CN102245259A - 可摄入的治疗激活器系统及方法 - Google Patents

可摄入的治疗激活器系统及方法 Download PDF

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CN102245259A
CN102245259A CN2009801496340A CN200980149634A CN102245259A CN 102245259 A CN102245259 A CN 102245259A CN 2009801496340 A CN2009801496340 A CN 2009801496340A CN 200980149634 A CN200980149634 A CN 200980149634A CN 102245259 A CN102245259 A CN 102245259A
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CN102245259B (zh
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马克·兹德布利克
马克·延森
奥利弗·科利乌
安吉拉·斯特兰德
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Proteus Digital Health Inc
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Abstract

本发明提供了一种可摄入的治疗激活器系统和方法。在一个方面，所述可摄入的治疗激活器包括具有效应器模块以发送效应器指令的可摄入的装置以及与治疗装置相连的响应器模块。所述响应器模块可以接收和处理效应器指令，从而引起治疗装置的响应。治疗装置响应的实例包括激活治疗、使治疗失活、调节治疗以及中止治疗。

Description

可摄入的治疗激活器系统及方法
相关申请及交叉引用
本申请要求于2008年11月13日提交的美国临时申请序列号61/114,422号的权益，其全部公开内容以引用的方式并入本文。
技术领域
本发明大体上涉及医学治疗系统、装置和方法。更具体地，本发明涉及使用可摄入的电子装置来激活和/或调节各种医学治疗的系统、装置和方法。
背景技术
对各种与健康相关的病症、事件及缺陷有多种疗法。可以以植入装置的方式实施这些疗法，例如，心律调节装置、神经刺激/神经调节装置、鞘内药物递送泵以及功能性神经调节假体(例如，耳蜗植入物、视网膜植入物以及人造关节、肢体和器官)。然而，一旦植入，这些装置可能不提供有利于受控激活或调节的功能。
在一个实例中，神经刺激装置可将疼痛控制治疗递送到脊柱，但神经刺激装置可能不会按要求来激活。换句话说，神经刺激装置在植入后始终是被激活的。结果，当不需要这样的治疗时，患者也会经受神经刺激以及与其相关的有害的副作用。
在另一实例中，神经调节装置(诸如脊髓刺激器)可为疼痛提供治疗益处，然而，刺激的速率不可调节以按照患者的生活方式来调整刺激，例如，在活动多时强度较高，而活动少时强度较低。结果，患者可能需要限制不符合刺激强度的活动以获得最佳的疗效，或在从事不符合要求的活动时获得较差的疗效。
因此，希望具有用于控制治疗、优化疗效以及在不对患者设置限制的情况下增强对患者治疗的系统、装置和方法。
发明内容
本公开包括一种用于为治疗装置提供指令的系统。所述治疗装置可以是任何类型的装置，例如，心脏治疗装置、神经刺激装置、鞘内药物递送泵、肠胃装置以及神经刺激假体。所述系统包括可摄入的装置和响应器模块。所述可摄入的装置包括为响应器模块提供效应器指令的输出或效应器模块。所述响应器模块接收和处理效应器指令，并将效应器指令传送至治疗装置，以改变治疗装置的运行。
附图说明
图1示出了包括可摄入的治疗激活器的可摄入的激活器环境。
图2更详细地示出了图1的可摄入的治疗激活器。
