CN102274555A - Quick-mixing preloaded medicine and solvent infusion combined device - Google Patents

Quick-mixing preloaded medicine and solvent infusion combined device Download PDF

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Publication number
CN102274555A
CN102274555A CN2010101946436A CN201010194643A CN102274555A CN 102274555 A CN102274555 A CN 102274555A CN 2010101946436 A CN2010101946436 A CN 2010101946436A CN 201010194643 A CN201010194643 A CN 201010194643A CN 102274555 A CN102274555 A CN 102274555A
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CN
China
Prior art keywords
puncture needle
medicine
bag
interface channel
parts
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Pending
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CN2010101946436A
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Chinese (zh)
Inventor
杨俊�
王�华
张静
吴锋
谷陟欣
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HUNAN KANGPU MEDICAL RESEARCH INSTITUTE
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HUNAN KANGPU MEDICAL RESEARCH INSTITUTE
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Priority to CN2010101946436A priority Critical patent/CN102274555A/en
Publication of CN102274555A publication Critical patent/CN102274555A/en
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Abstract

The invention discloses an infusion combined device (1), in which a loaded medicine and a solvent are separate during storage and completely mixed in use, and which is environment-friendly, easy to operate, low in cost and simple in process. The infusion combined device (1) comprises a medicine bag (3) in which the solvent is preloaded, a medicine container (4) having a supporting device, and a connecting part (2) which connects the medicine bag (3) and the medicine container (4). The connecting part (2) comprises a connecting channel which is positioned on the top part of the medicine bag; the medicine container is partially or completely positioned in the connecting channel (5); the support mouth part (4a) of the medicine container faces downward; a membrane (5a) is arranged in the connecting channel for blocking the channel before use; and a special puncture needle part (7) is positioned below the membrane (5a) in the connecting channel. When an external force is applied onto the puncture needle part through the medicine bag, the puncture needle (7a) penetrates the membrane and the medicine container support part; and thus, the medicine bag (3) and the medicine container (4) are communicated with each other.

