CN102056635B - 可生物蚀解的内置假体 - Google Patents
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
Abstract
一种内置假体,其可以包含一个含基底部分和覆盖于基底部分之上的表面部分的主体。所述基底部分可包含基体形式的生物蚀解性金属和在基体中的腐蚀促进沉积物。所述表面部分包含基体的生物蚀解性金属。当暴露于生理环境时表面部分具有第一蚀解速率,并且当暴露于生理环境时基底部分具有大于第一蚀解速率的第二蚀解速率。
Description
技术领域
本发明涉及一种可生物蚀解的内置假体(bioerodible endoprosthesis),更特别地涉及一种可生物蚀解的支架。
背景技术
身体包括多种通道,例如动脉、其它血管,和其它身体内腔。有时这些通道会被堵塞或变弱。例如,通道可被肿瘤堵塞,被斑块狭窄,或由于动脉瘤而变弱。当这些情况发生时,通道可以使用医用内置假体再打开或增强,或甚至替换。内置假体通常为放置在体内的管腔中的管状构件。内置假体的实例包括支架、被覆假体、移植支架和血管闭合销。
内置假体可通过支承内置假体的导管递送到体内,当内置假体转移到所需位置时,其为压缩或缩小尺寸的形式。到达位置后,内置假体膨胀,例如,由此其可以接触到管腔壁。
膨胀机理可以包含迫使所述内置假体径向膨胀。例如,膨胀机理可以包含携带球囊的导管,其携带一个球囊扩张内置假体。球囊能够充气变形并且将膨胀的内置假体固定在与管腔壁接触的预定位置。然后球囊可以放气,导管缩回。
在另一种递送技术中,内置假体由可以可逆压缩和膨胀(例如弹性地或通过材料相变)的弹性材料形成。在导入体内期间,将内置假体控制在压缩状态。当到达所需植入位置时,去掉控制,例如,通过收回限制装置如(外鞘),从而使内置假体通过其本身内部的弹性回复力能够自膨胀。
内置假体能够携带药物,例如抗增殖药物,以减少再狭窄(即,因治疗位置的体内免疫反应而产生的血管再闭合)的可能性。
发明概述
公开的内置假体包含一个含基底部分和覆盖于基底部分之上的表面部分的主体。基底部分包含基体形式的生物蚀解性金属和基体中的腐蚀促进沉积物。表面部分包含基体的生物蚀解性金属。当暴露于生理环境时,表面部分具有第一蚀解速率,并且当暴露于生理环境时基底部分具有大于第一蚀解速率的第二蚀解速率。
腐蚀促进沉积物包含惰性气体(例如,氦气、氩气、氖气、氪气或它们的组合)的纳米气泡。纳米气泡的平均直径可以为1nm至600nm之间。在一些实施方案中,腐蚀促进沉积物可包含银、锰或它们的组合。在其它实施方案中,腐蚀促进沉积物可包含与生物蚀解性金属相同的元素,并通过增强表面张力来提高蚀解速率。在一些实施方案中,腐蚀促进沉积物可比生物蚀解性金属更稀有或不如生物蚀解性金属稀有,并且当腐蚀促进沉积物暴露于生理环境中时,其与生物蚀解性金属形成电偶。在一些实施方案中,腐蚀促进沉积物更加稀有,并且作为阳极以加速生物蚀解性金属的蚀解速率。在其它实施方案中,腐蚀促进沉积物较不稀有,并且比生物蚀解性金属更快腐蚀,并且一旦腐蚀促进沉积物腐蚀掉,使基体材料的表面积增加,其加快生物蚀解性金属的蚀解速率。
表面部分可以基本不具有腐蚀促进沉积物。表面部分的厚度可为0.2微米至3微米之间。在一些实施方案中,表面部分可基本由生物蚀解性金属组成。表面部分可具有基本光滑的上表面。在此使用的术语“基本光滑”要求0.5μm或更小的Ra。
生物蚀解性金属可包含铁或其合金。在其它实施方案中,生物蚀解性金属可包含镁、锌、钨和它们的合金。
内置假体可以为支架。在其它实施方案中,内置假体为血管闭合销。
另一方面,公开了制备内置假体的方法。所述方法包括在包含生物蚀解性金属的主体中注入离子以生成基底部分和覆盖于基底部分之上包含生物蚀解性金属的表面部分,所述基底部分含有在生物蚀解性金属基体中的腐蚀促进沉积物。当暴露在生理环境中时,基底部分具有大于生物蚀解性金属主体表面部分的蚀解速率。
注入的离子可以为,在生物蚀解性金属基体内形成惰性气体纳米气泡的腐蚀促进沉积物的惰性离子和/或与生物蚀解性金属反应产生腐蚀促进沉积物的离子。在一些实施方案中,离子可以使用IBAD或PIII离子注入工艺注入。在一些实施方案中,离子可以小于1×1016个离子/cm2的剂量注入。离子可以至少10keV(例如,在10keV至100keV范围内)的最小能量注入。在一些实施方案中,离子注入工艺期间的温度范围为100℃至500℃之间。在一些实施方案中,温度为生物蚀解性金属熔化温度的0.2倍(例如,对于大多数镁基生物蚀解性合金为100-150℃,对于大多数铁基生物蚀解性合金为200-350℃)。
表面部分可以基本不含腐蚀促进沉积物。在一些实施方案中,在腐蚀促进沉积物注入后,内置假体可包含沉积在表面部分上的其它表面层。
生物蚀解性金属主体可以为支架或支架前体。在其它实施方案中,生物蚀解性金属主体可以为血管闭合销或血管闭合销前体。
下述的附图和描述给出了一个或多个实施方案的详述。其它特征、目的和优点将通过说明书和附图,以及权利要求书显而易见。
附图说明
图1为一个膨胀的支架的实施例的透视图。
图2A-2C描绘了根据不同实施方案的具有植入的离子皮下层的支架枝干的剖面图。
图3描绘了支架支杆的腐蚀曲线图。
图4表述了将离子注入到支架的示例性环境。
不同附图中相同的附图标记代表相同的部分。
发明详述
参照图1,支架20具有由多个支杆所限定的管状构件的形式。支杆可包含多个带22和多个延伸并连接在相邻的带之间的连接体24。使用时,带22可以从最初的小直径膨胀到较大直径以使支架20接触血管壁,从而保持血管开放。连接体24可以为支架20提供柔韧性和适应性,从而使支架适应血管的外形。
支架包含生物蚀解性金属。生物蚀解性金属的实例包括铁、镁、钨、锌以及它们的合金。例如,生物蚀解性金属可以为生物蚀解铁合金,其包含最高达20%的锰,最高达10%的银以及最高达5%的碳。生物蚀解性金属还可以是一种生物蚀解性镁合金,其包括最高达9%的铝、最高达5%的稀土金属、最高达5%的锌、最高达5%的锂、最高达5%的锰、最高达10%的银、最高达5%的铬、最高达5%的硅、最高达5%的锡、最高达6%的钇以及最高达10%的锌。合适的镁生物蚀解性合金包含ZK31,其包含3%的锌和1%的锆,ZK61,其包含6%的锌和1%的锆,AZ31,其包含3%的铝和1%的锌,AZ91,其包含9%的铝和1%的锌,WE43,其包含4%的钇和3%的稀土金属,和WE54,其包含5%的钇和4%的稀土金属。包含生物蚀解性金属的支架可以再打开和/或增强体内通道,还可以在超过时间后分解从而在治疗过程完毕之后使支架不再存在于身体通道之内。当暴露于生理环境中时,不同的生物蚀解性金属和支架支杆结构体可具有不同的蚀解速率。相应地,支架可以基于支架支杆的蚀解特性设计以在所需时间内保持所需结构性质。
如附图2A-2C所示,支架支杆(例如,带22和/或连接体24)包括一个表面部分32和一个基底部分34。在一些实施方案中,如附图2A所示,基底部分34可以沿着支架支杆的周边分布。在其它实施方案中,如附图2B和2C所示,基底部分34沿着支架支杆的所选侧,例如沿着支架的内径和/或外径分布。在一些实施方案中,如附图2C所示,支架支杆可具有沿着支架支杆外径分布的基底部分34和沿着内径分布的其它涂层38。
表面部分32覆盖在基底部分34上。表面部分32包含生物蚀解性金属,而基底部分34包含在生物蚀解性金属基体中的腐蚀促进沉积物28。当植入生理环境中时,表面部分32以第一速率得以蚀解。当表面部分蚀解至将基底部分暴露在生理环境中时,基底部分34以快于第一速率的第二速率得以蚀解。该蚀解曲线的实例描述于图3中。如所示的,支架的厚度随时间的消逝而减少。在最初的蚀解期42内,表面部分32以第一速率得以蚀解。在这个最初的蚀解期42内,生物蚀解支架提供了机械支撑功能。一旦表面部分32蚀解掉之后使基底部分34暴露于生理环境中,由于生物蚀解性金属基体中的腐蚀促进沉积物28的存在,可以产生加快的蚀解期44。通过具有慢于第二蚀解速率的第一蚀解速率的支架,支架支杆可以设计成比具有恒定蚀解速率的支架更小的原始尺寸,因为在最初蚀解期42中第一蚀解速率保护了最初治疗过程中支架的机械性能。然后加快的蚀解期44减少了削弱后的支架支杆在体内通道中存在的时间。
表面部分32的厚度可为0.1微米至3微米之间。表面部分32包括一个基本光滑的上表面。在此使用的术语“基本光滑”要求0.5μm或更小的Ra。表面部分32可以包含与包含于基底部分的生物蚀解性金属相同的生物蚀解性金属。表面部分32可以基本不含有任何腐蚀促进沉积物28。在一些实施方案中,表面部分32可以基本不含除了生物蚀解性金属之外的其它成分。在一些实施方案中,支架20可以包含在腐蚀促进沉积物沉积后沉积的其它表面层。例如,其它表面层可以通过由蒸汽沉积或脉冲激光沉积工艺,在表面部分32上沉积生物蚀解性金属形成。这些其它表面层的厚度为10微米或更大。
基底部分34包含腐蚀促进沉积物28。在一些实施方案中,基底部分的厚度可至少为1微米。在一些实施方案中,厚度为2微米至3微米之间。腐蚀促进沉积物28可以通过采用在基底部分注入离子而使表面部分基本不具有腐蚀促进沉积物28的能量注入离子而置于基底部分中。注入时离子的能级决定了注入的深度。例如,腐蚀促进沉积物28可以通过10keV的最小能量注入离子而产生。在一些实施方案中,离子可以在10keV至100keV之间的能量范围内注入。表面部分32和基底部分34的厚度可以通过注入离子所用的能量范围来确定。基底部分的厚度和深度也部分取决于生物蚀解性金属中包埋离子的扩散。包埋的离子可以产生垂直于表面的压力梯度,其迫使离子进一步进入支架支杆。该压力梯度能够迫使离子进一步进入生物降解材料。注入离子以形成腐蚀促进沉积物可以通过在每个腐蚀促进沉积物28周围产生高应力区域和/或压缩区域来提高基底部分34的蚀解速率。在一些实施方案中,可以使用离子束辅助沉积技术(“IBAD”)或等离子体浸没离子注入技术(“PIII”)注入离子。在一些实施方案中,离子注入工艺中的温度范围为100℃至500℃之间。在一些实施方案中,该温度约为生物蚀解性金属熔解温度的0.2倍(例如,对于大多数镁基生物蚀解性合金为100-150℃,对于大多数铁基生物蚀解性合金为200-350℃)。
图4举例说明了进行PIII的典型环境。为了进行PIII,将支架20的前体插入室体50中。支架20的前体包含一种生物蚀解性金属(例如,市售纯铁)。室体50是由含有等离子体56的真空54产生的真空室。等离子体56含有待注入支架20以形成腐蚀促进沉积物28的离子。支架20的前体使用脉冲发生器58产生的负电压重复脉冲。负电压脉冲导致电子从支架20中排斥出,而阳离子60被吸引到带负电荷的支架20上。因此,阳离子将撞击支架20的所有表面,并且被包埋入支架20和/或沉积到支架20上。
腐蚀促进沉积物28可以包含惰性气体的纳米气泡。惰性气体的纳米气泡可以通过增加生物蚀解性金属的表面积而提高生物蚀解性金属的蚀解速率。惰性气体的纳米气泡可以通过注入惰性气体离子而形成于生物蚀解性金属的基体之中。例如,腐蚀促进沉积物28可以包含氦气、氩气、氖气和/或氪气的纳米气泡。纳米气泡的平均直径可在1nm至600nm之间。当注入惰性气体离子以在基底部分34中产生惰性气体的纳米气泡时,可以控制剂量以防止纳米气泡迁移到表面部分32。在一些实施方案中,惰性气体离子的剂量保持在小于1×1016个离子/cm2。
腐蚀促进沉积物28可以包含加速腐蚀解过程的固体材料。例如,可以注入离子与生物蚀解性金属反应或形成合金以形成腐蚀促进沉积物28。例如,腐蚀促进沉积物可以包含银、铜和/或锰。在其它实施方案中,腐蚀促进沉积物可以包含与生物蚀解性金属相同的元素,并且通过增强表面张力来提高增加蚀解速率。在一些实施方案中,得到的腐蚀促进沉积物28可以通过在暴露于生理环境中时从剩余基体中分离,以而提高增加基底部分34的蚀解速率。在一些实施方案中,腐蚀促进沉积物或多或少的比可比生物蚀解性金属更稀有或更不稀有,并且当腐蚀促进沉积物暴露于生理环境中时,其与生物蚀解性金属形成电偶。在一些实施方案中,腐蚀促进沉积物更加稀有,并且作为阳极(anode)以加速提高生物蚀解性金属的蚀解速率。在其它实施方案中,腐蚀促进沉积物较不稀有,并且比生物蚀解性金属腐蚀解得更的快,从而当腐蚀促进沉积物腐蚀解掉之后,在基体材料上增加大表面积,以加速提高生物蚀解性金属的蚀解速率。例如,银和铜可以形成电偶,从而加速铁的腐蚀。
在一些实施方案中,腐蚀促进沉积物28可以不渗透进入支架支杆的中心部分36。如图3所示,当含有腐蚀促进沉积物28的基底部分蚀解后,剩余的支架支杆可在大量蚀解期(bulk erosion period)46中继续得以蚀解。由于因支架蚀解的变化而导致的支架支杆表面积增加,大量蚀解期46中的蚀解速率可以慢于加速蚀解期44中的蚀解速率,但是快于最初蚀解期42中的蚀解速率。
支架20可以是任意所需形状和尺寸(例如,股浅动脉支架、冠状动脉支架、大动脉支架、外周血管支架、胃肠支架、泌尿支架和神经支架)。根据应用,支架直径可以为例如1mm至46mm之间。在特定实施方案中,冠状动脉支架的膨胀后直径可以为2mm至6mm之间。在一些实施方案中,外周血管支架的膨胀后直径可以为5mm至24mm之间。在某些实施方案中,胃肠支架和/或泌尿支架的膨胀后直径可以为6mm至大约30mm之间。在一些实施方案中,神经支架的膨胀后直径可以为大约1毫米至大约12mm之间。腹主动脉瘤(AAA)支架和胸主动脉瘤(TAA)支架的直径可以为大约20mm至大约46mm之间。
支架20可包含一个或多个包含表面部分32和基底部分34的支杆。在一些实施方案中,支架可以为完全生物降蚀解的。在其它实施方案中,支架可以包括生物降蚀解性和非生物降蚀解性部分。在一些实施方案中,支架20可以包含选择处理各种带22和/或连接体24的选择性处理,以产生在预定区域和预定式样中以较快速率腐蚀解的支架,以从而控制支架的整体腐蚀解过程。。例如,连接体24的优先腐蚀解可以减少带22中的应力。优先腐蚀解区域可以通过如下方式产生:使不同区域具有不同含量和/或类型的腐蚀促进沉积物28,或者通过使不同区域具有不同表面部分厚度,和/或通使一些部分过缺少腐蚀促进沉积物28。
在某些实施方案中,支架20可适于释放一种或多种治疗剂。术语“治疗剂”包含一种或多种“治疗剂”或“药物”。术语“治疗剂”或“药物”互换使用,并且包括药物活性化合物,具有或不具有载体媒介(例如脂类)的核酸,致密剂(例如组蛋白),病毒(例如腺病毒,腺伴随病毒,逆转录病毒,慢病毒和a-病毒),聚合物,抗生素,透明质酸,基因治疗剂,蛋白质,细胞,干细胞等,或它们的组合,具有或不具有导向序列。由于需要保持细胞功能和活性配制介导的传递。常见的治疗剂实例包含紫杉醇(Paclitaxel)。
在一些实施方案中,支架20还包含覆盖于表面部分32之上的一个或多个涂层。在一些实施方案中,表面涂层可以进一步延缓表面部分32的蚀解。在一些实施方案中,涂层可以为包含治疗剂的药物释放涂层。
支架20使用导管传递系统而使用,例如传递和膨胀。在例如WangU.S.5,195,969,Hamlin U.S.5,270,086,和Raeder-Devens,U.S.6,726,712中描述了导管系统。支架和支架传递还以从波士顿科学公司(BostonScientific Scimed,槭树林(Maple Grove),MN)得到的系统为代表。
在一些实施方案中,支架还可以为被覆支架或移植支架中的一部分。在其它实施方案中,支架可以包含和/或连接到生物相容的,无孔或半孔的聚合物基体上,所述聚合物基体由聚四氟乙烯(PTFE),膨胀PTEF,聚乙烯,氨基甲酸乙酯或聚丙烯制成。
在一些实施方案中,支架可以通过制备具有覆盖于基底部分之上的表面部分的丝(所述基底部分包含腐蚀促进沉积物),并且编结和/或编织所述丝成管状构件得到。
在此涉及的所有出版物、参考文献、申请和专利全部引入本文作为参考。
其它实施方案包括在权利要求书中。
Claims (13)
1.一种内置假体,其包含由多个支杆所限定的管状构件,所述支杆包含:
(a)中心部分,它沿着所述支杆纵向延伸,该中心部分不含腐蚀促进沉积物;
(b)基底部分,其包含基体形式的生物蚀解性金属和基体中的腐蚀促进沉积物,该基底部分相对于所述中心部分径向向外延伸,该基底部分的厚度至少为1微米;和
(b)表面部分,其厚度为0.1-3微米,其覆盖在基底部分之上并相对于所述中心部分由所述基底部分径向向外延伸,该表面部分包含基体的生物蚀解性金属并基本不含腐蚀促进沉积物;
当暴露于生理环境时,所述表面部分具有第一蚀解速率,且当暴露于生理环境时,所述基底部分具有大于第一蚀解速率的第二蚀解速率。
2.如权利要求1所述的内置假体,其特征在于,所述腐蚀促进沉积物包含惰性气体的纳米气泡。
3.如权利要求2所述的内置假体,其特征在于,所述纳米气泡包含氦气、氩气、氖气、氪气或它们的组合。
4.如权利要求2所述的内置假体,其特征在于,所述纳米气泡的平均直径为1nm至600nm之间。
5.如权利要求1所述的内置假体,其特征在于,所述腐蚀促进沉积物包含银。
6.如权利要求1所述的内置假体,其特征在于,所述腐蚀促进沉积物包含锰。
7.如权利要求1所述的内置假体,其特征在于,所述腐蚀促进沉积物比所述生物蚀解性金属更稀有,当所述腐蚀促进沉积物暴露于生理环境中时,其与所述生物蚀解性金属形成电偶,并且所述腐蚀促进沉积物作为阳极。
8.如权利要求1所述的内置假体,其特征在于,所述腐蚀促进沉积物比所述生物蚀解性金属更不稀有,当所述腐蚀促进沉积物暴露于生理环境中时,其与所述生物蚀解性金属形成电偶,并且所述腐蚀促进沉积物作为阴极。
9.如权利要求1所述的内置假体,其特征在于,所述表面部分基本由生物蚀解性金属组成。
10.如权利要求1所述的内置假体,其特征在于,所述表面部分具有基本光滑的上表面。
11.如权利要求1所述的内置假体,其特征在于,生物蚀解性金属包含铁或其合金。
12.如权利要求1所述的内置假体,其特征在于,所述内置假体是支架。
13.如权利要求1所述的内置假体,其特征在于,所述基底部分的厚度为2-3微米。
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Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10028851B2 (en) * | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
US7713297B2 (en) | 1998-04-11 | 2010-05-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US8458879B2 (en) * | 2001-07-03 | 2013-06-11 | Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. | Method of fabricating an implantable medical device |
US7727221B2 (en) | 2001-06-27 | 2010-06-01 | Cardiac Pacemakers Inc. | Method and device for electrochemical formation of therapeutic species in vivo |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US20070224235A1 (en) | 2006-03-24 | 2007-09-27 | Barron Tenney | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
CA2655793A1 (en) | 2006-06-29 | 2008-01-03 | Boston Scientific Limited | Medical devices with selective coating |
JP2009545407A (ja) | 2006-08-02 | 2009-12-24 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 三次元分解制御を備えたエンドプロテーゼ |
JP2010503469A (ja) | 2006-09-14 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 薬物溶出性皮膜を有する医療デバイス |
JP2010503489A (ja) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 生体内分解性内部人工器官およびその製造方法 |
WO2008034066A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making the same |
WO2008034013A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices and methods of making the same |
DE602007011114D1 (de) * | 2006-09-15 | 2011-01-20 | Boston Scient Scimed Inc | Biologisch erodierbare endoprothese mit biostabilen anorganischen schichten |
WO2008036548A2 (en) | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Endoprostheses |
US7981150B2 (en) * | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
ES2506144T3 (es) | 2006-12-28 | 2014-10-13 | Boston Scientific Limited | Endoprótesis bioerosionables y procedimiento de fabricación de las mismas |
US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
WO2009012353A2 (en) | 2007-07-19 | 2009-01-22 | Boston Scientific Limited | Endoprosthesis having a non-fouling surface |
US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
WO2009018340A2 (en) | 2007-07-31 | 2009-02-05 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
JP2010535541A (ja) | 2007-08-03 | 2010-11-25 | ボストン サイエンティフィック リミテッド | 広い表面積を有する医療器具用のコーティング |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8118857B2 (en) | 2007-11-29 | 2012-02-21 | Boston Scientific Corporation | Medical articles that stimulate endothelial cell migration |
EP2271380B1 (en) | 2008-04-22 | 2013-03-20 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
WO2009132176A2 (en) | 2008-04-24 | 2009-10-29 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
EP2303350A2 (en) | 2008-06-18 | 2011-04-06 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
EP2403546A2 (en) | 2009-03-02 | 2012-01-11 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
EP2470257B1 (en) | 2009-08-27 | 2015-03-04 | Silver Bullet Therapeutics Inc. | Bone implants for the treatment of infection |
US9821094B2 (en) | 2014-06-11 | 2017-11-21 | Silver Bullet Therapeutics, Inc. | Coatings for the controllable release of antimicrobial metal ions |
US10265435B2 (en) | 2009-08-27 | 2019-04-23 | Silver Bullet Therapeutics, Inc. | Bone implant and systems and coatings for the controllable release of antimicrobial metal ions |
US8927004B1 (en) | 2014-06-11 | 2015-01-06 | Silver Bullet Therapeutics, Inc. | Bioabsorbable substrates and systems that controllably release antimicrobial metal ions |
US9114197B1 (en) | 2014-06-11 | 2015-08-25 | Silver Bullett Therapeutics, Inc. | Coatings for the controllable release of antimicrobial metal ions |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
WO2012064402A1 (en) | 2010-11-12 | 2012-05-18 | Silver Bullet Therapeutics, Inc. | Bone implant and systems that controllably releases silver |
GB201116879D0 (en) * | 2011-09-30 | 2011-11-16 | Magnus Stent Ic | Endoprosthesis |
US20130090741A1 (en) * | 2011-10-07 | 2013-04-11 | Medtronic Vascular, Inc. | Magnesium Alloys for Bioabsorbable Stent |
US10028847B2 (en) | 2012-05-02 | 2018-07-24 | Les Enterprises Nanostent Inc. | Bioresorbable medical devices and method of manufacturing the same |
US10736995B2 (en) | 2012-05-02 | 2020-08-11 | Les Entreprises Nanostent Inc. | Bioresorbable medical devices and method of manufacturing the same |
JP6392250B2 (ja) | 2013-02-15 | 2018-09-19 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 生体内分解性の内部人工器官およびそれに使用する生体内分解性マグネシウム合金を加工する方法 |
JP2016105750A (ja) * | 2013-04-05 | 2016-06-16 | テルモ株式会社 | ガルバニック腐食ステント |
US9320628B2 (en) | 2013-09-09 | 2016-04-26 | Boston Scientific Scimed, Inc. | Endoprosthesis devices including biostable and bioabsorable regions |
WO2015066181A1 (en) | 2013-10-29 | 2015-05-07 | Boston Scientific Scimed, Inc. | Bioerodible magnesium alloy microstructures for endoprostheses |
CN105722474B (zh) | 2013-11-13 | 2018-09-21 | 柯惠有限合伙公司 | 以原电池方式辅助医疗装置与血栓的附着 |
JP6346765B2 (ja) * | 2014-03-24 | 2018-06-20 | テルモ株式会社 | ステント |
EP3128960A1 (en) | 2014-04-08 | 2017-02-15 | Boston Scientific Scimed, Inc. | Partially coated stents |
US9452242B2 (en) | 2014-06-11 | 2016-09-27 | Silver Bullet Therapeutics, Inc. | Enhancement of antimicrobial silver, silver coatings, or silver platings |
US11274362B2 (en) | 2014-08-29 | 2022-03-15 | Toufic Azar | Bioresorbable materials, bioresorbable medical devices, bioresorbable coatings for implantable medical devices and method of manufacturing the same using vapor deposition |
KR102250190B1 (ko) * | 2014-10-31 | 2021-05-10 | 삼성전자주식회사 | 나노버블을 가진 그래핀 구조체 및 그 제조방법 |
CA2973155A1 (en) | 2015-03-11 | 2016-09-15 | Boston Scientific Scimed, Inc. | Bioerodible magnesium alloy microstructures for endoprostheses |
US10265515B2 (en) | 2015-03-27 | 2019-04-23 | Covidien Lp | Galvanically assisted aneurysm treatment |
EP3542737B1 (en) | 2015-09-25 | 2021-06-16 | Covidien LP | Medical device delivery system |
CN107648676A (zh) * | 2017-11-08 | 2018-02-02 | 谭思暄 | 一种可降解铁基心血管支架材料及其制备方法 |
US10512495B2 (en) | 2017-12-28 | 2019-12-24 | Industrial Technology Research Institute | Method for fabricating medical device and applications thereof |
CN111329632B (zh) * | 2018-12-19 | 2021-10-22 | 元心科技(深圳)有限公司 | 可吸收金属支架 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7261734B2 (en) * | 2002-04-23 | 2007-08-28 | Boston Scientific Scimed, Inc. | Resorption-controllable medical implants |
Family Cites Families (1129)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060A (en) * | 1858-04-27 | Pump-couplingr | ||
US673071A (en) * | 1901-01-24 | 1901-04-30 | Alfred Adamson | Reversing-gear for motor-vehicles. |
US2950187A (en) | 1958-09-05 | 1960-08-23 | Res Inst Iron Steel | Iron-calcium base alloy |
US3560362A (en) * | 1966-08-03 | 1971-02-02 | Japan Atomic Energy Res Inst | Method and apparatus for promoting chemical reactions by means of radioactive inert gases |
US3569660A (en) * | 1968-07-29 | 1971-03-09 | Nat Res Dev | Laser cutting apparatus |
GB1237035A (en) | 1969-08-20 | 1971-06-30 | Tsi Travmatologii I Ortopedii | Magnesium-base alloy for use in bone surgery |
US3758396A (en) | 1971-08-31 | 1973-09-11 | Research Corp | Ition preparation of immobilized enzymemembrane complexes by electrocodepos |
US3948254A (en) | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
US3868578A (en) | 1972-10-02 | 1975-02-25 | Canadian Patents Dev | Method and apparatus for electroanalysis |
US3910819A (en) | 1974-02-19 | 1975-10-07 | California Inst Of Techn | Treatment of surfaces to stimulate biological cell adhesion and growth |
US3993072A (en) | 1974-08-28 | 1976-11-23 | Alza Corporation | Microporous drug delivery device |
US3952334A (en) | 1974-11-29 | 1976-04-27 | General Atomic Company | Biocompatible carbon prosthetic devices |
US4002877A (en) * | 1974-12-13 | 1977-01-11 | United Technologies Corporation | Method of cutting with laser radiation and liquid coolant |
US4101984A (en) | 1975-05-09 | 1978-07-25 | Macgregor David C | Cardiovascular prosthetic devices and implants with porous systems |
DE2620907C3 (de) | 1976-05-12 | 1984-09-20 | Battelle-Institut E.V., 6000 Frankfurt | Verankerung für hochbelastete Endoprothesen |
US4143661A (en) | 1977-12-12 | 1979-03-13 | Andros Incorporated | Power supply for body implant and method for operation |
DE2827529C2 (de) | 1978-06-23 | 1982-09-30 | Battelle-Institut E.V., 6000 Frankfurt | Implantierbarer Knochenersatzwerkstoff bestehend aus einem Metallkern und aus bioaktiven, gesinterten Calciumphosphat-Keramik-Partikeln und ein Verfahren zu seiner Herstellung |
US4713070A (en) | 1978-11-30 | 1987-12-15 | Sumitom Electric Industries, Ltd. | Porous structure of polytetrafluoroethylene and process for production thereof |
US4237559A (en) | 1979-05-11 | 1980-12-09 | General Electric Company | Bone implant embodying a composite high and low density fired ceramic construction |
US4334327A (en) | 1979-12-21 | 1982-06-15 | University Of Utah | Ureteral prosthesis |
US4308868A (en) | 1980-05-27 | 1982-01-05 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Implantable electrical device |
CH649578A5 (de) | 1981-03-27 | 1985-05-31 | Ulvac Corp | Hochgeschwindigkeits-kathoden-zerstaeubungsvorrichtung. |
US4542539A (en) | 1982-03-12 | 1985-09-24 | Artech Corp. | Surgical implant having a graded porous coating |
SE445884B (sv) | 1982-04-30 | 1986-07-28 | Medinvent Sa | Anordning for implantation av en rorformig protes |
US4539061A (en) | 1983-09-07 | 1985-09-03 | Yeda Research And Development Co., Ltd. | Process for the production of built-up films by the stepwise adsorption of individual monolayers |
US4657544A (en) | 1984-04-18 | 1987-04-14 | Cordis Corporation | Cardiovascular graft and method of forming same |
US5938903A (en) | 1984-05-09 | 1999-08-17 | Research Foundation Of The City University Of New York | Microelectrodes and their use in an electrochemical arrangement with telemetric application |
US4532929A (en) | 1984-07-23 | 1985-08-06 | Ethicon, Inc. | Dry coating of surgical filaments |
US4634502A (en) | 1984-11-02 | 1987-01-06 | The Standard Oil Company | Process for the reductive deposition of polyoxometallates |
US4585652A (en) | 1984-11-19 | 1986-04-29 | Regents Of The University Of Minnesota | Electrochemical controlled release drug delivery system |
US4665896A (en) | 1985-07-22 | 1987-05-19 | Novacor Medical Corporation | Power supply for body implant and method of use |
DE3682734D1 (de) * | 1985-08-23 | 1992-01-16 | Kanegafuchi Chemical Ind | Kuenstliches gefaess. |
US4705502A (en) | 1985-11-06 | 1987-11-10 | The Kendall Company | Suprapubic catheter with dual balloons |
US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
US4767418A (en) | 1986-02-13 | 1988-08-30 | California Institute Of Technology | Luminal surface fabrication for cardiovascular prostheses |
DE3608158A1 (de) | 1986-03-12 | 1987-09-17 | Braun Melsungen Ag | Mit vernetzter gelatine impraegnierte gefaessprothese und verfahren zu ihrer herstellung |
SE453258B (sv) | 1986-04-21 | 1988-01-25 | Medinvent Sa | Elastisk, sjelvexpanderande protes samt forfarande for dess framstellning |
CH670760A5 (zh) * | 1986-06-02 | 1989-07-14 | Sulzer Ag | |
US4800882A (en) | 1987-03-13 | 1989-01-31 | Cook Incorporated | Endovascular stent and delivery system |
US4827940A (en) | 1987-04-13 | 1989-05-09 | Cardiac Pacemakers, Inc. | Soluble covering for cardiac pacing electrode |
US5527337A (en) | 1987-06-25 | 1996-06-18 | Duke University | Bioabsorbable stent and method of making the same |
US5059211A (en) | 1987-06-25 | 1991-10-22 | Duke University | Absorbable vascular stent |
