CN102379684B - 药物信息系统 - Google Patents
药物信息系统 Download PDFInfo
- Publication number
- CN102379684B CN102379684B CN201110212586.4A CN201110212586A CN102379684B CN 102379684 B CN102379684 B CN 102379684B CN 201110212586 A CN201110212586 A CN 201110212586A CN 102379684 B CN102379684 B CN 102379684B
- Authority
- CN
- China
- Prior art keywords
- signal
- circuit
- certain embodiments
- evaluator
- electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000001514 detection method Methods 0.000 claims abstract description 35
- 239000000463 material Substances 0.000 claims description 84
- 230000005540 biological transmission Effects 0.000 claims description 25
- 239000012530 fluid Substances 0.000 claims description 24
- 238000010168 coupling process Methods 0.000 claims description 21
- 238000005859 coupling reaction Methods 0.000 claims description 21
- 230000008878 coupling Effects 0.000 claims description 20
- 238000004891 communication Methods 0.000 claims description 18
- 230000004913 activation Effects 0.000 claims description 17
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 11
- 229910052710 silicon Inorganic materials 0.000 claims description 11
- 239000010703 silicon Substances 0.000 claims description 11
- 239000002552 dosage form Substances 0.000 claims description 8
- 230000008021 deposition Effects 0.000 claims description 7
- 230000008093 supporting effect Effects 0.000 claims description 5
- 150000002500 ions Chemical class 0.000 claims description 4
- 239000011343 solid material Substances 0.000 claims 2
- 230000003447 ipsilateral effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 124
- 238000000034 method Methods 0.000 abstract description 96
- 238000012544 monitoring process Methods 0.000 abstract description 20
- 239000008177 pharmaceutical agent Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 238000011285 therapeutic regimen Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 166
- 239000006187 pill Substances 0.000 description 104
- 238000002360 preparation method Methods 0.000 description 80
- 229910052751 metal Inorganic materials 0.000 description 68
- 239000002184 metal Substances 0.000 description 68
- 239000003795 chemical substances by application Substances 0.000 description 56
- 229940079593 drug Drugs 0.000 description 55
- 230000003213 activating effect Effects 0.000 description 54
- 230000008859 change Effects 0.000 description 41
- 239000003826 tablet Substances 0.000 description 37
- 210000002784 stomach Anatomy 0.000 description 36
- 238000011282 treatment Methods 0.000 description 33
- 150000001875 compounds Chemical class 0.000 description 30
- 238000012360 testing method Methods 0.000 description 27
- 102000005962 receptors Human genes 0.000 description 26
- 108020003175 receptors Proteins 0.000 description 26
- 239000000243 solution Substances 0.000 description 25
- 230000000694 effects Effects 0.000 description 24
- 238000005516 engineering process Methods 0.000 description 24
- 230000001225 therapeutic effect Effects 0.000 description 24
- -1 Cycloxygenase Proteins 0.000 description 21
- 239000003792 electrolyte Substances 0.000 description 21
- 241001597008 Nomeidae Species 0.000 description 20
- 201000010099 disease Diseases 0.000 description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 19
- 239000000126 substance Substances 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 17
- 238000013461 design Methods 0.000 description 17
- 238000006243 chemical reaction Methods 0.000 description 15
- 230000008569 process Effects 0.000 description 15
- 230000000875 corresponding effect Effects 0.000 description 14
- 230000006870 function Effects 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 13
- 239000002775 capsule Substances 0.000 description 13
- 239000010949 copper Substances 0.000 description 13
- 239000011777 magnesium Substances 0.000 description 13
- 235000002639 sodium chloride Nutrition 0.000 description 13
- 229960002003 hydrochlorothiazide Drugs 0.000 description 12
- 239000010410 layer Substances 0.000 description 12
- 230000004044 response Effects 0.000 description 12
- 239000003990 capacitor Substances 0.000 description 11
- 230000000747 cardiac effect Effects 0.000 description 11
- 230000005611 electricity Effects 0.000 description 11
- 239000000758 substrate Substances 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
- DOQPXTMNIUCOSY-UHFFFAOYSA-N [4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-[2-(3,4-dimethoxyphenyl)ethyl]-methylazanium;chloride Chemical compound [H+].[Cl-].C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 DOQPXTMNIUCOSY-UHFFFAOYSA-N 0.000 description 10
- 239000004020 conductor Substances 0.000 description 10
- 238000010586 diagram Methods 0.000 description 10
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 10
- 239000007772 electrode material Substances 0.000 description 10
- 238000009434 installation Methods 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 238000011160 research Methods 0.000 description 10
- 230000008054 signal transmission Effects 0.000 description 10
- 238000003860 storage Methods 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- 229940088598 enzyme Drugs 0.000 description 9
- 210000004051 gastric juice Anatomy 0.000 description 9
- 150000002739 metals Chemical class 0.000 description 9
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 9
- 238000012545 processing Methods 0.000 description 9
- 210000001124 body fluid Anatomy 0.000 description 8
- 239000010839 body fluid Substances 0.000 description 8
- 239000002327 cardiovascular agent Substances 0.000 description 8
- 229940125692 cardiovascular agent Drugs 0.000 description 8
- 239000004567 concrete Substances 0.000 description 8
- 239000007943 implant Substances 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 239000004065 semiconductor Substances 0.000 description 8
- 238000012546 transfer Methods 0.000 description 8
- 230000000202 analgesic effect Effects 0.000 description 7
- 230000036772 blood pressure Effects 0.000 description 7
- 239000000599 controlled substance Substances 0.000 description 7
- 238000000151 deposition Methods 0.000 description 7
- 230000036541 health Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000035479 physiological effects, processes and functions Effects 0.000 description 7
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 7
- 230000011514 reflex Effects 0.000 description 7
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 6
- 229940097420 Diuretic Drugs 0.000 description 6
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 6
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 6
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 6
- 230000000712 assembly Effects 0.000 description 6
- 238000000429 assembly Methods 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 229940125368 controlled substance Drugs 0.000 description 6
- 229910052802 copper Inorganic materials 0.000 description 6
- 239000002934 diuretic Substances 0.000 description 6
- 230000001882 diuretic effect Effects 0.000 description 6
- 238000001647 drug administration Methods 0.000 description 6
- 239000003937 drug carrier Substances 0.000 description 6
- 229920000159 gelatin Polymers 0.000 description 6
- 235000019322 gelatine Nutrition 0.000 description 6
- 230000001976 improved effect Effects 0.000 description 6
- 229910052749 magnesium Inorganic materials 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- 230000010355 oscillation Effects 0.000 description 6
- 230000036407 pain Effects 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 230000001105 regulatory effect Effects 0.000 description 6
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 5
- 108010010803 Gelatin Proteins 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- 229930006000 Sucrose Natural products 0.000 description 5
- RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 5
- 239000010405 anode material Substances 0.000 description 5
- 230000004888 barrier function Effects 0.000 description 5
- JIVPVXMEBJLZRO-UHFFFAOYSA-N chlorthalidone Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C2(O)C3=CC=CC=C3C(=O)N2)=C1 JIVPVXMEBJLZRO-UHFFFAOYSA-N 0.000 description 5
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 5
- 230000029087 digestion Effects 0.000 description 5
- 229960005156 digoxin Drugs 0.000 description 5
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 5
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 description 5
- 230000037406 food intake Effects 0.000 description 5
- 230000002496 gastric effect Effects 0.000 description 5
- 239000008273 gelatin Substances 0.000 description 5
- 229940014259 gelatin Drugs 0.000 description 5
- 235000011852 gelatine desserts Nutrition 0.000 description 5
- 239000010931 gold Substances 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 238000005240 physical vapour deposition Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 238000007789 sealing Methods 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- 229960004793 sucrose Drugs 0.000 description 5
- 239000000829 suppository Substances 0.000 description 5
- 238000004448 titration Methods 0.000 description 5
- 229960000881 verapamil hydrochloride Drugs 0.000 description 5
- ITPDYQOUSLNIHG-UHFFFAOYSA-N Amiodarone hydrochloride Chemical compound [Cl-].CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCC[NH+](CC)CC)C(I)=C1 ITPDYQOUSLNIHG-UHFFFAOYSA-N 0.000 description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 4
- 239000002083 C09CA01 - Losartan Substances 0.000 description 4
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 4
- 206010012335 Dependence Diseases 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- 108010061435 Enalapril Proteins 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 108010007859 Lisinopril Proteins 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 4
- UWWDHYUMIORJTA-HSQYWUDLSA-N Moexipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC(OC)=C(OC)C=C2C1)C(O)=O)CC1=CC=CC=C1 UWWDHYUMIORJTA-HSQYWUDLSA-N 0.000 description 4
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 4
- 108010023197 Streptokinase Proteins 0.000 description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000012190 activator Substances 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 230000001387 anti-histamine Effects 0.000 description 4
- 239000000739 antihistaminic agent Substances 0.000 description 4
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 239000010406 cathode material Substances 0.000 description 4
- 229960001523 chlortalidone Drugs 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 238000013500 data storage Methods 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- HDRXZJPWHTXQRI-BHDTVMLSSA-N diltiazem hydrochloride Chemical compound [Cl-].C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CC[NH+](C)C)C2=CC=CC=C2S1 HDRXZJPWHTXQRI-BHDTVMLSSA-N 0.000 description 4
- 239000012636 effector Substances 0.000 description 4
- 238000005868 electrolysis reaction Methods 0.000 description 4
- 238000005530 etching Methods 0.000 description 4
- 210000004211 gastric acid Anatomy 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 229960001031 glucose Drugs 0.000 description 4
- 229910052737 gold Inorganic materials 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 229940090044 injection Drugs 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 4
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 4
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 description 4
- 229910052744 lithium Inorganic materials 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical compound ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 4
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 4
- AQCHWTWZEMGIFD-UHFFFAOYSA-N metolazone Chemical compound CC1NC2=CC(Cl)=C(S(N)(=O)=O)C=C2C(=O)N1C1=CC=CC=C1C AQCHWTWZEMGIFD-UHFFFAOYSA-N 0.000 description 4
- VWUPWEAFIOQCGF-UHFFFAOYSA-N milrinone lactate Chemical compound [H+].CC(O)C([O-])=O.N1C(=O)C(C#N)=CC(C=2C=CN=CC=2)=C1C VWUPWEAFIOQCGF-UHFFFAOYSA-N 0.000 description 4
- 235000001968 nicotinic acid Nutrition 0.000 description 4
- 239000011664 nicotinic acid Substances 0.000 description 4
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 230000001575 pathological effect Effects 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 238000007747 plating Methods 0.000 description 4
- 238000005498 polishing Methods 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 4
- 108010051412 reteplase Proteins 0.000 description 4
- 230000002441 reversible effect Effects 0.000 description 4
- 238000004062 sedimentation Methods 0.000 description 4
- VIDRYROWYFWGSY-UHFFFAOYSA-N sotalol hydrochloride Chemical compound Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 VIDRYROWYFWGSY-UHFFFAOYSA-N 0.000 description 4
- 230000003068 static effect Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 230000001360 synchronised effect Effects 0.000 description 4
- BFNXYSZBURSNHS-UVJOBNTFSA-N (2s)-1-[(2s)-6-amino-2-[[(1s)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;6-chloro-1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O.C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 BFNXYSZBURSNHS-UVJOBNTFSA-N 0.000 description 3
- RZPZLFIUFMNCLY-WLHGVMLRSA-N (e)-but-2-enedioic acid;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol Chemical compound OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1 RZPZLFIUFMNCLY-WLHGVMLRSA-N 0.000 description 3
- MEAPRSDUXBHXGD-UHFFFAOYSA-N 3-chloro-n-(4-propan-2-ylphenyl)propanamide Chemical compound CC(C)C1=CC=C(NC(=O)CCCl)C=C1 MEAPRSDUXBHXGD-UHFFFAOYSA-N 0.000 description 3
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 239000004072 C09CA03 - Valsartan Substances 0.000 description 3
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 3
- ZNIFSRGNXRYGHF-UHFFFAOYSA-N Clonidine hydrochloride Chemical compound Cl.ClC1=CC=CC(Cl)=C1NC1=NCCN1 ZNIFSRGNXRYGHF-UHFFFAOYSA-N 0.000 description 3
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 3
- 108010092160 Dactinomycin Proteins 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 description 3
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 3
- 240000007594 Oryza sativa Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 208000028017 Psychotic disease Diseases 0.000 description 3
- 229910004298 SiO 2 Inorganic materials 0.000 description 3
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 3
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 3
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 description 3
- GOEMGAFJFRBGGG-UHFFFAOYSA-N acebutolol Chemical compound CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1 GOEMGAFJFRBGGG-UHFFFAOYSA-N 0.000 description 3
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 3
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 3
- 239000012790 adhesive layer Substances 0.000 description 3
- 229930013930 alkaloid Natural products 0.000 description 3
- 150000003797 alkaloid derivatives Chemical class 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 3
- 239000003146 anticoagulant agent Substances 0.000 description 3
- 229940034982 antineoplastic agent Drugs 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 229940125717 barbiturate Drugs 0.000 description 3
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 3
- VPSRQEHTHIMDQM-FKLPMGAJSA-N benazepril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 VPSRQEHTHIMDQM-FKLPMGAJSA-N 0.000 description 3
- 229960003619 benazepril hydrochloride Drugs 0.000 description 3
- 229940099231 betapace Drugs 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 239000000812 cholinergic antagonist Substances 0.000 description 3
- 229960002925 clonidine hydrochloride Drugs 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- GJQPMPFPNINLKP-UHFFFAOYSA-N diclofenamide Chemical compound NS(=O)(=O)C1=CC(Cl)=C(Cl)C(S(N)(=O)=O)=C1 GJQPMPFPNINLKP-UHFFFAOYSA-N 0.000 description 3
- 229960002768 dipyridamole Drugs 0.000 description 3
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000002651 drug therapy Methods 0.000 description 3
- 230000002526 effect on cardiovascular system Effects 0.000 description 3
- 229960000873 enalapril Drugs 0.000 description 3
- 238000004146 energy storage Methods 0.000 description 3
- 239000003822 epoxy resin Substances 0.000 description 3
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 229960003711 glyceryl trinitrate Drugs 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 210000005003 heart tissue Anatomy 0.000 description 3
- 229920000669 heparin Polymers 0.000 description 3
- 229960001340 histamine Drugs 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000009413 insulation Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 229960004961 mechlorethamine Drugs 0.000 description 3
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 229940064639 minipress Drugs 0.000 description 3
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 3
- 229960003512 nicotinic acid Drugs 0.000 description 3
- 229960001597 nifedipine Drugs 0.000 description 3
- 229910052755 nonmetal Inorganic materials 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000000474 nursing effect Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000010363 phase shift Effects 0.000 description 3
- 229920000647 polyepoxide Polymers 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- WFXFYZULCQKPIP-UHFFFAOYSA-N prazosin hydrochloride Chemical compound [H+].[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 WFXFYZULCQKPIP-UHFFFAOYSA-N 0.000 description 3
- 229960004604 propranolol hydrochloride Drugs 0.000 description 3
- 239000011241 protective layer Substances 0.000 description 3
- IBBLRJGOOANPTQ-JKVLGAQCSA-N quinapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 IBBLRJGOOANPTQ-JKVLGAQCSA-N 0.000 description 3
- XHKUDCCTVQUHJQ-LCYSNFERSA-N quinidine D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 XHKUDCCTVQUHJQ-LCYSNFERSA-N 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 description 3
- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 3
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 3
- BMKDZUISNHGIBY-ZETCQYMHSA-N (+)-dexrazoxane Chemical compound C([C@H](C)N1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1 BMKDZUISNHGIBY-ZETCQYMHSA-N 0.000 description 2
- BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 description 2
- YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 description 2
- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 description 2
- NWXMGUDVXFXRIG-WESIUVDSSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O NWXMGUDVXFXRIG-WESIUVDSSA-N 0.000 description 2
- 229930182837 (R)-adrenaline Natural products 0.000 description 2
- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 description 2
- WLRMANUAADYWEA-NWASOUNVSA-N (S)-timolol maleate Chemical compound OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 WLRMANUAADYWEA-NWASOUNVSA-N 0.000 description 2
- VTAKZNRDSPNOAU-UHFFFAOYSA-M 2-(chloromethyl)oxirane;hydron;prop-2-en-1-amine;n-prop-2-enyldecan-1-amine;trimethyl-[6-(prop-2-enylamino)hexyl]azanium;dichloride Chemical compound Cl.[Cl-].NCC=C.ClCC1CO1.CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C VTAKZNRDSPNOAU-UHFFFAOYSA-M 0.000 description 2
- VZTMYLWJKCAXMZ-UHFFFAOYSA-N 2-[(2-chloroquinazolin-4-yl)amino]ethanol Chemical compound C1=CC=C2C(NCCO)=NC(Cl)=NC2=C1 VZTMYLWJKCAXMZ-UHFFFAOYSA-N 0.000 description 2
- FEDJGPQLLNQAIY-UHFFFAOYSA-N 2-[(6-oxo-1h-pyridazin-3-yl)oxy]acetic acid Chemical compound OC(=O)COC=1C=CC(=O)NN=1 FEDJGPQLLNQAIY-UHFFFAOYSA-N 0.000 description 2
- NZPSYYOURGWZCM-UHFFFAOYSA-N 2-butyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one;6-chloro-1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O.O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C2=NNN=N2)C(CCCC)=NC21CCCC2 NZPSYYOURGWZCM-UHFFFAOYSA-N 0.000 description 2
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical compound NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 description 2
- WYWHKKSPHMUBEB-UHFFFAOYSA-N 6-Mercaptoguanine Natural products N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 2
- XZRKEDHJXXLVSK-UHFFFAOYSA-N 6-chloro-1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide;6-phenylpteridine-2,4,7-triamine Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O.NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 XZRKEDHJXXLVSK-UHFFFAOYSA-N 0.000 description 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- JBMKAUGHUNFTOL-UHFFFAOYSA-N Aldoclor Chemical class C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC=NS2(=O)=O JBMKAUGHUNFTOL-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 229930195573 Amycin Natural products 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 102000015790 Asparaginase Human genes 0.000 description 2
- 108010024976 Asparaginase Proteins 0.000 description 2
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 description 2
- 108010006654 Bleomycin Proteins 0.000 description 2
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 2
- 239000005537 C09CA07 - Telmisartan Substances 0.000 description 2
- 229940127291 Calcium channel antagonist Drugs 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 229930186147 Cephalosporin Natural products 0.000 description 2
- 235000001258 Cinchona calisaya Nutrition 0.000 description 2
- 229920002905 Colesevelam Polymers 0.000 description 2
- 229920002911 Colestipol Polymers 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
- JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical compound C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 description 2
- 108010066671 Enalaprilat Proteins 0.000 description 2
- LMHIPJMTZHDKEW-XQYLJSSYSA-M Epoprostenol sodium Chemical compound [Na+].O1\C(=C/CCCC([O-])=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 LMHIPJMTZHDKEW-XQYLJSSYSA-M 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- CVKUMNRCIJMVAR-UHFFFAOYSA-N Fenoldopam mesylate Chemical compound CS(O)(=O)=O.C1=CC(O)=CC=C1C1C2=CC(O)=C(O)C(Cl)=C2CCNC1 CVKUMNRCIJMVAR-UHFFFAOYSA-N 0.000 description 2
- DJBNUMBKLMJRSA-UHFFFAOYSA-N Flecainide Chemical compound FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(C(=O)NCC2NCCCC2)=C1 DJBNUMBKLMJRSA-UHFFFAOYSA-N 0.000 description 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- DGFYECXYGUIODH-UHFFFAOYSA-N Guanfacine hydrochloride Chemical compound Cl.NC(N)=NC(=O)CC1=C(Cl)C=CC=C1Cl DGFYECXYGUIODH-UHFFFAOYSA-N 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 2
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
- WQVZLXWQESQGIF-UHFFFAOYSA-N Labetalol hydrochloride Chemical compound Cl.C=1C=C(O)C(C(N)=O)=CC=1C(O)CNC(C)CCC1=CC=CC=C1 WQVZLXWQESQGIF-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 description 2
- PKVZBNCYEICAQP-UHFFFAOYSA-N Mecamylamine hydrochloride Chemical compound Cl.C1CC2C(C)(C)C(NC)(C)C1C2 PKVZBNCYEICAQP-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- CESYKOGBSMNBPD-UHFFFAOYSA-N Methyclothiazide Chemical compound ClC1=C(S(N)(=O)=O)C=C2S(=O)(=O)N(C)C(CCl)NC2=C1 CESYKOGBSMNBPD-UHFFFAOYSA-N 0.000 description 2
- RGHAZVBIOOEVQX-UHFFFAOYSA-N Metoprolol succinate Chemical compound OC(=O)CCC(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 RGHAZVBIOOEVQX-UHFFFAOYSA-N 0.000 description 2
- ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 description 2
- 239000000006 Nitroglycerin Substances 0.000 description 2
- JEIZLWNUBXHADF-UHFFFAOYSA-N Pelletierine Chemical compound CC(=O)CC1CCCCN1 JEIZLWNUBXHADF-UHFFFAOYSA-N 0.000 description 2
- CYLWJCABXYDINA-UHFFFAOYSA-N Polythiazide Chemical compound ClC1=C(S(N)(=O)=O)C=C2S(=O)(=O)N(C)C(CSCC(F)(F)F)NC2=C1 CYLWJCABXYDINA-UHFFFAOYSA-N 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 description 2
- HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 description 2
- NGBFQHCMQULJNZ-UHFFFAOYSA-N Torsemide Chemical compound CC(C)NC(=O)NS(=O)(=O)C1=CN=CC=C1NC1=CC=CC(C)=C1 NGBFQHCMQULJNZ-UHFFFAOYSA-N 0.000 description 2
- VXFJYXUZANRPDJ-WTNASJBWSA-N Trandopril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 VXFJYXUZANRPDJ-WTNASJBWSA-N 0.000 description 2
- GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 description 2
- 229960000446 abciximab Drugs 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000000923 adrenergic beta-3 receptor antagonist Substances 0.000 description 2
- PXOYOCNNSUAQNS-AGNJHWRGSA-N alantolactone Chemical compound C1[C@H]2OC(=O)C(=C)[C@H]2C=C2[C@@H](C)CCC[C@@]21C PXOYOCNNSUAQNS-AGNJHWRGSA-N 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 229960003318 alteplase Drugs 0.000 description 2
- LTKVFMLMEYCWMK-UHFFFAOYSA-N amiloride hydrochloride dihydrate Chemical compound [H+].O.O.[Cl-].NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N LTKVFMLMEYCWMK-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 229960003234 amiodarone hydrochloride Drugs 0.000 description 2
- XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 description 2
- 239000002269 analeptic agent Substances 0.000 description 2
- 229940035674 anesthetics Drugs 0.000 description 2
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 2
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 description 2
- 230000000507 anthelmentic effect Effects 0.000 description 2
- 230000003288 anthiarrhythmic effect Effects 0.000 description 2
- 230000001078 anti-cholinergic effect Effects 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000003416 antiarrhythmic agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 239000003430 antimalarial agent Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 description 2
- 229960002274 atenolol Drugs 0.000 description 2
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 2
- UEECHQPWQHYEDE-UHFFFAOYSA-N bepridil hydrochloride monohydrate Chemical compound [H+].O.[Cl-].C1CCCN1C(COCC(C)C)CN(C=1C=CC=CC=1)CC1=CC=CC=C1 UEECHQPWQHYEDE-UHFFFAOYSA-N 0.000 description 2
- CHDPSNLJFOQTRK-UHFFFAOYSA-N betaxolol hydrochloride Chemical compound [Cl-].C1=CC(OCC(O)C[NH2+]C(C)C)=CC=C1CCOCC1CC1 CHDPSNLJFOQTRK-UHFFFAOYSA-N 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229960005400 bisoprolol fumarate Drugs 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229940097683 brevibloc Drugs 0.000 description 2
- 229960002092 busulfan Drugs 0.000 description 2
- 229940088033 calan Drugs 0.000 description 2
- 239000000480 calcium channel blocker Substances 0.000 description 2
- 229940088029 cardizem Drugs 0.000 description 2
- FYBXRCFPOTXTJF-UHFFFAOYSA-N carteolol hydrochloride Chemical compound [Cl-].N1C(=O)CCC2=C1C=CC=C2OCC(O)C[NH2+]C(C)(C)C FYBXRCFPOTXTJF-UHFFFAOYSA-N 0.000 description 2
- OGHNVEJMJSYVRP-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2 OGHNVEJMJSYVRP-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 229940124587 cephalosporin Drugs 0.000 description 2
- 150000001780 cephalosporins Chemical class 0.000 description 2
- GPUADMRJQVPIAS-QCVDVZFFSA-M cerivastatin sodium Chemical compound [Na+].COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 GPUADMRJQVPIAS-QCVDVZFFSA-M 0.000 description 2
- 229940044683 chemotherapy drug Drugs 0.000 description 2
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 2
- 229960002155 chlorothiazide Drugs 0.000 description 2
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 2
- 229960001076 chlorpromazine Drugs 0.000 description 2
- 229960004588 cilostazol Drugs 0.000 description 2
- RRGUKTPIGVIEKM-UHFFFAOYSA-N cilostazol Chemical compound C=1C=C2NC(=O)CCC2=CC=1OCCCCC1=NN=NN1C1CCCCC1 RRGUKTPIGVIEKM-UHFFFAOYSA-N 0.000 description 2
- KMPWYEUPVWOPIM-KODHJQJWSA-N cinchonidine Chemical compound C1=CC=C2C([C@H]([C@H]3[N@]4CC[C@H]([C@H](C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-KODHJQJWSA-N 0.000 description 2
- KMPWYEUPVWOPIM-UHFFFAOYSA-N cinchonidine Natural products C1=CC=C2C(C(C3N4CCC(C(C4)C=C)C3)O)=CC=NC2=C1 KMPWYEUPVWOPIM-UHFFFAOYSA-N 0.000 description 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- CZZBXGOYISFHRY-UHFFFAOYSA-N copper;hydroiodide Chemical compound [Cu].I CZZBXGOYISFHRY-UHFFFAOYSA-N 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 229960000640 dactinomycin Drugs 0.000 description 2
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 2
- 229960000605 dexrazoxane Drugs 0.000 description 2
- 229960005081 diclofenamide Drugs 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 229960005316 diltiazem hydrochloride Drugs 0.000 description 2
- 229940074619 diovan Drugs 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- CGDDQFMPGMYYQP-UHFFFAOYSA-N disopyramide phosphate Chemical compound OP(O)(O)=O.C=1C=CC=NC=1C(C(N)=O)(CCN(C(C)C)C(C)C)C1=CC=CC=C1 CGDDQFMPGMYYQP-UHFFFAOYSA-N 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- IXTMWRCNAAVVAI-UHFFFAOYSA-N dofetilide Chemical compound C=1C=C(NS(C)(=O)=O)C=CC=1CCN(C)CCOC1=CC=C(NS(C)(=O)=O)C=C1 IXTMWRCNAAVVAI-UHFFFAOYSA-N 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 238000004070 electrodeposition Methods 0.000 description 2
- 230000005520 electrodynamics Effects 0.000 description 2
- 239000008151 electrolyte solution Substances 0.000 description 2
- IRSFLDGTOHBADP-UHFFFAOYSA-N embelin Chemical compound CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O IRSFLDGTOHBADP-UHFFFAOYSA-N 0.000 description 2
- OYFJQPXVCSSHAI-QFPUQLAESA-N enalapril maleate Chemical compound OC(=O)\C=C/C(O)=O.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 OYFJQPXVCSSHAI-QFPUQLAESA-N 0.000 description 2
- 229960005139 epinephrine Drugs 0.000 description 2
- 229940015979 epipen Drugs 0.000 description 2
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- AQNDDEOPVVGCPG-UHFFFAOYSA-N esmolol Chemical compound COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 AQNDDEOPVVGCPG-UHFFFAOYSA-N 0.000 description 2
