CN102232875A - Threaded biomedical implant structure and selective surface treatment method thereof - Google Patents
Threaded biomedical implant structure and selective surface treatment method thereof Download PDFInfo
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- CN102232875A CN102232875A CN201010166884XA CN201010166884A CN102232875A CN 102232875 A CN102232875 A CN 102232875A CN 201010166884X A CN201010166884X A CN 201010166884XA CN 201010166884 A CN201010166884 A CN 201010166884A CN 102232875 A CN102232875 A CN 102232875A
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Abstract
The invention discloses a threaded biomedical implant structure and a selective surface treatment method thereof. The surface of the biomedical implant structure has threads and a plurality of nano holes, wherein the holes are only distributed in an area between threads. The method comprises: providing a biomedical implant structure with threads on the surface; cleaning the surface of the biomedical implant structure; performing heat treatment and anodic treatment on the biomedical implant structure; and forming the plurality of nano holes on the surface of the biomedical implant structure. The nano holes are selectively grown between the threads, and electrolyte used in the anodic treatment contains fluorinions. In the biomedical implant structure and the selective surface treatment method thereof, the nano holes are selectively grown only in the area between the threads on the surface of the implant structure, so when the implant structure is stressed, the parts where the threads with relative low strength are formed are insusceptible to deformation or collapse due to stress; and after being implanted into a human body, the implant structure does not loose off.
Description
Technical field
The present invention is about a kind of doctor's implant structure of giving birth to, and implant structure is cured in giving birth to of particularly a kind of surperficial biologically active material and nanoscale hole, and does the surface-treated method to giving birth to doctor's implant structure.
Background technology
Generally speaking, plant body behind implant into body, pathological changes takes place around must avoiding causing tissue, just plant body and can not discharge or dissociate noxious substance, can not cause the reaction of blood coagulation (blood coagulation) or haemolysis (hemolysis), the therefore head thing compatibility (biocompatibility) of living again on material is selected.
Often being applied at present to give birth to the metal material that the doctor plants body is rustless steel, titanium alloy, chromium-cobalt alloy etc., wherein again with the most normal use of titanium, except that the metal scale engineering properties is good, when titanium is exposed in air, the water or in the organism, can spontaneously generate the oxide layer of high stability and have splendid biocompatibility, point out that according to research the titanium deoxid film of anatase (anatase) structure can effectively improve absorption of proteins, and reduce the generation of fibrous tissue; But because of titanium dioxide has the character of biologically inert, if this implant will be fixed in the relatively poor organism of bone health, it will be good not as what expect with surrounding tissue and bone restoration situation own and effect relatively.
Planting body with root of the tooth is example, if root of the tooth is planted the material that body is selected tool chemical stability and surface smoothness, then more can toxigenicity and zest, but this kind material surface is smooth, can produce reaction and bond with surrounding tissue hardly, therefore can around root of the tooth is planted body, form about 0.1～10 μ m fibrous capsule (fibrouscapsule).
Because this peplos is not to plant bulk phase with root of the tooth to be connected, and under the situation that peplos continues to thicken, can block the supply of surrounding tissue blood flow, cause the accumulation of root of the tooth surrounding tissue refuse to cause inflammation to form cyst; In addition, peplos calcification and sclerosis are urged to root of the tooth and plant the body surrounding tissue, also can cause local pain; In addition, owing to be subjected to unbalanced stress even, and cause root of the tooth to plant body or surrounding tissue is impaired, pain or artificial tooth root get loose phenomenon.
For fear of the problem of above-mentioned peplos, can plant the surface at root of the tooth on the traditional handicraft and carry out surface treatment.And root of the tooth is planted the mode that handle the surface, comprise that planting the surface at root of the tooth does the blasting treatment of etching or interior pit holeization, root of the tooth is planted the surface does the lining coating and handle, or sintered particles forms the sintering process of hole in planting the surface.
