CN101472642B - Micro neddle roller assembly - Google Patents
Micro neddle roller assembly Download PDFInfo
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- CN101472642B CN101472642B CN2007800226769A CN200780022676A CN101472642B CN 101472642 B CN101472642 B CN 101472642B CN 2007800226769 A CN2007800226769 A CN 2007800226769A CN 200780022676 A CN200780022676 A CN 200780022676A CN 101472642 B CN101472642 B CN 101472642B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
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- B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
- B29C45/561—Injection-compression moulding
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- A—HUMAN NECESSITIES
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
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- A61M2210/00—Anatomical parts of the body
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Abstract
The present invention provides a micro needle roller assembly comprising a roller head including an external cylindrical member having a plurality of micro needles mounted on a surface thereof and an internal member placed in the external member and supported to the external member by supporting piece; and a handling member coupled to the internal member for rotating the internal member of the roller head; the micro needles, the external cylindrical member and the internal member being made of polymer resin.
Description
Technical field
The present invention relates to a kind of micro neddle roller assembly, relate more specifically to a kind of for the micro neddle roller assembly through the skin histology delivering drug.
Background technology
Usually, in the method that the medicine percutaneous is carried, medicine is difficult to see through horny layer, so the absorbance of medicine is extremely low.Specifically, the molecular weight of medicine is larger, and the medicine absorbance is just lower.In order to address the above problem, proposed to utilize the technology of microneedle.In this technology, pass the part of skin or the passage of all epidermises by microneedle formation, then pass through these passages with epidermis or the subcuticle of drug delivery to skin.
According to the above technology of utilizing microneedle, the large medicine of delivery of molecules amount easily, such as insulin, hormone medicine etc.In addition, in case microneedle penetrates and chafe corium just naturally Burn or cicatrix.And, thereby the generation of bringing out collagen can improve the colour of skin and make the defying age maximum effect.
Current, utilize micro neddle roller as the tunnel-shaped apparatus for converting.Micro neddle roller comprises the barrel roll head that is formed with a plurality of microneedle thereon, and microneedle forms a plurality of passages at skin when the roller head rotates.The embodiment of micro neddle roller is open in WO 02/47555, WO 02/49711.
Yet in above traditional micro neddle roller, microneedle is made by rustless steel.And microneedle is stretched out from the inside of roller head, thereby can arrange the limited space of pin.Therefore, the distance between the pin reduces limited.
Usually, the about 2mm of the linear range between the pin is difficult to reduce distance between the pin with the maximization therapeutic effect.In addition, in order to reuse porcupine roller, should carry out disinfection to porcupine roller.And, owing to porcupine roller is made by rustless steel, so its manufacturing cost and price improve.
As another prior art, in Korean Utility Model registration No.115807, disclose a kind ofly for forming passage with the instrument of delivering drug at skin, it comprises: circular sheet, each thin plate is formed with a plurality of dermal needles in its end; A plurality of pads, each pad is arranged between the thin plate; Central shaft is assembled thin plate and pad thereon; And a plurality of stiffeners, they are installed in the two ends of central shaft.
Yet the problem of above instrument is that the process of making this device is complicated, therefore is difficult to a large amount of manufacturing installations of very low cost.For example, circular sheet should alternately be assembled, therefore because above-mentioned situation is difficult to make this instrument.Thereby have such defective, that is, above instrument can not be made by the one-shot forming process, and manufacturing time is elongated.
Summary of the invention
Technical problem
Therefore, the present invention is to solve the problems referred to above of traditional micro neddle roller assembly in design, the object of the present invention is to provide a kind of micro neddle roller assembly, and it is simple in structure, can shorten manufacturing time, and can make in enormous quantities with low manufacturing cost.
Another object of the present invention is to provide a kind of micro neddle roller assembly, it can strengthen the efficient that the medicine percutaneous is carried because the distance between the pin is narrow.
Technical scheme
In order to realize above purpose, micro neddle roller assembly according to the present invention comprises: the roller head, this roller head comprises tubular external member and internals, on the surface of described external member a plurality of microneedle are installed, described internals places described external member and supported to be supported to described external member; And handle component, this handle component joins described internals to, is used for making the described internals rotation of described roller head; Described microneedle, described tubular external member and described internals are made by polymer resin.
Here, described internals is the hollow barrel-type member, and described support member is along the radially extension of described internals.And described internals is formed with tubular at two place, end and receives the space.
Described microneedle, described tubular external member and described internals be by making such as the polymer resin of thermosetting resin or thermoplastic resin, and can be integrally formed each other.
On the other hand, described handle component comprises: handle; The first linking arm and the second linking arm from described handle extension; And being formed on projection on the inner surface of described the first linking arm and the second linking arm, described projection is received in the reception space at place, both ends of the described internals that is formed at described roller head.
And the described external member of described roller head is formed with groove in its surface, and described roller head comprises the pin piece that is formed with pin thereon, and described pin piece is received in the described groove.
