CN101548184A - Biochip reader - Google Patents

Biochip reader Download PDF

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Publication number
CN101548184A
CN101548184A CNA2007800449409A CN200780044940A CN101548184A CN 101548184 A CN101548184 A CN 101548184A CN A2007800449409 A CNA2007800449409 A CN A2007800449409A CN 200780044940 A CN200780044940 A CN 200780044940A CN 101548184 A CN101548184 A CN 101548184A
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CN
China
Prior art keywords
reader
analyzer
transmitting set
analysis result
optical transmitting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA2007800449409A
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Chinese (zh)
Other versions
CN101548184B (en
Inventor
李大植
孙美进
郑光孝
表铉奉
朴善熙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Electronics and Telecommunications Research Institute ETRI
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Electronics and Telecommunications Research Institute ETRI
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Publication date
Application filed by Electronics and Telecommunications Research Institute ETRI filed Critical Electronics and Telecommunications Research Institute ETRI
Priority claimed from PCT/KR2007/006257 external-priority patent/WO2008069554A1/en
Publication of CN101548184A publication Critical patent/CN101548184A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00722Communications; Identification
    • G01N35/00871Communications between instruments or with remote terminals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00722Communications; Identification
    • G01N35/00732Identification of carriers, materials or components in automatic analysers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00158Elements containing microarrays, i.e. "biochip"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00722Communications; Identification
    • G01N35/00732Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742Type of codes

Abstract

Provided is a biochip reader which can analyze an optical detection result obtained from a biochip or strip chip, and transmit and receive the analysis result in a bio-microelectromechanical system (bio-MEMS) field. The reader for reading a target chip inserted thereinto includes: a light emitter including a three-color light emitting elements; a light receiver configured to receive light generated in the light emitter, reflected or refracted by the target chip, or transmitted through the target chip, and convert the received light into an electric signal; an analyzer configured to drive the light emitter in a switching manner when the target chip is inserted, and analyze the electric signal transmitted from the light emitter; a storage unit configured to store a program to be executed by the analyzer and temporarily store an analysis result outputted from the analyzer; and a display unit configured to display the analysis result.

