CN101933803A - Cardiac mapping signal analyzing and processing device and method - Google Patents
Cardiac mapping signal analyzing and processing device and method Download PDFInfo
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Abstract
The invention provides a cardiac mapping signal analyzing and processing device and method, in particular to a device and method for analyzing the rhythm state of cardiac mapping signals. The device of the invention comprises a mapping electrode, a multistage amplifier, a data acquisition card, an acquisition module, a signal analyzing and processing unit and an output device. The method of the invention is based on the autocorrelation function and is characterized in that the time interval between the maximum peak and the second submaximum peak in the autocorrelation function sequence is used to estimate the main rhythm activation time interval of the signal, and the amplitude value of the submaximum peak is used as an index for measuring the regularity of the signal. The method of the invention can be used for the site analysis of the electrical activity of the heart in animal experiments and can also be used to assist the clinical diagnosis. As the system adopts the integrated acquisition and analysis structure and the method of the device is simple and effective, the device is characterized by wide application range and high real-time.
Description
Technical field
The present invention relates to biomedicine signals APU and method, relate in particular to a kind of analysis of cardiac mapping signal analysis and processing devices and methods therefor that is used for.
Background technology
Cardiac mapping is meant from cardiac electrical activity and sets about, to arrhythmia discern, judgement and location process.The common way of cardiac mapping is: at first, the area-of-interest on the heart is divided into tiny site, lays mapping electrode or injecting voltage fluorescent dye sensitive in each site, and confirm the physical location in each site; Secondly, write down the potential change that myocardial cell group excitement causes under each site; At last, by observing in the contrast area-of-interest each site mapping signal in the variation during the arrhythmia and association between them and difference, researcher can carefully in depth be understood ARR electrophysiological mechanism, therefrom seek with ARR triggering with keep the key factor that closely links to each other.And then the doctor can select suitable treatment means and strategy at these key factors.On the other hand, for cardiac electrical activity is carried out more comprehensively, finer observation, the development of cardiac mapping technology at present presents the trend of mapping site " big quantity, high accuracy ".In nearest research, the order of magnitude in mapping site is generally more than 100.This certainly will bring the cardiac mapping data of magnanimity.Therefore, the data analysis blood processor that design is relevant, research valid data analytical method in the hope of extract key message from mass data, just become an important topic of cardiac mapping technology.
In addition, rhythm analysis is present emerging a kind of cardiac mapping signal analysis direction, is intended to study the state of the rhythmicity that the corresponding myocardial cell group of mapping signal institute participates in cardiac electrical activity (also i.e. periodicity).Among the result of rhythm analysis, most critical be excited interval (or frequency) and two attributes of signal alignment degree of predominant rhythm.What the former reflected is that myocardial cell group maximum of probability ground participates in cardiac electrical activity with which rhythm and pace of moving things; What the latter was reflected is the influence whether the myocardial cell group is subjected to the excited granting of a plurality of cardiac muscles source.Under normal circumstances, sinuatrial node is the position of unique granting electrostimulation in the heart, and the process of all myocardial cell participation electrical activities all is subjected to its domination in the heart.At this moment, the cardiac mapping signal only reflects single sinus rhythm.But when some arrhythmia takes place, the excited source of one or more dystopys may appear in the heart.Electrostimulation also can be provided in the excited source of dystopy, and its excited frequency ratio hole sexual excitation is high significantly.At this moment, sinus rhythm and ectopic rhythm combined effect cause the myocardial cell excitement to present disturbance state on heart.This state can be embodied in the cardiac mapping signal equally.Therefore, doctor or researcher can be started with from the mapping signal, by the method for rhythm analysis, find out and locate the dystopy that exists in the heart during the arrhythmia and drive, thereby provide target for further treatment.
Existing rhythm analysis method is many based on Fourier transformation, the power spectrum of calculating mapping signal, and with the peak-peak in the power spectrum as result of calculation.But because Fourier transformation can produce a large amount of harmonic components, these harmonic waves might cause the erroneous judgement of analysis result; On the other hand, the cardiac mapping signal itself is comprising the frequency content of various complexity, and these compositions also can cause the skew of power spectrum maximum peak, thus the impact analysis effect.Practical application also shows, based on the rhythm analysis method of Fourier transformation only at a little less than the rhythmicity, the cardiac mapping signal of complicated irregularity has good effect; But the cardiac mapping signal strong to rhythmicity, result of calculation and truth often have a tremendous difference.