At traditional blasting treatment, because blasting treatment is to utilize kinetic energy bump, so the distance that blasting treatment root of the tooth is later planted between the hole of surface is bigger, and size dimension differs, mechanical strength a little less than; And the hole degree of depth there is no too big help at micrometer range for hyperplasia, attaching, differentiation; In addition, after surface treatment is intact,, behind implant into body, cause allergic phenomena easily if do not have through careful cleaning and sterilization; In addition, the mode that the hole of blasting treatment generates because there is not selectivity, therefore can produce reaction in stressed bigger part, and root of the tooth is planted cognition and collapsed or deformation because of the stressed young's modulus that surpasses itself produces.
Do the mode that the lining coating is handled and plant the surface at root of the tooth, because root of the tooth is planted the surface and coating does not have any chemical bonded refractory each other, behind implant into body, warp causes obscission for a long time and loses former having the ability easily.
As for the sintering rule is that the high temperature that adopt are issued to the surfaction effect more, change and make physics and chemical property change but tend to cause root of the tooth to plant the body crystalline phase in pyroprocess, so the selection that root of the tooth is planted the body material limits to some extent.
In addition, plant body itself,, also can add various growth material in order to promote the hyperosteogeny of periodontal tissue at root of the tooth.The relevant method that active material is coated on the metal material has a lot of modes, and wherein the mode of accepting extensively most is the plasma spraying method.The problem of plasma spraying method fixed form is, because plasma spraying is to carry out under 1000 ℃ of high temperature, except somatomedin is deposited on the carrier, can make the somatomedin instability under the high temperature and produce many noncrystalline phases, and then influence purity and the conjugation that root of the tooth is planted body and somatomedin, it is different with the thermal coefficient of expansion of somatomedin to add that root of the tooth is planted body, can cause great stress between interface, easily at implant into body through for a long time with after body fluid contacts, cause obscission and lose and organize between adhesion, and the method also can't be planted the growth material held stationary in the body in the root of the tooth of porous character.
In TaiWan, China patent application TWO93117549, provide a kind of living doctor's implant and method for making thereof, and exposure utilizes electrochemical means to form hole on the orthopaedics implant surface with sucked type nano aperture.Though utilize this method can form a plurality of nano apertures, being characterized as of its surface hole defect is not separate to link to each other between hole wall and hole wall, implant may be too weak on overall mechanical strength, when implant is stressed, may cause and plant body deformability or avalanche because of independent pore space structure.And it does not disclose the method that how active substance is coated in the hole.
Therefore, how overcoming above-mentioned root of the tooth and plant the defective that handle the surface, can provide periodontal tissue's hyperosteogeny again, take into account the mechanical strength of implant structure simultaneously, is the problem that institute of the present invention desire solves.
Summary of the invention
In view of this, main purpose of the present invention provides living doctor's implant structure that a kind of hole optionally generates in pitch, wherein give birth to doctor's implant structure surface and have screw thread and a plurality of nanoscale hole, those holes only are distributed in the zone between those screw threads and the screw thread, giving birth to doctor's implant structure can be in response to increase bioactive substance again with demand, strengthen and biocompatible and bone conformability, therefore, also comprise a bioactive substance at the described doctor's implant structure of giving birth to, be distributed in implant structure top layer and those holes.
Another object of the present invention provides a kind ofly does the surface-treated method to implant structure, and comprising: an implant structure is provided, and the material of implant structure is a metal; Implant structure is carried out cleaning surfaces; Impose a heat treatment, can under environment such as vacuum, inertia, passivity gas, carry out; Then, form the burning layer film in the implant structure surface, and form a plurality of nanoscale holes, wherein, utilize the employed electrolyte of anodising mode to contain fluorion, for example ammonium fluoride in the implant structure surface in the anodising mode; At last, can strengthen and biocompatible and bone conformability, fix a bioactive substance and be distributed in implant structure top layer and those holes in response to increase bioactive substance again with demand.