图3更详细地示出了图2的治疗激活器的可摄入的装置。
图4更详细地示出了图3的可摄入的装置的效应器模块。
图5更详细地示出了图2的可摄入的治疗激活器的效应器指令。
图6更详细地示出了图2的可摄入的治疗激活器的响应器模块。
图7示出了图1的可摄入的激活器环境的治疗装置。
图8示出了治疗装置经由可摄入的治疗激活器的摄入和激活。
具体实施方式
总体上，本发明可为植入的医疗装置或相关治疗提供受控的激活和/或调节。更具体地，本发明包括使用可摄入的装置来实现与可植入的医疗装置相关的装置/治疗的激活和/或调节。通常，由患者控制可摄入的装置的摄入。可摄入的装置的摄入导致患者的医疗装置和/或治疗的激活和/或调节。可选地，可摄入的装置的摄入可使装置/治疗失活或中止。因此，作为本发明新颖且有益的结果，患者和/或其他人基于可摄入的装置的提供可随意控制与各种植入的医疗装置和相关治疗有关的各种结果，且医务人员或其他人可通过例如处方来控制可摄入的装置的供给。
使用可摄入的装置来激活和/或调节治疗对任何植入的装置或治疗可具有广泛的潜在应用，包括：心律调节；神经刺激和/或神经调节(有时在本文统称为“神经刺激”)；鞘内药物递送泵和治疗；以及功能性神经调节假体，例如，耳蜗植入物、视网膜植入物以及人造关节、肢体和器官。
治疗的激活包括，例如，激活装置以引起事件或状态。例如，激活具有神经刺激电极的胃束带装置可引起饱腹感增加和/或引起胃动力的速率提高。此外，可摄入的装置可激活胃束带装置的带部分，例如，使带缩紧。如果可摄入的装置在进餐前摄入，则患者可控制食欲、饱腹感、热量摄入，且最终影响体重管理结果等。
某些方面可涉及体内治疗，且可包括例如，可植入的医疗装置。如本文所使用，术语“可植入的医疗装置”是指被构造为至少部分地设置在活体上、至少部分地设置在活体内或其组合的装置。
例如，可植入的医疗装置可包括具有多种电极构造的导线，所述电极构造与控制器电路、电源等通信相连。更具体且示例性地，可植入的医疗装置可包括一条或多条具有多个同轴分段电极附属物(in-line segmented electrode satellite)的导线以及一条或多条用于多路复用多个分段电极附属物的电源/数据线，其中每个电极是独立可控的。可与本发明结合使用的装置的各种构造描述/公开在以下申请中：以WO2004/052182公开的PCT申请PCT/US2003/039524、以WO2006/029090公开的PCT申请PCT/US2005/031559、以WO2006/069322公开的PCT申请PCT/US2005/046811、以WO2006/069323公开的PCT申请PCT/US2005/046815、以WO2007/075974公开的PCT申请PCTUS2006/048944、以US2008-0114230A1公开的美国申请序列号11/939,524。
可与本发明结合使用的装置的各种构造描述/公开在以下申请中：以WO/2008/095183公开的PCT申请序列号PCT/US2008/052845以及以WO/2006/116718公开的PCT/US2006/016370。每个前述申请的全部内容都以引用的方式并入本文。前述构造仅用于说明之目的，且各种其它部件和构造也是可能的。
图1示出了包括可摄入的治疗激活器102的可摄入的治疗激活器环境100。在各个方面，可摄入的治疗激活器环境可以是生物体，例如哺乳动物，包括人类。在各个方面，可摄入的治疗激活器102可与一个或多个治疗装置108(例如，体内装置，诸如植入装置或其它装置)通过通信交互操作。可通信的相互作用可引起治疗装置108的激活和/或调节，例如，治疗装置108的即时激活、治疗装置108的延时激活、治疗装置108的即时调节、与治疗装置108相关的活动的延时调节等。以这种方式，患者可通过可摄入的治疗激活器102的摄入控制治疗结果。
