CN101653384B - Dental implant of surface nano-structure and manufacturing method thereof - Google Patents
Dental implant of surface nano-structure and manufacturing method thereof Download PDFInfo
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- CN101653384B CN101653384B CN200910055612XA CN200910055612A CN101653384B CN 101653384 B CN101653384 B CN 101653384B CN 200910055612X A CN200910055612X A CN 200910055612XA CN 200910055612 A CN200910055612 A CN 200910055612A CN 101653384 B CN101653384 B CN 101653384B
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Abstract
The present invention provides a dental implant of a surface nano-structure and a manufacturing method thereof. The dental implant has a cylindrical structure with 1nm-500nm of the surface grain size and has a uniformly distributed micron-sized pore structure. The dental implant manufactured according to the invention has excellent osseous tissue compatibility, which can induct the bone deposition faster, increases the binding rate between the implant and the osseous tissue and furthermore increases the binding strength between the dental implant and the osseous tissue thereby increasing long-term clinical stability and success rate of dental implant.
Description
Technical field
What the present invention relates to is product of a kind of dental care technical field and preparation method thereof, specifically is tooth implant of a kind of surface nano-structure and preparation method thereof.
Background technology
Dental Implant can reduce base or exempt base, brings comfortablely and attractive in appearance to the patient, and can farthest recover masticatory function, and the promotion metabolism of bone tissue delays the absorption of alveolar bone, improves patient's quality of life, thereby is used widely clinical.Implantation body mainly is divided into metal and alloy thereof, pottery, macromolecular material and carbon-based material etc. clinically.Wherein, pure titanium, titanium alloy and stainless steel and other metal materials have excellent biological compatibility, and suitable mechanical mechanics property and advantage such as corrosion-resistant are the tooth implants of using always.But the interface binding power of implantation body and osseous tissue is lower and long-time stability relatively poor be the major defect of this type material implantation body.
For shortening metal implantation body-osseous tissue healing time, improve the bone integration rate, to obtain permanent more, reliable clinical curative effect, it is one of effective way that tooth implant is carried out surface treatment.Research in recent years shows that dental implant surface roughened and bioactivity coatings help implantation body's synosteosis.Find through searching document; Vanzillotta etc. are at " Dental Materials " (dental material; 2006 22 phase 275-282 pages or leaves) " the Improvement of in vitro titanium bioactivity by three different surfacetreatment " that delivers on (three kinds of different surface treatment method methods have improved the external biological activity of titanium); Adopt mixed acid to handle pure titanium surface; The result shows treated pure titanium rough surface property raising, the phosphatic deposition of type of helping bone more, and roughening is combined with important function in early days to implant and osseous tissue.Barrere etc. are at " Journal ofbiomedical material research " (bio-medical material research periodical; 2003 37 phase 655-665 pages or leaves) " the Osteointegration of biomimetic apatite coating applied onto dense andporous metal implants in femurs of goats " that delivers on (fine and close and porous metal implants surface biomimetic apatite coating is implanted the bone of goat femur and integrated research) shows; Compare with coating material not; The HA coated implants has bone fixation quickly, and has long-time stability.But still there are problems in the tooth implant of above-mentioned material, improves bone and implant bond strength effect and not obvious like rough surface, and coating combines problem with the interface that exists of matrix, and coating is prone to dissolving, peels off.
Recently there are some researches show; Osteoblast is suitable to interact with nanostructured or Nanosurface; Inorganic constituents in the body bone tissue is nanostructured, is 10～50nm like knitmesh bone inorganic constituents crystal grain, and tabular bone crystallite dimension diametric(al) is 2～5nm; Be about 20～50nm, nanostructured helps bone and grows into and improve combining of implant and host bone.The nano structural material surface energy increases, and helps adsorbed proteins (like Fibronectin, osteopontin etc.), and osteoblast sticking with function such as metabolism above that significantly improved.