Here, described groove is along the longitudinal extension of described external member, and has top and width greater than the bottom on described top, and the cross sectional shape of described pin piece is identical with the cross sectional shape of described groove.
Specifically, described groove can be parallel to the axis formation of described tubular external member.Otherwise described groove tilts at a certain angle with respect to the axis of described tubular external member.
Also can comprise the side cover that is fixed to described roller head two side ends according to micro neddle roller assembly of the present invention, each side cover has the opening corresponding with described internals.
Also can comprise vibration generating arrangement and power supply in the space in the described handle that is received in described handle component according to micro neddle roller assembly of the present invention.
Also can comprise according to micro neddle roller assembly of the present invention and to be fixed to described handle and to place lid on the described roller head.
Advantageous effects
Because all structural elements, be the tubular external member, be formed on a plurality of pins on the outer surface of external member and join that internals on the external member is made by polymer resin to and integrally formed each other by support member, so can only simply make by shot forming process according to micro neddle roller assembly of the present invention.
In addition, in micro neddle roller assembly according to the present invention, the pin piece that is formed with microneedle on roller head and its is separately made, then each other assembling.Therefore,, after the roller head unloads, can then new pin piece be installed on the roller head, thereby can reuse roller head and handle component at the pin piece of crossing with the user contact skin.
In addition, can on the pin piece, form respectively the different a plurality of pins of size (diameter and height), therefore user can have based on the body part selection of drug variety, drug dose and coating medicine the pin piece of the pin of desired size, then selected pin piece is installed to the roller head.
Specifically, owing to according to micro neddle roller assembly involving vibrations generating means of the present invention, so microneedle pierces through skin effectively owing to be delivered to the vibration of roller head, thereby improve the drug delivery effect, activate skin histology and can accelerate blood circulation.
In addition, when microneedle pierced through skin, the lid that the blood that the passage that forms from pin spills is placed on the roller head stopped, so user can wholesomely use micro neddle roller assembly.
Specifically, but by the infrared ray softening skin from the infrared generator radiation, to stimulate the skin contact with microneedle.Thereby medicine can be transported in the skin with remarkable enhancing therapeutic effect.
Description of drawings
To know above and other purpose of the present invention, feature and advantage from the following description of the preferred implementation that provides by reference to the accompanying drawings, in the accompanying drawing:
Fig. 1 is the axonometric chart according to the micro neddle roller assembly of first embodiment of the invention;
Fig. 2 is the exploded perspective view according to the micro neddle roller assembly of first embodiment of the invention;
Fig. 3 is the axonometric chart according to the micro neddle roller assembly of second embodiment of the invention;
Fig. 4 is the exploded perspective view according to the micro neddle roller assembly of second embodiment of the invention;
Fig. 5 is the axonometric chart for the treatment of the pin piece that engages with roller head shown in Figure 4;
Fig. 6 is the axonometric chart of the modification of roller head shown in Figure 4;
Fig. 7 is the axonometric chart according to the micro neddle roller assembly of third embodiment of the invention;
Fig. 8 is the profile of handle component shown in Figure 7;
Fig. 9 is the motor that utilizes in the micro neddle roller assembly according to third embodiment of the invention and vibrates the axonometric chart that member occurs;
Figure 10 is the axonometric chart of micro neddle roller assembly, shows lid and is installed on the roller head shown in Figure 7;
The partial perspective view of Figure 11 state that to be expression lid unload from roller head shown in Figure 10;
Figure 12 and Figure 13 are the axonometric charts of micro neddle roller assembly, show difform lid and are installed on the roller head; And
Figure 14 is the plane graph that is provided with the handle component of infrared generator.
The specific embodiment
According to the preferred embodiment of the present invention micro neddle roller assembly is described with reference to the accompanying drawings in more detail.
The first embodiment
Fig. 1 is the axonometric chart according to the micro neddle roller assembly of first embodiment of the invention, and Fig. 2 is the exploded perspective view according to the micro neddle roller assembly of first embodiment of the invention.
See figures.1.and.2, micro neddle roller assembly 100 (below be called " neddle roller assembly ") comprises roller head 120 and handle component 110.
Externally form a plurality of microneedle 125 (below be called " pin ") on the outer surface of member 121.Preferably, the external member 121 of roller head 120 and pin 125 are integrally formed and made by polymer resin each other, described polymer resin for example comprises the thermosetting resin of epoxy resin, phenolic resins, polyurethane resin, perhaps comprises the thermoplastic resin of PC (Merlon), PEI (Polyetherimide), PMMA (polymethyl methacrylate), POM (polyacetals), PLA (polylactic acid), PSU (polysulfones) etc.
Here, preferably use biodegradable polymers as polymer resin, for example PLA (polylactic acid), PLGA (polylactic acid alkyl acetate multipolymer).Because above material, when pin 125 was stayed in the skin, the pin of being made by above-mentioned material can not damage human body and can decompose at short notice.