图2更详细地示出了图1的可摄入的治疗激活器102。在各个方面，可摄入的治疗激活器102包括可摄入的装置200，所述可摄入的装置200具有效应器模块202、效应器指令204以及任选的响应器模块206。在摄入可摄入的装置200之后，效应器模块202可发送，例如，传输效应器指令204。效应器指令204可例如通过响应器模块206接收，并且可引起治疗装置108和/或与治疗装置108有关的治疗的激活和/或调节。此外，可同时或者在时间上非常接近地摄入多个可摄入的装置200，且多个摄入的可摄入的装置200中的每一个可与一个或多个治疗装置108相互作用。
可摄入的装置200包括能够被生物体摄入且进一步能够与效应器模块202机械地、电子地和/或通过通信交互操作的任何装置、部件、硬件和/或软件以及它们的组合，这将在下文进行描述。
为了说明，可摄入的装置200可包括、包含、被结合进空白对照结构(placebostructure)，等等。空白对照结构可包含例如胶囊、药丸等。为了进一步说明，可摄入的装置200可包括、包含、被结合进可摄入的药物，等等。可摄入的药物可包括例如胶囊、药丸、液体等，且可以是处方药、非处方药等。
各种可摄入的装置200可包含、包括、被结合进例如在以WO/2008/095183公开的PCT/US2008/052845以及以WO/2006/116718公开的PCT/US2006/016370中描述的装置等，这些申请的所有内容均以引用的方式并入本文。此外，本文所引用的所有参考文献的全部内容据此均以引用的方式并入。
于2006年4月28日提交的PCT/US2006/016370中所描述的包括组合物的药物信息学系统包括允许检测药剂到人体的实际物质递送的系统和方法。
于2008年2月1日提交的PCT/US2008/52845以及于2009年9月21日提交的美国专利申请序列号12/564,017(这两个申请均以引用的方式并入本文)中所描述的离子发射模块或可摄入的事件标记器(IEM)系统包括IEM和个人信号接收器。IEM的方面包括标识器，所述标识器可以存在或不存在于生理可接受的载体中。标识器的特征在于，一旦与身体的内部生理靶位点(诸如消化道内部靶位点)接触就被激活。将个人信号接收器构造成与生理位置(例如，身体内部或身体上)相连，并接收IEM的信号。在使用的过程中，IEM发送由个人信号接收器接收的信号。
IEM还包括沉积在IEM两侧的两种不同材料，以形成电化学势，并用作阴极和阳极以形成电源。所述不同的材料可以由通过增大电流通路来放大信号的不导电材料或裙部(skirt)隔开。更具体地，所述不同的材料可以由适用于操作IEM的环境的任何两种材料制成。例如，当与可摄入的装置一起使用时，所述不同的材料可以是具有不同的电化学势的可摄入的材料中的任何一对。示例性的实例包括当IEM与离子溶液(诸如胃酸)接触时的情况，如以下图8所示。适合的材料不限于金属，且在某些方面，成对的材料选自金属和非金属，例如由金属(例如Mg)和盐(例如CuCl或Cul)组成的对。就活性电极材料而言，具有适当不同的电化学势(电压)和低界面阻力的任何成对物质-金属、盐或嵌入化合物都是合适的。此外，控制模块(未示出)与所述两种不同的材料中的每一种电耦接，以便接收电源并被激活，以及控制传导性，并因此控制所述两种不同材料之间的电流通路。控制模块以独特的方式改变所述两种不同材料之间的传导性。通过改变所述不同材料之间的传导通路，控制模块能够通过IEM或可摄入的装置200周围的导电流体/液体来控制电流的大小。这产生携带或编码效应器指令的唯一电流信号，并且可以通过接收器如响应器模块206来检测和测量，所述接收器可以设置在身体的内部或外部。
于2007年10月17日提交的PCT/US07/82563描述的受控激活可摄入的标识器包括可摄入的组合物，例如药物信息学激活的组合物。受控激活可摄入的标识器包括受控激活元件，所述受控激活元件响应于在目标靶位点存在的预定刺激而使标识器激活。