Summary of the invention
In order to solve above-mentioned problems of the prior art, the object of the invention is to provide a kind of cardiac mapping signal analysis and processing apparatus and method, particularly a kind of devices and methods therefor of analysis of cardiac mapping signal rhythm and pace of moving things state.
Characteristics of the present invention are: data collection and analysis is integrated, and is widely applicable, real-time.The present invention can be used for the field assay of zoopery to the mapping cardiac electrical activity; Also can be used to assist clinical diagnosis.
The cardiac mapping signal analysis and processing device that the present invention proposes, form by mapping electrode 1, multistage amplifier 2, data collecting card 3, acquisition module 4, signal analysis and processing unit 5 and output display device 11, mapping electrode 1, multistage amplifier 2, data collecting card 3, acquisition module 4 and signal analysis and processing unit 5 connect successively, the outfan of acquisition module 4 and signal analysis and processing unit 5 is connected output display device 11 respectively, wherein:
Mapping electrode 1 is used to be placed in the area-of-interest on the heart;
Signal analysis and processing unit 5 carries out analyzing and processing to the electrocardiographicassignment assignment test data;
Among the present invention, described signal analysis and processing unit 5 is made up of pretreatment module 6, exciting extraction module 7, frequency-domain analysis module 8, time-domain analysis module 9 and nonlinear analysis module 10 constantly, pretreatment module 6, exciting extraction module 7, time-domain analysis module 9 constantly connect successively, the outfan of pretreatment module 6 connects frequency-domain analysis module 8 and nonlinear analysis module 10 respectively, and the outfan of frequency-domain analysis module 8, time-domain analysis module 9 and nonlinear analysis module 10 is connected output display device 11 respectively; Pretreatment module 6 is used for removing synergetic external noise of cardiac mapping signal and interference; Exciting extraction module 7 constantly is intended to extract the moment of its corresponding myocardial cell group excitement from the cardiac mapping signal; The time domain specification of time-domain analysis module 9 analytic signals; The frequency domain characteristic of frequency-domain analysis module 8 analytic signals; Nonlinear analysis module 10 is extracted more complicated nonlinear transformations from signal.
Among the present invention, described mapping electrode can be a flexible electrode etc.
Among the present invention, comprise the rhythm analysis unit 12 that is used for analysis of cardiac mapping signal rhythm and pace of moving things state in the described nonlinear analysis module 10.
Among the present invention, what described rhythm analysis unit 12 adopted is auto-correlation function sequence Peak Intensity Method: as the estimation of exciting interval of the main rhythm and pace of moving things of this segment signal, the range value at inferior big peak is as the measurement index of this segment signal alignment degree with maximum peak in the signal auto-correlation function sequence and time big peak-to-peak interval.
Among the present invention, mapping electrode .1, multistage amplifier 2 and data collecting card 3 are realized by hardware circuit; Acquisition module 4 and signal analysis and processing unit 5 can be realized on computers or on the DSP; 11 of output display devices can be selected in liquid crystal display screen, computer display or the alarm etc. any for use.
A kind of cardiac mapping signal analysis treating method that the present invention proposes, particularly a kind of rhythm analysis method that is applicable to zoopery scene or clinical practice.This method is based on the auto-correlation function of cardiac mapping signal, and its principle is that the auto-correlation function of periodic signal also is a periodic signal, and the cycle of auto-correlation function is consistent with the signal period.As previously mentioned, during some arrhythmia, the excited source of dystopy except that sinuatrial node may appear in the heart.At this moment, the cardiac mapping signal can be considered as sinus rhythm signal and ectopic rhythm signal and forms by ad hoc rule stack, reconstruct.Therefore, the prosodic feature of the auto-correlation function of mapping signal and two species rhythm signals (cycle, signal amplitude) is closely related.So we can extrapolate the current rhythm and pace of moving things state of mapping signal from the auto-correlation function of signal.