Use selective surface provided by the present invention to handle the tool thread structure and give birth to the method that the doctor plants body, the implant structure after the processing has following advantage:
The nanoscale hole only selectivity be created on zone between implant structure thread surface and the screw thread, when implant structure is stressed, the relatively more weak place, screw thread place of intensity is not easy because of stressed deformation or avalanche to take place, and causes implant structure to get loose behind implant into body.
2. the generation direction of nanoscale hole has very strong unicity, makes implant structure inside can not reduce the mechanical strength of implant structure because of communicating between the hole.
3. increase the contact area and the bone guided (Osteoconductive) of implant structure and osseous tissue, allow osteocyte be easy to growth.
4. can the electrochemical deposition mode scatter or the filled biomass active substance in the hole of implant structure, make implant structure behind implant into body, have osteoinductive (Osteoinductive), make the active increase of osteocyte, integrate (Osseointegration) time with the bone that reduces implant structure and tissue.
To sum up, after implant structure is handled by surface treatment method provided by the present invention, can be by increasing the surface area of tissue and implant structure contact, promote hyperosteogeny, reach the function that bone guided (Osteoconductive), bone are induced (Osteoinductive), effectively shorten bone and integrate (Osseointegration) time, needed rehabilitation period after the shortening patient underwent operative.
Description of drawings
Figure 1A embodiment of the invention root of the tooth is planted the sketch map of body implant into body;
The root of the tooth implant structure of Figure 1B embodiment of the invention;
The root of the tooth implant structure partial enlarged drawing of Fig. 1 C embodiment of the invention;
Fig. 1 D is along the profile of A-A transversal among Fig. 1 C;
The flow chart of Fig. 2 surface treatment method of the present invention; And
When Fig. 3 A～3D carries out anodising, the hole generative process sketch map on implant structure surface.
The component symbol explanation
1 ... root of the tooth implant structure 10 ... the nanoscale hole
11 ... bioactive substance 12 ... screw thread
120 ... zone 13 between screw thread and the screw thread ... the oxide layer thin film
The specific embodiment
About selective surface of the present invention handle the tool thread structure give birth to method that the doctor plants body with and give birth to doctor's implant structure, can pass through following detailed description and appended graphic, be further understood.
In order proposed by the invention the giving birth to of clearer description to cure the feature of planting body, now cooperate graphic being described in detail as follows.The doctor's implant structure of giving birth to proposed by the invention has screw thread, can be applicable to root of the tooth and plants body, nail, hone lamella or the like.In the present invention, as an embodiment, cooperate diagram to give a detailed account with a root of the tooth implant structure.
Please refer to Figure 1A～1D, Figure 1A shows the sketch map of the embodiment of the invention, is the root of the tooth implant structure 1 actual situation of implanting dental bed of the present invention.Figure 1B is the root of the tooth implant structure of the embodiment of the invention.
Because implant structure is behind implant into body, need to consider can not cause implant structure surrounding tissue generation pathological changes, therefore its material must be selected the material of tool biocompatibility for use, arbitrary prior biological compatibility metal or metal alloy material all can be selected for use, is to select the material of titanium as root of the tooth implant structure 1 for use in the present invention.
This be because titanium except the metal scale engineering properties is good, its surface forms easily titanium dioxide, belongs to inert ceramic material, is not easy and other material produces reaction; Titanium dioxide has ratio aluminum oxide and the better biocompatibility of zirconium oxide, therefore, when titanium dioxide converts rutile structure to, can improve biocompatibility; In addition, the surperficial acid and alkali-resistance that titanium dioxide constitutes effectively prevents disengaging of titanium ion.
Fig. 1 C is the root of the tooth implant structure partial enlarged drawing of the embodiment of the invention, and Fig. 1 D is along the profile of A-A transversal among Fig. 1 C.Wherein root of the tooth implant structure 1 surface has a plurality of nanoscale holes 10 and a bioactive substance 11.
