CN101943796A - Multi-spectrum endoscopic optics switching system - Google Patents
Multi-spectrum endoscopic optics switching system Download PDFInfo
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- CN101943796A CN101943796A CN201010262593.0A CN201010262593A CN101943796A CN 101943796 A CN101943796 A CN 101943796A CN 201010262593 A CN201010262593 A CN 201010262593A CN 101943796 A CN101943796 A CN 101943796A
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Abstract
The invention belongs to the technical field of endoscopic optics switching systems, in particular to a multi-spectrum endoscopic optics switching system, which solves the problem that the burden of hospitals and patients is increased, as the detection on one part needs multiple endoscopes and multiple sets of equipment although the existing endoscope category is various. The system comprises an excitation light filtering wheel arranged at the front part of a cold light source, and an emitting light filtering wheel which can be synchronously switched with the excitation light filtering wheel and is arranged between a CCD and light emitted by the endoscope; the excitation light filtering wheel and the emitting light filtering wheel are respectively provided with light filtering sheets N0. 2 to N0. 7. Compared with the prior art, the system of the invention has the following beneficial effects of greatly saving equipment expenses of medical institutions, mainly lightening the examination pain of the patients, and improving the diagnosing and treating effects.
Description
Technical field
The invention belongs to the technical field of endoscope optical system, be specifically related to a kind of multispectral endoscope optics switched system.
Background technology
The medical science endoscope is the visual plant of medical diagnosis and treatment, makes a general survey of the history of endoscope development, Wei Da progress each time, and all the scientific progress with epoch has close getting in touch,
First kind endoscope: visible light endoscope.
1, the available light epoch
The well-known doctor of ancient Greek, father's the uncommon ripple carat of title of medicine is arranged at the bottom of (Hippocrates, B.C. approximately 460-preceding 370) a kind of rectum speculum was once described, this speculum and our today, used apparatus was quite similar.These speculums once were used to spy on vagina and cervix, checked rectum, and were used to inspect in ear, the nose.What carried out at that time utilizing when these are checked is available light.
2, the external light source epoch
It is the apparatus that is used to observe bladder and rectum inside of light source with the candle that the Bozzini of Frankfurt, Germany in 1806 has made a kind of, form by a vase-like light source, candle and a series of eyeglass, be to be light source to burn kerosene and terebinthine lamp, 1867, from the dentist Bruck of Breslau with electric current make platinum filament ring hot luminescence and with observe patient's oral cavity as light source.
3, the built-in light source epoch
879 years Berlin Urology Surgery doctor Nitze have made first and have contained the endoscope (being cystoscope) of optical system, and its front end contains a prism, and this endoscope only is used to urinary system.The circulation frozen water is to avoid thermal burn in bladder for Nitze, because this endoscope can obtain than distinct image, Nitze also utilizes it to take pictures.Nitze had introduced the operation pipeline in his cystoscope afterwards.Famous scientist Edison had invented incandescent lamp in 1880, the Newman of Glasgow has replaced the used heating wire of illumination in the former cystoscope with miniature incandescent lamps after 3 years, it is foremost cystoscopic that Dittell in 1887 places bulb, and this illuminator becomes endoscope institute accepted standard mode in that in period.Boisseau du Rocher has introduced the endoscope that a kind of eyepiece can separate with shell in 1889, also can use different lens combinations by shell.