- 229960001015 esmolol hydrochloride Drugs 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 229960002949 fluorouracil Drugs 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 239000003193 general anesthetic agent Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000000004 hemodynamic effect Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- DMDGGSIALPNSEE-UHFFFAOYSA-N hydroflumethiazide Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O DMDGGSIALPNSEE-UHFFFAOYSA-N 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000013101 initial test Methods 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 238000007913 intrathecal administration Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- YOSHYTLCDANDAN-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2NN=NN=2)C(CCCC)=NC21CCCC2 YOSHYTLCDANDAN-UHFFFAOYSA-N 0.000 description 2
- 229960003827 isosorbide mononitrate Drugs 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 229960001375 lactose Drugs 0.000 description 2
- 229940063699 lanoxin Drugs 0.000 description 2
- 229960002394 lisinopril Drugs 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- PSIFNNKUMBGKDQ-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 PSIFNNKUMBGKDQ-UHFFFAOYSA-N 0.000 description 2
- 229940080268 lotensin Drugs 0.000 description 2
- 229960004844 lovastatin Drugs 0.000 description 2
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229960001924 melphalan Drugs 0.000 description 2
- 229960000901 mepacrine Drugs 0.000 description 2
- 229960000485 methotrexate Drugs 0.000 description 2
- 229960003739 methyclothiazide Drugs 0.000 description 2
- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 description 2
- 229960002817 metolazone Drugs 0.000 description 2
- VLPIATFUUWWMKC-UHFFFAOYSA-N mexiletine Chemical compound CC(N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-UHFFFAOYSA-N 0.000 description 2
- 229960003574 milrinone Drugs 0.000 description 2
- 229960001720 milrinone lactate Drugs 0.000 description 2
- CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 2
- 229960004857 mitomycin Drugs 0.000 description 2
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000001259 photo etching Methods 0.000 description 2
- 238000001020 plasma etching Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 229960003171 plicamycin Drugs 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- VWBQYTRBTXKKOG-IYNICTALSA-M pravastatin sodium Chemical compound [Na+].C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 VWBQYTRBTXKKOG-IYNICTALSA-M 0.000 description 2
- 239000010970 precious metal Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- ABTXGJFUQRCPNH-UHFFFAOYSA-N procainamide hydrochloride Chemical compound [H+].[Cl-].CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 ABTXGJFUQRCPNH-UHFFFAOYSA-N 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- XWIHRGFIPXWGEF-UHFFFAOYSA-N propafenone hydrochloride Chemical compound Cl.CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 XWIHRGFIPXWGEF-UHFFFAOYSA-N 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 230000001902 propagating effect Effects 0.000 description 2
- 229960003712 propranolol Drugs 0.000 description 2
- 229940117820 purinethol Drugs 0.000 description 2
- GPKJTRJOBQGKQK-UHFFFAOYSA-N quinacrine Chemical compound C1=C(OC)C=C2C(NC(C)CCCN(CC)CC)=C(C=CC(Cl)=C3)C3=NC2=C1 GPKJTRJOBQGKQK-UHFFFAOYSA-N 0.000 description 2
- 229960003042 quinapril hydrochloride Drugs 0.000 description 2
- 229960001404 quinidine Drugs 0.000 description 2
- 229960002454 quinidine gluconate Drugs 0.000 description 2
- 229960000948 quinine Drugs 0.000 description 2
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001739 rebound effect Effects 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 229940116243 retavase Drugs 0.000 description 2
- 229960002917 reteplase Drugs 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229940082552 sectral Drugs 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- XUIMIQQOPSSXEZ-AKLPVKDBSA-N silicon-31 atom Chemical compound [31Si] XUIMIQQOPSSXEZ-AKLPVKDBSA-N 0.000 description 2
- 229960002855 simvastatin Drugs 0.000 description 2
- 210000002460 smooth muscle Anatomy 0.000 description 2
- TVTJZMHAIQQZTL-WATAJHSMSA-M sodium;(2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate Chemical compound [Na+].C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C([O-])=O)CCCC1=CC=CC=C1 TVTJZMHAIQQZTL-WATAJHSMSA-M 0.000 description 2
- CWCSCNSKBSCYCS-UHFFFAOYSA-M sodium;2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetate Chemical compound [Na+].CCC(=C)C(=O)C1=CC=C(OCC([O-])=O)C(Cl)=C1Cl CWCSCNSKBSCYCS-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000002048 spasmolytic effect Effects 0.000 description 2
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 229960005202 streptokinase Drugs 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 2
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 2
- 229940124530 sulfonamide Drugs 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 description 2
- 229960000580 terconazole Drugs 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 2
- 229960005053 tinidazole Drugs 0.000 description 2
- MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 description 2
- 229960003087 tioguanine Drugs 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 230000024883 vasodilation Effects 0.000 description 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 2
- 229960004528 vincristine Drugs 0.000 description 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- NGZXDRGWBULKFA-NSOVKSMOSA-N (+)-Bebeerine Chemical compound C([C@@H]1N(C)CCC=2C=C(C(=C(OC3=CC=C(C=C3)C[C@H]3C=4C=C(C(=CC=4CCN3C)OC)O3)C=21)O)OC)C1=CC=C(O)C3=C1 NGZXDRGWBULKFA-NSOVKSMOSA-N 0.000 description 1
- NHTGHBARYWONDQ-UHFFFAOYSA-N (+-)-α-methyl-tyrosine Chemical compound OC(=O)C(N)(C)CC1=CC=C(O)C=C1 NHTGHBARYWONDQ-UHFFFAOYSA-N 0.000 description 1
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 description 1
- YKJYKKNCCRKFSL-RDBSUJKOSA-N (-)-anisomycin Chemical compound C1=CC(OC)=CC=C1C[C@@H]1[C@H](OC(C)=O)[C@@H](O)CN1 YKJYKKNCCRKFSL-RDBSUJKOSA-N 0.000 description 1
- YKSVGLFNJPQDJE-YDMQLZBCSA-N (19E,21E,23E,25E,27E,29E,31E)-33-[(2R,3S,4R,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-17-[7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl]-1,3,5,7,37-pentahydroxy-18-methyl-9,13,15-trioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid Chemical compound CC(CC(C)C1OC(=O)CC(=O)CCCC(=O)CC(O)CC(O)CC(O)CC2(O)CC(O)C(C(CC(O[C@@H]3O[C@H](C)[C@@H](O)[C@@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C1C)O2)C(O)=O)C(O)CC(=O)C1=CC=C(N)C=C1 YKSVGLFNJPQDJE-YDMQLZBCSA-N 0.000 description 1
- BUJAGSGYPOAWEI-SECBINFHSA-N (2r)-2-amino-n-(2,6-dimethylphenyl)propanamide Chemical compound C[C@@H](N)C(=O)NC1=C(C)C=CC=C1C BUJAGSGYPOAWEI-SECBINFHSA-N 0.000 description 1
- XEQLFNPSYWZPOW-NUOYRARPSA-N (2r)-4-amino-n-[(1r,2s,3r,4r,5s)-5-amino-4-[(2r,3r,4r,5s,6r)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-2-hydroxycyclohexyl]-2-hydroxybutanamide Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O[C@@H]1[C@@H]([C@H](O)[C@@H](CO)O1)O)O)NC(=O)[C@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1N XEQLFNPSYWZPOW-NUOYRARPSA-N 0.000 description 1
- YLXIPWWIOISBDD-NDAAPVSOSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;4-[(1r)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.CNC[C@H](O)C1=CC=C(O)C(O)=C1 YLXIPWWIOISBDD-NDAAPVSOSA-N 0.000 description 1
- CIDUJQMULVCIBT-MQDUPKMGSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4-amino-3-[[(2s,3r)-3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](NC)[C@@](C)(O)CO1)O)NCC)[C@H]1OC(CN)=CC[C@H]1N CIDUJQMULVCIBT-MQDUPKMGSA-N 0.000 description 1
- XBNDESPXQUOOBQ-LSMLZNGOSA-N (2r,3s)-4-[[(2s)-1-[[2-[[(2s)-1-[[2-[[(2r,3s)-1-[[(2s)-1-[(2s)-2-[[(1s)-1-[(3s,9ar)-1,4-dioxo-3,6,7,8,9,9a-hexahydro-2h-pyrido[1,2-a]pyrazin-3-yl]ethyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-3-amino-1-oxobutan-2-yl]amino]-2-oxoethyl]am Chemical compound CCC(C)CCCCC\C=C\CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)C(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H]([C@H](C)N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N1 XBNDESPXQUOOBQ-LSMLZNGOSA-N 0.000 description 1
- OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical compound CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 description 1
- PPAGZPRHIOKKLV-WDFOJNLTSA-N (2s,3ar,7as)-1-[(2s)-2-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid;2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@@H]2C[C@H]1C(O)=O)CC1=CC=CC=C1.C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 PPAGZPRHIOKKLV-WDFOJNLTSA-N 0.000 description 1
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- VCOPTHOUUNAYKQ-WBTCAYNUSA-N (3s)-3,6-diamino-n-[[(2s,5s,8e,11s,15s)-15-amino-11-[(6r)-2-amino-1,4,5,6-tetrahydropyrimidin-6-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide;(3s)-3,6-diamino-n-[[(2s,5s,8 Chemical compound N1C(=O)\C(=C/NC(N)=O)NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](C)NC(=O)[C@@H](N)CNC(=O)[C@@H]1[C@@H]1NC(N)=NCC1.N1C(=O)\C(=C/NC(N)=O)NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC(=O)[C@@H]1[C@@H]1NC(N)=NCC1 VCOPTHOUUNAYKQ-WBTCAYNUSA-N 0.000 description 1
- COQLWTPLWDQKID-UHFFFAOYSA-N (4-acetamido-3-methylphenyl)arsonic acid Chemical compound CC(=O)NC1=CC=C([As](O)(O)=O)C=C1C COQLWTPLWDQKID-UHFFFAOYSA-N 0.000 description 1
- DHPRQBPJLMKORJ-XRNKAMNCSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O DHPRQBPJLMKORJ-XRNKAMNCSA-N 0.000 description 1
- SQEBMLCQNJOCBG-HVHJFMEUSA-N (5s)-3-(hydroxymethyl)-5-methoxy-4-methyl-5-[(e)-2-phenylethenyl]furan-2-one Chemical compound C=1C=CC=CC=1/C=C/[C@]1(OC)OC(=O)C(CO)=C1C SQEBMLCQNJOCBG-HVHJFMEUSA-N 0.000 description 1
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 description 1
- ZHNFLHYOFXQIOW-AHSOWCEXSA-N (s)-[(2r,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid;dihydrate Chemical compound O.O.OS(O)(=O)=O.C([C@H]([C@H](C1)C=C)C2)CN1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21.C([C@H]([C@H](C1)C=C)C2)CN1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 ZHNFLHYOFXQIOW-AHSOWCEXSA-N 0.000 description 1
- VBNWVOUHHNQVEP-ODZAUARKSA-N (z)-but-2-enedioic acid;thiophene Chemical compound C=1C=CSC=1.OC(=O)\C=C/C(O)=O VBNWVOUHHNQVEP-ODZAUARKSA-N 0.000 description 1
- ULNVBRUIKLYGDF-UHFFFAOYSA-N 1,3-bis(4-methylphenyl)thiourea Chemical compound C1=CC(C)=CC=C1NC(=S)NC1=CC=C(C)C=C1 ULNVBRUIKLYGDF-UHFFFAOYSA-N 0.000 description 1
- ZRHUHDUEXWHZMA-UHFFFAOYSA-N 1,4-dihydropyrazol-5-one Chemical compound O=C1CC=NN1 ZRHUHDUEXWHZMA-UHFFFAOYSA-N 0.000 description 1
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 description 1
- GJHKWLSRHNWTAN-UHFFFAOYSA-N 1-ethoxy-4-(4-pentylcyclohexyl)benzene Chemical compound C1CC(CCCCC)CCC1C1=CC=C(OCC)C=C1 GJHKWLSRHNWTAN-UHFFFAOYSA-N 0.000 description 1
- IPVYMXZYXFFDGW-UHFFFAOYSA-N 1-methylpiperidin-4-ol;hydrochloride Chemical compound Cl.CN1CCC(O)CC1 IPVYMXZYXFFDGW-UHFFFAOYSA-N 0.000 description 1
- NBAFIBBHADOTMU-UHFFFAOYSA-N 1-n-(6-methoxyquinolin-8-yl)pentane-1,4-diamine Chemical compound N1=CC=CC2=CC(OC)=CC(NCCCC(C)N)=C21 NBAFIBBHADOTMU-UHFFFAOYSA-N 0.000 description 1
- LLSKXGRDUPMXLC-UHFFFAOYSA-N 1-phenylpiperidine Chemical compound C1CCCCN1C1=CC=CC=C1 LLSKXGRDUPMXLC-UHFFFAOYSA-N 0.000 description 1
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 description 1
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
- 239000003315 2-(4-chlorophenoxy)-2-methylpropanoic acid Substances 0.000 description 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
- NOHUXXDTQJPXSB-UHFFFAOYSA-N 2-acetyloxybenzoic acid;2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O.C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 NOHUXXDTQJPXSB-UHFFFAOYSA-N 0.000 description 1
- PTKSEFOSCHHMPD-SNVBAGLBSA-N 2-amino-n-[(2s)-2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide Chemical compound COC1=CC=C(OC)C([C@H](O)CNC(=O)CN)=C1 PTKSEFOSCHHMPD-SNVBAGLBSA-N 0.000 description 1
- ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical compound OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 description 1
- KISZTEOELCMZPY-UHFFFAOYSA-N 3,3-diphenylpropylamine Chemical compound C=1C=CC=CC=1C(CCN)C1=CC=CC=C1 KISZTEOELCMZPY-UHFFFAOYSA-N 0.000 description 1
- IGMMTYZWNUSEEU-UHFFFAOYSA-N 3-(2-chloroethyl)-1-cyclohexyl-1-nitrosourea Chemical compound ClCCNC(=O)N(N=O)C1CCCCC1 IGMMTYZWNUSEEU-UHFFFAOYSA-N 0.000 description 1
- WUIABRMSWOKTOF-OYALTWQYSA-N 3-[[2-[2-[2-[[(2s,3r)-2-[[(2s,3s,4r)-4-[[(2s,3r)-2-[[6-amino-2-[(1s)-3-amino-1-[[(2s)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2r,3s,4s,5s,6s)-3-[(2r,3s,4s,5r,6r)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)ox Chemical compound OS([O-])(=O)=O.N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1NC=NC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C WUIABRMSWOKTOF-OYALTWQYSA-N 0.000 description 1
- OIUFZCFTZDBOBQ-ZLADKUJESA-N 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide;(2r,3s)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C.C1=C(C(F)(F)F)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1=CC=CC=C1 OIUFZCFTZDBOBQ-ZLADKUJESA-N 0.000 description 1
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 1
- MAAQGZFMFXQVOG-UHFFFAOYSA-N 4,4-diphenylbutan-1-amine Chemical compound C=1C=CC=CC=1C(CCCN)C1=CC=CC=C1 MAAQGZFMFXQVOG-UHFFFAOYSA-N 0.000 description 1
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 description 1
- GJOHLWZHWQUKAU-UHFFFAOYSA-N 5-azaniumylpentan-2-yl-(6-methoxyquinolin-8-yl)azanium;dihydrogen phosphate Chemical compound OP(O)(O)=O.OP(O)(O)=O.N1=CC=CC2=CC(OC)=CC(NC(C)CCCN)=C21 GJOHLWZHWQUKAU-UHFFFAOYSA-N 0.000 description 1
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 description 1
- LCGTWRLJTMHIQZ-UHFFFAOYSA-N 5H-dibenzo[b,f]azepine Chemical class C1=CC2=CC=CC=C2NC2=CC=CC=C21 LCGTWRLJTMHIQZ-UHFFFAOYSA-N 0.000 description 1
- UIYUUEDFAMZISF-FTBISJDPSA-N 6-chloro-1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide;(2s)-3-methyl-2-[pentanoyl-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O.C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NNN=N1 UIYUUEDFAMZISF-FTBISJDPSA-N 0.000 description 1
- RFNRSUBWOXSCLB-FXFKJASFSA-N 6-chloro-1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide;s-[(7r,8r,9s,10r,13s,14s,17r)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O.C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 RFNRSUBWOXSCLB-FXFKJASFSA-N 0.000 description 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical group S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 description 1
- PQJUJGAVDBINPI-UHFFFAOYSA-N 9H-thioxanthene Chemical compound C1=CC=C2CC3=CC=CC=C3SC2=C1 PQJUJGAVDBINPI-UHFFFAOYSA-N 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- OVCDSSHSILBFBN-UHFFFAOYSA-N Amodiaquine Chemical compound C1=C(O)C(CN(CC)CC)=CC(NC=2C3=CC=C(Cl)C=C3N=CC=2)=C1 OVCDSSHSILBFBN-UHFFFAOYSA-N 0.000 description 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- YKJYKKNCCRKFSL-UHFFFAOYSA-N Anisomycin Natural products C1=CC(OC)=CC=C1CC1C(OC(C)=O)C(O)CN1 YKJYKKNCCRKFSL-UHFFFAOYSA-N 0.000 description 1
- MGYMHQJELJYRQS-UHFFFAOYSA-N Ascaridole Chemical compound C1CC2(C)OOC1(C(C)C)C=C2 MGYMHQJELJYRQS-UHFFFAOYSA-N 0.000 description 1
- GJRJTYFSORWKBE-UHFFFAOYSA-N Aspidinol Chemical compound CCCC(=O)C1=C(O)C=C(OC)C(C)=C1O GJRJTYFSORWKBE-UHFFFAOYSA-N 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 239000005528 B01AC05 - Ticlopidine Substances 0.000 description 1
- 108010001478 Bacitracin Proteins 0.000 description 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 1
- 229930183180 Butirosin Natural products 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 239000002947 C09CA04 - Irbesartan Substances 0.000 description 1
- MUAOHYJGHYFDSA-YZMLMZOASA-N CCCCC1C\C=C\C=C\C=C\C=C\[C@@H](C[C@@H]2O[C@@](O)(C[C@H](O)[C@H]2C(O)=O)C[C@@H](O)C[C@H]2O[C@@H]2\C=C\C(=O)O1)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N)[C@@H]1O Chemical compound CCCCC1C\C=C\C=C\C=C\C=C\[C@@H](C[C@@H]2O[C@@](O)(C[C@H](O)[C@H]2C(O)=O)C[C@@H](O)C[C@H]2O[C@@H]2\C=C\C(=O)O1)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N)[C@@H]1O MUAOHYJGHYFDSA-YZMLMZOASA-N 0.000 description 1
- PHZDLMOVTNOUBV-UHFFFAOYSA-N CCl.[O] Chemical compound CCl.[O] PHZDLMOVTNOUBV-UHFFFAOYSA-N 0.000 description 1
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 108010065839 Capreomycin Proteins 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- JWBOIMRXGHLCPP-UHFFFAOYSA-N Chloditan Chemical compound C=1C=CC=C(Cl)C=1C(C(Cl)Cl)C1=CC=C(Cl)C=C1 JWBOIMRXGHLCPP-UHFFFAOYSA-N 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010219 Compulsions Diseases 0.000 description 1
- 239000004821 Contact adhesive Substances 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 102100021906 Cyclin-O Human genes 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- FBMORZZOJSDNRQ-UHFFFAOYSA-N Demethoxy,B,HCl-Adriamycin Natural products C1C2C(=C)CCCC2(C)CC2(O)C1=C(C)C(=O)O2 FBMORZZOJSDNRQ-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- MDNWOSOZYLHTCG-UHFFFAOYSA-N Dichlorophen Chemical compound OC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1O MDNWOSOZYLHTCG-UHFFFAOYSA-N 0.000 description 1
- ASXBYYWOLISCLQ-UHFFFAOYSA-N Dihydrostreptomycin Natural products O1C(CO)C(O)C(O)C(NC)C1OC1C(CO)(O)C(C)OC1OC1C(N=C(N)N)C(O)C(N=C(N)N)C(O)C1O ASXBYYWOLISCLQ-UHFFFAOYSA-N 0.000 description 1
- 206010013754 Drug withdrawal syndrome Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108010056764 Eptifibatide Proteins 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 229930183931 Filipin Natural products 0.000 description 1
- 229930195503 Fortimicin Natural products 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- AGJUUQSLGVCRQA-SWOUQTJZSA-N Fungichromin Chemical compound CCCCC[C@@H](O)[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)[C@@H](O)[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC1=O AGJUUQSLGVCRQA-SWOUQTJZSA-N 0.000 description 1
- MZHMKNKHHJVDLK-UHFFFAOYSA-N Fungichromin Natural products CCCCCC(O)C1C(O)CC(O)CC(O)CC(O)CC(O)CC(O)C(O)C(O)C(=CC=CC=CC=CC=CC(C)C(C)OC1=O)C MZHMKNKHHJVDLK-UHFFFAOYSA-N 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- DNYGXMICFMACRA-XHEDQWPISA-N Gentamicin C2b Chemical compound O1[C@H](CNC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N DNYGXMICFMACRA-XHEDQWPISA-N 0.000 description 1
- DUAGQYUORDTXOR-GPQRQXLASA-N Gentiopicrin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](C=C)C2=CCOC(=O)C2=CO1 DUAGQYUORDTXOR-GPQRQXLASA-N 0.000 description 1
- DUAGQYUORDTXOR-WULZUDSJSA-N Gentiopicrin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@H]1[C@@H](C=C)C=2C(C(=O)OCC=2)=CO1 DUAGQYUORDTXOR-WULZUDSJSA-N 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- FOHHNHSLJDZUGQ-VWLOTQADSA-N Halofantrine Chemical compound FC(F)(F)C1=CC=C2C([C@@H](O)CCN(CCCC)CCCC)=CC3=C(Cl)C=C(Cl)C=C3C2=C1 FOHHNHSLJDZUGQ-VWLOTQADSA-N 0.000 description 1
- 229930195098 Hamycin Natural products 0.000 description 1
- 239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 description 1
- 101000897441 Homo sapiens Cyclin-O Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- PCIOHQNIRPWFMV-WXXKFALUSA-N Ibutilide fumarate Chemical compound OC(=O)\C=C\C(O)=O.CCCCCCCN(CC)CCCC(O)C1=CC=C(NS(C)(=O)=O)C=C1.CCCCCCCN(CC)CCCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 PCIOHQNIRPWFMV-WXXKFALUSA-N 0.000 description 1
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- NTAFJUSDNOSFFY-UHFFFAOYSA-N Ipronidazole Chemical compound CC(C)C1=NC=C([N+]([O-])=O)N1C NTAFJUSDNOSFFY-UHFFFAOYSA-N 0.000 description 1
- WXFIGDLSSYIKKV-RCOVLWMOSA-N L-Metaraminol Chemical compound C[C@H](N)[C@H](O)C1=CC=CC(O)=C1 WXFIGDLSSYIKKV-RCOVLWMOSA-N 0.000 description 1
- NHTGHBARYWONDQ-JTQLQIEISA-N L-α-methyl-Tyrosine Chemical compound OC(=O)[C@](N)(C)CC1=CC=C(O)C=C1 NHTGHBARYWONDQ-JTQLQIEISA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- WESWYMRNZNDGBX-YLCXCWDSSA-N Mefloquine hydrochloride Chemical compound Cl.C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 WESWYMRNZNDGBX-YLCXCWDSSA-N 0.000 description 1
- SGDBTWWWUNNDEQ-UHFFFAOYSA-N Merphalan Chemical compound OC(=O)C(N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-UHFFFAOYSA-N 0.000 description 1
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 description 1
- 229930192392 Mitomycin Natural products 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 235000009421 Myristica fragrans Nutrition 0.000 description 1
- AXDLCFOOGCNDST-UHFFFAOYSA-N N-methyl-DL-tyrosine Natural products CNC(C(O)=O)CC1=CC=C(O)C=C1 AXDLCFOOGCNDST-UHFFFAOYSA-N 0.000 description 1
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- CANCCLAKQQHLNK-LSDHHAIUSA-N O-[[(1R,8S)-4-tricyclo[6.2.1.02,7]undeca-2(7),3,5-trienyl]] N-methyl-N-(3-methylphenyl)carbamothioate Chemical compound CN(C(=S)Oc1ccc2[C@H]3CC[C@H](C3)c2c1)c1cccc(C)c1 CANCCLAKQQHLNK-LSDHHAIUSA-N 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 239000008896 Opium Substances 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- AGJUUQSLGVCRQA-UHFFFAOYSA-N Pentamycin Natural products CCCCCC(O)C1C(O)CC(O)CC(O)CC(O)CC(O)CC(O)C(O)C(O)C(C)=CC=CC=CC=CC=CC(O)C(C)OC1=O AGJUUQSLGVCRQA-UHFFFAOYSA-N 0.000 description 1
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 244000137852 Petrea volubilis Species 0.000 description 1
- QZVCTJOXCFMACW-UHFFFAOYSA-N Phenoxybenzamine Chemical compound C=1C=CC=CC=1CN(CCCl)C(C)COC1=CC=CC=C1 QZVCTJOXCFMACW-UHFFFAOYSA-N 0.000 description 1
- VBCPVIWPDJVHAN-UHFFFAOYSA-N Phenoxybenzamine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C[NH+](CCCl)C(C)COC1=CC=CC=C1 VBCPVIWPDJVHAN-UHFFFAOYSA-N 0.000 description 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 241000282405 Pongo abelii Species 0.000 description 1
- 229940122767 Potassium sparing diuretic Drugs 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 229920003110 Primojel Polymers 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 description 1
- 229930189077 Rifamycin Natural products 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- BNRNXUUZRGQAQC-UHFFFAOYSA-N Sildenafil Natural products CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 1
- 229930192786 Sisomicin Natural products 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 108010039185 Tenecteplase Proteins 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000004243 Tubulin Human genes 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
- 108010078660 Vaseretic Proteins 0.000 description 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- NRYOMRCWNKNXOX-UHFFFAOYSA-N [Na].[Na].[As](O)(O)(O)=O Chemical compound [Na].[Na].[As](O)(O)(O)=O NRYOMRCWNKNXOX-UHFFFAOYSA-N 0.000 description 1
- 229940098876 abciximab injection Drugs 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 229940077422 accupril Drugs 0.000 description 1
- 229940092576 accuretic Drugs 0.000 description 1
- 229960002122 acebutolol Drugs 0.000 description 1
- KTUFKADDDORSSI-UHFFFAOYSA-N acebutolol hydrochloride Chemical compound Cl.CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1 KTUFKADDDORSSI-UHFFFAOYSA-N 0.000 description 1
- AMTPYFGPPVFBBI-UHFFFAOYSA-N acedapsone Chemical compound C1=CC(NC(=O)C)=CC=C1S(=O)(=O)C1=CC=C(NC(C)=O)C=C1 AMTPYFGPPVFBBI-UHFFFAOYSA-N 0.000 description 1
- 229950009438 acedapsone Drugs 0.000 description 1
- 229940062352 aceon Drugs 0.000 description 1
- ODFJOVXVLFUVNQ-UHFFFAOYSA-N acetarsol Chemical compound CC(=O)NC1=CC([As](O)(O)=O)=CC=C1O ODFJOVXVLFUVNQ-UHFFFAOYSA-N 0.000 description 1
- 229960002364 acetarsol Drugs 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229940099983 activase Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229940099424 adenocard Drugs 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 102000019997 adhesion receptor Human genes 0.000 description 1
- 108010013985 adhesion receptor Proteins 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000001800 adrenalinergic effect Effects 0.000 description 1
- 239000000464 adrenergic agent Substances 0.000 description 1
- 239000000048 adrenergic agonist Substances 0.000 description 1
- 239000000674 adrenergic antagonist Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 229940003558 aggrenox Drugs 0.000 description 1
- 229940060238 agrylin Drugs 0.000 description 1
- PXOYOCNNSUAQNS-UHFFFAOYSA-N alantolactone Natural products C1C2OC(=O)C(=C)C2C=C2C(C)CCCC21C PXOYOCNNSUAQNS-UHFFFAOYSA-N 0.000 description 1
- 229940007499 aldactazide Drugs 0.000 description 1
- 229940092229 aldactone Drugs 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 229940077927 altace Drugs 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 229950006446 amfomycin Drugs 0.000 description 1
- 229960004821 amikacin Drugs 0.000 description 1
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 description 1
- 229960004104 amiloride hydrochloride Drugs 0.000 description 1
- UJRRDDHEMZLWFI-UHFFFAOYSA-N aminitrozole Chemical compound CC(=O)NC1=NC=C([N+]([O-])=O)S1 UJRRDDHEMZLWFI-UHFFFAOYSA-N 0.000 description 1
- 229950000695 aminitrozole Drugs 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 229960000528 amlodipine Drugs 0.000 description 1
- 229960004005 amlodipine besylate Drugs 0.000 description 1
- UFLRJROFPAGRPN-UHFFFAOYSA-N amocarzine Chemical compound C1CN(C)CCN1C(=S)NC(C=C1)=CC=C1NC1=CC=C([N+]([O-])=O)C=C1 UFLRJROFPAGRPN-UHFFFAOYSA-N 0.000 description 1
- 229950006914 amocarzine Drugs 0.000 description 1
- 229960001444 amodiaquine Drugs 0.000 description 1
- DKVNAGXPRSYHLB-UHFFFAOYSA-N amoscanate Chemical compound C1=CC([N+](=O)[O-])=CC=C1NC1=CC=C(N=C=S)C=C1 DKVNAGXPRSYHLB-UHFFFAOYSA-N 0.000 description 1
- 229950008286 amoscanate Drugs 0.000 description 1
- 229940072174 amphenicols Drugs 0.000 description 1
- 108010079465 amphomycin Proteins 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 229960003942 amphotericin b Drugs 0.000 description 1
- 229960001220 amsacrine Drugs 0.000 description 1
- 230000001195 anabolic effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- OTBXOEAOVRKTNQ-UHFFFAOYSA-N anagrelide Chemical compound N1=C2NC(=O)CN2CC2=C(Cl)C(Cl)=CC=C21 OTBXOEAOVRKTNQ-UHFFFAOYSA-N 0.000 description 1
- 229960003555 anagrelide hydrochloride Drugs 0.000 description 1
- 230000003555 analeptic effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001466 anti-adreneric effect Effects 0.000 description 1
- 230000000398 anti-amebic effect Effects 0.000 description 1
- 230000000567 anti-anemic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000002402 anti-lipaemic effect Effects 0.000 description 1
- 230000000078 anti-malarial effect Effects 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 230000000884 anti-protozoa Effects 0.000 description 1
- 230000000842 anti-protozoal effect Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 description 1
- 229940124572 antihypotensive agent Drugs 0.000 description 1
- 229940111136 antiinflammatory and antirheumatic drug fenamates Drugs 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940127218 antiplatelet drug Drugs 0.000 description 1
- 239000003904 antiprotozoal agent Substances 0.000 description 1
- 239000000164 antipsychotic agent Substances 0.000 description 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 description 1
- 229960004676 antithrombotic agent Drugs 0.000 description 1
- 239000003716 antitrichomonal agent Substances 0.000 description 1
- 239000003702 antitrypanosomal agent Substances 0.000 description 1
- 229940124578 antitrypanosomal agent Drugs 0.000 description 1
- 239000003434 antitussive agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- HRWVXKVRSNICJQ-GMJIGYHYSA-N apicycline Chemical compound O=C([C@@]1(O)C(O)=C2[C@@H]([C@](C3=CC=CC(O)=C3C2=O)(C)O)C[C@H]1[C@@H](C=1O)N(C)C)C=1C(=O)NC(C(O)=O)N1CCN(CCO)CC1 HRWVXKVRSNICJQ-GMJIGYHYSA-N 0.000 description 1
- 229950008405 apicycline Drugs 0.000 description 1
- 229950006334 apramycin Drugs 0.000 description 1
- XZNUGFQTQHRASN-XQENGBIVSA-N apramycin Chemical compound O([C@H]1O[C@@H]2[C@H](O)[C@@H]([C@H](O[C@H]2C[C@H]1N)O[C@@H]1[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O XZNUGFQTQHRASN-XQENGBIVSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960005397 arbekacin Drugs 0.000 description 1
- MKKYBZZTJQGVCD-XTCKQBCOSA-N arbekacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)CC[C@H]1N MKKYBZZTJQGVCD-XTCKQBCOSA-N 0.000 description 1
- 229930191701 arteannuin Natural products 0.000 description 1
- 229960000981 artemether Drugs 0.000 description 1
- 229960004191 artemisinin Drugs 0.000 description 1
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 description 1
- NLYNIRQVMRLPIQ-XQLAAWPRSA-N artemotil Chemical compound C1C[C@H]2[C@H](C)CC[C@H]3[C@@H](C)[C@@H](OCC)O[C@H]4[C@]32OO[C@@]1(C)O4 NLYNIRQVMRLPIQ-XQLAAWPRSA-N 0.000 description 1
- 229960002970 artemotil Drugs 0.000 description 1
- 229960004991 artesunate Drugs 0.000 description 1
- FIHJKUPKCHIPAT-AHIGJZGOSA-N artesunate Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2O[C@@H](OC(=O)CCC(O)=O)[C@@H]4C FIHJKUPKCHIPAT-AHIGJZGOSA-N 0.000 description 1
- 210000000544 articulatio talocruralis Anatomy 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- MGYMHQJELJYRQS-ZJUUUORDSA-N ascaridole Natural products C1C[C@]2(C)OO[C@@]1(C(C)C)C=C2 MGYMHQJELJYRQS-ZJUUUORDSA-N 0.000 description 1
- 229960003272 asparaginase Drugs 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 description 1
- 229940058087 atacand Drugs 0.000 description 1
- METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 description 1
- 229960001770 atorvastatin calcium Drugs 0.000 description 1
- FQCKMBLVYCEXJB-MNSAWQCASA-L atorvastatin calcium Chemical compound [Ca+2].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1.C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 FQCKMBLVYCEXJB-MNSAWQCASA-L 0.000 description 1
- KUCQYCKVKVOKAY-CTYIDZIISA-N atovaquone Chemical compound C1([C@H]2CC[C@@H](CC2)C2=C(C(C3=CC=CC=C3C2=O)=O)O)=CC=C(Cl)C=C1 KUCQYCKVKVOKAY-CTYIDZIISA-N 0.000 description 1
- 229960003159 atovaquone Drugs 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 229940062309 avalide Drugs 0.000 description 1
- 229940000201 avapro Drugs 0.000 description 1
- JPNZKPRONVOMLL-UHFFFAOYSA-N azane;octadecanoic acid Chemical class [NH4+].CCCCCCCCCCCCCCCCCC([O-])=O JPNZKPRONVOMLL-UHFFFAOYSA-N 0.000 description 1
