CN102305818A - Measuring system for electrochemical biosensor - Google Patents
Measuring system for electrochemical biosensor Download PDFInfo
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- CN102305818A CN102305818A CN201110247432A CN201110247432A CN102305818A CN 102305818 A CN102305818 A CN 102305818A CN 201110247432 A CN201110247432 A CN 201110247432A CN 201110247432 A CN201110247432 A CN 201110247432A CN 102305818 A CN102305818 A CN 102305818A
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Abstract
The invention discloses a measuring system for an electrochemical biosensor. The measuring system comprises a microcontroller and a test paper strip slot, wherein the test paper strip slot is connected with a test paper strip identification circuit for identifying different sensor test paper strip types, an operating voltage generating circuit for generating operating voltage required by electrochemical reaction and a current/voltage conversion circuit for converting current of an operating electrode of a sensor test paper strip into voltage; the test paper strip identification circuit is connected to the microcontroller; the current/voltage conversion circuit is connected with a signal processing circuit; the signal processing circuit is connected with an analog-digital converter; the analog-digital converter is connected with the microcontroller; and the microcontroller is connected with a display and a key. By the measuring system, the higher current gain can be realized by using a resistor with conventional resistance, the regulation range of the gain is wider, the function expansion and high performance of the sensor can be adapted, and the power consumption of the system is controlled to a low level.
Description
Technical field
The invention belongs to the technical field of electrochemica biological sample detection, relate to a kind of can be to some biochemical indicator blood sugar, cholesterol electrochemical biosensor measuring system of carrying out quantitative test for example.
Background technology
Fig. 1 illustrates, and the spy opens the formation of disclosed existing blood-sugar value measuring device in the flat 11-174022 communique.Existing blood glucose measuring device is made up of switch 1, electrochemical sensor 2, sensor amplifier 3, feedback resistance 4, voltage, integral analogue-to-digital converter.Be connected to earth potential Vss with the anodal or suitable lower electrode of negative pole of electrochemical sensor 2 through switch 1, the upper electrode that is equivalent to negative pole or positive pole is connected with sensor amplifier 3.Sensor amplifier 3 another input end input service voltage Vsg.Connect feedback resistance 4 between the sensor amplifier I/O.The aanalogvoltage Vdata of the output of sensor amplifier 3 converts electric current to by voltage-current converter circuit, then, converts digital signal to by integral analogue-to-digital converter.
Its course of work is following:
On the upper electrode of electrochemical sensor 2, apply voltage V0, on lower electrode, apply voltage Vss, flow through electric current I a between two electrodes.Ia produces voltage drop Va=Ia * R0 on feedback resistance 4.The output voltage of sensor amplifier 3 is Vdata=Va+Vsg.Voltage Vdata converts electric current to by voltage-current converter circuit, then carries out analog to digital conversion by integrated AD C32, exports as digital signal.Digital signal is handled by the circuit of back, expresses blood glucose value.
In existing blood glucose measuring device, reading of electric current is to realize through feedback resistance shown in Figure 1 14.Usually the electrochemical reaction current value is less, for assurance has enough sensitivity, analog to digital converter input enough dynamic ranges is arranged, and the feedback resistance of big resistance often need be set, even may require unrealistic big resistance.Only if adopt suitable circuit to make measure, otherwise the on every side medium resistance parallelly connected with feedback resistance will make clean feedback resistance reduce, and the accuracy of circuit is incurred loss.
In addition, the function that also requires measurement mechanism can adapt to sensor expands and high performance, for example: the improvement and the progress of the enzyme that many index measurements of indexs such as compatible cholesterol and sensor use.This just requires measurement mechanism can discern the different sensor type, and adjusts the amplitude and the polarity of operating voltage according to the sensor type self-adaptation.
Simultaneously, this type measurement mechanism often need be realized miniaturization, adopts powered battery more, and the power problems of system is the emphasis that needs are paid close attention to.
Summary of the invention
For overcoming deficiency of the prior art; The object of the present invention is to provide and a kind ofly can use conventional resistance resistance to realize higher current gain; And gain-adjusted wider range; The function that can adapt to sensor expands and high performance; The simultaneity factor power consumption control makes measuring system realize with low cost, advantage of high precision at the electrochemical biosensor measuring system of a reduced levels simultaneously.