Each pin 125 stretches out certain altitude from the outer surface of external member 121.The height of pin 125 can change according to the purposes of micro neddle roller assembly 100.For example, form the passage that arrives skin corium if pin 125 passes epidermis, then the height of pin 125 from 200 μ m in the scope of 750 μ m.Usually, the height of pin 125 determines that from 20 μ m to 2, in the scope of 000 μ m, yet the height of necessary hour hands can exceed above scope.
On the other hand, pin 125 can be partitioned into to arrange with rule and put on the outer surface of member 121 externally.Because above structure can obtain uniform passage and distribute on the specific region of skin.Yet, in order to form a large amount of passages in the specific region of skin by pin 125, expectation be to make the distance between the row who consists of pin 125 on the outer surface of external member 121 narrower in possible limit.
In addition, Fig. 2 illustrates each pin 125 and has cone shape.Yet the shape of pin is not limited to this.
On the other hand, different from roller head shown in Figure 3, roller can only utilize one therein the heart Cylinder shape constructional element that partly forms the tubular space consist of.Yet the roller head volume that inevitably has above structure is larger, so previous materials is subject to very large heat affecting in the forming process of making the roller head.
Consider above-mentioned situation, comprise internals 122, external member 121 and be connected a plurality of support members 123 of two members according to the roller head 120 of this embodiment, therefore the whole volume of roller head reduces greatly, thereby can obviously reduce the distortion that heat causes in the forming process.
Specifically, in the micro neddle roller assembly according to present embodiment, the tubular external member, be formed on that a plurality of pins on the outer surface of tubular external member and internals are made by polymer resin and integrally formed each other, the roller head can form by only carrying out shot forming process.
On the other hand, handle component 110 comprises handle 111 and the first and second linking arms 112 and 113 that extend to both sides from an end of handle.The first and second linking arms 112 and 113 free end are corresponding to the two side ends of the internals 122 of roller head 120.It is outstanding at the inner surface of the free end of the first and second linking arms 112 and 113 respectively to have the stud bump 112A of certain-length and 113A.
In the both side ends in the reception space 124 of the internals 122 that inserts roller head 120 by the stud bump 112A that will form at the inner surface of the free end of the first and second linking arms 112 and 113 and 113A, finished the assembling of handle component 110 and roller head 120.
The diameter of each projection 112A and 113A is less than the diameter in the reception space 124 of internals 122, so each projection 112A and 113A can rotate in the receiving member of internals 122.
On the other hand, hinder projection 112A and 113A after receiving the space by from receiving space 124 taking-ups in order easily to insert with the reception space 124 of projection 112A and 113A insert member 122 and in projection, preferably the first and second linking arms 112 of handle component 110 and 113 are made by having elastic material.
The function according to the neddle roller assembly 100 of this embodiment of structure is as mentioned above described with reference to the accompanying drawings.
As mentioned above, will insert in the both side ends in reception space 124 of internals 122 of roller head 120, with assembled handle member 110 and roller head 120 at the first and second linking arms 112 of handle component 110 and the 113 projection 112A that form and 113A.
Then, user is caught the handle 111 of handle component 110 and the external member 121 of roller head 120 is placed on the skin.At this moment, the percutaneous medicine is coated on the skin.
Under this state, in case user application of force on handle 111, roller head 120 is just around being received in projection 112A and the 113A rotation and mobile at skin that receives in the space 124.
Because the rotation of roller head 120 and mobile at skin, the pin 125 that is formed on the external member 121 penetrates a part of epidermis or the transport path (passage) of whole epidermis to be formed for the percutaneous medicine that consists of skin.In above process, be coated in the passage transdermal that the percutaneous medicine on the skin forms by pin 125.
On the other hand, as mentioned above, if receive therein and the reception space 124 that rotates has cylindrical form for the projection 112A that form at the first and second linking arms 112 and 113 and 113A, then the internals 122 of roller head 120 needn't form cylindrical form.In addition, form along the whole length of internals 122 although above description represents to receive space 124, this space can be formed in each of two ends of internals 122.
The second embodiment
Fig. 3 and Fig. 4 are according to the axonometric chart of the micro neddle roller assembly of second embodiment of the invention and exploded perspective view, show formation according to the structure of each member of the micro neddle roller assembly of second embodiment of the invention.
With reference to Fig. 3 and Fig. 4, micro neddle roller assembly 200 (below be called " neddle roller assembly ") also comprises roller head 220 and handle component 210.
The 26S Proteasome Structure and Function of each element of formation handle component 210 is identical with the 26S Proteasome Structure and Function of each element that consists of handle component 110, therefore omits description of them.
Comprise outside hollow barrel-type member 221 (below be called " external member ") and place the inner hollow member 222 (below be called " internals ") of external member 221 according to the roller head 220 in the neddle roller assembly 200 of present embodiment.Internals 222 is fixed thereon and a plurality of support members 223 of radially extension are supported to external member 221.
