CN102218156A - Preparation method of alginate functional hydrocolloid medical dressing - Google Patents

Abstract

The invention relates to a preparation method of an alginate functional hydrocolloid medical dressing, which comprises the following steps: 1. heating 45-80 parts by weight of polyisobutylene medical hot-melt adhesive in a mixer to 130-150 DEG C until the hot-melt adhesive is dissolved, thereby forming a component A; 2. mixing 20-40 parts by weight of sodium carboxymethyl cellulose, 1-7 parts by weight of pectin, 8-15 parts by weight of calcium alginate and/or 8-15 parts by weight sodium alginate at ordinary temperature to obtain solid powder of which the particle size is 150-300 meshes, which is a component B; 3. slowly adding the ready-mixed component B into the component A, mixing in vacuum at constant temperature of 120-130 DEG C for 60-90 minutes, and carrying out injection molding onto release paper or a PU (polyurethane) film; and 4. aging the formed hydrocolloid at 30-65 DEG C for 72 hours, and carrying out compression molding to obtain the dressing which is suitable for wounds in various shapes. The dressing provided by the invention is suitable for wounds in various shapes, and is especially suitable for the wound where the dressing is difficult to fix.

Description

The preparation method of alginate activated water colloid medical dressing

Technical field

The present invention is a kind of hydrocolloid medical dressing and preparation method, particularly a kind of preparation method of alginate activated water colloid medical dressing.

Background technology

The hydrocolloid medical dressing be a kind ofly have waterproof, anti, preserve moisture, the new pattern compress of advantage such as insulation.Used material and the effect difference of hydrocolloid medical dressing at present is very big, and the wound that bearing hydrocolloid dressing is nursed also is in different poses and with different expressions, at different wounds, needs safety good and have a hydrocolloid medical dressing of difference in functionality.

The patent of invention that relates to bearing hydrocolloid dressing from domestic patent retrieval to binomial, its publication number is respectively CN101569758A and CN101559236.The used main material of this binomial patent of invention bearing hydrocolloid dressing is adjuvants such as styrene, aliphatic petroleum resin, rubber, gelatin and sodium carboxymethyl cellulose, carboxymethyl chitosan, calcium alginate fibre, solid fine silver particle, preparation method complexity, safety remain to be proved.

Summary of the invention

The objective of the invention is in order to overcome the insecure defective of the complicated safety of existing bearing hydrocolloid dressing preparation method, invent a kind of polyisobutylene that adopts and make the preparation method that base material, alginate are made the alginate activated water colloid medical dressing of adjuvant.

The objective of the invention is to realize by following technical scheme:

The preparation method of described alginate activated water colloid medical dressing may further comprise the steps:

Step 1 is got 130 ℃ of-150 ℃ of dissolvings of heating of polyisobutylene medical hot melt glue 45-80 weight portion in blender, form the A component;

Step 2 with sodium carboxymethyl cellulose 10-40 weight portion, pectin 1-7 weight portion and calcium alginate 8-15 weight portion and/or sodium alginate 8-15 weight portion, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;

Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;

Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and become product for being fit to the shape of various wounds then.

Good effect of the present invention is as follows: according to the alginate hydrocolloid medical dressing of this method preparation, be applicable to the wound of different shape, be particularly suitable for the wound of difficult fixed position; The dressing of the medical alginate colloid of the present invention, be composited by high molecular hydrophobic polyisobutylene adhesive and hydrophilic sodium carboxymethyl cellulose and alginate and pectin, the double effects that it has bonding skin and absorbs wound fluid, absorb transudate from wound surface, constitute moistening environment, be of value to the growth of cambium, promote wound healing.The medical alginate bearing hydrocolloid dressing of the present invention also has the function of the growth that can promote epidermal tissue, and the bearing hydrocolloid dressing of alginate calcium ion under humoral effect is free, and calcium ion can promote the growth of epidermal tissue.

The polyisobutylene chemical property is stable, and is nontoxic, is applicable to medicine of different nature, do not change the character and the therapeutical effect of medicine, and polyisobutylene is weather-proof good, softness, and good springiness, hot strength is big, moulding processability is stable, and adhesion can be regulated, and is the desirable base material of bearing hydrocolloid dressing.Be added with the bearing hydrocolloid dressing of functional adjuvant sodium carboxymethyl cellulose, pectin and alginate, be applicable to the common wound of nursing.Different wounds uses this bearing hydrocolloid dressing at different healing stages, can promote the healing of wound, reduces patient's misery.

The specific embodiment

One of embodiment:

Step 1 is got 48 kilograms in polyisobutylene medical hot melt glue, and heating up in de-airing mixer is heated to 130 ℃ of-150 ℃ of dissolvings, forms the A component;

Step 2 with 10 kilograms of 15 kilograms of sodium carboxymethyl cellulose, 3 kilograms of pectin and calcium alginates, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;

Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, then injection mo(u)lding on release paper or PU film,

Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and formed product for being fit to the shape of various wounds then.

Two of embodiment:

Step 1 is got 80 kilograms in polyisobutylene medical hot melt glue, and heating up in de-airing mixer is heated to 130 ℃ of-150 ℃ of dissolvings, forms the A component;

Step 2 with 12 kilograms of 30 kilograms of sodium carboxymethyl cellulose, 2 kilograms of pectin and sodium alginates, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;

Step 3 slowly adds the A component with the B component that stirs, and vacuum constant temperature stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;

Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and formed product for being fit to the shape of various wounds then.

Three of embodiment:

Step 1 is got 70 kilograms in polyisobutylene medical hot melt glue, and heating up in de-airing mixer is heated to 130 ℃ of-150 ℃ of dissolvings, forms the A component;

Step 2, with 8 kilograms of 10 kilograms of sodium carboxymethyl cellulose, 4 kilograms of pectin and calcium alginates, 8 kilograms of sodium alginates are mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;

Step 3 slowly adds the A component with the B component that stirs, and vacuum constant temperature stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;

Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and formed product for being fit to the shape of various wounds then.

The foregoing description is used for the present invention that explains, rather than limits the invention, and in the protection domain of spirit of the present invention and claim, any modification and change to the present invention makes all fall into protection scope of the present invention.

Claims (1)

1. the preparation method of an alginate activated water colloid medical dressing, it is characterized in that: the preparation method of described alginate activated water colloid medical dressing may further comprise the steps:

Step 1 is got 130 ℃ of-150 ℃ of dissolvings of heating of polyisobutylene medical hot melt glue 45-80 weight portion in blender, form the A component;

Step 2 with sodium carboxymethyl cellulose 20-40 weight portion, pectin 1-7 weight portion and calcium alginate 8-15 weight portion and/or sodium alginate 8-15 weight portion, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;

Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;

Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and become product for being fit to the shape of various wounds then.