Grow up in order to allow osteocyte can attach root of the tooth implant structure 1, increase its biological adhesion, root of the tooth implant structure 1 surface can have a plurality of nanoscale holes 10, and hole opening average diameter size about 10 is to 500nm.Because root of the tooth implant structure 1 is behind implant into body, need consider that also the mechanical strength of implant structure can not be too a little less than, therefore, hole opening average diameter size about 10 to 80nm be the best.In embodiments of the present invention, the spacing of adjacent two holes needs at least greater than 5nm.The size of spacing then adjusts according to the situation of user.
Bioactive substance 11 is distributed in root of the tooth implant structure 1 top layer and the hole 10, to increase the compatibility and the bone conformability of root of the tooth implant structure 1 and organism, as Fig. 1 D.Bioactive substance 11 can promote hyperosteogeny, and reaches the function that bone guided (Osteoconductive), bone are induced (Osteoinductive), effectively shortens bone and integrates (Osseointegration) time.This bioactive substance 11 is selected the material that comprises calcium, P elements and hydroxy for use.In a preferred embodiment, bioactive substance 11 is selected calcium phosphate material for use, with the usefulness of oxyhydrogen-base apatite as the bone joint, because oxyhydrogen-base apatite be Ca/P not ear than being 1.67 very approaching with the Ca/P value 1.6 of skeleton, have and induce ossified effect, be beneficial to osteocyte attaching and growth, increase its biological adhesion, make newborn bone and bone form stronger chemical bonded refractory.
Be noted that in embodiments of the present invention shown in Figure 1B, root of the tooth implant structure 1 surface also has screw thread 12, so that root of the tooth implant structure 1 is fixed in the dental bed.Because the mechanical strength of screw thread 12 compared to the zone 120 between screw thread and the screw thread a little less than, therefore, aforesaid nanoscale hole 10 only is distributed in the zone 120 between screw thread and the screw thread.
The present invention provides a kind of selective surface to handle the tool thread structure simultaneously and gives birth to the method that the doctor plants body.With reference to Fig. 2, be the flow chart of the embodiment of the invention.Implant structure is done the surface-treated purpose, promptly be to allow the implant structure surface form a plurality of nanoscale holes, allow osteocyte be easy to growth.Method provided by the present invention is not limited to the employed implant structure of the embodiment of the invention, and other saves implant as the pass, or the bone surgery implant or the like, also can use method of the present invention to form hole on the surface, and bioactive substance.What the embodiment of the invention provided does the surface-treated method to implant structure, comprising:
S10: at first provide a life with screw thread to cure implant structure.As previously mentioned, giving birth to doctor's implant structure is a root of the tooth implant structure 1 in embodiments of the present invention.And the material of implant structure is the metal of arbitrary tool biocompatibility, and the embodiment of the invention is selected titanium or the titanium alloy material as root of the tooth implant structure 1 for use;
S15: carry out cleaning surfaces to giving birth to doctor's implant structure.Because the titanium test piece of tool blemish or impurity has very big influence in nano aperture generates, therefore before preparation, need to carry out cleaning surfaces to giving birth to doctor's implant structure as much as possible.In the embodiment of the invention, utilize acetone, ethanol, deionized water to vibrate to remove surperficial oil stain and dirty respectively at ultrasound.
S20: do heat treatment to giving birth to doctor's implant structure, make and give birth to the original stress effect disappearance of doctor's implant structure and increase its oxide layer density.When doing heat treatment, can be chosen in vacuum, carry out under inertia or the passivity gas.The purpose of this step is that hole is only formed in the zone between screw thread 12 and screw thread 12 120, and is not formed at the jut of screw thread 12 as far as possible.Because stressed bigger,, when root of the tooth implant structure 1 is stressed, easily make the more weak relatively place, screw thread place of intensity fragile more if also form hole in this part at the threaded bosses place.