图3更详细地示出了图2的治疗激活器的可摄入的装置200。更具体地，可摄入的装置200可与多个载体300相连，例如，如之前所述的空白对照剂、药物、胶囊等。在各个方面，多个可摄入的装置200可与单个载体300相连，例如，两个可摄入的装置200可包括在一个胶囊中；可将三个或多个可摄入的装置200附着/制造在药丸内，等。除了效应器模块202之外，可摄入的装置可包括各种其它部件302，可以整体地或部分地与各种其它元部件302结合，可以与各种其它部件302集成，等等。所述各种其它部件302的例子包括用于检测受试者的生理学参数的模块。效应器模块202包括能够接收、处理、存储、产生和/或传送图2的效应器指令204的任何装置、部件、硬件和/或软件以及它们的组合。在各个方面，例如，效应器模块202可包括集成电路(IC)、微电路、微芯片、硅芯片、小型电子电路等，其具有处理能力以接收、产生、存储效应器指令204等并具有例如通过发射器等传送效应器指令204的装置。
图4更详细地示出了图3的可摄入的装置的效应器模块202。效应器模块202可包括微芯片400、电源402和发射器404。微芯片400可包括在各种部件内，和/或可与各种部件相连，例如软件、存储装置、存储器、处理指令等，所述各种部件是接收、产生、进行信号处理和/或存储效应器指令204所必需的。
电源402可以以不同的方式构造，例如，湿电池等。在一个方面，电源402可以是不完全的电源，其可以在与靶生理位点接触时被激活。因此，电源402被激活，从而给微芯片400供电。换句话说，电源402可利用离子溶液例如胃液、血液或其它体液和一些组织中的电化学反应。
根据可摄入的装置200的构造，靶生理位点或位置可以改变，其中典型的目标靶生理位点包括但不限于：肠胃道中的位置，例如，口腔、食道、胃、小肠、大肠等。在某些方面，不论靶位点的具体组合物如何，标识器被构造成在与靶位点处的流体(例如，胃液)接触时被激活。在一些方面，标识器被构造成在组合物与靶生理位点接触后通过询问来激活。在一些方面，将标识器被构造成在靶位点处被激活，其中经过指定的时间段之后到达靶位点。
然后，微芯片400通过发射器404将并入效应器指令204的信号发送至目标，例如，直接发送至治疗装置108，通过响应器模块206发送至治疗装置108等。
在各个方面，可以使用多种通信模式、通信信道以及它们的组合。在一个实施例中，效应器指令204可通过射频(RF)信号传送。在另一个实施例中，效应器指令204可通过传导来传送，例如，使用体内电信号作为通信载体。在又一个实施例中，效应器指令204可通过传导传送至安装在患者外部的接收器，例如，响应器模块，然后响应器模块通过各种通信模式将效应器指令传送至一个或多个治疗装置108，例如植入的治疗装置。因此，可以看出，可以使用体内和体外信道的各种组合以及各种通信模式。
效应器指令204包括能够具有如之前所述功能的任何装置，例如，启动激活和/或调节，从而引起治疗装置和/或与治疗装置相关的治疗的激活/调节。
图5更详细地示出了图2中可摄入的治疗激活器的效应器指令。在各个方面，效应器指令204包括软件指令500、信号502、数据504等中的任何一个或组合。此外，如之前所述，上述任一个或全部可以以各种方式实施，并且可通过各种模式和信道来传送。
图6示出了响应器模块206，所述响应器模块206包括能够接收、处理、存储、产生和/或传送效应器指令204的任何装置、部件、硬件和/或软件以及它们的组合。在各个方面，响应器模块206可以与治疗装置108直接相连，例如，与治疗装置108机械相连。这种响应器模块204的例子包括被物理构造为心脏装置、肠胃装置、导引装置、电极装置等的部件的指令接收和/或处理装置。
在各个方面，响应器模块206可以与治疗装置108间接相连，例如，与治疗装置108电通信而不是机械相连。这种响应器模块204的例子包括被物理构造有/构造为接收器(例如可佩戴的接收器，如上面PCT/US2008/52845中所讨论的补丁接收器)的指令接收和/或处理装置。
图6更详细地示出了图2的可摄入的治疗激活器的响应器模块。在各个方面，响应器模块206可包括接收效应器指令204的接收器600、处理效应器指令204和/或存储效应器指令204等的微芯片400，以及任选的向前传送效应器指令的发射器404。