4, half of the built-in light source epoch can bend of the introducing of formula endoscope along with optical system, though hard tube formula endoscope is able to constantly improve and development, but because there is the physiological bending in the dissection in internal organs more, be difficult to abundant inspection with hard tube formula endoscope, half can bend the formula endoscope arises at the historic moment.Just once developed as far back as Mikulicz in 1881 and the endoscopes that front end 1/3rd places can become 30 degree angles, it is hard part and far-end is the zooperal OGD that is used for of soft section that Kelling had also once designed a kind of near-end.And truly first half can to bend the formula OGD be to be developed since 1928 with outstanding apparatus fabricate teacher Wolf cooperation by Schindler, and finally succeedd in 1932, name and be Wolf-Schindler formula gastroscope, this gastroscope diameter is 12mm, long is 77cm, optical system is made up of 48 lens, but be characterized in the front end tropism, the bending of certain limit is promptly arranged in stomach, make the patient can clearly observe the gastric mucosa image, this gastroscope front end has a smooth metal ball, insert more conveniently, bulb light brightness is stronger, air duct is arranged in order to gas injection, near-end is a hard pipe section, and the eye lens focusing is arranged.The initiative of Wolf-Schindler formula gastroscope, the new era of having opened up gastroscopy.After this, Wu Jingsheng, Benedict and Schindler etc. transform this formula gastroscope, and it is more complete to make it function, more practical.5, before new external the 50's of 20th century of light source epoch, what endoscope illumination adopted is inner light source, and illuminating effect is relatively poor, the image color distortion, and have and cause the danger that tissue is burnt.Just once described the application glass bar as far back as Smith in 1899 outer light source is imported observation chamber, Thompson also has similar description, and what he adopted is quartz pushrod.German Lamm in 1930 proposes and can conduct light source with thin glass fiber bundle together, and imagines and make soft gastroscope with glass fiber bundle, once with Schindler cooperation trial-production, does not succeed because of light insulation between fiber not solve.Holland Heel and U.S. Brien add a coating on fiber, solved interfibrous smooth Insulation Problems.Britain Hopkings in 1954 and Kapany have studied the precision of fiber and have arranged, solved the image transfer of fibrous bundle effectively, for fiberoptic practicality is laid a good foundation, the appearance of cold light source simultaneously, have light source to be moved on to external, light is passed in the body through light transmitting fiber and optical system.
6, the fiberendoscope in new external light source epoch
Hirschowitz in 1957 and his seminar have made in the world, and first is used to check stomach, duodenal light transmitting fiber scope prototype and has showed the light transmitting fiber scope of development voluntarily in AGA.In October, 1960 U.S.'s cystoscope fabricator company (ACMI) provides first commercial fibres endoscope to Hirschowitz, and then Japanese Olympas factory is on light transmitting fiber gastroscope basis, install biopsy device and camera additional, shown the stomach photography effectively.Initiative front end bent angle mechanism of Olympas factory in 1966, Machida factory adopted outside cold light source in 1967, and luminance brightness is heightened, and can find small lesion, and the visual field further enlarges, and can observe duodenum.Along with updating of auxiliary equipment,, make fiberendoscope not only can be used for diagnosis, and can be used for operative treatment as the development of operating theater instruments, camera chain.Lyons, France doctor Mouret had finished the first routine video-laparoscope cholecystectomy in the world on one's body a women in 1987.
The second class endoscope: ultrasonic endoscopic
People such as Japanese scholar session forever of a specified duration had started the scope that ultrasonic probe is housed at front end in 1977, survey heart through oesophagus, the 4th the European stomach of holding in hamburger in 1980, in the conference of duodenum endoscope, West Germany St rohm etc. has reported using ultrasound endoscopy 18 routine patients and has obtained pancreas and the paper of little pancreas cancer ultrasonoscopy, they adopt is that the ultrasonic probe of Japanese Aloka factory is combined closely at the EUS that head end constituted of the GF-B3 of Olympus factory type side viewing endoscope, this is a kind of prototype of radial fan type EUS, and has introduced a kind of prototype of line style EUS from Dimago of the U.S. etc.Producer such as people such as J suyoshi and Olympus, Aloka, raised path between farm fields field, Toshiba has carried out a series of improvement again to EUS subsequently.
The 3rd class endoscope: fujinon electronic video endoscope
U.S. Welch Allyn company in 1983 development and using miniature imageing sensor have replaced the light transmitting fiber of scope to lead the picture art, have declared the historical breakthrough of another time on the birth-scope development history of video image dendoscope.Fujinon electronic video endoscope mainly is made up of scope, Digital Multimedia System center and three major parts of TV monitor, also be equipped with some servicing units in addition, as video recorder, camera, attractor and be used for importing used various treatment apparatus of the keyboard of various information and diagnoses and treatment etc.Its imaging mainly depends on the CCD of shank head end equipment, and CCD resembles a microcam handles image through image processor after, is presented on the screen of TV monitor.Than the clear picture of common photoconduction fiberendoscope, color and luster is true to nature, and resolution is higher, and can watch simultaneously for many people.Produce the more famous company of video image dendoscope in the world the refined human relations of the U.S. and the Olympus of Japan etc. are arranged.Because the appearance of video image dendoscope has started historical new page for the diagnosis and the treatment of scope for over 100 years more than a hundred years, in clinical, teaching and scientific research, given play to its huge advantage.
