 2002-11-04 | 2005-02-15 | Jeffrey B. Smith | Anti-viral compositions and methods of making and using the anti-viral compositions |
US20040115250A1 (en) * | 2002-12-17 | 2004-06-17 | Ansell Healthcare Products Inc. | Camomile/aloe vera treated glove |
WO2004071437A2 (en) * | 2003-02-07 | 2004-08-26 | Barmensen, Inc. | Compositions for enhancing sexual responsiveness |
US20050076917A1 (en) * | 2003-10-10 | 2005-04-14 | Biofilm Ip, Llc. | Lubricated condom |
CN1225291C (zh) * | 2003-11-21 | 2005-11-02 | 武汉杰士邦卫生用品有限公司 | 水溶性人体润滑剂 |
US20050130522A1 (en) * | 2003-12-11 | 2005-06-16 | Kaiyuan Yang | Fiber reinforced elastomeric article |
US7037579B2 (en) * | 2003-12-19 | 2006-05-02 | Ansell Healthcare Products Llc | Polymer composite fibrous coating on dipped rubber articles and method |
WO2005081952A2 (en) | 2004-02-26 | 2005-09-09 | Church & Dwight Co., Inc. | Condom with warmth imparting lubricant |
US7709428B2 (en) * | 2005-02-23 | 2010-05-04 | Ansell Healthcare Products Llc | Thickened spreadable warming lubricant |
US20060188528A1 (en) * | 2005-02-23 | 2006-08-24 | Ansell Healthcare Products Llc | Spreadable warming lubricant |
US7405186B2 (en) * | 2005-03-25 | 2008-07-29 | Chemsil Silicones, Inc. | Lubricant compositions, condom products and methods of making same |
US8137735B2 (en) * | 2005-11-10 | 2012-03-20 | Allegiance Corporation | Elastomeric article with antimicrobial coating |
US7971276B2 (en) * | 2005-12-01 | 2011-07-05 | Ansell Healthcare Products, Llc | Glove with hand-friendly coating and method of making |
-
2005
- 2005-02-23 US US11/064,284 patent/US7709428B2/en not_active Expired - Fee Related
- 2005-03-24 AU AU2005327970A patent/AU2005327970B2/en not_active Ceased
- 2005-03-24 RU RU2007135219/15A patent/RU2369381C2/ru not_active IP Right Cessation
- 2005-03-24 MX MX2007010231A patent/MX2007010231A/es active IP Right Grant
- 2005-03-24 JP JP2007556128A patent/JP2008531497A/ja active Pending
- 2005-03-24 EP EP05731480A patent/EP1853224B1/en not_active Expired - Fee Related
- 2005-03-24 CN CN2005800485020A patent/CN101123947B/zh active Active
- 2005-03-24 CA CA002598588A patent/CA2598588A1/en not_active Abandoned
- 2005-03-24 BR BRPI0520018-0A patent/BRPI0520018A2/pt not_active IP Right Cessation
- 2005-03-24 NZ NZ556589A patent/NZ556589A/en unknown
- 2005-03-24 KR KR1020077021852A patent/KR20070121696A/ko not_active Application Discontinuation
- 2005-03-24 WO PCT/US2005/009877 patent/WO2006091206A1/en active Application Filing
-
2007
- 2007-07-17 IL IL184681A patent/IL184681A/en not_active IP Right Cessation
-
2010
- 2010-03-03 US US12/716,786 patent/US8193134B2/en active Active
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101642590B (zh) * | 2009-07-24 | 2012-12-12 | 上海名邦橡胶制品有限公司 | 一种避孕套用高润滑性复配硅油 |
CN109200345A (zh) * | 2018-10-12 | 2019-01-15 | 华熙福瑞达生物医药有限公司 | 一种水溶性润滑液及其制备方法和应用 |
CN109200345B (zh) * | 2018-10-12 | 2020-06-02 | 华熙生物科技股份有限公司 | 一种水溶性润滑液及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
KR20070121696A (ko) | 2007-12-27 |
CN101123947B (zh) | 2010-06-16 |
IL184681A (en) | 2010-12-30 |
US20100160457A1 (en) | 2010-06-24 |
BRPI0520018A2 (pt) | 2009-04-14 |
RU2369381C2 (ru) | 2009-10-10 |
AU2005327970B2 (en) | 2010-08-19 |
WO2006091206A1 (en) | 2006-08-31 |
MX2007010231A (es) | 2007-11-06 |
EP1853224A1 (en) | 2007-11-14 |
CA2598588A1 (en) | 2006-08-31 |
RU2007135219A (ru) | 2009-03-27 |
JP2008531497A (ja) | 2008-08-14 |
US7709428B2 (en) | 2010-05-04 |
IL184681A0 (en) | 2007-12-03 |
US20060189493A1 (en) | 2006-08-24 |
NZ556589A (en) | 2009-05-31 |
AU2005327970A1 (en) | 2006-08-31 |
US8193134B2 (en) | 2012-06-05 |
EP1853224B1 (en) | 2012-01-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101123947B (zh) | 增稠的可涂布暖化型润滑剂 | |
CN101128184B (zh) | 可涂布暖化型润滑剂 | |
JP4712377B2 (ja) | 加温性で無刺激性の無水の潤滑性組成物 | |
US3244589A (en) | Alkyl phenoxy polyethoxy ether spermicidal aerosol | |
EP0665733B1 (en) | Vaginal sponge delivery system | |
WO1994008536A9 (en) | Vaginal sponge delivery system | |
JPH07145063A (ja) | 殺精子・抗ウイルス性潤滑剤組成物およびその使用方法 | |
US7658941B2 (en) | Warming and nonirritating lubricant compositions and method of comparing irritation | |
US20040167039A1 (en) | Warming and nonirritating lubricant compositions and method of comparing irritation | |
US7695730B2 (en) | Warming and nonirritating lubricant compositions and method of comparing irritation | |
KR101046538B1 (ko) | 가온성 및 비자극성 무수 윤활제 조성물 | |
US20130184233A1 (en) | Personal Lubricant Compositions | |
JP2008543731A (ja) | 尿道コンドームおよび液体フェミドーム | |
US20090053163A1 (en) | Warming and nonirritating lubricant compositions and method of comparing irritation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20171013 Address after: New jersey, USA Patentee after: United States LLC Address before: New jersey, USA Patentee before: ANSELL HEALTHCARE PRODUCTS LLC |
|
TR01 | Transfer of patent right |
Effective date of registration: 20180612 Address after: Singapore Singapore Patentee after: SXWELL AUSTRALIA Pty Ltd. Address before: New jersey, USA Patentee before: United States LLC |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20220222 Address after: Room 408, building C7, Guanggu Biological Innovation Park, No. 666, Gaoxin Avenue, Donghu New Technology Development Zone, Wuhan, Hubei Patentee after: WUHAN JISSBON SANITARY PRODUCTS Co.,Ltd. Address before: Singapore, Singapore Patentee before: SXWELL AUSTRALIA Pty Ltd. |
|
TR01 | Transfer of patent right | ||
CP03 | Change of name, title or address |
Address after: Building A1, Phase II, Optics Valley Biological Innovation Park, No. 1, Jiufeng 1st Road, Jiufeng Street, Donghu New Technology Development Zone, 430000, Hubei Province Patentee after: Lefusi Health Industry Co. Address before: Room 408, building C7, Optical Valley Biological Innovation Park, 666 Gaoxin Avenue, Donghu New Technology Development Zone, Wuhan City, Hubei Province, 430000 Patentee before: WUHAN JISSBON SANITARY PRODUCTS Co.,Ltd. |
|
CP03 | Change of name, title or address |