例如，接收器600可以是专用的，即只接收效应器指令，或者可以是通用的，即，可以接收除了效应器指令以外的信号、数据等。在通用接收器的情况下，这种多种类型通信的接收可提供复杂的装置功能，例如，接收起搏信号和效应器指令的心脏起搏装置。
现在参照图4，例如，微芯片400可进行有关效应器指令的各种处理活动。一个实施例包括从一个或多个可摄入的装置汇集多个效应器指令。另一个实施例包括通过效应器指令从其它来源(例如，其它装置)收集数据。为了说明，响应器模块206可从心脏装置接收和存储与心脏起搏有关的数据。例如，使心脏起搏的速率从每分钟70次减慢至每分钟60次的效应器指令。当接收到效应器指令时，微芯片可以分析数据，并基于分析的结果，修改效应器指令，以将速率减慢到每分钟65次。(在分析数据之后，可发现这个速率优选地每分钟65次，如最初所设想的。)以这种方式，响应器模块206和效应器模块202可以协同地实现最佳的治疗。
例如，发射器404可将一个或多个效应器指令204、数据或其组合发送到目标装置，例如，治疗装置108。如之前所述，通信模式和信道可以是各种类型以及它们的组合。
治疗装置108可以是能够提供或有利于生物的至少一种医学疗法的任何装置。具体地，治疗装置108包括可植入的装置。
图7示出了图1的可摄入的激活器环境的治疗装置。所述治疗装置包括例如心脏装置、导引装置、电极装置、偏头疼装置、泌尿装置、肠胃装置等。
治疗装置可以以各种方式激活和/或调节，例如，机械驱动、电激活、其组合等。在机械驱动的一个实施例中，由肠胃装置(诸如胃束带装置(GBD))接收的效应器指令使GBD对与GBD的夹紧装置相连的控制器电路发信号。然后，控制器电路产生使夹紧装置膨胀所需要的控制，从而收缩食道，从而引起更大的饱腹感，减少摄取食物的能力，改善胃动力等。
在电激活的一个实施例中，由电极装置(诸如神经刺激装置(NSD))接收的效应器指令使NSD对与其相连的控制器电路发信号。然后，控制器电路通过电极产生提供电刺激所需要的指令，从而掩盖疼痛，刺激心脏收缩等。
图8示出了治疗装置通过可摄入的治疗激活器的摄入和激活。如图所示，由人800摄入可摄入的治疗激活器200，从而使得治疗激活器200由胃液激活。一旦被激活，可摄入的治疗激活器200就将效应器指令204发送到与心脏起搏装置804相连的控制器电路808。在通过控制器电路808接收和处理效应器指令204后，指令被发送到心脏起搏装置804，从而通过心脏起搏装置804引起心脏起搏速率的变化。以这种方式，患者可控制并最终优化患者的心脏治疗的某些特征、方面和参数。
继续对前述做进一步的图示，使用于偏头痛处理的神经刺激装置起作用，例如，对与偏头痛相关的神经区域进行电刺激，可使得疼痛消失或疼痛减轻。如果可摄入的装置在出现偏头痛先兆(即，常常在周期性偏头痛之前的感觉障碍)时使用，则患者可完全避免周期性偏头痛以及与其相关的严重的疼痛。
使具有电极的泌尿治疗装置起作用以刺激排泄活动，可有助于调节急迫性失禁和失禁问题。
使与阴茎勃起有关的电极装置起作用可成功治疗多种与阳萎有关的疾病，包括勃起障碍。
使多种心脏装置起作用以激活/调节心脏治疗可实现心脏治疗改善、心脏治疗优化、习惯化减少、习惯化消除以及习惯化避免中的任何一种或多种。
在多种身体活动之前使与脊髓刺激有关的NSD起作用可以实现疼痛控制治疗改善、疼痛控制治疗优化、习惯化减少、习惯化消除以及习惯化避免中的任何一种或多种。
技术人员应注意到，各种方面对治疗的患者的至少一些控制措施是有利的。
前述内容说明了与本发明有关的有益结果的一些简单的实施例。本发明的应用以及所得到的有益结果是非常多的，不能在此全部列出。
各个方面包括以下步骤：摄入具有效应器模块的可摄入的装置；通过效应器模块发送效应器指令；以及通过与治疗装置相连的响应器模块接收并处理效应器指令，从而使得治疗装置做出响应。
各个方面包括可摄入的治疗激活器，所述可摄入的治疗激活器包括具有效应器模块和效应器指令的可摄入的装置。