Description

A kind of Prefilled and lysate transfusion composite set of rapid mixing
One, technical field
The present invention relates to a kind of infusion set, particularly relate to the intravenous drip transfusion composite set of medical application.
Two, background technology
Up to now, splendid attire in container (as vial, cast bottle) powdery medicine or medicament freeze-drying after powder, in medical institutions (as hospital), be used for intravenous drip after being dissolved into solution with lysate.Under normal conditions, powder charge container and the container of lysate is housed by realizing being communicated with such as two-way pin, connecting duct.The lysate that is used for dissolved substance is transferred to and contains medicine container, thus the wherein contained medicine of dissolving.
Yet aforesaid operations is complexity but also time-consuming not only, and even more serious is, punches containing on the medicine container for connection, directly contacts in the contained drug and atmosphere thereby make in the container, and there is contaminated danger in medicine.
In order to address the above problem, existing corresponding abroad infusion set occurs, as Japan Patent, and Publication No.61-501129 (with reference to U.S. Patent No. 4,583,971).
As shown in figure 11, this infusion set comprises a sealed compartment (102) that contains phial (101), a Bag for holding medicine that lysate is housed and has liquid outlet (103), and sealed compartment (102) is connected by conduit (104) with Bag for holding medicine (103).In conduit (104), phial one side has the pin (105) of a hollow, and Bag for holding medicine one side has a film (106), this film (106) has sealed conduit (104), has stoped flowing of liquid in the conduit.
Above-mentioned infusion set improves aspect being connected of medicine container and Bag for holding medicine containing.But dissolving step still is pretty troublesome because with the rubber stopper (108) of phial (101) and pin (105) near after, must be with hands with film (106) bending.And if film (106) is crooked insufficient, liquid just is difficult to by conduit (104), causes needs flower long time to come dissolved substance.In addition, the ingredient of this device is relatively big, causes cost than higher.
Three, summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned the deficiencies in the prior art, provides a kind of splendid attire medicine and lysate simultaneously, the pollution of avoiding dissolved outside to cause, reduce labor intensity, shorten the operating time, low production cost, the manufacturing process composite set of simply infusing.It can be contained in medicine and lysate in the same composite set, storage be both separately, can be fully during use, mix fast, making transfusion solution.
The present invention solves the problems of the technologies described above the employing following technical proposals.The transfusion composite set comprises the Bag for holding medicine of a dress lysate, the medicine container that contains with bracing or strutting arrangement, a link that connects Bag for holding medicine and contain medicine container.Wherein link comprises an interface channel, and this passage enters in the Bag for holding medicine through Bag for holding medicine top, contains the upper end that medicine container then partly or entirely is included in interface channel.Pastille receptacle support means opening down, a skim is in interface channel, blocked connection, the puncture needle parts are positioned at the film below, can in passage, slide, when external force when Bag for holding medicine exerts pressure for the puncture needle parts, pin can upwards slide, thorn rupture of membranes and pastille receptacle support means make to contain medicine container and Bag for holding medicine is interconnected.
Containing medicine container in this device is to link to each other by link with Bag for holding medicine, is blocked by a special film.A sting device is among interface channel, and by the promotion through Bag for holding medicine external force (axially or perpendicular to direction of principal axis), puncture needle passes film and pastille receptacle support means, realizes Bag for holding medicine and contains being interconnected between the medicine container.By these operations, medicine and lysate mix, and have generated the transfusion drug solution.
Key point of the present invention is by simply applying external force through Bag for holding medicine, impels the directed slip in puncture needle position, finishing transfusion preparation in the device of drug solution accurately.In this transfusion composite set, Bag for holding medicine and contain between the medicine container simply and very effectively to be communicated with and realized because the assembly that needs has reduced, has descended so cost is also corresponding in addition.
Four, description of drawings
Fig. 1 is a tangent plane sketch map of the embodiment of the invention 1 integral body;
Fig. 2 is the perspective view of puncture needle parts seen in fig. 1;
Fig. 3 is the another kind of vertical section sketch map of puncture needle parts seen in fig. 1;
Fig. 4 is a tangent plane sketch map of the embodiment of the invention 2 integral body;
Fig. 5 is the vertical section sketch map of puncture needle parts seen in fig. 4 and adjacent part;