The 4th class endoscope: CT CTVE
CT CTVE (VE) is the inspection means of a kind of non-invasive virtual reality of combining with the modern medicine iconography of advanced computer science.CTVE utilizes special computer software that the view data that the spiral CT volume scan obtains is handled, and reconstructs the inside surface stereographic map of cavity organ, thereby reaches the effect of fiberendoscopy.Since this technology in 1994 is come out, existing both at home and abroad a few experiments and clinical practice report.
The 5th class endoscope: extraordinary light endoscope
1, amplifies the pigment scope
Amplification pigment scope can significantly improve the recall rate of flat type and umbilicate type pathology.Amplification electron intestines mirror is at intestines mirror front end a multiplying arrangement to be arranged, and by manual zoom, but the enlargement factor regulated at will is amplified 60～100 times usually.Whether behind 0.2%～0.4% indicarminum or 0.2%～0.5% the methylene blue staining, estimating glandular tube opening form with amplification electron intestines mirror can be to neoplastic lesion and be that cancer is made roughly judgement under mucous membrane cancer or the mucous membrane.
2, arrowband imaging technique (NBI)
This technology can effectively be observed alimentary canal mucous membrane capillary form and be changed.The NBI scope is filtered " white light " by light filter, only stays the indigo plant of 415 nm, 540 nm and 600 nm wavelength, green, red arrowband light wave.Blue wave band (415 nm) penetrates more shallow, reflected by the capillary of mucous membrane surface, red wave band (600 nm) can reach submucosa deeply, be used to show rete vasculosum under the mucous membrane, green wave band (540 nm) then can show the blood vessel in middle layer preferably, and its shortcoming is to judge that the specificity of tumor invasive depth is relatively poor.
3, autofluorescence (AF) technology
Under the situation of not using the extrinsic fluorescence material, use low power laser irradiation gastrointestinal tract mucosa, can excite tissue produce the fluorescence longer than excitation wavelength, i.e. AF, it derives from intrinsic fluorescence activity molecule in the body.Human tissue organ is after cancerating, the change of the biochemical component of local organization, physiological environment and morphosis makes the autofluorescence spectrum of tumor tissues and normal structure produce difference, therefore can distinguish tumor tissues and normal structure according to difference, show the autofluorescence image with pseudo-colours, normal mucous membrane is blue-green or cyan, and pernicious focus and dysplasia district are kermesinus or rufous.
4, intelligent pigment strengthens (FICE) system, is with video picture (MBI) more
FICE utilizes the light of different wave length can penetrate the principle of different depth mucous membrane, utilize special wavelength, the endoscopic image of combination different colours, different wavelength range, degree of reflection is organized in setting from shallow to dark, and carry out image reconstruction according to the wavelength of wanting, can more clearly observe vascular opening form and capillary network, provide strong weapon for finding mucous membrane trickle concavo-convex variation, particularly infantile tumour early.
5, near infrared endoscope
The near infrared ray video image dendoscope, near infrared ray is penetrate tissue dearly, and the light of conventional scope can not.In vivo spectrophotometry shows that infrared ray can penetrate belly and coat of the stomach when 620～820nm wavelength, after intravenous injection saline or indocyanine green, on monitor, can see the stomach blood vessel that is netted, and the blood vessel structure at gastroenteric tumor position also there is certain value to the judgement of tumor invasive depth.Use the near infrared ray electronic endoscopy and help correctly to estimate the EGC scope, and can understand invasive depth and have or not metastases in local lymph node.
In sum, the most basic endoscope is the incandescence endoscope at present, autofluorescence endoscope, narrow spectrum (blue and green) endoscope, infrared light endoscope and near infrared light endoscope have appearred again recently, these endoscopes all provide effective biological information for the diagnosis and the treatment of endoscope from different perspectives, medical diagnosis on disease under the endoscope all there is in various degree help, but all equipment can not be bought entirely in a hospital.Though above-mentioned endoscope all has in various degree help to medical diagnosis on disease, a patient can not extract insertion with different endoscopes and carry out repeatedly in same checking process.
Summary of the invention
Though the present invention is various in order to solve existing endoscope kind, check that same position just needs many endoscopes and many complete equipments, increased the problem of hospital and patient's burden, a kind of multispectral endoscope optics switched system is provided.