各个方面包括成套工具，所述成套工具包括可摄入的治疗激活器和治疗装置。而且，成套工具还包括与可摄入的治疗激活器和治疗装置中的至少一个相连的响应器模块。
本发明的一个或多个方面可以是计算机可读介质的形式，所述计算机可读介质具有存储在其上的用于实施各种方法或各种步骤的程序。所述计算机可读介质可以是例如以下形式：计算机磁盘或CD、软盘、磁“硬卡”、服务器，或其它能够包含数据等，以电子、磁性、光学的方式或通过其它手段存储的任何其它计算机可读介质。因此，所存储的体现用于实施本方法的步骤的程序可被传递或传送至处理器，例如，通过使用计算机网络、服务器或其它交互连接，例如，因特网或其它中继装置。
应理解，本发明不限于所描述的特定的方面，且其本身可以变化。还应理解，本文所使用的术语仅用于描述特定的方面，且目的不在于进行限制，因为本发明的范围将仅由所附权利要求书来限定。
在提供了数值范围的情况下，应理解，除文中另外清楚地说明外，在该范围的上限和下限之间的以及任何其它规定的每个中间值或在该规定范围内的中间值，都包含在本发明的范围内，其中下限精确到十分位。这些较小范围的上限和下限可独立地包括在较小的范围内，并也包含在本发明的范围内，属于在该规定范围内的任何被具体排除的界限。在规定的范围包括一个或两个界限的情况下，排除那些所包含的界限中的一个或两个的范围也包括在本发明内。
某些范围出现在本文中，其数值前面带有术语“约”。术语“约”在本文中用于针对其前的准确数值以及接近或近似其前的数值提供文字支持。在确定一个数值是否接近或近似所具体引用的数值时，接近或近似的未引用的数值可以是这样的数值，在其所出现的上下文中提供所具体引用的数值的实质等同值。
除非另有定义，本文所使用的所有科技术语所具有的含义都与本发明所属领域的普通技术人员通常所理解的意思相同。尽管还可以在实践中或在测试本发明时使用类似于或等同于本文所描述的那些的任何方法和材料，但是现在描述的是具代表性的说明性的方法和材料。
本说明书所引用的所有出版物和专利都以引用方式将其全部内容并入本文，就如同每个独立的出版物或专利都被明确且独立地指出以通过引用的方式并入，所有出版物和专利以引用的方式并入本文以公开和描述与所引用的出版物有关的方法和/或材料。对任何出版物的引用是针对其在提交日之前的公开，并且不应被解释为承认本发明由于之前的发明而不早于这种出版物。而且，所提供的出版日期可能与实际的出版日期不同，可能需要独立地确认实际的出版日期。
应注意，当在本文以及所附权利要求中使用时，单数形式的“一个”、“一种”以及“所述”包括复数指代物，除非文中另有明确的说明。进一步注意的是，权利要求可以撰写为排除任何可选的要素。因此，这一说明的目的是用作与权利要求要素的引用有关的排他性的词语例如“仅”、“只有”等的使用或“否定”限定的使用的前提基础。
在阅读了该公开内容之后，对本领域技术人员显而易见的是，本文所描述和说明的独立的方面中的每一个都具有独立的部件和特征，在不偏离本发明的范围或精神的情况下，所述独立的部件和特征可容易地与其它若干方面中的任何一种的特征分离或组合。任何所引用的方法可以按所引用的事件的顺序实施或可以按逻辑上可能的任何其它顺序实施。
虽然为了理解清楚的目的已经通过说明和举例的方式相当详细地描述了前述发明，但是，对本领域的普通技术人员显而易见的是，在不偏离所附权利要求书的精神或范围的情况下，根据本发明的教导可以对本发明做出某些改变和修改。
因此，前述内容仅说明了本发明的原理。应理解，本领域的技术人员能够设计出各种装置，这些装置虽然没有在本文明确描述或示出，但其可以体现本发明的原理，并被包括在其精神或范围内。此外，本文所引用的所有例子和条件性的语言都主要旨在帮助读者理解本发明的原理以及发明人所贡献的概念，以促进本领域的技术发展，并且应被解释为不是要限制到这些具体引用的例子和条件。而且，本文陈述原理、方面以及本发明的各方面及其具体实施例的所有说明都旨在包括其结构上的和功能上的等同物。此外，其目的是，这种等同物包括现在已知的等同物以及将来发展的等同物，即，开发的执行相同功能的任何元件，而不论结构如何。因此，本发明的范围不被限制于本文所示出和描述的示例性的方面。而是，本发明的范围和精神由所附权利要求体现。