US4886062A (en) | 1987-10-19 | 1989-12-12 | Medtronic, Inc. | Intravascular radially expandable stent and method of implant |
US5024671A (en) | 1988-09-19 | 1991-06-18 | Baxter International Inc. | Microporous vascular graft |
US5091205A (en) | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
CH678393A5 (zh) | 1989-01-26 | 1991-09-13 | Ulrich Prof Dr Med Sigwart | |
US5163958A (en) | 1989-02-02 | 1992-11-17 | Cordis Corporation | Carbon coated tubular endoprosthesis |
US4994071A (en) | 1989-05-22 | 1991-02-19 | Cordis Corporation | Bifurcating stent apparatus and method |
US5073365A (en) | 1989-06-01 | 1991-12-17 | Advanced Polymer Systems | Clinical and personal care articles enhanced by lubricants and adjuvants |
US5061914A (en) | 1989-06-27 | 1991-10-29 | Tini Alloy Company | Shape-memory alloy micro-actuator |
EP0405556B1 (en) | 1989-06-30 | 1996-05-22 | TDK Corporation | Living hard tissue replacement, its preparation, and preparation of integral body |
US5091024A (en) | 1989-07-13 | 1992-02-25 | Carpenter Technology Corporation | Corrosion resistant, magnetic alloy article |
US5647858A (en) | 1989-07-25 | 1997-07-15 | Smith & Nephew, Inc. | Zirconium oxide and zirconium nitride coated catheters |
DE69002295T2 (de) | 1989-09-25 | 1993-11-04 | Schneider Usa Inc | Mehrschichtextrusion als verfahren zur herstellung von ballons zur gefaessplastik. |
US5843089A (en) | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
US5439446A (en) | 1994-06-30 | 1995-08-08 | Boston Scientific Corporation | Stent and therapeutic delivery system |
US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5477864A (en) | 1989-12-21 | 1995-12-26 | Smith & Nephew Richards, Inc. | Cardiovascular guidewire of enhanced biocompatibility |
US5545208A (en) | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5236413B1 (en) | 1990-05-07 | 1996-06-18 | Andrew J Feiring | Method and apparatus for inducing the permeation of medication into internal tissue |
DE69016433T2 (de) | 1990-05-19 | 1995-07-20 | Papyrin Anatolij Nikiforovic | Beschichtungsverfahren und -vorrichtung. |
US5079203A (en) | 1990-05-25 | 1992-01-07 | Board Of Trustees Operating Michigan State University | Polyoxometalate intercalated layered double hydroxides |
US5587507A (en) | 1995-03-31 | 1996-12-24 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
US5120322A (en) | 1990-06-13 | 1992-06-09 | Lathrotec, Inc. | Method and apparatus for treatment of fibrotic lesions |
US5102403A (en) | 1990-06-18 | 1992-04-07 | Eckhard Alt | Therapeutic medical instrument for insertion into body |
US5236447A (en) | 1990-06-29 | 1993-08-17 | Nissho Corporation | Artificial tubular organ |
US5549664A (en) | 1990-07-31 | 1996-08-27 | Ube Industries, Ltd. | Artificial blood vessel |
US4976692A (en) | 1990-09-13 | 1990-12-11 | Travenol Laboratories (Israel) Ltd. | Catheter particularly useful for inducing labor and/or for the application of a pharmaceutical substance to the cervix of the uterus |
US5160790A (en) | 1990-11-01 | 1992-11-03 | C. R. Bard, Inc. | Lubricious hydrogel coatings |
US6524274B1 (en) | 1990-12-28 | 2003-02-25 | Scimed Life Systems, Inc. | Triggered release hydrogel drug delivery system |
US5205921A (en) | 1991-02-04 | 1993-04-27 | Queen's University At Kingston | Method for depositing bioactive coatings on conductive substrates |
DE4104359A1 (de) | 1991-02-13 | 1992-08-20 | Implex Gmbh | Ladesystem fuer implantierbare hoerhilfen und tinnitus-maskierer |
USRE38653E1 (en) | 1991-03-08 | 2004-11-16 | Kabushikikaisha Igaki Iryo Sekkei | Luminal stent, holding structure therefor and device for attaching luminal stent |
US5195969A (en) | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US5147370A (en) | 1991-06-12 | 1992-09-15 | Mcnamara Thomas O | Nitinol stent for hollow body conduits |
US5258098A (en) | 1991-06-17 | 1993-11-02 | Cycam, Inc. | Method of production of a surface adapted to promote adhesion |
US5292558A (en) | 1991-08-08 | 1994-03-08 | University Of Texas At Austin, Texas | Process for metal deposition for microelectronic interconnections |
US5356433A (en) | 1991-08-13 | 1994-10-18 | Cordis Corporation | Biocompatible metal surfaces |
US6107004A (en) | 1991-09-05 | 2000-08-22 | Intra Therapeutics, Inc. | Method for making a tubular stent for use in medical applications |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5500013A (en) | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5464450A (en) | 1991-10-04 | 1995-11-07 | Scimed Lifesystems Inc. | Biodegradable drug delivery vascular stent |
WO1993006792A1 (en) | 1991-10-04 | 1993-04-15 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5366504A (en) | 1992-05-20 | 1994-11-22 | Boston Scientific Corporation | Tubular medical prosthesis |
US5234457A (en) | 1991-10-09 | 1993-08-10 | Boston Scientific Corporation | Impregnated stent |
WO1993007924A1 (en) | 1991-10-18 | 1993-04-29 | Spire Corporation | Bactericidal coatings for implants |
JP2961287B2 (ja) | 1991-10-18 | 1999-10-12 | グンゼ株式会社 | 生体管路拡張具、その製造方法およびステント |
CA2079417C (en) | 1991-10-28 | 2003-01-07 | Lilip Lau | Expandable stents and method of making same |
US5314453A (en) | 1991-12-06 | 1994-05-24 | Spinal Cord Society | Position sensitive power transfer antenna |
EP0791333B1 (en) | 1991-12-12 | 1999-12-01 | Target Therapeutics, Inc. | Detachable pusher-vasoocclusive coil assembly with interlocking coupling |
US5193540A (en) | 1991-12-18 | 1993-03-16 | Alfred E. Mann Foundation For Scientific Research | Structure and method of manufacture of an implantable microstimulator |
US5348553A (en) | 1991-12-18 | 1994-09-20 | Whitney Douglass G | Method for promoting blood vessel healing |
US5360440A (en) | 1992-03-09 | 1994-11-01 | Boston Scientific Corporation | In situ apparatus for generating an electrical current in a biological environment |
EP0566245B1 (en) | 1992-03-19 | 1999-10-06 | Medtronic, Inc. | Intraluminal stent |
US5599352A (en) | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
US5282823A (en) | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
US5591224A (en) | 1992-03-19 | 1997-01-07 | Medtronic, Inc. | Bioelastomeric stent |
US5779904A (en) | 1992-03-31 | 1998-07-14 | Inrad | Synthesis of inorganic membranes on supports |
JPH07505316A (ja) | 1992-03-31 | 1995-06-15 | ボストン サイエンティフィック コーポレーション | 医療用ワイヤ |
GEP20002074B (en) * | 1992-05-19 | 2000-05-10 | Westaim Tech Inc Ca | Modified Material and Method for its Production |
CA2074318A1 (en) | 1992-07-22 | 1994-01-23 | Morteza Shirkhanzadeh | Prosthetic implant with self-generated current for early fixation in skeletal bone |
US5614549A (en) | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5447533A (en) | 1992-09-03 | 1995-09-05 | Pacesetter, Inc. | Implantable stimulation lead having an advanceable therapeutic drug delivery system |
JP3739411B2 (ja) | 1992-09-08 | 2006-01-25 | 敬二 伊垣 | 脈管ステント及びその製造方法並びに脈管ステント装置 |
US5458627A (en) | 1992-10-15 | 1995-10-17 | Electro-Biology, Inc. | Electrochemically controlled faradic stimulation of osteogenesis |
US5449382A (en) | 1992-11-04 | 1995-09-12 | Dayton; Michael P. | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5578075B1 (en) | 1992-11-04 | 2000-02-08 | Daynke Res Inc | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5322520A (en) | 1992-11-12 | 1994-06-21 | Implemed, Inc. | Iontophoretic structure for medical devices |
US5385776A (en) | 1992-11-16 | 1995-01-31 | Alliedsignal Inc. | Nanocomposites of gamma phase polymers containing inorganic particulate material |
US5342348A (en) | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
US5443458A (en) | 1992-12-22 | 1995-08-22 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method of manufacture |
ES2166370T3 (es) | 1993-01-19 | 2002-04-16 | Schneider Usa Inc | Filamento implantable en material compuesto. |
US5607463A (en) | 1993-03-30 | 1997-03-04 | Medtronic, Inc. | Intravascular medical device |
US5380298A (en) | 1993-04-07 | 1995-01-10 | The United States Of America As Represented By The Secretary Of The Navy | Medical device with infection preventing feature |
US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5824048A (en) | 1993-04-26 | 1998-10-20 | Medtronic, Inc. | Method for delivering a therapeutic substance to a body lumen |
US5518767A (en) | 1993-07-01 | 1996-05-21 | Massachusetts Institute Of Technology | Molecular self-assembly of electrically conductive polymers |
US20030203976A1 (en) | 1993-07-19 | 2003-10-30 | William L. Hunter | Anti-angiogenic compositions and methods of use |
US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
ES2157977T3 (es) | 1993-07-23 | 2001-09-01 | Cook Inc | Sonda flexible que tiene una configuracion conformada a partir de una hoja de material. |
US6776094B1 (en) | 1993-10-04 | 2004-08-17 | President & Fellows Of Harvard College | Kit For Microcontact Printing |
US5776748A (en) | 1993-10-04 | 1998-07-07 | President And Fellows Of Harvard College | Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor |
US6176874B1 (en) | 1993-10-18 | 2001-01-23 | Masschusetts Institute Of Technology | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques |
US5721049A (en) * | 1993-11-15 | 1998-02-24 | Trustees Of The University Of Pennsylvania | Composite materials using bone bioactive glass and ceramic fibers |
US5397307A (en) | 1993-12-07 | 1995-03-14 | Schneider (Usa) Inc. | Drug delivery PTCA catheter and method for drug delivery |
US5462575A (en) | 1993-12-23 | 1995-10-31 | Crs Holding, Inc. | Co-Cr-Mo powder metallurgy articles and process for their manufacture |
US5788687A (en) | 1994-02-01 | 1998-08-04 | Caphco, Inc | Compositions and devices for controlled release of active ingredients |
US5449373A (en) | 1994-03-17 | 1995-09-12 | Medinol Ltd. | Articulated stent |
JPH07257079A (ja) | 1994-03-25 | 1995-10-09 | Dainippon Printing Co Ltd | 光カード |
ATE310839T1 (de) | 1994-04-29 | 2005-12-15 | Scimed Life Systems Inc | Stent mit kollagen |
US5468574A (en) | 1994-05-23 | 1995-11-21 | Dais Corporation | Fuel cell incorporating novel ion-conducting membrane |
US6185457B1 (en) | 1994-05-31 | 2001-02-06 | Galvani, Ltd. | Method and apparatus for electrically forcing cardiac output in an arrhythmia patient |
US5629077A (en) | 1994-06-27 | 1997-05-13 | Advanced Cardiovascular Systems, Inc. | Biodegradable mesh and film stent |
US5788979A (en) | 1994-07-22 | 1998-08-04 | Inflow Dynamics Inc. | Biodegradable coating with inhibitory properties for application to biocompatible materials |
US5891108A (en) | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
US5649977A (en) | 1994-09-22 | 1997-07-22 | Advanced Cardiovascular Systems, Inc. | Metal reinforced polymer stent |
JPH0889518A (ja) * | 1994-09-25 | 1996-04-09 | Terumo Corp | 中空器官接続用器具 |
US5773925A (en) | 1994-10-24 | 1998-06-30 | Sony Corporation | Electron gun for a cathode ray tube |
US5836964A (en) | 1996-10-30 | 1998-11-17 | Medinol Ltd. | Stent fabrication method |
DE4440386A1 (de) | 1994-11-11 | 1996-05-15 | Pacesetter Ab | Elektroden für medizinische Anwendungen |
CA2163824C (en) | 1994-11-28 | 2000-06-20 | Richard J. Saunders | Method and apparatus for direct laser cutting of metal stents |
US5637113A (en) | 1994-12-13 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | Polymer film for wrapping a stent structure |
US5755722A (en) | 1994-12-22 | 1998-05-26 | Boston Scientific Corporation | Stent placement device with medication dispenser and method |
US6017577A (en) | 1995-02-01 | 2000-01-25 | Schneider (Usa) Inc. | Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices |
US6981986B1 (en) * | 1995-03-01 | 2006-01-03 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US7204848B1 (en) | 1995-03-01 | 2007-04-17 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US6124523A (en) | 1995-03-10 | 2000-09-26 | Impra, Inc. | Encapsulated stent |
US6306144B1 (en) | 1996-11-01 | 2001-10-23 | Scimed Life Systems, Inc. | Selective coating of a balloon catheter with lubricious material for stent deployment |
US5605696A (en) | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
US5848351A (en) | 1995-04-03 | 1998-12-08 | Mitsubishi Materials Corporation | Porous metallic material having high specific surface area, method of producing the same, porous metallic plate material and electrode for alkaline secondary battery |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
DE29624503U1 (de) | 1995-04-19 | 2004-09-16 | Boston Scientific Scimed, Inc. | Arzneimittel-freisetzender beschichteter Stent |
US6132463A (en) | 1995-05-19 | 2000-10-17 | Etex Corporation | Cell seeding of ceramic compositions |
US6027742A (en) | 1995-05-19 | 2000-02-22 | Etex Corporation | Bioresorbable ceramic composites |
WO1996037165A1 (en) | 1995-05-26 | 1996-11-28 | Bsi Corporation | Method and implantable article for promoting endothelialization |
US5674242A (en) | 1995-06-06 | 1997-10-07 | Quanam Medical Corporation | Endoprosthetic device with therapeutic compound |
US7550005B2 (en) | 1995-06-07 | 2009-06-23 | Cook Incorporated | Coated implantable medical device |
US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
AU716005B2 (en) | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
US5676685A (en) | 1995-06-22 | 1997-10-14 | Razavi; Ali | Temporary stent |
US5840387A (en) | 1995-07-28 | 1998-11-24 | Aegis Biosciences L.L.C. | Sulfonated multiblock copolymer and uses therefor |
NZ315995A (en) | 1995-09-01 | 1999-09-29 | Millenium Biologix Inc | Artificial sintered composition comprising stabilised calcium phosphate phases capable of supporting bone cell activity |
EP0765660A3 (en) | 1995-09-28 | 1998-09-23 | Takeda Chemical Industries, Ltd. | Microcapsules comprising 2-piperazinone-1-acetic acid compounds |
EP0957979B1 (en) | 1995-09-29 | 2007-05-23 | Vyteris, Inc. | Low-cost electrodes for an iontophoretic device |
WO1997011746A1 (en) | 1995-09-29 | 1997-04-03 | Medtronic, Inc. | Adaptive search av and auto pvarp adaptation to same with additional benefit |
US5758562A (en) | 1995-10-11 | 1998-06-02 | Schneider (Usa) Inc. | Process for manufacturing braided composite prosthesis |
DE19539449A1 (de) | 1995-10-24 | 1997-04-30 | Biotronik Mess & Therapieg | Verfahren zur Herstellung intraluminaler Stents aus bioresorbierbarem Polymermaterial |
US5603556A (en) | 1995-11-20 | 1997-02-18 | Technical Services And Marketing, Inc. | Rail car load sensor |
US5788626A (en) * | 1995-11-21 | 1998-08-04 | Schneider (Usa) Inc | Method of making a stent-graft covered with expanded polytetrafluoroethylene |
DE19544750A1 (de) | 1995-11-30 | 1997-06-05 | Christoph Rehberg | Implantierbare Vorrichtung mit Innenelektrode zur Förderung des Gewebewachstums |
US5658327A (en) | 1995-12-19 | 1997-08-19 | Ventritex, Inc. | Intracardiac lead having a compliant fixation device |
US5800512A (en) | 1996-01-22 | 1998-09-01 | Meadox Medicals, Inc. | PTFE vascular graft |
JP2001502605A (ja) | 1996-01-30 | 2001-02-27 | メドトロニック,インコーポレーテッド | ステントを作るための物品および方法 |
US6051017A (en) | 1996-02-20 | 2000-04-18 | Advanced Bionics Corporation | Implantable microstimulator and systems employing the same |
US5951458A (en) | 1996-02-29 | 1999-09-14 | Scimed Life Systems, Inc. | Local application of oxidizing agents to prevent restenosis |
US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
CA2199890C (en) | 1996-03-26 | 2002-02-05 | Leonard Pinchuk | Stents and stent-grafts having enhanced hoop strength and methods of making the same |
US5880661A (en) | 1996-04-01 | 1999-03-09 | Emf Therapeutics, Inc. | Complex magnetic field generating device |
US5976454A (en) | 1996-04-01 | 1999-11-02 | Basf Aktiengesellschaft | Process for producing open-celled, inorganic sintered foam products |
US20040106985A1 (en) | 1996-04-26 | 2004-06-03 | Jang G. David | Intravascular stent |
US6783543B2 (en) | 2000-06-05 | 2004-08-31 | Scimed Life Systems, Inc. | Intravascular stent with increasing coating retaining capacity |
US5922021A (en) | 1996-04-26 | 1999-07-13 | Jang; G. David | Intravascular stent |
US5891191A (en) | 1996-04-30 | 1999-04-06 | Schneider (Usa) Inc | Cobalt-chromium-molybdenum alloy stent and stent-graft |
US6592617B2 (en) | 1996-04-30 | 2003-07-15 | Boston Scientific Scimed, Inc. | Three-dimensional braided covered stent |
US5951881A (en) | 1996-07-22 | 1999-09-14 | President And Fellows Of Harvard College | Fabrication of small-scale cylindrical articles |
US5693928A (en) | 1996-06-27 | 1997-12-02 | International Business Machines Corporation | Method for producing a diffusion barrier and polymeric article having a diffusion barrier |
US5769884A (en) | 1996-06-27 | 1998-06-23 | Cordis Corporation | Controlled porosity endovascular implant |
US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
US6253252B1 (en) | 1996-07-11 | 2001-06-26 | Andrew Schofield | Method and apparatus for asynchronously calling and implementing objects |
US5941843A (en) | 1996-07-12 | 1999-08-24 | Empi, Inc. | Iontophoresis electrode |
US6120535A (en) | 1996-07-29 | 2000-09-19 | Radiance Medical Systems, Inc. | Microporous tubular prosthesis |
US5741331A (en) | 1996-07-29 | 1998-04-21 | Corvita Corporation | Biostable elastomeric polymers having quaternary carbons |
US5830217A (en) | 1996-08-09 | 1998-11-03 | Thomas J. Fogarty | Soluble fixation device and method for stent delivery catheters |
US6174329B1 (en) | 1996-08-22 | 2001-01-16 | Advanced Cardiovascular Systems, Inc. | Protective coating for a stent with intermediate radiopaque coating |
US6756060B1 (en) | 1996-09-19 | 2004-06-29 | Usbiomaterials Corp. | Anti-inflammatory and antimicrobial uses for bioactive glass compositions |
US6953594B2 (en) | 1996-10-10 | 2005-10-11 | Etex Corporation | Method of preparing a poorly crystalline calcium phosphate and methods of its use |
AU734691B2 (en) | 1996-10-16 | 2001-06-21 | Life Science Enterprises, Inc. | Bioceramic compositions |
US5761775A (en) | 1996-10-17 | 1998-06-09 | Legome; Mark J. | Mushroom and loop material closure system for high shear strength and low peel strength applications |
US6387121B1 (en) | 1996-10-21 | 2002-05-14 | Inflow Dynamics Inc. | Vascular and endoluminal stents with improved coatings |
US5824045A (en) | 1996-10-21 | 1998-10-20 | Inflow Dynamics Inc. | Vascular and endoluminal stents |
US6099561A (en) | 1996-10-21 | 2000-08-08 | Inflow Dynamics, Inc. | Vascular and endoluminal stents with improved coatings |
US6000601A (en) * | 1996-10-22 | 1999-12-14 | Boston Scientific Corporation | Welding method |
US5852277A (en) | 1996-10-24 | 1998-12-22 | Spectralytics, Inc. | Laser cutting tool for cutting elongated hollow workpieces |
US6530951B1 (en) | 1996-10-24 | 2003-03-11 | Cook Incorporated | Silver implantable medical device |
US5869141A (en) | 1996-11-04 | 1999-02-09 | The Boeing Company | Surface pretreatment for sol coating of metals |
US6106473A (en) | 1996-11-06 | 2000-08-22 | Sts Biopolymers, Inc. | Echogenic coatings |
JP2001504017A (ja) | 1996-11-15 | 2001-03-27 | クック インコーポレーティッド. | 分離可能なスリーブ,ステント配備装置 |
US6114099A (en) | 1996-11-21 | 2000-09-05 | Virginia Tech Intellectual Properties, Inc. | Patterned molecular self-assembly |
ZA9710342B (en) | 1996-11-25 | 1998-06-10 | Alza Corp | Directional drug delivery stent and method of use. |
US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
US6021347A (en) | 1996-12-05 | 2000-02-01 | Herbst; Ewa | Electrochemical treatment of malignant tumors |