The present invention adopts following technical scheme to realize:
Multispectral endoscope optics switched system, it is characterized in that comprising be arranged at before the cold light source excite filter wheel and be arranged at CCD and endoscope emission light between can with the emission filter wheel that excites filter wheel to switch synchronously, excite and have 7 holes on the filter wheel, No. 1 hole is a through hole, 2 to No. 7 the hole is provided with exciter filter 2 to No. 7, also have 7 holes on the emission filter wheel, No. 1 hole is a through hole, 2 to No. 7 the hole is provided with the emission optical filter 2 to No. 7, the specification such as the following table of described exciter filter and emission optical filter:
| The exciter filter sequence number | Emission optical filter sequence number | The optical |
| 2 | 2 | Purple light |
| 3 | 3 | |
| 4 | 4 | Dark green |
| 5 | 5 | |
| 6 | 6 | Red light |
| 7 | 7 | Near infrared light |
The big 50nm of emission optical filter wavelength ratio exciter filter wavelength of corresponding sequence number;
Be arranged within the light source panel by cold light source and the Lights section that excites filter wheel to form, establish light source switch, luminance brightness knob, harmonic knob and light delivery outlet on the light source panel, excite filter wheel to be connected with rotating drive link, the drive link end is connected with the harmonic knob;
Comprise that the camera part of launching filter wheel is arranged between endoscope eyepiece end and the CCD camera, camera part also comprises the filter wheel fixed bin, the emission filter wheel is by the rotatable inside that is installed on the filter wheel fixed bin of rotating shaft, filter wheel fixed bin one end is connected with the connector of endoscope eyepiece end, and the other end is connected with the CCD camera.
The present invention excites the mode that filter wheel and emission filter wheel switch synchronously to have three kinds: hand, manual distance type and foot control distance type.
When hand switched, the filter wheel that excites of the Lights section passed through the switching that hand rotation harmonic knob is realized exciter filter; The filter wheel fixed bin upper shed of camera part, the neighboring part of emission filter wheel is stretched out opening, the outward flange of emission filter wheel is provided with 2 to No. 7 emission optical filters and switches the sign that puts in place, and the switching of emission filter wheel is realized to marker location in the neighboring that manually promotes the emission filter wheel.
Switching mode is a distance type, the motor that is connected and drives its rotation with drive link is set in the light source panel, also be provided with the motor that is connected and drives its rotation with rotating shaft in the filter wheel fixed bin, also be provided with telepilot in addition, the radiating circuit that transmits is set in the telepilot, and the Lights section and camera part are provided with the reception control circuit that received signal is set and controls motor.Telepilot can be manual telepilot, and the petcock of control radiating circuit is set on it.Described telepilot also can be foot-operated telepilot, and the foot-switch of control radiating circuit is set on it.
The present invention is configured in a kind of multispectral endoscope optics switched system on the modern various endoscope, makes an endoscope have multiple function and multiple use, with the fast development of guiding endoscopic technique of new generation.
The relative prior art of the present invention has following beneficial effect: be on the basis of existing incandescence endoscope, increased the function that multiple spectrum switches, change endoscope into multiple spectrum function by the incandescence endoscope, saved the cost of equipment of medical institutions greatly, main is the inspection misery that has alleviated patient, has improved diagnosis and result of treatment.The present invention gets involved diagnosis and the treatment that the endoscope field not only helps disease, will promote the research that bio-photon is learned under the endoscope in addition, study different fluorescent dyes, fluorescent marker effect in disease takes place and develops promotes the arrival in new epoch of endoscope subject.
Figure of description
Fig. 1 is a synoptic diagram of the present invention
Fig. 2 is a light source panel synoptic diagram
Fig. 3 is the Lights section inner structure synoptic diagram
Fig. 4 is the camera part schematic appearance
Fig. 5 is a camera part inner structure synoptic diagram
Fig. 6 is the Lights section filter wheel control system figure
Fig. 7 is the circuit diagram that transmits
Fig. 8 is camera part filter wheel control system figure
Fig. 9 is reception control circuit figure
Among the figure: the 1-cold light source, 2-excites filter wheel, the 3-light pipe, 4-launches filter wheel, 5-light source panel, 6-CCD, 7-image-signal processor, 8-digital collection card, the 9-display, 10-computing machine, 11-light source switch, 12-luminance brightness knob, 13-harmonic knob, 14-light delivery outlet, 15-drive link, 16-endoscope eyepiece end, 17-filter wheel fixed bin, 18-CCD camera, 19-video data line, the 20-rotating shaft, 21-motor, 22-reception control circuit.