Because common metal is strong in place, tip oxidizing force, it is also more to be heated when heat treatment, therefore makes original oxide layer thin film 13 more fine and close behind heat treatment, and the effect of similar protective layer makes when anodising, reduces the generation of threaded bosses part hole.And, do heat treatment in the environment under inertia or the passivity gas in vacuum, and be at high temperature to form too thick oxide layer thin film 13 in root of the tooth implant structure 1 surface for fear of airborne oxygen, cause follow-up when doing anodising, to be difficult to generate hole.On the other hand, in heat treatment process, also eliminate root of the tooth implant structure 1 original stress effect own and make and give birth to oxide layer thin film 13 densification and firm more that is originally contained on doctor's implant structure surface.The embodiment of the invention is in vacuum about 10
-1To 10
-8Under the environment of torr, about 200 to 900 ℃ of heat treatment temperature.Most preferred embodiment is in vacuum about 10 with life doctor implant structure
-2To 10
-4Under the environment of torr, implant structure is warming up to about 600 to 700 ℃.
S25: impose electrochemical process polishing implant structure.Electrochemical polish then utilize butyl glycol ether (Ethylene Glycol Butyl ether, EG), methanol (Methanol) and cross the blended electropolishing liquid of chloric acid (PerchloricAcid).With root of the tooth implant structure 1 is anode, and (99.9%Platinum Pt) is negative electrode to platinum, under the appropriate reaction parameter, carry out electrochemical polishing treatment, after polishing finishes, test piece is soaked in absolute methanol and with the ultrasound concussion, the reactant that produces with polishing the time is removed.
S30: form burning layer film 13 in root of the tooth implant structure 1 surface in the anodising mode, and form a plurality of nanoscale holes 10 in root of the tooth implant structure 1 surface.Giving birth to doctor's implant structure surface formation hole, decapacitation makes its mechanical strength variation have seriality, and can increase the contact area of planting body and osseous tissue, and increases osteocyte or osseous tissue mechanical chimeric (interlocking) effect.
The electrolyte of anodising contains fluorion, and the embodiment of the invention is to use ammonium fluoride (NH
4F) collocation ethylene glycol (Ethylene Glycol, EG) and deionized water as electrolyte, and respectively with platinum (99.9%Platinum, Pt) be negative electrode, (material is pure titanium to implant structure, 99.5%Titanium) be anode, connect with the mains the respectively negative, positive utmost point of supply of the two poles of the earth is put into electrolyte and is carried out anodising.Change experiment parameter, apply current potential, electric current, response time, reaction temperature, electrolyte water content, fluorinion concentration as reaction, the size of may command hole opening.Such as in embodiments of the present invention, wide open mouthful of average diameter about 10 of control hole be preferably 10 to 80nm, and the spacing of adjacent two holes needs at least greater than about 5nm to 500nm, with the overall mechanical strength of assurance root of the tooth implant structure 1.Therefore, the concentration about 0.1 of control ammonium fluoride is to 20wt%, but when experiment test of the present invention, ammonium fluoride concentration about 0.1 can obtain optimum to 0.4wt%.And apply about 10 to 90 volts of voltage range, about 40 volts of optimal parameter.About 5 minutes to 1200 minutes of response time.
Behind anodising, carry out cleaning step S301 once more, test piece is soaked in the absolute methanol, and with ultrasound concussion machine concussion 20 minutes, to remove remained on surface electrolyte.