Description

Biochip reader
Technical field
The present invention relates to biochip reader; And more specifically, relate to optical detection result that analyzing in biological MEMS (micro electro mechanical system) (bio-MEMS) field obtain from biochip or strip chip, and transmit and receiving and analyzing result's biochip reader.
This work obtains the IT R﹠amp of MIC/IITA; The support [2006-S-007-01, " UbiquitousHealth Monitoring Module and System Development "] of D planning.
Background technology
One of typical strip chips is to be used to detect women's pregnancy or the strip chip of ovulating.Because strip chip shows testing result, so the user can visually detect pregnancy or ovulation.The user can use strip chip easily, and need not independent servicing unit.Yet, for example use that the strip chip of the porous plate of nitrocellulose has the shortcoming that its precision may be low, because it has the sensing range that is difficult to visually verify as the color pattern of testing result output.In addition, but because do not have stored pattern so that use test result's method, so in the application of strip chip, there is restriction.
As another example, reader is to be used to read for example device of the optical pattern result of the strip chip analysis of the light of visual ray of use transmissive (transmit).
Exist many documents to disclose, but have the strip chip of fillet plate that can transmitted light, directly or indirectly detect the analyzer that the transparent type light of the test material within the detection zone detects reader and uses with reader.The comparable visual inspection of such reader is analysis chip more accurately.Yet, when reading weak pattern, owing to the refraction of light has reduced precision.Be or do not using this reader in the type analysis.Reader needs independent device to store or transmit this analysis.
Recent years is for can be at any time and check Anywhere and monitor that there are the demand that increases in ordinary people's new analysis of health status and reader.And, there is the demand that increases for the method for the restriction that can overcome prior art.
For this reason, proposed to use the reader of optical transmitting set, optical receiver and microprocessor.
These conventional reader use single white light source as photocell.In this case, because the signal to noise ratio (snr) height, so when signal that microprocessor analysis detected, accuracy of detection is lowered about detection threshold.
Summary of the invention
Technical matters
Embodiments of the invention aim to provide a kind of by using three coloured light can obtain the reader of more accurate optical detection result from biochip or strip chip in the bio-MEMS field.
Another embodiment of the present invention aim to provide a kind of can be at any time and transmit analysis result or receive the biochip reader of data to remote site Anywhere.
Other purposes of the present invention and advantage can be understood by following description, and can become clear by the reference embodiments of the invention.And, for those skilled in the art of the present invention, it is evident that, can realize objects and advantages of the present invention by claimed means and combination thereof.
Technical scheme
According to an aspect of the present invention, provide a kind of reader that is used to read insertion objective chip wherein, this reader comprises: optical transmitting set comprises three coloured light radiated elements; Optical receiver, be configured to be received in this optical transmitting set generate, by this objective chip reflection or refraction or transmission light by this objective chip, and the light that will receive is transformed to electric signal; Analyzer is configured to drive this optical transmitting set according to switching mode when inserting this objective chip, and analyzes the electric signal that transmits from this optical transmitting set; Storage unit, being configured to store will be by the program of this analyzer operation, and temporary transient storage is from the analysis result of this analyzer output; And display unit, be configured to show this analysis result.
According to an aspect of the present invention, provide a kind of reader that is used to read insertion objective chip wherein, this reader comprises: optical transmitting set comprises three coloured light radiated elements; Optical receiver, be configured to be received in this optical transmitting set generate, by this objective chip reflection or refraction or transmission light by this objective chip, and the light that will receive is transformed to electric signal; Analyzer is configured to drive this optical transmitting set according to switching mode when inserting this objective chip, and analyzes the electric signal that transmits from this optical transmitting set; Storage unit, being configured to store will be by the program of this analyzer operation, and temporary transient storage is from the analysis result of this analyzer output; Display unit is configured to show this analysis result; Communication module is configured to transmit this analysis result to remote terminal; And side wall, be installed between this optical transmitting set and this optical receiver, with the interference that prevents to cause by the light that generates from this optical transmitting set.
Advantageous effects
Reader according to the embodiment of the invention can provide more accurate testing result by using the color and the light intensity of three-color light source analysis reflection.In addition, by using RFID chip and wireless communication module, reader can be at any time and inventory analysis result Anywhere, and it is sent to the place of expectation in real time.This reader can be extensive use of by expert or ordinary people in first-aid room, private hospital and family.
Description of drawings
Fig. 1 is the block diagram of reader according to an embodiment of the invention.
Fig. 2 illustrates the structure of reader according to an embodiment of the invention.
Fig. 3 illustrates optical transmitting set and optical receiver according to an embodiment of the invention.
Embodiment
By the following description of with reference to the accompanying drawings embodiment being carried out of elucidated hereinafter, it is clear that advantage of the present invention, feature and aspect will become.So those skilled in the art of the present invention can easily implement technological concept of the present invention and scope.In addition, then will not provide detailed description here by each point fuzziness of the present invention if think that detailed description for prior art can make.Describe the preferred embodiments of the present invention below with reference to the accompanying drawings in detail.
Comparable visual test provides the analysis result of more accurate biochip or strip chip according to the reader of the embodiment of the invention, and can transmit analysis result to hospital or doctor's terminal.So, can be fast and accurately to the optical information amount of carrying out of the biochip that detects and the analysis of matter, and the user can know analysis result concisely.In addition, because reader can transmit private medical information to particular hospital or doctor's terminal with the wireless communication module combination, so can easily carry out health care in the ubiquitous environment in future.The example of the target biomaterial of biochip comprises the biological marker relevant with cancer, hormone, the body fluid of representing for example blood of personal health state, the Causative virus of for example bird flu and the medication that adds up (additive drugs) of being correlated with pregnancy or ovulation.