The cardiac mapping signal analysis treating method that the present invention proposes, concrete steps are as follows:
A. from animal or human heart, gather the cardiac mapping data;
B. select interested mapping site and time section, data are sent into the signal analysis and processing unit;
C. the cardiac mapping data are carried out pretreatment, eliminate various interference and noise;
D. the signal to each mapping site carries out rhythm analysis, its auto-correlation function sequence of calculating one by one, and computing formula is as follows:
Wherein x is the mapping signal, and τ is the relative time displacement, and n is the signal sequence number;
E. the auto-correlation function sequence is carried out normalization;
F. search its maximum peak and time big peak in the auto-correlation function sequence after each normalization, with maximum peak and time big peak-to-peak interval as the estimation of excited interval of this segment signal predominant rhythm, the range value at inferior big peak is as the measurement parameter (amplitude is big more, and signal is regular more) of this segment signal alignment degree;
G. for single mapping site, observe the envelope of its signal auto-correlation function sequence, the myocardial cell electrical activity that can extrapolate under this site is influenced by several species rhythms, based on which kind of;
H. for mapping interested zone, can draw pseudocolour picture or stereogram according to each site predominant rhythm exciting interval, alignment degree in the zone, to embody during the arrhythmia distribution situation of the various excited rhythm and pace of moving things on the heart intuitively.
Among the present invention, when the myocardium electric excitation propagation direction of research, can call exciting extraction module constantly, promptly analyze the sequential of myocardial cell group excitement under each mapping site, its result of calculation can be used for the rhythm analysis result with reference to contrast.
Compared with prior art, the present invention has following beneficial effect:
1. harvester and analysis process system are blent into one, the analysis and processing method that is adopted is simply effective, therefore can realize the field assay in zoopery or the clinical treatment;
2. the rhythm analysis method based on auto-correlation function has stronger adaptability, under normal cardiac rhythm He during the arrhythmia good analysis result can both be arranged.Thereby the arrhythmogenic mechanism of the method detection that can be used for performing the operation and long-range research.
Description of drawings
Fig. 1 is the structural representation of apparatus of the present invention;
Fig. 2 is the structural representation that apparatus of the present invention are applied to epicardial mapping zoopery embodiment 1;
Fig. 3 is the workflow diagram that the inventive method is applied to epicardial mapping zoopery embodiment 1;
Fig. 4 is the operation result sketch map of the inventive method.
Number in the figure: the 1st, the mapping electrode, the 2nd, multistage amplifier, the 3rd, data collecting card, the 4th, acquisition module, the 5th, the signal analysis and processing unit, the 6th, pretreatment module, the 7th, exciting extraction module constantly, the 8th, frequency-domain analysis module, the 9th, the time-domain analysis module, the 10th, nonlinear analysis module, the 11st, output display device, the 12nd, rhythm analysis unit.
The specific embodiment
The present invention is further described below in conjunction with drawings and Examples.
Embodiment 1: as shown in Figure 1, the cardiac mapping signal analysis and processing device that the present invention proposes comprises: a cover mapping electrode 1 is used for gathering the cardiac mapping signal from the heart region of interest; One cover multistage amplifier 2, its input were intended to the cardiac mapping signal of millivolt level is amplified to the volt level, simultaneously unwanted frequency composition in the filtered signal through cable and 1 terminal linking to each other of mapping electrode; One blocks of data capture card 3, input insert the output of amplifier 2, be used for analog electrocardiogram mapping signal is sampled, and analog digital conversion, and deposit the data buffer memory of capture card 3 in; One cover acquisition module 4 periodically reads the cardiac mapping data, and saves as data file from the data buffer memory of capture card 3; A signal analysis and processing unit 5 comprises pretreatment 6, exciting extracts 7 constantly, modules 10 such as frequency-domain analysis 8, time-domain analysis 9 and nonlinear analysis, is used for the electrocardiographicassignment assignment test signal that has collected is carried out the analyzing and processing of online or off-line; An output display device 11 is used for the display analysis result.Mapping electrode 1, multistage amplifier 2, data collecting card 3 are realized by hardware in the device; Acquisition module 4 and signal analysis and processing unit 5 can be realized on computer or DSP; Two parts link to each other by the usb data line; Output display device 11 can be selected in liquid crystal display screen, computer display or the alarm etc. any for use.During work, the signal analysis and processing unit reads one section cardiac mapping data according to preestablishing of operator from internal memory or data file; At first, carry out noise jamming in the pretreatment erasure signal; Secondly, the excited time information of myocardial cell in the extraction signal; Once more, call analysis and processing unit in one or more analysis module according to setting; At last analysis result is transferred to output display device, presents in modes such as pseudocolour picture or stereograms.