For realizing above-mentioned technical purpose, reach above-mentioned technique effect, the present invention has adopted following technical scheme:
A kind of electrochemical biosensor measuring system; Comprise a microcontroller; Also comprise a test strips draw-in groove; Said test strips draw-in groove is connected with the current/voltage-converted circuit that working volt produce circuit and that a test strips identification circuit, that is used to discern different sensor test strips type is used to produce the required operating voltage of electrochemical reaction is used for the current conversion on the sensor test strips working electrode is become voltage respectively; Said test strips identification circuit is connected to said microcontroller; Said current/voltage-converted circuit connects a signal processing circuit; Said signal processing circuit connects an analog-digital converter; Said analog-digital converter connects said microcontroller, and said microcontroller is connected with display and button.
Further, said analog to digital converter is connected with a temperature sensing circuit.
Further, said test strips identification circuit can be discerned different sensor test strips type.
Further, said test strips identification circuit is discerned different sensor test strips type through the resistance of conductive layer on the identification test strips.
Further, said working volt produce circuit can self-adaptation the operating voltage of adjustment electrochemical reaction.
Further, operating voltage polarity, the amplitude of said working volt produce circuit generation are all adjustable.
Further, said working volt produce circuit mainly is made up of digital to analog converter and analog switch.
Further, said current/voltage-converted circuit uses the feedback resistance of conventional resistance can realize high sensitivity.
Further, said current/voltage-converted circuit is the high sensitivity current/voltage-converted circuit that T type network constitutes.
Further, microcontroller and other device are low energy-consumption electronic device.
Further, microcontroller is in the park mode of low-power consumption at ordinary times, wakes its device when needing work up and gets into mode of operation.
Compared with prior art, the present invention has following beneficial effect:
The present invention is through to the measurement of test strips resistance conductive layer, type that can automatic identification sensor; Adopted digital to analog converter, analog switch etc. to constitute working volt produce circuit, operating voltage can realize the adjustment of polarity, and the amplitude in the certain limit adjusts continuously, and the function that can adapt to sensor expands and high performance; The high sensitivity current/voltage-converted circuit that has adopted T type network to realize can use conventional resistance resistance to realize higher current gain, and gain-adjusted wider range; Because the employing of low energy-consumption electronic device, and the setting of working method, system power dissipation is controlled at a lower level.
Above-mentioned explanation only is the general introduction of technical scheme of the present invention, to understand technological means of the present invention in order can more knowing, and can to implement according to the content of instructions, below with preferred embodiment of the present invention and conjunction with figs. describe in detail as after.
Description of drawings
Accompanying drawing described herein is used to provide further understanding of the present invention, constitutes the application's a part, and illustrative examples of the present invention and explanation thereof are used to explain the present invention, do not constitute improper qualification of the present invention.In the accompanying drawings:
Fig. 1 is existing blood glucose measuring device schematic diagram.
The electrochemica biological sensor test strips structural drawing that Fig. 2 is suitable for for the present invention.
Fig. 3 is and electrochemical biosensor measuring system of the present invention.
Fig. 4 is the electrochemica biological sensor measurement mechanism test strips identification circuit schematic diagram relevant with an embodiment of the present invention.
Fig. 5 is electrochemica biological sensor measurement mechanism operating voltage generation circuit and the current/voltage-converted circuit theory diagrams relevant with an embodiment of the present invention.
Embodiment
Below with reference to the accompanying drawings and combine embodiment, describe the present invention in detail.
Referring to shown in Figure 2; A kind of sensor test strips 20 is disclosed; Said sensor test strips 20 has contrast electrode parallel to each other on dielectric base 21, first working electrode 23 and second working electrode 25, and on they are electric and reference contact 22, first contact 24 and second contact 26 is interconnected; Also have structures such as conductive layer 27 simultaneously.The resistance of dissimilar electrochemica biological sensor conductive layers 27 is different.The reactant of fixing above the electrode through reacting with the sample material that adds, produces corresponding to specific electric charge to be measured.