Fig. 1 is the block diagram of reader according to an embodiment of the invention, and Fig. 2 illustrates the details drawing of the structure of reader according to an embodiment of the invention.
With reference to figure 1, biochip reader comprises optical transmitting set 101, optical receiver 102, amplifier 103, A-D converter (ADC) 104, micro-control unit (MCU) 105, storer 106 and LCD (LCD) 107.Optical transmitting set 101 realized by three-color light source, and optical receiver 102 receives from optical transmitting set 101 and generates and then by biochip reflection or refraction or by the light of transmission by biochip.Amplifier 103 amplifies the electric signal that is received by optical receiver 102.ADC 104 is transformed to digital signal with amplifying signal.MCU 105 analyzes from the digital signal of ADC 104 outputs.Storer 106 storage will be by the program of MCU 105 operations, and the data that read of temporary transient store M CU 105, and LCD 107 serves as the display unit that is used to show from the analytical information of MCU 105 outputs.
In addition, the biochip reader according to the embodiment of the invention also can comprise communication module 108 and fluid control module.Communication module 108 transmits the result that MCU 105 is read to remote site.Fluid control module moves in biochip, stops and mixing microfluid, is used for effective analysis.Side wall 202 can be installed between optical transmitting set 101 and the optical receiver 102, detects with effective execution light.
With reference to figure 3, the optical transmitting set 101 of biochip reader comprises the combination of redness, green and blue LED (LED).
When using single white light source, the signal to noise ratio (snr) height, and when the 105 analysis light time that optical receiver received of MCU, accuracy of detection is lowered about detection threshold.In order to address these problems, realize optical transmitting set 101 with the combination of three-color light source 301 to 303.According to this mode, can significantly reduce SNR.In addition, when use is suitable for the light receiving diode of each wavelength or transistor, analytical wavelengths and brightness simultaneously.Thus, improved accuracy, and the analysis result of biochip 201 is read in available more accurate expression.Can control three look IED of optical transmitting set 101 according to switching mode intermittently.
Optical receiver 102 can comprise the typical silicon sensor assembly of silicon photoelectric diode for example or phototriode.By arranging sensor, can guarantee the susceptibility and simple installation of biochip according to array format.
Because the side wall of installing between optical transmitting set 101 and optical receiver 102 202 so prevent to be directly delivered to optical receiver 102 from the light of optical transmitting set 101 emissions, improves the precision that light detects thus.
In addition, biochip reader comprises fluid control module, is used for moving in biochip, stops and mixes microfluid, is used for effective analysis.This fluid control module comprises fluid passage (passage), and is removable, mix and stop for example solution of damping fluid (buffer), body fluid or blood by this passage, is used for the simple analysis of biological specimen.This fluid control module comprises the storage tank 203, the pump 204 that is used to transmit fluid that are used for storing fluid, be used to control the valve 205 and the fluid control mixer 206 of the transmission of fluid.Can use for example electrostatic motor, piezoelectric pump, hydraulic pressure or Pneumatic pressure or hyperacoustic various driving method, be used to move, stop and fluid-mixing.
Use description in reader, install the processing of strip chip or biochip 201 below.
Use for example control lever of installing in the reader of the elastomeric element of spring (lever) that has, insert strip chip or biochip 201.When strip chip or biochip 201 arrival precalculated positions, the groove that forms in its suitable control lever.The chip fit structure is installed on the biochip and with the spring of reader and links to each other.Because this chip fit structure is so can analyze biochip under the situation that does not have exterior vibration or shake.
In addition, separable (detachable) control lever is installed, is used for the simple separation of biochip or adheres to.Detachable lever is connected to inclination (tilting) spring.In addition, can use the additional structure of similar clip to force fit on molding box (top case) and nowel (bottom case), maybe can come fit on molding box and nowel by in one of two chests, forming excrescence and in another, forming groove.When fit on molding box and nowel, elastomeric polymer layer can further be added, on surface in contact so that prevent the formation of fine gap.
Adhere to and the separable structure of reader and biochip only are examples, and can easily be realized by those skilled in the art, and therefore will omit its detailed description.
Reader can comprise that it can communicate according to wireless mode and mobile communications network as the mobile communication modulator-demodular unit of communication.In this case, MCU 105 creates analysis result according to format, and sends it to the mobile communication modulator-demodular unit.The mobile communication modulator-demodular unit is sent to the remote terminal that the user selects by wireless data communications with analysis result.
Reader can comprise radio-frequency (RF) identification (RFID) chip as communication module.In this case, MCU105 record analysis result in the RFID chip.When the user was intended to remote terminal transmission analysis result, the wired/wireless terminal with RFID reader read analysis result and sends it to remote terminal from the RFID chip.
The operation that below description is had the reader of said structure.
When in reader, inserting biochip 201, switch connection, and biochip is inserted signal be input to MCU 105.MCU 105 determines to have inserted biochip 201 in reader, and supply electric power, is used to drive the optical transmitting set of realizing with three-color LED 101.In this point, MCU 105 according to switching mode to the three-color LED discontinuous power supply.
Light is from optical transmitting set 101 output, and by biochip 201 reflections or refraction or by transmission by biochip 201, and receive by optical receiver 102 then.Optical receiver 102 is transformed to electric signal with the optical signalling that receives.Amplifier 103 amplifies from the electric signal of optical receiver 102 outputs, and ADC104 is transformed to digital signal with amplifying signal, and sends it to MCU 105.MCU 105 analyzes these digital signals, and on LCD 107 the display analysis result.
MCU 105 can be in the RFID chip record analysis result or send it to remote terminal by the mobile communication modulator-demodular unit.
Although described the present invention at some preferred embodiment, it will be apparent to one skilled in the art that and can carry out various changes and modification, and the scope of the present invention that does not break away from following claim and limited.