External member in external member 221 in the present embodiment and the structure of internals 222 and relation and the first embodiment is identical with relation with the structure of internals, so omits description of them.
In addition, at the outer surface of the external member 221 of roller head 220 a plurality of pin pieces 230 are installed.Specifically describe the structure of roller head 200 and pin piece referring to Fig. 4 and Fig. 5.
As shown in Figure 4, roller head 220 comprises outside hollow barrel-type member 221 and inner hollow member 222, externally forms a plurality of groove 221-1 with certain-length on the outer surface of member 121.The both ends open of each groove 221-1, the width on each groove top is less than the width of bottom.
Fig. 5 is the axonometric chart that is installed to the pin piece 230 on the roller head 220.
Here, preferably use biodegradable polymer as polymer resin, for example PLA (polylactic acid), PLGA (polylactic acid alkyl acetate multipolymer).Because above material, if the pin 225 that separates with pin piece 230 is stayed in the skin, the pin of then being made by above-mentioned material can not damage human body and can decompose at short notice.
Each pin 225 stretches out certain altitude from the outer surface of pin piece 230.The height of pin 225 can change according to the purposes of micro neddle roller assembly 200.For example, form the passage that arrives skin corium if pin 225 passes epidermis, then the height of pin 225 from 200 μ m in the scope of 750 μ m.Usually, the height of pin 225 determines that from 20 μ m to 2, in the scope of 000 μ m, yet the height of necessary hour hands can exceed above scope.
Here, pin 225 can be arranged on the pin piece 230 with regular interval.Because above structure can obtain uniform passage and distribute in the specific region of skin.Yet, in order to form a large amount of passages in the specific region of skin by pin 225, expectation be to make on the pin piece 230 distance between the pin 225 narrower.In addition, Fig. 5 represents that each pin 225 has cone shape.Yet the shape of pin is not limited to this.
As shown in Figure 4, on the other hand, side cover 240 and 250 is installed to the both sides of external member 221, is used for preventing that pin piece 230 is along the axial separation of external member 221.Side cover 240 is identical with the diameter of external member 221 with 250 diameter.
In case side cover 240 and 250 is fixed to the both sides of external member 221, just expose by the opening 241 and 251 that is formed on side cover 240 and 250 middle bodies two ends of internals 224, and two opening sides of each groove 221-1 correspond respectively to side cover 240 and 250.Under this state, by side cover 240 or 250 the pin piece 230 that is received among the groove 221-1 can not be separated with groove.
Assembling process and function according to the neddle roller assembly 200 of this embodiment are described with reference to the accompanying drawings.
At first, by promoting pin piece 230 with among the opening slip insertion groove 221-1 of each pin piece 230 by corresponding groove 221-1, then in all pin piece insertion grooves, afterwards side cover 240 and 250 is respectively fixed to the both side ends of external member 221.
Under this state, be formed in two ends of exposing side cover 240 and 250 in reception space 224 of the internals 222 that projection 212A on first and second linking arms 212 and 213 of Handleset 210 and 213A insert roller head 120, with assembled handle member 210 and roller head 220.
Afterwards, user is caught the handle 211 of handle component 210 and the external member 221 of roller head 220 is placed on the skin.Under this state, in case user application of force on handle 211, external member 221 will be around being received in projection 212A and the 213A rotation and mobile at skin that receives in the space 224.
Process subsequently and function are identical with neddle roller assembly 100 according to the first embodiment, therefore omit its detailed description.
On the other hand, be fixed in the situation of a side end of external member 221 the open end slip insertion groove 221-1 of the fixedly side cover that pin piece 230 can be by groove 221-1 at side cover only (for example 250).Then, another side cover (for example 240) can be fixed to the other end of external member 221 to finish the assembling of roller head.
Fig. 6 is the axonometric chart of the modification of roller head shown in Figure 4.Different from the roller head 220 that comprises as shown in Figure 4 external member 221 and internals 222, the single Cylinder shape constructional element 221A that partly is formed with in the central axial penetrating via 224A can be used as roller head 220A.
Be used as in the situation of roller head 220A at single Cylinder shape constructional element 221A, at a plurality of groove 221A-1 of outer surface formation of Cylinder shape constructional element 221A.
At this moment, form although groove 221A-1 can be parallel to the axis of Cylinder shape constructional element 221A, each groove 221A-1 can be with respect to the axis inclination certain angle of Cylinder shape constructional element 221A, as shown in Figure 6.Pin piece 230 is installed on the roller head 220A with structure as mentioned above.
On the other hand, in having the roller head 220A of structure shown in Figure 6, because the crooked outer surface of Cylinder shape constructional element 221A, has longitudinal cross-section shape along its whole length rounding with respect to the groove 221A-1 of the axis inclination certain angle of Cylinder shape constructional element 221A.Yet as mentioned above, because pin piece 230 made by flexible resin material, so although groove 221A-1 has arbitrary shape, have elastic pin piece 230 and still can insert swimmingly and be received among the groove 221A-1.