US6251980B1 (en) | 1996-12-06 | 2001-06-26 | Amcol International Corporation | Nanocomposites formed by onium ion-intercalated clay and rigid anhydride-cured epoxy resins |
US5871437A (en) | 1996-12-10 | 1999-02-16 | Inflow Dynamics, Inc. | Radioactive stent for treating blood vessels to prevent restenosis |
US5906759A (en) | 1996-12-26 | 1999-05-25 | Medinol Ltd. | Stent forming apparatus with stent deforming blades |
IT1289815B1 (it) | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | Stent per angioplastica e relativo procedimento di produzione |
US6013591A (en) * | 1997-01-16 | 2000-01-11 | Massachusetts Institute Of Technology | Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production |
US5858556A (en) | 1997-01-21 | 1999-01-12 | Uti Corporation | Multilayer composite tubular structure and method of making |
US8663311B2 (en) | 1997-01-24 | 2014-03-04 | Celonova Stent, Inc. | Device comprising biodegradable bistable or multistable cells and methods of use |
CA2278640C (en) | 1997-01-24 | 2007-12-11 | Petrus Antonius Besselink | Bistable spring construction for a stent and other medical apparatus |
EP1007139A4 (en) | 1997-02-12 | 2000-06-14 | Prolifix Medical Inc | ENDOVASCULAR PROSTHESIS EXTRACTION APPARATUS |
US6164284A (en) | 1997-02-26 | 2000-12-26 | Schulman; Joseph H. | System of implantable devices for monitoring and/or affecting body parameters |
WO1998038947A1 (en) | 1997-03-05 | 1998-09-11 | Scimed Life Systems, Inc. | Conformal laminate stent device |
US20020133222A1 (en) | 1997-03-05 | 2002-09-19 | Das Gladwin S. | Expandable stent having a plurality of interconnected expansion modules |
US5830229A (en) * | 1997-03-07 | 1998-11-03 | Micro Therapeutics Inc. | Hoop stent |
US5815904A (en) | 1997-03-13 | 1998-10-06 | Intratherapeutics, Inc. | Method for making a stent |
US5977204A (en) | 1997-04-11 | 1999-11-02 | Osteobiologics, Inc. | Biodegradable implant material comprising bioactive ceramic |
US8172897B2 (en) | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US5843172A (en) | 1997-04-15 | 1998-12-01 | Advanced Cardiovascular Systems, Inc. | Porous medicated stent |
US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
IT1292295B1 (it) | 1997-04-29 | 1999-01-29 | Sorin Biomedica Cardio Spa | Stent per angioplastica |
US5879697A (en) | 1997-04-30 | 1999-03-09 | Schneider Usa Inc | Drug-releasing coatings for medical devices |
DE19724223C1 (de) | 1997-04-30 | 1998-12-24 | Schering Ag | Verfahren zur Herstellung elektrochemisch beschichteter radioaktiver Stents und ihre Verwendung zur Restenoseprophylaxe |
US5980554A (en) | 1997-05-05 | 1999-11-09 | Micro Therapeutics, Inc. | Wire frame partial flow obstruction for aneurysm treatment |
CA2308396A1 (en) | 1997-05-14 | 1998-11-19 | Novo Rps Ulc | Expandable stent and method for production of same |
US6025036A (en) | 1997-05-28 | 2000-02-15 | The United States Of America As Represented By The Secretary Of The Navy | Method of producing a film coating by matrix assisted pulsed laser deposition |
GB2325934A (en) | 1997-06-03 | 1998-12-09 | Polybiomed Ltd | Treating metal surfaces to enhance bio-compatibility and/or physical characteristics |
US6203536B1 (en) | 1997-06-17 | 2001-03-20 | Medtronic, Inc. | Medical device for delivering a therapeutic substance and method therefor |
US5749809A (en) | 1997-06-20 | 1998-05-12 | Lin; Ting Fung | Stepping and swinging exerciser |
US6500174B1 (en) | 1997-07-08 | 2002-12-31 | Atrionix, Inc. | Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member |
US20020169493A1 (en) | 1997-07-10 | 2002-11-14 | Widenhouse Christopher W. | Anti-thrombogenic coatings for biomedical devices |
US5817046A (en) | 1997-07-14 | 1998-10-06 | Delcath Systems, Inc. | Apparatus and method for isolated pelvic perfusion |
FR2766092B1 (fr) | 1997-07-16 | 1999-10-08 | Centre Nat Rech Scient | Dispositif implantable recouvert d'un polymere capable de liberer des substances biologiquement actives |
DE19731021A1 (de) | 1997-07-18 | 1999-01-21 | Meyer Joerg | In vivo abbaubares metallisches Implantat |
US5972192A (en) | 1997-07-23 | 1999-10-26 | Advanced Micro Devices, Inc. | Pulse electroplating copper or copper alloys |
US6174330B1 (en) | 1997-08-01 | 2001-01-16 | Schneider (Usa) Inc | Bioabsorbable marker having radiopaque constituents |
US6245103B1 (en) | 1997-08-01 | 2001-06-12 | Schneider (Usa) Inc | Bioabsorbable self-expanding stent |
US5980564A (en) | 1997-08-01 | 1999-11-09 | Schneider (Usa) Inc. | Bioabsorbable implantable endoprosthesis with reservoir |
US5899935A (en) | 1997-08-04 | 1999-05-04 | Schneider (Usa) Inc. | Balloon expandable braided stent with restraint |
DE19734972A1 (de) | 1997-08-13 | 1999-02-18 | Cerdec Ag | Goldhaltige nanoporöse Aluminiumoxid-Membranen, Verfahren zu deren Herstellung und deren Verwendung |
US5854382A (en) | 1997-08-18 | 1998-12-29 | Meadox Medicals, Inc. | Bioresorbable compositions for implantable prostheses |
US6316522B1 (en) * | 1997-08-18 | 2001-11-13 | Scimed Life Systems, Inc. | Bioresorbable hydrogel compositions for implantable prostheses |
US6143370A (en) | 1997-08-27 | 2000-11-07 | Northeastern University | Process for producing polymer coatings with various porosities and surface areas |
US6884429B2 (en) * | 1997-09-05 | 2005-04-26 | Isotechnika International Inc. | Medical devices incorporating deuterated rapamycin for controlled delivery thereof |
US6342507B1 (en) | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
US5972027A (en) | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
DE19746735C2 (de) * | 1997-10-13 | 2003-11-06 | Simag Gmbh Systeme Und Instr F | NMR-Bildgebungsverfahren zur Darstellung, Positionsbestimmung oder funktionellen Kontrolle einer in ein Untersuchungsobjekt eingeführten Vorrichtung und Vorrichtung zur Verwendung in einem derartigen Verfahren |
CA2218983C (en) | 1997-10-21 | 2001-05-08 | Mag R&D, Inc. | Cathodic protective coating on magnesium or its alloys and method of producing the same |
US6273908B1 (en) | 1997-10-24 | 2001-08-14 | Robert Ndondo-Lay | Stents |
US6309414B1 (en) | 1997-11-04 | 2001-10-30 | Sorin Biomedica Cardio S.P.A. | Angioplasty stents |
AU749980B2 (en) | 1997-11-07 | 2002-07-04 | Advanced Bio Prosthetic Surfaces, Ltd. | Metallic Intravascular Stent and Method of Manufacturing a Metallic Intravascular Stent |
ATE307110T1 (de) | 1997-11-07 | 2005-11-15 | Univ Rutgers | Strahlungsdurchlässiges polymeres biomaterial |
NO311781B1 (no) | 1997-11-13 | 2002-01-28 | Medinol Ltd | Flerlags-stenter av metall |
US5957975A (en) | 1997-12-15 | 1999-09-28 | The Cleveland Clinic Foundation | Stent having a programmed pattern of in vivo degradation |
US5976169A (en) | 1997-12-16 | 1999-11-02 | Cardiovasc, Inc. | Stent with silver coating and method |
US6212434B1 (en) | 1998-07-22 | 2001-04-03 | Cardiac Pacemakers, Inc. | Single pass lead system |
US6626939B1 (en) | 1997-12-18 | 2003-09-30 | Boston Scientific Scimed, Inc. | Stent-graft with bioabsorbable structural support |
US6140740A (en) | 1997-12-30 | 2000-10-31 | Remon Medical Technologies, Ltd. | Piezoelectric transducer |
US6486588B2 (en) | 1997-12-30 | 2002-11-26 | Remon Medical Technologies Ltd | Acoustic biosensor for monitoring physiological conditions in a body implantation site |
US6451871B1 (en) | 1998-11-25 | 2002-09-17 | Novartis Ag | Methods of modifying surface characteristics |
US6120660A (en) | 1998-02-11 | 2000-09-19 | Silicon Genesis Corporation | Removable liner design for plasma immersion ion implantation |
PL342996A1 (en) | 1998-02-23 | 2001-07-16 | Mnemoscience Gmbh | Shape memory polymers |
US6730117B1 (en) * | 1998-03-05 | 2004-05-04 | Scimed Life Systems, Inc. | Intraluminal stent |
US6139585A (en) | 1998-03-11 | 2000-10-31 | Depuy Orthopaedics, Inc. | Bioactive ceramic coating and method |
DE19811033C1 (de) | 1998-03-13 | 1999-08-05 | Aesculap Ag & Co Kg | Chirurgisches Instrument und Verfahren zu dessen Herstellung |
EP1064088B1 (en) | 1998-03-19 | 2002-12-04 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates |
EP0972563A1 (en) | 1998-07-15 | 2000-01-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates |
US7547445B2 (en) | 1998-03-19 | 2009-06-16 | Surmodics, Inc. | Crosslinkable macromers |
US7208011B2 (en) | 2001-08-20 | 2007-04-24 | Conor Medsystems, Inc. | Implantable medical device with drug filled holes |
US20040254635A1 (en) | 1998-03-30 | 2004-12-16 | Shanley John F. | Expandable medical device for delivery of beneficial agent |
US6241762B1 (en) | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US5980566A (en) | 1998-04-11 | 1999-11-09 | Alt; Eckhard | Vascular and endoluminal stents with iridium oxide coating |
US7713297B2 (en) * | 1998-04-11 | 2010-05-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US6364856B1 (en) | 1998-04-14 | 2002-04-02 | Boston Scientific Corporation | Medical device with sponge coating for controlled drug release |
US6206916B1 (en) | 1998-04-15 | 2001-03-27 | Joseph G. Furst | Coated intraluminal graft |
US20020099438A1 (en) | 1998-04-15 | 2002-07-25 | Furst Joseph G. | Irradiated stent coating |
US6436133B1 (en) | 1998-04-15 | 2002-08-20 | Joseph G. Furst | Expandable graft |
US6264687B1 (en) | 1998-04-20 | 2001-07-24 | Cordis Corporation | Multi-laminate stent having superelastic articulated sections |
US6270831B2 (en) | 1998-04-30 | 2001-08-07 | Medquest Products, Inc. | Method and apparatus for providing a conductive, amorphous non-stick coating |
US6206914B1 (en) | 1998-04-30 | 2001-03-27 | Medtronic, Inc. | Implantable system with drug-eluting cells for on-demand local drug delivery |
JP4583597B2 (ja) | 1998-05-05 | 2010-11-17 | ボストン サイエンティフィック リミテッド | 末端が滑らかなステント |
US6206283B1 (en) | 1998-12-23 | 2001-03-27 | At&T Corp. | Method and apparatus for transferring money via a telephone call |
US6280411B1 (en) | 1998-05-18 | 2001-08-28 | Scimed Life Systems, Inc. | Localized delivery of drug agents |
US8177743B2 (en) | 1998-05-18 | 2012-05-15 | Boston Scientific Scimed, Inc. | Localized delivery of drug agents |
US6086773A (en) | 1998-05-22 | 2000-07-11 | Bmc Industries, Inc. | Method and apparatus for etching-manufacture of cylindrical elements |
ATE206936T1 (de) | 1998-06-25 | 2001-11-15 | Vascular Biotech Gmbh | Autologe epithelialisierung bzw. endothelialisierung von hohlorganen bzw. gefässen |
DE19856983A1 (de) | 1998-06-25 | 1999-12-30 | Biotronik Mess & Therapieg | Implantierbare, bioresorbierbare Gefäßwandstütze, insbesondere Koronarstent |
DE59913189D1 (de) | 1998-06-25 | 2006-05-04 | Biotronik Ag | Implantierbare, bioresorbierbare Gefässwandstütze, insbesondere Koronarstent |
US6153252A (en) | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
US6652581B1 (en) | 1998-07-07 | 2003-11-25 | Boston Scientific Scimed, Inc. | Medical device with porous surface for controlled drug release and method of making the same |
US6261319B1 (en) | 1998-07-08 | 2001-07-17 | Scimed Life Systems, Inc. | Stent |
US6096175A (en) | 1998-07-17 | 2000-08-01 | Micro Therapeutics, Inc. | Thin film stent |
US7967855B2 (en) | 1998-07-27 | 2011-06-28 | Icon Interventional Systems, Inc. | Coated medical device |
US8070796B2 (en) | 1998-07-27 | 2011-12-06 | Icon Interventional Systems, Inc. | Thrombosis inhibiting graft |
US20020038146A1 (en) | 1998-07-29 | 2002-03-28 | Ulf Harry | Expandable stent with relief cuts for carrying medicines and other materials |
US20040088041A1 (en) | 1999-07-20 | 2004-05-06 | Stanford Ulf Harry | Expandable stent with array of relief cuts |
US20010032011A1 (en) | 1999-07-20 | 2001-10-18 | Stanford Ulf Harry | Expandable stent with array of relief cuts |
JP4898991B2 (ja) | 1998-08-20 | 2012-03-21 | クック メディカル テクノロジーズ エルエルシー | 被覆付植込式医療装置 |
US7235096B1 (en) | 1998-08-25 | 2007-06-26 | Tricardia, Llc | Implantable device for promoting repair of a body lumen |
US6335029B1 (en) | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
US6755856B2 (en) | 1998-09-05 | 2004-06-29 | Abbott Laboratories Vascular Enterprises Limited | Methods and apparatus for stenting comprising enhanced embolic protection, coupled with improved protection against restenosis and thrombus formation |
US6206915B1 (en) | 1998-09-29 | 2001-03-27 | Medtronic Ave, Inc. | Drug storing and metering stent |
US6358276B1 (en) | 1998-09-30 | 2002-03-19 | Impra, Inc. | Fluid containing endoluminal stent |
US6217607B1 (en) | 1998-10-20 | 2001-04-17 | Inflow Dynamics Inc. | Premounted stent delivery system for small vessels |
US6245104B1 (en) | 1999-02-28 | 2001-06-12 | Inflow Dynamics Inc. | Method of fabricating a biocompatible stent |
US6042597A (en) | 1998-10-23 | 2000-03-28 | Scimed Life Systems, Inc. | Helical stent design |
DE19855421C2 (de) | 1998-11-02 | 2001-09-20 | Alcove Surfaces Gmbh | Implantat |
US6348960B1 (en) | 1998-11-06 | 2002-02-19 | Kimotot Co., Ltd. | Front scattering film |
US6214042B1 (en) | 1998-11-10 | 2001-04-10 | Precision Vascular Systems, Inc. | Micro-machined stent for vessels, body ducts and the like |
US6477268B1 (en) | 1998-11-17 | 2002-11-05 | Industrial Technology Research Institute | Producing transitions between vistas |
US6984404B1 (en) | 1998-11-18 | 2006-01-10 | University Of Florida Research Foundation, Inc. | Methods for preparing coated drug particles and pharmaceutical formulations thereof |
US6263249B1 (en) * | 1999-02-26 | 2001-07-17 | Medtronic, Inc. | Medical electrical lead having controlled texture surface and method of making same |
US6063101A (en) | 1998-11-20 | 2000-05-16 | Precision Vascular Systems, Inc. | Stent apparatus and method |
DE59904296D1 (de) | 1998-11-26 | 2003-03-20 | Siemens Ag | Komplexverbindung eines elements der iv nebengruppe |
US20060178727A1 (en) | 1998-12-03 | 2006-08-10 | Jacob Richter | Hybrid amorphous metal alloy stent |
SE9804536D0 (sv) | 1998-12-23 | 1998-12-23 | A & Science Invest Ab | Biological implant and method for production thereof |
US6517571B1 (en) | 1999-01-22 | 2003-02-11 | Gore Enterprise Holdings, Inc. | Vascular graft with improved flow surfaces |
US6955661B1 (en) | 1999-01-25 | 2005-10-18 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
US6419692B1 (en) | 1999-02-03 | 2002-07-16 | Scimed Life Systems, Inc. | Surface protection method for stents and balloon catheters for drug delivery |
US6264595B1 (en) | 1999-02-04 | 2001-07-24 | Mobeta, Inc. | Radioactive transition metal stents |
RU2218242C2 (ru) | 1999-02-11 | 2003-12-10 | Физический институт им. П.Н. Лебедева РАН | Способ изготовления медицинских имплантатов из биосовместимых материалов |
US6231597B1 (en) * | 1999-02-16 | 2001-05-15 | Mark E. Deem | Apparatus and methods for selectively stenting a portion of a vessel wall |
WO2000048530A1 (en) | 1999-02-16 | 2000-08-24 | Talison Research, Inc. | Multilayer and multifunction vascular graft |
DE19948783C2 (de) | 1999-02-18 | 2001-06-13 | Alcove Surfaces Gmbh | Implantat |
US6162238A (en) | 1999-02-24 | 2000-12-19 | Aaron V. Kaplan | Apparatus and methods for control of body lumens |
US6296604B1 (en) | 1999-03-17 | 2001-10-02 | Stereotaxis, Inc. | Methods of and compositions for treating vascular defects |
US6214037B1 (en) | 1999-03-18 | 2001-04-10 | Fossa Industries, Llc | Radially expanding stent |
US6364903B2 (en) | 1999-03-19 | 2002-04-02 | Meadox Medicals, Inc. | Polymer coated stent |
US6170488B1 (en) | 1999-03-24 | 2001-01-09 | The B. F. Goodrich Company | Acoustic-based remotely interrogated diagnostic implant device and system |
US6558422B1 (en) | 1999-03-26 | 2003-05-06 | University Of Washington | Structures having coated indentations |
US6312457B1 (en) | 1999-04-01 | 2001-11-06 | Boston Scientific Corporation | Intraluminal lining |
US6425855B2 (en) | 1999-04-06 | 2002-07-30 | Cordis Corporation | Method for making a multi-laminate stent having superelastic articulated sections |
US6325825B1 (en) | 1999-04-08 | 2001-12-04 | Cordis Corporation | Stent with variable wall thickness |
US6366808B1 (en) | 2000-03-13 | 2002-04-02 | Edward A. Schroeppel | Implantable device and method for the electrical treatment of cancer |
US6258117B1 (en) | 1999-04-15 | 2001-07-10 | Mayo Foundation For Medical Education And Research | Multi-section stent |
US6368658B1 (en) | 1999-04-19 | 2002-04-09 | Scimed Life Systems, Inc. | Coating medical devices using air suspension |
US6607598B2 (en) | 1999-04-19 | 2003-08-19 | Scimed Life Systems, Inc. | Device for protecting medical devices during a coating process |
US6192271B1 (en) | 1999-04-20 | 2001-02-20 | Michael Hayman | Radiotherapy stent |
US6287335B1 (en) | 1999-04-26 | 2001-09-11 | William J. Drasler | Intravascular folded tubular endoprosthesis |
US7371400B2 (en) | 2001-01-02 | 2008-05-13 | The General Hospital Corporation | Multilayer device for tissue engineering |
US6461731B1 (en) | 1999-05-03 | 2002-10-08 | Guardian Industries Corp. | Solar management coating system including protective DLC |
US6201991B1 (en) | 1999-05-07 | 2001-03-13 | Heart Care Associates, Llc | Method of prevention and treatment of atherosclerosis and article of manufacture therefor |
US6726712B1 (en) * | 1999-05-14 | 2004-04-27 | Boston Scientific Scimed | Prosthesis deployment device with translucent distal end |
US6610035B2 (en) | 1999-05-21 | 2003-08-26 | Scimed Life Systems, Inc. | Hydrophilic lubricity coating for medical devices comprising a hybrid top coat |
US6689160B1 (en) * | 1999-05-31 | 2004-02-10 | Sumitomo Electric Industries, Ltd. | Prosthesis for blood vessel |
US6368346B1 (en) | 1999-06-03 | 2002-04-09 | American Medical Systems, Inc. | Bioresorbable stent |
US6406745B1 (en) | 1999-06-07 | 2002-06-18 | Nanosphere, Inc. | Methods for coating particles and particles produced thereby |
US7306625B1 (en) * | 1999-06-24 | 2007-12-11 | Abbott Laboratories | Balloon expandable stent |
US6139913A (en) | 1999-06-29 | 2000-10-31 | National Center For Manufacturing Sciences | Kinetic spray coating method and apparatus |
US6409754B1 (en) | 1999-07-02 | 2002-06-25 | Scimed Life Systems, Inc. | Flexible segmented stent |
US6258121B1 (en) | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
NO312106B1 (no) | 1999-07-02 | 2002-03-18 | Norsk Hydro As | Fremgangsmåte for å forbedre korrosjonsmotstanden for magnesium-aluminium-silisiumlegeringer og magnesiumlegering medforbedret korrosjonsmotstand |
IT1307263B1 (it) | 1999-08-05 | 2001-10-30 | Sorin Biomedica Cardio Spa | Stent per angioplastica con azione antagonista della restenosi,relativo corredo e componenti. |
US20040073155A1 (en) | 2000-01-14 | 2004-04-15 | Broncus Technologies, Inc. | Methods and devices for maintaining patency of surgically created channels in tissue |
US6458162B1 (en) | 1999-08-13 | 2002-10-01 | Vita Special Purpose Corporation | Composite shaped bodies and methods for their production and use |
US6869701B1 (en) | 1999-08-16 | 2005-03-22 | Carolyn Aita | Self-repairing ceramic coatings |
US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6287628B1 (en) | 1999-09-03 | 2001-09-11 | Advanced Cardiovascular Systems, Inc. | Porous prosthesis and a method of depositing substances into the pores |
US6503556B2 (en) | 2000-12-28 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Methods of forming a coating for a prosthesis |
DE19950386A1 (de) | 1999-10-19 | 2001-05-10 | Miladin Lazarov | Biokompatibler Gegenstand |