Claims (14)

1. a reader is used to read insertion objective chip wherein, and this reader comprises:
Optical transmitting set comprises three coloured light radiated elements;
Optical receiver, be configured to be received in this optical transmitting set generate, by this objective chip reflection or refraction or transmission light by this objective chip, and the light that will receive is transformed to electric signal;
Analyzer is configured to drive this optical transmitting set according to switching mode when inserting this objective chip, and analyzes the electric signal that transmits from this optical transmitting set;
Storage unit, being configured to store will be by the program of this analyzer operation, and temporary transient storage is from the analysis result of this analyzer output; With
Display unit is configured to show this analysis result.
2. according to the reader of claim 1, also comprise:
Communication module is configured to transmit this analysis result to remote terminal.
3. according to the reader of claim 2, wherein this optical transmitting set comprises the combination of red diode, green diode and blue diode, and
This analyzer comes the described red diode of intermittent controlled, green diode and blue diode according to switching mode.
4. according to the reader of claim 3, wherein this optical transmitting set also comprises:
Be used to proofread and correct the detecting device of light emission measure and the light source between the controller.
5. according to the reader of claim 3, wherein this communication module comprises radio-frequency (RF) identification (RFID) chip that links to each other with analyzer.
6. according to the reader of claim 4, this analyzer record analysis result in this RFID chip wherein.
7. according to the reader of claim 3, wherein this communication module comprises the mobile communication modulator-demodular unit, is configured to communicate by letter with this analyzer, and transmits this analysis result by mobile communications network to this remote terminal.
8. a reader is used to read insertion objective chip wherein, and this reader comprises:
Optical transmitting set comprises three coloured light radiated elements;
Optical receiver, be configured to be received in this optical transmitting set generate, by this objective chip reflection or refraction or transmission light by this objective chip, and the light that will receive is transformed to electric signal;
Analyzer is configured to drive this optical transmitting set according to switching mode when inserting this objective chip, and analyzes the electric signal that transmits from this optical transmitting set;
Storage unit, being configured to store will be by the program of this analyzer operation, and temporary transient storage is from the analysis result of this analyzer output;
Display unit is configured to show this analysis result;
Communication module is configured to transmit this analysis result to remote terminal; With
Side wall is installed between this optical transmitting set and this optical receiver, with the interference that prevents to be caused by the light that generates from this optical transmitting set.
9. reader according to Claim 8, wherein this optical transmitting set comprises the combination of red diode, green diode and blue diode, and this analyzer comes the described red diode of intermittent controlled, green diode and blue diode according to switching mode.
10. according to the reader of claim 9, wherein this communication module comprises radio-frequency (RF) identification (RFID) chip that links to each other with this analyzer.
11. according to the reader of claim 10, wherein this analyzer writes down this analysis result in this RFID chip.
12. according to the reader of claim 9, wherein this communication module comprises the mobile communication modulator-demodular unit, is configured to communicate by letter with this analyzer, and transmits this analysis result by mobile communications network to this remote terminal.
13. reader according to Claim 8 also comprises:
Fluid control module is configured to move, stop in this objective chip and mix microfluid, is used for effective analysis.
14. according to the reader of claim 13, wherein this fluid control module comprises:
Storage tank is configured to storing fluid;
Pump is configured to transmit fluid;
Valve is configured to control the transmission of fluid; With
Fluid control mixer.
CN2007800449409A 2006-12-05 2007-12-04 Biochip reader Active CN101548184B (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
KR1020060122488 2006-12-05
KR20060122488 2006-12-05
KR10-2006-0122488 2006-12-05
KR1020070101594A KR100875996B1 (en) 2006-12-05 2007-10-09 Biochip Reader
KR10-2007-0101594 2007-10-09
KR1020070101594 2007-10-09
PCT/KR2007/006257 WO2008069554A1 (en) 2006-12-05 2007-12-04 Biochip reader

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CN101548184B CN101548184B (en) 2013-07-31

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Publication number Publication date
DE112007002956T5 (en) 2009-09-24
KR100875996B1 (en) 2008-12-26
JP2010511890A (en) 2010-04-15
CN101548184B (en) 2013-07-31
KR20080052349A (en) 2008-06-11

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