- 229960002278 azidamfenicol Drugs 0.000 description 1
- SGRUZFCHLOFYHZ-MWLCHTKSSA-N azidamfenicol Chemical compound [N-]=[N+]=NCC(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 SGRUZFCHLOFYHZ-MWLCHTKSSA-N 0.000 description 1
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 description 1
- 229960003644 aztreonam Drugs 0.000 description 1
- 229960003071 bacitracin Drugs 0.000 description 1
- 229930184125 bacitracin Natural products 0.000 description 1
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 1
- PERZMHJGZKHNGU-JGYWJTCASA-N bambermycin Chemical compound O([C@H]1[C@H](NC(C)=O)[C@@H](O)[C@@H]([C@H](O1)CO[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@@H]1O[C@@H]([C@H]([C@H](O)[C@H]1NC(C)=O)O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@H](O1)C(=O)NC=1C(CCC=1O)=O)O)C)[C@H]1[C@@H](OP(O)(=O)OC[C@@H](OC\C=C(/C)CC\C=C\C(C)(C)CCC(=C)C\C=C(/C)CCC=C(C)C)C(O)=O)O[C@H](C(O)=O)[C@@](C)(O)[C@@H]1OC(N)=O PERZMHJGZKHNGU-JGYWJTCASA-N 0.000 description 1
- 229950007118 bambermycin Drugs 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- HDWIHXWEUNVBIY-UHFFFAOYSA-N bendroflumethiazidum Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1=CC=CC=C1 HDWIHXWEUNVBIY-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229940076134 benzene Drugs 0.000 description 1
- 150000001555 benzenes Chemical class 0.000 description 1
- 229960004156 bepridil hydrochloride Drugs 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229960004347 betaxolol hydrochloride Drugs 0.000 description 1
- LLUJWFHAQXWJOF-UHFFFAOYSA-N betazole Chemical compound NCCC1=CC=N[N]1 LLUJWFHAQXWJOF-UHFFFAOYSA-N 0.000 description 1
- 229960002114 betazole Drugs 0.000 description 1
- 229940108502 bicnu Drugs 0.000 description 1
- 229960002206 bifonazole Drugs 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- OMWQUXGVXQELIX-UHFFFAOYSA-N bitoscanate Chemical compound S=C=NC1=CC=C(N=C=S)C=C1 OMWQUXGVXQELIX-UHFFFAOYSA-N 0.000 description 1
- 229950002418 bitoscanate Drugs 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- 239000003918 blood extract Substances 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 210000000746 body region Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 229960002962 butenafine Drugs 0.000 description 1
- ABJKWBDEJIDSJZ-UHFFFAOYSA-N butenafine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)CC1=CC=C(C(C)(C)C)C=C1 ABJKWBDEJIDSJZ-UHFFFAOYSA-N 0.000 description 1
- 229950004527 butirosin Drugs 0.000 description 1
- SWLMUYACZKCSHZ-UHFFFAOYSA-N butoconazole Chemical compound C1=CC(Cl)=CC=C1CCC(SC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 SWLMUYACZKCSHZ-UHFFFAOYSA-N 0.000 description 1
- 229960005074 butoconazole Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 239000003560 cancer drug Substances 0.000 description 1
- 208000035269 cancer or benign tumor Diseases 0.000 description 1
- 229960004348 candicidin Drugs 0.000 description 1
- 229960004602 capreomycin Drugs 0.000 description 1
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 1
- 229960000830 captopril Drugs 0.000 description 1
- VYFFHOFPEGQURX-UHFFFAOYSA-N carbamic acid;propane-1,2-diol Chemical compound NC(O)=O.CC(O)CO VYFFHOFPEGQURX-UHFFFAOYSA-N 0.000 description 1
- 229940041011 carbapenems Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 229960004562 carboplatin Drugs 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 229940097611 cardene Drugs 0.000 description 1
- 229940072282 cardura Drugs 0.000 description 1
- 229960005243 carmustine Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229960002165 carteolol hydrochloride Drugs 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- 229960004195 carvedilol Drugs 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 229940063628 catapres Drugs 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000003874 central nervous system depressant Substances 0.000 description 1
- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 1
- 229960005110 cerivastatin Drugs 0.000 description 1
- 229940052311 cerivastatin sodium Drugs 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- JQXXHWHPUNPDRT-YOPQJBRCSA-N chembl1332716 Chemical compound O([C@](C1=O)(C)O\C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C\C=C(C)/C(=O)NC=2C(O)=C3C(O)=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CCN(C)CC1 JQXXHWHPUNPDRT-YOPQJBRCSA-N 0.000 description 1
- 238000005234 chemical deposition Methods 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 229960004630 chlorambucil Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
- 229960000849 chlormidazole Drugs 0.000 description 1
- WNAQOLSMVPFGTE-UHFFFAOYSA-N chlormidazole Chemical compound CC1=NC2=CC=CC=C2N1CC1=CC=C(Cl)C=C1 WNAQOLSMVPFGTE-UHFFFAOYSA-N 0.000 description 1
- 229940097572 chloromycetin Drugs 0.000 description 1
- 229960003677 chloroquine Drugs 0.000 description 1
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 description 1
- ISZNZKHCRKXXAU-UHFFFAOYSA-N chlorproguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C(Cl)=C1 ISZNZKHCRKXXAU-UHFFFAOYSA-N 0.000 description 1
- 229950000764 chlorproguanil Drugs 0.000 description 1
- 239000000731 choleretic agent Substances 0.000 description 1
- 230000001989 choleretic effect Effects 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- 229940127243 cholinergic drug Drugs 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 210000004913 chyme Anatomy 0.000 description 1
- OXLKOMYHDYVIDM-UHFFFAOYSA-N ciclobendazole Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1C(=O)C1CC1 OXLKOMYHDYVIDM-UHFFFAOYSA-N 0.000 description 1
- 229960001020 ciclobendazole Drugs 0.000 description 1
- 229960003405 ciprofloxacin Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 description 1
- 229960002626 clarithromycin Drugs 0.000 description 1
- 229960002227 clindamycin Drugs 0.000 description 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
- VOGJJBHRUDVEFM-UHFFFAOYSA-N clodantoin Chemical compound CCCCC(CC)C1NC(=O)N(SC(Cl)(Cl)Cl)C1=O VOGJJBHRUDVEFM-UHFFFAOYSA-N 0.000 description 1
- 229960004208 clodantoin Drugs 0.000 description 1
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 description 1
- TXCGAZHTZHNUAI-UHFFFAOYSA-N clofibric acid Chemical compound OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 TXCGAZHTZHNUAI-UHFFFAOYSA-N 0.000 description 1
- 229950008441 clofibric acid Drugs 0.000 description 1
- BXVOHUQQUBSHLD-XCTBDMBQSA-N clomocycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(=C(/O)NCO)/C(=O)[C@@]4(O)C(=O)C3=C(O)C2=C1O BXVOHUQQUBSHLD-XCTBDMBQSA-N 0.000 description 1
- 229960004094 clomocycline Drugs 0.000 description 1
- 229960002896 clonidine Drugs 0.000 description 1
- 229960003009 clopidogrel Drugs 0.000 description 1
- 229940070395 clorpres Drugs 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 229960001152 colesevelam Drugs 0.000 description 1
- 229940097479 colestid Drugs 0.000 description 1
- GMRWGQCZJGVHKL-UHFFFAOYSA-N colestipol Chemical compound ClCC1CO1.NCCNCCNCCNCCN GMRWGQCZJGVHKL-UHFFFAOYSA-N 0.000 description 1
- 229960002604 colestipol Drugs 0.000 description 1
- 229940110933 combipres Drugs 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 229940088540 cordarone Drugs 0.000 description 1
- 229940069210 coreg Drugs 0.000 description 1
- 229940043314 corlopam Drugs 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 229940042783 corvert Drugs 0.000 description 1
- 229940103463 corzide Drugs 0.000 description 1
- 229940088547 cosmegen Drugs 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 229940116800 covera Drugs 0.000 description 1
- 229940097499 cozaar Drugs 0.000 description 1
- 229940088900 crixivan Drugs 0.000 description 1
- JHIVVAPYMSGYDF-PTQBSOBMSA-N cyclohexanone Chemical class O=[13C]1CCCCC1 JHIVVAPYMSGYDF-PTQBSOBMSA-N 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 229960000684 cytarabine Drugs 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 230000001085 cytostatic effect Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 229940018872 dalteparin sodium Drugs 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 229960004776 danaparoid sodium Drugs 0.000 description 1
- 229940099387 daranide Drugs 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 229960000975 daunorubicin Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 229940066468 demadex Drugs 0.000 description 1
- 229940099398 demser Drugs 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 239000008355 dextrose injection Substances 0.000 description 1
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 229960003807 dibekacin Drugs 0.000 description 1
- JJCQSGDBDPYCEO-XVZSLQNASA-N dibekacin Chemical compound O1[C@H](CN)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N JJCQSGDBDPYCEO-XVZSLQNASA-N 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229960003887 dichlorophen Drugs 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003866 digestant Substances 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 229940062636 digitek Drugs 0.000 description 1
- SXYIRMFQILZOAM-HVNFFKDJSA-N dihydroartemisinin methyl ether Chemical compound C1C[C@H]2[C@H](C)CC[C@H]3[C@@H](C)[C@@H](OC)O[C@H]4[C@]32OO[C@@]1(C)O4 SXYIRMFQILZOAM-HVNFFKDJSA-N 0.000 description 1
- 229960002222 dihydrostreptomycin Drugs 0.000 description 1
- ASXBYYWOLISCLQ-HZYVHMACSA-N dihydrostreptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](CO)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O ASXBYYWOLISCLQ-HZYVHMACSA-N 0.000 description 1
- 229960004166 diltiazem Drugs 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 229960001863 disopyramide phosphate Drugs 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940074654 diuril Drugs 0.000 description 1
- 229960001089 dobutamine Drugs 0.000 description 1
- 229960002994 dofetilide Drugs 0.000 description 1
- 239000003210 dopamine receptor blocking agent Substances 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 230000036267 drug metabolism Effects 0.000 description 1
- 229940018309 dyazide Drugs 0.000 description 1
- 229940089048 dyrenium Drugs 0.000 description 1
- 229940098751 edecrin Drugs 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 229940073038 elspar Drugs 0.000 description 1
- 229960000309 enalapril maleate Drugs 0.000 description 1
- 229960002680 enalaprilat Drugs 0.000 description 1
- LZFZMUMEGBBDTC-QEJZJMRPSA-N enalaprilat (anhydrous) Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 LZFZMUMEGBBDTC-QEJZJMRPSA-N 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 229960005153 enoxaparin sodium Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 229960004563 eprosartan Drugs 0.000 description 1
- 229960004468 eptifibatide Drugs 0.000 description 1
- CZKPOZZJODAYPZ-LROMGURASA-N eptifibatide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCCNC(=N)N)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]1CC1=CNC2=CC=CC=C12 CZKPOZZJODAYPZ-LROMGURASA-N 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- AVOLMBLBETYQHX-UHFFFAOYSA-N etacrynic acid Chemical compound CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl AVOLMBLBETYQHX-UHFFFAOYSA-N 0.000 description 1
- 229960003199 etacrynic acid Drugs 0.000 description 1
- QSRVZCCJDKYRRF-YDALLXLXSA-N ethyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate;hydrochloride Chemical compound Cl.CCOC(=O)[C@@](C)(N)CC1=CC=C(O)C(O)=C1 QSRVZCCJDKYRRF-YDALLXLXSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- QKODANAAHZUYET-UHFFFAOYSA-N ethylantimony Chemical compound CC[Sb] QKODANAAHZUYET-UHFFFAOYSA-N 0.000 description 1
- 229960005420 etoposide Drugs 0.000 description 1
- 239000003777 experimental drug Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- RZTAMFZIAATZDJ-UHFFFAOYSA-N felodipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-UHFFFAOYSA-N 0.000 description 1
- 229960003580 felodipine Drugs 0.000 description 1
- 229960003499 fenofibrate micronized Drugs 0.000 description 1
- 229960004009 fenoldopam mesylate Drugs 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 229950000152 filipin Drugs 0.000 description 1
- IMQSIXYSKPIGPD-NKYUYKLDSA-N filipin Chemical compound CCCCC[C@H](O)[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC1=O IMQSIXYSKPIGPD-NKYUYKLDSA-N 0.000 description 1
- IMQSIXYSKPIGPD-UHFFFAOYSA-N filipin III Natural products CCCCCC(O)C1C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C(C)=CC=CC=CC=CC=CC(O)C(C)OC1=O IMQSIXYSKPIGPD-UHFFFAOYSA-N 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 235000019374 flavomycin Nutrition 0.000 description 1
- 229960003670 flecainide acetate Drugs 0.000 description 1
- 229960003760 florfenicol Drugs 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- 229960002464 fluoxetine Drugs 0.000 description 1
- 229960000868 fluvastatin sodium Drugs 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 229960001880 fosinopril sodium Drugs 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 229940087051 fragmin Drugs 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 229960003883 furosemide Drugs 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- DNYGXMICFMACRA-UHFFFAOYSA-N gentamicin C1A Natural products O1C(CNC)CCC(N)C1OC1C(O)C(OC2C(C(NC)C(C)(O)CO2)O)C(N)CC1N DNYGXMICFMACRA-UHFFFAOYSA-N 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000004120 green S Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229960004746 guanfacine hydrochloride Drugs 0.000 description 1
- 229960003372 hachimycin Drugs 0.000 description 1
- IDWJWYPAJJDASX-GKXBZDASSA-N hachimycin Chemical compound O1C(=O)CC(=O)CC(O)CC(O)CCCC(O)CC(O)CC(O2)(O)CC(O)C(C(O)=O)C2CC(OC2C(C(N)C(O)C(C)O2)O)\C=C/C=C\C=C\C=C/C=C\C=C\C=C\C(C)C1C(C)CCC(O)CC(=O)C1=CC=C(N)C=C1 IDWJWYPAJJDASX-GKXBZDASSA-N 0.000 description 1
- 229940083463 halfprin Drugs 0.000 description 1
- 229960003242 halofantrine Drugs 0.000 description 1
- 229950006942 hamycin Drugs 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000000938 histamine H1 antagonist Substances 0.000 description 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 description 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 description 1
- 229940096120 hydrea Drugs 0.000 description 1
- 229960003313 hydroflumethiazide Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229960001330 hydroxycarbamide Drugs 0.000 description 1
- 229960004171 hydroxychloroquine Drugs 0.000 description 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 230000000055 hyoplipidemic effect Effects 0.000 description 1
- 229940090022 hyzaar Drugs 0.000 description 1
- 229940066041 ibutilide injection Drugs 0.000 description 1
- 229940099279 idamycin Drugs 0.000 description 1
- 229960000908 idarubicin Drugs 0.000 description 1
- 229940090411 ifex Drugs 0.000 description 1
- 229960001101 ifosfamide Drugs 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 229940093221 imdur Drugs 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- NDDAHWYSQHTHNT-UHFFFAOYSA-N indapamide Chemical compound CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NDDAHWYSQHTHNT-UHFFFAOYSA-N 0.000 description 1
- 229960004569 indapamide Drugs 0.000 description 1
- CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 description 1
- 150000002475 indoles Chemical class 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229940095443 innohep Drugs 0.000 description 1
- 239000004041 inotropic agent Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 230000002687 intercalation Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000002555 ionophore Substances 0.000 description 1
- 230000000236 ionophoric effect Effects 0.000 description 1
- 229950000107 ipronidazole Drugs 0.000 description 1
- 229960002198 irbesartan Drugs 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229960000798 isepamicin Drugs 0.000 description 1
- UDIIBEDMEYAVNG-ZKFPOVNWSA-N isepamicin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)O)[C@@H](N)C[C@H]1NC(=O)[C@@H](O)CN UDIIBEDMEYAVNG-ZKFPOVNWSA-N 0.000 description 1
- 229940072673 ismo Drugs 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- 229940088024 isoptin Drugs 0.000 description 1
- 229940093268 isordil Drugs 0.000 description 1
- 229960004130 itraconazole Drugs 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 229960000829 kaolin Drugs 0.000 description 1
- JUTMAMXOAOYKHT-UHFFFAOYSA-N karrikinolide Natural products C1=COC=C2OC(=O)C(C)=C21 JUTMAMXOAOYKHT-UHFFFAOYSA-N 0.000 description 1
- 229940072289 kerlone Drugs 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229960003091 labetalol hydrochloride Drugs 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 229940095570 lescol Drugs 0.000 description 1
- 229940063725 leukeran Drugs 0.000 description 1
- 229940080157 lexxel Drugs 0.000 description 1
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 1
- 229960005287 lincomycin Drugs 0.000 description 1
- 229940041028 lincosamides Drugs 0.000 description 1
- 229940002661 lipitor Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 108010033243 lisinopril drug combination hydrochlorothiazide Proteins 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 239000002171 loop diuretic Substances 0.000 description 1
- 229940063720 lopid Drugs 0.000 description 1
- 229960003088 loratadine Drugs 0.000 description 1
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 1
- 229960004773 losartan Drugs 0.000 description 1
- 229960000519 losartan potassium Drugs 0.000 description 1
- 229940080288 lotrel Drugs 0.000 description 1
- 229940118179 lovenox Drugs 0.000 description 1
- 229950005519 lucimycin Drugs 0.000 description 1
- 239000001115 mace Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 229940057948 magnesium stearate Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 229940103179 mavik Drugs 0.000 description 1
- 229940072630 maxzide Drugs 0.000 description 1
- 229960001263 mecamylamine hydrochloride Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229960005329 mefloquine hydrochloride Drugs 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229960000667 mepartricin Drugs 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 229910052752 metalloid Inorganic materials 0.000 description 1
- 150000002738 metalloids Chemical class 0.000 description 1
- VENXSELNXQXCNT-IJYXXVHRSA-N metaraminol bitartrate Chemical compound [H+].[H+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O.C[C@H](N)[C@H](O)C1=CC=CC(O)=C1 VENXSELNXQXCNT-IJYXXVHRSA-N 0.000 description 1
- 229960002984 metaraminol bitartrate Drugs 0.000 description 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 description 1
- ALPPGSBMHVCELA-WHUUVLPESA-N methyl (19E,21E,23E,25E,27E,29E,31E)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-17-[7-(4-aminophenyl)-5-hydroxy-7-oxoheptan-2-yl]-1,3,5,7,9,13,37-heptahydroxy-18-methyl-11,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate methyl (19E,21E,23E,25E,27E,29E,31E)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,7,9,13,37-heptahydroxy-17-[5-hydroxy-7-[4-(methylamino)phenyl]-7-oxoheptan-2-yl]-18-methyl-11,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate Chemical compound CC1\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C(O[C@H]2[C@H]([C@@H](N)[C@H](O)[C@@H](C)O2)O)CC(O2)C(C(=O)OC)C(O)CC2(O)CC(O)CC(O)CC(O)CC(O)CC(=O)CC(O)CC(=O)OC1C(C)CCC(O)CC(=O)C1=CC=C(N)C=C1.C1=CC(NC)=CC=C1C(=O)CC(O)CCC(C)C1C(C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C(O[C@H]2[C@H]([C@@H](N)[C@H](O)[C@@H](C)O2)O)CC(O2)C(C(=O)OC)C(O)CC2(O)CC(O)CC(O)CC(O)CC(O)CC(=O)CC(O)CC(=O)O1 ALPPGSBMHVCELA-WHUUVLPESA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960001344 methylphenidate Drugs 0.000 description 1
- 229960000939 metoprolol succinate Drugs 0.000 description 1
- 229940099246 mevacor Drugs 0.000 description 1
- 229960001070 mexiletine hydrochloride Drugs 0.000 description 1
- 229940101564 micardis Drugs 0.000 description 1
- 229960004744 micronomicin Drugs 0.000 description 1
- 229940101576 microzide Drugs 0.000 description 1
- 229940042468 midamor Drugs 0.000 description 1
- 229960001094 midodrine Drugs 0.000 description 1
- MGCQZNBCJBRZDT-UHFFFAOYSA-N midodrine hydrochloride Chemical compound [H+].[Cl-].COC1=CC=C(OC)C(C(O)CNC(=O)CN)=C1 MGCQZNBCJBRZDT-UHFFFAOYSA-N 0.000 description 1
- 229940101635 minizide Drugs 0.000 description 1
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 1
- 229960001156 mitoxantrone Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 description 1
- 230000005404 monopole Effects 0.000 description 1
- 229940118178 monopril Drugs 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000003170 musculotropic effect Effects 0.000 description 1
- 229940087525 mykrox Drugs 0.000 description 1
- GACQNVJDWUAPFY-UHFFFAOYSA-N n'-[2-[2-(2-aminoethylamino)ethylamino]ethyl]ethane-1,2-diamine;hydrochloride Chemical compound Cl.NCCNCCNCCNCCN GACQNVJDWUAPFY-UHFFFAOYSA-N 0.000 description 1
- 229960004255 nadolol Drugs 0.000 description 1
- VWPOSFSPZNDTMJ-UCWKZMIHSA-N nadolol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C VWPOSFSPZNDTMJ-UCWKZMIHSA-N 0.000 description 1
- OZGNYLLQHRPOBR-DHZHZOJOSA-N naftifine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)C\C=C\C1=CC=CC=C1 OZGNYLLQHRPOBR-DHZHZOJOSA-N 0.000 description 1
- 229960004313 naftifine Drugs 0.000 description 1
- 239000003887 narcotic antagonist Substances 0.000 description 1
- 229960003255 natamycin Drugs 0.000 description 1
- 235000010298 natamycin Nutrition 0.000 description 1
- 239000004311 natamycin Substances 0.000 description 1
- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 229960000808 netilmicin Drugs 0.000 description 1
- 239000000842 neuromuscular blocking agent Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229940033757 niaspan Drugs 0.000 description 1
- 229960001783 nicardipine Drugs 0.000 description 1
- RJMUSRYZPJIFPJ-UHFFFAOYSA-N niclosamide Chemical compound OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C([N+]([O-])=O)C=C1Cl RJMUSRYZPJIFPJ-UHFFFAOYSA-N 0.000 description 1
- 229960001920 niclosamide Drugs 0.000 description 1
- SRQKTCXJCCHINN-NYYWCZLTSA-N nifuratel Chemical compound O=C1OC(CSC)CN1\N=C\C1=CC=C([N+]([O-])=O)O1 SRQKTCXJCCHINN-NYYWCZLTSA-N 0.000 description 1
- 229960002136 nifuratel Drugs 0.000 description 1
- UIAGMCDKSXEBJQ-UHFFFAOYSA-N nimodipine Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-UHFFFAOYSA-N 0.000 description 1
- 229960000715 nimodipine Drugs 0.000 description 1
- 229940072101 nimotop Drugs 0.000 description 1
- 229960000227 nisoldipine Drugs 0.000 description 1
- 229940072981 nitro-dur Drugs 0.000 description 1
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
- 229960001907 nitrofurazone Drugs 0.000 description 1
- 229940093245 nitrolingual Drugs 0.000 description 1
- 229940073015 nitrostat Drugs 0.000 description 1
- 150000002843 nonmetals Chemical class 0.000 description 1
- 239000002664 nootropic agent Substances 0.000 description 1
- 230000001777 nootropic effect Effects 0.000 description 1
- 229940080553 normosol-m Drugs 0.000 description 1
- 229940088938 norpace Drugs 0.000 description 1
- 229940036132 norvasc Drugs 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960001027 opium Drugs 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000003534 oscillatory effect Effects 0.000 description 1
- COWNFYYYZFRNOY-UHFFFAOYSA-N oxazolidinedione Chemical compound O=C1COC(=O)N1 COWNFYYYZFRNOY-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940096689 pacerone Drugs 0.000 description 1
- QTQWMSOQOSJFBV-UHFFFAOYSA-N pamaquine Chemical compound C1=CN=C2C(NC(C)CCCN(CC)CC)=CC(OC)=CC2=C1 QTQWMSOQOSJFBV-UHFFFAOYSA-N 0.000 description 1
- 229950000466 pamaquine Drugs 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229960000339 pentamycin Drugs 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 229960002582 perindopril Drugs 0.000 description 1
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 description 1
- IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical compound CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 239000000810 peripheral vasodilating agent Substances 0.000 description 1
- 229960002116 peripheral vasodilator Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229950000688 phenothiazine Drugs 0.000 description 1
- 150000002990 phenothiazines Chemical class 0.000 description 1
- 229960003418 phenoxybenzamine Drugs 0.000 description 1
- 229960003006 phenoxybenzamine hydrochloride Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- KNCYXPMJDCCGSJ-UHFFFAOYSA-N piperidine-2,6-dione Chemical compound O=C1CCCC(=O)N1 KNCYXPMJDCCGSJ-UHFFFAOYSA-N 0.000 description 1
- 150000005458 piperidinediones Chemical class 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000007750 plasma spraying Methods 0.000 description 1
- 238000000623 plasma-assisted chemical vapour deposition Methods 0.000 description 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 1
- 229940063179 platinol Drugs 0.000 description 1
- 229940020573 plavix Drugs 0.000 description 1
- 229940090013 plendil Drugs 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229960005483 polythiazide Drugs 0.000 description 1
- 229920000046 polythiazide Polymers 0.000 description 1
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 1
- 239000003286 potassium sparing diuretic agent Substances 0.000 description 1
- 229940097241 potassium-sparing diuretic Drugs 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 238000010248 power generation Methods 0.000 description 1
- 229940089484 pravachol Drugs 0.000 description 1
- 229960001495 pravastatin sodium Drugs 0.000 description 1
- 244000062645 predators Species 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 229940089505 prilosec Drugs 0.000 description 1
- 229960005179 primaquine Drugs 0.000 description 1
- 229940088953 prinivil Drugs 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 229940117312 proamatine Drugs 0.000 description 1
- 229960000244 procainamide Drugs 0.000 description 1
- CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 1
- 229960000624 procarbazine Drugs 0.000 description 1
- 229940089949 procardia Drugs 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 description 1
- 229960005385 proguanil Drugs 0.000 description 1
- 229960002443 propafenone hydrochloride Drugs 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 230000004850 protein–protein interaction Effects 0.000 description 1
- 239000003196 psychodysleptic agent Substances 0.000 description 1
- WKSAUQYGYAYLPV-UHFFFAOYSA-N pyrimethamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1 WKSAUQYGYAYLPV-UHFFFAOYSA-N 0.000 description 1
- 229960000611 pyrimethamine Drugs 0.000 description 1
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical compound NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 description 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 1
- 229960004482 quinidine sulfate Drugs 0.000 description 1
- 229950004125 quinocide Drugs 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- 229930185107 quinolinone Natural products 0.000 description 1
- 229960003401 ramipril Drugs 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 229940099254 renese Drugs 0.000 description 1
- 229940107685 reopro Drugs 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000003169 respiratory stimulant agent Substances 0.000 description 1
- 229960003485 ribostamycin Drugs 0.000 description 1
- 229930190553 ribostamycin Natural products 0.000 description 1
- NSKGQURZWSPSBC-UHFFFAOYSA-N ribostamycin A Natural products NC1C(O)C(O)C(CN)OC1OC1C(OC2C(C(O)C(CO)O2)O)C(O)C(N)CC1N NSKGQURZWSPSBC-UHFFFAOYSA-N 0.000 description 1
- NSKGQURZWSPSBC-VVPCINPTSA-R ribostamycin(4+) Chemical compound [NH3+][C@@H]1[C@@H](O)[C@H](O)[C@@H](C[NH3+])O[C@@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H]([NH3+])C[C@@H]1[NH3+] NSKGQURZWSPSBC-VVPCINPTSA-R 0.000 description 1
- 229950003104 rifamide Drugs 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 229960003292 rifamycin Drugs 0.000 description 1
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 description 1
- VFYNXKZVOUXHDX-VDPUEHCXSA-N rifamycin b diethylamide Chemical compound CC1=C(O)C(C=2O)=C3C(OCC(=O)N(CC)CC)=CC=2NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]2(C)OC1=C3C2=O VFYNXKZVOUXHDX-VDPUEHCXSA-N 0.000 description 1
- WDZCUPBHRAEYDL-GZAUEHORSA-N rifapentine Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C(O)=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N(CC1)CCN1C1CCCC1 WDZCUPBHRAEYDL-GZAUEHORSA-N 0.000 description 1
- 229960002599 rifapentine Drugs 0.000 description 1
- 229960003040 rifaximin Drugs 0.000 description 1
- NZCRJKRKKOLAOJ-XRCRFVBUSA-N rifaximin Chemical compound OC1=C(C(O)=C2C)C3=C4N=C5C=C(C)C=CN5C4=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O NZCRJKRKKOLAOJ-XRCRFVBUSA-N 0.000 description 1
- 229940018498 rythmol Drugs 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 229960005456 sisomicin Drugs 0.000 description 1
- URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- KYITYFHKDODNCQ-UHFFFAOYSA-M sodium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [Na+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 KYITYFHKDODNCQ-UHFFFAOYSA-M 0.000 description 1
- IIZQYKZCLMEPBU-UHFFFAOYSA-N sodium;6-chloro-1,2,4-benzothiadiazin-2-ide-7-sulfonamide Chemical compound S1N([Na])C=NC2=C1C=C(S(=O)(=O)N)C(Cl)=C2 IIZQYKZCLMEPBU-UHFFFAOYSA-N 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940093252 sorbitrate Drugs 0.000 description 1
- 229960003579 sotalol hydrochloride Drugs 0.000 description 1
- 229960000268 spectinomycin Drugs 0.000 description 1
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 229940035718 sular Drugs 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 description 1
- 229960005314 suramin Drugs 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229940106719 tambocor Drugs 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940001587 tarka Drugs 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 229960005187 telmisartan Drugs 0.000 description 1
- 229960000216 tenecteplase Drugs 0.000 description 1