Here, in roller head 220 shown in Figure 4, owing to pin piece 230 is arranged on the external member 221 with regular interval, so the row of pin 225 also arranges with regular interval.Yet in having the roller head 220A of structure shown in Figure 6, each pin piece 230 is in tilted layout with respect to the axis of Cylinder shape constructional element 221A, so that pin 225 is arranged on the roller head 220A brokenly.
Because the above layout of pin, thus in the pin on being formed at same pin piece 230, some pin transdermals, remaining pin is transdermal not.Thereby thereby can between pin piece and skin, not produce larger resistance roller head 220A can smooth and easy rotation.
On the other hand, although not shown in the drawings, side cover 240 and 250 shown in Figure 4 is fixed to the both sides of roller head 220A to be separated with roller head 220A to prevent pin piece 230.
The 3rd embodiment
Micro neddle roller assembly according to third embodiment of the invention (below be called " neddle roller assembly ") is described below.
Fig. 7 is the axonometric chart according to the neddle roller assembly of third embodiment of the invention, also comprises roller head 320 and handle component 310 according to the neddle roller assembly 300 of third embodiment of the invention.
Therefore the 26S Proteasome Structure and Function of this embodiment central roll head 320 omits the description to it with identical according to the 26S Proteasome Structure and Function of the roller head 220 of the second embodiment and 220A.
In addition, the 26S Proteasome Structure and Function that is installed in this embodiment the pin 325 on the roller head 320 with according to the neddle roller assembly 100 of the first and second embodiments and 200 be installed to roller head 120,220 and 220A on pin 125 and 225 26S Proteasome Structure and Function identical, therefore omit description of them.
To apply vibration to the roller head 320 with contact skin with the structure of the ability that strengthens transdermal according to the principal character of the neddle roller assembly 300 of third embodiment of the invention.
Be described in more detail below the neddle roller assembly 300 with above function.
Fig. 8 is the profile of handle component 310 shown in Figure 7, and handle component 310 comprises handle 311 and the first and second linking arms 312 and 313 that extend to both sides from an end of handle 311.The first and second linking arms 312 and 313 free end are corresponding to the two side ends of roller head 320.Have the stud bump 312A of certain-length and 313A (shown in Figure 14) respectively outstanding formation of inner surface of the free end of the first and second linking arms 312 and 313.
As shown in Figure 8, the end of handle 311, namely the part near the first and second linking arms 312 and 313 is inclined upwardly, and forms the recess 311-1 with certain depth at this sloping portion.When user used neddle roller assembly 300, the finger of user placed the recess 311-1 that is formed on handle 311 leading sections, so that user can be stably to handle 311 application of forces.
As shown in Figure 8, in handle 311, can form the space 311-2 with certain volume, in the 311-2 of this space, hold vibration generating arrangement 330, circuit part 340 and power supply 350.The 26S Proteasome Structure and Function of vibration generating arrangement, circuit part and power supply is described below.
Fig. 9 is the figure that consists of according to the vibration generating arrangement of the neddle roller assembly of third embodiment of the invention, and vibration generating arrangement 330 comprises CD-ROM drive motor 331 and eccentric weight 333.
As shown in Figure 9, the connecting hole 333-1 for the driving shaft 331-1 that inserts CD-ROM drive motor 331 of eccentric weight 333 is amesiality, therefore produces vibration when eccentric weight 333 is rotated along with the driving of CD-ROM drive motor 331.
The vibration that eccentric weight 333 produces is delivered to the roller head 320 that is connected with handle 311 by the first and second linking arms 312 with being connected.Thereby transfer of vibration is to the pin 325 that is installed on the roller head 320, so that pin 325 easily pierces through skin.Therefore, medicine transdermal effectively.
In addition, pin 325 chafes of vibration are with the activation skin histology and accelerate blood circulation, so the medicine of transdermal can spread effectively.
The circuit part 340 that is arranged among the space 311-2 of handle 311 is electrically connected to CD-ROM drive motor 331, and the switch 341 (for example, slide switch) that is connected to circuit part 340 is slidably mounted on the outer surface of handle 311.Thereby, according to the motion of switch 341, flow to the flow of electrical power of the CD-ROM drive motor 331 of vibration generating arrangement 330 by circuit part's 340 controls.
Power supply 350 (for example battery) is arranged among the space 311-2 of handle 311, and this power supply 350 is electrically connected to circuit part 340.According to the operation of above-mentioned switch 341, the electric power of power supply 350 is applied to the CD-ROM drive motor 331 of vibration generating arrangement 330 by circuit part 340.