Claims (12)

1.一种用于为治疗装置提供指令的系统，所述系统包括：
可摄入的装置，其包括：
外壳；以及
输出模块，其被固定在所述外壳内以用于提供效应器指令；
其中所述可摄入的装置响应于期望事件的发生而在激活时向所述输出模块提供所述效应器指令；以及
响应器模块，其与所述治疗装置通信以用于接收和处理所述效应器指令，其中所述效应器指令改变所述治疗装置的至少一个操作。
2.如权利要求1所述的系统，其中所述外壳是密封的，并且其中所述可摄入的装置还包括固定在所述外壳内并与所述输出模块电耦接用于为所述输出模块供电的电源。
3.如权利要求1所述的系统，其中所述外壳在与期望靶位点的周围流体接触时溶解，以释放所述输出模块，并且其中所述输出模块包括：
支撑结构，其包括设置在所述支撑结构上的两种不同的材料，其中所述不同的材料表现出电势差，并且在与所述流体接触时为所述可摄入的装置供电；
密封的传导控制模块，其与所述不同的材料中的每一种电耦接，用于控制所述不同的材料之间的传导性，从而产生代表所述效应器指令的唯一的电流信号。
4.如权利要求3所述的系统，其中所述电流信号通过受控的离子发射来产生。
5.如权利要求1所述的系统，其中所述可摄入的装置还包括口服药物。
6.如权利要求1所述的系统，其中所述可摄入的装置还包括被固定在所述外壳内以提供第二效应器指令的第二输出模块。
7.如权利要求1所述的系统，其中所述响应器模块包括硬件部件和软件部件中的至少一种。
8.一种使用可摄入的装置为治疗装置提供指令的方法，所述方法包括以下步骤：
为所述可摄入的装置的效应器模块编程；
摄入所述可摄入的装置；
在到达靶位点时激活所述可摄入的装置，其中所述靶位点的特征在于存在导电流体；
通过所述效应器模块发送效应器指令；以及
通过与所述治疗装置相连的响应器模块接收和处理所述效应器指令，从而引起所述治疗装置的响应。
9.一种用于控制治疗递送的系统，该系统包括：
胶囊；
离子发射装置，其被设置在所述胶囊内以通过离子发射产生电流，其中所述离子发射模块包括一对材料，当被暴露到导电流体时，所述一对材料产生电势；
传导控制模块，其被设置在所述一对材料之间并且与所述一对材料电耦接，以用于控制传导性以产生携带效应器指令的唯一的电流信号。
10.如权利要求9所述的系统，还包括与治疗装置通信的响应器模块，其中所述响应器模块接收和处理所述效应器指令。
11.如权利要求10所述的系统，其中所述效应器指令改变所述治疗装置的至少一个操作。
12.如权利要求10所述的系统，其中所述一对材料由增加所述电流通路的不导电材料间隔开。
CN2009801496340A 2008-11-13 2009-11-13 可摄入的治疗激活器系统及方法 Expired - Fee Related CN102245259B (zh)

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US20120109112A1 (en) 2012-05-03
CN102245259B (zh) 2013-06-12
KR20110098719A (ko) 2011-09-01
CA2743781C (en) 2013-10-01
HK1161153A1 (en) 2012-08-24
IL212826A (en) 2015-09-24
KR101192690B1 (ko) 2012-10-19
EP2349445A2 (en) 2011-08-03
US8036748B2 (en) 2011-10-11
US20140180202A1 (en) 2014-06-26
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