- 229940065385 tenex Drugs 0.000 description 1
- 229940015900 tenoretic Drugs 0.000 description 1
- 229940108485 tenormin Drugs 0.000 description 1
- 229960001909 terazosin hydrochloride Drugs 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
- 229940078806 teveten Drugs 0.000 description 1
- 229940088012 thalitone Drugs 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 150000004897 thiazines Chemical class 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 229940035248 tiazac Drugs 0.000 description 1
- 229940028869 ticlid Drugs 0.000 description 1
- 229960005001 ticlopidine Drugs 0.000 description 1
- MTKNGOHFNXIVOS-UHFFFAOYSA-N ticlopidine hydrochloride Chemical compound [H+].[Cl-].ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 MTKNGOHFNXIVOS-UHFFFAOYSA-N 0.000 description 1
- 229960002961 ticlopidine hydrochloride Drugs 0.000 description 1
- 229940061437 tikosyn Drugs 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 229960005221 timolol maleate Drugs 0.000 description 1
- SYRHIZPPCHMRIT-UHFFFAOYSA-N tin(4+) Chemical compound [Sn+4] SYRHIZPPCHMRIT-UHFFFAOYSA-N 0.000 description 1
- 229940064689 tinzaparin sodium Drugs 0.000 description 1
- HWAAPJPFZPHHBC-FGJQBABTSA-N tirofiban hydrochloride Chemical compound O.Cl.C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 HWAAPJPFZPHHBC-FGJQBABTSA-N 0.000 description 1
- 229960004929 tirofiban hydrochloride Drugs 0.000 description 1
- 229940113038 tnkase Drugs 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-S tobramycin(5+) Chemical compound [NH3+][C@@H]1C[C@H](O)[C@@H](C[NH3+])O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H]([NH3+])[C@H](O)[C@@H](CO)O2)O)[C@H]([NH3+])C[C@@H]1[NH3+] NLVFBUXFDBBNBW-PBSUHMDJSA-S 0.000 description 1
- BUJAGSGYPOAWEI-UHFFFAOYSA-N tocainide Chemical compound CC(N)C(=O)NC1=C(C)C=CC=C1C BUJAGSGYPOAWEI-UHFFFAOYSA-N 0.000 description 1
- 229960002872 tocainide Drugs 0.000 description 1
- 229960003916 tolciclate Drugs 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229940041492 toprol Drugs 0.000 description 1
- 229960005461 torasemide Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229960002051 trandolapril Drugs 0.000 description 1
- 229940125725 tranquilizer Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229960001288 triamterene Drugs 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 229940055755 tricor Drugs 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- 229950000976 trospectomycin Drugs 0.000 description 1
- KHAUBYTYGDOYRU-IRXASZMISA-N trospectomycin Chemical compound CN[C@H]([C@H]1O2)[C@@H](O)[C@@H](NC)[C@H](O)[C@H]1O[C@H]1[C@]2(O)C(=O)C[C@@H](CCCC)O1 KHAUBYTYGDOYRU-IRXASZMISA-N 0.000 description 1
- 229940054506 uniretic Drugs 0.000 description 1
- 229940054495 univasc Drugs 0.000 description 1
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 229960004699 valsartan Drugs 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 229940032178 vaseretic Drugs 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 229940099270 vasotec Drugs 0.000 description 1
- 229940055010 verelan Drugs 0.000 description 1
- 229940094720 viagra Drugs 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000001757 vomitory effect Effects 0.000 description 1
- 229960002647 warfarin sodium Drugs 0.000 description 1
- 229940111503 welchol Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
- 229940053890 zanosar Drugs 0.000 description 1
- 229940087514 zaroxolyn Drugs 0.000 description 1
- 229940052204 zebeta Drugs 0.000 description 1
- 229940063159 zestoretic Drugs 0.000 description 1
- 229940072252 zestril Drugs 0.000 description 1
- 229940117978 ziac Drugs 0.000 description 1
- 229940072168 zocor Drugs 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0026—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the transmission medium
- A61B5/0028—Body tissue as transmission medium, i.e. transmission systems where the medium is the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/076—Permanent implantations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4833—Assessment of subject's compliance to treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6861—Capsules, e.g. for swallowing or implanting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7282—Event detection, e.g. detecting unique waveforms indicative of a medical condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/007—Marking tablets or the like
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K7/00—Methods or arrangements for sensing record carriers, e.g. for reading patterns
- G06K7/10—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation
- G06K7/10009—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation sensing by radiation using wavelengths larger than 0.1 mm, e.g. radio-waves or microwaves
- G06K7/10158—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation sensing by radiation using wavelengths larger than 0.1 mm, e.g. radio-waves or microwaves methods and means used by the interrogation device for reliably powering the wireless record carriers using an electromagnetic interrogation field
- G06K7/10168—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation sensing by radiation using wavelengths larger than 0.1 mm, e.g. radio-waves or microwaves methods and means used by the interrogation device for reliably powering the wireless record carriers using an electromagnetic interrogation field the powering being adversely affected by environmental influences, e.g. unwanted energy loss in the interrogation signal due to metallic or capacitive objects in the proximity of the interrogation device or in the proximity of the interrogated record carrier
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K7/00—Methods or arrangements for sensing record carriers, e.g. for reading patterns
- G06K7/10—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation
- G06K7/10009—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation sensing by radiation using wavelengths larger than 0.1 mm, e.g. radio-waves or microwaves
- G06K7/10366—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation sensing by radiation using wavelengths larger than 0.1 mm, e.g. radio-waves or microwaves the interrogation device being adapted for miscellaneous applications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01Q—ANTENNAS, i.e. RADIO AERIALS
- H01Q1/00—Details of, or arrangements associated with, antennas
- H01Q1/27—Adaptation for use in or on movable bodies
- H01Q1/273—Adaptation for carrying or wearing by persons or animals
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B13/00—Transmission systems characterised by the medium used for transmission, not provided for in groups H04B3/00 - H04B11/00
- H04B13/005—Transmission systems in which the medium consists of the human body
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W4/00—Services specially adapted for wireless communication networks; Facilities therefor
- H04W4/80—Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0204—Operational features of power management
- A61B2560/0214—Operational features of power management of power generation or supply
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
- A61B2560/0462—Apparatus with built-in sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/08—Sensors provided with means for identification, e.g. barcodes or memory chips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
- A61B2562/162—Capsule shaped sensor housings, e.g. for swallowing or implantation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
- Y10T29/49117—Conductor or circuit manufacturing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Computer Networks & Wireless Communication (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Signal Processing (AREA)
- Electromagnetism (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Artificial Intelligence (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Theoretical Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Accommodation For Nursing Or Treatment Tables (AREA)
Abstract
Description
Claims (8)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67614505P | 2005-04-28 | 2005-04-28 | |
US60/676145 | 2005-04-28 | ||
US69407805P | 2005-06-24 | 2005-06-24 | |
US60/694078 | 2005-06-24 | ||
US71368005P | 2005-09-01 | 2005-09-01 | |
US60/713680 | 2005-09-01 | ||
US79033506P | 2006-04-07 | 2006-04-07 | |
US60/790335 | 2006-04-07 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800238386A Division CN101287411B (zh) | 2005-04-28 | 2006-04-28 | 药物信息系统及其用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102379684A CN102379684A (zh) | 2012-03-21 |
CN102379684B true CN102379684B (zh) | 2014-11-19 |
Family
ID=37215570
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800238386A Active CN101287411B (zh) | 2005-04-28 | 2006-04-28 | 药物信息系统及其用途 |
CN201110212586.4A Active CN102379684B (zh) | 2005-04-28 | 2006-04-28 | 药物信息系统 |
CN2013100090910A Pending CN103259027A (zh) | 2005-04-28 | 2006-04-28 | 药物信息系统 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800238386A Active CN101287411B (zh) | 2005-04-28 | 2006-04-28 | 药物信息系统及其用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2013100090910A Pending CN103259027A (zh) | 2005-04-28 | 2006-04-28 | 药物信息系统 |
Country Status (14)
Country | Link |
---|---|
US (17) | US8847766B2 (zh) |
EP (5) | EP2392258B1 (zh) |
JP (6) | JP2008539047A (zh) |
CN (3) | CN101287411B (zh) |
AU (1) | AU2006239221C1 (zh) |
CA (3) | CA2789262C (zh) |
DK (1) | DK1889198T3 (zh) |
ES (1) | ES2528403T3 (zh) |
HK (2) | HK1113652A1 (zh) |
IL (7) | IL186898A (zh) |
PL (1) | PL1889198T3 (zh) |
PT (1) | PT1889198E (zh) |
SI (1) | SI1889198T1 (zh) |
WO (1) | WO2006116718A2 (zh) |
Families Citing this family (253)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7414534B1 (en) | 2004-11-09 | 2008-08-19 | Pacesetter, Inc. | Method and apparatus for monitoring ingestion of medications using an implantable medical device |
US8730031B2 (en) | 2005-04-28 | 2014-05-20 | Proteus Digital Health, Inc. | Communication system using an implantable device |
US9198608B2 (en) * | 2005-04-28 | 2015-12-01 | Proteus Digital Health, Inc. | Communication system incorporated in a container |
US20120004520A1 (en) * | 2005-04-28 | 2012-01-05 | Proteus Biomedical, Inc. | Communication System with Multiple Sources of Power |
EP2392258B1 (en) * | 2005-04-28 | 2014-10-08 | Proteus Digital Health, Inc. | Pharma-informatics system |
US8912908B2 (en) | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US8836513B2 (en) | 2006-04-28 | 2014-09-16 | Proteus Digital Health, Inc. | Communication system incorporated in an ingestible product |
US7888125B2 (en) | 2005-05-09 | 2011-02-15 | Theranos, Inc. | Calibration of fluidic devices |
WO2007028035A2 (en) | 2005-09-01 | 2007-03-08 | Proteus Biomedical, Inc. | Implantable zero-wire communications system |
EP1770603A1 (en) * | 2005-10-03 | 2007-04-04 | Assa Abloy Identification Technology Group AB | Encapsulated transponder and method for manufacturing the same |
US8920343B2 (en) | 2006-03-23 | 2014-12-30 | Michael Edward Sabatino | Apparatus for acquiring and processing of physiological auditory signals |
US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
CN105468895A (zh) | 2006-05-02 | 2016-04-06 | 普罗透斯数字保健公司 | 患者定制的治疗方案 |
US20080027348A1 (en) | 2006-06-23 | 2008-01-31 | Neuro Vista Corporation | Minimally Invasive Monitoring Systems for Monitoring a Patient's Propensity for a Neurological Event |
JP5241714B2 (ja) | 2006-07-07 | 2013-07-17 | プロテウス デジタル ヘルス, インコーポレイテッド | スマートな非経口送達システム |
US20080020037A1 (en) * | 2006-07-11 | 2008-01-24 | Robertson Timothy L | Acoustic Pharma-Informatics System |
WO2008030480A2 (en) | 2006-09-06 | 2008-03-13 | Innurvation, Inc. | Ingestible low power sensor device and system for communicating with same |
US8615284B2 (en) | 2006-09-06 | 2013-12-24 | Innurvation, Inc. | Method for acoustic information exchange involving an ingestible low power capsule |
CN101522094B (zh) * | 2006-09-29 | 2013-12-18 | 皇家飞利浦电子股份有限公司 | 微型化阈值传感器 |
WO2008066617A2 (en) | 2006-10-17 | 2008-06-05 | Proteus Biomedical, Inc. | Low voltage oscillator for medical devices |
US9622216B2 (en) * | 2006-10-20 | 2017-04-11 | Avago Technologies General Ip (Singapore) Ptd. Ltd | Method and system for low rate MAC/PHY for 60 GHz transmission |
EP2083680B1 (en) | 2006-10-25 | 2016-08-10 | Proteus Digital Health, Inc. | Controlled activation ingestible identifier |
EP2069004A4 (en) | 2006-11-20 | 2014-07-09 | Proteus Digital Health Inc | PERSONAL HEALTH SIGNAL RECEIVERS WITH ACTIVE SIGNAL PROCESSING |
AU2012247015B2 (en) * | 2007-02-01 | 2015-09-17 | Otsuka Pharmaceutical Co., Ltd. | Ingestible event marker systems |
MY165532A (en) | 2007-02-01 | 2018-04-02 | Proteus Digital Health Inc | Ingestible event marker systems |
US20100144268A1 (en) * | 2007-02-14 | 2010-06-10 | Kaba Ag | System and portable device for transmitting identification signals |
CA2676280C (en) | 2007-02-14 | 2018-05-22 | Proteus Biomedical, Inc. | In-body power source having high surface area electrode |
AU2012244231B2 (en) * | 2007-02-14 | 2014-09-18 | Otsuka Pharmaceutical Co., Ltd. | In-body power source having high surface area electrode |
US9270025B2 (en) | 2007-03-09 | 2016-02-23 | Proteus Digital Health, Inc. | In-body device having deployable antenna |
EP2124725A1 (en) * | 2007-03-09 | 2009-12-02 | Proteus Biomedical, Inc. | In-body device having a multi-directional transmitter |
US8540632B2 (en) | 2007-05-24 | 2013-09-24 | Proteus Digital Health, Inc. | Low profile antenna for in body device |
DK2192946T3 (da) | 2007-09-25 | 2022-11-21 | Otsuka Pharma Co Ltd | Kropsintern anordning med virtuel dipol signalforstærkning |
US20090088618A1 (en) * | 2007-10-01 | 2009-04-02 | Arneson Michael R | System and Method for Manufacturing a Swallowable Sensor Device |
SG10201606120XA (en) | 2007-10-02 | 2016-09-29 | Theranos Inc | Modular Point-Of-Care Devices And Uses Thereof |
US9125979B2 (en) | 2007-10-25 | 2015-09-08 | Proteus Digital Health, Inc. | Fluid transfer port information system |
WO2009067463A1 (en) | 2007-11-19 | 2009-05-28 | Proteus Biomedical, Inc. | Body-associated fluid transport structure evaluation devices |
ES2661739T3 (es) | 2007-11-27 | 2018-04-03 | Proteus Digital Health, Inc. | Sistemas de comunicación transcorporal que emplean canales de comunicación |
MY161533A (en) * | 2008-03-05 | 2017-04-28 | Proteus Digital Health Inc | Multi-mode communication ingestible event markers and systems, and methods of using the same |
US20100280366A1 (en) * | 2008-05-13 | 2010-11-04 | Lawrence Arne | Continuous field tomography systems and methods of using the same |
EP2310987A4 (en) * | 2008-07-03 | 2011-09-14 | Mario W Cardullo | NANO RFID METHOD AND DEVICE |
WO2010005953A2 (en) * | 2008-07-07 | 2010-01-14 | Cardullo Mario W | Dynamically distributable nano rfid device and related method |
SG195535A1 (en) | 2008-07-08 | 2013-12-30 | Proteus Digital Health Inc | Ingestible event marker data framework |
EP2313851A2 (en) * | 2008-07-11 | 2011-04-27 | Mario W. Cardullo | Dynamically triggerable nano rfid device and related method |
JP5653918B2 (ja) | 2008-07-30 | 2015-01-14 | エコーレ ポリテクニーク フェデラーレ デ ローザンヌ (イーピーエフエル) | 神経標的の最適化された刺激のための装置および方法 |
EP2341814B1 (en) | 2008-08-11 | 2017-03-15 | Nxp B.V. | Ingestible devices for measuring physiological parameters |
KR101214453B1 (ko) * | 2008-08-13 | 2012-12-24 | 프로테우스 디지털 헬스, 인코포레이티드 | 복용 가능한 회로 |
US20100068283A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex VIVO modifiable particle or polymeric material medicament carrier |
US20100068275A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Personalizable dosage form |
US20100069821A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo modifiable medicament release-sites final dosage form |
US20100068153A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo activatable final dosage form |
US20100068152A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo modifiable particle or polymeric based final dosage form |
US20100068233A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Modifiable dosage form |
US20100068235A1 (en) * | 2008-09-16 | 2010-03-18 | Searete LLC, a limited liability corporation of Deleware | Individualizable dosage form |
US20100069887A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Multiple chamber ex vivo adjustable-release final dosage form |
US20100068254A1 (en) * | 2008-09-16 | 2010-03-18 | Mahalaxmi Gita Bangera | Modifying a medicament availability state of a final dosage form |
US8159347B2 (en) * | 2008-09-25 | 2012-04-17 | General Electric Company | Sensors having gap based sensing devices and methods of making and using the same |
JP2012505717A (ja) * | 2008-10-14 | 2012-03-08 | プロテウス バイオメディカル インコーポレイテッド | ゲーム環境に生理学的データを組み込む方法およびシステム |
EP3563902B1 (en) | 2008-11-12 | 2021-07-14 | Ecole Polytechnique Fédérale de Lausanne | Microfabricated neurostimulation device |
WO2010057049A2 (en) * | 2008-11-13 | 2010-05-20 | Proteus Biomedical, Inc. | Ingestible therapy activator system and method |
CN102271578B (zh) * | 2008-12-11 | 2013-12-04 | 普罗秋斯数字健康公司 | 使用便携式电子内脏造影系统的胃肠功能的评估及其使用方法 |
TWI424832B (zh) | 2008-12-15 | 2014-02-01 | Proteus Digital Health Inc | 與身體有關的接收器及其方法 |
US9439566B2 (en) | 2008-12-15 | 2016-09-13 | Proteus Digital Health, Inc. | Re-wearable wireless device |
US9659423B2 (en) | 2008-12-15 | 2017-05-23 | Proteus Digital Health, Inc. | Personal authentication apparatus system and method |
US8830037B2 (en) * | 2008-12-31 | 2014-09-09 | The Regents Of The University Of California | In vivo RFID chip |
TWI602561B (zh) | 2009-01-06 | 2017-10-21 | 波提亞斯數位康健公司 | 醫藥劑量傳送系統 |
CA2750151A1 (en) * | 2009-01-06 | 2010-07-15 | Proteus Biomedical, Inc. | High-throughput production of ingestible event markers |
AU2010203625A1 (en) | 2009-01-06 | 2011-07-21 | Proteus Digital Health, Inc. | Ingestion-related biofeedback and personalized medical therapy method and system |
WO2010111403A2 (en) * | 2009-03-25 | 2010-09-30 | Proteus Biomedical, Inc. | Probablistic pharmacokinetic and pharmacodynamic modeling |
CN102458236B (zh) | 2009-04-28 | 2016-01-27 | 普罗秋斯数字健康公司 | 高可靠性的可摄入事件标记器及其使用方法 |
WO2010132331A2 (en) | 2009-05-12 | 2010-11-18 | Proteus Biomedical, Inc. | Ingestible event markers comprising an ingestible component |
US8786049B2 (en) * | 2009-07-23 | 2014-07-22 | Proteus Digital Health, Inc. | Solid-state thin-film capacitor |
US8558563B2 (en) | 2009-08-21 | 2013-10-15 | Proteus Digital Health, Inc. | Apparatus and method for measuring biochemical parameters |
TWI517050B (zh) * | 2009-11-04 | 2016-01-11 | 普羅托斯數位健康公司 | 供應鏈管理之系統 |
CA2782710C (en) | 2009-12-01 | 2019-01-22 | Ecole Polytechnique Federale De Lausanne | Microfabricated neurostimulation device and methods of making and using the same |
UA109424C2 (uk) * | 2009-12-02 | 2015-08-25 | Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки | |
CN102724907A (zh) * | 2010-01-27 | 2012-10-10 | 奥林巴斯株式会社 | 电源系统以及搭载该电源系统的医疗用胶囊装置 |
JP5841951B2 (ja) | 2010-02-01 | 2016-01-13 | プロテウス デジタル ヘルス, インコーポレイテッド | データ収集システム |
CN102905612A (zh) | 2010-02-01 | 2013-01-30 | 普罗秋斯数字健康公司 | 双腕式数据采集系统 |
EP2552378B1 (en) * | 2010-03-29 | 2016-04-20 | Ethimedix S.A. | Secure liquid drug dispenser and method for delivering liquid medication |
JP5927176B2 (ja) | 2010-04-01 | 2016-06-01 | エコーレ ポリテクニーク フェデラーレ デ ローザンヌ (イーピーエフエル) | 神経組織と相互作用するためのデバイス、ならびにそれを作製および使用する方法 |
WO2011127252A2 (en) * | 2010-04-07 | 2011-10-13 | Proteus Biomedical, Inc. | Miniature ingestible device |
EP2557986A4 (en) * | 2010-04-11 | 2014-01-22 | Proteus Digital Health Inc | APPARATUS, SYSTEM AND METHOD FOR DETECTION AND ADMINISTRATION OF MEDICINAL DOSE |
TWI557672B (zh) | 2010-05-19 | 2016-11-11 | 波提亞斯數位康健公司 | 用於從製造商跟蹤藥物直到患者之電腦系統及電腦實施之方法、用於確認將藥物給予患者的設備及方法、患者介面裝置 |
US10342444B2 (en) * | 2010-06-08 | 2019-07-09 | Alivecor, Inc. | Mobile ECG sensor apparatus |
EP2580687A4 (en) * | 2010-06-14 | 2014-04-30 | Trutag Technologies Inc | SYSTEM FOR CHECKING AN ELEMENT IN A PACKAGE WITH A DATABASE |
AP2013006667A0 (en) | 2010-07-12 | 2013-01-31 | Therasyn Sensors Inc | A device and methods for in vivo monitoring of an individual |
US20120203573A1 (en) | 2010-09-22 | 2012-08-09 | I.D. Therapeutics Llc | Methods, systems, and apparatus for optimizing effects of treatment with medication using medication compliance patterns |
US20120089417A1 (en) | 2010-10-08 | 2012-04-12 | Bardy Gust H | Computer-Implemented System And Method For Mediating Patient-Initiated Physiological Monitoring |
US20120089412A1 (en) | 2010-10-08 | 2012-04-12 | Bardy Gust H | Computer-Implemented System And Method For Facilitating Patient Advocacy Through Online Healthcare Provisioning |
US8285370B2 (en) | 2010-10-08 | 2012-10-09 | Cardiac Science Corporation | Microcontrolled electrocardiographic monitoring circuit with feedback control |
US8239012B2 (en) | 2010-10-08 | 2012-08-07 | Cardiac Science Corporation | Microcontrolled electrocardiographic monitoring circuit with differential voltage encoding |
US9037477B2 (en) | 2010-10-08 | 2015-05-19 | Cardiac Science Corporation | Computer-implemented system and method for evaluating ambulatory electrocardiographic monitoring of cardiac rhythm disorders |
US20120089001A1 (en) | 2010-10-08 | 2012-04-12 | Jon Mikalson Bishay | Ambulatory Electrocardiographic Monitor And Method Of Use |
US20120089000A1 (en) | 2010-10-08 | 2012-04-12 | Jon Mikalson Bishay | Ambulatory Electrocardiographic Monitor For Providing Ease Of Use In Women And Method Of Use |
US8613708B2 (en) | 2010-10-08 | 2013-12-24 | Cardiac Science Corporation | Ambulatory electrocardiographic monitor with jumpered sensing electrode |
JP5734614B2 (ja) * | 2010-10-08 | 2015-06-17 | オリンパス株式会社 | 生体情報取得装置 |
JP2014504902A (ja) * | 2010-11-22 | 2014-02-27 | プロテウス デジタル ヘルス, インコーポレイテッド | 医薬品を有する摂取可能なデバイス |
UA109691C2 (uk) * | 2010-12-29 | 2015-09-25 | Бездротові джерела енергії для використання в інтегральних схемах | |
AU2012205777A1 (en) | 2011-01-10 | 2013-08-01 | Proteus Digital Health, Inc. | System, method, and article to prompt behavior change |
CN106248582B (zh) | 2011-01-21 | 2020-10-20 | 拉布拉多诊断有限责任公司 | 样品使用最大化的系统和方法 |
US9439599B2 (en) | 2011-03-11 | 2016-09-13 | Proteus Digital Health, Inc. | Wearable personal body associated device with various physical configurations |
EP2688559B1 (en) * | 2011-03-24 | 2018-05-09 | STOCO 10 GmbH | Swallowable medication capsule |
US20120259376A1 (en) * | 2011-04-08 | 2012-10-11 | Empire Technology Development Llc | Charge Storage System |
WO2012138354A1 (en) * | 2011-04-08 | 2012-10-11 | Empire Technology Development Llc | Moisture activated battery |
US8744593B2 (en) | 2011-04-08 | 2014-06-03 | Empire Technology Development Llc | Gel formed battery |
US8735001B2 (en) | 2011-04-08 | 2014-05-27 | Empire Technology Development Llc | Gel formed battery |
US8828581B2 (en) | 2011-04-08 | 2014-09-09 | Empire Technology Development Llc | Liquid battery formed from encapsulated components |
US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
BR112014001397A2 (pt) * | 2011-07-21 | 2017-02-21 | Proteus Biomedical Inc | dispositivo, sistema e método de comunicação móvel |
EP2748685A4 (en) | 2011-08-27 | 2015-05-20 | Daniel L Kraft | PORTABLE MEDICINAL DISPENSER |
US9619627B2 (en) | 2011-09-25 | 2017-04-11 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US9268915B2 (en) | 2011-09-25 | 2016-02-23 | Theranos, Inc. | Systems and methods for diagnosis or treatment |
US8840838B2 (en) | 2011-09-25 | 2014-09-23 | Theranos, Inc. | Centrifuge configurations |
US8380541B1 (en) | 2011-09-25 | 2013-02-19 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
US9250229B2 (en) | 2011-09-25 | 2016-02-02 | Theranos, Inc. | Systems and methods for multi-analysis |
US9235683B2 (en) | 2011-11-09 | 2016-01-12 | Proteus Digital Health, Inc. | Apparatus, system, and method for managing adherence to a regimen |
US20140315170A1 (en) * | 2011-11-23 | 2014-10-23 | Proteus Digital Health, Inc. | Apparatus, System, and Method to Promote Behavior Change Based on Mindfulness Methodologies |
US20130129869A1 (en) * | 2011-11-23 | 2013-05-23 | Hooman Hafezi | Compositions comprising a shelf-life stability component |
WO2013165961A1 (en) | 2012-04-30 | 2013-11-07 | Bettinger, Christopher J. | A water-activated, ingestible battery |
US9770588B2 (en) | 2012-04-30 | 2017-09-26 | Carnegie Mellon University | Ingestible, electrical device for stimulating tissues in a gastrointestinal tract of an organism |
EP2659834A1 (en) * | 2012-04-30 | 2013-11-06 | Siemens Aktiengesellschaft | Costoptimized Hp capsule |
WO2014018454A1 (en) | 2012-07-23 | 2014-01-30 | Proteus Digital Health, Inc. | Techniques for manufacturing ingestible event markers comprising an ingestible component |
US11737896B2 (en) | 2012-07-31 | 2023-08-29 | Purdue Research Foundation | Wirelessly-powered implantable EMG recording system |
US8761717B1 (en) | 2012-08-07 | 2014-06-24 | Brian K. Buchheit | Safety feature to disable an electronic device when a wireless implantable medical device (IMD) is proximate |
JP5869736B2 (ja) | 2012-10-18 | 2016-02-24 | プロテウス デジタル ヘルス, インコーポレイテッド | 通信デバイス用の電源において電力消失およびブロードキャスト電力を適応的に最適化するための装置、システム、および方法 |
WO2014071571A1 (en) * | 2012-11-07 | 2014-05-15 | Empire Technology Development Llc | Liquid-activated hydrogel battery |
SG11201504844SA (en) | 2012-12-19 | 2015-07-30 | Otsuka Pharma Co Ltd | Medical tablet, and manufacturing method and manufacturing apparatus for medical tablet |
US20140324216A1 (en) * | 2013-01-24 | 2014-10-30 | Sami A Beg | Method, system and apparatus for managing medication delivery |
TWI659994B (zh) | 2013-01-29 | 2019-05-21 | 美商普羅托斯數位健康公司 | 高度可膨脹之聚合型薄膜及包含彼之組成物 |
KR101381424B1 (ko) | 2013-01-31 | 2014-04-14 | 계명대학교 산학협력단 | 삽입형 무선 심전도 센서 장치 |
MX354033B (es) | 2013-02-18 | 2018-02-09 | Theranos Ip Co Llc | Sistemas y métodos para recolectar y transmitir resultados de ensayos. |
US20140283017A1 (en) | 2013-03-13 | 2014-09-18 | Motorola Mobility Llc | Communicating via a body-area network |
WO2014151925A1 (en) * | 2013-03-15 | 2014-09-25 | Proteus Digital Health, Inc. | Re-wearable wireless device |
GB201304738D0 (en) * | 2013-03-15 | 2013-05-01 | Mars Inc | Sampling Device |
WO2014151929A1 (en) | 2013-03-15 | 2014-09-25 | Proteus Digital Health, Inc. | Personal authentication apparatus system and method |
US20140278468A1 (en) | 2013-03-15 | 2014-09-18 | I.D. Therapeutics Llc | Apparatus and method for optimizing treatment using medication compliance patterns and glucose sensor |
JP5941240B2 (ja) | 2013-03-15 | 2016-06-29 | プロテウス デジタル ヘルス, インコーポレイテッド | 金属検出器装置、システム、および方法 |
JP6511439B2 (ja) | 2013-06-04 | 2019-05-15 | プロテウス デジタル ヘルス, インコーポレイテッド | データ収集および転帰の査定のためのシステム、装置、および方法 |
DE202013005125U1 (de) * | 2013-06-04 | 2014-09-05 | Hugo Vogelsang Maschinenbau Gmbh | Vorrichtung zur elektrischen Desintegration von Zellverbänden |
US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
AU2014321320B2 (en) | 2013-09-20 | 2019-03-14 | Otsuka Pharmaceutical Co., Ltd. | Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping |
WO2015044722A1 (en) | 2013-09-24 | 2015-04-02 | Proteus Digital Health, Inc. | Method and apparatus for use with received electromagnetic signal at a frequency not known exactly in advance |
US9717432B2 (en) | 2013-09-25 | 2017-08-01 | Bardy Diagnostics, Inc. | Extended wear electrocardiography patch using interlaced wire electrodes |
US10463269B2 (en) | 2013-09-25 | 2019-11-05 | Bardy Diagnostics, Inc. | System and method for machine-learning-based atrial fibrillation detection |
US20190167139A1 (en) | 2017-12-05 | 2019-06-06 | Gust H. Bardy | Subcutaneous P-Wave Centric Insertable Cardiac Monitor For Long Term Electrocardiographic Monitoring |
US9545204B2 (en) | 2013-09-25 | 2017-01-17 | Bardy Diagnostics, Inc. | Extended wear electrocardiography patch |
US11723575B2 (en) | 2013-09-25 | 2023-08-15 | Bardy Diagnostics, Inc. | Electrocardiography patch |
US10888239B2 (en) | 2013-09-25 | 2021-01-12 | Bardy Diagnostics, Inc. | Remote interfacing electrocardiography patch |
US10806360B2 (en) | 2013-09-25 | 2020-10-20 | Bardy Diagnostics, Inc. | Extended wear ambulatory electrocardiography and physiological sensor monitor |
US9700227B2 (en) | 2013-09-25 | 2017-07-11 | Bardy Diagnostics, Inc. | Ambulatory electrocardiography monitoring patch optimized for capturing low amplitude cardiac action potential propagation |
US9655537B2 (en) | 2013-09-25 | 2017-05-23 | Bardy Diagnostics, Inc. | Wearable electrocardiography and physiology monitoring ensemble |
US10165946B2 (en) | 2013-09-25 | 2019-01-01 | Bardy Diagnostics, Inc. | Computer-implemented system and method for providing a personal mobile device-triggered medical intervention |
US9433380B1 (en) | 2013-09-25 | 2016-09-06 | Bardy Diagnostics, Inc. | Extended wear electrocardiography patch |
US9655538B2 (en) | 2013-09-25 | 2017-05-23 | Bardy Diagnostics, Inc. | Self-authenticating electrocardiography monitoring circuit |
US9345414B1 (en) | 2013-09-25 | 2016-05-24 | Bardy Diagnostics, Inc. | Method for providing dynamic gain over electrocardiographic data with the aid of a digital computer |
US10667711B1 (en) | 2013-09-25 | 2020-06-02 | Bardy Diagnostics, Inc. | Contact-activated extended wear electrocardiography and physiological sensor monitor recorder |
US9364155B2 (en) | 2013-09-25 | 2016-06-14 | Bardy Diagnostics, Inc. | Self-contained personal air flow sensing monitor |
US9615763B2 (en) | 2013-09-25 | 2017-04-11 | Bardy Diagnostics, Inc. | Ambulatory electrocardiography monitor recorder optimized for capturing low amplitude cardiac action potential propagation |
US10799137B2 (en) | 2013-09-25 | 2020-10-13 | Bardy Diagnostics, Inc. | System and method for facilitating a cardiac rhythm disorder diagnosis with the aid of a digital computer |
US9408551B2 (en) | 2013-11-14 | 2016-08-09 | Bardy Diagnostics, Inc. | System and method for facilitating diagnosis of cardiac rhythm disorders with the aid of a digital computer |