Summary of the invention
The present invention is directed to the above-mentioned deficiency that existing tooth implant exists, tooth implant of a kind of surface nano-structure and preparation method thereof is provided, its surface microstructure is a nanoscale, can adsorbed proteins, induce bone apposition; The surface has loose structure simultaneously, effectively improves bone and grows into, and further enhance bone combines; Nanosurface and matrix are an integral body, have gradient-structure, have overcome the interface problem of coating structure.
The present invention realizes through following technical scheme:
The tooth implant that the present invention relates to surface nano-structure is a cylindrical structural; The surface microstructure yardstick of this tooth implant is 1nm～500nm; And have equally distributed micron order hole structure, aperture 0.1～10 μ m, described tooth implant are that pure titanium or titanium alloy material are processed.
The present invention relates to the method for preparing of the tooth implant of above-mentioned surface nano-structure, may further comprise the steps:
The first step, cylindrical tooth implant precast body is handled on the nano surface datatron, obtained the surface nano-structure of different scale.
The crystal particle scale of described surface nano-structure is 1～500nm.
Described cylindrical tooth implant is that pure titanium or titanium alloy material are processed.
Second the step, the tooth implant that has surface nano-structure is carried out acid treatment, make the micron order hole that formation is evenly distributed on the surface nano-structure.
Described acid treatment is meant: tooth implant was soaked under room temperature environment in the hydrochloric acid solution of 0.5-1.5mol/L 30-120 minute;
The diameter of described submicron order hole is 0.1～10 μ m.
The tooth implant that the present invention prepares gained has good bone biocompatibility; Can induce bone apposition and bone to grow into sooner; Improved the combination rate of implantation body and osseous tissue; And strengthened the bond strength of tooth implant and osseous tissue, thereby improved long-term clinical stability of tooth implant and success rate.
Description of drawings
Fig. 1 is the structural representation of nano surface tooth implant of the present invention.
Fig. 2 is the surface nano-structure sem photograph of embodiment 1 nano surface tooth implant.
Fig. 3 is the surperficial submicron order hole sketch map of embodiment 1 nano surface tooth implant;
Wherein: a is for amplifying 500 times, and b is for amplifying 2000 times.
Fig. 3 for embodiment 1～4 nano surface tooth implant and the common tooth implant plantation different time that is untreated after with osseous tissue adhesion sketch map.
The specific embodiment
Elaborate in the face of embodiments of the invention down, present embodiment provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment being to implement under the prerequisite with technical scheme of the present invention.
Embodiment 1:
As shown in Figure 1, the tooth implant 3 of present embodiment preparation specifically is arranged at the lower end of base station 2, and corona 1 is fixedly set in the upper end of base station 2.The preparation of described tooth implant 3 specifically may further comprise the steps:
Adopt the cylindrical tooth implant of nano surface processor pair to handle, make implantation body form surface nano-structure, as shown in Figure 2, the surface microstructure size reaches about 10～50nm.
Adopt 0.5mol/L hydrochloric acid that Nanosurface is handled then, make surface nano-structure form the micron order hole, shown in Fig. 3 a and 3b, the diameter of described micron order hole is 100nm～10 μ m, and this micron order hole is at the dental implant surface uniform distribution.
Embodiment 2:
Adopt the cylindrical tooth implant of nano surface processor pair to handle, make implantation body form surface nano-structure, the surface microstructure size reaches about 50～100nm.
Adopt 1mol/L hydrochloric acid that Nanosurface is handled then, make to form the micron order hole on the surface nano-structure, the diameter of described micron order hole is 100nm～10 μ m, and this micron order hole is at the dental implant surface uniform distribution.
Embodiment 3:
Adopt the cylindrical tooth implant of nano surface processor pair to handle, make implantation body form surface nano-structure, the surface microstructure size reaches about 100～500nm.
Adopt 1mol/L hydrochloric acid that Nanosurface is handled then, make to form the micron order hole on the surface nano-structure, the diameter of described micron order hole is 100nm～10 μ m, and this micron order hole is at the dental implant surface uniform distribution.