DE19951477A1 (de) | 1999-10-26 | 2001-05-03 | Biotronik Mess & Therapieg | Stent |
US8808272B2 (en) | 1999-10-28 | 2014-08-19 | Boston Scientific Scimed, Inc. | Biocompatible medical devices |
US6521284B1 (en) | 1999-11-03 | 2003-02-18 | Scimed Life Systems, Inc. | Process for impregnating a porous material with a cross-linkable composition |
US6733513B2 (en) | 1999-11-04 | 2004-05-11 | Advanced Bioprosthetic Surfaces, Ltd. | Balloon catheter having metal balloon and method of making same |
US7226475B2 (en) | 1999-11-09 | 2007-06-05 | Boston Scientific Scimed, Inc. | Stent with variable properties |
US6337076B1 (en) | 1999-11-17 | 2002-01-08 | Sg Licensing Corporation | Method and composition for the treatment of scars |
US6491666B1 (en) | 1999-11-17 | 2002-12-10 | Microchips, Inc. | Microfabricated devices for the delivery of molecules into a carrier fluid |
US6936066B2 (en) | 1999-11-19 | 2005-08-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Complaint implantable medical devices and methods of making same |
US7300457B2 (en) | 1999-11-19 | 2007-11-27 | Advanced Bio Prosthetic Surfaces, Ltd. | Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same |
US7235092B2 (en) | 1999-11-19 | 2007-06-26 | Advanced Bio Prosthetic Surfaces, Ltd. | Guidewires and thin film catheter-sheaths and method of making same |
US6849085B2 (en) | 1999-11-19 | 2005-02-01 | Advanced Bio Prosthetic Surfaces, Ltd. | Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same |
US7335426B2 (en) | 1999-11-19 | 2008-02-26 | Advanced Bio Prosthetic Surfaces, Ltd. | High strength vacuum deposited nitinol alloy films and method of making same |
US6379383B1 (en) | 1999-11-19 | 2002-04-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal device exhibiting improved endothelialization and method of manufacture thereof |
US6537310B1 (en) | 1999-11-19 | 2003-03-25 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal implantable devices and method of making same |
US7195641B2 (en) | 1999-11-19 | 2007-03-27 | Advanced Bio Prosthetic Surfaces, Ltd. | Valvular prostheses having metal or pseudometallic construction and methods of manufacture |
US6277078B1 (en) | 1999-11-19 | 2001-08-21 | Remon Medical Technologies, Ltd. | System and method for monitoring a parameter associated with the performance of a heart |
US6458153B1 (en) | 1999-12-31 | 2002-10-01 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
US20060013850A1 (en) | 1999-12-03 | 2006-01-19 | Domb Abraham J | Electropolymerizable monomers and polymeric coatings on implantable devices prepared therefrom |
EP1233795B1 (en) | 1999-12-03 | 2006-02-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Electropolymerizable monomers and polymeric coatings on implantable devices |
US6251136B1 (en) | 1999-12-08 | 2001-06-26 | Advanced Cardiovascular Systems, Inc. | Method of layering a three-coated stent using pharmacological and polymeric agents |
US6602287B1 (en) | 1999-12-08 | 2003-08-05 | Advanced Cardiovascular Systems, Inc. | Stent with anti-thrombogenic coating |
US6554854B1 (en) | 1999-12-10 | 2003-04-29 | Scimed Life Systems, Inc. | Process for laser joining dissimilar metals and endoluminal stent with radiopaque marker produced thereby |
US6338739B1 (en) * | 1999-12-22 | 2002-01-15 | Ethicon, Inc. | Biodegradable stent |
US6613432B2 (en) | 1999-12-22 | 2003-09-02 | Biosurface Engineering Technologies, Inc. | Plasma-deposited coatings, devices and methods |
US6908624B2 (en) | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6471721B1 (en) | 1999-12-30 | 2002-10-29 | Advanced Cardiovascular Systems, Inc. | Vascular stent having increased radiopacity and method for making same |
US6899731B2 (en) | 1999-12-30 | 2005-05-31 | Boston Scientific Scimed, Inc. | Controlled delivery of therapeutic agents by insertable medical devices |
US6451177B1 (en) | 2000-01-21 | 2002-09-17 | Applied Materials, Inc. | Vault shaped target and magnetron operable in two sputtering modes |
US6533905B2 (en) * | 2000-01-24 | 2003-03-18 | Tini Alloy Company | Method for sputtering tini shape-memory alloys |
CA2393330A1 (en) | 2000-01-25 | 2001-08-02 | Boston Scientific Limited | Manufacturing medical devices by vapor deposition |
US6312463B1 (en) | 2000-02-01 | 2001-11-06 | Endotex Interventional Systems, Inc. | Micro-porous mesh stent with hybrid structure |
US6375826B1 (en) | 2000-02-14 | 2002-04-23 | Advanced Cardiovascular Systems, Inc. | Electro-polishing fixture and electrolyte solution for polishing stents and method |
AU780539B2 (en) | 2000-02-25 | 2005-03-24 | Cordis Corporation | Use of cladribine on a stent to prevent restenosis |
US6440503B1 (en) | 2000-02-25 | 2002-08-27 | Scimed Life Systems, Inc. | Laser deposition of elements onto medical devices |
EP1132058A1 (en) | 2000-03-06 | 2001-09-12 | Advanced Laser Applications Holding S.A. | Intravascular prothesis |
US6379382B1 (en) | 2000-03-13 | 2002-04-30 | Jun Yang | Stent having cover with drug delivery capability |
US6290722B1 (en) | 2000-03-13 | 2001-09-18 | Endovascular Technologies, Inc. | Tacky attachment method of covered materials on stents |
US20160287708A9 (en) | 2000-03-15 | 2016-10-06 | Orbusneich Medical, Inc. | Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device |
EP1263484B1 (en) | 2000-03-15 | 2007-05-16 | OrbusNeich Medical, Inc. | Coating which promotes endothelial cell adherence |
US6695865B2 (en) | 2000-03-20 | 2004-02-24 | Advanced Bio Prosthetic Surfaces, Ltd. | Embolic protection device |
US6315708B1 (en) | 2000-03-31 | 2001-11-13 | Cordis Corporation | Stent with self-expanding end sections |
US6527801B1 (en) | 2000-04-13 | 2003-03-04 | Advanced Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
US6719987B2 (en) * | 2000-04-17 | 2004-04-13 | Nucryst Pharmaceuticals Corp. | Antimicrobial bioabsorbable materials |
US6327504B1 (en) | 2000-05-10 | 2001-12-04 | Thoratec Corporation | Transcutaneous energy transfer with circuitry arranged to avoid overheating |
US8845713B2 (en) | 2000-05-12 | 2014-09-30 | Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. | Self-supporting laminated films, structural materials and medical devices manufactured therefrom and methods of making same |
KR100360364B1 (ko) | 2000-05-22 | 2002-11-13 | 주식회사 정성메디칼 | 관상동맥 설치용 금속 스텐트 |
US6395326B1 (en) | 2000-05-31 | 2002-05-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for depositing a coating onto a surface of a prosthesis |
US6673385B1 (en) | 2000-05-31 | 2004-01-06 | Advanced Cardiovascular Systems, Inc. | Methods for polymeric coatings stents |
US20040211362A1 (en) | 2000-05-31 | 2004-10-28 | Daniel Castro | System for coating a stent |
JP4545888B2 (ja) | 2000-06-08 | 2010-09-15 | 株式会社泉精器製作所 | 固液分離装置 |
WO2001095834A1 (en) | 2000-06-13 | 2001-12-20 | Scimed Life Systems, Inc. | Disintegrating stent and method of making same |
US6418337B1 (en) | 2000-06-15 | 2002-07-09 | Autolitt Inc. | MRI guided hyperthermia surgery |
JP4656697B2 (ja) | 2000-06-16 | 2011-03-23 | キヤノンアネルバ株式会社 | 高周波スパッタリング装置 |
US6585765B1 (en) | 2000-06-29 | 2003-07-01 | Advanced Cardiovascular Systems, Inc. | Implantable device having substances impregnated therein and a method of impregnating the same |
DE10032220A1 (de) | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung |
US20030018380A1 (en) | 2000-07-07 | 2003-01-23 | Craig Charles H. | Platinum enhanced alloy and intravascular or implantable medical devices manufactured therefrom |
US20030077200A1 (en) | 2000-07-07 | 2003-04-24 | Craig Charles H. | Enhanced radiopaque alloy stent |
US20020144757A1 (en) | 2000-07-07 | 2002-10-10 | Craig Charles Horace | Stainless steel alloy with improved radiopaque characteristics |
AU2001273276A1 (en) | 2000-07-10 | 2002-01-21 | Epion Corporation | Improving effectiveness of medical stents by gcib |
US6709451B1 (en) | 2000-07-14 | 2004-03-23 | Norman Noble, Inc. | Channeled vascular stent apparatus and method |
US6451373B1 (en) | 2000-08-04 | 2002-09-17 | Advanced Cardiovascular Systems, Inc. | Method of forming a therapeutic coating onto a surface of an implantable prosthesis |
US6629992B2 (en) | 2000-08-04 | 2003-10-07 | Advanced Cardiovascular Systems, Inc. | Sheath for self-expanding stent |
WO2002013786A2 (en) | 2000-08-15 | 2002-02-21 | Board Of Trustees Of The University Of Illinois | Method of forming microparticles |
US6390967B1 (en) | 2000-09-14 | 2002-05-21 | Xoft Microtube, Inc. | Radiation for inhibiting hyperplasia after intravascular intervention |
US7101391B2 (en) | 2000-09-18 | 2006-09-05 | Inflow Dynamics Inc. | Primarily niobium stent |
US6478815B1 (en) | 2000-09-18 | 2002-11-12 | Inflow Dynamics Inc. | Vascular and endoluminal stents |
US7402173B2 (en) | 2000-09-18 | 2008-07-22 | Boston Scientific Scimed, Inc. | Metal stent with surface layer of noble metal oxide and method of fabrication |
US6953560B1 (en) * | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
US6716444B1 (en) | 2000-09-28 | 2004-04-06 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
US6254632B1 (en) | 2000-09-28 | 2001-07-03 | Advanced Cardiovascular Systems, Inc. | Implantable medical device having protruding surface structures for drug delivery and cover attachment |
US6805898B1 (en) | 2000-09-28 | 2004-10-19 | Advanced Cardiovascular Systems, Inc. | Surface features of an implantable medical device |
US20020051730A1 (en) | 2000-09-29 | 2002-05-02 | Stanko Bodnar | Coated medical devices and sterilization thereof |
KR200227881Y1 (ko) | 2000-09-29 | 2001-06-15 | 주식회사이오니아테크놀로지 | 치과치료용 영상저장장치 |
US6628989B1 (en) | 2000-10-16 | 2003-09-30 | Remon Medical Technologies, Ltd. | Acoustic switch and apparatus and methods for using acoustic switches within a body |
US6506437B1 (en) * | 2000-10-17 | 2003-01-14 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device having depots formed in a surface thereof |
US6979347B1 (en) | 2000-10-23 | 2005-12-27 | Advanced Cardiovascular Systems, Inc. | Implantable drug delivery prosthesis |
US6663664B1 (en) | 2000-10-26 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent with time variable radial force |
US6558733B1 (en) | 2000-10-26 | 2003-05-06 | Advanced Cardiovascular Systems, Inc. | Method for etching a micropatterned microdepot prosthesis |
US7416559B2 (en) | 2000-10-27 | 2008-08-26 | Poly-Med, Inc. | Micromantled drug-eluting stent |
US6758859B1 (en) | 2000-10-30 | 2004-07-06 | Kenny L. Dang | Increased drug-loading and reduced stress drug delivery device |
JP4583756B2 (ja) | 2000-10-31 | 2010-11-17 | クック インコーポレイテッド | 医療器具 |
US7803149B2 (en) | 2002-07-12 | 2010-09-28 | Cook Incorporated | Coated medical device |
US6770086B1 (en) | 2000-11-02 | 2004-08-03 | Scimed Life Systems, Inc. | Stent covering formed of porous polytetraflouroethylene |
DE10055686A1 (de) | 2000-11-03 | 2002-05-08 | Biotronik Mess & Therapieg | Vorrichtung zur Beeinflussung von Zellproliferationsmechanismen in Gefäßen des menschlichen oder tierischen Körpers |
CN1476362A (zh) | 2000-11-27 | 2004-02-18 | �¼��¹�����ѧ | 用于通过高温直接激光熔化制造三维金属件的方法和装置 |
US6544854B1 (en) * | 2000-11-28 | 2003-04-08 | Lsi Logic Corporation | Silicon germanium CMOS channel |
US6517888B1 (en) | 2000-11-28 | 2003-02-11 | Scimed Life Systems, Inc. | Method for manufacturing a medical device having a coated portion by laser ablation |
CN1404405A (zh) | 2000-11-30 | 2003-03-19 | 株式会社伊垣医疗设计 | 血管用斯滕特固定模和用于血管斯滕特固定模的材料 |
US7192445B2 (en) | 2000-12-06 | 2007-03-20 | Astra Tech Ab | Medical prosthetic devices and implants having improved biocompatibility |
US6545097B2 (en) * | 2000-12-12 | 2003-04-08 | Scimed Life Systems, Inc. | Drug delivery compositions and medical devices containing block copolymer |
AU2001235974A1 (en) | 2000-12-15 | 2002-06-24 | Badari Narayan Nagarada Gadde | Stent with drug-delivery system |
ES2253325T3 (es) | 2000-12-15 | 2006-06-01 | ANGIOMED GMBH & CO. MEDIZINTECHNIK KG | Protesis endovascular con valvula. |
DE10064596A1 (de) | 2000-12-18 | 2002-06-20 | Biotronik Mess & Therapieg | Verfahren zum Anbringen eines Markerelements an einem Implantat sowie mit einem Markerelement versehenes Implantat |
US20040030377A1 (en) * | 2001-10-19 | 2004-02-12 | Alexander Dubson | Medicated polymer-coated stent assembly |
US7244272B2 (en) | 2000-12-19 | 2007-07-17 | Nicast Ltd. | Vascular prosthesis and method for production thereof |
US20030050692A1 (en) * | 2000-12-22 | 2003-03-13 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
US20020082679A1 (en) | 2000-12-22 | 2002-06-27 | Avantec Vascular Corporation | Delivery or therapeutic capable agents |
US20030033007A1 (en) | 2000-12-22 | 2003-02-13 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
US7077859B2 (en) | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
US6471980B2 (en) | 2000-12-22 | 2002-10-29 | Avantec Vascular Corporation | Intravascular delivery of mycophenolic acid |
US6398806B1 (en) | 2000-12-26 | 2002-06-04 | Scimed Life Systems, Inc. | Monolayer modification to gold coated stents to reduce adsorption of protein |
US6913617B1 (en) | 2000-12-27 | 2005-07-05 | Advanced Cardiovascular Systems, Inc. | Method for creating a textured surface on an implantable medical device |
US6663662B2 (en) | 2000-12-28 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Diffusion barrier layer for implantable devices |
US6641607B1 (en) | 2000-12-29 | 2003-11-04 | Advanced Cardiovascular Systems, Inc. | Double tube stent |
US6635082B1 (en) | 2000-12-29 | 2003-10-21 | Advanced Cardiovascular Systems Inc. | Radiopaque stent |
US20020087123A1 (en) | 2001-01-02 | 2002-07-04 | Hossainy Syed F.A. | Adhesion of heparin-containing coatings to blood-contacting surfaces of medical devices |
US6544582B1 (en) | 2001-01-05 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for coating an implantable device |
DK1370306T3 (da) | 2001-01-05 | 2005-11-07 | Jacqueline Yvonne Hausdorf | Ved korrosion nedbrydelige metalliske medicinske implantater |
GB0100760D0 (en) * | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
US20010044650A1 (en) | 2001-01-12 | 2001-11-22 | Simso Eric J. | Stent for in-stent restenosis |
US20020092583A1 (en) | 2001-01-16 | 2002-07-18 | Pelton Alan R. | Medical devices, particularly stents, and methods for their manufacture |
US6752829B2 (en) | 2001-01-30 | 2004-06-22 | Scimed Life Systems, Inc. | Stent with channel(s) for containing and delivering a biologically active material and method for manufacturing the same |
US20040220660A1 (en) | 2001-02-05 | 2004-11-04 | Shanley John F. | Bioresorbable stent with beneficial agent reservoirs |
US6767360B1 (en) | 2001-02-08 | 2004-07-27 | Inflow Dynamics Inc. | Vascular stent with composite structure for magnetic reasonance imaging capabilities |
US6563080B2 (en) | 2001-02-15 | 2003-05-13 | Scimed Life Systems, Inc. | Laser cutting of stents and other medical devices |
CA2435306C (en) | 2001-02-16 | 2010-12-21 | Stephan Wnendt | Implants with fk506 |
US6998060B2 (en) | 2001-03-01 | 2006-02-14 | Cordis Corporation | Flexible stent and method of manufacture |
EP1368075B1 (en) | 2001-03-02 | 2006-04-12 | Université Laval | Plasma surface graft process for reducing thrombogenicity |
WO2002069848A2 (en) | 2001-03-06 | 2002-09-12 | Board Of Regents, The University Of Texas System | Apparatus for stent deployment with delivery of bioactive agents |
WO2002072167A1 (en) | 2001-03-13 | 2002-09-19 | Implant Sciences Corporation. | Drug eluting encapsulated stent |
BR0208116A (pt) | 2001-03-20 | 2004-03-02 | Gmp Cardiac Care Inc | Estentor de trilho |
US6913765B2 (en) | 2001-03-21 | 2005-07-05 | Scimed Life Systems, Inc. | Controlling resorption of bioresorbable medical implant material |
AU2002315263A1 (en) | 2001-03-23 | 2002-10-15 | Alcove Surfaces Gmbh | Aluminium implant and use thereof |
US20020138136A1 (en) | 2001-03-23 | 2002-09-26 | Scimed Life Systems, Inc. | Medical device having radio-opacification and barrier layers |
US6613077B2 (en) | 2001-03-27 | 2003-09-02 | Scimed Life Systems, Inc. | Stent with controlled expansion |
US6780424B2 (en) | 2001-03-30 | 2004-08-24 | Charles David Claude | Controlled morphologies in polymer drug for release of drugs from polymer films |
US6673105B1 (en) | 2001-04-02 | 2004-01-06 | Advanced Cardiovascular Systems, Inc. | Metal prosthesis coated with expandable ePTFE |
US6764505B1 (en) | 2001-04-12 | 2004-07-20 | Advanced Cardiovascular Systems, Inc. | Variable surface area stent |
US7048939B2 (en) | 2001-04-20 | 2006-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for the inhibition of neointima formation |
US7056339B2 (en) | 2001-04-20 | 2006-06-06 | The Board Of Trustees Of The Leland Stanford Junior University | Drug delivery platform |
ATE322274T1 (de) * | 2001-04-23 | 2006-04-15 | Nucryst Pharm Corp | Arzneimittel oder pflaster enthaltend ein metall wie silber gold, platin oder palladium als antimikrobiellen wirkstoff und dessen verwendung in der behandlung von hautentzündungen |
US6712845B2 (en) | 2001-04-24 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | Coating for a stent and a method of forming the same |
US7232460B2 (en) | 2001-04-25 | 2007-06-19 | Xillus, Inc. | Nanodevices, microdevices and sensors on in-vivo structures and method for the same |
US6887857B2 (en) * | 2001-04-27 | 2005-05-03 | Scimed Life Systems, Inc. | Microparticle protection of therapeutic agents |
US6660034B1 (en) | 2001-04-30 | 2003-12-09 | Advanced Cardiovascular Systems, Inc. | Stent for increasing blood flow to ischemic tissues and a method of using the same |
US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
DE60237813D1 (de) | 2001-05-11 | 2010-11-11 | Epion Corp | Verfahren zum verbessern der effektivität medizinischer einrichtungen durch anhaften von medikamenten an deren oberfläche |
US6973718B2 (en) | 2001-05-30 | 2005-12-13 | Microchips, Inc. | Methods for conformal coating and sealing microchip reservoir devices |
US6827966B2 (en) | 2001-05-30 | 2004-12-07 | Novartis Ag | Diffusion-controllable coatings on medical device |
US7862495B2 (en) | 2001-05-31 | 2011-01-04 | Advanced Cardiovascular Systems, Inc. | Radiation or drug delivery source with activity gradient to minimize edge effects |
US6712844B2 (en) | 2001-06-06 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | MRI compatible stent |
WO2002100454A1 (en) | 2001-06-11 | 2002-12-19 | Boston Scientific Limited | COMPOSITE ePTFE/TEXTILE PROSTHESIS |
US7560006B2 (en) | 2001-06-11 | 2009-07-14 | Boston Scientific Scimed, Inc. | Pressure lamination method for forming composite ePTFE/textile and ePTFE/stent/textile prostheses |
US7201940B1 (en) | 2001-06-12 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for thermal spray processing of medical devices |
US6527938B2 (en) | 2001-06-21 | 2003-03-04 | Syntheon, Llc | Method for microporous surface modification of implantable metallic medical articles |
US6844028B2 (en) | 2001-06-26 | 2005-01-18 | Accelr8 Technology Corporation | Functional surface coating |
US7727221B2 (en) | 2001-06-27 | 2010-06-01 | Cardiac Pacemakers Inc. | Method and device for electrochemical formation of therapeutic species in vivo |
US20030003127A1 (en) | 2001-06-27 | 2003-01-02 | Ethicon, Inc. | Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue |
US6656216B1 (en) * | 2001-06-29 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Composite stent with regioselective material |