US10624551B2 (en) | 2013-09-25 | 2020-04-21 | Bardy Diagnostics, Inc. | Insertable cardiac monitor for use in performing long term electrocardiographic monitoring |
US10820801B2 (en) | 2013-09-25 | 2020-11-03 | Bardy Diagnostics, Inc. | Electrocardiography monitor configured for self-optimizing ECG data compression |
US10433751B2 (en) | 2013-09-25 | 2019-10-08 | Bardy Diagnostics, Inc. | System and method for facilitating a cardiac rhythm disorder diagnosis based on subcutaneous cardiac monitoring data |
US10433748B2 (en) | 2013-09-25 | 2019-10-08 | Bardy Diagnostics, Inc. | Extended wear electrocardiography and physiological sensor monitor |
US10736531B2 (en) | 2013-09-25 | 2020-08-11 | Bardy Diagnostics, Inc. | Subcutaneous insertable cardiac monitor optimized for long term, low amplitude electrocardiographic data collection |
US9775536B2 (en) | 2013-09-25 | 2017-10-03 | Bardy Diagnostics, Inc. | Method for constructing a stress-pliant physiological electrode assembly |
US9408545B2 (en) | 2013-09-25 | 2016-08-09 | Bardy Diagnostics, Inc. | Method for efficiently encoding and compressing ECG data optimized for use in an ambulatory ECG monitor |
US10736529B2 (en) | 2013-09-25 | 2020-08-11 | Bardy Diagnostics, Inc. | Subcutaneous insertable electrocardiography monitor |
US9717433B2 (en) | 2013-09-25 | 2017-08-01 | Bardy Diagnostics, Inc. | Ambulatory electrocardiography monitoring patch optimized for capturing low amplitude cardiac action potential propagation |
US9504423B1 (en) | 2015-10-05 | 2016-11-29 | Bardy Diagnostics, Inc. | Method for addressing medical conditions through a wearable health monitor with the aid of a digital computer |
US9433367B2 (en) | 2013-09-25 | 2016-09-06 | Bardy Diagnostics, Inc. | Remote interfacing of extended wear electrocardiography and physiological sensor monitor |
US9619660B1 (en) | 2013-09-25 | 2017-04-11 | Bardy Diagnostics, Inc. | Computer-implemented system for secure physiological data collection and processing |
US10251576B2 (en) | 2013-09-25 | 2019-04-09 | Bardy Diagnostics, Inc. | System and method for ECG data classification for use in facilitating diagnosis of cardiac rhythm disorders with the aid of a digital computer |
US11213237B2 (en) | 2013-09-25 | 2022-01-04 | Bardy Diagnostics, Inc. | System and method for secure cloud-based physiological data processing and delivery |
WO2015048194A1 (en) | 2013-09-25 | 2015-04-02 | Bardy Diagnostics, Inc. | Self-contained personal air flow sensing monitor |
US9737224B2 (en) | 2013-09-25 | 2017-08-22 | Bardy Diagnostics, Inc. | Event alerting through actigraphy embedded within electrocardiographic data |
US10219698B2 (en) * | 2013-10-29 | 2019-03-05 | General Electric Company | Acquisition sample clock synchronization leveraging a global clocking mechanism in a distributed physiological sensing system |
US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
USD744659S1 (en) | 2013-11-07 | 2015-12-01 | Bardy Diagnostics, Inc. | Extended wear electrode patch |
USD801528S1 (en) | 2013-11-07 | 2017-10-31 | Bardy Diagnostics, Inc. | Electrocardiography monitor |
USD892340S1 (en) | 2013-11-07 | 2020-08-04 | Bardy Diagnostics, Inc. | Extended wear electrode patch |
USD717955S1 (en) | 2013-11-07 | 2014-11-18 | Bardy Diagnostics, Inc. | Electrocardiography monitor |
USD831833S1 (en) | 2013-11-07 | 2018-10-23 | Bardy Diagnostics, Inc. | Extended wear electrode patch |
USD793566S1 (en) | 2015-09-10 | 2017-08-01 | Bardy Diagnostics, Inc. | Extended wear electrode patch |
US10758132B2 (en) | 2013-11-27 | 2020-09-01 | Harinath Garudadri | Ambulatory diagnostic device and method thereof |
US10264995B2 (en) | 2013-12-04 | 2019-04-23 | Obalon Therapeutics, Inc. | Systems and methods for locating and/or characterizing intragastric devices |
JP6354143B2 (ja) * | 2013-12-10 | 2018-07-11 | Tdk株式会社 | 情報提供システム、電子機器、方法及びプログラム |
US10521561B1 (en) * | 2013-12-17 | 2019-12-31 | Etectrx, Inc. | Electronic compliance system and associated methods |
EP3476430B1 (en) | 2014-05-16 | 2020-07-01 | Aleva Neurotherapeutics SA | Device for interacting with neurological tissue |
EP3148431A4 (en) * | 2014-05-16 | 2018-04-04 | Masdar Institute of Science and Technology | Self-powered microsensors for in-situ spatial and temporal measurements and methods of using same in hydraulic fracturing |
US11311718B2 (en) | 2014-05-16 | 2022-04-26 | Aleva Neurotherapeutics Sa | Device for interacting with neurological tissue and methods of making and using the same |
US9474894B2 (en) | 2014-08-27 | 2016-10-25 | Aleva Neurotherapeutics | Deep brain stimulation lead |
US9403011B2 (en) | 2014-08-27 | 2016-08-02 | Aleva Neurotherapeutics | Leadless neurostimulator |
AU2015316581B2 (en) | 2014-09-17 | 2020-06-11 | Mars, Incorporated | Device |
WO2016042301A1 (en) | 2014-09-17 | 2016-03-24 | Mars, Incorporated | Device |
US9895248B2 (en) | 2014-10-09 | 2018-02-20 | Obalon Therapeutics, Inc. | Ultrasonic systems and methods for locating and/or characterizing intragastric devices |
US20160174842A1 (en) * | 2014-12-17 | 2016-06-23 | Elwha Llc | Epidermal electronics systems having radio frequency antennas systems and methods |
TWI762438B (zh) * | 2015-02-11 | 2022-05-01 | 日商大塚製藥股份有限公司 | 用於可攝入事件感測與分析之系統、裝置及方法 |
CN107683107B (zh) * | 2015-06-02 | 2021-06-04 | 基文影像公司 | 用于体内免疫测定的装置、系统和方法 |
US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
EP3342042B1 (en) * | 2015-08-24 | 2022-04-13 | The Regents of The University of California | Low power magnetic field body area network |
USD766447S1 (en) | 2015-09-10 | 2016-09-13 | Bardy Diagnostics, Inc. | Extended wear electrode patch |
JP6742605B2 (ja) | 2015-12-28 | 2020-08-19 | 国立大学法人東北大学 | 電池、及び、電子機器 |
EP3411111A1 (en) | 2016-02-02 | 2018-12-12 | Aleva Neurotherapeutics SA | Treatment of autoimmune diseases with deep brain stimulation |
US11241166B1 (en) | 2016-02-03 | 2022-02-08 | Verily Life Sciences, LLC | Communications between smart contact lens and ingestible smart pill |
JP6667181B2 (ja) * | 2016-03-10 | 2020-03-18 | 国立大学法人東北大学 | 無線通信システム、無線通信方法、及び、無線装置 |
US11488714B2 (en) | 2016-03-23 | 2022-11-01 | HealthPals, Inc. | Machine learning for collaborative medical data metrics |
US10188861B2 (en) * | 2016-03-29 | 2019-01-29 | Warsaw Orthopedic, Inc. | Bioabsorbable or partially-bioabsorbable bone growth stimulator system and method for manufacturing a bioabsorbable or partially-bioabsorbable bone-regeneration stimulator system |
US10350100B2 (en) | 2016-04-12 | 2019-07-16 | Obalon Therapeutics, Inc. | System for detecting an intragastric balloon |
TWI730087B (zh) * | 2016-04-25 | 2021-06-11 | 日商大塚製藥股份有限公司 | 用於攝入投予具有可攝入事件標記器的藥學產物之組成物和裝置 |
US10357171B2 (en) | 2016-07-08 | 2019-07-23 | General Electric Company | Adjustable ECG sensor and related method |
US10588529B2 (en) | 2016-07-08 | 2020-03-17 | General Electric Company | ECG monitoring system and method |
KR20210018961A (ko) * | 2016-07-22 | 2021-02-18 | 프로테우스 디지털 헬스, 인코포레이티드 | 섭취 가능한 이벤트 마커의 전자기 감지 및 검출 |
US11026609B2 (en) * | 2016-08-09 | 2021-06-08 | Verily Life Sciences Llc | Wake-up batteries for invasive biosensors |
IL265827B2 (en) | 2016-10-26 | 2023-03-01 | Proteus Digital Health Inc | Methods for producing capsules with ingestible event markers |
US10677761B2 (en) | 2016-12-01 | 2020-06-09 | Avery Dennison Retail Information Services, Llc | Systems and methods for monitoring blister pack compliance |
US10517488B2 (en) | 2016-12-21 | 2019-12-31 | General Electric Company | Patient monitoring system and leadset having multiple capacitive patient connectors and a single galvanic patient connector |
US10307073B2 (en) | 2016-12-21 | 2019-06-04 | General Electric Company | ECG sensor with capacitive defibrillation protection |
US11547355B2 (en) | 2016-12-21 | 2023-01-10 | General Electric Company | Capacitive leadwire for physiological patient monitoring |
US11615257B2 (en) * | 2017-02-24 | 2023-03-28 | Endotronix, Inc. | Method for communicating with implant devices |
WO2018156930A1 (en) * | 2017-02-24 | 2018-08-30 | Endotronix, Inc. | Wireless sensor reader assembly |
JP7179758B2 (ja) * | 2017-04-25 | 2022-11-29 | 大塚製薬株式会社 | 摂取可能なイベントマーカを有するリシノプリル組成物 |
TWI780183B (zh) * | 2017-07-20 | 2022-10-11 | 日商大塚製藥股份有限公司 | 可吞食的電子醫療裝置 |
WO2019050933A1 (en) * | 2017-09-05 | 2019-03-14 | University Of Florida Research Foundation | TRANSFER OF WIRELESS ENERGY TO BIOMEDICAL IMPLANTS |
US11017892B1 (en) | 2017-09-11 | 2021-05-25 | Massachusetts Mutual Life Insurance Company | System and method for ingestible drug delivery |
US10702692B2 (en) | 2018-03-02 | 2020-07-07 | Aleva Neurotherapeutics | Neurostimulation device |
WO2019178071A1 (en) * | 2018-03-13 | 2019-09-19 | Progenity, Inc. | Ingestible device with relatively large payload volume |
US10357174B1 (en) | 2018-03-29 | 2019-07-23 | General Electric Company | Adjustable leadwire device for patient physiological monitoring and methods for making the same |
US11278243B2 (en) | 2018-05-16 | 2022-03-22 | General Electric Company | Repositionable surface electrodes |
US11027140B2 (en) * | 2018-06-15 | 2021-06-08 | Wisconsin Alumni Research Foundation | Self-powered, auto-responsive implanted vagal nerve stimulator for weight control |
US20220038032A1 (en) | 2018-09-18 | 2022-02-03 | Northwestern University | Liquid flow induced power generation using nanoscale metal layers |
US11250939B2 (en) | 2019-01-15 | 2022-02-15 | International Business Machines Corporation | Managing personalized substance administration |
US10998091B2 (en) * | 2019-02-07 | 2021-05-04 | Sandeep Patil | Systems for monitoring compliance with a patch dosage regimen and methods of using the same |
US11019567B2 (en) | 2019-02-26 | 2021-05-25 | Chadra Laboratories Llc | Multi-interface transponder device-altering power modes |
FR3093419B1 (fr) * | 2019-03-08 | 2021-06-18 | Univ Grenoble Alpes | Composition et procédé associé de mesure de l’observance thérapeutique |
US11096579B2 (en) | 2019-07-03 | 2021-08-24 | Bardy Diagnostics, Inc. | System and method for remote ECG data streaming in real-time |
US11696681B2 (en) | 2019-07-03 | 2023-07-11 | Bardy Diagnostics Inc. | Configurable hardware platform for physiological monitoring of a living body |
US11116451B2 (en) | 2019-07-03 | 2021-09-14 | Bardy Diagnostics, Inc. | Subcutaneous P-wave centric insertable cardiac monitor with energy harvesting capabilities |
JP2023506713A (ja) * | 2019-12-16 | 2023-02-20 | ニューロスティム テクノロジーズ エルエルシー | 昇圧電荷送達を用いた非侵襲性神経アクティベータ |
US11135431B2 (en) | 2020-01-31 | 2021-10-05 | Advanced Neuromodulation Systems, Inc. | Implantable pulse generator with multiple stimulation engines |
US20210252291A1 (en) * | 2020-02-13 | 2021-08-19 | Advanced Neuromodulation Systems, Inc. | Neuromodulation therapy with a multiple stimulation engine system |
JP2023516370A (ja) * | 2020-03-02 | 2023-04-19 | クラフト ヘルス プライベート リミテッド | 持続的薬物放出のための経口剤形 |
US11369789B2 (en) | 2021-04-05 | 2022-06-28 | Ishaan Jain | Transdermal drug delivery system |
WO2023214260A1 (en) * | 2022-05-03 | 2023-11-09 | Fondazione Istituto Italiano Di Tecnologia | Degradable device for the passive and monitored release of a substance |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5318557A (en) * | 1992-07-13 | 1994-06-07 | Elan Medical Technologies Limited | Medication administering device |
US5792048A (en) * | 1996-09-03 | 1998-08-11 | Schaefer; Guenter | Indentification pill with integrated microchip: smartpill, smartpill with integrated microchip and microprocessor for medical analyses and a smartpill, smartbox, smartplague, smartbadge or smartplate for luggage control on commercial airliners |
US5925030A (en) * | 1994-08-15 | 1999-07-20 | Elan Corporation, Plc | Orally administrable delivery device |
Family Cites Families (2116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US476925A (en) | 1892-06-14 | jeffebs | ||
US500654A (en) | 1893-07-04 | haberthur | ||
US1548459A (en) | 1923-12-14 | 1925-08-04 | Hammer Charles | Metal cap |
US2587158A (en) | 1948-02-27 | 1952-02-26 | Rca Corp | Metal detector |
US2973555A (en) | 1955-09-09 | 1961-03-07 | Agustin Mesa | Rotary press for fabrication of buttons and plastic articles |
NL106749C (zh) | 1956-02-08 | |||
US3069322A (en) | 1958-05-28 | 1962-12-18 | Bergstrom Sune | Pge and pgf |
US3048526A (en) | 1958-08-04 | 1962-08-07 | Wander Company | Medicinal tablet |
US3096248A (en) | 1959-04-06 | 1963-07-02 | Rexall Drug & Chemical Company | Method of making an encapsulated tablet |
US3079824A (en) | 1960-08-09 | 1963-03-05 | Houdaille Industries Inc | Punching device having a spring biased stripper |
US3176399A (en) | 1962-09-20 | 1965-04-06 | Anthony J Marino | Tool punch with spring actuated impact means |
US3799802A (en) | 1966-06-28 | 1974-03-26 | F Schneble | Plated through hole printed circuit boards |
US3852468A (en) | 1967-02-27 | 1974-12-03 | Ici Ltd | Alkanolamine derivatives as {62 -adrenergic blocking agents |
US4089900A (en) | 1967-09-13 | 1978-05-16 | Pfizer Inc. | Antimicrobial agents |
US3928356A (en) | 1967-10-06 | 1975-12-23 | Fujisawa Pharmaceutical Co | 10-{8 4-({107 -Hydroxy alkyl)-1-piperazimyl{9 -dibenzo (h,f) oxofins and thiepins and acetyl esters thereof |
US3726978A (en) | 1967-11-02 | 1973-04-10 | Sandoz Ag | Tetrahydropyridazines and pyridazinones as anti-inflammatory agents |
US3607788A (en) | 1967-11-20 | 1971-09-21 | Robert J Adolph | Liquid electrode material |
US3832470A (en) | 1968-01-29 | 1974-08-27 | H Russek | Treatment of angina pectoris with a long-acting vasodilating agent and a beta adrenergic receptor blocking agent |
US3668210A (en) | 1968-02-07 | 1972-06-06 | Yoshitomi Pharmaceutical | 3-chloro dihydrodibenzazepine derivatives |
US3789123A (en) | 1968-03-27 | 1974-01-29 | Ciba Geigy Corp | Tertiary aminoacids as anti-inflammatory agents |
US3993763A (en) | 1969-03-18 | 1976-11-23 | Ciba-Geigy Corporation | Tertiary aminoacids as anti-inflammatory agents |
US3898210A (en) | 1968-08-21 | 1975-08-05 | Squibb & Sons Inc | 4-Azatricyclo {8 4.3.1.1{hu 3,8{b {9 undecane and related compounds |
US3951950A (en) | 1968-08-21 | 1976-04-20 | E. R. Squibb & Sons, Inc. | 4-Azatricyclo[4.3.1.13,8 ]undecane and related compounds |
US3589943A (en) | 1968-08-29 | 1971-06-29 | Gen Electric | Electrochemical battery |
US3642008A (en) | 1968-09-25 | 1972-02-15 | Medical Plastics Inc | Ground electrode and test circuit |
US3538104A (en) | 1969-02-28 | 1970-11-03 | Geigy Chem Corp | Pyridyl-2-imidazolones |
US3679480A (en) * | 1969-05-08 | 1972-07-25 | Dow Chemical Co | Electrical cell assembly |
US3624126A (en) | 1969-09-02 | 1971-11-30 | Squibb & Sons Inc | {66 {11 , {60 -adamantane acetic acid |
BE757385A (fr) | 1969-10-13 | 1971-04-13 | American Cyanamid Co | Derives de chloropregnane acetonides utilisables comme substances contraceptives |
US3759921A (en) | 1969-10-16 | 1973-09-18 | Lilly Co Eli | Method of suppressing immuneresponse with 1 substituted-3-(2 pyrimidyl)ureas |
US3682160A (en) * | 1969-10-16 | 1972-08-08 | Matsushita Electric Ind Co Ltd | Physiological signal transmitter for use inside the body |
US4000275A (en) | 1969-11-24 | 1976-12-28 | Eli Lilly And Company | Immunosuppressants |
US3719183A (en) * | 1970-03-05 | 1973-03-06 | H Schwartz | Method for detecting blockage or insufficiency of pancreatic exocrine function |
US3694471A (en) | 1970-06-08 | 1972-09-26 | Warner Lambert Pharmaceutical | 17-valerate ester of 6{60 ,9{60 -difluorohydrocortisone, its compositions and use as an anti-inflammatory agent |
US3691214A (en) | 1970-06-08 | 1972-09-12 | Warner Lambert Pharmaceutical | 17-valerate ester of 6alpha,9alpha-difluoroprednisolone,its compositions and use as an anti-inflammatory agent |
US3624216A (en) | 1970-06-25 | 1971-11-30 | Abbott Lab | 8-substituted theophyllines as anti-inflammatory agents |
US3934018A (en) | 1970-09-03 | 1976-01-20 | Abbott Laboratories | 4,6-Dihydro-1,3-dimethyl-8-phenylpyrazolo[4,3-e] [1,4]diazepin-5-(1H)-one and derivatives as anti-inflammatory agents |
US3936393A (en) | 1970-09-22 | 1976-02-03 | The United States Of America As Represented By The Secretary Of Agriculture | Antimicrobial agents and use thereof |
US3865748A (en) | 1970-09-22 | 1975-02-11 | Us Agriculture | Cinnamyl phenol antimicrobial agents |
US3670079A (en) | 1970-10-06 | 1972-06-13 | Merck & Co Inc | Anabolic agents |
US3783160A (en) | 1970-10-28 | 1974-01-01 | Gates Rubber Co | Diethyl allyl phosphonate as an anti-microbial agent |
US3764676A (en) | 1970-10-28 | 1973-10-09 | Gates Rubber Co | Diethyl cyanomethyl phosphonate as an antimicrobial agent |
US3917476A (en) | 1970-10-28 | 1975-11-04 | Gates Rubber Co | Diethyl alpha phosphonate as an (antimicrobial agent) algaecide |
US3980652A (en) | 1970-11-11 | 1976-09-14 | A. Christiaens Societe Anonyme | 2-(4-Methyl-piperazino)-3 or 5 cyano pyridine |
GB1368948A (en) | 1970-11-11 | 1974-10-02 | Manuf Prod Pharma | Pyridine derivatives |
US3998954A (en) | 1971-02-05 | 1976-12-21 | Pfizer Inc. | 1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides used as anti-inflammatory agents |
US4148796A (en) | 1971-03-15 | 1979-04-10 | Sumitomo Chemical Company, Limited | γ-Piperidinobutyrophenones |
US3857955A (en) | 1971-03-29 | 1974-12-31 | Lilly Co Eli | Anti-inflammatory agents |
US3867383A (en) | 1971-03-29 | 1975-02-18 | Ciba Geigy Corp | Monoanthranilatoanilino-s-triazines |
US3886157A (en) | 1971-03-29 | 1975-05-27 | Ciba Geigy Corp | 5,6,8,8B,9-Pentaazanaphth{8 3,2,1-d,e{9 anthracene derivatives |
US3764677A (en) | 1971-06-25 | 1973-10-09 | Gates Rubber Co | Diethyl betaaminoethylphosphonate as an antimicrobial agent |
US3984405A (en) | 1971-06-28 | 1976-10-05 | E. R. Squibb & Sons, Inc. | Anti-inflammatory agents |
JPS4834870A (zh) | 1971-09-10 | 1973-05-22 | ||
US3821401A (en) | 1971-09-13 | 1974-06-28 | Lilly Co Eli | Other publications |
US4029661A (en) | 1971-10-04 | 1977-06-14 | Pcr, Inc. | Process for producing 5-fluorouracil and derivatives thereof in acid and/or alcohol solvents |
US4001421A (en) | 1971-10-27 | 1977-01-04 | Syntex (U.S.A.) Inc. | Thiazole cardiovascular agents |
US3982010A (en) | 1971-10-27 | 1976-09-21 | Syntex (U.S.A.) Inc. | Thiazole cardiovascular agents |
US3897441A (en) | 1971-10-27 | 1975-07-29 | Syntex Inc | Certain thiazole-carboxamides and acylamino-thiazoles |
US3789121A (en) | 1971-11-26 | 1974-01-29 | Warner Lambert Co | 17{60 ,21-orthobutyrates of 6{60 , 9{60 -difluoro-hydrocortisone and 6{60 , 9{60 -difluoroprednisolone, compositions containing same and the use thereof as anti-inflammatory agents |
US4180583A (en) | 1972-01-28 | 1979-12-25 | Richardson-Merrell Inc. | Olefinic 4-substituted piperidino derivatives as therapeutics |
US3965257A (en) | 1972-01-28 | 1976-06-22 | Richardson-Merrell Inc. | Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions |
US3837339A (en) | 1972-02-03 | 1974-09-24 | Whittaker Corp | Blood glucose level monitoring-alarm system and method therefor |
BE794589A (fr) | 1972-02-08 | 1973-05-16 | Cerm Cent Europ Rech Mauvernay | Nouveaux derives du 1,1-diphenyl-ethylene, leur procede de preparation et leurs applications |
US3821377A (en) | 1972-02-22 | 1974-06-28 | Squibb & Sons Inc | Anti-inflammatory agents |
US4044139A (en) | 1974-02-08 | 1977-08-23 | Uniroyal, Inc. | Bis(diphenylaminomethane) antimicrobial agents |
US3954868A (en) | 1972-03-02 | 1976-05-04 | Uniroyal, Inc. | Bis(diphenylaminomethane) antimicrobial agents |
US3933834A (en) | 1972-03-06 | 1976-01-20 | Bayer Aktiengesellschaft | Unsymmetrical esters of N-substituted 1,4-dihydropyridine 3,5-dicarboxylic acid |
DE2210672C3 (de) | 1972-03-06 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
US3867548A (en) | 1972-05-25 | 1975-02-18 | Us Agriculture | Dihydrocinnamyl phenols useful as antimicrobial agents |
US3915889A (en) | 1972-05-25 | 1975-10-28 | Us Agriculture | Dihydrocinnamyl phenol antimicrobial agents |
DE2228363A1 (de) | 1972-06-10 | 1974-01-03 | Bayer Ag | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US3959296A (en) | 1972-06-10 | 1976-05-25 | Bayer Aktiengesellschaft | 1,4-Dihydropyridines |
US3968117A (en) | 1972-06-10 | 1976-07-06 | Bayer Aktiengesellschaft | 1,4-Dihydropyridines |
US3828766A (en) | 1972-08-14 | 1974-08-13 | Jet Medical Prod Inc | Disposable medical electrode |
US3989050A (en) | 1972-09-19 | 1976-11-02 | Gilbert Buchalter | Process for utilizing certain gel compositions for electrical stimulation |
GB1399539A (en) | 1972-11-03 | 1975-07-02 | Science Union & Cie | Tricyclic ureas processes for preparing them and pharma ceutical compositions containing them |
US4117012A (en) | 1972-12-06 | 1978-09-26 | Pfizer Inc. | 2-aminomethyleneindanone analgesic agents |
US4164514A (en) | 1972-12-06 | 1979-08-14 | Pfizer Inc. | 2-Aminomethyleneindanone analgesic agents |
US4022836A (en) | 1972-12-06 | 1977-05-10 | Pfizer Inc. | 2-Aminomethyleneindanone analgesic agents |
DE2303761A1 (de) | 1973-01-26 | 1974-08-01 | Henkel & Cie Gmbh | Neue n,n'-disubstituierte thioharnstoffe, deren herstellung sowie verwendung als antimikrobielle substanzen |
GB1391862A (en) | 1973-04-04 | 1975-04-23 | Yeda Res & Dev | Benzodiazepines |
US3873715A (en) | 1973-04-06 | 1975-03-25 | Univ Miami | Therapeutic agent for improving cardiovascular function |
US3849041A (en) | 1973-04-30 | 1974-11-19 | Minnesota Mining & Mfg | Apparatus for manufacturing environmental seed cells |
US3930005A (en) | 1973-06-15 | 1975-12-30 | Squibb & Sons Inc | Antiinflammatory agents and their use |
US4002775A (en) | 1973-07-09 | 1977-01-11 | Kabara Jon J | Fatty acids and derivatives of antimicrobial agents |
US3856962A (en) | 1973-07-10 | 1974-12-24 | R Alphin | Anti-inflammatory agents |
US4190587A (en) | 1973-08-06 | 1980-02-26 | Hoffmann-La Roche Inc. | 4-(3-Oxo-4-trifluoromethyl-1-octenyl)-2-oxo-2H-cyclopenta[b]furans |
US3944064A (en) * | 1973-10-26 | 1976-03-16 | Alza Corporation | Self-monitored device for releasing agent at functional rate |
US3968125A (en) | 1973-11-05 | 1976-07-06 | Eli Lilly And Company | Dihydroxyhexahydrodibenzo[b,d]pyrans |
US4011321A (en) | 1973-12-19 | 1977-03-08 | Smith Kline & French Laboratories Limited | Pharmaceutical compositions and methods of inhibiting β-adrenergic receptors |
US3991212A (en) | 1973-12-26 | 1976-11-09 | Eli Lilly And Company | Anti-inflammatory agents |
US4314081A (en) | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
US4194009A (en) | 1974-01-10 | 1980-03-18 | Eli Lilly And Company | Aryloxyphenylpropylamines for obtaining a psychotropic effect |
US4313896A (en) | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Aryloxyphenylpropylamines |
US4018895A (en) | 1974-01-10 | 1977-04-19 | Eli Lilly And Company | Aryloxyphenylpropylamines in treating depression |
FR2260331B1 (zh) | 1974-02-08 | 1978-01-13 | Mauvernay Centre Europ Rech | |
US3931197A (en) | 1974-02-08 | 1976-01-06 | Richardson-Merrell Inc. | Substituted piperidine derivatives |
US3949082A (en) | 1974-07-24 | 1976-04-06 | Merck & Co., Inc. | Thiadiazoles as anti-inflammatory agents |
US4106348A (en) * | 1974-02-20 | 1978-08-15 | U.S. Philips Corporation | Device for examination by means of ultrasonic vibrations |
US3946022A (en) | 1974-03-04 | 1976-03-23 | Richardson-Merrell Inc. | Piperidine derivatives |
US3893111A (en) * | 1974-03-14 | 1975-07-01 | Albert Albert F | System and method for remote monitoring of animal temperature |
US3897442A (en) | 1974-03-14 | 1975-07-29 | Syntex Inc | Thiazole cardiovascular agents |
US3949081A (en) | 1974-04-08 | 1976-04-06 | Ciba-Geigy Corporation | 4-Carbamoyl-1-benzazepines as antiinflammatory agents |
US3991201A (en) | 1974-06-27 | 1976-11-09 | Janssen Pharmaceutica N.V. | 1-(β-Aryl-β-R-ethyl)imidazoles as antimicrobial agents |
US3975543A (en) | 1974-07-05 | 1976-08-17 | Eli Lilly And Company | Ethyl- and vinylbenzenes as anti-inflammatory agents |
US4164586A (en) | 1974-07-19 | 1979-08-14 | Hoffmann-La Roche Inc. | Therapeutic agent for improving cardiovascular function |
US4083968A (en) | 1974-07-19 | 1978-04-11 | Hoffmann-La Roche | Therapeutic agent for improving cardiovascular function |
US4076834A (en) | 1974-07-19 | 1978-02-28 | Hoffmann-La Roche Inc. | Therapeutic agents for improving cardiovascular function |
US4058620A (en) | 1974-07-19 | 1977-11-15 | Hoffmann-La Roche Inc. | Therapeutic agents for improving cardiovascular function |
US3967202A (en) | 1974-07-25 | 1976-06-29 | Northern Illinois Gas Company | Data transmission system including an RF transponder for generating a broad spectrum of intelligence bearing sidebands |
US3940407A (en) | 1974-09-16 | 1976-02-24 | Syntex (U.S.A.) Inc. | β-Adrenergic blocking agents in the 1,2,3-thiadiazole series |
US4077397A (en) | 1974-10-07 | 1978-03-07 | Baxter Travenol Laboratories, Inc. | Diagnostic electrode assembly |
US4090752A (en) | 1974-10-07 | 1978-05-23 | Baxter Travenol Laboratories, Inc. | Diagnostic electrode assembly |
ZA755785B (en) | 1974-10-07 | 1976-08-25 | Baxter Laboratories Inc | Diagnostic electrode assembly |
DE2449030A1 (de) | 1974-10-11 | 1976-05-20 | Schering Ag | Neue pyridin-derivate |
US4000282A (en) | 1974-12-16 | 1976-12-28 | Merck & Co., Inc. | 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines |
US4062750A (en) * | 1974-12-18 | 1977-12-13 | James Francis Butler | Thin film electrochemical electrode and cell |
US4048058A (en) | 1975-08-13 | 1977-09-13 | Standard Oil Company (Indiana) | Methods to be used in reforming processes employing multi-metallic catalysts |
US4139589A (en) | 1975-02-26 | 1979-02-13 | Monique Beringer | Process for the manufacture of a multi-zone tablet and tablet manufactured by this process |
US3947475A (en) | 1975-04-28 | 1976-03-30 | Stauffer Chemical Company | 5-Furoyl-2,2,4-trimethyl-1,4-dihydro-1H-1,5-benzodiazepine as an anti-inflammatory agent |
US3978227A (en) | 1975-04-28 | 1976-08-31 | Stauffer Chemical Company | 5-furoyl-2,2,4-trimethyl-1,4-dihydro-1h-1,5-benzodiazepine as an anti-inflammatory agent |
US3998970A (en) | 1975-04-28 | 1976-12-21 | Stauffer Chemical Company | N,N-dimethyl-N'-phenylthiocarbamyl formamidine and its use as an anti-inflammatory agent |
US3968224A (en) | 1975-04-28 | 1976-07-06 | Stauffer Chemical Company | 3-(4'-Chlorophenyl)-5-methyl-4,5-dihydro-1,2,4-oxadiazole, its use as an anti-inflammatory agent |
US4027031A (en) | 1975-04-28 | 1977-05-31 | Stauffer Chemical Company | 2-Cyclopropanecarboxamido-S-halothiazole as anti-inflammatory agents |
US3959368A (en) | 1975-04-28 | 1976-05-25 | Stauffer Chemical Company | N,N-dimethyl-N'-phenylthiocarbamyl formamidine and its use as an anti-inflammatory agent |
US3966944A (en) | 1975-05-19 | 1976-06-29 | Abbott Laboratories | 10 (N-methyl-4-piperidylidene)-10H[1]-benzopyrano[3,2-b]-pyridine as an analgesic, anti-inflammatory and agent against type III hypersensitivity disease |
US4024284A (en) | 1975-06-09 | 1977-05-17 | Eli Lilly And Company | Ethyl- and vinylbenzenes as anti-inflammatory agents |
GB1495778A (en) | 1975-06-18 | 1977-12-21 | Wyeth John & Brother Ltd | Hexahydroazepines |
US4055655A (en) | 1975-07-21 | 1977-10-25 | National Research Laboratories | Complexes of heavy metal ions and polyfunctional organic ligands used as antimicrobial agents |
US3978219A (en) | 1975-07-25 | 1976-08-31 | Stauffer Chemical Company | Nicotinamidoxime as an anti-inflammatory agent |
US3978202A (en) | 1975-07-25 | 1976-08-31 | Stauffer Chemical Company | ο-Chlorobenzamidoxime as an anti-inflammatory agent |
US4011326A (en) | 1975-07-29 | 1977-03-08 | Merck & Co., Inc. | 2-Substituted oxazolo[4,5-b]pyridine anti-inflammatory agents |
AU509371B2 (en) | 1975-08-07 | 1980-05-08 | F. Hoffmann-La Roche Ag | Diazepine Derivatives |
US4025640A (en) | 1975-08-26 | 1977-05-24 | American Hoechst Corporation | Oxothienobenzoxepin-acetic acids, precursors and derivatives thereof |
US4012527A (en) | 1975-09-15 | 1977-03-15 | Stauffer Chemical Company | N,N-Dimethyl-N'-phenylthiocarbamyl formamidine hydrochloride and its use as an anti-inflammatory agent |
US4049805A (en) | 1975-09-30 | 1977-09-20 | Akzona Incorporated | Steroidal erythropoietic agents and therapeutic compositions and methods |
US4004005A (en) | 1975-09-30 | 1977-01-18 | Akzona Incorporated | Steroidal erythropoietic agents and therapeutic compositions and methods |
US3994898A (en) | 1975-10-16 | 1976-11-30 | E. R. Squibb & Sons, Inc. | 1,2,4-Triazolo (4,3-b) pyridazin-3-ones |
FR2330383A1 (fr) | 1975-11-06 | 1977-06-03 | Synthelabo | Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment |
US4082843A (en) | 1975-11-26 | 1978-04-04 | Smith Kline & French Laboratories Limited | 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents |
US4049665A (en) | 1975-12-24 | 1977-09-20 | Colgate-Palmolive Company | Unsymmetrical disulfides as antimicrobial agents |
JPS5946205B2 (ja) | 1976-01-01 | 1984-11-10 | 科研製薬株式会社 | ベンゾイル誘導体を有効成分とする消炎鎮痛剤 |
US4145444A (en) | 1976-01-01 | 1979-03-20 | Kaken Chemical Co., Ltd. | Anti-inflammatory agent of benzoyl derivative |
US4012448A (en) | 1976-01-15 | 1977-03-15 | Stanford Research Institute | Synthesis of adriamycin and 7,9-epiadriamycin |
US4275064A (en) | 1976-02-06 | 1981-06-23 | Interx Research Corporation | Transient pro-drug forms of xanthine derivatives and their use as topical anti-inflammatory agents |
US4130664A (en) | 1976-02-13 | 1978-12-19 | Uniroyal, Inc. | (Bis(diphenylaminomethane) antimicrobial agents |
US4021553A (en) | 1976-03-10 | 1977-05-03 | Eli Lilly And Company | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents |
US4055178A (en) * | 1976-03-10 | 1977-10-25 | Harrigan Roy Major | Drug delivery device for preventing contact of undissolved drug with the stomach lining |
US4018923A (en) | 1976-03-10 | 1977-04-19 | Eli Lilly And Company | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents |
US4017856A (en) | 1976-03-10 | 1977-04-12 | Westinghouse Electric Corporation | Self-calibrating microwave transponder |
US4013672A (en) | 1976-03-15 | 1977-03-22 | E. R. Squibb & Sons, Inc. | 2,5,7,8-Tetrahydro-1,2,4,5,6-pentaazabenzo[6,7]-cyclohepta[1,2,3-cd]-as-indacenes |
US4018779A (en) | 1976-03-25 | 1977-04-19 | E. R. Squibb & Sons, Inc. | Derivatives of 10,11-dihydrobenzo[4,5]cyclohepta[1,2-b]-pyrazolo[4,3-e]pyridine-5(1H)ones |