Fig. 6 is the vertical section sketch map of second kind of puncture needle parts seen in fig. 4;
Fig. 7 is the vertical section sketch map of the third puncture needle parts seen in fig. 4;
Fig. 8 is the vertical section sketch map of the 4th kind of puncture needle parts seen in fig. 4;
Fig. 9 is the another kind of lancet and means vertical section sketch map that is different from puncture needle parts seen in fig. 4;
Figure 10 is another the lancet and means vertical section sketch map that is different from puncture needle parts seen in fig. 4;
Figure 11 is the front view of the infusion set of routine, and what part showed is sectional drawing.
Among the figure: 1, the transfusion composite set, 2, link, 3, Bag for holding medicine, 4, contain medicine container (phial), 4a, phial supports degree of lip-rounding parts, 5, interface channel, 5a, film, 5b, guide groove, 7, the puncture needle parts, 7a, puncture needle, 7b, disk, 7c, perforation, 7d, the space that supplies puncture needle in interface channel, to slide, 8, disk, 9, suspension member, 10, leakage fluid dram, 15, interface channel, 15a, film, 17, the puncture needle parts, 17a, puncture needle, 17b, the space that supplies puncture needle in interface channel, to slide, 17c, perforation, 17d, disk, 21, the transfusion composite set, 22, link, 23, Bag for holding medicine, 24, phial, 24a, phial supports degree of lip-rounding parts, 25 links, 25a, film, 27, the puncture needle parts, 27a, puncture needle, 27b, the elastomeric material assembly, 27c, button, 28, disk, 35, interface channel, 35a, film, 37, the puncture needle parts, 37a, puncture needle, 37b, the elastomeric material assembly, 37c, button, 45, interface channel, 45a, film, 47, the puncture needle parts, 47a, puncture needle, 47b, the elastomeric material assembly, 47c, button, 55, interface channel, 55a, film, 57, the puncture needle parts, 57a, puncture needle, 57b, the elastomeric material assembly, 57c, button, 65, interface channel, 65a, film, 67, the puncture needle parts, 67a, puncture needle, 67b, the inclined-plane, 68, button, 68a, the inclined-plane, 77, the puncture needle parts, 77a, puncture needle, 77d, tooth bar, 78, button, 78a, gear, 79, fulcrum, 101, phial, 102, sealed compartment, 103, Bag for holding medicine, 104, conduit, 105, puncture needle, 106, film, 107, suspension apparatus, 108, rubber stopper.
Five, the specific embodiment
To illustrate to introduce in detail the present invention by the integral body shown in Fig. 1 below.The content that this patent is protected not only is confined to the overall schematic listed.
In Fig. 1, transfusion composite set (1) comprises the Bag for holding medicine (3) that a soft material is made, wherein containing aseptic lysate, medicine bottle (following represent) (4) with phial, as a medicament reservoir, the sterile solid medicine is equipped with in the inside, and a link (2), makes phial and Bag for holding medicine to be interconnected.Just as shown in FIG. 1, phial partly is connected the upper end of interface channel (5), and phial supports degree of lip-rounding parts (4a) (Fig. 1 down; Here upwards identical with downward and follow-up description, the directivity among Fig. 1 concern that the back will continue to use).Designation number (9) refers to one by the made suspension member of soft polypropylene, and it is positioned at phial (4) top.Designation number (10) refers to the leakage fluid dram of Bag for holding medicine (3) bottom.
Bag for holding medicine is to be made by soft material, and as softish vinyl chloride resin, vistanex because these materials have good chemical inertness, seldom can react with lysate.
Be fit to be installed in the lysate in the above-mentioned Bag for holding medicine (3), use distilled water, and comprise multiple electrolytical solution as phosphate solution, 5% glucose solution, transfusion.
Phial (4) (body) is to be made by glass, and solid drugs is equipped with in the inside, and the opening of phial (4a) is supported thing and blocks, and does not show in the drawings.
Being fit to be installed in the above-mentioned medicine that contains in the medicine container (4) can be medicines such as antibiotic, antineoplastic agent and antiulcerative.
Wherein antibiotic can comprise cephalosporins, as cefazolin sodium, ceftizoxime, cefotiam/carpipramine, cefmenoxime, cefbuperazone, Cefodizime, cefonicid, cefpirome, ceftazidime, cefuroxime, cefamandole, cefmetazole, cefminox, ceforanide, cefotaxime, cefoxitin, ceftezole; Penicillin antibiotics is as sodium ampicillin, carbenicillin, sulbenicillin and ticarcillin; Antitumor drug comprises ametycin, fluorouracil, ftorafur and cytosine arabinoside; Antiulcer will comprise famotidine, ranitidine and cimetidine.
Link (2) comprises an interface channel (5), it enters Bag for holding medicine by the top of Bag for holding medicine (3), the phial bracing or strutting arrangement is comprised in the link upper end, also has a film (5a) in the interface channel, be used for closed channel, disk is placed on the film (5a) with the form of spacer, and the puncture needle parts (7) of a hollow are arranged under the film (5a), can slide along axle in interface channel (5).Disk (8) does not need to determine according to the configuration of phial (4) degree of lip-rounding part (4a) bracing or strutting arrangement.The assembling of above-mentioned parts is to carry out under aseptic condition.