Embodiment
In conjunction with the accompanying drawings the specific embodiment of the present invention is described further.
The medical science endoscope is generally by endoscope, light source, camera system, and display and image processing system are formed.Multispectral endoscope optics switched system of the present invention (as shown in Figure 1), in cold light source, the bulb front has increased and has excited filter wheel and 2-7 exciting light optical filter, the fluorescence of 6 kinds of different wave lengths of output.Between CCD and endoscope emission light, increase an emission filter wheel, settle emission light optical filter 2-7 number, cooperate other equipment to constitute multispectral fluorescence endoscopic mirror system, as following table.
| The exciter filter sequence number | Emission optical filter sequence number | The optical filter color | Excitation wavelength (nm) | Wavelength of transmitted light (nm) | |
|
| 1 | 1 | Incandescence | Free of light filter | Free of light | Routine operation | |
| 2 | 2 | Purple | 408 | 450 | Autofluorescence | |
| 3 | 3 | Blue | 415 | 465 | The shallow- |
|
| 4 | 4 | Bottle green | 375～440 | 430-500 | 5-aminolevulinic acid (ALA) |
|
| 5 | 5 | Green | 540 | 620 | The blood vessel in |
|
| 6 | 6 | Red | 600 | 680 | Mucous membrane deep layer trunk | |
| 7 | 7 | Near infrared light | 710-760 | 810-875 | The indocyanine green angiogram |
Be arranged within the light source panel 5 by cold light source 1 and the Lights section that excites filter wheel 2 to form, establish light source switch 11, luminance brightness knob 12, harmonic knob 13 and light delivery outlet 14(on the light source panel 5 as shown in Figure 2), excite filter wheel 2 to be connected with rotating drive link 15, drive link 15 ends are connected (as shown in Figure 3) with harmonic knob 13.
Comprise that the camera part of launching filter wheel 4 is arranged between endoscope eyepiece end 16 and the CCD camera 18, camera part also comprises filter wheel fixed bin 17, emission filter wheel 4 is by the rotating shaft 20 rotatable inside that are installed on filter wheel fixed bin 17, filter wheel fixed bin 17 1 ends are connected with the connector of endoscope eyepiece end 16, and the other end is connected with CCD camera 21.(as Fig. 4, shown in Figure 5)
The optical filter of exciter filter and emission optical filter corresponding specification requires to switch simultaneously, can be by manual, foot-operated remote control and three kinds of modes of hand remote control, foot-operated remote control and hand remote control mode dispose and transmit circuit (as shown in Figure 7) and receive control signal circuit (as shown in Figure 9).
In the time of manually, 17 upper sheds of filter wheel fixed bin, the neighboring part of emission filter wheel 4 is stretched out opening, and the outward flange of emission filter wheel 4 is provided with 1 to No. 7 hole and switches the sign that puts in place.During distance type, also be provided with the motor that is connected and drives its rotation with drive link 15 in the light source panel 5, also be provided with the motor that is connected and drives its rotation with rotating shaft 20 in the filter wheel fixed bin 17.Also dispose telepilot, the radiating circuit that transmits is set in the telepilot, the Lights section and camera part are provided with the reception control circuit 22 that receives remote controller signal and control motor.
Manual switchover is mainly rotated filter wheel by the armstrong's patent mode; The foot control distance type is meant that foot-switch is connected with light source, and control is launched filter wheel and excited filter wheel to switch simultaneously; Manual distance type is meant operating key at operating grip, and control is launched filter wheel and excited filter wheel to switch simultaneously.The hand remote control mode is that remote control buttons is settled on the endoscope pickup camera, the synchronous switching of control light source activation optical filter and camera lens emission optical filter.
Manual switchover, during switching, rotate 13 drives of harmonic knob at the Lights section and excite filter wheel to switch, realize that the spectrum of light delivery outlet 14 switches, rotate emission filter wheel in the filter wheel fixed bin 17, the switching that realizes launching filter wheel and excite filter wheel at endoscope camera part finger.