Referring to shown in Figure 3; Electrochemical biosensor measuring system of the present invention comprises a microcontroller 110; Also comprise a test strips draw-in groove 101; Said test strips draw-in groove 101 is connected with the current/voltage-converted circuit 104 that working volt produce circuit 103 and that a test strips identification circuit 102, that is used to discern different sensor test strips type is used to produce the required operating voltage of electrochemical reaction is used for the current conversion on the sensor test strips working electrode is become voltage respectively; Said test strips identification circuit 102 is connected to said microcontroller 110; Said current/voltage-converted circuit 104 connects a signal processing circuit 105; Said signal processing circuit 105 connects an analog-digital converter 106; Said analog-digital converter 106 connects said microcontroller 110, and said microcontroller 110 is connected with display apparatus module 108 and key-press module 109.
Further, said analog to digital converter 106 is connected with a temperature sensing circuit 107.
Realize being electrically connected of reference contact 22, first contact 24, second contact 26 and 27 liang of terminal contacts of conductive layer and electrochemica biological sensor measurement mechanism on the sensor test strips 20 through test strips draw-in groove 101; When test strips is inserted the test strips draw-in groove, two electrodes on the conductive layer 27 conducting test strips draw-in grooves, the guiding measuring device gets into measurement pattern; Measure the resistance of conductive layer simultaneously, discern the type of electrochemica biological sensor; Working volt produce circuit utilizes the operating voltage of device polarizations such as digital to analog converter, analog switch and operational amplifier, variable-magnitude, to be applicable to dissimilar test strips; Applied operating voltage; After sample to be tested adds; Have the electric current that flows through first working electrode 23, second working electrode 25; For being linear positively related voltage signal with it, the current/voltage-converted circuit is the high sensitivity current/voltage-converted circuit that T type network is realized to the current/voltage-converted circuit with this current conversion; The voltage signal of current/voltage-converted circuit output amplifies, is input to after the processing such as denoising the input end of analog to digital converter through signal processing circuit; Analog to digital converter converts the aanalogvoltage of signal processing circuit input to digital quantity, and this digital quantity has been represented the size that flows through the working electrode electric current; Microcontroller reads analog-to-digital result, after doing denoising, correction etc. and handling, calculates concentration to be measured, and concentration and relevant information are presented on the display; Button is used for the setting of parameter, result's functions such as inquiry; The temperature sensing circuit detected temperatures, the temperature coefficient that is used for testing result is proofreaied and correct; System's microcontroller and other device all adopt low energy-consumption electronic device; Insertion and button operation by test strips wake microcontroller entering duty up, are in dormant state in other most times, and cut off the power supply of other circuit.
In this embodiment, microcontroller 110 is selected super low-power consumption microcontroller MSP430.
Below, the operation of the electrochemical biosensor measuring system relevant with this embodiment is described.
At first sensor test strips 20 is inserted in the test strips draw-in groove 101.Sensor test strips 20 be inserted through the effect that test strips identification circuit 102 plays two aspects: wake microcontroller 110 up and get into mode of operations; Bleeder circuit output is simultaneously come the type of identification sensor test strips 20 corresponding to the aanalogvoltage of different test strips conductive layer 27 resistance by microcontroller 110.
Fig. 4 shows the schematic diagram of test strips identification circuit.Conductive layer 27 on the sensor test strips 20 is the resistance 201 formation bleeder circuits of R1 with resistance.Let the resistance of the conductive layer is Rx, then A0, P1.0 point potential
.Adjust the value of R1, so that
MSP430 less than the maximum low-level input voltage.Therefore, the insertion meeting of sensor test strips 20 is in negative edge skip signal of the P1.0 of MSP430 pin input, and the P1.0 port has interrupt function, wakes MSP430 up and gets into mode of operation.Simultaneously, this current potential is input to the inner ADC input end of MSP430 A0, draws the value of this current potential, and then estimate conductive layer 27 resistance Rx, discern the sensors of various types test strips.
Fig. 5 shows the current/voltage-converted circuit theory diagrams of operating voltage generation circuit and T type network formation.