Wherein, in the anodising process, form the mechanism of burning layer film 13, please refer to Fig. 3 A～3D, when carrying out anodising, give birth to the sketch map of doctor's implant structure surface hole defect generative process for method of the present invention.With the titanium of the embodiment of the invention, be because in the anodising process, apply current potential in root of the tooth implant structure 1 (titanium), make it to take place oxidation reaction, produce titanium ion (Ti
4+), cause the anode part chemolysis, as reaction equation (1), and the electrolysis of water takes place simultaneously, make hydrone be dissociated into oxonium ion (O
2-) and hydrion (H
+), as reaction equation (2).Titanium ion combines with oxonium ion, forms the oxide layer thin film 13 of titanium in the surface, as reaction equation (3), causes the ohmic polarization phenomenon, is referred to as barrier layer (barrier layer), as shown in Figure 3A;
Ti+4e
-→Ti
4+ (1)
H
2O→2H
++O
2- (2)
Ti
4++2O
2-→TiO
2 (3)
Then, forming nanoscale hole 10, is because fluorion (F
-) will replace the position of oxonium ion, with Ti
4+Form [TiF
6]
2-Ion misfit thing, as the formula (4), titanyl layer film 13 is produced partial chemolysis (chemical dissolution), make barrier film generation ionizing and be porous porous layer (porous layer), shown in Fig. 3 B:
TiO
2+6F
-+4H
+→[TiF
6]
2-+2H
2O (4)
Along with the time continue to prolong, electric field and fluorion continue to increase the weight of to the topochemistry dissolution degree that titanium and thin film of titanium oxide 13 are caused, and the degree of depth of hole and width can strengthen gradually, change nano tubular structure into.Because the nanotube walls structure is looser, and be the fine and close structure of structure at the bottom of the mouth of pipe and the pipe, so the response time is of a specified duration more, the degree of depth of nanoscale hole is dark more, and the aperture is big more, but the spacing between two adjacent holes is more little, shown in Fig. 3 C and 3D.
It should be noted that with of the present invention and cure implant structure surface-treated method to giving birth to, when forming nanoscale hole 10, it generates direction and has very strong directivity, shown in Fig. 3 A～3D.Be not connected owing to give birth between the inner hole of doctor's implant structure, can not cause integrally-built avalanche, and can keep certain mechanical strength.
By the theory of blemish as can be known, defective promptly is made of than institutes such as out-of-flatness part, difference row, hole, crystal boundary, surperficial precipitates the surface; Because the current potential that applies is the DC voltage at single direction, single plane, and (Free Energy) is lower for the fault location free energy, and therefore when electric field applied, electric charge was gathered in the fault location on surface earlier, the polarization phenomena that cause electric charge accumulation and electric field to concentrate, and generating unit is divided the chemistry dissolving; Add owing to contain fluorion (F in the electrolyte
-), so fluorion will replace the oxonium ion position in the titanium oxide and produce ion misfit thing [TiF with titanium
6]
2+, this phenomenon also causes the part chemolysis phenomenon at blemish place, because the ion misfit thing [TiF that produces
6]
2-Therefore the components and concentration contained in fault location must the concentration diffusing phenomenon occur greater than other surface portion; More than two factors be to impel the generation direction of nanoscale hole to have the reason of single direction.
In addition, be noted that the employed doctor's implant structure of giving birth to is that the root of the tooth that a surface has a screw thread is planted body in the invention process.Because previous vacuum heat step S20 makes the oxide layer of threaded portion comparatively fine and close, so in this step, when the nanoscale hole generates, can optionally be distributed in the zone between screw thread and the screw thread.
S35: a bioactive substance is distributed in root of the tooth implant structure 1 top layer and those holes, and bioactive substance mainly comprises calcium, P elements and hydroxy.Be with electrodeposition process bioactive substance to be distributed in to give birth in doctor implant structure surface and the hole in the embodiment of the invention, but in fact be not limited in this mode of utilizing, also can utilize prior art that bioactive substance is coated in and give birth to doctor's implant structure, such as: modes such as plasma spraying method, impregnation method, sol-gel process, ion sputtering deposition method.
Comprise phosphorus and calcium ion during plating in the employed electrolyte.At first, utilize calcium and phosphorus predecessor, as: CaCl
2, NH
4H
2PO
4Deng, be dissolved in the deionized water, as the supplier of calcium and phosphorus.Implant structure (99.5%Titanium is cured in intact the giving birth to of anodising, Ti) be fixed in negative electrode, anode then be platinum (99.9%Platinum, Pt), after inserting two utmost points in the electrolysis bath, fill or be coated in nano aperture to carry out bioactive substance under the appropriate reaction parameter.Parameter comprises that reaction applies current potential, response time, reaction temperature and electrolyte content and forms or the like, and adjusts proper pH value.
S40: the test piece after the plating with washed with de-ionized water after in the baking oven inner drying.