The foot control distance type switches, and a foot-controlled remote controller is arranged, and interior installation radiating circuit transmits, and the receiving circuit received signal in control the Lights section and the endoscope camera part drives two filter wheels and switches simultaneously.
Manual distance type, the manual distance type of endoscope part joystick structure is installed radiating circuit and is transmitted in the manual telepilot, and the receiving circuit received signal in control the Lights section and the endoscope camera part drives two filter wheels and switches simultaneously.
Optics switched system and endoscope have three kinds of rigid endoscopes of combination: ⑴; ⑵ fibrescope; ⑶ fujinon electronic video endoscope.The treatment scope use the foot control distance type more, can reduce like this operation mirror operation and leak; The diagnosis scope is used manual distance type more, and operation is convenient.The optics switching combines a kind of multispectral endoscope of invention with endoscope, have the comprehensive function of conventional endoscope, autofluorescence endoscope, pigment endoscope, narrow spectrum endoscope, infrared endoscope and near infrared endoscope.
Claims (6)
1. multispectral endoscope optics switched system, it is characterized in that comprising and be arranged at preceding the exciting filter wheel (2) and be arranged at CCD(6 of cold light source (1)) and endoscope emission light between can with the emission filter wheel (4) that excites filter wheel (2) to switch synchronously, excite and have 7 holes on the filter wheel (2), No. 1 hole is a through hole, 2 to No. 7 the hole is provided with exciter filter 2 to No. 7, also have 7 holes on the emission filter wheel (4), No. 1 hole is a through hole, 2 to No. 7 the hole is provided with the emission optical filter 2 to No. 7, the specification such as the following table of described exciter filter and emission optical filter:
The big 50nm of emission optical filter wavelength ratio exciter filter wavelength of corresponding sequence number;
Be arranged within the light source panel (5) by cold light source (1) and the Lights section of exciting filter wheel (2) to form, establish light source switch (11), luminance brightness knob (12), harmonic knob (13) and light delivery outlet (14) on the light source panel (5), excite filter wheel (2) to be connected with rotating drive link (15), drive link (15) end is connected with harmonic knob (13);
The camera part that comprises emission filter wheel (4) is arranged between endoscope eyepiece end (16) and the CCD camera (18), camera part also comprises filter wheel fixed bin (17), emission filter wheel (4) is by the rotatable inside that is installed on filter wheel fixed bin (17) of rotating shaft (20), filter wheel fixed bin (17) one ends are connected with the connector of endoscope eyepiece end (16), and the other end is connected with CCD camera (21).
2. multispectral endoscope optics switched system according to claim 1, it is characterized in that the mode that excites filter wheel (2) and emission filter wheel (4) to switch synchronously is a hand, filter wheel fixed bin (17) upper shed, the neighboring part of emission filter wheel (4) is stretched out opening, and the outward flange of emission filter wheel (4) is provided with 1 to No. 7 hole and switches the sign that puts in place.
3. multispectral endoscope optics switched system according to claim 1, it is characterized in that also being provided with the motor that is connected and drives its rotation with drive link (15) in the light source panel (5), also be provided with the motor that is connected and drives its rotation with rotating shaft (20) in the filter wheel fixed bin (17).
4. multispectral endoscope optics switched system according to claim 3, it is characterized in that the mode that excites filter wheel (2) and emission filter wheel (4) to switch synchronously is a distance type, dispose telepilot, the radiating circuit that transmits is set in the telepilot, and the Lights section and camera part are provided with the reception control circuit (22) that receives remote controller signal and control motor.
5. multispectral endoscope optics switched system according to claim 4 is characterized in that described telepilot is manual telepilot, and the petcock of control radiating circuit is set on it.
6. multispectral endoscope optics switched system according to claim 4 is characterized in that described telepilot is foot-operated telepilot, is provided with the foot-switch of control radiating circuit on it.
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| CN106983495A (en) * | 2017-05-05 | 2017-07-28 | 中国人民武装警察部队总医院 | Multispectral fluorescence imaging system and imaging method based on rigid endoscope |
| CN108030461A (en) * | 2018-01-24 | 2018-05-15 | 梧州奥格森科技有限公司 | A kind of medical endoscope cold light source dual control switching device of optical fiber |
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| CN113454514A (en) * | 2019-02-19 | 2021-09-28 | 富士胶片株式会社 | Endoscope system |
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