After identifying sensor type, measurement mechanism self-adaptation adjustment operating voltage.MSP430 pin P2.0 control analog switch S1 switches the current potential of contrast electrode 21 between Vss and 2.5V.The in-phase end of amplifier 41,42 is received in the inner integrated digital to analog converter DAC1 of MSP430, the output of DAC0; Characteristic according to the high gain operational amplifier imaginary short; End of oppisite phase voltage is identical with in-phase end, so the voltage of first working electrode 23, second working electrode 25 is the output voltage of DAC1, DAC0.Digital to analog converter is 12 word lengths, and getting reference voltage is 2.5V.Operating voltage is the potential difference (PD) of working electrode and contrast electrode.In sum, the range of adjustment of operating voltage is 0～± 2.5V, resolution is 0.61mV.
After applying operating voltage, adding detection sample, corresponding composition generation chemical reaction in enzyme in the sensor and the sample has with the corresponding electric current I a1 of constituent concentration to be measured, Ia2 and flows through working electrode.Ia1, Ia2 become aanalogvoltage Vdata1, Vdata2 through the current/voltage-converted circuit conversion.
Circuit utilizes a kind of T type network to realize high sensitivity and the unrealistic big resistance of demand not among Fig. 5.In order to eliminate the issuable vibration of amplifier, and introduce resistance R 44, R54, its resistance is very little, can ignore.If two digital to analog converter output voltages are respectively VDAC1, VDAC0.
This circuit improves gain by multiplication factor, can multiply by needed multiplication factor then and realize high sensitivity from a rational feedback resistance like this.
The output of current/voltage-converted circuit promptly behind the low-pass first order filter, is input to the inner integrated analog to digital converter input end of MSP430 through signal processing circuit, and analog signal conversion is become digital quantity, calculates concentration value to be measured.
Temperature sensing circuit testing environment temperature is set, proofreaies and correct testing result is carried out temperature coefficient.The temperature sensor TMP20 of temperature sensor working voltage output type.
Information such as measurement result are shown on the display 108, and the display 108 that adopts in this embodiment is MOBI2006.
Key-press module 109 is used for the setting of parameter, the operations such as inquiry of measurement result.
MSP430 is in the LPM3 low-power consumption mode usually, and the control signal of its output is simultaneously cut off the power supply of other partial circuit through the control analog switch.When test strips is inserted or button operation is arranged, get into and interrupt waking up its entering AM mode of operation.The power consumption of system has been controlled in lower level like this.
The above is the preferred embodiments of the present invention only, is not limited to the present invention, and for a person skilled in the art, the present invention can have various changes and variation.All within spirit of the present invention and principle, any modification of being done, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. electrochemical biosensor measuring system; Comprise a microcontroller (110); It is characterized in that: also comprise a test strips draw-in groove (101); Said test strips draw-in groove (101) is connected with the current/voltage-converted circuit (104) that working volt produce circuit (103) and that a test strips identification circuit (102), that is used to discern different sensor test strips type is used to produce the required operating voltage of electrochemical reaction is used for the current conversion on the sensor test strips working electrode is become voltage respectively; Said test strips identification circuit (102) is connected to said microcontroller (110); Said current/voltage-converted circuit (104) connects a signal processing circuit (105); Said signal processing circuit (105) connects an analog-digital converter (106); Said analog-digital converter (106) connects said microcontroller (110), and said microcontroller (110) is connected with display (108) and button (109).
2. electrochemical biosensor measuring system according to claim 1 is characterized in that: said analog to digital converter (106) is connected with a temperature sensing circuit (107).
3. electrochemical biosensor measuring system according to claim 1 is characterized in that: said test strips identification circuit (102) is discerned different test strips types through the resistance of the resistance implanted on the test strip.
4. electrochemical biosensor measuring system according to claim 1 is characterized in that: said working volt produce circuit (103) can be according to the test strips type, the polarity and the amplitude of self-adaptation adjustment operating voltage.
5. electrochemical biosensor measuring system according to claim 1 is characterized in that: said working volt produce circuit (103) comprises that mainly digital to analog converter, analog switch are as its building block.
6. electrochemical biosensor measuring system according to claim 1 is characterized in that: said current/voltage-converted circuit (104) uses the feedback resistance of conventional resistance can realize the high sensitivity of current gain.
7. electrochemical biosensor measuring system according to claim 1 is characterized in that: the high sensitivity current/voltage-converted circuit that said current/voltage-converted circuit (104) constitutes for T type network.