Though the present invention illustrates as above with preferred embodiments, so it is not in order to limit the present invention.Allly be familiar with this technical staff, when understanding and utilize other element or mode to produce identical effect easily.Therefore, the modification of being done in not breaking away from spirit of the present invention and protection domain all should be included in the scope of the application's claim protection.
Claims (19)
1. give birth to doctor's implant structure for one kind, it is characterized in that, this life doctor implant structure surface has screw thread and a plurality of nanoscale hole, and those holes are distributed in the zone between those screw threads and the screw thread.
2. the doctor's implant structure of giving birth to as claimed in claim 1 is characterized in that, this life doctor implant structure is a root of the tooth implant structure, and material is a metal or alloy.
3. the doctor's implant structure of giving birth to as claimed in claim 2 is characterized in that, this life doctor implant structure material is a titanium.
4. the doctor's implant structure of giving birth to as claimed in claim 1, it is characterized in that, this life doctor implant structure also comprises a bioactive substance, is distributed in this life doctor implant structure top layer and those holes, to increase the compatibility and the bone conformability of this life doctor's implant structure and organism.
5. the doctor's implant structure of giving birth to as claimed in claim 4 is characterized in that this bioactive substance contains calcium, P elements and hydroxy.
6. the doctor's implant structure of giving birth to as claimed in claim 1 is characterized in that the spacing of any two holes is approximately greater than 5nm, and the average diameter size of those hole openings about 10 is to 500nm, and the generation direction of those holes has single direction.
7. a selective surface handles the method that the tool thread structure is given birth to doctor's implant structure, it is characterized in that, comprising:
Provide and cure implant structure all one's life, the surface of this life doctor implant structure has screw thread, and material is a metal or alloy;
Clean this life doctor implant structure surface;
Impose a heat treatment in this life doctor implant structure; And
The anodising mode that imposes is in this life doctor implant structure, to form this burning layer film in this life doctor implant structure surface, and in a plurality of nanoscale holes of this living doctor's implant structure surface formation, those hole selective growth zones between those screw threads and screw thread, wherein, the employed electrolyte of this anodising mode comprises fluorion.
8. method as claimed in claim 7 is characterized in that, imposes heat treatment when this life doctor implant structure, is in vacuum, does heat treatment under inertia or the passivity gas.
9. method as claimed in claim 7 is characterized in that, imposing heat treatment is in vacuum about 10 in this implant structure
-1To 10
-8Under the environment of torr, and this implant structure heat-treats in about 200 to 900 ℃, to increase the density that this plants the body oxide layer on surface of material.
10. method as claimed in claim 7 is characterized in that, this life doctor implant structure is a root of the tooth implant structure, and the material of this implant structure is titanium or titanium alloy.
11. method as claimed in claim 7 is characterized in that, imposes a heat treatment behind this life doctor implant structure, before with anodising this implant structure being handled, also comprises:
Use butyl glycol ether, methanol and cross the blended electropolishing liquid of chloric acid, this implant structure is carried out polishing with electrochemical means; And
This implant structure is soaked in absolute methanol and cooperates a ultrasonic energy that this implant structure is shaken, the reactant that produces with polishing the time is removed.
12. method as claimed in claim 7 is characterized in that, when with anodising this implant structure being carried out surface treatment, employed electrolyte comprises ammonium fluoride, ethylene glycol and deionized water, and wherein, the concentration of ammonium fluoride about 0.1 is to 20wt%.
13. method as claimed in claim 12 is characterized in that, when imposing anodising this implant structure being carried out surface treatment, the concentration of ammonium fluoride about 0.1 is to 0.4wt%.
14. method as claimed in claim 7 is characterized in that, also comprises a bioactive substance is distributed in this implant structure top layer and those holes behind anodising, with biocompatible and the bone conformability that increases this implant structure.
15. method as claimed in claim 14 is characterized in that, when being distributed in this bioactive substance in this implant structure top layer and those holes, can select electricity consumption sedimentation, plasma spraying method, impregnation method, sol-gel process or ion sputtering deposition method.