Fig. 2 is that the present invention is used for the zooperal embodiment of epicardial mapping.In this example, the mapping zone on the heart is visceral pericardium (being exterior heart surface).Mapping electrode 1 is opened at surgical operation under the prerequisite of breast and is sewn onto on the visceral pericardium; The amplification of multistage amplifier 2 is chosen 500-2000 doubly usually, and effective frequency range is the 3-600 hertz; The sample frequency of data collecting card 3 is 2000 hertz.Be the real-time that guarantees to handle, signal analysis and processing unit 5 only carries out rhythm analysis 12 usually at the zoopery scene.Its workflow is: at first, the cardiac mapping data in the internal memory are carried out pretreatment 6; Secondly, pretreated data are sent into rhythm analysis unit 12 carry out computings such as auto-correlation function; Result with rhythm analysis outputs to display device 11 with predominant rhythm scattergram and the distribution of signal alignment degree scattergram respectively at last; The wherein exciting moment extracts 7 and is optional module, and its operation result can be used for comparing with the result of rhythm analysis 12.
As shown in Figure 3, when the inventive method was carried out rhythm analysis to experimental data in the epicardial mapping zoopery, its workflow was:
1. gather the cardiac mapping signal by apparatus of the present invention from the animal exterior heart surface, and be converted into digital form;
From choose data matrix to be analyzed (data in a mapping site are delegation) according to the mapping interested site of setting in the parameter preset and mapping period (length be generally 5-20 second) the data;
3. treat analytical data and carry out pretreatment;
4. pretreated data matrix is carried out auto-correlation function line by line and calculate (scope of relative displacement be generally 0-2 second), after the normalization, obtain autocorrelation sequence;
(if necessary, the autocorrelation sequence scattergram is drawn on ground, site one by one, to analyze the rhythm and pace of moving things state of corresponding myocardial cell group excitement)
5. search the position at maximum peak and time big peak in the auto-correlation function sequence, as the estimation of excited interval of signal predominant rhythm, the range value in proper order big peak is as the index of gauge signal alignment degree with the interval at two peaks;
6. behind the rhythm and pace of moving things state that has write down all mapping site signals, draw predominant rhythm scattergram and alignment degree scattergram in the area-of-interest in the mode of pseudocolour picture.
Fig. 4 is that an anticipatory remark inventive method is applied to visceral pericardium zoopery analysis result sketch map.Experimental data is taken from the position, right auricle in the animal hearts, and the data time section is that afterwards 20 seconds of atrial fibrillation (a kind of complicated arrhythmia) take place animal.The analysis result sketch map is drawn with the form of pseudocolour picture, and the numerical range of various color representatives is labeled in the right side of figure.As previously mentioned, self correlation primary and secondary peak is the estimation of the excited interval of signal predominant rhythm part at interval.Fig. 4 a shows that two region memories of AB are in altofrequency excitement (excited interval＜100ms); And the excited interval in C zone, obviously will be grown than the AB zone.This phenomenon is to meet physical location relation between right auricle electrode (B sheet) and sinuatrial node (the excited interval of sinus rhythm is usually than the significant length in dystopy source), the stimulating electrode: the upper left quarter of B sheet is nearest from superior vena cava in the zoopery, and sinuatrial node is just near the sulcus terminalis of superior vena cava and right atrium intersection; And the stimulating electrode approximate location is as among the figure shown in ' 0 '.Fig. 4 b has further embodied the trizonal difference of ABC.The amplitude at self correlation time big peak is the index of gauge signal alignment degree.The signal alignment degree in C zone is minimum, and A is the highest, and B is low relatively.Fig. 4 c is the isochronograph analysis result of extraction module 7 (constantly exciting) of a-quadrant, can find that signal is propagated to left down in the a-quadrant.Three figure of comparison are confirmable to be, may there be the excited source of a dystopy near the stimulating electrode, the a-quadrant is the dominant paths that the atrial fibrillation excitement that provide in the dystopy source on the animal hearts when taking place is propagated, and the C zone is subjected to passing sinuatrial node under the influence that excitement is uploaded in excited and dystopy source simultaneously.