On the other hand, the neddle roller assembly 300 according to third embodiment of the invention also can comprise the light emitting diode (LED) 360 that is arranged on handle 311 outer surfaces.For example, LED 360 in series is electrically connected to circuit part 340 and CD-ROM drive motor 331.In case electric power is applied to CD-ROM drive motor 331 by circuit part 340, LED 360 is just luminous, so user can be fed to CD-ROM drive motor 331 from visually confirming electric power.
Figure 10 is the axonometric chart of neddle roller assembly, shows to cover 380 and be installed on the roller head 320 shown in Figure 7, and Figure 11 is the partial perspective view that 380 states that unload from roller head 320 shown in Figure 10 are covered in expression.
As mentioned above, when 320 pairs of skins of the roller head that pin 325 is installed were exerted pressure and be mobile, blood can spray from the passage that pin 325 forms.The lid 380 anti-Hemostatic Oral Liquids that are arranged on the roller head 320 spatter to the outside.
As shown in the figure, lid 380 comprise hollow semicircular cylinder sheet 382, the extension 384 that extends from sheet 382 and the bool 386 that is formed on extension 384 rearward end.The width of sheet 382 is identical with the width of roller head 320.
On the other hand, form the slit 311-3 with one fixed width in the front portion of handle 311 close the first and second linking arms 312 and 313, the bool 386 of lid 380 is inserted among this slit 311-3.Thereby, lid 380 hollow semicircular cylinder sheet 382 cover roller heads 320 except corresponding to the part the downside of user skin.
Figure 12 is the axonometric chart of microneedle assembly, shows to cover 380A and be installed on the roller head 320.
Figure 13 is the axonometric chart of microneedle assembly, shows to cover 380B and be installed on the roller head 320.Lid 380B shown in Figure 13 also comprises hollow semicircular cylinder sheet 382B, the extension 384B that extends from sheet 382B and the bool (not shown) that is formed on extension 384B rearward end.
A plurality of hook 388B with certain-length are fixed to the both sides of sheet 382B, and hook 388B joins the first and second linking arms 312 (in Figure 13, only showing a hook 388B and a linking arm 312) to.
Hook 388B prevents that the sheet 382B that covers 380B from contacting with roller head 320, so roller head 320 can smooth and easy rotation and movement and not stopped by any of sheet 382B.
On the other hand, can form respectively the groove (not shown) with certain depth on the upper surface of the first and second linking arms 312, each of these grooves is corresponding to each hook.As lid 380B when joining roller head 320 to, hook 388B is received in respectively in the groove on the upper surface that is formed at the first and second linking arms 312, so hook 388B can not separate with the first and second linking arms 312.Thereby lid 380B stably places on the roller head 320.
Preferably, above-mentioned lid 380,380A and 380B are made by transparent material, make user ooze out from visually confirming the passage whether blood forms from pin.Merlon (PC), polyethylene terephthalate (PET), polymethyl methacrylate (PMMA) etc. can be used as and cover 380, the material of 380A and 380B.And this lid can be integrally formed with handle.
On the other hand, also can comprise at least one infrared generator according to neddle roller assembly of the present invention.Figure 14 is the plane graph that is provided with the handle component of infrared generator.For convenient, not shown roller head in Figure 14.
Be incorporated into the first and second linking arms 312 on the roller head (Fig. 7 to Figure 13 320) and 313 inner surface arranges infrared generator 392 and 393 waiting, infrared generator 392 and 393 is electrically connected to power supply 350 by foregoing circuit section 340.
Here, circuit part 340, vibration generating arrangement 350 and infrared generator 392 and 393 sequentially are electrically connected to each other, circuit part 340 is connected to vibration generating arrangement 350 by switch, therefore can control simultaneously by the operation of switch (that is, connecting/cut off) vibration generating arrangement 350 and infrared generator 392 and 393.
Preferably utilizing radiation wavelength is that the infrared generator of the above far infrared of 25 μ m is as infrared generator 392 and 393.As known in the art, far infrared has the heat effect of forcing and strong penetrating power, therefore can obtain good hot compress effect to blood circulation by means of far infrared.In addition, because far infrared, but softening skin, thus stimulate the skin that contacts with pin and be coated in medicine transdermal easily on the skin.
Usually, from far-infrared radiation material more far infrared of radiation under hot conditions that infrared generator 392 and 393 is emitted, therefore expectation is infrared generator to be heated to 40 to 50 ℃ temperature, then radiation infrared.
When the temperature radiation far infrared more than 50 ℃, should understand the skin of the user of may burning.Therefore, preferred set temperature detection sensor (not shown) is controlled at below the predetermined value with the temperature with far infrared.
Although described a plurality of embodiments with reference to a plurality of illustrative embodiments, should understand those skilled in the art and can in the spirit and scope of disclosure principle, design a plurality of other modifications and embodiment.More particularly, in the scope of the disclosure, accompanying drawing and claims, can carry out various changes and modification to component parts and/or the layout of subject combination structure.Except the change and modification of component parts and/or layout, substituting purposes also is apparent to those skilled in the art.