PL101032B1 (pl) | 1976-04-06 | 1978-11-30 | Sposob otrzymywania 1-nitro-9-dwualkilo-aminoizoalkiloamiroakrydyn lub ich soli | |
US4020072A (en) | 1976-05-04 | 1977-04-26 | E. R. Squibb & Sons, Inc. | 5-Aminomethyl-1H-pyrazolo[3,4-b]pyridines |
US4064258A (en) | 1976-07-19 | 1977-12-20 | Syntex (U.S.A.) Inc. | Thiazole cardiovascular agents |
US4092419A (en) | 1976-06-15 | 1978-05-30 | Merck & Co., Inc. | Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use |
US4143770A (en) | 1976-06-23 | 1979-03-13 | Hoffmann-La Roche Inc. | Method and apparatus for color recognition and defect detection of objects such as capsules |
IL52448A (en) | 1976-07-06 | 1981-09-13 | Bayer Ag | Antimycotic and sporicidal pharmaceutical compositions comprising imidazol-1-yl-(4-phenoxy-phenyl)-(pyridin-2-yl)phenyl methane |
US4056673A (en) | 1976-07-16 | 1977-11-01 | Hoffmann-La Roche Inc. | Phosphonoacetic acid derivatives of nucleosides |
US4064259A (en) | 1976-07-19 | 1977-12-20 | Syntex (U.S.A.) Inc. | Thiazole cardiovascular agents |
US4064257A (en) | 1976-07-19 | 1977-12-20 | Syntex (U.S.A.) Inc. | Thiazole cardiovascular agents |
DE2635665A1 (de) | 1976-08-07 | 1978-02-09 | Bayer Ag | Antimikrobielle mittel |
DE2644833A1 (de) | 1976-10-05 | 1978-04-20 | Boehringer Sohn Ingelheim | Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung |
US4069341A (en) | 1976-10-18 | 1978-01-17 | The Dow Chemical Company | Oxybis(4,1-phenylene(2-oxo-2,1-ethanediyl)) thiocyanate and its use as an antimicrobial agent |
US4304910A (en) | 1978-05-04 | 1981-12-08 | Kewanee Industries, Inc. | Quarnary ammonium polymeric anti-microbial agent |
US4089977A (en) | 1976-11-24 | 1978-05-16 | Kewanee Industries | Polymeric anti-microbial agent |
US4124707A (en) | 1976-12-22 | 1978-11-07 | Schering Corporation | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor |
US4062858A (en) | 1976-12-22 | 1977-12-13 | E. R. Squibb & Sons, Inc. | Derivatives of 5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-11(1H)-ones and 11(1H)-imines |
US4129125A (en) | 1976-12-27 | 1978-12-12 | Camin Research Corp. | Patient monitoring system |
GB1594214A (en) | 1977-01-21 | 1981-07-30 | Cardio Tech | Body electrodes |
US4082087A (en) | 1977-02-07 | 1978-04-04 | Isis Medical Instruments | Body contact electrode structure for deriving electrical signals due to physiological activity |
JPS53113032A (en) | 1977-03-09 | 1978-10-03 | Mitsubishi Chem Ind Ltd | Immune depresants |
US4246411A (en) | 1977-03-14 | 1981-01-20 | Pcr Incorporated | 5,5-Difluorouracil |
DE2711106A1 (de) | 1977-03-15 | 1978-09-21 | Bayer Ag | Bis-(5,5'-dimethyl-1,3-oxazolidin- 3-yl)methan |
US4252815A (en) | 1977-04-21 | 1981-02-24 | Mead Johnson & Company | Methods of treating cardiovascular diseases with phenyltetrazolyloxy propanolamines |
FR2388799A1 (fr) | 1977-04-28 | 1978-11-24 | Rolland Sa A | Derives de pyridazinone, leur procede de preparation et leur application comme medicaments |
DE2720868A1 (de) | 1977-05-10 | 1978-11-23 | Bayer Ag | Antimikrobielle mittel |
US4128664A (en) | 1977-05-16 | 1978-12-05 | Riker Laboratories, Inc. | Substituted benzamides as anti-inflammatory agents |
US4133819A (en) | 1977-06-17 | 1979-01-09 | Pfizer Inc. | Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents |
US4209520A (en) | 1977-06-17 | 1980-06-24 | Pfizer Inc. | Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents |
US4125612A (en) | 1977-06-20 | 1978-11-14 | Schering Corporation | N-1-(p-Biphenylalkyl)piperazines and their use as anti-inflammatory agents |
US4314943A (en) | 1977-07-13 | 1982-02-09 | Mead Johnson & Company | Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols |
US4147798A (en) | 1977-08-02 | 1979-04-03 | W. R. Grace & Co. | Antineoplastic agent |
US4147872A (en) | 1977-09-13 | 1979-04-03 | Pfizer Inc. | 3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives thereof as analgesic agents and intermediates therefor |
US4306097A (en) | 1977-09-13 | 1981-12-15 | Pfizer Inc. | 3-[2-Hydroxy-4-(substituted)phenyl]-cycloalkanol analgesic agents |
US4123550A (en) | 1977-10-31 | 1978-10-31 | Syntex (U.S.A.) Inc. | Bicyclo[3.1.0]hexylethylaminocarbonyl-substituted heteroaryl cardiovascular agents |
US4151297A (en) | 1977-10-31 | 1979-04-24 | Syntex (U.S.A.) Inc. | Bicyclo [3.1.0] hexyl-substituted ethylamino carbonyl phenoxy cardiovascular agents |
US4145443A (en) | 1977-10-31 | 1979-03-20 | Syntex (U.S.A.) Inc. | Bicyclo 3.1.0!hexylethylaminocarbonyl-substituted naphthyloxy cardiovascular agents |
US4143054A (en) | 1977-11-04 | 1979-03-06 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane- and 7-oxabicycloheptene compounds |
US4220594A (en) | 1977-11-04 | 1980-09-02 | E. R. Squibb & Sons, Inc. | Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol |
US4201778A (en) | 1977-11-08 | 1980-05-06 | Schering Corporation | 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates |
JPS5475284A (en) | 1977-11-29 | 1979-06-15 | Asahi Chemical Ind | Threeeterminal magnetic reluctance effect element |
JPS5483301A (en) * | 1977-12-16 | 1979-07-03 | Fujitsu Ltd | Units of erecting equipment for communiacation device |
DE2757680A1 (de) | 1977-12-23 | 1979-06-28 | Troponwerke Gmbh & Co Kg | Neue 2-oxo-1-pyrrolidinessigsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
FR2415099A1 (fr) | 1978-01-20 | 1979-08-17 | Ile De France | Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes |
US4329289A (en) | 1978-02-08 | 1982-05-11 | Hoffmann-La Roche Inc. | Adrenergic blocking agents |
US4247710A (en) | 1978-02-08 | 1981-01-27 | Hoffmann-La Roche Inc. | Intermediate in the production of adrenergic blocking agents |
JPS54119499A (en) | 1978-03-09 | 1979-09-17 | Shionogi & Co Ltd | Triazolobenzodiazepin derivative |
US4181720A (en) | 1978-04-05 | 1980-01-01 | Syntex (U.S.A.) Inc. | Corticosteroid antiinflammatory agents |
GB1573599A (en) | 1978-05-24 | 1980-08-28 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
US4251798A (en) * | 1978-05-31 | 1981-02-17 | Symbol Technologies | Portable laser scanning arrangement for and method of evaluating and validating bar code symbols |
US4177280A (en) | 1978-07-03 | 1979-12-04 | Syntex (U.S.A.) Inc. | Bicyclo[3.1.0]hexyl-substituted carbonylaminophenoxy cardiovascular agents |
US4214089A (en) | 1978-07-18 | 1980-07-22 | American Home Products Corporation | Thiazolo[3,2-a]benzimidazoles, imidazo [2,1-b]thiazoles, and related compounds as antineoplastic agents, and enhancers of the immune response |
ATE165T1 (de) | 1978-07-28 | 1981-09-15 | Synthelabo | Fluoren- und fluoranthenderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. |
US4267328A (en) | 1978-08-01 | 1981-05-12 | Synthelabo | 1-Phenylpiperazines |
JPS5538325A (en) | 1978-09-11 | 1980-03-17 | Sankyo Co Ltd | 4-anilinoquinazoline derivative and its preparation |
US4239046A (en) | 1978-09-21 | 1980-12-16 | Ong Lincoln T | Medical electrode |
US4342769A (en) | 1978-10-02 | 1982-08-03 | Schering Corporation | 2-[(Methylsulfinyl)acetyl]-3-heterocyclicindoles and derivatives thereof as immunosuppressants |
EP0011173B1 (en) | 1978-11-01 | 1983-05-11 | Sanraku-Ocean Co., Ltd. | Process for producing antibiotic beta-lactam compounds |
US5066493A (en) | 1978-11-03 | 1991-11-19 | American Home Products Corporation | Rapamycin in treatment of tumors |
US4173650A (en) | 1978-11-03 | 1979-11-06 | American Cyanamid Company | Cis-2-benzoyl-3-hydroxy-2-alkenonitriles as anti-inflammatory agents |
US4355034A (en) | 1979-02-07 | 1982-10-19 | Merck & Co., Inc. | Ethenyl derivatives of mercaptoalkylpyridines as anti-inflammatory agents |
DK53780A (da) | 1979-02-16 | 1980-08-17 | Sandoz Ag | Fremgangsmaade til fremstilling af cephalosporinderivater |
US4173634A (en) | 1979-02-23 | 1979-11-06 | E. R. Squibb & Sons, Inc. | Basically-substituted tricyclic pyrazoles useful as antiinflammatory agents |
US4234593A (en) | 1979-03-20 | 1980-11-18 | Stauffer Chemical Company | 3-(N-Alkylcarbamyl)-5-(carboalkoxy)-1,3,4-oxadiazole-2-thiones and their use as anti-inflammatory agents |
US4226887A (en) | 1979-04-16 | 1980-10-07 | Eli Lilly And Company | Anti-inflammatory agents |
US4345588A (en) * | 1979-04-23 | 1982-08-24 | Northwestern University | Method of delivering a therapeutic agent to a target capillary bed |
FR2455039A1 (fr) | 1979-04-26 | 1980-11-21 | Synthelabo | Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique |
US4244955A (en) | 1979-04-30 | 1981-01-13 | Richardson-Merrell Inc. | 2,4a-Ethanobenz[g]isoquinolin-5(1H)-ones and their use as anti-fertility and analgesic agents |
US4260634A (en) | 1979-06-18 | 1981-04-07 | International Minerals & Chemical Corp. | Antimicrobial agents |
US4308283A (en) | 1979-06-18 | 1981-12-29 | International Minerals & Chemical Corp. | Antimicrobial agents |
US4269189A (en) | 1979-07-09 | 1981-05-26 | Consolidated Medical Equipment Inc. | Skin conducting electrode assembly |
DE2928477C3 (de) * | 1979-07-14 | 1982-04-15 | Battelle-Institut E.V., 6000 Frankfurt | Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes |
DE2931778A1 (de) | 1979-08-04 | 1981-02-19 | Bayer Ag | Antimikrobielle mittel |
US4283394A (en) | 1979-08-06 | 1981-08-11 | Research Corporation | Cytotoxic nucleoside-corticosteroid phosphodiesters |
US4450159A (en) | 1979-08-08 | 1984-05-22 | The Upjohn Company | Carbamic acid derivatives as selective immunosuppresive agents |
CA1151651A (en) | 1979-08-08 | 1983-08-09 | Takao Kiyohara | Antitumor and immunosuppressive 4-carbamoyl imidazolium-5-olate derivatives, pharmaceutical composition and production thereof |
JPS5645460A (en) | 1979-09-20 | 1981-04-25 | Sumitomo Chem Co Ltd | Novel imidazolyl sulfonate derivative |
US4261328A (en) | 1979-08-10 | 1981-04-14 | Kirk Norbert A | Teakettle with attached boiling vessel |
US4285873A (en) | 1979-09-06 | 1981-08-25 | Hoffmann-La Roche Inc. | Adrenergic blocking agents |
US4278608A (en) | 1979-09-06 | 1981-07-14 | Hoffmann-La Roche Inc. | Adrenergic blocking agents |
US4281189A (en) | 1979-09-06 | 1981-07-28 | Hoffmann-La Roche Inc. | Sulfonamide intermediates for adrenergic blocking agents |
US4304721A (en) | 1979-09-06 | 1981-12-08 | Hoffmann-La Roche Inc. | Adrenergic blocking agents |
US4244963A (en) | 1979-09-27 | 1981-01-13 | Merck & Co., Inc. | 1-[2-(Alkyl and arylsulfonyl)-2-propenyl and propyl] substituted piperidines useful as antimicrobial and antiinflammatory agents |
HU185926B (en) | 1979-09-27 | 1985-04-28 | Agostne Kahan | Process for preparing water soluble derivatives of non-steroid antiinflammatory compositions and pharmaceutical compositins containing such derivatives |
DE2943776A1 (de) | 1979-10-26 | 1981-05-14 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung |
JPS6043064B2 (ja) | 1979-11-28 | 1985-09-26 | ウェルファイド株式会社 | 新規イソオキサゾ−ル誘導体 |
US4252816A (en) | 1979-12-03 | 1981-02-24 | Merck & Co., Inc. | Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents |
MC1357A1 (fr) | 1979-12-07 | 1981-08-10 | Hoffmann La Roche | Derives de 2,3-indoledione |
US4335141A (en) | 1979-12-26 | 1982-06-15 | Merck & Co., Inc. | 2-Substituted-aminopropene-and propanenitrile antimicrobial and anti-inflammatory agents |
US4311709A (en) | 1979-12-26 | 1982-01-19 | Merck & Co., Inc. | Loweralkyl substituted diphenyl polyamine as an antimicrobial agent |
IE810250L (en) | 1980-02-11 | 1981-08-11 | Berlex Lab | N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines. |
JPS56113748A (en) | 1980-02-13 | 1981-09-07 | Kowa Co | Aminoethanol derivative and its preparation |
US4251530A (en) | 1980-02-19 | 1981-02-17 | Merck & Co., Inc. | 2-{[4-(6-Substituted-2-pyrazinyl)-1-piperazinyl]alkyl}-5-substituted-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one analgesic agents |
US4391982A (en) | 1980-03-05 | 1983-07-05 | The University Of Rochester | Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof |
US4294763A (en) | 1980-03-05 | 1981-10-13 | University Of Rochester | Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof |
US4399283A (en) | 1980-03-11 | 1983-08-16 | Warner Lambert Company | Pharmaceutical salts of 4'-(9-acridinylamino)-methanesulfon-m-anisidide |
FR2480283A1 (fr) | 1980-04-10 | 1981-10-16 | Science Union & Cie | Nouveaux derives tricycliques, leurs procedes de preparation et leur utilisation comme medicament |
DE3018865A1 (de) | 1980-05-16 | 1981-11-26 | Bayer Ag, 5090 Leverkusen | Antimikrobielle mittel |
DE3019322A1 (de) | 1980-05-21 | 1981-12-03 | Merck Patent Gmbh, 6100 Darmstadt | Psychopharmakon sowie verwendung von adenosinderivaten |
US4331654A (en) * | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
US4996335A (en) | 1980-07-10 | 1991-02-26 | Nicholas S. Bodor | Soft steroids having anti-inflammatory activity |
US4710495A (en) | 1980-07-10 | 1987-12-01 | Otsuka Pharmaceutical Co., Ltd. | Soft steroids having anti-inflammatory activity |
US4361583A (en) | 1980-08-19 | 1982-11-30 | Synthelabo | Analgesic agent |
US4393210A (en) | 1980-08-28 | 1983-07-12 | Seiyaku Co., Ltd. | 1(2H)-Isoquinolone compounds and acid addition salts thereof |
US4391827A (en) | 1980-09-08 | 1983-07-05 | Pfizer Inc. | 3-(2-Hydroxy-4-(substituted)phenyl)-cycloalkanone and cycloalkanol analgesic agents and intermediates therefor |
JPS5767516A (en) | 1980-09-24 | 1982-04-24 | Microbial Chem Res Found | Novel analgesic agent |
US4578061A (en) * | 1980-10-28 | 1986-03-25 | Lemelson Jerome H | Injection catheter and method |
JPS57106617A (en) | 1980-12-23 | 1982-07-02 | Sankyo Co Ltd | Analgesic and anti-inflammatory agent |
US4568679A (en) | 1980-12-23 | 1986-02-04 | Merck & Co., Inc. | Aralkylaminoethanol heterocyclic compounds |
ZA8231B (en) | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
US4599228A (en) | 1981-01-19 | 1986-07-08 | Vipont Laboratories, Inc. | Antimicrobial agent |
US4520026A (en) | 1981-02-06 | 1985-05-28 | S. A. Labaz N.V. | Indolizine derivatives and use as cardiovascular agents |
DE3104380A1 (de) | 1981-02-07 | 1982-08-19 | Bayer Ag, 5090 Leverkusen | Antimikrobielle mittel |
US4412995A (en) | 1981-02-19 | 1983-11-01 | Sterling Drug Inc. | Pentacyclic phenylpyrazole compounds as anti-inflammatory agents |
US4370484A (en) | 1981-03-12 | 1983-01-25 | The Regents Of The University Of California | Sceptrin an antimicrobial agent from Agelas sceptrum |
US4443451A (en) | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
US4440763A (en) | 1981-03-18 | 1984-04-03 | Block Drug Company, Inc. | Use of 4-aminosalicyclic acid as an anti-inflammatory agent |
JPS57169490A (en) | 1981-04-10 | 1982-10-19 | Kumiai Chem Ind Co Ltd | 2,3-disubstituted-5,6-dihydro-imidazo(2,1-b)thiazole, its salt and their preparation |
US4501755A (en) | 1981-05-01 | 1985-02-26 | Pennwalt Corporation | Isoflavones useful as anti-inflammatory agents |
US4440779A (en) | 1981-06-30 | 1984-04-03 | Merck & Co., Inc. | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents |
US4568762A (en) | 1981-07-01 | 1986-02-04 | Hoffmann-La Roche Inc. | 4-Methyl-2-oxo-cyclopentylidene acetic acid and esters thereof |
US4548938A (en) | 1981-07-15 | 1985-10-22 | Janssen Pharmaceutica N.V. | 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds |
US4434175A (en) | 1981-08-10 | 1984-02-28 | Merck & Co., Inc. | Nonsteroidal compounds as anti-inflammatory and analgesic agents |
US4418697A (en) * | 1981-08-17 | 1983-12-06 | Francine Tama | Electrode attachment method |
US4490540A (en) | 1981-09-14 | 1984-12-25 | Janssen Pharmaceutica N.V. | (2-Aryl-4-phenylthioalkyl-1,3-dioxolan-2-ylmethyl)azole derivatives |
US4410696A (en) | 1981-09-24 | 1983-10-18 | Sumitomo Chemical Company, Limited | Antitumor and immunosuppressive 4-carbamoylimidazolium-5-olate derivatives |
ATE12072T1 (de) | 1981-09-25 | 1985-03-15 | Lacer Sa | 1-azaxanthon zur therapeutischen verwendung, verfahren zu seiner herstellung und pharmazeutische zusammensetzungen. |
US4514415A (en) | 1981-10-28 | 1985-04-30 | Ciba Geigy Corporation | Benzofuran-2(3H)-ones used as anti-inflammatory agents |
US4374139A (en) | 1981-11-09 | 1983-02-15 | Hoffmann-La Roche Inc. | Levorotatory N-substituted acylmorphinans useful as analgesic agents |
US4537981A (en) | 1981-11-09 | 1985-08-27 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane and 7-oxabicycloheptene compounds |
US4567201A (en) | 1981-11-25 | 1986-01-28 | Takeda Chemical Industries, Ltd. | Diphenoxypropane derivatives and compositions of antiasthmatic and antiinflammatory agents thereof |
ATE15762T1 (de) | 1981-12-08 | 1985-10-15 | Smithkline Beckman Corp | Pharmazeutische zusammensetzungen mit gehalt an 7,8-dihydroxy-1-(hydroxy-phenyl)-2,3,4,5tetrahydro-1h-3-benzazepin-derivaten und an einem beta-adrenergischen blocker. |
US4578390A (en) | 1981-12-14 | 1986-03-25 | Merck & Co., Inc. | Hydroxybenzylamino derivatives as anti-inflammatory agents |
US4891370A (en) | 1981-12-14 | 1990-01-02 | Merck & Co., Inc. | Cephalosporin derivatives as anti-inflammatory agents |
US4536503A (en) | 1981-12-14 | 1985-08-20 | Syntex (U.S.A.) Inc. | Naphthoxyalkylamines and related compounds as antiinflammatory agents |
US4432292A (en) | 1982-01-18 | 1984-02-21 | Scott Kenneth G | Floating planter |
US4494950A (en) * | 1982-01-19 | 1985-01-22 | The Johns Hopkins University | Plural module medication delivery system |
US4383994A (en) | 1982-01-19 | 1983-05-17 | Mccully Kilmer S | Homocysteine thiolactone salts and use thereof as anti-neoplastic agents |
DE3204795A1 (de) | 1982-02-11 | 1983-08-18 | Bayer Ag, 5090 Leverkusen | Azolyl-phenoxy-tetrahydrofuran-2-yliden-methane, verfahren zu ihrer herstellung sowie antimikrobielle mittel, die diese stoffe enthalten |
US4512990A (en) | 1982-02-18 | 1985-04-23 | Syntex (U.S.A.), Inc. | Benzthiazine analogs as antiinflammatory agents |
US4439196A (en) * | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4544501A (en) | 1982-04-12 | 1985-10-01 | The Research Foundation Of State University Of New York | Bis(2,2-dimethyl-1-aziridinyl)phosphinic amides for use in the treatment of tumors |
US4435420A (en) | 1982-04-12 | 1984-03-06 | Merrell Dow Pharmaceuticals | Anti-inflammatory agents and antiasthmatic agents |
US4886790A (en) | 1982-04-12 | 1989-12-12 | The Research Foundation Of State University Of New York | Novel bis(2,2-dimethyl-1-aziridinyl) phosphinic amides for use in the treatment of tumors |
US4529727A (en) | 1982-04-21 | 1985-07-16 | Janssen Pharmaceutical, N.V. | Pyrimido[2,1-b][1,3]-thiazines |
JPS58185562A (ja) | 1982-04-22 | 1983-10-29 | Taisho Pharmaceut Co Ltd | 1,4−ジヒドロピリジン誘導体 |
US4418076A (en) | 1982-05-03 | 1983-11-29 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane hydrazone prostaglandin analogs useful in treating thrombolytic diseases |
DE3216895A1 (de) | 1982-05-06 | 1983-11-10 | Henkel KGaA, 4000 Düsseldorf | 2-(3-iod-2-propinyloxy)-ethanol-carbamate, ihre herstellung und ihre verwendung als antimikrobielle substanzen |
US4474806A (en) | 1982-05-10 | 1984-10-02 | Merck & Co., Inc. | Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents |
US4556675A (en) | 1982-05-17 | 1985-12-03 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane and 7-oxabicycloheptene compounds |
US4614825A (en) | 1982-05-17 | 1986-09-30 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane and 7-oxabicycloheptene compounds |
US4416896A (en) | 1982-05-17 | 1983-11-22 | E. R. Squibb & Sons, Inc. | 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease |
US4537904A (en) | 1982-05-17 | 1985-08-27 | E. R. Squibb & Sons, Inc. | Compositions of 7-oxabicycloheptane and 7-oxabicycloheptene compounds and a method for their use in inhibiting bronchoconstriction |
US4495197A (en) | 1982-05-24 | 1985-01-22 | Merck & Co., Inc. | N-Carboxyl-thienamycin esters and analogs thereof as anti-inflammatory agents |
US4493839A (en) | 1982-05-24 | 1985-01-15 | Merck & Co., Inc. | 1-Carbapenem-3-carboxylic esters as anti-inflammatory agents |
US4465687A (en) | 1982-05-24 | 1984-08-14 | Merck & Co., Inc. | Thienamycin derivatives as anti-inflammatory agents |
US4511724A (en) | 1982-06-10 | 1985-04-16 | Merck & Co., Inc. | 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents |
US4427694A (en) | 1982-06-11 | 1984-01-24 | The Vinoxen Company, Inc. | Sesamin as a psychotropic agent |
US4424202A (en) | 1982-06-11 | 1984-01-03 | The Vinoxen Company, Inc. | Azelaaldehydates as psychotropic agents |
US4440781A (en) | 1982-06-11 | 1984-04-03 | The Vinoxen Company, Inc. | Oxyoctadecanoates as psychotropic agents |
US4588530A (en) | 1982-07-30 | 1986-05-13 | Florida Agricultural And Mechanical University | Anti-inflammatory prednisolone steroids |
US4463015A (en) | 1982-08-18 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation |
US4539326A (en) | 1982-08-20 | 1985-09-03 | Takeda Chemical Industries, Ltd. | 5-Oxo-5H-(1)benzopyrano(2,3-b)pyridine derivatives, their production and use as anti-inflammatory agents |
ES8404694A1 (es) | 1982-08-20 | 1984-05-01 | Nativelle Sa Ets | Procedimiento de preparacion de nuevos derivos de amino-14 esteroides |
US4495102A (en) | 1982-09-03 | 1985-01-22 | G. D. Searle & Co. | Aminoalkyl steroids |
US4489098A (en) | 1982-09-28 | 1984-12-18 | The Dow Chemical Company | 2,2,3-Trihalopropionaldehydes as antimicrobial agents |
US4631283A (en) | 1982-09-30 | 1986-12-23 | Ortho Pharmaceutical Corporation | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids |
FR2533928A1 (fr) | 1982-10-05 | 1984-04-06 | Roussel Uclaf | Nouveaux derives dichlores de la serie du 16a-methyl pregnane, leur procede de preparation et leur application comme medicaments |
US4536512A (en) | 1982-10-08 | 1985-08-20 | Merck & Co., Inc. | 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents |
US4533671A (en) | 1982-10-08 | 1985-08-06 | Merck & Co., Inc. | 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic acids and analogs as anti-inflammatory and analgesic agents |
US4456615A (en) | 1982-10-25 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
JPS59112984A (ja) | 1982-12-21 | 1984-06-29 | Shionogi & Co Ltd | 1,4−ベンゾジアゼピン誘導体 |
JPS5997924U (ja) | 1982-12-22 | 1984-07-03 | 宮崎製陶株式会社 | 陶磁製生素地成型品の積重ね矯正装置 |
US4456616A (en) | 1982-12-27 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
US4456617A (en) | 1983-01-12 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
US4466979A (en) | 1983-01-21 | 1984-08-21 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted carbamate prostaglandin analogs useful in treating platelet aggregation and bronchoconstriction |
JPS59139400A (ja) | 1983-01-31 | 1984-08-10 | Shionogi & Co Ltd | 抗アルドステロン活性ステロイド誘導体 |
EP0119774B1 (en) | 1983-03-09 | 1987-06-24 | Beecham Group Plc | Anti-inflammatory pyrazolo pyridines |
US4474803A (en) | 1983-03-14 | 1984-10-02 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted thio prostaglandin analogs useful in treating platelet aggregation and bronchoconstriction |
US4582854A (en) | 1983-03-14 | 1986-04-15 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted oxa prostaglandin analgos useful in the treatment of thrombolytic disease |
JPS59186969A (ja) | 1983-04-08 | 1984-10-23 | Yoshitomi Pharmaceut Ind Ltd | ベンゾフラン−およびベンゾピランカルボキサミド誘導体 |
US4552871A (en) | 1983-04-13 | 1985-11-12 | Ciba Geigy Corporation | Steroids of the 20-spiroxane series, processes for the manufacture thereof, pharmaceutical preparations containing such compounds and the use of the latter |
FR2544718B1 (fr) | 1983-04-21 | 1985-12-20 | Hexachimie | Diniflumate d'ester morpholinoethylique d'acide niflumique, preparation, utilisation en therapeutique comme analgesique et anti-inflammatoire |
EP0123734A1 (en) | 1983-04-29 | 1984-11-07 | Gist-Brocades N.V. | 17-(Isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation |
US4517188A (en) | 1983-05-09 | 1985-05-14 | Mead Johnson & Company | 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols |
US4680298A (en) | 1983-05-31 | 1987-07-14 | Schering Corporation | Tricyclic anti-allergy and use as anti-inflammatory agents |
FR2547587B1 (fr) | 1983-06-14 | 1985-10-25 | Roussel Uclaf | Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation |
DE3324192A1 (de) | 1983-07-05 | 1985-01-17 | Troponwerke Gmbh & Co Kg | Depot-antiphlogistika |
DE3324193A1 (de) | 1983-07-05 | 1985-01-17 | Troponwerke Gmbh & Co Kg | Depot-antiphlogistika |
FR2559484B2 (fr) | 1983-07-06 | 1986-09-26 | Provesan Sa | Nouveau derive 7-(pyrrol-1-yl) de l'acide 1-ethyl-1,4-dihydro-4-oxo-(1,8-naphtyridin)-3-carboxylique, sa preparation et son application en tant que medicament |
US4550186A (en) | 1983-07-11 | 1985-10-29 | Duke University | Binuclear copper (II) carboxylates formed from amine-carboxyboranes |
US4564363A (en) * | 1983-07-13 | 1986-01-14 | Smithkline Beckman Corporation | Delayed action assembly |
US4512986A (en) | 1983-07-26 | 1985-04-23 | Research Triangle Institute | Progrestationally active steroids |
US4541956A (en) | 1983-07-28 | 1985-09-17 | Unique Technologies, Inc. | Tin steroids and their use as antineoplastic agents |
US4634693A (en) | 1983-07-28 | 1987-01-06 | Cardarelli Nathan F | Tin steroids and their uses |
US5656621A (en) | 1983-08-02 | 1997-08-12 | Research Corporation Tech., Inc. | Steroids useful as anti-cancer and anti-obesity agents |
CA1239934A (en) | 1983-08-05 | 1988-08-02 | Lloyl D. Hayward | D-isoidide and nitrates thereof |
JPS6038323A (ja) | 1983-08-10 | 1985-02-27 | Sankyo Co Ltd | 眼科用消炎剤 |
GB8322007D0 (en) | 1983-08-16 | 1983-09-21 | Wellcome Found | Pharmaceutical delivery system |
AU571554B2 (en) | 1983-08-24 | 1988-04-21 | Kotobuki Seiyaku Co. Ltd. | Azulene sulfonates |
CA1252778A (en) | 1983-08-25 | 1989-04-18 | Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee | Steroids |
US4479953A (en) | 1983-08-25 | 1984-10-30 | Merck & Co., Inc. | Pyrazine aldimine compounds as antimicrobial agents |
US4525479A (en) | 1983-08-29 | 1985-06-25 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted thiocarbamate prostaglandin analogs useful as cardiovascular agents |
US4645836A (en) | 1983-09-12 | 1987-02-24 | Ortho Pharmaceutical Corporation | Process for the preparation of 6,7-dihydroxy-4-alkyl-2(1H) quinazolinone-1-propionic acids |
US4474804A (en) | 1983-09-19 | 1984-10-02 | E. R. Squibb & Sons, Inc. | 7-Oxabicyclo substituted prostaglandin phenyl carboxylic acid derivatives useful as cardiovascular agents |
US4656267A (en) | 1983-09-29 | 1987-04-07 | Ortho Pharmaceutical Corporation | Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters |
US4555571A (en) | 1983-09-29 | 1985-11-26 | Ortho Pharmaceutical Corporation | Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters |
US4556739A (en) | 1983-09-29 | 1985-12-03 | Ortho Pharmaceutical Corporation | 3,4-Dialkoxy-2-alkylcarbonyl analino compounds |
US4555570A (en) | 1983-09-29 | 1985-11-26 | Ortho Pharmaceutical Corporation | Substituted 4-alkyl-2-(1H) quinazolinone-1-alkanoic acid derivatives |
US4613600A (en) | 1983-09-30 | 1986-09-23 | Mead Johnson & Company | Antidepressant 1,2,4-triazolone compounds |
US4774256A (en) | 1983-10-03 | 1988-09-27 | E. R. Squibb & Sons, Inc. | Use of enkephalinase inhibitors as analgesic agents |
US4749575A (en) | 1983-10-03 | 1988-06-07 | Bio-Dar Ltd. | Microencapsulated medicament in sweet matrix |
GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
US4778818A (en) | 1983-10-12 | 1988-10-18 | Merck & Co., Inc. | Substituted 2-(heteroaryl-2-propenyl)phenols useful as anti-inflammatory agents |
US4686235A (en) | 1983-10-12 | 1987-08-11 | Merck & Co., Inc. | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents |
US4537903A (en) | 1983-10-12 | 1985-08-27 | Merck & Co., Inc. | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents |
US4522949A (en) | 1983-10-20 | 1985-06-11 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful as cardiovascular agents |
US4492700A (en) | 1983-10-24 | 1985-01-08 | Merck & Co., Inc. | 3-Halo-2-thiopyrazines as antimicrobial agents |
GB8328757D0 (en) | 1983-10-27 | 1983-11-30 | Wellcome Found | Chemical compounds |
US4681879A (en) | 1983-11-07 | 1987-07-21 | Hoechst-Roussel Pharmaceuticals Inc. | 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents |
US4667039A (en) | 1983-11-07 | 1987-05-19 | Hoechst-Roussel Pharmaceuticals Inc. | 11-substituted 5H,11H-pyrrolo(2,1-C) (1,4)benzoxazepines as antipsychotic and analgesic agents |
US4608374A (en) | 1983-11-07 | 1986-08-26 | Hoechst-Roussel Pharmaceuticals Inc. | 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents |
US4560557A (en) | 1983-11-10 | 1985-12-24 | University Patents, Inc. | Silicon and sulfur steroids as irreversible inhibitors of hormone biosynthesis |
US4524151A (en) | 1983-11-14 | 1985-06-18 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane thio ethers useful as cardiovascular agents |
US4563476A (en) | 1983-11-21 | 1986-01-07 | Merck & Co., Inc. | Substituted 5-hydroxy-2,3-dihydrobenzofurans and analogs thereof useful as anti-inflammatory agents |
US4559950A (en) | 1983-11-25 | 1985-12-24 | Graphic Controls Corporation | Disposable biomedical and diagnostic electrode |
US4632923A (en) | 1984-08-15 | 1986-12-30 | Schering Corporation | Substituted hetero spiro pyridine derivatives as anti-allergy and anti-inflammatory agents |
US4652564A (en) | 1983-12-14 | 1987-03-24 | Schering Corporation | Substituted spiro pyridine derivatives as anti-allergy and antiinflammatory agents |
US4532327A (en) | 1983-12-28 | 1985-07-30 | The United States Of America As Represented By The Secretary Of Agriculture | Sesbanimide and the use thereof in treating leukemic tumors |
DE3402392A1 (de) | 1984-01-25 | 1985-08-01 | Sandoz-Patent-GmbH, 7850 Lörrach | Neue ergolinderivate, deren herstellung und deren verwendung |
US4526901A (en) | 1984-01-26 | 1985-07-02 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted oxamide prostaglandin analogs and their use in treating thrombolytic disease |
US4533673A (en) | 1984-01-26 | 1985-08-06 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted enaminone prostaglandin analogs and their use in treatment of thrombolytic disease |
US4526900A (en) | 1984-01-26 | 1985-07-02 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease |
US4721712A (en) | 1984-06-12 | 1988-01-26 | Pfizer Inc. | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents |
IN163263B (zh) | 1984-02-07 | 1988-08-27 | Pfizer | |
US4593029A (en) | 1984-02-15 | 1986-06-03 | Syntex (U.S.A.) Inc. | Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones |
US4558067A (en) | 1984-03-01 | 1985-12-10 | Merck & Co., Inc. | Phenylthiomethyl-6-hydroxy-2,3-dihydrobenzo-pyran and analogs thereof useful as anti-inflammatory agents |
US5334601A (en) | 1984-03-14 | 1994-08-02 | Bodor Nicholas S | Soft β-adrenergic blocking agents |
US4829086A (en) | 1984-03-14 | 1989-05-09 | Bodor Nicholas S | Soft β-adrenergic blocking agents |
US5135926A (en) | 1984-03-14 | 1992-08-04 | Bodor Nicholas S | Soft β-adrenergic blocking agents |
US4536513A (en) | 1984-03-14 | 1985-08-20 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful in the treatment of thrombolytic disease |
US5202347A (en) | 1984-03-14 | 1993-04-13 | Bodor Nicholas S | Soft β-adrenergic blocking agents |
US5000957A (en) | 1984-03-19 | 1991-03-19 | Alza Corporation | Dispenser comprising hydrophilic osmopolymer |
US4556672A (en) | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
US4701450A (en) | 1984-03-21 | 1987-10-20 | Akzo N.V. | Steroids for use as immunomodulators |
US4542155A (en) | 1984-04-02 | 1985-09-17 | E. R. Squibb & Sons, Inc. | Tetrahydrofuranyl substituted prostaglandin analogs |
US4536514A (en) | 1984-04-06 | 1985-08-20 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombolytic disease |
US4579867A (en) | 1984-04-09 | 1986-04-01 | American Hospital Supply Corporation | Stable pharmaceutical compositions of short-acting β-adrenergic receptor blocking agents |
US4550187A (en) | 1984-04-12 | 1985-10-29 | The Research Foundation Of State University Of New York | Synthesis of platinum (IV) antineoplastic agents |
US4542156A (en) | 1984-04-26 | 1985-09-17 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted prostaglandin alcohols and their use in the treatment of thrombolytic disease |
US4542157A (en) | 1984-04-27 | 1985-09-17 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease |
US4550120A (en) | 1984-04-30 | 1985-10-29 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted ethers and their use in treating thrombolytic disease |
US4569942A (en) | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
US4542151A (en) | 1984-12-17 | 1985-09-17 | E. R. Squibb & Sons, Inc. | Tetrahydrothienyl substituted ethers |
US4521539A (en) | 1984-05-10 | 1985-06-04 | E. R. Squibb & Sons, Inc. | Tetrahydrofuranyl substituted ethers |
DK240184D0 (da) | 1984-05-15 | 1984-05-15 | Ferrosan As | Beta-carboline-3-carboxylic acid derivatives and method of preparing the same |
DK240084D0 (da) | 1984-05-15 | 1984-05-15 | Ferrosan As | New beta-carboline-3-oxadiazolyl derivatives |
JPS60248659A (ja) | 1984-05-25 | 1985-12-09 | Microbial Chem Res Found | 3−〔n−(メルカプトアシル)〕アミノ−4−アリ−ル酪酸誘導体及びそれを有効成分とする鎮痛剤 |
US4579866A (en) | 1984-05-29 | 1986-04-01 | Usv Pharmaceutical Corp. | Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents |
US4560698A (en) | 1984-06-04 | 1985-12-24 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment in thrombolytic disease |
US4555523A (en) | 1984-06-04 | 1985-11-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment of thrombolytic disease |
GB8414518D0 (en) | 1984-06-07 | 1984-07-11 | Pfizer Ltd | Therapeutic agents |
US4670551A (en) | 1984-06-21 | 1987-06-02 | Ciba-Geigy Corporation | Epoxy steroids |
US5310731A (en) | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
GB8416724D0 (en) | 1984-06-30 | 1984-08-01 | Sorbio Sa Lab | Active compounds |
US4670541A (en) | 1984-07-05 | 1987-06-02 | E. R. Squibb & Sons, Inc. | Use of diamino alcohols as analgesic agents |
US4552866A (en) | 1984-07-05 | 1985-11-12 | E. R. Squibb & Sons, Inc. | Use of diamino alcohols as analgesic agents |
US4539312A (en) | 1984-07-11 | 1985-09-03 | E. R. Squibb & Sons, Inc. | Use of diamino ketones as analgesic agents |
US4594188A (en) | 1984-07-11 | 1986-06-10 | E. R. Squibb & Sons, Inc. | Use of diamino ketones as analgesic agents |
US4730052A (en) | 1984-07-13 | 1988-03-08 | Taisho Pharmaceutical Co., Ltd. | Method for preparing unsymmetrical 1,4-dihydropyridine-3,5-dicarboxylic acid diesters |
US4542160A (en) | 1984-07-30 | 1985-09-17 | E. R. Squibb & Sons, Inc. | Method of use of bicycloheptane substituted prostaglandin analogs as cardiovascular agents |
US4611066A (en) | 1984-08-10 | 1986-09-09 | Arizona State University | Bryostatins 4 to 8 |
US4845242A (en) | 1987-04-28 | 1989-07-04 | Georgia Tech Research Corporation | Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents |
US4954519A (en) | 1987-04-28 | 1990-09-04 | Georgia Tech Research Corporation | Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents |
FR2569408B1 (fr) | 1984-08-24 | 1986-10-03 | Roussel Uclaf | Nouveaux steroides substitues en position 10 par un radical comportant une double ou triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant |
WO1986001510A1 (en) | 1984-08-24 | 1986-03-13 | Pfizer Inc. | Tricyclic oxindole antiinflammatory agents |
US4567000A (en) | 1984-08-31 | 1986-01-28 | The Upjohn Company | 11-Difluoromethylene steroids |
GB8422876D0 (en) * | 1984-09-11 | 1984-10-17 | Secr Defence | Silicon implant devices |
US4711856A (en) | 1984-09-19 | 1987-12-08 | Mayo Medical Resources | Nuclear binding assay for steroid receptor functionality in cancerous cells |
US4749792A (en) | 1984-09-26 | 1988-06-07 | E. R. Squibb & Sons, Inc. | Diamino ketones and alcohols as analgesic agents |
JPS6172712U (zh) | 1984-10-12 | 1986-05-17 | ||
FR2571727B1 (fr) | 1984-10-16 | 1987-06-12 | Roussel Uclaf | Nouveaux produits steroides comportant, en position 23, un radical dihydro oxazolyle, leur procede de preparation, leur application a la preparation de produits de la serie des 20 cetopregnanes et intermediaires de cette application |
DE3438351A1 (de) | 1984-10-19 | 1986-04-24 | Gödecke AG, 1000 Berlin | 4-alkoxy-pyrido(2,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung |
US4644005A (en) | 1984-10-31 | 1987-02-17 | Pfizer Inc. | Oxindole antiinflammatory agents |
US4686224A (en) | 1984-10-31 | 1987-08-11 | Pfizer Inc. | Oxindole antiinflammatory agents |
US4575512A (en) | 1984-11-01 | 1986-03-11 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their anti-thrombotic compositions and methods |
JPS61112075A (ja) | 1984-11-05 | 1986-05-30 | Shionogi & Co Ltd | チエニルピラゾロキノリン誘導体 |
US4647585A (en) | 1984-11-08 | 1987-03-03 | E. R. Squibb & Sons, Inc. | Bicycloheptane substituted ethers |
US4650874A (en) | 1984-11-26 | 1987-03-17 | G. D. Searle & Co. | N-(aralkoxybenzyl)-4(benzhydryl) piperidines |
US4661506A (en) | 1984-11-30 | 1987-04-28 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted ox prostaglandin analogs |
US4638011A (en) | 1984-12-17 | 1987-01-20 | E. R. Squibb & Sons, Inc. | Tetrahydrothienyl substituted prostaglandin analogs |
US4892887A (en) | 1984-12-20 | 1990-01-09 | Yale University | N,N'-bis(sulfonyl)hydrazines having antineoplastic activity |
US4684747A (en) | 1984-12-20 | 1987-08-04 | Yale University | N,N'-bis(sulfonyl)hydrazines having antineoplastic activity |
FR2576025B1 (fr) | 1985-01-14 | 1987-01-23 | Roussel Uclaf | Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant |
EP0188010A1 (en) | 1985-01-14 | 1986-07-23 | Gist-Brocades N.V. | New process for the preparation of certain steroids, especially intermediates for the preparation of proligestone and related compounds, and new intermediates formed in this process |
US4588743A (en) | 1985-01-22 | 1986-05-13 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane-substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease |
US4760051A (en) | 1985-01-24 | 1988-07-26 | Pickart Loren R | Use of GHL-Cu as a wound-healing and anti-inflammatory agent |
US4588742A (en) | 1985-02-20 | 1986-05-13 | E. R. Squibb & Sons, Inc. | Thiabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease |
US4591603A (en) | 1985-02-25 | 1986-05-27 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease |
US4588741A (en) | 1985-02-28 | 1986-05-13 | E. R. Squibb & Sons, Inc. | Platelet aggregation inhibiting and bronchoconstriction inhibiting thiabicycloheptane substituted amino prostaglandin analog derivatives, compositions, and method of use therefor |
US4927828A (en) | 1985-03-08 | 1990-05-22 | The Trustees Of Princeton University | Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives |
US4684653A (en) | 1985-03-08 | 1987-08-04 | The Trustees Of Princeton University | Pyrido(2,3-d)pyrimidine derivatives |
DE3510203A1 (de) | 1985-03-21 | 1986-09-25 | Bayer Ag, 5090 Leverkusen | Neue iodpropargylether, ein verfahren zu ihrer herstellung und ihre verwendung |
US4596828A (en) | 1985-03-28 | 1986-06-24 | Merck & Co., Inc. | [(2-hydroxy-5-alkoxyphenyl)methylthio]phenylmethanol and derivatives thereof useful as anti-inflammatory agents |
US4681111A (en) * | 1985-04-05 | 1987-07-21 | Siemens-Pacesetter, Inc. | Analog and digital telemetry system for an implantable device |
US4654165A (en) * | 1985-04-16 | 1987-03-31 | Micro Tracers, Inc. | Microingredient containing tracer |
US4611007A (en) | 1985-04-22 | 1986-09-09 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease |
US4607049A (en) | 1985-04-22 | 1986-08-19 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted thio prostaglandin analogs useful in the treatment of thrombolytic disease |
US4713393A (en) | 1985-04-25 | 1987-12-15 | Merck & Co., Inc. | Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents |
US4775679A (en) | 1985-04-25 | 1988-10-04 | Merck & Co., Inc. | Certain heterocyclic-ethyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents |
US4782058A (en) | 1985-04-26 | 1988-11-01 | Pennwalt Corporation | 1,3,4,6,7,11b-Hexahydro-6-phenyl-2H-pyrazino-(2,1-a)isoquinolines, for anti-histamine or anti-depression treatment |
US4608386A (en) | 1985-04-26 | 1986-08-26 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane ethers useful in the treatment of thrombotic diseases |
US4748153A (en) | 1985-04-29 | 1988-05-31 | Merck & Co., Inc. | Compounds having somatostatin-like activity useful as local anti-inflammatory agents |
US4585755A (en) | 1985-04-29 | 1986-04-29 | Merck & Co., Inc. | Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents |
JP2617706B2 (ja) | 1985-05-01 | 1997-06-04 | 富士薬品工業 株式会社 | 3α,5−シクロ−22,23−ジヒドロキシ−5α−ステロイド化合物 |
FR2581382B1 (fr) | 1985-05-06 | 1987-06-26 | Sanofi Sa | Derives n-(quinolyl) glycinamides, leur procede de preparation et leur application therapeutique en tant que psychotropes |
US4607048A (en) | 1985-05-16 | 1986-08-19 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted aryl amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
US4595692A (en) | 1985-05-17 | 1986-06-17 | E. R. Squibb & Sons, Inc. | 7-thiabicycloheptane substituted ethers |
US4611005A (en) | 1985-05-21 | 1986-09-09 | E. R. Squibb & Sons, Inc. | 5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease |
FR2599039B1 (fr) | 1986-05-22 | 1988-08-05 | Rhone Poulenc Sante | Nouvelle substance immuno-suppressive, sa preparation par culture de streptomyces sp. (cbs 162.86) et les compositions pharmaceutiques qui la contiennent |
US4767627A (en) | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
US5202330A (en) | 1985-06-03 | 1993-04-13 | E. R. Squibb & Sons, Inc. | 2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters |
US5026712A (en) | 1985-06-05 | 1991-06-25 | Schering Ag | Novel imidazo[1,5-a]pyridines, useful as cardiovascular and CNS agents |
US4628095A (en) | 1985-06-05 | 1986-12-09 | G. D. Searle & Co. | Substituted N-benzyl-4-(benzhydryl) piperidines |
US4863955A (en) | 1985-06-06 | 1989-09-05 | Eli Lilly And Company | Scytophycins |
US4996229A (en) | 1985-06-06 | 1991-02-26 | University Of Hawaii | Scytophycins |
US4861765A (en) | 1985-06-26 | 1989-08-29 | Jouveinal | 21-alkyl-, cycloalkyl- or aryl-substituted thio steroids and pharmaceutical compositions containing them |
US4609671A (en) | 1985-06-27 | 1986-09-02 | E. R. Squibb & Sons, Inc. | 5,6-epoxy-7-oxabicycloheptane substituted amino prostaglandin analogs useful in the treatment of thrombotic disease |
US4611006A (en) | 1985-06-28 | 1986-09-09 | E. R. Squibb & Sons, Inc. | 5,6-epoxy-7-oxabicycloheptane substituted ethers useful in the treatment of thrombotic disease |
US4663336A (en) | 1985-07-01 | 1987-05-05 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease |
US4737493A (en) | 1985-07-01 | 1988-04-12 | Warner-Lambert Company | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents |
US4678802A (en) | 1985-07-09 | 1987-07-07 | Pfizer Inc. | 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents |
US4654335A (en) | 1985-07-11 | 1987-03-31 | E. R. Squibb & Sons, Inc. | Antihypertensive 1,5-benzothiazepine derivatives, compositions, and method of use therefor |
US4704382A (en) | 1985-07-29 | 1987-11-03 | G. D. Searle & Co. | Phenylpiperazine phosphonates |
US4654356A (en) | 1985-08-01 | 1987-03-31 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted diacid diamide prostaglandin analogs |
US4654355A (en) | 1985-08-01 | 1987-03-31 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs |
US4647561A (en) | 1985-08-05 | 1987-03-03 | E. R. Squibb & Sons, Inc. | 1,5-benzodiazepine compounds |
US4654357A (en) | 1985-08-09 | 1987-03-31 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted sulfonamide prostaglandin analogs |
US4923892A (en) | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
US4626548A (en) | 1985-08-19 | 1986-12-02 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted prostaglandin compounds useful in the treatment of thrombotic disease |
US4669479A (en) | 1985-08-21 | 1987-06-02 | Spring Creek Institute, Inc. | Dry electrode system for detection of biopotentials |
US4763659A (en) | 1985-08-21 | 1988-08-16 | Spring Creek Institute, Inc. | Dry electrode system for detection of biopotentials |
MC1814A1 (fr) | 1985-08-26 | 1988-03-18 | Manchak Frank | Appareil de traitement in situ de dechets dangereux et methode d'utilisation de cet appareil |
GB8521350D0 (en) | 1985-08-28 | 1985-10-02 | Euro Celtique Sa | Analgesic composition |
US5380840A (en) | 1985-09-12 | 1995-01-10 | The Upjohn Company | Triazinylpiperazinyl steroids |
US4632931A (en) | 1985-09-25 | 1986-12-30 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amide-sulfonamide prostaglandin analogs useful in the treatment of thrombotic disease |
US4686221A (en) | 1985-10-01 | 1987-08-11 | Kanebo, Ltd. | Quinolinecarboxylic acid compounds and antimicrobial agent containing the same |
US4635641A (en) | 1985-10-16 | 1987-01-13 | Murray Electronics Associates Limited | Multi-element electrode |
US4593042A (en) | 1985-10-18 | 1986-06-03 | G. D. Searle & Co. | Bicyclo-substituted phenylacetonitrile derivatives |
CA1306260C (en) | 1985-10-18 | 1992-08-11 | Shionogi & Co., Ltd. | Condensed imidazopyridine derivatives |
US4652576A (en) | 1985-10-18 | 1987-03-24 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amide-carbamate prostaglandin analogs |
US5373095A (en) | 1985-10-18 | 1994-12-13 | The Upjohn Company | Steroid compounds |
US4975537A (en) | 1985-10-23 | 1990-12-04 | The Upjohn Company | Δ9(11) -angiostatic steroids |
US4639461A (en) | 1985-10-28 | 1987-01-27 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted keto-amide prostaglandin analogs useful in the treatment of thrombotic disease |
US4638012A (en) | 1985-11-05 | 1987-01-20 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane α-substituted ketone prostaglandin analogs useful in the treatment of thrombotic disease |
DE3540653A1 (de) | 1985-11-13 | 1987-05-14 | Schering Ag | Neue 3-oxadiazol- und 3-carbonsaeure-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
US4824955A (en) | 1985-11-15 | 1989-04-25 | Nippon Kayaku Kabushiki Kaisha | Selenium oxy chloride-pyridine or bipyridine complexes |
US4647573A (en) | 1985-11-22 | 1987-03-03 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted thioamide-amide prostaglandin analogs |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US5106996A (en) | 1985-12-05 | 1992-04-21 | Bristol-Myers Company | Process for the preparation of podophyllotoxin |
US4656185A (en) | 1985-12-05 | 1987-04-07 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted aminoalkyl amide prostaglandin analogs |
US5055290A (en) | 1985-12-18 | 1991-10-08 | Boehringer Mannehim Gmbh | Ciamexone as a selective immunosuppressant |
US4618685A (en) | 1985-12-18 | 1986-10-21 | Mccully Kilmer S | N-homocysteine thiolactonyl retinamide and use thereof as an antineoplastic agent |
US4668787A (en) | 1985-12-20 | 1987-05-26 | Ortho Pharmaceutical Corporation | 5,6-dialkoxy-4-imino-2(1H)quinazolinone derivatives |
US4622326A (en) | 1985-12-23 | 1986-11-11 | Hoechst-Roussel Pharmaceuticals Inc. | 6H-isoxazolo(5,4-d)pyrazolo(3,4-b)pyridines, and their use as antihypertensive and analgesic agents |
GB8600490D0 (en) | 1986-01-09 | 1986-02-12 | Erba Farmitalia | Aminoglycoside norcholanic acid lactams |
GB8600489D0 (en) | 1986-01-09 | 1986-02-12 | Erba Farmitalia | Aminoglycoside steroids |
US4962114A (en) | 1986-01-21 | 1990-10-09 | Yale University | 1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity |
US4849563A (en) | 1986-01-21 | 1989-07-18 | Yale University | Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity |
US4772703A (en) | 1986-01-27 | 1988-09-20 | American Home Products Corporation | 2-(phenoxymethyl)-quinazolines as antiallergic and antiinflammatory agents |
US4904786A (en) | 1986-01-27 | 1990-02-27 | American Home Products Corporation | Quinoline compounds as antiallergic and antiinflammatory agents |
US4780538A (en) | 1986-02-12 | 1988-10-25 | Merck & Co., Inc. | Process for 1,4-dihydropyridine compounds using a titanamine catalyst |
US4727072A (en) | 1986-02-12 | 1988-02-23 | Mcneilab, Inc. | 3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents |
US4745123A (en) | 1986-02-18 | 1988-05-17 | Warner-Lambert Company | Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents |
US4652578A (en) | 1986-02-24 | 1987-03-24 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amide prostaglandin analogs |
US4775536A (en) | 1986-02-24 | 1988-10-04 | Bristol-Myers Company | Enteric coated tablet and process for making |
IL81610A (en) | 1986-02-27 | 1990-12-23 | Roussel Uclaf | Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them |
US4663250A (en) | 1986-03-12 | 1987-05-05 | Institute Of Gas Technology | Reduction of electrode dissolution |
US4746504A (en) | 1986-03-14 | 1988-05-24 | Bio-Technology General Corp. | Heavy metal salts of hyaluronic acid and their use as antimicrobial agents |
US4784991A (en) | 1986-03-14 | 1988-11-15 | Bio-Technology General Corp. | Heavy metal salts of hyaluronic acid and their use as antimicrobial agents |
FR2596395B1 (fr) | 1986-03-26 | 1989-05-26 | Roussel Uclaf | Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
US4663337A (en) | 1986-04-18 | 1987-05-05 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amides useful in the treatment of thrombotic disease |
US4703120A (en) | 1986-04-28 | 1987-10-27 | Ortho Pharmaceutical Corporation | Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof |
US4670560A (en) | 1986-04-28 | 1987-06-02 | Ortho Pharmaceutical Corporation | Thienopyrimidine-2,4-dione derivatives and intermediates thereof |
US4707550A (en) | 1986-04-28 | 1987-11-17 | Ortho Pharmaceutical Corporation | N-(substituted thienyl)-N'-(substituted piperazinyl)-ureas |
DE3773746D1 (en) | 1986-05-07 | 1991-11-21 | Fisons Plc | Pyrazole. |
US4670453A (en) | 1986-05-08 | 1987-06-02 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amido-carbamoyl prostaglandin analogs useful in the treatment of thrombotic disease |
US5036088A (en) | 1986-06-09 | 1991-07-30 | Pfizer Inc. | Antiallergy and antiinflammatory agents, compositions and use |
US4835166A (en) | 1986-06-09 | 1989-05-30 | Pfizer Inc. | Antiallergy and antiinflammatory agents |
US4708966A (en) | 1986-06-27 | 1987-11-24 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
US4833145A (en) | 1986-06-30 | 1989-05-23 | The Trustees Of Princeton University | 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives |
US4650797A (en) | 1986-07-18 | 1987-03-17 | E. R. Squibb & Sons, Inc. | Substituted 1,5-benzodiazepine compounds |
US4725997A (en) | 1986-08-22 | 1988-02-16 | Aprex Corporation | Contingent dosing device |
GB8620880D0 (en) | 1986-08-29 | 1986-10-08 | Pfizer Ltd | Therapeutic agents |
US4861763A (en) | 1986-09-17 | 1989-08-29 | Research Triangle Institute | 17 α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and their progestational use |
US4774236A (en) | 1986-09-17 | 1988-09-27 | Research Triangle Institute | 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them |
US4775757A (en) | 1986-09-22 | 1988-10-04 | Ortho Pharmaceutical Corporation | Thienopyridines useful as cardiovascular agents |
US4784162A (en) | 1986-09-23 | 1988-11-15 | Advanced Medical Technologies | Portable, multi-channel, physiological data monitoring system |
US4734426A (en) | 1986-09-24 | 1988-03-29 | E. R. Squibb & Sons, Inc. | 5,6-epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs |
US4734424A (en) | 1986-09-24 | 1988-03-29 | E. R. Squibb & Sons, Inc. | Bicycloheptane substituted diamide and its congener prostaglandin analogs |
US4735962A (en) | 1986-10-06 | 1988-04-05 | E. R. Squibb & Sons, Inc. | 7-thiabicycloheptane substituted diamide and its congener prostaglandin analogs |
AU607948B2 (en) | 1986-10-10 | 1991-03-21 | Aventis Pharma S.A. | 9-alpha-hydroxy steroids and process for their preparation |
US4734425A (en) | 1986-10-17 | 1988-03-29 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs |
US4782071A (en) | 1986-11-03 | 1988-11-01 | Warner-Lambert Company | Tetrasubstituted urea cholinergic agents |
US4847090A (en) | 1986-11-07 | 1989-07-11 | Warner-Lambert Company | Confection product and method for making same |
NO874194L (no) | 1986-11-07 | 1988-05-09 | Pfizer Ltd | Fremgangsmaate ved fremstilling av dihydro-pyridinderivater |
US4738978A (en) | 1986-11-10 | 1988-04-19 | E. R. Squibb & Sons, Inc. | Bisthioamide-7-oxabicycloheptane prostaglandin analogs |
US4785085A (en) | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
US4896261A (en) | 1986-11-24 | 1990-01-23 | Motorola Inc. | System for scheduling serial message transmission on a bus which is adoptable for rescheduling prioritized messages using a doubly-linked list |
FR2607816B1 (fr) | 1986-12-05 | 1989-03-31 | Roussel Uclaf | Nouveaux produits steroides comportant, en position 23, un radical sulfinyle, leur procede de preparation, leur application a la preparation de produits de la serie des 20-cetopregnanes et des intermediaires de cette preparation |
US4710508A (en) | 1986-12-08 | 1987-12-01 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
US4786648A (en) | 1986-12-08 | 1988-11-22 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
IT1213555B (it) | 1986-12-11 | 1989-12-20 | Boehringer Biochemia Srl | 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono. |
US5702688A (en) | 1986-12-23 | 1997-12-30 | Tristrata Technology, Inc. | Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use |
US4874760A (en) | 1987-01-09 | 1989-10-17 | Toa Eiyo, Ltd. | 4,7-dihydroisothiazolo(5,4-b)pyridine derivatives and cardiovascular treating agents containing said derivatives |
US5098613A (en) | 1987-01-12 | 1992-03-24 | Eli Lilly And Company | Anti-inflammatory agents |
US4945099A (en) | 1987-01-12 | 1990-07-31 | Eli Lilly And Company | Anti-inflammatory agents |
US4791129A (en) | 1987-01-20 | 1988-12-13 | Pfizer Inc. | 1,3-dicarboxamidooxindoles as analgesic and antiinflammatory agents |
US5272140A (en) | 1987-01-23 | 1993-12-21 | Akzo N.V. | 11-aryl steroid derivatives |
US4888336A (en) | 1987-01-28 | 1989-12-19 | Smithkline Beckman Corporation | Steroid 5-alpha-reductase inhibitors |
US5034548A (en) | 1987-01-30 | 1991-07-23 | E. I. Du Pont De Nemours And Company | Steroid derivatives useful as hypocholesterolemics |
US5041432A (en) | 1987-01-30 | 1991-08-20 | E. I. Du Pont De Nemours And Company | Steroid derivatives useful as hypocholesterolemics |
US5109024A (en) | 1987-02-03 | 1992-04-28 | Merrell Dow Pharmaceuticals Inc. | Polyamine derivatives as antineoplastic agents |
US4767776A (en) | 1987-02-20 | 1988-08-30 | Warner-Lambert Company | N-1H-tetrazol-5-yl-2-naphthalene carboxamides and their use as antiallergy and antiinflammatory agents |
US4764525A (en) | 1987-02-25 | 1988-08-16 | Warner-Lambert Company | N-1H-tetrazol-5-ylbenzamides having use as antiallergy and antiinflammatory agents |
US4749715A (en) | 1987-03-02 | 1988-06-07 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amino prostaglandin analogs |
US5017618A (en) | 1987-03-16 | 1991-05-21 | University Of Florida | Labile derivatives of ketone analogs of 3-substituted-1-alkylamino-2-propanols and their use as beta-adrenergic blockers |
US4798841A (en) | 1987-03-31 | 1989-01-17 | Warner-Lambert Company | Tetrahydropyridine oxime cholinergic agents and method of treatment |
US4753946A (en) | 1987-04-08 | 1988-06-28 | E. R. Squibb & Sons, Inc. | Pyrimidinecarboxylic acid derivatives |
FR2613719B1 (fr) | 1987-04-10 | 1991-03-22 | Sanofi Sa | Derives aromatiques, leur preparation et leur utilisation comme antimicrobiens |
US5002955A (en) | 1987-04-23 | 1991-03-26 | Hoechst-Roussel Pharmaceuticals Inc. | Fused heteroalkylene quinolinamines and use as cholinergic agents |
US5219873A (en) | 1987-04-24 | 1993-06-15 | Roussel Uclaf | Compounds of 1,2,5,6-tetrahydropyridine which are useful as cholinergic agents |
US5324648A (en) | 1987-04-28 | 1994-06-28 | Georgia Tech Research Corporation | Substituted isocoumarins as serine protease inhibitors and anti-inflammatory agents |
US5041433A (en) | 1987-04-29 | 1991-08-20 | Smithkline Beecham Corporation | 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase |
US4910226A (en) | 1987-04-29 | 1990-03-20 | Smithkline Beckman Corporation | Steroid 5-alpha-reductase inhibitors |
US4769371A (en) | 1987-05-01 | 1988-09-06 | E. R. Squibb & Sons, Inc. | Dihydropyrimidine carboxylic acid esters |
US4912248A (en) | 1987-05-18 | 1990-03-27 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
GB8711802D0 (en) | 1987-05-19 | 1987-06-24 | Fujisawa Pharmaceutical Co | Dithioacetal compounds |
US4888434A (en) | 1987-05-26 | 1989-12-19 | Dow Corning K.K. | Antimicrobial agent |
US5019390A (en) | 1987-05-29 | 1991-05-28 | Research Corporation Technologies, Inc. | Anticancer agent--IMIC |
GB8712747D0 (en) | 1987-05-30 | 1987-07-01 | Pfizer Ltd | Therapeutic agents |
US5081147A (en) | 1990-03-15 | 1992-01-14 | Allergan, Inc. | 4-(1-hydroxy-2-substituted amino)ethyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents |
US5298633A (en) | 1987-06-08 | 1994-03-29 | Allergan, Inc. | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents |
US5037811A (en) | 1990-04-17 | 1991-08-06 | Allergan, Inc. | 4-(oxygen, sulfur or nitrogen substituted)-methyl 5-hydroxy-2(5H)-furanones as anti-inflammatory agents |
US5043457A (en) | 1990-04-17 | 1991-08-27 | Allergan, Inc. | 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents |
US4889866A (en) | 1987-06-11 | 1989-12-26 | Syntex (U.S.A.) Inc. | Arylsulfonyl dihydropyridine derivatives |
US4752616A (en) | 1987-06-29 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use |
US4876093A (en) | 1987-07-02 | 1989-10-24 | Alza Corporation | Dispenser with dispersing member for delivering beneficial agent |
GB8716278D0 (en) | 1987-07-10 | 1987-08-19 | Fujisawa Pharmaceutical Co | Antimicrobial agent |
US4980365A (en) | 1987-07-13 | 1990-12-25 | Hoechst-Roussel Pharmaceuticals Inc. | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents |
US5008264A (en) | 1987-07-13 | 1991-04-16 | Hoechst-Roussel Pharmaceuticals Inc. | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents |
US5030639A (en) | 1987-07-13 | 1991-07-09 | Hoechst-Roussel Pharmaceuticals Inc. | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents |
CA1322199C (en) | 1987-07-15 | 1993-09-14 | Masami Eigyo | N-¬(2-oxopyrrolidin-1-yl) acetyl)| piperazine derivatives and drug for senile dementia |
DE3723310A1 (de) | 1987-07-15 | 1989-01-26 | John Urquhart | Pharmazeutisches praeparat und verfahren zu seiner herstellung |
PL154186B1 (en) | 1987-07-15 | 1991-07-31 | Wellcome Found | Method for manufacturing arylic derivatives of the hydroxamic acid |
GB8716971D0 (en) | 1987-07-17 | 1987-08-26 | Pfizer Ltd | Therapeutic agents |
US4767756A (en) | 1987-07-17 | 1988-08-30 | E. R. Squibb & Sons, Inc. | 3-substituted benzazepines |
US4794110A (en) | 1987-07-20 | 1988-12-27 | Hoechst-Roussel Pharmaceuticals, Inc. | 5-Aryl-11-substituted-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepined as analgesic and hypotensive agents |
US4771047A (en) | 1987-07-27 | 1988-09-13 | E. R. Squibb & Sons, Inc. | Benzazepine derivatives |
US4847290A (en) | 1987-08-17 | 1989-07-11 | Sumner Burstein | Delta 1-thc-7-oic acid and analgesic and anti-inflammatory agents |
CA1305148C (en) | 1987-08-19 | 1992-07-14 | Hiromu Matsumura | Carbamoylpyrrolidone derivatives and drugs for senile dementia |
US4774239A (en) | 1987-08-26 | 1988-09-27 | E. R. Squibb & Sons, Inc. | Benzazepine derivatives |
US4814181A (en) | 1987-09-03 | 1989-03-21 | Alza Corporation | Dosage form comprising fast agent delivery followed by slow agent delivery |
US4891223A (en) | 1987-09-03 | 1990-01-02 | Air Products And Chemicals, Inc. | Controlled release delivery coating formulation for bioactive substances |
FR2620704B1 (fr) | 1987-09-17 | 1991-04-26 | Sanofi Sa | Derives de (benzyl-4 piperidino)-1 propanol-2, leur preparation, leur utilisation comme antimicrobiens et les produits les contenant |
FR2620707B1 (fr) | 1987-09-18 | 1989-12-08 | Roussel Uclaf | Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
US4942236A (en) | 1987-09-30 | 1990-07-17 | American Home Products Corporation | 2-aryl substituted pyridyl-containing phenyl sulfonamido compounds as antiallergic and antiinflammatory agents |