US6585755B2 (en) | 2001-06-29 | 2003-07-01 | Advanced Cardiovascular | Polymeric stent suitable for imaging by MRI and fluoroscopy |
US6676987B2 (en) * | 2001-07-02 | 2004-01-13 | Scimed Life Systems, Inc. | Coating a medical appliance with a bubble jet printing head |
US20030050687A1 (en) | 2001-07-03 | 2003-03-13 | Schwade Nathan D. | Biocompatible stents and method of deployment |
EP1273314A1 (en) | 2001-07-06 | 2003-01-08 | Terumo Kabushiki Kaisha | Stent |
ATE330564T1 (de) | 2001-07-20 | 2006-07-15 | Sorin Biomedica Cardio Srl | Stent |
US6921390B2 (en) | 2001-07-23 | 2005-07-26 | Boston Scientific Scimed, Inc. | Long-term indwelling medical devices containing slow-releasing antimicrobial agents and having a surfactant surface |
US6979346B1 (en) | 2001-08-08 | 2005-12-27 | Advanced Cardiovascular Systems, Inc. | System and method for improved stent retention |
EP1414374B1 (de) | 2001-08-08 | 2005-10-26 | Arno Bücker | Magnetresonanzkompatible metallische endoprothese |
JP2003052834A (ja) | 2001-08-10 | 2003-02-25 | Medicos Hirata:Kk | 生体吸収性ステント及びその製造方法 |
GB0119652D0 (en) | 2001-08-11 | 2001-10-03 | Stanmore Implants Worldwide | Surgical implant |
US6585997B2 (en) | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
US20040249443A1 (en) | 2001-08-20 | 2004-12-09 | Shanley John F. | Expandable medical device for treating cardiac arrhythmias |
US7056338B2 (en) | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
US6632231B2 (en) | 2001-08-23 | 2003-10-14 | Scimed Life Systems, Inc. | Segmented balloon catheter blade |
GB0121980D0 (en) | 2001-09-11 | 2001-10-31 | Cathnet Science Holding As | Expandable stent |
US6589286B1 (en) | 2001-09-12 | 2003-07-08 | Jason Litner | Eustachian tube stent |
MXPA04002476A (es) | 2001-09-14 | 2004-05-31 | Anthony A Boiarski | Dispositivo de nanoporo microfabricado para la liberacion sostenida de agente terapeutico. |
US20030158598A1 (en) | 2001-09-17 | 2003-08-21 | Control Delivery Systems, Inc. | System for sustained-release delivery of anti-inflammatory agents from a coated medical device |
IN2014DN10834A (zh) | 2001-09-17 | 2015-09-04 | Psivida Inc | |
US6669980B2 (en) | 2001-09-18 | 2003-12-30 | Scimed Life Systems, Inc. | Method for spray-coating medical devices |
US20030060873A1 (en) | 2001-09-19 | 2003-03-27 | Nanomedical Technologies, Inc. | Metallic structures incorporating bioactive materials and methods for creating the same |
US7776379B2 (en) | 2001-09-19 | 2010-08-17 | Medlogics Device Corporation | Metallic structures incorporating bioactive materials and methods for creating the same |
EP1429819B1 (en) | 2001-09-24 | 2010-11-24 | Boston Scientific Limited | Optimized dosing for paclitaxel coated stents |
US6827737B2 (en) | 2001-09-25 | 2004-12-07 | Scimed Life Systems, Inc. | EPTFE covering for endovascular prostheses and method of manufacture |
JP4023597B2 (ja) | 2001-09-25 | 2007-12-19 | 独立行政法人科学技術振興機構 | 基底膜標品等を用いた再構築人工組織及びその製造方法 |
US7195640B2 (en) | 2001-09-25 | 2007-03-27 | Cordis Corporation | Coated medical devices for the treatment of vulnerable plaque |
US6753071B1 (en) | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
DE10150995A1 (de) | 2001-10-08 | 2003-04-10 | Biotronik Mess & Therapieg | Implantat mit proliferationshemmender Substanz |
WO2003070288A2 (en) * | 2001-10-12 | 2003-08-28 | Inframat Corporation | Coated implants and methods of coating implants |
US6709397B2 (en) | 2001-10-16 | 2004-03-23 | Envisioneering, L.L.C. | Scanning probe |
US7722894B2 (en) | 2001-10-22 | 2010-05-25 | Massachusetts Institute Of Technology | Biodegradable polymer |
US20030077310A1 (en) | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US8562664B2 (en) | 2001-10-25 | 2013-10-22 | Advanced Cardiovascular Systems, Inc. | Manufacture of fine-grained material for use in medical devices |
US8740973B2 (en) | 2001-10-26 | 2014-06-03 | Icon Medical Corp. | Polymer biodegradable medical device |
US20030083614A1 (en) | 2001-10-30 | 2003-05-01 | Boehringer Ingelheim Pharma Kg | Controlled release endoprosthetic device |
US20030088307A1 (en) | 2001-11-05 | 2003-05-08 | Shulze John E. | Potent coatings for stents |
US6730282B2 (en) | 2001-11-05 | 2004-05-04 | N Vara Technology S.R.L. | Sol-gel process for the manufacture of nanocomposite photoluminescent materials |
US6764709B2 (en) | 2001-11-08 | 2004-07-20 | Scimed Life Systems, Inc. | Method for making and measuring a coating on the surface of a medical device using an ultraviolet laser |
US6807440B2 (en) | 2001-11-09 | 2004-10-19 | Scimed Life Systems, Inc. | Ceramic reinforcement members for MRI devices |
EP1310242A1 (en) | 2001-11-13 | 2003-05-14 | SORIN BIOMEDICA CARDIO S.p.A. | Carrier and kit for endoluminal delivery of active principles |
US6729336B2 (en) | 2001-11-27 | 2004-05-04 | Pearl Technology Holdings, Llc | In-stent restenosis detection device |
US20030100830A1 (en) | 2001-11-27 | 2003-05-29 | Sheng-Ping Zhong | Implantable or insertable medical devices visible under magnetic resonance imaging |
US7014654B2 (en) | 2001-11-30 | 2006-03-21 | Scimed Life Systems, Inc. | Stent designed for the delivery of therapeutic substance or other agents |
US6752826B2 (en) | 2001-12-14 | 2004-06-22 | Thoratec Corporation | Layered stent-graft and methods of making the same |
FR2833684B1 (fr) * | 2001-12-18 | 2004-05-28 | Prospection & Inventions | Cartouche de gaz comprime pour appareil de fixation et coiffe d'adaptation d'un joint intermediaire |
US6939374B2 (en) | 2001-12-21 | 2005-09-06 | Scimed Life Systems, Inc. | Stents, stenting systems, and related methods for agent delivery |
DE10163107C1 (de) * | 2001-12-24 | 2003-07-10 | Univ Hannover | Magnesium-Werkstück und Verfahren zur Ausbildung einer korrosionsschützenden Deckschicht eines Magnesium-Werkstücks |
US6866805B2 (en) | 2001-12-27 | 2005-03-15 | Advanced Cardiovascular Systems, Inc. | Hybrid intravascular stent |
US6743388B2 (en) | 2001-12-31 | 2004-06-01 | Advanced Cardiovascular Systems, Inc. | Process of making polymer articles |
US20030135265A1 (en) | 2002-01-04 | 2003-07-17 | Stinson Jonathan S. | Prostheses implantable in enteral vessels |
US6506972B1 (en) | 2002-01-22 | 2003-01-14 | Nanoset, Llc | Magnetically shielded conductor |
US6864418B2 (en) | 2002-12-18 | 2005-03-08 | Nanoset, Llc | Nanomagnetically shielded substrate |
EP1476882A4 (en) | 2002-01-22 | 2007-01-17 | Nanoset Llc | NANOMAGNETIC SHIELD SUBSTRATE |
US6906256B1 (en) | 2002-01-22 | 2005-06-14 | Nanoset, Llc | Nanomagnetic shielding assembly |
WO2003062824A1 (en) | 2002-01-23 | 2003-07-31 | Boditech Inc. | Lateral flow quantitative assay method and strip and laser-induced fluoerescence detection device therefor |
US7060089B2 (en) | 2002-01-23 | 2006-06-13 | Boston Scientific Scimed, Inc. | Multi-layer stent |
US7011678B2 (en) * | 2002-01-31 | 2006-03-14 | Radi Medical Systems Ab | Biodegradable stent |
US7326245B2 (en) | 2002-01-31 | 2008-02-05 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US20030153901A1 (en) | 2002-02-08 | 2003-08-14 | Atrium Medical Corporation | Drug delivery panel |
US6887270B2 (en) * | 2002-02-08 | 2005-05-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
KR20040097126A (ko) | 2002-02-15 | 2004-11-17 | 씨브이 쎄러퓨틱스, 인코포레이티드 | 의료 장치용 중합체 코팅 |
DE10207161B4 (de) | 2002-02-20 | 2004-12-30 | Universität Hannover | Verfahren zur Herstellung von Implantaten |
JP2003250880A (ja) | 2002-02-28 | 2003-09-09 | Ube Ind Ltd | 人工血管 |
US20030170605A1 (en) | 2002-03-11 | 2003-09-11 | Egan Visual Inc. | Vapor deposited writing surfaces |
US6586705B1 (en) | 2002-03-15 | 2003-07-01 | The Boeing Company | Anti-spatter tube |
US7022334B1 (en) | 2002-03-20 | 2006-04-04 | Advanced Cardiovascular Systems, Inc. | Therapeutic composition and a method of coating implantable medical devices |
US7927368B2 (en) | 2002-03-25 | 2011-04-19 | Kieran Murphy Llc | Device viewable under an imaging beam |
US6743463B2 (en) | 2002-03-28 | 2004-06-01 | Scimed Life Systems, Inc. | Method for spray-coating a medical device having a tubular wall such as a stent |
EP1348402A1 (en) | 2002-03-29 | 2003-10-01 | Advanced Laser Applications Holding S.A. | Intraluminal endoprosthesis, radially expandable, perforated for drug delivery |
US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
US7799467B2 (en) | 2002-04-08 | 2010-09-21 | Massachusetts Institute Of Technology | Solid polymer electrolytes from ethylene oxide-containing, layer-by-layer assembled films |
US20030211135A1 (en) | 2002-04-11 | 2003-11-13 | Greenhalgh Skott E. | Stent having electrospun covering and method |
US20050187605A1 (en) | 2002-04-11 | 2005-08-25 | Greenhalgh Skott E. | Electrospun skin capable of controlling drug release rates and method |
US20030204239A1 (en) | 2002-04-26 | 2003-10-30 | Wenda Carlyle | Endovascular stent with a preservative coating |
AU2003228858A1 (en) | 2002-05-02 | 2003-11-17 | Scimed Life Systems, Inc. | Energetically-controlled delivery of biologically active material from an implanted medical device |
WO2003092554A1 (en) | 2002-05-03 | 2003-11-13 | The General Hospital Corporation | Involuted endovascular valve and method of construction |
CN1655738A (zh) | 2002-05-20 | 2005-08-17 | 奥勃斯医学技术股份有限公司 | 可植入的药物洗脱医疗装置 |
US20040000540A1 (en) | 2002-05-23 | 2004-01-01 | Soboyejo Winston O. | Laser texturing of surfaces for biomedical implants |
US7048767B2 (en) | 2002-06-11 | 2006-05-23 | Spire Corporation | Nano-crystalline, homo-metallic, protective coatings |
US20030236513A1 (en) | 2002-06-19 | 2003-12-25 | Scimed Life Systems, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
US7789908B2 (en) | 2002-06-25 | 2010-09-07 | Boston Scientific Scimed, Inc. | Elastomerically impregnated ePTFE to enhance stretch and recovery properties for vascular grafts and coverings |
US6865810B2 (en) | 2002-06-27 | 2005-03-15 | Scimed Life Systems, Inc. | Methods of making medical devices |
US6696666B2 (en) * | 2002-07-03 | 2004-02-24 | Scimed Life Systems, Inc. | Tubular cutting process and system |
US20040004063A1 (en) * | 2002-07-08 | 2004-01-08 | Merdan Kenneth M. | Vertical stent cutting process |
AU2003250913A1 (en) | 2002-07-08 | 2004-01-23 | Abbott Laboratories Vascular Enterprises Limited | Drug eluting stent and methods of manufacture |
US20050096731A1 (en) | 2002-07-11 | 2005-05-05 | Kareen Looi | Cell seeded expandable body |
EP1382408B1 (en) | 2002-07-15 | 2010-06-23 | Hitachi Metals, Ltd. | Method for producing porous sintered metals for filters |
US20040137039A1 (en) | 2002-07-22 | 2004-07-15 | Trustees Of Stevens Institute Of Technology | Methods for controlled release of molecules from layered polymer films |
US7067606B2 (en) | 2002-07-30 | 2006-06-27 | University Of Connecticut | Nonionic telechelic polymers incorporating polyhedral oligosilsesquioxane (POSS) and uses thereof |
DE10235689A1 (de) | 2002-07-31 | 2004-02-19 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Endovaskuläres Implantat zur Injektion eines Wirkstoffs in die Media eines Blutgefäßes |
US20050163821A1 (en) | 2002-08-02 | 2005-07-28 | Hsing-Wen Sung | Drug-eluting Biodegradable Stent and Delivery Means |
US20040024448A1 (en) | 2002-08-05 | 2004-02-05 | Chang James W. | Thermoplastic fluoropolymer-coated medical devices |
US7255710B2 (en) | 2002-08-06 | 2007-08-14 | Icon Medical Corp. | Helical stent with micro-latches |
US6962822B2 (en) | 2002-08-07 | 2005-11-08 | International Business Machines Corporation | Discrete nano-textured structures in biomolecular arrays, and method of use |
DE10237572A1 (de) | 2002-08-13 | 2004-02-26 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Stent mit polymerer Beschichtung |
DE10237571A1 (de) | 2002-08-13 | 2004-02-26 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Endovaskuläres Implantat mit aktiver Beschichtung |
EP1550477B1 (en) | 2002-08-23 | 2015-11-04 | National Cerebral and Cardiovascular Center | Stent and process for producing the same |
US7029495B2 (en) | 2002-08-28 | 2006-04-18 | Scimed Life Systems, Inc. | Medical devices and methods of making the same |
US6951053B2 (en) | 2002-09-04 | 2005-10-04 | Reva Medical, Inc. | Method of manufacturing a prosthesis |
US6896926B2 (en) | 2002-09-11 | 2005-05-24 | Novartis Ag | Method for applying an LbL coating onto a medical device |
EP1539270A1 (en) | 2002-09-18 | 2005-06-15 | Medtronic Vascular, Inc. | Controllable drug releasing gradient coatings for medical devices |
ATE392864T1 (de) | 2002-09-20 | 2008-05-15 | Abbott Lab Vascular Entpr Ltd | Mit einer rauhen oberfläche versehener stent und sein herstellungsverfahren |
US7758636B2 (en) | 2002-09-20 | 2010-07-20 | Innovational Holdings Llc | Expandable medical device with openings for delivery of multiple beneficial agents |
US7001422B2 (en) | 2002-09-23 | 2006-02-21 | Cordis Neurovascular, Inc | Expandable stent and delivery system |
US20040059409A1 (en) | 2002-09-24 | 2004-03-25 | Stenzel Eric B. | Method of applying coatings to a medical device |
US7060051B2 (en) | 2002-09-24 | 2006-06-13 | Scimed Life Systems, Inc. | Multi-balloon catheter with hydrogel coating |
EP1551569B1 (en) | 2002-09-26 | 2017-05-10 | Advanced Bio Prosthetic Surfaces, Ltd. | Implantable materials having engineered surfaces and method of making same |
US6971813B2 (en) | 2002-09-27 | 2005-12-06 | Labcoat, Ltd. | Contact coating of prostheses |
EP1548138A4 (en) | 2002-09-30 | 2007-07-18 | Nano Technology Inst Inc | NANOCRYSTALLINE AUSTENITIC METAL MATERIAL IN BULK HAVING HIGH HARDNESS, RESISTANCE AND TENACITY, AND PROCESS FOR PRODUCING THE SAME |
US6770729B2 (en) | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
DE60336158D1 (de) * | 2002-10-11 | 2011-04-07 | Univ Connecticut | Auf semikristalline thermoplastische polyurethane die nanostrukturierte hartsegmente aufweisen basierenden formgedächtnispolymere |
US7794494B2 (en) | 2002-10-11 | 2010-09-14 | Boston Scientific Scimed, Inc. | Implantable medical devices |
US7976936B2 (en) | 2002-10-11 | 2011-07-12 | University Of Connecticut | Endoprostheses |
US20060271168A1 (en) | 2002-10-30 | 2006-11-30 | Klaus Kleine | Degradable medical device |
US20040088038A1 (en) | 2002-10-30 | 2004-05-06 | Houdin Dehnad | Porous metal for drug-loaded stents |
SE0203224D0 (sv) | 2002-10-31 | 2002-10-31 | Cerbio Tech Ab | Method of making structured ceramic coatings and coated devices prepared with the method |
US8221495B2 (en) | 2002-11-07 | 2012-07-17 | Abbott Laboratories | Integration of therapeutic agent into a bioerodible medical device |
US20040142014A1 (en) | 2002-11-08 | 2004-07-22 | Conor Medsystems, Inc. | Method and apparatus for reducing tissue damage after ischemic injury |
JP2006505364A (ja) | 2002-11-08 | 2006-02-16 | コナー メドシステムズ, インコーポレイテッド | 血管新生因子の局所供給を用いる、慢性全梗塞を処置するための拡張可能な医療装置および方法 |
US7169178B1 (en) | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
US20060121080A1 (en) | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
DE10253633B4 (de) | 2002-11-13 | 2011-08-11 | BIOTRONIK GmbH & Co. KG, 12359 | Tragstruktur |
US7144422B1 (en) | 2002-11-13 | 2006-12-05 | Advanced Cardiovascular Systems, Inc. | Drug-eluting stent and methods of making the same |
DE10253634A1 (de) | 2002-11-13 | 2004-05-27 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Endoprothese |
KR100826574B1 (ko) | 2002-11-13 | 2008-04-30 | 유니버시티 오브 버지니아 페이턴트 파운데이션 | 다공성 층을 갖는 의료장치 및 이를 제조하는 방법 |
US20050070989A1 (en) | 2002-11-13 | 2005-03-31 | Whye-Kei Lye | Medical devices having porous layers and methods for making the same |
US20050187615A1 (en) | 2004-02-23 | 2005-08-25 | Williams Michael S. | Polymeric endoprostheses with enhanced strength and flexibility and methods of manufacture |
EP1567221A1 (en) | 2002-11-15 | 2005-08-31 | GMP Cardiac Care, Inc. | Rail stent |
US8449601B2 (en) | 2002-11-19 | 2013-05-28 | Boston Scientific Scimed, Inc. | Medical devices |
US6696667B1 (en) * | 2002-11-22 | 2004-02-24 | Scimed Life Systems, Inc. | Laser stent cutting |
JP4119230B2 (ja) | 2002-11-26 | 2008-07-16 | 株式会社 日立ディスプレイズ | 表示装置 |
US6918869B2 (en) | 2002-12-02 | 2005-07-19 | Scimed Life Systems | System for administering a combination of therapies to a body lumen |
US7776926B1 (en) | 2002-12-11 | 2010-08-17 | Advanced Cardiovascular Systems, Inc. | Biocompatible coating for implantable medical devices |
DE10261822A1 (de) | 2002-12-20 | 2004-07-01 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Helix-Steg-Verbindung |
US6926735B2 (en) | 2002-12-23 | 2005-08-09 | Scimed Life Systems, Inc. | Multi-lumen vascular grafts having improved self-sealing properties |
US7666216B2 (en) | 2002-12-24 | 2010-02-23 | Novostent Corporation | Delivery catheter for ribbon-type prosthesis and methods of use |
US7846198B2 (en) | 2002-12-24 | 2010-12-07 | Novostent Corporation | Vascular prosthesis and methods of use |
US6725901B1 (en) | 2002-12-27 | 2004-04-27 | Advanced Cardiovascular Systems, Inc. | Methods of manufacture of fully consolidated or porous medical devices |
US6803070B2 (en) | 2002-12-30 | 2004-10-12 | Scimed Life Systems, Inc. | Apparatus and method for embedding nanoparticles in polymeric medical devices |
US7105018B1 (en) | 2002-12-30 | 2006-09-12 | Advanced Cardiovascular Systems, Inc. | Drug-eluting stent cover and method of use |
US7316710B1 (en) | 2002-12-30 | 2008-01-08 | Advanced Cardiovascular Systems, Inc. | Flexible stent |
US6896697B1 (en) | 2002-12-30 | 2005-05-24 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
WO2004060405A2 (en) | 2002-12-30 | 2004-07-22 | Angiotech International Ag | Tissue reactive compounds and compositions and uses thereof |
US20040236415A1 (en) | 2003-01-02 | 2004-11-25 | Richard Thomas | Medical devices having drug releasing polymer reservoirs |
US20040143317A1 (en) | 2003-01-17 | 2004-07-22 | Stinson Jonathan S. | Medical devices |
US6852122B2 (en) | 2003-01-23 | 2005-02-08 | Cordis Corporation | Coated endovascular AAA device |
EP1610752B1 (en) | 2003-01-31 | 2013-01-02 | Boston Scientific Limited | Localized drug delivery using drug-loaded nanocapsules and implantable device coated with the same |
US7311727B2 (en) | 2003-02-05 | 2007-12-25 | Board Of Trustees Of The University Of Arkansas | Encased stent |
US7172624B2 (en) | 2003-02-06 | 2007-02-06 | Boston Scientific Scimed, Inc. | Medical device with magnetic resonance visibility enhancing structure |
US20080038146A1 (en) | 2003-02-10 | 2008-02-14 | Jurgen Wachter | Metal alloy for medical devices and implants |
FR2851181B1 (fr) | 2003-02-17 | 2006-05-26 | Commissariat Energie Atomique | Procede de revetement d'une surface |
US20050079199A1 (en) | 2003-02-18 | 2005-04-14 | Medtronic, Inc. | Porous coatings for drug release from medical devices |
AU2004213021B2 (en) | 2003-02-18 | 2010-12-09 | Medtronic, Inc. | Occlusion resistant hydrocephalic shunt |
US20040167572A1 (en) | 2003-02-20 | 2004-08-26 | Roth Noah M. | Coated medical devices |
ES2354605T3 (es) | 2003-02-21 | 2011-03-16 | Sorin Biomedica Cardio S.R.L. | Procedimiento de producción de stents y el stent correspondiente. |
US7942920B2 (en) | 2003-02-25 | 2011-05-17 | Cordis Corporation | Stent with nested fingers for enhanced vessel coverage |
US20080051866A1 (en) * | 2003-02-26 | 2008-02-28 | Chao Chin Chen | Drug delivery devices and methods |
US7001421B2 (en) | 2003-02-28 | 2006-02-21 | Medtronic Vascular, Inc. | Stent with phenoxy primer coating |