Industrial applicibility
Because all structural elements, be the tubular external member, be formed on a plurality of pins on the external member outer surface and join that internals on the external member is made by polymer resin to and integrally formed each other by support member, so can only simply make by shot forming process according to micro neddle roller assembly of the present invention.
In addition, in micro neddle roller assembly according to the present invention, the pin piece that is formed with microneedle on roller head and its is separately made, then each other assembling.Therefore,, after the roller head unloads, can then new pin piece be installed on the roller head, thereby can reuse roller head and handle component at the pin piece of crossing with the user contact skin.
In addition, can on the pin piece, form respectively the different a plurality of pins of size (diameter and height), therefore user can have based on the body part selection of drug variety, drug dose and coating medicine the pin piece of the pin of desired size, then selected pin piece is installed to the roller head.
Specifically, owing to according to micro neddle roller assembly involving vibrations generating means of the present invention, so microneedle pierces through skin effectively owing to be delivered to the vibration of roller head, thereby improve the drug delivery effect, activate skin histology and can accelerate blood circulation.
In addition, when microneedle pierced through skin, the lid that the blood that the passage that forms from pin spills is placed on the roller head stopped, so user can wholesomely use micro neddle roller assembly.
Specifically, but by the infrared ray softening skin from the infrared generator radiation, to stimulate the skin contact with microneedle.Thereby medicine can be transported in the skin with remarkable enhancing therapeutic effect.
Claims (20)
1. micro neddle roller assembly, this micro neddle roller assembly comprises:
The roller head, this roller head comprises the tubular external member, be formed with a plurality of microneedle on the surface of described external member, this roller head also comprises the internals that is positioned at described external member, the reception space that described internals has two ends and forms at each place, described end, and described roller head also comprises a plurality of support members, these support members are fixed to described external member with described internals and reduce the overall volume of described roller head, described microneedle, the described external member of tubular, described internals and described support member are integrally formed and made by polymer resin each other; And
Handle component, this handle component joins described internals to, be used for making the described internals rotation of described roller head, described handle component comprises handle and the first linking arm and the second linking arm that extend from described handle, each described linking arm includes the projection that is formed on its inner surface, and described projection is received in the corresponding reception space of described internals of described roller head.
2. micro neddle roller assembly according to claim 1, wherein, described internals is the hollow barrel-type member, described support member is along the radially extension of described internals.
3. micro neddle roller assembly according to claim 1, wherein, described reception space is tubular.
4. micro neddle roller assembly according to claim 1, wherein, the length of described support member is identical with the length of described external member, thereby prevents described external member distortion.
5. micro neddle roller assembly according to claim 1, wherein, polymer resin is a kind of in thermosetting resin and the thermoplastic resin.
6. micro neddle roller assembly according to claim 1, wherein, polymer resin is biodegradable polymers.
7. micro neddle roller assembly, this micro neddle roller assembly comprises:
The roller head, this roller head comprises the tubular external member, described external member is equipped with a plurality of microneedle pieces in its surface, all be formed with a plurality of microneedle on each microneedle piece, the described external member of described roller head also is formed with groove on described surface, each microneedle piece all is received in each groove, described roller head also comprises the internals that is arranged in described external member, the reception space that described internals has two ends and forms at each place, described end, and described roller head also comprises a plurality of support members, these support members are fixed to described external member with described internals and reduce the overall volume of described roller head, the described external member of tubular, described support member and described internals are integrally formed and made by polymer resin each other; And
Handle component, this handle component joins described internals to, be used for making the described internals rotation of described roller head, described handle component comprises handle and the first linking arm and the second linking arm that extend from described handle, each described linking arm includes the projection that is formed on its inner surface, and described projection is received in the corresponding reception space of described internals of described roller head.
8. micro neddle roller assembly according to claim 7, wherein, described groove is along the longitudinal extension of described external member, and has top and width greater than the bottom on described top, and the cross sectional shape of described pin piece is identical with the cross sectional shape of described groove.
9. micro neddle roller assembly according to claim 7, wherein, described pin is made by the material identical with the material of making described external member with described pin piece.
10. micro neddle roller assembly according to claim 8, wherein, the axis that described groove is parallel to described tubular external member forms.
11. micro neddle roller assembly according to claim 8, wherein, described groove tilts at a certain angle with respect to the axis of described tubular external member.
12. each described micro neddle roller assembly in 11 according to claim 7, this micro neddle roller assembly also comprises the side cover that is fixed to described roller head two side ends, and each side cover has the opening corresponding with described internals.
13. micro neddle roller assembly according to claim 1, this micro neddle roller assembly also comprise vibration generating arrangement and power supply in the space in the described handle that is received in described handle component.
14. micro neddle roller assembly according to claim 13, wherein, described vibration generating arrangement comprises the CD-ROM drive motor that is electrically connected to described power supply and the eccentric weight that joins the driving shaft of described CD-ROM drive motor to.