16. method as claimed in claim 14 is characterized in that, this bioactive substance contains calcium, P elements and hydroxy.
17. method as claimed in claim 14 is characterized in that, when making this bioactive substance be distributed in this life doctor implant structure top layer and those holes, is to use electrodeposition process, and, comprise phosphonium ion and calcium ion in the employed electrolyte.
18. method as claimed in claim 7 is characterized in that, when carrying out anodising, and about 10 to 90 volts of institute's making alive, about 5 minutes to 1200 minutes of response time.
19. method as claimed in claim 7, it is characterized in that, with anodising this implant structure is carried out surface treatment when forming a plurality of nanoscale hole, the average diameter size of those hole openings about 10 is to 500nm, the voltage, electric current, response time, reaction temperature, the fluorinion concentration that are applied in the time of can be according to anodising are controlled, and the generation direction of those nanoscale holes has single direction.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103027740A (en) * | 2013-01-17 | 2013-04-10 | 北京中奥汇成生物材料科技有限公司 | Absorbable bone screw with slow-release biological factor and preparation method thereof |
| CN104955416A (en) * | 2012-12-27 | 2015-09-30 | 钛格兰技术有限公司 | Dental implant unit |
| CN106637351A (en) * | 2017-01-09 | 2017-05-10 | 佛山市安齿生物科技有限公司 | Be used for colored fixing device of dental implant base station |
| CN114176807A (en) * | 2021-12-08 | 2022-03-15 | 北京航空航天大学 | Multifunctional micro-implant anchorage nail and design and manufacturing method thereof |
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| US6241770B1 (en) * | 1999-03-05 | 2001-06-05 | Gary K. Michelson | Interbody spinal fusion implant having an anatomically conformed trailing end |
| TW200600122A (en) * | 2004-06-17 | 2006-01-01 | Wen-Ching Say | Biomedical implant comprising sucking nano-hole and a method of preparation thereof |
| WO2006031096A1 (en) * | 2004-09-14 | 2006-03-23 | Oratio B.V. | Method of manufacturing and installing a ceramic dental implant with an aesthetic implant abutment |
| CN1817319A (en) * | 2005-12-26 | 2006-08-16 | 浙江大学 | Production of porous structure with biological activity on surface of pure-titanium tooth implantation |
-
2010
- 2010-04-21 CN CN 201010166884 patent/CN102232875B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1190878A (en) * | 1995-06-07 | 1998-08-19 | 加里·K·米切尔森 | Translateral spinal implant |
| US6241770B1 (en) * | 1999-03-05 | 2001-06-05 | Gary K. Michelson | Interbody spinal fusion implant having an anatomically conformed trailing end |
| TW200600122A (en) * | 2004-06-17 | 2006-01-01 | Wen-Ching Say | Biomedical implant comprising sucking nano-hole and a method of preparation thereof |
| WO2006031096A1 (en) * | 2004-09-14 | 2006-03-23 | Oratio B.V. | Method of manufacturing and installing a ceramic dental implant with an aesthetic implant abutment |
| CN1817319A (en) * | 2005-12-26 | 2006-08-16 | 浙江大学 | Production of porous structure with biological activity on surface of pure-titanium tooth implantation |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104955416A (en) * | 2012-12-27 | 2015-09-30 | 钛格兰技术有限公司 | Dental implant unit |
| CN103027740A (en) * | 2013-01-17 | 2013-04-10 | 北京中奥汇成生物材料科技有限公司 | Absorbable bone screw with slow-release biological factor and preparation method thereof |
| CN106637351A (en) * | 2017-01-09 | 2017-05-10 | 佛山市安齿生物科技有限公司 | Be used for colored fixing device of dental implant base station |
| CN114176807A (en) * | 2021-12-08 | 2022-03-15 | 北京航空航天大学 | Multifunctional micro-implant anchorage nail and design and manufacturing method thereof |
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| CN102232875B (en) | 2013-05-01 |
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