US6699282B1 (en) | 2003-03-06 | 2004-03-02 | Gelsus Research And Consulting, Inc. | Method and apparatus for delivery of medication |
US6932930B2 (en) | 2003-03-10 | 2005-08-23 | Synecor, Llc | Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same |
US8281737B2 (en) | 2003-03-10 | 2012-10-09 | Boston Scientific Scimed, Inc. | Coated medical device and method for manufacturing the same |
DE10311729A1 (de) * | 2003-03-18 | 2004-09-30 | Schultheiss, Heinz-Peter, Prof. Dr. | Endovaskuläres Implantat mit einer mindestens abschnittsweisen aktiven Beschichtung aus Ratjadon und/oder einem Ratjadon-Derivat |
US20040202692A1 (en) | 2003-03-28 | 2004-10-14 | Conor Medsystems, Inc. | Implantable medical device and method for in situ selective modulation of agent delivery |
US20050022627A1 (en) | 2003-04-03 | 2005-02-03 | Cheng-Han Chen | Oxidation resistant treatment for metallic medical devices |
US20050079132A1 (en) * | 2003-04-08 | 2005-04-14 | Xingwu Wang | Medical device with low magnetic susceptibility |
US20050070996A1 (en) | 2003-04-08 | 2005-03-31 | Dinh Thomas Q. | Drug-eluting stent for controlled drug delivery |
US20040254419A1 (en) | 2003-04-08 | 2004-12-16 | Xingwu Wang | Therapeutic assembly |
US20050216075A1 (en) | 2003-04-08 | 2005-09-29 | Xingwu Wang | Materials and devices of enhanced electromagnetic transparency |
US20050107870A1 (en) | 2003-04-08 | 2005-05-19 | Xingwu Wang | Medical device with multiple coating layers |
US7163555B2 (en) | 2003-04-08 | 2007-01-16 | Medtronic Vascular, Inc. | Drug-eluting stent for controlled drug delivery |
US20050149169A1 (en) | 2003-04-08 | 2005-07-07 | Xingwu Wang | Implantable medical device |
US7717953B2 (en) | 2004-10-13 | 2010-05-18 | Tryton Medical, Inc. | Delivery system for placement of prosthesis at luminal OS |
US7731747B2 (en) | 2003-04-14 | 2010-06-08 | Tryton Medical, Inc. | Vascular bifurcation prosthesis with multiple thin fronds |
US20060041182A1 (en) * | 2003-04-16 | 2006-02-23 | Forbes Zachary G | Magnetically-controllable delivery system for therapeutic agents |
US20050221072A1 (en) | 2003-04-17 | 2005-10-06 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
US20040230176A1 (en) | 2003-04-23 | 2004-11-18 | Medtronic Vascular, Inc. | System for treating a vascular condition that inhibits restenosis at stent ends |
JP4734236B2 (ja) | 2003-04-25 | 2011-07-27 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 固形型の薬物の貯蔵及び制御された放出のための装置及びその製造方法 |
ATE476960T1 (de) | 2003-05-02 | 2010-08-15 | Surmodics Inc | System zur kontrollierten freisetzung eines bioaktiven wirkstoffs im hinteren bereich des auges |
US8246974B2 (en) | 2003-05-02 | 2012-08-21 | Surmodics, Inc. | Medical devices and methods for producing the same |
US6923996B2 (en) | 2003-05-06 | 2005-08-02 | Scimed Life Systems, Inc. | Processes for producing polymer coatings for release of therapeutic agent |
US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
US6846323B2 (en) | 2003-05-15 | 2005-01-25 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
US20040230290A1 (en) | 2003-05-15 | 2004-11-18 | Jan Weber | Medical devices and methods of making the same |
AU2004238517A1 (en) | 2003-05-16 | 2004-11-25 | Cinvention Ag | Method for coating substrates with a carbon-based material |
US20040236416A1 (en) | 2003-05-20 | 2004-11-25 | Robert Falotico | Increased biocompatibility of implantable medical devices |
DE10323628A1 (de) | 2003-05-20 | 2004-12-30 | Biotronik Ag | Stents aus einem Material geringer Bruchdehnung |
US20050211680A1 (en) | 2003-05-23 | 2005-09-29 | Mingwei Li | Systems and methods for laser texturing of surfaces of a substrate |
US7297644B2 (en) | 2003-05-28 | 2007-11-20 | Air Products Polymers, L.P. | Nonwoven binders with high wet/dry tensile strength ratio |
US20030216803A1 (en) | 2003-05-28 | 2003-11-20 | Ledergerber Walter J. | Textured and drug eluting stent-grafts |
US7041127B2 (en) | 2003-05-28 | 2006-05-09 | Ledergerber Walter J | Textured and drug eluting coronary artery stent |
US7270679B2 (en) | 2003-05-30 | 2007-09-18 | Warsaw Orthopedic, Inc. | Implants based on engineered metal matrix composite materials having enhanced imaging and wear resistance |
US6904658B2 (en) | 2003-06-02 | 2005-06-14 | Electroformed Stents, Inc. | Process for forming a porous drug delivery layer |
US6979348B2 (en) | 2003-06-04 | 2005-12-27 | Medtronic Vascular, Inc. | Reflowed drug-polymer coated stent and method thereof |
US7169179B2 (en) | 2003-06-05 | 2007-01-30 | Conor Medsystems, Inc. | Drug delivery device and method for bi-directional drug delivery |
EP1650868A1 (en) | 2003-07-02 | 2006-04-26 | Sony Corporation | Mems type oscillator, process for fabricating the same, filter, and communication unit |
FI20045223A (fi) * | 2004-06-15 | 2005-12-16 | Bioretec Oy | Monitoiminen biohajoava komposiitti ja kirurginen implantti, joka käsittää mainitun komposiitin |
US20050021127A1 (en) | 2003-07-21 | 2005-01-27 | Kawula Paul John | Porous glass fused onto stent for drug retention |
US20050021128A1 (en) | 2003-07-24 | 2005-01-27 | Medtronic Vascular, Inc. | Compliant, porous, rolled stent |
US7682603B2 (en) | 2003-07-25 | 2010-03-23 | The Trustees Of The University Of Pennsylvania | Polymersomes incorporating highly emissive probes |
WO2005012530A2 (en) | 2003-07-25 | 2005-02-10 | Amgen Inc. | Antagonists and agonists of ldcam and methods of use |
US20050025805A1 (en) * | 2003-07-28 | 2005-02-03 | Adam Heller | Osmium compounds for reduction of adverse inflammation |
US20050027350A1 (en) * | 2003-07-30 | 2005-02-03 | Biotronik Mess-Und Therapiegeraete Gmbh & Co Ingenieurbuero Berlin | Endovascular implant for the injection of an active substance into the media of a blood vessel |
US20050033417A1 (en) | 2003-07-31 | 2005-02-10 | John Borges | Coating for controlled release of a therapeutic agent |
US20070038289A1 (en) | 2003-08-05 | 2007-02-15 | Kaneka Corporation | Stent to be placed in vivo |
US7479157B2 (en) * | 2003-08-07 | 2009-01-20 | Boston Scientific Scimed, Inc. | Stent designs which enable the visibility of the inside of the stent during MRI |
US20050037047A1 (en) | 2003-08-11 | 2005-02-17 | Young-Ho Song | Medical devices comprising spray dried microparticles |
US7364585B2 (en) | 2003-08-11 | 2008-04-29 | Boston Scientific Scimed, Inc. | Medical devices comprising drug-loaded capsules for localized drug delivery |
US20050038501A1 (en) | 2003-08-12 | 2005-02-17 | Moore James E. | Dynamic stent |
US20050055085A1 (en) | 2003-09-04 | 2005-03-10 | Rivron Nicolas C. | Implantable medical devices having recesses |
US20050055080A1 (en) | 2003-09-05 | 2005-03-10 | Naim Istephanous | Modulated stents and methods of making the stents |
US7544381B2 (en) | 2003-09-09 | 2009-06-09 | Boston Scientific Scimed, Inc. | Lubricious coatings for medical device |
WO2005025449A2 (en) | 2003-09-10 | 2005-03-24 | Spheric Products, Ltd | Cardiovascular stent with anti-platelet and angiogenic material |
US7488343B2 (en) | 2003-09-16 | 2009-02-10 | Boston Scientific Scimed, Inc. | Medical devices |
US20050060020A1 (en) | 2003-09-17 | 2005-03-17 | Scimed Life Systems, Inc. | Covered stent with biologically active material |
CN101094622A (zh) | 2003-09-18 | 2007-12-26 | 先进生物假体表面有限公司 | 具有MEMs功能的医疗装置及其制造方法 |
US7060319B2 (en) | 2003-09-24 | 2006-06-13 | Boston Scientific Scimed, Inc. | method for using an ultrasonic nozzle to coat a medical appliance |
US8801692B2 (en) * | 2003-09-24 | 2014-08-12 | Medtronic Vascular, Inc. | Gradient coated stent and method of fabrication |
US20050070990A1 (en) | 2003-09-26 | 2005-03-31 | Stinson Jonathan S. | Medical devices and methods of making same |
US7055237B2 (en) | 2003-09-29 | 2006-06-06 | Medtronic Vascular, Inc. | Method of forming a drug eluting stent |
US7198675B2 (en) | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
US7618647B2 (en) | 2003-10-03 | 2009-11-17 | Boston Scientific Scimed, Inc. | Using bucky paper as a therapeutic aid in medical applications |
US7284677B2 (en) | 2003-10-08 | 2007-10-23 | Elizabeth Ann Guevara | Bottle holding appliance and method for its use |
US20050113936A1 (en) | 2003-10-30 | 2005-05-26 | Brustad John R. | Surface treatments and modifications using nanostructure materials |
US7208172B2 (en) | 2003-11-03 | 2007-04-24 | Medlogics Device Corporation | Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices |
US20050129731A1 (en) | 2003-11-03 | 2005-06-16 | Roland Horres | Biocompatible, biostable coating of medical surfaces |
US20050100577A1 (en) | 2003-11-10 | 2005-05-12 | Parker Theodore L. | Expandable medical device with beneficial agent matrix formed by a multi solvent system |
CA2536168A1 (en) | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Intravascular devices and fibrosis-inducing agents |
EP1689811B1 (en) | 2003-11-14 | 2019-01-23 | Wild River Consulting Group, LLC | Enhanced property metal polymer composite |
US20050113904A1 (en) | 2003-11-25 | 2005-05-26 | Shank Peter J. | Composite stent with inner and outer stent elements and method of using the same |
US20050119723A1 (en) | 2003-11-28 | 2005-06-02 | Medlogics Device Corporation | Medical device with porous surface containing bioerodable bioactive composites and related methods |
EP1535952B1 (en) | 2003-11-28 | 2013-01-16 | Universite Louis Pasteur | Method for preparing crosslinked polyelectrolyte multilayer films |
US20060085062A1 (en) | 2003-11-28 | 2006-04-20 | Medlogics Device Corporation | Implantable stent with endothelialization factor |
DE10357281A1 (de) | 2003-12-05 | 2005-07-14 | Hassel, Thomas, Dipl.-Ing. | Gefäßstütze |
DE10357334A1 (de) | 2003-12-05 | 2005-07-07 | Grönemeyer, Dietrich H. W., Prof. Dr.med. | MR-kompatibles medizinisches Implantat |
US20050131522A1 (en) | 2003-12-10 | 2005-06-16 | Stinson Jonathan S. | Medical devices and methods of making the same |
EP1691858B1 (en) | 2003-12-12 | 2017-05-17 | C.R.Bard, Inc. | Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof |
DE10358502B3 (de) | 2003-12-13 | 2005-04-07 | Daimlerchrysler Ag | Verfahren und Einrichtung zur Herstellung eines Hohlprofils |
US8017178B2 (en) | 2003-12-16 | 2011-09-13 | Cardiac Pacemakers, Inc. | Coatings for implantable electrodes |
US7220816B2 (en) | 2003-12-16 | 2007-05-22 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same |
US20050137684A1 (en) | 2003-12-17 | 2005-06-23 | Pfizer Inc | Stent with therapeutically active drug coated thereon |
US20050137677A1 (en) | 2003-12-17 | 2005-06-23 | Rush Scott L. | Endovascular graft with differentiable porosity along its length |
US7208134B2 (en) | 2003-12-18 | 2007-04-24 | Massachusetts Institute Of Technology | Bioprocesses enhanced by magnetic nanoparticles |
US8652502B2 (en) | 2003-12-19 | 2014-02-18 | Cordis Corporation | Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury |
US7261732B2 (en) | 2003-12-22 | 2007-08-28 | Henri Justino | Stent mounted valve |
US20070027532A1 (en) | 2003-12-22 | 2007-02-01 | Xingwu Wang | Medical device |
DE10361941A1 (de) | 2003-12-24 | 2005-07-28 | Restate Patent Ag | Magnesiumhaltige Beschichtung |
DE10361940A1 (de) | 2003-12-24 | 2005-07-28 | Restate Patent Ag | Degradationssteuerung biodegradierbarer Implantate durch Beschichtung |
WO2005064026A1 (fr) * | 2003-12-25 | 2005-07-14 | Institute Of Metal Research Chinese Academy Of Sciences | Alliages ti a faible module et super-elasticite, procede de production correspondant |
WO2005070338A1 (en) | 2004-01-20 | 2005-08-04 | Cook Incorporated | Multiple stitches for attaching stent to graft |
US20050159805A1 (en) | 2004-01-20 | 2005-07-21 | Jan Weber | Functional coatings and designs for medical implants |
US20050159809A1 (en) | 2004-01-21 | 2005-07-21 | Medtronic Vascular, Inc. | Implantable medical devices for treating or preventing restenosis |
US7854756B2 (en) | 2004-01-22 | 2010-12-21 | Boston Scientific Scimed, Inc. | Medical devices |
US7632299B2 (en) | 2004-01-22 | 2009-12-15 | Boston Scientific Scimed, Inc. | Medical devices |
US8620406B2 (en) | 2004-01-23 | 2013-12-31 | Boston Scientific Scimed, Inc. | Medical devices visible by magnetic resonance imaging |
US7393589B2 (en) | 2004-01-30 | 2008-07-01 | Ionbond, Inc. | Dual layer diffusion bonded chemical vapor coating for medical implants |
ITTO20040056A1 (it) | 2004-02-05 | 2004-05-05 | Sorin Biomedica Cardio Spa | Stent per l'erogazione endoliminale di principi o agenti attivi |
DE102004029611A1 (de) | 2004-02-06 | 2005-08-25 | Restate Patent Ag | Implantat zur Freisetzung eines Wirkstoffs in ein von einem Körpermedium durchströmtes Gefäß |
US7442681B2 (en) | 2004-02-10 | 2008-10-28 | University Of Virginia Patent Foundation | Method of inhibiting vascular permeability |
US8057841B2 (en) | 2004-02-12 | 2011-11-15 | University Of Akron | Mechanically attached medical device coatings |
US20050180919A1 (en) | 2004-02-12 | 2005-08-18 | Eugene Tedeschi | Stent with radiopaque and encapsulant coatings |
US8049137B2 (en) | 2004-02-13 | 2011-11-01 | Boston Scientific Scimed, Inc. | Laser shock peening of medical devices |
US8137397B2 (en) | 2004-02-26 | 2012-03-20 | Boston Scientific Scimed, Inc. | Medical devices |
US7294145B2 (en) | 2004-02-26 | 2007-11-13 | Boston Scientific Scimed, Inc. | Stent with differently coated inside and outside surfaces |
US6979473B2 (en) | 2004-03-15 | 2005-12-27 | Boston Scientific Scimed, Inc. | Method for fine bore orifice spray coating of medical devices and pre-filming atomization |
US7744644B2 (en) | 2004-03-19 | 2010-06-29 | Boston Scientific Scimed, Inc. | Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release |
US8435287B2 (en) | 2004-03-30 | 2013-05-07 | Toyo Advanced Technologies Co., Ltd. | Stent and method for fabricating the same |
US8715340B2 (en) | 2004-03-31 | 2014-05-06 | Merlin Md Pte Ltd. | Endovascular device with membrane |
US20050222671A1 (en) | 2004-03-31 | 2005-10-06 | Schaeffer Darin G | Partially biodegradable stent |
US20050220853A1 (en) | 2004-04-02 | 2005-10-06 | Kinh-Luan Dao | Controlled delivery of therapeutic agents from medical articles |
CN1964748A (zh) | 2004-04-06 | 2007-05-16 | 苏莫迪克斯公司 | 用于生物活性剂的涂料组合物 |
US20050228477A1 (en) | 2004-04-09 | 2005-10-13 | Xtent, Inc. | Topographic coatings and coating methods for medical devices |
US20050228491A1 (en) | 2004-04-12 | 2005-10-13 | Snyder Alan J | Anti-adhesive surface treatments |
CA2502018A1 (en) | 2004-04-16 | 2005-10-16 | Conor Medsystems, Inc. | Bioresorbable stent delivery system |
US7470247B2 (en) * | 2004-04-26 | 2008-12-30 | Gyrus Acmi, Inc. | Ureteral stent |
US7070576B2 (en) | 2004-04-30 | 2006-07-04 | Boston Scientific Scimed, Inc. | Directional cutting balloon |
US20050251245A1 (en) | 2004-05-05 | 2005-11-10 | Karl Sieradzki | Methods and apparatus with porous materials |
US7955371B2 (en) | 2004-05-12 | 2011-06-07 | Medtronic Vascular, Inc. | System and method for stent deployment and infusion of a therapeutic agent into tissue adjacent to the stent ends |
US7758892B1 (en) | 2004-05-20 | 2010-07-20 | Boston Scientific Scimed, Inc. | Medical devices having multiple layers |
US20060100696A1 (en) * | 2004-11-10 | 2006-05-11 | Atanasoska Ljiljana L | Medical devices and methods of making the same |
DE602005002745T2 (de) | 2004-05-20 | 2008-07-17 | Boston Scientific Ltd., Barbados | Medizinische vorrichtungen und verfahren zu ihrer herstellung |
ES2357243T3 (es) | 2004-05-21 | 2011-04-20 | Micro Therapeutics, Inc. | Espirales metálicas entrelazadas con polímeros o fibras biológicos o biodegradables o sintéticos para la embolización de una cavidad corporal. |
DE102004026104A1 (de) | 2004-05-25 | 2005-12-15 | Restate Patent Ag | Implantat zur Gefäßligatur |
US20050266039A1 (en) | 2004-05-27 | 2005-12-01 | Jan Weber | Coated medical device and method for making the same |
WO2005118019A1 (en) | 2004-05-28 | 2005-12-15 | Cook Incorporated | Implantable bioabsorbable valve support frame |
US20050266040A1 (en) | 2004-05-28 | 2005-12-01 | Brent Gerberding | Medical devices composed of porous metallic materials for delivering biologically active materials |
US7695775B2 (en) | 2004-06-04 | 2010-04-13 | Applied Microstructures, Inc. | Controlled vapor deposition of biocompatible coatings over surface-treated substrates |
US7794490B2 (en) | 2004-06-22 | 2010-09-14 | Boston Scientific Scimed, Inc. | Implantable medical devices with antimicrobial and biodegradable matrices |
EP2111881A1 (en) | 2004-07-05 | 2009-10-28 | Ziscoat N.V. | Biocompatible coating of medical devices comprising molecular sieves |
US20060009839A1 (en) | 2004-07-12 | 2006-01-12 | Scimed Life Systems, Inc. | Composite vascular graft including bioactive agent coating and biodegradable sheath |
US7078108B2 (en) * | 2004-07-14 | 2006-07-18 | The Regents Of The University Of California | Preparation of high-strength nanometer scale twinned coating and foil |
US20060015361A1 (en) | 2004-07-16 | 2006-01-19 | Jurgen Sattler | Method and system for customer contact reporting |
US7269700B2 (en) | 2004-07-26 | 2007-09-11 | Integrated Device Technology, Inc. | Status bus accessing only available quadrants during loop mode operation in a multi-queue first-in first-out memory system |
US20060025848A1 (en) * | 2004-07-29 | 2006-02-02 | Jan Weber | Medical device having a coating layer with structural elements therein and method of making the same |
DE102004038446A1 (de) * | 2004-08-07 | 2006-03-16 | Ina-Schaeffler Kg | Schaltbares Ventiltriebselement einer Brennkraftmaschine |
US20060275554A1 (en) | 2004-08-23 | 2006-12-07 | Zhibo Zhao | High performance kinetic spray nozzle |
US7507433B2 (en) | 2004-09-03 | 2009-03-24 | Boston Scientific Scimed, Inc. | Method of coating a medical device using an electrowetting process |
DE102004043231A1 (de) | 2004-09-07 | 2006-03-09 | Biotronik Vi Patent Ag | Endoprothese aus einer Magnesiumlegierung |
DE502005008226D1 (de) | 2004-09-07 | 2009-11-12 | Biotronik Vi Patent Ag | Endoprothese aus einer Magnesiumlegierung |
DE102004043232A1 (de) | 2004-09-07 | 2006-03-09 | Biotronik Vi Patent Ag | Endoprothese aus einer Magnesiumlegierung |
DE102004044679A1 (de) | 2004-09-09 | 2006-03-16 | Biotronik Vi Patent Ag | Implantat mit geringer Radialfestigkeit |
US7229471B2 (en) * | 2004-09-10 | 2007-06-12 | Advanced Cardiovascular Systems, Inc. | Compositions containing fast-leaching plasticizers for improved performance of medical devices |
US7473278B2 (en) * | 2004-09-16 | 2009-01-06 | Smith & Nephew, Inc. | Method of surface oxidizing zirconium and zirconium alloys and resulting product |
US7901451B2 (en) | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US9011831B2 (en) * | 2004-09-30 | 2015-04-21 | Advanced Cardiovascular Systems, Inc. | Methacrylate copolymers for medical devices |
US20060075044A1 (en) | 2004-09-30 | 2006-04-06 | Fox Kevin D | System and method for electronic contact list-based search and display |
US20060075092A1 (en) | 2004-10-06 | 2006-04-06 | Kabushiki Kaisha Toshiba | System and method for determining the status of users and devices from access log information |
US7344560B2 (en) * | 2004-10-08 | 2008-03-18 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US20060085065A1 (en) * | 2004-10-15 | 2006-04-20 | Krause Arthur A | Stent with auxiliary treatment structure |