15. micro neddle roller assembly according to claim 13, this micro neddle roller assembly also comprises be used to the switch of controlling the electrical connection between described vibration generating arrangement and the power supply.
16. micro neddle roller assembly according to claim 15, this micro neddle roller assembly also comprises at least one infrared generator, this infrared generator is connected to described power supply by described switch, and is arranged at least one the inner surface in described the first linking arm and described the second linking arm.
17. micro neddle roller assembly according to claim 1, wherein, described handle is formed with recess on its surface near described the first linking arm and described the second linking arm.
Be fixed to described handle and place lid on the described roller head 18. micro neddle roller assembly according to claim 1, this micro neddle roller assembly also comprise.
19. micro neddle roller assembly according to claim 18, wherein, described handle is formed with slit at its a part of place, and described lid comprises hollow semicircular cylinder sheet, from the extension of described extension and be formed on an end of described extension and insert bool in the described slit of described handle.
20. micro neddle roller assembly according to claim 19, wherein, described width of described lid is identical with the width of described roller head.
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020060061787 | 2006-07-03 | ||
| KR10-2006-0061788 | 2006-07-03 | ||
| KR1020060061788A KR100792382B1 (en) | 2006-07-03 | 2006-07-03 | A micro needle roller and forming mold thereof |
| KR10-2006-0061787 | 2006-07-03 | ||
| KR1020060061787A KR100753872B1 (en) | 2006-07-03 | 2006-07-03 | A micro needle roller and manufacturing method thereof |
| KR1020060061788 | 2006-07-03 | ||
| KR10-2007-0013559 | 2007-02-09 | ||
| KR1020070013559 | 2007-02-09 | ||
| KR1020070013559A KR100941770B1 (en) | 2007-02-09 | 2007-02-09 | Micro needle roller |
| PCT/KR2007/003121 WO2008004781A1 (en) | 2006-07-03 | 2007-06-27 | Micro neddle roller assembly |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101472642A CN101472642A (en) | 2009-07-01 |
| CN101472642B true CN101472642B (en) | 2013-04-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800226769A Active CN101472642B (en) | 2006-07-03 | 2007-06-27 | Micro neddle roller assembly |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR100792382B1 (en) |
| CN (1) | CN101472642B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR200453182Y1 (en) | 2008-05-01 | 2011-04-15 | 김기태 | Skin care device for electric treatment |
| CN101904796A (en) * | 2010-07-05 | 2010-12-08 | 苏州工业园区博友钛钢科技有限公司 | Vibratory massage stick |
| JP5677013B2 (en) | 2010-10-14 | 2015-02-25 | Ntn株式会社 | Beauty / health roller bearing device and beauty / health roller |
| CN105999536B (en) * | 2016-05-09 | 2019-01-18 | 上海交通大学 | Synchronous injection skin needle roller |
| KR102178324B1 (en) * | 2018-06-26 | 2020-11-13 | 주식회사 정우티앤씨 | A Micro-needle Roller |
| KR102175310B1 (en) | 2018-08-28 | 2020-11-06 | 연세대학교 산학협력단 | Shooting microstructures and Applicator for the same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4011622A (en) * | 1975-10-14 | 1977-03-15 | Kagil Corporation | Attachment for a roller applicator |
| US4625366A (en) * | 1984-10-18 | 1986-12-02 | Staedtler & Uhl. | Opening cylinder for open-end spinning machines or the like |
| US6334856B1 (en) * | 1998-06-10 | 2002-01-01 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10063634B4 (en) * | 2000-12-20 | 2006-01-12 | Liebl, Horst, Zelsheim | Device and method for introducing an active substance into the skin |
| JP2007523771A (en) * | 2004-02-23 | 2007-08-23 | スリーエム イノベイティブ プロパティズ カンパニー | Microneedle array molding method |
| KR200395359Y1 (en) * | 2005-06-27 | 2005-09-08 | (주)클리니칼레졸루션아시아 | Microneedle Roller |
-
2006
- 2006-07-03 KR KR1020060061788A patent/KR100792382B1/en active IP Right Grant
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2007
- 2007-06-27 CN CN2007800226769A patent/CN101472642B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4011622A (en) * | 1975-10-14 | 1977-03-15 | Kagil Corporation | Attachment for a roller applicator |
| US4625366A (en) * | 1984-10-18 | 1986-12-02 | Staedtler & Uhl. | Opening cylinder for open-end spinning machines or the like |
| US6334856B1 (en) * | 1998-06-10 | 2002-01-01 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100792382B1 (en) | 2008-01-08 |
| CN101472642A (en) | 2009-07-01 |
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Address after: Seoul, Korea Applicant after: Lotte Chemical Corporation Applicant after: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY Address before: Seoul, Korea Applicant before: Hunan Petrochemical Corporation Applicant before: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
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