Claims (6)
1. cardiac mapping signal analysis and processing device, form by mapping electrode (1), multistage amplifier (2), data collecting card (3), acquisition module (4), signal analysis and processing unit (5) and output display device (11), it is characterized in that mapping electrode (1), multistage amplifier (2), data collecting card (3), acquisition module (4) and signal analysis and processing unit (5) connect successively, the outfan of acquisition module (4) and signal analysis and processing unit (5) is connected output display device (11) respectively, wherein:
Mapping electrode (1) is used to be placed in the area-of-interest on the heart;
Multistage amplifier (2) will be amplified to the amplitude that is fit to follow-up data capture card (3) collection from the faint electrocardiographicassignment assignment test signal of mapping electrode (1), and unwanted frequency composition in the filtered signal;
Data collecting card (3) is sampled to the electrocardiographicassignment assignment test signal after amplifying, and is converted into digital signal, and deposits in the capture card data buffer memory;
Acquisition module (4) reads in internal memory with the cardiac mapping data in the capture card data buffer memory, and periodically saves as data file;
Signal analysis and processing unit (5) carries out analyzing and processing to the electrocardiographicassignment assignment test data;
Output display device (11) is used to show the waveform and the analysis processing result of cardiac mapping data.
2. cardiac mapping signal analysis and processing device according to claim 1, it is characterized in that described signal analysis and processing unit (5) is by pretreatment module (6), exciting extraction module (7) constantly, frequency-domain analysis module (8), time-domain analysis module (9) and nonlinear analysis module (10) are formed, pretreatment module (6), exciting extraction module (7) constantly, time-domain analysis module (9) connects successively, the outfan of pretreatment module (6) connects frequency-domain analysis module (8) and nonlinear analysis module (10), frequency-domain analysis module (8) respectively, the outfan of time-domain analysis module (9) and nonlinear analysis module (10) is connected output display device (10) respectively; Pretreatment module (6) is used for removing synergetic external noise of cardiac mapping signal and interference; Exciting extraction module (7) constantly is intended to extract the moment of its corresponding myocardial cell group excitement from the cardiac mapping signal; The time domain specification of time-domain analysis module (9) analytic signal; The frequency domain characteristic of frequency-domain analysis module (8) analytic signal; Nonlinear analysis module (10) is extracted more complicated nonlinear transformations from signal.
3. cardiac mapping signal analysis and processing device according to claim 1 is characterized in that comprising in the described nonlinear analysis module (10) the rhythm analysis unit (12) that is used for analysis of cardiac mapping signal rhythm and pace of moving things state.
4. cardiac mapping signal analysis and processing device according to claim 1, what it is characterized in that described rhythm analysis unit (12) adopts is auto-correlation function sequence Peak Intensity Method: as the estimation of exciting interval of the main rhythm and pace of moving things of this segment signal, the range value at inferior big peak is as the measurement index of this segment signal alignment degree with maximum peak in the signal auto-correlation function sequence and time big peak-to-peak interval.
5. cardiac mapping signal analysis and processing device according to claim 1, it is characterized in that described output display device (11) be in liquid crystal display screen, computer display or the alarm any.
6. cardiac mapping signal analysis treating method is characterized in that concrete steps are as follows:
A. from animal or human heart, gather the cardiac mapping data;
B. select interested mapping site and time section, data are sent into the signal analysis and processing unit;
C. the cardiac mapping data are carried out pretreatment, eliminate various interference and noise;
D. the signal to each mapping site carries out rhythm analysis, its auto-correlation function sequence of calculating one by one, and computing formula is as follows:
Wherein x is the mapping signal, and τ is the relative time displacement, and n is the signal sequence number;
E. the auto-correlation function sequence is carried out normalization;
F. search its maximum peak and time big peak in the auto-correlation function sequence after each normalization, with maximum peak and time big peak-to-peak interval as the estimation of excited interval of this segment signal predominant rhythm, the range value at inferior big peak is as the measurement parameter of this segment signal alignment degree, be that amplitude is big more, signal is regular more;
G. for single mapping site, observe the envelope of its signal auto-correlation function sequence, the myocardial cell electrical activity that can extrapolate under this site is influenced by several species rhythms, based on which kind of;
H. for mapping interested zone, can draw pseudocolour picture or stereogram according to each site predominant rhythm exciting interval, alignment degree in the zone, to embody during the arrhythmia distribution situation of the various excited rhythm and pace of moving things on the heart intuitively.
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| CN111772621B (en) * | 2020-07-02 | 2023-06-02 | 复旦大学 | Multi-lead heart mapping signal analysis processing device and method thereof |
| CN112535483A (en) * | 2020-11-17 | 2021-03-23 | 东南大学 | Heart sympathetic activity detection device based on high-frequency electrocardio |
| CN112535483B (en) * | 2020-11-17 | 2021-09-03 | 东南大学 | Heart sympathetic activity detection device based on high-frequency electrocardio |
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