US7862835B2 (en) | 2004-10-27 | 2011-01-04 | Boston Scientific Scimed, Inc. | Method of manufacturing a medical device having a porous coating thereon |
US20060088566A1 (en) | 2004-10-27 | 2006-04-27 | Scimed Life Systems, Inc.,A Corporation | Method of controlling drug release from a coated medical device through the use of nucleating agents |
US7958840B2 (en) * | 2004-10-27 | 2011-06-14 | Surmodics, Inc. | Method and apparatus for coating of substrates |
US8029563B2 (en) | 2004-11-29 | 2011-10-04 | Gore Enterprise Holdings, Inc. | Implantable devices with reduced needle puncture site leakage |
US20060122694A1 (en) | 2004-12-03 | 2006-06-08 | Stinson Jonathan S | Medical devices and methods of making the same |
US20060129215A1 (en) | 2004-12-09 | 2006-06-15 | Helmus Michael N | Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery |
US7632390B2 (en) | 2004-12-10 | 2009-12-15 | Ryszard Rokicki | Apparatus and method for enhancing electropolishing utilizing magnetic fields |
DE202004020318U1 (de) | 2004-12-10 | 2005-03-24 | Europ Fuel Cell Gmbh | Brennstoffzellenheizgerät |
US20080140172A1 (en) | 2004-12-13 | 2008-06-12 | Robert Hunt Carpenter | Multi-Wall Expandable Device Capable Of Drug Delivery Related Applications |
US20060129225A1 (en) | 2004-12-15 | 2006-06-15 | Kopia Gregory A | Device for the delivery of a cardioprotective agent to ischemic reperfused myocardium |
US7632307B2 (en) | 2004-12-16 | 2009-12-15 | Advanced Cardiovascular Systems, Inc. | Abluminal, multilayer coating constructs for drug-delivery stents |
US20080003431A1 (en) * | 2006-06-20 | 2008-01-03 | Thomas John Fellinger | Coated fibrous nodules and insulation product |
PT1674117T (pt) | 2004-12-24 | 2018-11-26 | Hexacath | Peça mecânica com deformabilidade melhorada |
US7432327B2 (en) | 2004-12-30 | 2008-10-07 | Sabic Innovative Plastics Ip B.V. | Transparent polymeric compositions comprising polysiloxane-polycarbonate copolymer, articles made therefrom and methods of making same |
US20060149363A1 (en) | 2005-01-06 | 2006-07-06 | Scimed Life Systems, Inc. | Optimally expanded, collagen sealed ePTFE graft with improved tissue ingrowth |
US7727273B2 (en) | 2005-01-13 | 2010-06-01 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
WO2006074550A1 (en) | 2005-01-14 | 2006-07-20 | National Research Council Of Canada | Implantable biomimetic prosthetic bone |
DE102005003188A1 (de) | 2005-01-20 | 2006-07-27 | Restate Patent Ag | Medizinisches Implantat aus einer amorphen oder nanokristallinen Legierung |
US8057543B2 (en) | 2005-01-28 | 2011-11-15 | Greatbatch Ltd. | Stent coating for eluting medication |
WO2006080381A1 (ja) | 2005-01-28 | 2006-08-03 | Terumo Kabushiki Kaisha | 血管内インプラント |
US20060177480A1 (en) | 2005-02-10 | 2006-08-10 | Hsing-Wen Sung | Drug-eluting biodegradable stent |
US20070003589A1 (en) | 2005-02-17 | 2007-01-04 | Irina Astafieva | Coatings for implantable medical devices containing attractants for endothelial cells |
US7699863B2 (en) | 2005-03-01 | 2010-04-20 | Tulip Medical Ltd. | Bioerodible self-deployable intragastric implants |
US20060200229A1 (en) | 2005-03-03 | 2006-09-07 | Robert Burgermeister | Geometry and material for use in high strength, high flexibility, controlled recoil drug eluting stents |
US7540995B2 (en) | 2005-03-03 | 2009-06-02 | Icon Medical Corp. | Process for forming an improved metal alloy stent |
US8323333B2 (en) | 2005-03-03 | 2012-12-04 | Icon Medical Corp. | Fragile structure protective coating |
US20060198869A1 (en) | 2005-03-03 | 2006-09-07 | Icon Medical Corp. | Bioabsorable medical devices |
WO2006110197A2 (en) * | 2005-03-03 | 2006-10-19 | Icon Medical Corp. | Polymer biodegradable medical device |
US20060200232A1 (en) | 2005-03-04 | 2006-09-07 | Phaneuf Matthew D | Nanofibrous materials as drug, protein, or genetic release vehicles |
US7727278B2 (en) | 2005-03-04 | 2010-06-01 | Rti Biologics, Inc. | Self fixing assembled bone-tendon-bone graft |
US20060199876A1 (en) | 2005-03-04 | 2006-09-07 | The University Of British Columbia | Bioceramic composite coatings and process for making same |
GB2424223C (en) * | 2005-03-07 | 2011-02-02 | Massachusetts Inst Technology | Biomaterial. |
US20060204445A1 (en) | 2005-03-11 | 2006-09-14 | Anthony Atala | Cell scaffold matrices with image contrast agents |
US7531503B2 (en) | 2005-03-11 | 2009-05-12 | Wake Forest University Health Sciences | Cell scaffold matrices with incorporated therapeutic agents |
DE102005013221A1 (de) | 2005-03-17 | 2006-09-21 | Biotronik Vi Patent Ag | System zur Behandlung ausgedehnter obliterierender Erkrankungen eines Gefäßes |
CN101142149A (zh) | 2005-03-18 | 2008-03-12 | 金文申有限公司 | 制备多孔烧结金属材料的方法 |
US9056157B2 (en) | 2005-03-24 | 2015-06-16 | Medtronic Vascular, Inc. | Hybrid biodegradable/non-biodegradable stent, delivery system and method of treating a vascular condition |
US20060229715A1 (en) | 2005-03-29 | 2006-10-12 | Sdgi Holdings, Inc. | Implants incorporating nanotubes and methods for producing the same |
US9125968B2 (en) | 2005-03-30 | 2015-09-08 | Boston Scientific Scimed, Inc. | Polymeric/ceramic composite materials for use in medical devices |
JP2008538089A (ja) | 2005-03-31 | 2008-10-09 | コナー・ミッドシステムズ・インコーポレイテッド | 医療装置の中に有益な物質を装填するための方法 |
US7641983B2 (en) | 2005-04-04 | 2010-01-05 | Boston Scientific Scimed, Inc. | Medical devices including composites |
CA2604419C (en) * | 2005-04-05 | 2015-03-24 | Elixir Medical Corporation | Degradable implantable medical devices |
US20060233941A1 (en) | 2005-04-15 | 2006-10-19 | Boston Scientific Scimed, Inc. | Method of coating a medical device utilizing an ion-based thin film deposition technique, a system for coating a medical device, and a medical device produced by the method |
EP1883372A2 (en) | 2005-04-26 | 2008-02-06 | Christodoulos Stefanadis | Method and devices for treatment of vulnerable (unstable) and/or stable atherosclerotic plaque by disrupting pathologic vasa vasorum of the atherosclerotic plaque |
US8734851B2 (en) | 2005-04-29 | 2014-05-27 | Wisconsin Alumni Research Foundation | Localized delivery of nucleic acid by polyelectrolyte assemblies |
US7637941B1 (en) | 2005-05-11 | 2009-12-29 | Advanced Cardiovascular Systems, Inc. | Endothelial cell binding coatings for rapid encapsulation of bioerodable stents |
DE102005024151A1 (de) | 2005-05-23 | 2006-11-30 | Thomas Nicola | Vorrichtung zur Peritonealdialyse |
US20060276875A1 (en) | 2005-05-27 | 2006-12-07 | Stinson Jonathan S | Medical devices |
WO2006133223A2 (en) | 2005-06-06 | 2006-12-14 | Innovational Holdings, Llc | Implantable medical device with openings for delivery of beneficial agents with combination release kinetics |
FI20055304L (fi) | 2005-06-13 | 2007-02-20 | Bioretec Oy | Bioabsorboituva implantti, jolla on muuttuva ominaisuus |
US8273117B2 (en) | 2005-06-22 | 2012-09-25 | Integran Technologies Inc. | Low texture, quasi-isotropic metallic stent |
ATE513568T1 (de) | 2005-06-30 | 2011-07-15 | Accord Biomaterials Inc | Stickstoffoxidbeschichtungen für medizinische vorrichtungen |
DE102005031868A1 (de) * | 2005-07-04 | 2007-01-18 | Biotronik Vi Patent Ag | Arzneimitteldepot zur parenteralen, insbesondere intravaskulären Arzneimittelfreisetzung |
US20070038176A1 (en) | 2005-07-05 | 2007-02-15 | Jan Weber | Medical devices with machined layers for controlled communications with underlying regions |
DE102005032604A1 (de) | 2005-07-13 | 2007-01-18 | Gfe Medizintechnik Gmbh | Resorbierbares, in den Körper einsetzbares medizinisches Element, insbesondere resorbierbares Implantat |
US20070123131A1 (en) * | 2005-07-25 | 2007-05-31 | Hien Nguyen | Low-density, non-woven structures and methods of making the same |
US8870940B2 (en) | 2005-07-25 | 2014-10-28 | Medtronic, Inc. | Endolumenal prosthesis |
US7778684B2 (en) | 2005-08-08 | 2010-08-17 | Boston Scientific Scimed, Inc. | MRI resonator system with stent implant |
US20070034615A1 (en) * | 2005-08-15 | 2007-02-15 | Klaus Kleine | Fabricating medical devices with an ytterbium tungstate laser |
US20070038290A1 (en) * | 2005-08-15 | 2007-02-15 | Bin Huang | Fiber reinforced composite stents |
US7597924B2 (en) * | 2005-08-18 | 2009-10-06 | Boston Scientific Scimed, Inc. | Surface modification of ePTFE and implants using the same |
US9248034B2 (en) | 2005-08-23 | 2016-02-02 | Advanced Cardiovascular Systems, Inc. | Controlled disintegrating implantable medical devices |
US20070045252A1 (en) * | 2005-08-23 | 2007-03-01 | Klaus Kleine | Laser induced plasma machining with a process gas |
US20070050009A1 (en) | 2005-08-30 | 2007-03-01 | Aiden Flanagan | Bioabsorbable stent |
US20070048350A1 (en) | 2005-08-31 | 2007-03-01 | Robert Falotico | Antithrombotic coating for drug eluting medical devices |
US20070065418A1 (en) | 2005-09-20 | 2007-03-22 | Franco Vallana | Method and device for cellular therapy |
US20070073385A1 (en) | 2005-09-20 | 2007-03-29 | Cook Incorporated | Eluting, implantable medical device |
US20070073390A1 (en) | 2005-09-23 | 2007-03-29 | Medlogics Device Corporation | Methods and devices for enhanced adhesion between metallic substrates and bioactive material-containing coatings |
US20070264199A1 (en) | 2005-09-26 | 2007-11-15 | Labhasetwar Vinod D | Magnetic nanoparticle composition and methods for using the same |
US20090043374A1 (en) | 2005-10-05 | 2009-02-12 | Kaneka Corporation | Stent to be Placed in the Living Body |
US20070141106A1 (en) | 2005-10-19 | 2007-06-21 | Bonutti Peter M | Drug eluting implant |
US7563277B2 (en) | 2005-10-24 | 2009-07-21 | Cook Incorporated | Removable covering for implantable frame projections |
US8369950B2 (en) * | 2005-10-28 | 2013-02-05 | Cardiac Pacemakers, Inc. | Implantable medical device with fractal antenna |
US9440003B2 (en) * | 2005-11-04 | 2016-09-13 | Boston Scientific Scimed, Inc. | Medical devices having particle-containing regions with diamond-like coatings |
US20070104753A1 (en) | 2005-11-04 | 2007-05-10 | Aiden Flanagan | Medical device with a coating comprising an active form and an inactive form of therapeutic agent(s) |
GB0522569D0 (en) | 2005-11-04 | 2005-12-14 | Univ Bath | Biocompatible drug delivery device |
US20070106347A1 (en) | 2005-11-09 | 2007-05-10 | Wun-Chen Lin | Portable medical and cosmetic photon emission adjustment device and method using the same |
EP1959025B1 (en) | 2005-11-16 | 2012-03-21 | National Institute for Materials Science | Magnesium-based biodegradable metal material |
US20070135908A1 (en) | 2005-12-08 | 2007-06-14 | Zhao Jonathon Z | Absorbable stent comprising coating for controlling degradation and maintaining pH neutrality |
US20070134288A1 (en) | 2005-12-13 | 2007-06-14 | Edward Parsonage | Anti-adhesion agents for drug coatings |
US8518100B2 (en) | 2005-12-19 | 2013-08-27 | Advanced Cardiovascular Systems, Inc. | Drug eluting stent for the treatment of dialysis graft stenoses |
US20070148251A1 (en) | 2005-12-22 | 2007-06-28 | Hossainy Syed F A | Nanoparticle releasing medical devices |
WO2007079363A2 (en) | 2005-12-30 | 2007-07-12 | C.R Bard Inc. | Stent with bio-resorbable connector and methods |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US20070160641A1 (en) | 2006-01-12 | 2007-07-12 | Eun-Hyun Jang | Coated medical devices and methods of making the same |
US20070173923A1 (en) | 2006-01-20 | 2007-07-26 | Savage Douglas R | Drug reservoir stent |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US20070184083A1 (en) | 2006-02-07 | 2007-08-09 | Medtronic Vascular, Inc. | Drug-Eluting Device for Treatment of Chronic Total Occlusions |
US20070190104A1 (en) | 2006-02-13 | 2007-08-16 | Kamath Kalpana R | Coating comprising an adhesive polymeric material for a medical device and method of preparing the same |
US20070191931A1 (en) | 2006-02-16 | 2007-08-16 | Jan Weber | Bioerodible endoprostheses and methods of making the same |
US9526814B2 (en) | 2006-02-16 | 2016-12-27 | Boston Scientific Scimed, Inc. | Medical balloons and methods of making the same |
ATE551966T1 (de) | 2006-02-28 | 2012-04-15 | Straumann Holding Ag | Zweiteiliges implantat mit hydroxylierter kontaktoberfläche für weichgewebe |
AU2007248387A1 (en) | 2006-03-03 | 2007-11-15 | C. R. Bard, Inc. | Antimicrobial coating |
US8585753B2 (en) | 2006-03-04 | 2013-11-19 | John James Scanlon | Fibrillated biodegradable prosthesis |
US8597341B2 (en) | 2006-03-06 | 2013-12-03 | David Elmaleh | Intravascular device with netting system |
EP1834606B1 (en) | 2006-03-16 | 2013-04-24 | CID S.p.A. | Stents |
EP1835042A1 (en) | 2006-03-18 | 2007-09-19 | Acrostak Corp. | Magnesium-based alloy with improved combination of mechanical and corrosion characteristics |
EP1997522B1 (en) | 2006-03-20 | 2015-05-13 | National Institute for Materials Science | Method of controlling degradation time of a biodegradable device |
US20070224244A1 (en) | 2006-03-22 | 2007-09-27 | Jan Weber | Corrosion resistant coatings for biodegradable metallic implants |
US20070225799A1 (en) | 2006-03-24 | 2007-09-27 | Medtronic Vascular, Inc. | Stent, intraluminal stent delivery system, and method of treating a vascular condition |
US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
DE102006015457A1 (de) | 2006-03-31 | 2007-10-04 | Biotronik Vi Patent Ag | Magnesiumlegierung und dazugehöriges Herstellungsverfahren |
CA2645357C (en) | 2006-04-12 | 2016-02-16 | Arterial Remodeling Technologies, S.A. | Methods of polymeric stent surface smoothing and resurfacing to reduce biologically active sites |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
US20070244541A1 (en) | 2006-04-18 | 2007-10-18 | Medtronic Vascular, Inc., A Delaware Corporation | Methods and Devices for Contributing to Improved Stent Graft Fixation |
US20070250155A1 (en) | 2006-04-24 | 2007-10-25 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable medical device |
US7955383B2 (en) | 2006-04-25 | 2011-06-07 | Medtronics Vascular, Inc. | Laminated implantable medical device having a metallic coating |
US9155646B2 (en) | 2006-04-27 | 2015-10-13 | Brs Holdings, Llc | Composite stent with bioremovable ceramic flakes |
US20080051335A1 (en) | 2006-05-02 | 2008-02-28 | Kleiner Lothar W | Methods, compositions and devices for treating lesioned sites using bioabsorbable carriers |
US20070264303A1 (en) | 2006-05-12 | 2007-11-15 | Liliana Atanasoska | Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent |
AU2007249680B2 (en) | 2006-05-15 | 2012-02-02 | Covidien Lp | Antimicrobial coatings |
WO2007136969A2 (en) | 2006-05-16 | 2007-11-29 | Medtronic Vascular, Inc. | Bioabsorbable magnesium-reinforced polymer stents |
JP5290962B2 (ja) | 2006-05-17 | 2013-09-18 | デビオテック ソシエテ アノニム | 異方性ナノ多孔質被膜 |
US20070270942A1 (en) | 2006-05-19 | 2007-11-22 | Medtronic Vascular, Inc. | Galvanic Corrosion Methods and Devices for Fixation of Stent Grafts |
US20070282432A1 (en) * | 2006-05-31 | 2007-12-06 | Stinson Jonathan S | Implantable medical endoprostheses |
US20070281073A1 (en) | 2006-06-01 | 2007-12-06 | Gale David C | Enhanced adhesion of drug delivery coatings on stents |
US20070281117A1 (en) | 2006-06-02 | 2007-12-06 | Xtent, Inc. | Use of plasma in formation of biodegradable stent coating |
CN101460201A (zh) | 2006-06-05 | 2009-06-17 | 防菌公司 | 聚合物基质、其用途和制造该聚合物基质的方法 |
GB0612028D0 (en) | 2006-06-16 | 2006-07-26 | Imp Innovations Ltd | Bioactive glass |
DE102006029247A1 (de) | 2006-06-26 | 2007-12-27 | Biotronik Vi Patent Ag | Implantat mit einer Cholesterol- oder Cholesterolester-haltigen Beschichtung |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
CA2655793A1 (en) | 2006-06-29 | 2008-01-03 | Boston Scientific Limited | Medical devices with selective coating |
DE102006030588A1 (de) | 2006-07-03 | 2008-01-10 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Flüssigkeitsstrahlgeführtes Ätzverfahren zum Materialabtrag an Festkörpern sowie dessen Verwendung |
US9265866B2 (en) * | 2006-08-01 | 2016-02-23 | Abbott Cardiovascular Systems Inc. | Composite polymeric and metallic stent with radiopacity |
WO2008016713A2 (en) * | 2006-08-02 | 2008-02-07 | Inframat Corporation | Lumen-supporting devices and methods of making and using |
JP2009545407A (ja) | 2006-08-02 | 2009-12-24 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 三次元分解制御を備えたエンドプロテーゼ |
US20080069854A1 (en) * | 2006-08-02 | 2008-03-20 | Inframat Corporation | Medical devices and methods of making and using |
US20080033522A1 (en) * | 2006-08-03 | 2008-02-07 | Med Institute, Inc. | Implantable Medical Device with Particulate Coating |
DE102006038233A1 (de) | 2006-08-07 | 2008-02-14 | Biotronik Vi Patent Ag | Markerkomposit für medizinische Implantate |
DE102006038236A1 (de) | 2006-08-07 | 2008-02-14 | Biotronik Vi Patent Ag | Biodegradierbarer Stent mit einer aktiven Beschichtung |
DE102006038235A1 (de) * | 2006-08-07 | 2008-02-14 | Biotronik Vi Patent Ag | Verbesserung der Stabilität biodegradierbarer metallischer Stents, Verfahren und Verwendung |
DE102006038241A1 (de) | 2006-08-07 | 2008-02-14 | Biotronik Vi Patent Ag | Stent mit einer genisteinhaltigen Beschichtung oder Kavitätenfüllung |
DE102006038237A1 (de) | 2006-08-07 | 2008-02-14 | Biotronik Vi Patent Ag | Markerlegierung |
DE102006038232A1 (de) | 2006-08-07 | 2008-02-14 | Biotronik Vi Patent Ag | Endoprothese und Verfahren zur Herstellung einer solchen |
DE102006038238A1 (de) | 2006-08-07 | 2008-02-14 | Biotronik Vi Patent Ag | Röntgenmarker für medizinische Implantate aus einem biokorrodierbaren metallischen Werkstoff |
DE102006038231A1 (de) | 2006-08-07 | 2008-02-14 | Biotronik Vi Patent Ag | Implantat aus einem biokorrodierbaren metallischen Werkstoff mit einer Beschichtung aus einer Organosiliziumverbindung |
US20080058921A1 (en) | 2006-08-09 | 2008-03-06 | Lindquist Jeffrey S | Improved adhesion of a polymeric coating of a drug eluting stent |
DE102006039346A1 (de) | 2006-08-22 | 2008-03-13 | Biotronik Vi Patent Ag | Biokorrodierbares metallisches Implantat mit einer Beschichtung oder Kavitätenfüllung aus einem PEG/PLGA-Copolymer |
US20080050413A1 (en) | 2006-08-23 | 2008-02-28 | Ronald Adrianus Maria Horvers | Medical stent provided with a combination of melatonin and paclitaxel |
US20080051881A1 (en) | 2006-08-24 | 2008-02-28 | Feng James Q | Medical devices comprising porous layers for the release of therapeutic agents |
DE102006042313A1 (de) | 2006-09-06 | 2008-03-27 | Biotronik Vi Patent Ag | Biokorrodierbares metallisches Implantat mit einer Beschichtung oder Kavitätenfüllung aus Gelatine |
CA2662473A1 (en) | 2006-09-06 | 2008-03-13 | Boston Scientific Limited | Medical devices having nanostructured coating for macromolecule delivery |
JP2010503469A (ja) | 2006-09-14 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 薬物溶出性皮膜を有する医療デバイス |
WO2008034066A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making the same |
DE602007011114D1 (de) | 2006-09-15 | 2011-01-20 | Boston Scient Scimed Inc | Biologisch erodierbare endoprothese mit biostabilen anorganischen schichten |
WO2008034013A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices and methods of making the same |
EP2066363A2 (en) | 2006-09-15 | 2009-06-10 | Boston Scientific Limited | Endoprosthesis containing magnetic induction particles |
WO2008034047A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Endoprosthesis with adjustable surface features |
EP2068780A2 (en) | 2006-09-15 | 2009-06-17 | Boston Scientific Limited | Medical devices |