As shown in Figure 2, puncture needle parts (7) comprise the slide block of a cylindrical base, the puncture needle of a hollow (7a).The bottom disc of slide block (7c) has segmental otch round puncture needle (7a).The internal diameter of cylindrical external diameter and interface channel (5) is consistent, and cylinder is fixed on the periphery of interface channel (5) along axle by the periphery that has vertical trench.
In Fig. 3, shown another kind of type puncture needle parts (17), it is different from the puncture needle parts (7) shown in Fig. 2, but can play a role in package unit equally.The puncture needle parts are hollow, the cylindrical configuration in two ends, and indication number (17a) refers to the puncture needle of a hollow, (17b) refers to a base plate, (17c) refers to a perforation.Space (17d) slides to film (15a) usefulness for puncture needle in interface channel (15).
In some cases, puncture needle parts (7) have plastics to make, because it can contact with the solvent in the Bag for holding medicine (3) like this.
Introduce below and how to use transfusion composite set described above.
Among Fig. 1, dress liquid bag (3) is from puncture needle parts (7) the summary upper/lower positions bending of end disc (7b) down.External force acts on to the disk (7b) of puncture needle (7) bottom through Bag for holding medicine (3).Then, puncture needle parts (7) slide to film (5a) direction in interface channel (5), thorn rupture of membranes (5a), disk (8) and phial (4) bracing or strutting arrangement, and so far Bag for holding medicine (3) has been realized being communicated with phial (4).By step extruding Bag for holding medicine (3), make that the puncture needle of lysate by hollow in the Bag for holding medicine flows to phial (4), reflux then, dissolve medicine in the phial (4) with this.Like this, just obtained the transfusion solution of standard in infusion set, this transfusion composite set has become phial (4) and has adorned the integral body that liquid bag (3) is interconnected this moment.
In sum, this transfusion composite set (1) has less assembly, and is relatively more cheap, makes the preparation transfusion can pass through crooked Bag for holding medicine (3), presses puncture needle parts (7), realizes easily in the short period of time.
In Fig. 4, indication number (21) refers to a transfusion composite set, (22) refer to a link, (23) refer to Bag for holding medicine (container of soft material), (25) refer to an interface channel, (25a) refer to a film, (27) refer to the puncture needle parts, and (28) refer to disk.In the overall diagram of Fig. 4, phial (24) have it support degree of lip-rounding parts (24a) (such as, ventricumbent degree of lip-rounding parts (24a) are sealed by a support membrane that does not show), this part is completely contained in the interface channel (25).
Puncture needle parts (27) comprise a hollow needle (27a), by the assembly that is used to change direction that elastomeric material (27b) is made, the button (27c) perpendicular to interface channel (25) axis.Interface channel (25) is used to allow the puncture needle parts slide inside.In Fig. 5, shown the vertical cross section of the needle part that is in installment state.
In use, external force is applied on the button (27c) by Bag for holding medicine (23).Then, pin (27a) just slides in interface channel (25) by elastomeric material assembly (27b), thorn rupture of membranes (25a), disk (28) and phial (24) bracing or strutting arrangement.So far, the inner and inner realization connection of phial (24) of Bag for holding medicine (23).
In Fig. 6-10, shown the vertical cross section of several puncture needle parts that can in whole infusion set shown in Figure 4, use in addition.
In Fig. 6, by pressing the button (37c) on the puncture needle parts (37), hollow needle (37a) is implemented in the interface channel (35) by elastomeric material (37b) and slides.Spike pierces film (35a), disk and phial bracing or strutting arrangement (both is not shown in the diagram).The overall diagram that shows in Fig. 7 and Fig. 8 has similar structure and similar effect.
Puncture needle parts (67) utilize the inclined-plane as a device that changes direction in Fig. 9 overall diagram.Pin of hollow (67a) and button are placed in inclined-plane (68b), (68a) part respectively, and in vertical part, both realize being connected.When button (68) is pressed, pin (67a) just under the effect on inclined-plane, slides in interface channel (65), then stings rupture of membranes (65a).
Puncture needle parts (77) utilize gear as a device that changes direction in Figure 10 overall diagram.The pin of hollow (77a) has tooth bar (77b), and button (78) is partly with gear (78a), the rack and pinion combination that interlocks.When button (78) is pressed, gear (78a) serves as that axle is rotated with fulcrum (79), and pin (77a) just under the effect of the friendship of gear and tooth bar, upwards slides, and then stings rupture of membranes (not demonstration among the figure).
In this device, containing medicine container and Bag for holding medicine can simply realize by press the puncture needle parts from Bag for holding medicine.Therefore, Chang Gui infusion set relatively, that the connection between this apparatus container seems is convenient, actively, simultaneously required parts, cost are still less.