Embodiment 4:
Adopt the cylindrical tooth implant of nano surface processor pair to handle, make implantation body form surface nano-structure, the surface microstructure size reaches about 1～10nm.
Adopt 1.5mol/L hydrochloric acid that Nanosurface is handled then, make to form the micron order hole on the surface nano-structure, the diameter of described micron order hole is 100nm～10 μ m, and this submicron order hole is at the dental implant surface uniform distribution.
The nano surface tooth implant of embodiment 1～4 is implanted animal mandibular premolar district alveolus respectively, and the common implantation body of planting simultaneously without above-mentioned processing is contrast, respectively 1,2, passes through to release experiment test implantation body-synosteosis power after 3 months.Fig. 4 has shown the time changing curve of implantation body and synosteosis power.Implantation body implants behind the jawbone with on every side osseous tissue and forms an overall structure, and it can bearing load under functional status, and load is distributed and transmission.The people is 40-1200N in the scope of normally chewing physiologic occlusion power under the situation, and this requires implantation body and osseous tissue need keep high adhesion and stability.Visible from Fig. 4, the adhesion of nano surface tooth implant and bone is far above matched group implantation body, especially being up to more than the 2000N with the adhesion of bone after 3 months, can bear normal interlock behavior fully.
Claims (1)
1. the method for preparing of the tooth implant of a surface nano-structure; Described tooth implant is a cylindrical structural, and its surface microstructure yardstick is 1nm～500nm, and has equally distributed micron order hole structure; It is characterized in that said method for preparing may further comprise the steps:
The first step, cylindrical tooth implant precast body is handled on the nano surface datatron, obtained the surface nano-structure of different scale;
Second the step, the tooth implant that has surface nano-structure is carried out acid treatment, make the micron order hole that formation is evenly distributed on the surface nano-structure.
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| CN200910055612XA CN101653384B (en) | 2009-07-30 | 2009-07-30 | Dental implant of surface nano-structure and manufacturing method thereof |
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| CN200910055612XA CN101653384B (en) | 2009-07-30 | 2009-07-30 | Dental implant of surface nano-structure and manufacturing method thereof |
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| CN101653384A CN101653384A (en) | 2010-02-24 |
| CN101653384B true CN101653384B (en) | 2012-02-15 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919741B (en) * | 2010-09-28 | 2012-09-05 | 吉林大学 | Dental implant with micron-nanometer multi-grade micro-surface structure and preparation method |
| CN102670316A (en) * | 2011-03-17 | 2012-09-19 | 财团法人交大思源基金会 | Artificial tooth root with nanostructure |
| CN105911076B (en) * | 2016-03-17 | 2018-07-24 | 杭州越波生物科技有限公司 | A method of measuring bone-planting body Percentage bound using Microct |
| CN107252358A (en) * | 2017-01-17 | 2017-10-17 | 吴栋 | A kind of tooth implant and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5876453A (en) * | 1994-11-30 | 1999-03-02 | Implant Innovations, Inc. | Implant surface preparation |
| CN1381615A (en) * | 2002-03-01 | 2002-11-27 | 西安交通大学 | Porous nano titanium oxide base heterogeneous bioactive surface and its preparing process |
| US6527938B2 (en) * | 2001-06-21 | 2003-03-04 | Syntheon, Llc | Method for microporous surface modification of implantable metallic medical articles |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5876453A (en) * | 1994-11-30 | 1999-03-02 | Implant Innovations, Inc. | Implant surface preparation |
| US6527938B2 (en) * | 2001-06-21 | 2003-03-04 | Syntheon, Llc | Method for microporous surface modification of implantable metallic medical articles |
| CN1381615A (en) * | 2002-03-01 | 2002-11-27 | 西安交通大学 | Porous nano titanium oxide base heterogeneous bioactive surface and its preparing process |
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