JP2010503489A (ja) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 生体内分解性内部人工器官およびその製造方法 |
WO2008034030A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Magnetized bioerodible endoprosthesis |
WO2008036554A2 (en) | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Endoprostheses |
US20080071349A1 (en) | 2006-09-18 | 2008-03-20 | Boston Scientific Scimed, Inc. | Medical Devices |
WO2008036457A2 (en) | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Controlling biodegradation of a medical instrument |
WO2008036548A2 (en) | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Endoprostheses |
US20080069858A1 (en) * | 2006-09-20 | 2008-03-20 | Boston Scientific Scimed, Inc. | Medical devices having biodegradable polymeric regions with overlying hard, thin layers |
CN102512711A (zh) | 2006-09-22 | 2012-06-27 | 友和安股份公司 | 由生物可降解金属构成的植入物及其制造方法 |
US7557167B2 (en) | 2006-09-28 | 2009-07-07 | Gore Enterprise Holdings, Inc. | Polyester compositions, methods of manufacturing said compositions, and articles made therefrom |
US8394488B2 (en) * | 2006-10-06 | 2013-03-12 | Cordis Corporation | Bioabsorbable device having composite structure for accelerating degradation |
DE102006048819A1 (de) | 2006-10-10 | 2008-04-17 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Vorrichtung mit einem Grundkörper |
US20080090097A1 (en) | 2006-10-11 | 2008-04-17 | The Penn State Research Foundation | Chemically and physically tailored structured thin film assemblies for corrosion prevention or promotion |
US20080097577A1 (en) * | 2006-10-20 | 2008-04-24 | Boston Scientific Scimed, Inc. | Medical device hydrogen surface treatment by electrochemical reduction |
CA2668408A1 (en) | 2006-11-03 | 2008-05-15 | Boston Scientific Limited | Ion bombardment of medical devices |
US20080243113A1 (en) | 2006-11-08 | 2008-10-02 | Shastri V Prasad | Modification of stent surfaces to impart functionality |
US7981150B2 (en) | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
US20080294236A1 (en) | 2007-05-23 | 2008-11-27 | Boston Scientific Scimed, Inc. | Endoprosthesis with Select Ceramic and Polymer Coatings |
US7919137B2 (en) * | 2006-11-13 | 2011-04-05 | Boston Scientific Scimed, Inc. | Medical devices having adherent polymeric layers with depth-dependent properties |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US20080213377A1 (en) | 2006-12-08 | 2008-09-04 | Bhatia Sangeeta N | Delivery of Nanoparticles and/or Agents to Cells |
US20080148002A1 (en) | 2006-12-13 | 2008-06-19 | Fleming Matthew D | Method and Apparatus for Allocating A Dynamic Data Structure |
US7651527B2 (en) | 2006-12-15 | 2010-01-26 | Medtronic Vascular, Inc. | Bioresorbable stent |
JP2010512815A (ja) | 2006-12-15 | 2010-04-30 | コロプラスト アクティーゼルスカブ | ポリ(エチレンオキシド)及び光開始剤含有骨格から調製されたコーティング |
DE102006060501A1 (de) | 2006-12-19 | 2008-06-26 | Biotronik Vi Patent Ag | Verfahren zur Herstellung einer korrosionshemmenden Beschichtung auf einem Implantat aus einer biokorrodierbaren Magnesiumlegierung sowie nach dem Verfahren hergestelltes Implantat |
EP2125066A2 (en) | 2006-12-20 | 2009-12-02 | Boston Scientific Limited | Stent with a coating for delivering a therapeutic agent |
US7939095B2 (en) | 2006-12-21 | 2011-05-10 | Cordis Corporation | Crosslinked silane coating for medical devices |
EP2114480B1 (en) | 2006-12-28 | 2016-01-06 | Boston Scientific Limited | Medical devices and methods of making the same |
ES2506144T3 (es) | 2006-12-28 | 2014-10-13 | Boston Scientific Limited | Endoprótesis bioerosionables y procedimiento de fabricación de las mismas |
US20080171929A1 (en) | 2007-01-11 | 2008-07-17 | Katims Jefferson J | Method for standardizing spacing between electrodes, and medical tape electrodes |
US20080175885A1 (en) | 2007-01-19 | 2008-07-24 | Cinvention Ag | Porous, degradable implant made by powder molding |
AU2008206954A1 (en) | 2007-01-19 | 2008-07-24 | Cinvention Ag | Partially bioabsorbable implant |
DE102007003708A1 (de) | 2007-01-25 | 2008-07-31 | Biotronik Vi Patent Ag | Mit Biomolekülen beschichtete Stents sowie Verfahren zu deren Herstellung |
EP2125064B1 (en) | 2007-01-26 | 2017-04-26 | Boston Scientific Limited | Implantable medical endoprostheses |
DE102007004589A1 (de) | 2007-01-30 | 2008-07-31 | Orlowski, Michael, Dr. | Bioresorbierbarer Metallstent mit kontrollierter Resorption |
MX2009008064A (es) | 2007-01-30 | 2009-08-07 | Hemoteq Ag | Soporte vascular biodegradable. |
EP2120807A2 (en) | 2007-02-13 | 2009-11-25 | Cinvention Ag | Degradable reservoir implants |
WO2008098922A2 (en) * | 2007-02-13 | 2008-08-21 | Cinvention Ag | Biodegradable porous stent |
US7758635B2 (en) | 2007-02-13 | 2010-07-20 | Boston Scientific Scimed, Inc. | Medical device including cylindrical micelles |
EP2111482A2 (en) | 2007-02-13 | 2009-10-28 | Cinvention Ag | Medical devices with extended or multiple reservoirs |
US8273402B2 (en) | 2007-02-26 | 2012-09-25 | Medtronic Vascular, Inc. | Drug coated stent with magnesium topcoat |
US20080208352A1 (en) | 2007-02-27 | 2008-08-28 | Medtronic Vascular, Inc. | Stent Having Controlled Porosity for Improved Ductility |
US20080208308A1 (en) | 2007-02-27 | 2008-08-28 | Medtronic Vascular, Inc. | High Temperature Oxidation-Reduction Process to Form Porous Structures on a Medical Implant |
US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
CN101636130B (zh) * | 2007-03-23 | 2012-04-25 | 因瓦泰克技术中心有限公司 | 腔内假体 |
US20080243240A1 (en) | 2007-03-26 | 2008-10-02 | Medtronic Vascular, Inc. | Biodegradable Metal Barrier Layer for a Drug-Eluting Stent |
US20080243234A1 (en) | 2007-03-27 | 2008-10-02 | Medtronic Vascular, Inc. | Magnesium Alloy Stent |
DE102007015670A1 (de) | 2007-03-31 | 2008-10-02 | Biotronik Vi Patent Ag | Stent mit radial expandierbarem Grundkörper |
US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
US20080249600A1 (en) | 2007-04-06 | 2008-10-09 | Boston Scientific Scimed, Inc. | Stents with drug reservoir layer and methods of making and using the same |
US8703168B2 (en) | 2007-04-25 | 2014-04-22 | Boston Scientific Scimed, Inc. | Medical devices for releasing therapeutic agent and methods of making the same |
DE102007019703A1 (de) | 2007-04-26 | 2008-10-30 | Biotronik Vi Patent Ag | Stent |
US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
US7888719B2 (en) | 2007-05-23 | 2011-02-15 | Taiwan Semiconductor Manufacturing Co., Ltd. | Semiconductor memory structures |
PL2000551T3 (pl) | 2007-05-28 | 2011-02-28 | Acrostak Corp Bvi | Stopy oparte na magnezie |
US20080306584A1 (en) | 2007-06-05 | 2008-12-11 | Pamela Kramer-Brown | Implantable medical devices for local and regional treatment |
US7632305B2 (en) | 2007-07-06 | 2009-12-15 | Boston Scientific Scimed, Inc. | Biodegradable connectors |
US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
DE102007032686A1 (de) | 2007-07-13 | 2009-01-15 | Biotronik Vi Patent Ag | Stent mit einer Beschichtung |
US8205317B2 (en) | 2007-07-16 | 2012-06-26 | Medtronic Vascular, Inc. | Method of manufacturing a controlled porosity stent |
WO2009012353A2 (en) | 2007-07-19 | 2009-01-22 | Boston Scientific Limited | Endoprosthesis having a non-fouling surface |
DE102007034019A1 (de) | 2007-07-20 | 2009-01-22 | Biotronik Vi Patent Ag | Stent mit einer Beschichtung oder Füllung einer Kavität |
DE102007034041A1 (de) | 2007-07-20 | 2009-01-22 | Biotronik Vi Patent Ag | Medikamentendepots für medizinische Implantate |
US20090035351A1 (en) | 2007-07-20 | 2009-02-05 | Medtronic Vascular, Inc. | Bioabsorbable Hypotubes for Intravascular Drug Delivery |
US20090024209A1 (en) | 2007-07-20 | 2009-01-22 | Medtronic Vascular, Inc. | Hypotubes for Intravascular Drug Delivery |
US20090028785A1 (en) | 2007-07-23 | 2009-01-29 | Boston Scientific Scimed, Inc. | Medical devices with coatings for delivery of a therapeutic agent |
US20090157172A1 (en) | 2007-07-24 | 2009-06-18 | Boston Scientific Scrimed, Inc. | Stents with polymer-free coatings for delivering a therapeutic agent |
DE102007034364A1 (de) | 2007-07-24 | 2009-01-29 | Biotronik Vi Patent Ag | Degradierbarer Metallstent mit wirkstoffhaltiger Beschichtung |
DE102007034363A1 (de) | 2007-07-24 | 2009-01-29 | Biotronik Vi Patent Ag | Endoprothese |
US20090030504A1 (en) | 2007-07-27 | 2009-01-29 | Boston Scientific Scimed, Inc. | Medical devices comprising porous inorganic fibers for the release of therapeutic agents |
US20090030500A1 (en) | 2007-07-27 | 2009-01-29 | Jan Weber | Iron Ion Releasing Endoprostheses |
US20090043380A1 (en) | 2007-08-09 | 2009-02-12 | Specialized Vascular Technologies, Inc. | Coatings for promoting endothelization of medical devices |
US20090043330A1 (en) | 2007-08-09 | 2009-02-12 | Specialized Vascular Technologies, Inc. | Embolic protection devices and methods |
DE102007038799A1 (de) | 2007-08-17 | 2009-02-19 | Biotronik Vi Patent Ag | Implantat aus einer biokorrodierbaren Magnesiumlegierung und mit einer Beschichtung aus einem biokorrodierbaren Polyphosphazen |
DE102007042451A1 (de) | 2007-09-06 | 2009-03-12 | Biotronik Vi Patent Ag | Stent mit einem Grundkörper aus einer biokorrodierbaren Legierung |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
DE102007043883A1 (de) | 2007-09-14 | 2009-03-26 | Biotronik Vi Patent Ag | Stent mit einer Beschichtung |
US9173890B2 (en) | 2007-09-20 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
JP2009082353A (ja) | 2007-09-28 | 2009-04-23 | Terumo Corp | 生体内留置用ステントおよび生体器官拡張器具 |
US8998978B2 (en) | 2007-09-28 | 2015-04-07 | Abbott Cardiovascular Systems Inc. | Stent formed from bioerodible metal-bioceramic composite |
US20090093871A1 (en) | 2007-10-08 | 2009-04-09 | Medtronic Vascular, Inc. | Medical Implant With Internal Drug Delivery System |
US20090287302A1 (en) | 2008-05-16 | 2009-11-19 | Chameleon Scientific Corporation | Polymer coated spinulose metal surfaces |
US20090118823A1 (en) | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with porous reservoir |
US20090118818A1 (en) | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with coating |
US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20090118821A1 (en) | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with porous reservoir and non-polymer diffusion layer |
US20090118812A1 (en) | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20090118813A1 (en) | 2007-11-02 | 2009-05-07 | Torsten Scheuermann | Nano-patterned implant surfaces |
US20090118815A1 (en) | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Stent |
US20090118809A1 (en) | 2007-11-02 | 2009-05-07 | Torsten Scheuermann | Endoprosthesis with porous reservoir and non-polymer diffusion layer |
EP2214738B1 (en) | 2007-11-02 | 2012-05-02 | Boston Scientific Limited | Degradable endoprosthesis |
US20090143855A1 (en) | 2007-11-29 | 2009-06-04 | Boston Scientific Scimed, Inc. | Medical Device Including Drug-Loaded Fibers |
EP2067494A1 (en) | 2007-12-04 | 2009-06-10 | Charité-Universitätsmedizin Berlin | Sheet or tubular structure consisting of elastic biocompatible material and its use |
WO2009079389A2 (en) | 2007-12-14 | 2009-06-25 | Boston Scientific Limited | Drug-eluting endoprosthesis |
DE102007061647A1 (de) | 2007-12-20 | 2009-07-02 | Biotronik Vi Patent Ag | Implantat mit einem Grundkörper aus einer biokorrodierbaren Legierung |
US8317857B2 (en) | 2008-01-10 | 2012-11-27 | Telesis Research, Llc | Biodegradable self-expanding prosthesis |
DE102008006455A1 (de) | 2008-01-29 | 2009-07-30 | Biotronik Vi Patent Ag | Implantat mit einem Grundkörper aus einer biokorrodierbaren Legierung und einer korrosionshemmenden Beschichtung |
JP2009178293A (ja) | 2008-01-30 | 2009-08-13 | Terumo Corp | 医療用インプラント |
DE102008006654A1 (de) | 2008-01-30 | 2009-08-06 | Biotronik Vi Patent Ag | Implantat mit einem Grundkörper aus einer biokorrodierbaren Legierung |
US20090196899A1 (en) | 2008-01-31 | 2009-08-06 | Medtronic Vascular, Inc. | Controlled Alloy Stent |
DE102008002601A1 (de) | 2008-02-05 | 2009-08-06 | Biotronik Vi Patent Ag | Implantat mit einem Grundkörper aus einer biokorrodierbaren Eisenlegierung |
US20090204203A1 (en) | 2008-02-07 | 2009-08-13 | Medtronic Vascular, Inc. | Bioabsorbable Stent Having a Radiopaque Marker |
WO2009102787A2 (en) | 2008-02-12 | 2009-08-20 | Boston Scientific Scimed, Inc. | Medical implants with polysaccharide drug eluting coatings |
EP2254605A4 (en) | 2008-02-22 | 2012-06-20 | Celonova Biosciences Inc | MULTIFUNCTIONAL MATRICES FOR DRESSINGS AND ASSOCIATED METHODS |
US20100042206A1 (en) | 2008-03-04 | 2010-02-18 | Icon Medical Corp. | Bioabsorbable coatings for medical devices |
US20090228037A1 (en) | 2008-03-07 | 2009-09-10 | Medtronic Vascular, Inc | Vascular Closure Implant |
US20090240323A1 (en) | 2008-03-20 | 2009-09-24 | Medtronic Vascular, Inc. | Controlled Degradation of Magnesium Stents |
WO2009126766A2 (en) | 2008-04-10 | 2009-10-15 | Boston Scientific Scimed, Inc. | Medical devices with an interlocking coating and methods of making the same |
DE102008020415A1 (de) | 2008-04-24 | 2009-10-29 | Biotronik Vi Patent Ag | Biodegradierbare metallische Stents mit Wachsschicht |
DE102008021894A1 (de) | 2008-05-02 | 2009-11-05 | Biotronik Vi Patent Ag | Implantat umfassend eine Oberfläche mit verringerter Thrombogenität |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US20090287301A1 (en) | 2008-05-16 | 2009-11-19 | Boston Scientific, Scimed Inc. | Coating for medical implants |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
AU2009257304A1 (en) | 2008-06-13 | 2009-12-17 | Pivot Medical, Inc. | Methods and apparatus for joint distraction |
DE102008002471A1 (de) | 2008-06-17 | 2009-12-24 | Biotronik Vi Patent Ag | Stent mit einer Beschichtung oder einem Grundkörper, der ein Lithiumsalz enthält, und Verwendung von Lithiumsalzen zur Restenoseprophylaxe |
WO2009158325A2 (en) | 2008-06-25 | 2009-12-30 | Boston Scientific Scimed, Inc. | Medical devices having surface coatings |
EP2307069A2 (en) | 2008-06-25 | 2011-04-13 | Boston Scientific Scimed, Inc. | Medical devices for delivery of therapeutic agent in conjunction with galvanic corrosion |
DE102008040253A1 (de) | 2008-07-08 | 2010-01-14 | Biotronik Vi Patent Ag | Implantatsystem mit einem Funktionsimplantat aus abbaubarem Metallmaterial |
DE102008040356A1 (de) | 2008-07-11 | 2010-01-14 | Biotronik Vi Patent Ag | Stent mit biodegradierbaren Stentstreben und Wirkstoffdepots |
US8361139B2 (en) | 2008-07-16 | 2013-01-29 | Boston Scientific Scimed, Inc. | Medical devices having metal coatings for controlled drug release |
US9220818B2 (en) | 2008-07-23 | 2015-12-29 | Boston Scientific Scimed, Inc. | Medical devices having inorganic barrier coatings |
DE102008040786A1 (de) | 2008-07-28 | 2010-02-04 | Biotronik Vi Patent Ag | Biokorrodierbares Implantat mit einer Beschichtung enthaltend eine wirkstofftragende Polymermatrix |
DE102008040787A1 (de) | 2008-07-28 | 2010-02-04 | Biotronik Vi Patent Ag | Biokorrodierbares Implantat mit einer Beschichtung enthaltend ein Hydrogel |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
WO2010019645A2 (en) | 2008-08-14 | 2010-02-18 | Boston Scientific Scimed, Inc. | Medical devices having electrodeposited conductive polymer coatings |
DE102008038367A1 (de) | 2008-08-19 | 2010-02-25 | Biotronik Vi Patent Ag | Stent und Verfahren und Vorrichtung zur Herstellung des Stents |
DE102008038368A1 (de) | 2008-08-19 | 2010-02-25 | Biotronik Vi Patent Ag | Verwendung von organischen Gold-Komplexen als bioaktive und radioopaque Stentbeschichtung für permanente und degradierbare vaskuläre Implantate |
US8642063B2 (en) | 2008-08-22 | 2014-02-04 | Cook Medical Technologies Llc | Implantable medical device coatings with biodegradable elastomer and releasable taxane agent |
CN102196826A (zh) | 2008-08-27 | 2011-09-21 | 波士顿科学医学有限公司 | 用于治疗剂递送具有无机涂层的医疗装置 |
US8337878B2 (en) | 2008-08-27 | 2012-12-25 | Boston Scientific Scimed, Inc. | Medical devices having coatings for therapeutic agent delivery |
US20100057188A1 (en) | 2008-08-28 | 2010-03-04 | Boston Scientific Scimed, Inc. | Endoprostheses with porous regions and non-polymeric coating |
US9119906B2 (en) | 2008-09-24 | 2015-09-01 | Integran Technologies, Inc. | In-vivo biodegradable medical implant |
DE602008006079D1 (de) | 2008-09-30 | 2011-05-19 | Biotronik Vi Patent Ag | Implantat aus einer biologisch abbaubaren Magnesiumlegierung |
DE102008042578A1 (de) | 2008-10-02 | 2010-04-08 | Biotronik Vi Patent Ag | Implantat mit einem Grundkörper aus einer biokorrodierbaren Manganlegierung |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
DE102008042603A1 (de) | 2008-10-06 | 2010-04-08 | Biotronik Vi Patent Ag | Implantat sowie Verfahren zur Herstellung einer degradationshemmenden Schicht auf einer Körperoberfläche eines Implantats |
EP2179752B1 (de) | 2008-10-06 | 2014-08-13 | Biotronik VI Patent AG | Implantat sowie Verfahren zur Herstellung desselben |
DE102009002709A1 (de) | 2008-10-06 | 2010-04-08 | Biotronik Vi Patent Ag | Implantat und Verfahren zur Herstellung desselben |
US20100092535A1 (en) | 2008-10-10 | 2010-04-15 | Medtronic Vascular, Inc. | Nanoporous Drug Delivery System |
DE102008043277A1 (de) | 2008-10-29 | 2010-05-06 | Biotronik Vi Patent Ag | Implantat aus einer biokorrodierbaren Eisen- oder Magnesiumlegierung |
DE102008043642A1 (de) | 2008-11-11 | 2010-05-12 | Biotronik Vi Patent Ag | Endoprothese |
DE102008043724A1 (de) | 2008-11-13 | 2010-05-20 | Biotronik Vi Patent Ag | Erhöhung der Effizienz pharmazeutische Wirkstoffe-freisetzender Medizinprodukte durch Kombination mit einem Inhibitor des Transportproteins P-Glycoprotein |
US20100125325A1 (en) | 2008-11-20 | 2010-05-20 | Medtronic Vascular, Inc. | Stent With Cathodic Protection and Stent Delivery System |
DE102008043970A1 (de) | 2008-11-21 | 2010-05-27 | Biotronik Vi Patent Ag | Verfahren zur Herstellung einer korrosionshemmenden Beschichtung auf einem Implantat aus einer biokorrodierbaren Magnesiumlegierung sowie nach dem Verfahren hergestelltes Implantat |
US9283304B2 (en) | 2008-11-25 | 2016-03-15 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Absorbable stent having a coating for controlling degradation of the stent and maintaining pH neutrality |
US20100217370A1 (en) | 2009-02-20 | 2010-08-26 | Boston Scientific Scimed, Inc. | Bioerodible Endoprosthesis |
-
2008
- 2008-06-10 US US12/136,537 patent/US8236046B2/en not_active Expired - Fee Related
-
2009
- 2009-06-09 EP EP09763443A patent/EP2303348B1/en not_active Not-in-force
- 2009-06-09 CA CA2727568A patent/CA2727568A1/en not_active Abandoned
- 2009-06-09 CN CN200980122076.9A patent/CN102056635B/zh not_active Expired - Fee Related
- 2009-06-09 WO PCT/US2009/046750 patent/WO2009152153A2/en active Application Filing
- 2009-06-09 JP JP2011513633A patent/JP5567010B2/ja not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7261734B2 (en) * | 2002-04-23 | 2007-08-28 | Boston Scientific Scimed, Inc. | Resorption-controllable medical implants |
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EP2303348A2 (en) | 2011-04-06 |
CN102056635A (zh) | 2011-05-11 |
US20090306765A1 (en) | 2009-12-10 |
JP2011522677A (ja) | 2011-08-04 |
JP5567010B2 (ja) | 2014-08-06 |
WO2009152153A3 (en) | 2010-09-30 |
CA2727568A1 (en) | 2009-12-17 |
WO2009152153A2 (en) | 2009-12-17 |
US8236046B2 (en) | 2012-08-07 |
EP2303348B1 (en) | 2013-03-20 |
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