Claims (10)

1. transfusion composite set is characterized in that comprising that Bag for holding medicine that a soft material that fills lysate makes, one contain medicine container and one and be used to be communicated with the link that contains medicine container and Bag for holding medicine.
2. require the 1 described medicine container that contains according to patent, its feature contains a degree of lip-rounding position that has bracing or strutting arrangement, there is a film at this degree of lip-rounding position down in the interface channel, be used for closed channel, puncture needle parts are arranged under the film, can be in interface channel axially slide, thus when an external force when Bag for holding medicine affacts on the puncture needle parts, puncture needle can slip vertically in interface channel, thorn rupture of membranes, pastille receptacle support means realize containing being interconnected of medicine container and Bag for holding medicine.
3. require 1 described link according to patent, its feature comprises the interface channel that is connected to through Bag for holding medicine top in the Bag for holding medicine, powder charge container part or all be included in the interface channel.
4. according to the puncture needle described in the claim 2, be characterized in and in interface channel, slide along axle, as external force when Bag for holding medicine affacts the puncture needle feature bottom, puncture needle parts integral body is slided vertically, the spike pierces film of its top and pastille receptacle support means, thus realize containing being interconnected of medicine container and Bag for holding medicine.
5. according to the puncture needle parts described in the claim 2, its feature comprises the pin of a hollow, a button, the direction modifier between pin and button, when the external force edge affacts on the button perpendicular to the interface channel direction of principal axis, through the effect of direction modifier, puncture needle slides in interface channel vertically, the thorn rupture of membranes makes to contain medicine container and Bag for holding medicine is interconnected.
6. puncture needle parts described in the claim 2, its feature comprises an energy at the button that moves perpendicular to the puncture needle glide direction, this device can be with the mobile puncture part that is delivered to of button, thereby realizes the interlock of puncture needle and button.
7. require 3 described interface channels according to patent, be characterized in comprising that containing medicine container links to each other with the top of link, Open Side Down, and a film is arranged in the interface channel, is used for closed channel, a puncture needle is arranged under the film, can slide along axle in interface channel, when Bag for holding medicine affacted on the puncture needle parts, the puncture needle parts upwards slided as external force, the spike pierces film makes to contain medicine container and Bag for holding medicine is realized being interconnected.
8. require 3 described links according to patent, its characteristics are made up of two parts, part 1 comprises described the part or all of of medicine container that contain, being called for short part 2 extends in the Bag for holding medicine, be characterized in that the puncture needle parts are in the link part 2, can slide therein, comprise a puncture part, puncture needle parts in the link part 2 can slide on the approach that comprises link part 1, and the puncture part partly has the space to separate with the degree of lip-rounding that contains medicine container.
9. require 8 described links according to patent, its characteristics also comprise the support component of sting device through the degree of lip-rounding part of band bracing or strutting arrangement, and be in film between part 1 and the part 2 in the link, when needle part is in link part 1, there is the space to separate between bracing or strutting arrangement and the film, film is between bracing or strutting arrangement and the puncture needle part, and the puncture needle parts are in 2 expression punctures of link part part and have stung rupture of membranes.
10. require the 1 described medicine container that contains according to patent, its feature comprises a degree of lip-rounding parts that have bracing or strutting arrangement, before these parts are in the described communication means part 1.
CN2010101946436A 2010-06-08 2010-06-08 Quick-mixing preloaded medicine and solvent infusion combined device Pending CN102274555A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103156772A (en) * 2013-04-07 2013-06-19 上海武彬包装制品有限公司 Transfusion container and manufacturing method thereof
CN105078749A (en) * 2015-09-25 2015-11-25 四川科伦药业股份有限公司 Polypropylene infusion bag with buffering function
CN110239804A (en) * 2019-07-17 2019-09-17 东莞博识生物科技有限公司 Lancing device and microfluidic device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308347A (en) * 1991-09-18 1994-05-03 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
US5352191A (en) * 1991-10-25 1994-10-04 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
US5380315A (en) * 1992-02-04 1995-01-10 Material Engineering Technology Laboratory Incorporated Mixing apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308347A (en) * 1991-09-18 1994-05-03 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
US5352191A (en) * 1991-10-25 1994-10-04 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
US5380315A (en) * 1992-02-04 1995-01-10 Material Engineering Technology Laboratory Incorporated Mixing apparatus

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103156772A (en) * 2013-04-07 2013-06-19 上海武彬包装制品有限公司 Transfusion container and manufacturing method thereof
CN103156772B (en) * 2013-04-07 2015-11-18 上海武彬包装制品有限公司 A kind of infusion vessel and production method thereof
CN105078749A (en) * 2015-09-25 2015-11-25 四川科伦药业股份有限公司 Polypropylene infusion bag with buffering function
CN110239804A (en) * 2019-07-17 2019-09-17 东莞博识生物科技有限公司 Lancing device and microfluidic device

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Application publication date: 20111214