8. electrochemica biological sensor measurement mechanism according to claim 1 is characterized in that: said microcontroller (110) is in park mode at ordinary times, wakes it when needing work up and gets into mode of operation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110247432A CN102305818A (en) | 2011-08-24 | 2011-08-24 | Measuring system for electrochemical biosensor |
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| CN201110247432A CN102305818A (en) | 2011-08-24 | 2011-08-24 | Measuring system for electrochemical biosensor |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106338596A (en) * | 2016-08-24 | 2017-01-18 | 四川长虹通信科技有限公司 | Health monitoring method, health monitoring apparatus, and electronic equipment |
| CN108872322A (en) * | 2018-08-22 | 2018-11-23 | 江苏鱼跃医疗设备股份有限公司 | With can automatic identification distinguish information test paper |
| CN111208175A (en) * | 2020-01-10 | 2020-05-29 | 三诺生物传感股份有限公司 | Sensor identification method and device and object to be tested test equipment |
| WO2021244276A1 (en) * | 2020-05-30 | 2021-12-09 | 杭州安旭生物科技股份有限公司 | Multi-detection item test device and method |
| CN114778631A (en) * | 2022-06-17 | 2022-07-22 | 北京华益精点生物技术有限公司 | Body index detection device and method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1419651A (en) * | 2000-03-22 | 2003-05-21 | 全麦迪科斯有限责任公司 | Electrochemical biosensor test strip with recognition electrode and readout meter using this test strip |
| CN2890916Y (en) * | 2005-09-30 | 2007-04-18 | 合世生医科技股份有限公司 | Biosensor test piece with recognition function and sensor matching therewith |
| US20080112852A1 (en) * | 2002-04-25 | 2008-05-15 | Neel Gary T | Test Strips and System for Measuring Analyte Levels in a Fluid Sample |
| US20090101500A1 (en) * | 2007-10-19 | 2009-04-23 | Tien-Tsai Hsu | Test strip with identification function and test instrument using the same |
| CN101661015A (en) * | 2009-09-09 | 2010-03-03 | 上海睿兴实业有限公司 | Universal portable detector for electrochemical biosensor |
-
2011
- 2011-08-24 CN CN201110247432A patent/CN102305818A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1419651A (en) * | 2000-03-22 | 2003-05-21 | 全麦迪科斯有限责任公司 | Electrochemical biosensor test strip with recognition electrode and readout meter using this test strip |
| US20080112852A1 (en) * | 2002-04-25 | 2008-05-15 | Neel Gary T | Test Strips and System for Measuring Analyte Levels in a Fluid Sample |
| CN2890916Y (en) * | 2005-09-30 | 2007-04-18 | 合世生医科技股份有限公司 | Biosensor test piece with recognition function and sensor matching therewith |
| US20090101500A1 (en) * | 2007-10-19 | 2009-04-23 | Tien-Tsai Hsu | Test strip with identification function and test instrument using the same |
| CN101661015A (en) * | 2009-09-09 | 2010-03-03 | 上海睿兴实业有限公司 | Universal portable detector for electrochemical biosensor |
Non-Patent Citations (1)
| Title |
|---|
| 佘乾顺: "微弱电流检测系统的设计与实现", 《中国优秀硕士学位论文全文数据库 信息科技辑》, no. 06, 15 June 2010 (2010-06-15) * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106338596A (en) * | 2016-08-24 | 2017-01-18 | 四川长虹通信科技有限公司 | Health monitoring method, health monitoring apparatus, and electronic equipment |
| CN108872322A (en) * | 2018-08-22 | 2018-11-23 | 江苏鱼跃医疗设备股份有限公司 | With can automatic identification distinguish information test paper |
| CN111208175A (en) * | 2020-01-10 | 2020-05-29 | 三诺生物传感股份有限公司 | Sensor identification method and device and object to be tested test equipment |
| WO2021244276A1 (en) * | 2020-05-30 | 2021-12-09 | 杭州安旭生物科技股份有限公司 | Multi-detection item test device and method |
| CN114778631A (en) * | 2022-06-17 | 2022-07-22 | 北京华益精点生物技术有限公司 | Body index detection device and method |
| CN114778631B (en) * | 2022-06-17 | 2022-12-02 | 北京华益精点生物技术有限公司 | Body index detection device and method |
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Application publication date: 20120104 |