US4895953A (en) | 1987-09-30 | 1990-01-23 | American Home Products Corporation | 2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
US4826990A (en) | 1987-09-30 | 1989-05-02 | American Home Products Corporation | 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
FR2621316B1 (fr) | 1987-10-02 | 1991-06-21 | Nativelle Sa Ets | Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant |
US4927807A (en) | 1987-10-06 | 1990-05-22 | Abbott Laboratories | Glaucoma treatment |
US5346887A (en) | 1987-10-06 | 1994-09-13 | Abbott Laboratories | Glaucoma treatment |
US5654484A (en) | 1987-10-08 | 1997-08-05 | Merrell Pharmaceuticals Inc. | Polyamine derivatives as antineoplastic agents |
US4874855A (en) | 1987-11-04 | 1989-10-17 | Dainippon Ink And Chemicals, Inc. | Steroid compounds and process of preparing the same |
GB8726950D0 (en) | 1987-11-18 | 1987-12-23 | Boots Co Plc | Chemical process |
US5266562A (en) | 1987-11-19 | 1993-11-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Anti-inflammatory agents |
US4847303A (en) | 1987-11-23 | 1989-07-11 | The Procter & Gamble Company | Tert-butylphenyl compounds useful as anti-inflammatory agents |
US5055466A (en) | 1987-11-23 | 1991-10-08 | E. R. Squibb & Sons, Inc. | N-morpholino derivatives and their use as anti-hypertensive agents |
US4883872A (en) | 1987-11-25 | 1989-11-28 | E. R. Squibb & Sons, Inc. | 3-oxo-1,2,4-triazolo(4,3-A) pyrimidine-6-carboxylic acid esters |
US4847379A (en) | 1987-11-30 | 1989-07-11 | E. R. Squibb & Sons, Inc. | 3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters |
US4910192A (en) | 1987-12-04 | 1990-03-20 | Sri International | Topically active steroidal anti-inflammatory agents |
HUT58275A (en) | 1987-12-11 | 1992-02-28 | Mitsui Petrochemical Ind | Process for producing amines and pharmaceutical compositions containing them |
US4870210A (en) | 1987-12-18 | 1989-09-26 | American Home Products Corporation | Aminoguanidine derivative as anti-inflammatory agents |
US4824831A (en) | 1987-12-21 | 1989-04-25 | E. R. Squibb & Sons, Inc. | 4,5-dihydro-1H-benzazepine-3-carboxylic acid esters which are useful as anti-hypertensive agents |
DE3876769T2 (de) | 1987-12-23 | 1993-06-09 | Roussel Uclaf | Mikrobiologische herstellung von 9-alpha-hydroxy-17-keto-steroiden. |
JPH01294683A (ja) | 1988-02-04 | 1989-11-28 | Kanebo Ltd | 新規白金錯体および該化合物を有効成分とする抗腫瘍剤並びに該化合物製造用中間体 |
US4889859A (en) | 1988-02-05 | 1989-12-26 | The Trustees Of Princeton University | Pyrido[2,3-d]pyrimidine derivatives |
GB8803259D0 (en) | 1988-02-12 | 1988-03-09 | Zambeletti Spa L | Compounds |
GB8803963D0 (en) | 1988-02-19 | 1988-03-23 | Pfizer Ltd | Therapeutic agents |
GB8804439D0 (en) | 1988-02-25 | 1988-03-23 | Pfizer Ltd | Dihydropyridines |
US5217958A (en) | 1988-03-03 | 1993-06-08 | E. R. Squibb & Sons, Inc. | 1,2-hydroxy phosphonates and derivatives thereof |
US4900748A (en) | 1988-03-04 | 1990-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Carbamates related to (-)-physostigmine as cholinergic agents |
GB2216515A (en) | 1988-03-04 | 1989-10-11 | Nippon Shinyaku Co Ltd | Acylphenol derivatives |
US4906634A (en) | 1988-03-08 | 1990-03-06 | Schering A.G. | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents |
US4835157A (en) | 1988-03-15 | 1989-05-30 | Ortho Pharmaceutical Corporation | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents |
US4900552A (en) | 1988-03-30 | 1990-02-13 | Watson Laboratories, Inc. | Mucoadhesive buccal dosage forms |
US4981843A (en) | 1988-04-07 | 1991-01-01 | E. R. Squibb & Sons, Inc. | N-heterocyclic alcohol derivatives |
US5194602A (en) | 1988-04-08 | 1993-03-16 | Gist-Brocades N.V. | 9α-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids |
US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
JPH01285247A (ja) | 1988-05-12 | 1989-11-16 | Olympus Optical Co Ltd | 医療用カプセル |
US4868167A (en) | 1988-05-20 | 1989-09-19 | University Of Pittsburgh | Novel peptidyl amino steroids |
US4970318A (en) | 1988-05-24 | 1990-11-13 | Pfizer Inc. | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
US4882334A (en) | 1988-05-25 | 1989-11-21 | The Trustees Of Princeton University | N-(5,6,7,8-tetrahydropyrido]2,3-d]pyrimidin-6-ylethl-thineyl-and furylcarbonyl)-glutamic acid derivatives |
US4882333A (en) | 1988-05-25 | 1989-11-21 | The Trustess Of Princeton University | N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives |
US5208250A (en) | 1988-05-25 | 1993-05-04 | Warner-Lambert Company | Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents |
US5306822A (en) | 1988-05-25 | 1994-04-26 | Warner-Lambert Company | Arylmethylenyl derivatives of oxazolidinone |
US4954446A (en) | 1988-05-25 | 1990-09-04 | Smithkline Beecham Corporation | Aromatic steroid 5-α-reductase inhibitors |
US5096892A (en) | 1988-05-27 | 1992-03-17 | The Children's Medical Center Corporation | Arylsulfatase inhibition and potentiation of angiostatic steroids and heparin |
US5002772A (en) | 1988-05-31 | 1991-03-26 | Pfizer Inc. | Gastric retention system for controlled drug release |
US4871746A (en) | 1988-05-31 | 1989-10-03 | The Trustees Of Princeton University | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors |
US4857644A (en) | 1988-06-09 | 1989-08-15 | American Home Products Corporation | Aryl sulfonopiperazines as anti-inflammatory agents |
US5273066A (en) | 1988-06-10 | 1993-12-28 | Graham Neil B | Control valves and method of plant growing using flow control |
CA1327838C (fr) * | 1988-06-13 | 1994-03-15 | Fred Zacouto | Dispositif implantable de protection contre les affections liees a la coagulation sanguine |
US4975230A (en) | 1988-06-17 | 1990-12-04 | Vapor Technologies Inc. | Method of making an open pore structure |
US5245332A (en) * | 1988-06-22 | 1993-09-14 | Iedsco Oy | Programmable memory for an encoding system |
US4981792A (en) | 1988-06-29 | 1991-01-01 | Merck & Co., Inc. | Immunosuppressant compound |
US5290772A (en) | 1988-06-29 | 1994-03-01 | Merck & Co., Inc. | Immunosuppressant agent |
JPH0211501A (ja) | 1988-06-30 | 1990-01-16 | Chisso Corp | 抗菌剤組成物 |
ATE124416T1 (de) | 1988-07-05 | 1995-07-15 | Kuraray Co | Steroid-verbindungen. |
US5051423A (en) | 1988-07-13 | 1991-09-24 | Schering Ag | Derivatized alkanolamines as cardiovascular agents |
US4888335A (en) | 1988-07-25 | 1989-12-19 | Mcneilab, Inc. | 3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents |
US5232939A (en) | 1988-07-26 | 1993-08-03 | Sankyo Company Limited | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents |
US5354768A (en) | 1988-07-26 | 1994-10-11 | Sankyo Company, Limited | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents |
US5665752A (en) | 1988-07-26 | 1997-09-09 | Sankyo Company, Limited | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents |
US4977144A (en) | 1988-08-02 | 1990-12-11 | Ciba-Geigy Corporation | Imidazo[4,5-b]pyridine derivatives as cardiovascular agents |
US5175160A (en) | 1988-08-09 | 1992-12-29 | Daiichi Pharmaceutical Co., Ltd. | Antimicrobial agent for animals |
US5691346A (en) | 1988-08-10 | 1997-11-25 | The Australian National University | Castanospermine as an anti-inflammatory and immunosuppressant agent |
DE3828588C1 (zh) | 1988-08-23 | 1989-12-07 | Alcatel Hochvakuumtechnik Gmbh, 6980 Wertheim, De | |
US4844076A (en) | 1988-08-26 | 1989-07-04 | The Johns Hopkins University | Ingestible size continuously transmitting temperature monitoring pill |
DE3829524A1 (de) | 1988-08-31 | 1990-03-01 | Behringwerke Ag | Verwendung von transglutaminasen als immunsuppressiva |
JPH0635464B2 (ja) | 1988-09-02 | 1994-05-11 | 明治製菓株式会社 | 新規セフェム化合物、その製造法及び抗菌剤 |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
EP0436020A4 (en) | 1988-09-14 | 1992-03-25 | Yoshitomi Pharmaceutical Industries, Ltd. | Immunosuppressant |
US5185362A (en) | 1988-09-14 | 1993-02-09 | Mcneilab, Inc. | Diphenylamine cardiovascular agents, compositions and use |
US5073570A (en) | 1988-09-14 | 1991-12-17 | Lonza Inc. | Mono-iodopropargyl esters of dicarboxylic anhydrides and their use as antimicrobial agents |
DE3832303A1 (de) | 1988-09-20 | 1990-04-12 | Schering Ag | 11ss-phenyl-14ssh-steroide |
JPH02111766A (ja) | 1988-10-20 | 1990-04-24 | Taiho Yakuhin Kogyo Kk | ベンゾチアジアゼピン誘導体及びその塩 |
US4882322A (en) | 1988-10-27 | 1989-11-21 | Merrell Dow Pharmaceuticals Inc. | 3β,17β-hydroxy-substituted steroids and related steroidal compounds |
US5006542A (en) | 1988-10-31 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use |
US5371078A (en) | 1988-10-31 | 1994-12-06 | Alcon Laboratories, Inc. | Angiostatic steroids and methods and compositions for controlling ocular hypertension |
US4959383A (en) | 1988-10-31 | 1990-09-25 | E. R. Squibb & Sons, Inc. | Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use |
US5070099A (en) | 1988-10-31 | 1991-12-03 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use |
US4883811A (en) | 1988-11-17 | 1989-11-28 | Misra Raj N | 7-Oxabicycloheptane imino interphenylene substituted prostaglandin analogs useful in the treatment of thrombotic disease |
US5155122A (en) | 1988-11-29 | 1992-10-13 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxy-phenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents |
US5256680A (en) | 1988-11-29 | 1993-10-26 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxy-phenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents |
US4897397A (en) | 1988-12-16 | 1990-01-30 | Schering Corporation | Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents |
US5026882A (en) | 1988-12-23 | 1991-06-25 | Smithkline Beecham Corporation | Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase |
US4882319A (en) | 1988-12-23 | 1989-11-21 | Smithkline Beckman Corporation | Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase |
US4937237A (en) | 1988-12-23 | 1990-06-26 | Smithkline Beckman Corporation | Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase |
US4946834A (en) | 1988-12-23 | 1990-08-07 | Smithkline Beecham Corporation | Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors |
US4970205A (en) | 1988-12-23 | 1990-11-13 | Smithkline Beecham Corporation | Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase |
JPH02178263A (ja) | 1988-12-27 | 1990-07-11 | Kaken Pharmaceut Co Ltd | アザアズレン誘導体、その製造法およびそれを有効成分とする抗アレルギー剤および抗炎症剤 |
JPH02180265A (ja) | 1988-12-28 | 1990-07-13 | Nippon Eranko Kk | カプセル充填装置 |
US5013751A (en) | 1989-01-10 | 1991-05-07 | Alcon Laboratories, Inc. | (+) Suprofen esters and amides as opthalmic anti-inflammatory agents |
US4906655A (en) | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
JP2694361B2 (ja) | 1989-02-09 | 1997-12-24 | アストラ アクチエボラグ | 抗菌剤 |
US5084281A (en) | 1989-02-14 | 1992-01-28 | Dillon Richard S | Method and solution for treating tissue wounds |
US4954526A (en) | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
US5540931A (en) | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
SE466684B (sv) | 1989-03-07 | 1992-03-23 | Draco Ab | Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator |
US4981870A (en) | 1989-03-07 | 1991-01-01 | Pfizer Inc. | Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants |
HU203769B (en) | 1989-03-09 | 1991-09-30 | Richter Gedeon Vegyeszet | Process for producing new steroide derivatives and pharmaceutical compositions containing them |
HU203562B (en) | 1989-03-09 | 1991-08-28 | Richter Gedeon Vegyeszet | Process for producing new steroide diols and pharmaceutical compositions containing them |
DE69015393T2 (de) | 1989-03-15 | 1995-06-01 | Merck & Co Inc | Immunosuppressives Mittel. |
FR2644789B1 (fr) | 1989-03-22 | 1995-02-03 | Roussel Uclaf | Nouveaux steroides 19-nor, 3-ceto comportant une chaine en 17 aminosubstituee, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
US4952692A (en) | 1989-04-04 | 1990-08-28 | E. R. Squibb & Sons, Inc. | Benzazepine derivatives |
DE58908945D1 (de) | 1989-04-10 | 1995-03-09 | Pacesetter Ab | Implantierbares medizinisches Gerät mit Mitteln zum telemetrischen Übertragen von Daten. |
US5068323A (en) | 1989-04-21 | 1991-11-26 | Merck & Co., Inc. | Thermally re-arranged FK-506 derivatives having immunosuppressant activity |
IT1230145B (it) | 1989-05-05 | 1991-10-14 | Boehringer Biochemia Srl | Complessi di rutenio (iii) come agenti antineoplastici. |
CA2016517C (en) | 1989-05-11 | 1999-01-12 | Dale R. Shackle | Solid state electrochemical cell having microroughened current collector |
US4980385A (en) | 1989-05-22 | 1990-12-25 | Basf Corporation | Polyurethane/polycarbonate compatibility |
DE3917274A1 (de) | 1989-05-24 | 1990-11-29 | Schering Ag | 9(alpha)-hydroxy-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
US4981865A (en) | 1989-05-26 | 1991-01-01 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
US5075330A (en) | 1989-05-26 | 1991-12-24 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, N-hydroxyurea, and N-hydroxythiourea derivatives of selected NSAIDS as antiinflammatory agents |
US5112846A (en) | 1989-05-26 | 1992-05-12 | Warner-Lambert Company | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
US5140031A (en) | 1989-05-31 | 1992-08-18 | E. R. Squibb & Sons, Inc. | Pyranyl cyanoguanidine derivatives |
FI902771A0 (fi) | 1989-06-09 | 1990-06-04 | Warner Lambert Co | Foerfarande foer framstaellning av antiinflammatoriska 1,3,4-tiadiazoler och 1,3,4-oxadiazoler. |
US5017578A (en) | 1989-06-09 | 1991-05-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents |
US5066668A (en) | 1989-06-09 | 1991-11-19 | Warner-Lambert Co. | Triazole derivatives of fenamates as antiinflammatory agents |
US4962119A (en) | 1989-06-09 | 1990-10-09 | Warner-Lambert Company | Triazole derivatives of fenamates as antiinflammatory agents |
US5104656A (en) | 1989-06-16 | 1992-04-14 | Seth Pyare L | Percutaneous treatment with a high potency non-steroidal anti-inflammatory agent |
US4931457B1 (en) | 1989-06-28 | 1993-11-16 | Hoechst-Roussel Pharmaceuticals Incorporated | Naphthylamino-and naphthyloxy-pyridineamin compounds useful as topical antiinflammatory agents for the treatment of skin disorders |
US4939137A (en) | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
US5116867A (en) | 1989-06-30 | 1992-05-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | D-propranolol as a selective adenosine antagonist |
US5068247A (en) | 1989-07-07 | 1991-11-26 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-aminopentanoic acid compounds and their use as immunosuppressants |
US5281287A (en) | 1989-07-21 | 1994-01-25 | Iomed, Inc. | Method of making a hydratable bioelectrode |
EP0412699B1 (en) | 1989-08-07 | 1994-04-27 | Takeda Chemical Industries, Ltd. | Nitrosothiol derivatives, their production and use |
US4904674A (en) | 1989-08-16 | 1990-02-27 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(Benzo[b]thienyl)-2-(thienyl)ethenes and related compounds useful as anti-inflammatory agents |
US5032586A (en) | 1989-08-24 | 1991-07-16 | Smithkline Beecham Corporation | 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase |
US5252745A (en) | 1989-08-25 | 1993-10-12 | Rohm And Haas Company | Preparation and use of iodopropargyl esters of α-amino acid derivatives as antimicrobial agents |
US4988710A (en) | 1989-08-25 | 1991-01-29 | Washington University | Aryl-cycloalkyl-alkanolamines for treatment of cholinergic neurotoxins |
US5077404A (en) | 1989-08-29 | 1991-12-31 | Piper James R | Cyclized 5,10-dideazaaminopterin compounds |
US5214068A (en) | 1989-09-06 | 1993-05-25 | Yale University | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents |
US5101072A (en) | 1989-09-06 | 1992-03-31 | Yale University | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents |
US4966967A (en) | 1989-09-15 | 1990-10-30 | Berlex Laboratories, Inc. | 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents |
GB8920957D0 (en) | 1989-09-15 | 1989-11-01 | Hitech Metal Detectors Ltd | Metal detecting apparatus and apparatus for testing metal detecting apparatus |
US4987897A (en) | 1989-09-18 | 1991-01-29 | Medtronic, Inc. | Body bus medical device communication system |
US4970226A (en) | 1989-10-03 | 1990-11-13 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents |
US5071848A (en) | 1989-10-23 | 1991-12-10 | Abbott Laboratories | Tricyclic quinoline antineoplastic agents |
US5037835A (en) | 1989-10-24 | 1991-08-06 | Hoechst-Roussel Pharmaceuticals Inc. | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders |
US4959378A (en) | 1989-10-24 | 1990-09-25 | Hoechst-Roussel Pharmaceuticals Inc. | Aminopyridinylaminophenol compounds useful as topical antiinflammatory agents for the treatment of skin disorders |
US4992448A (en) | 1989-10-24 | 1991-02-12 | Hoechst-Roussel Pharmaceuticals Inc. | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders |
DK0425016T3 (da) | 1989-10-27 | 1996-05-06 | Genencor Int | Antimikrobiel fremgangsmåde og formulering med anvendelse af type II endoglycosidase og antimikrobielt middel |
FR2653767B1 (fr) | 1989-10-30 | 1992-02-14 | Lafon Labor | Derives de 1-(aminophenyl)-2-piperidinopropanone, procede et utilisation en therapeutique. |
US4988728A (en) | 1989-11-03 | 1991-01-29 | Alcon Laboratories, Inc. | Suprofen esters and amides as ophthalmic anti-inflammatory agents |
US5064837A (en) | 1989-11-13 | 1991-11-12 | Schering Corporation | 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions |
US5208228A (en) | 1989-11-13 | 1993-05-04 | Merck & Co., Inc. | Aminomacrolides and derivatives having immunosuppressive activity |
US5215972A (en) | 1989-11-22 | 1993-06-01 | Hoffmann-La Roche Inc. | Steroids |
GB8926512D0 (en) | 1989-11-23 | 1990-01-10 | Pfizer Ltd | Therapeutic agents |
GB9024617D0 (en) | 1989-12-05 | 1991-01-02 | Ici Plc | Heterocyclic compounds |
US5028608A (en) | 1989-12-11 | 1991-07-02 | The Trustees Of Princeton University | N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives |
US5110441A (en) | 1989-12-14 | 1992-05-05 | Monsanto Company | Solid state ph sensor |
US5491136A (en) | 1989-12-20 | 1996-02-13 | Merrell Dow Pharmaceuticals Inc. | 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, 19-hydroxylaser inhibitors and methods of their use in the treatment of estrogen mediated disorders |
US5099037A (en) | 1989-12-20 | 1992-03-24 | Merrell Dow Pharmaceuticals Inc. | 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase and 19-hydroxylase inhibitors |
US5095037B1 (en) | 1989-12-21 | 1995-12-19 | Nissho Kk | Combined anti-inflammatory agent |
FR2656310B1 (fr) | 1989-12-22 | 1992-05-07 | Roussel Uclaf | Nouveaux produits sterouides comportant en position 10, un radical thioethyle substitue, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
FR2656309B1 (fr) | 1989-12-22 | 1992-05-07 | Roussel Uclaf | Nouveaux produits sterouides comportant en position 10, un radical ethyle substitue, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
DE4003410A1 (de) * | 1990-02-05 | 1991-08-08 | Anatoli Stobbe | Tragbares feldprogrammierbares detektierplaettchen |
GB9003939D0 (en) | 1990-02-21 | 1990-04-18 | Imperial College | Sulphatase inhibitors |
FR2658516B1 (fr) | 1990-02-22 | 1992-06-12 | Roussel Uclaf | Nouveaux produits sterouides comportant un radical spiro en position 17, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
US5219879A (en) | 1990-03-05 | 1993-06-15 | Du Pont Merck Pharmaceutical Company | Heterocyclic steroid compounds |
US5064835A (en) | 1990-03-01 | 1991-11-12 | Merck & Co., Inc. | Hydroxymacrolide derivatives having immunosuppressive activity |
US5306718A (en) | 1990-03-06 | 1994-04-26 | Warner-Lambert Company | Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment |
US5346911A (en) | 1990-03-06 | 1994-09-13 | Warner-Lambert Company | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment |
US5360811A (en) | 1990-03-13 | 1994-11-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents |
DE69108014T2 (de) | 1990-03-13 | 1995-07-06 | Acic Canada Inc | Verfahren zur herstellung von nucleosiden und ihre analogen. |
US5091430A (en) | 1990-03-13 | 1992-02-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | O6 -substituted guanine compounds and methods for depleting O6 -alkylguanine-DNA alkyltransferase levels |
US5079247A (en) | 1990-03-14 | 1992-01-07 | American Cyanamid Company | N1 -substituted benz(cd)indol-2-imine compounds as cardiovascular agents |
US5212172A (en) | 1990-03-15 | 1993-05-18 | Allergan, Inc. | 4-(1-hydroxy-2-substituted amino)ethyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents |
US5574041A (en) | 1990-03-16 | 1996-11-12 | Beth Israel Hospital Association | Use of spiperone derivatives as immunosuppressant agents |
CA2077907C (en) | 1990-03-16 | 1998-06-09 | Richard J. Sharpe | Use of spiperone as an immunosuppressant and anti-inflammatory agent |
US5223516A (en) | 1990-03-22 | 1993-06-29 | E. R. Squibb & Sons, Inc. | 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same |
US5081261A (en) | 1990-03-23 | 1992-01-14 | Allergan, Inc. | 4-(1-hydroxy-2-N-substituted sulfonamido) ethyl-5-hydroxy-2(5H)-furanones and 4-(N-substituted sulfonamido)-2-ethenyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents |
US5143928A (en) | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
US5086064A (en) | 1990-03-27 | 1992-02-04 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl thiazolyl, oxazolyl, and imidazolyl methanones and related compounds as antiinflammatory agents |
US5234937A (en) | 1990-03-27 | 1993-08-10 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxphenyl oxazolyl methanones and related compounds as antiinflammatory agents |
US5234939A (en) | 1990-03-27 | 1993-08-10 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl imidazolyl methanones and related compounds as antiinflammatory agents |
US5013850A (en) | 1990-03-30 | 1991-05-07 | Allergan, Inc. | 4-ethyl and 4-ethenyl-5-hydroxy-2(5H)-furanones substituted on alpha carbon of the ethyl or ethenyl side chain with a long chain alkyl group and on the beta carbon with a polar group, as anti-inflammatory agents |
US5061813A (en) | 1990-04-02 | 1991-10-29 | E. R. Squibb & Sons, Inc. | Substituted cyanoimino benzopyranes |
US5116829A (en) | 1990-04-23 | 1992-05-26 | Kao Corporation | Steroid compounds |
US5198449A (en) | 1990-04-27 | 1993-03-30 | A. H. Robins Company Incorporated | N-substituted alpha-arylazacycloalkylmethanamines and their use as cardiovascular agents |
EP0528906B1 (en) | 1990-04-30 | 1995-10-11 | The Board Of Regents, The University Of Texas System | STEROID 5$g(a)-REDUCTASES |
US5018813A (en) | 1990-05-01 | 1991-05-28 | Eastman Kodak Company | Multichannel integrated optic modulator for laser printer |
JPH0413679A (ja) | 1990-05-07 | 1992-01-17 | Wakunaga Pharmaceut Co Ltd | 新規ジヒドロピリジン誘導体 |
US5260444A (en) | 1990-05-07 | 1993-11-09 | Wakunaga Seiyaku Kabushiki Kaisha | Dihydropyridine derivative |
US5213738A (en) | 1990-05-15 | 1993-05-25 | L. Perrigo Company | Method for making a capsule-shaped tablet |
US6749122B1 (en) | 1990-05-25 | 2004-06-15 | Broadcom Corporation | Multi-level hierarchial radio-frequency system communication system |
US6359872B1 (en) | 1997-10-28 | 2002-03-19 | Intermec Ip Corp. | Wireless personal local area network |
EP0458160A3 (en) | 1990-05-25 | 1992-03-18 | Sociedad Espanola De Especialidades Farmaco-Terapeuticas, S.A. | Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents |
DE4017780A1 (de) | 1990-06-01 | 1991-12-05 | Sensoplan Messtechnik Gmbh | Vorrichtung zum feststellen von relativ zu einer metallempfindlichen sensoranordnung bewegten metallteilen |
US5256408A (en) | 1990-06-12 | 1993-10-26 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
US5252319A (en) | 1990-06-12 | 1993-10-12 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
US5209926A (en) | 1990-06-12 | 1993-05-11 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
US5036070A (en) | 1990-06-13 | 1991-07-30 | American Home Products Corporation | Polycyclic phenalkyl amines as psychotropic agents |
DE4019024A1 (de) | 1990-06-14 | 1991-12-19 | Bayer Ag | Verwendung der efomycine a, e und g als entzuendungshemmende mittel |
US5189036A (en) | 1990-06-20 | 1993-02-23 | Schering Ag | Imidazolylbenzoyl substituted heterocycles |
US5192773A (en) | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
DE4021433A1 (de) | 1990-07-04 | 1992-01-09 | Schering Ag | Antiandrogene mit steroid(3,2-c)pyrazol-struktur |
US5073560A (en) | 1990-07-20 | 1991-12-17 | Fisons Corporation | Spiro-isoxazolidine derivatives as cholinergic agents |
US5211937A (en) | 1990-07-30 | 1993-05-18 | Glycomed Incorporated | Method of determining a site of inflammation utilizing elam-1 ligands |
JPH04364160A (ja) | 1990-08-03 | 1992-12-16 | Terumo Corp | チオウレア誘導体およびこれを含有する抗菌剤および抗潰瘍剤 |
US5124455A (en) | 1990-08-08 | 1992-06-23 | American Home Products Corporation | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents |
US5399553A (en) | 1990-08-09 | 1995-03-21 | Wakunaga Seiyaku Kabushiki Kaisha | Tricyclic compound or salts thereof, method for producing the same and anti-microbial agent containing the same |
KR920004385A (ko) | 1990-08-09 | 1992-03-27 | 와꾸나가 기스께 | 신규 삼환화합물 또는 그의 염, 이의 제조방법 및 이를 함유하는 항균제 |
US5302592A (en) | 1990-08-17 | 1994-04-12 | Rohm And Haas Company | Use of substituted 3-thioacryloyl compounds as antimicrobial agents |
US5308837A (en) | 1990-08-22 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | 5'-amine substituted adenosine analogs as immunosuppressants |
US5318965A (en) | 1990-08-24 | 1994-06-07 | Abbott Laboratories | Quinobenzoxazine, antineoplastic agents |
US5059602A (en) | 1990-08-27 | 1991-10-22 | Hoechst-Roussel Pharmaceuticals Inc. | 4-substituted dihydropyrido(4,3-d)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders |
US5095019A (en) | 1990-08-27 | 1992-03-10 | Hoechst-Roussel Pharmaceuticals Inc. | 4-substituted dihydropyrido(4,3-D)pyrimidines as analgesics and topical antiinflammatory agents for the treatment of skin disorders |
US5091528A (en) | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
US5514688A (en) | 1990-09-14 | 1996-05-07 | Merrell Dow Pharmaceuticals Inc. | Carbocyclic adenosine analogs useful as immunosuppressants |
US5470857A (en) | 1990-09-14 | 1995-11-28 | Marion Merrell Dow Inc. | Carbocyclic nucleoside analogs useful as immunosuppressants |
US5244896A (en) | 1990-09-14 | 1993-09-14 | Marion Merrell Dow Inc. | Carbocyclic adenosine analogs useful as immunosuppressants |
US5096700A (en) | 1990-09-28 | 1992-03-17 | The Procter & Gamble Company | Halogenated aminohexanoates and aminobutyrates antimicrobial agents |
US5167626A (en) | 1990-10-02 | 1992-12-01 | Glaxo Inc. | Medical capsule device actuated by radio-frequency (RF) signal |
US5216165A (en) | 1990-10-03 | 1993-06-01 | American Home Products Corporation | N-substituted aminoquinolines as analgesic agents |
JPH0764841B2 (ja) | 1990-10-03 | 1995-07-12 | ファイザー製薬株式会社 | インドール誘導体およびその用途 |
US5143918A (en) | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
DE4033415A1 (de) | 1990-10-20 | 1992-04-23 | Bayer Ag | Antimikrobielle mittel sowie substituierte 2-cyclohexan-1-yl-amin-derivate und deren herstellung |
DE4038128A1 (de) | 1990-11-27 | 1992-06-04 | Schering Ag | 8-en-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
US5166201A (en) | 1990-11-30 | 1992-11-24 | Merrell Dow Pharmaceuticals Inc. | 2β,19-ethylene bridged steroids as aromatase inhibitors |
US5126488A (en) | 1990-11-30 | 1992-06-30 | Merrell Dow Pharmaceuticals Inc. | 2β,19-methyleneamino bridged steroids as aromatase inhibitors |
CA2094123A1 (en) | 1990-12-07 | 1992-06-08 | Pharmacia & Upjohn Company Llc | Phosphonic acid derivatives useful as antiinflammatory agents |
US5209930A (en) | 1990-12-10 | 1993-05-11 | Rohm And Haas Company | Preparation and use of n-iodopropargyl oxycarbonyl amino acid esters and derivatives as antimicrobial agents |
US5883087A (en) | 1991-01-07 | 1999-03-16 | Pherin Corporation | Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
JP2528741B2 (ja) | 1991-01-09 | 1996-08-28 | ファイザー製薬株式会社 | オキサゾ―ル、チアゾ―ルおよびイミダゾ―ル化合物 |
AU646722B2 (en) | 1991-01-21 | 1994-03-03 | Shionogi Seiyaku Kabushiki Kaisha | 3-benzylidene-1-carbamoyl-2-pyrrolidone analog |
CA2365269A1 (en) | 1991-01-31 | 1992-08-20 | Warner-Lambert Company | Substituted 4,6-di-tertiary-butyl-5-hydroxy-pyrimidines |
US5177079A (en) | 1991-01-31 | 1993-01-05 | Warner-Lambert Company | 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents |
US5248682A (en) | 1991-01-31 | 1993-09-28 | Warner-Lambert Company | 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents |
US5888995A (en) | 1991-02-04 | 1999-03-30 | Astra Aktiebolag | Steroid esters |
SE9100342D0 (sv) | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroid esters |
SE9100341D0 (sv) | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
US5679640A (en) | 1991-02-12 | 1997-10-21 | Cytel Corporation | Immunosuppressant peptides |
IT1250410B (it) | 1991-02-14 | 1995-04-07 | Simes | Composti steroidei attivi sul sistema cardiovascolare |
EP0530368A4 (en) | 1991-02-28 | 1994-08-24 | Fujisawa Pharmaceutical Co | Process for producing tricyclic compound or salt thereof |
US5856364A (en) | 1991-03-01 | 1999-01-05 | Warner Lambert Company | Therapeutic antiviral-wound healing compositions and methods for preparing and using same |
US5633285A (en) | 1991-03-01 | 1997-05-27 | Warner-Lambert Company | Cytoprotective wound healing compositions and methods for preparing and using same |
US5602183A (en) | 1991-03-01 | 1997-02-11 | Warner-Lambert Company | Dermatological wound healing compositions and methods for preparing and using same |
US5863938A (en) | 1991-03-01 | 1999-01-26 | Warner Lambert Company | Antibacterial-wound healing compositions and methods for preparing and using same |
US5663208A (en) | 1991-03-01 | 1997-09-02 | Warner-Lambert Company | Antifungal wound healing compositions and methods for preparing and using same |
US5646190A (en) | 1991-03-01 | 1997-07-08 | Warner-Lambert Company | Acne treating-wound healing compositions and methods for preparing and using same |
US5652274A (en) | 1991-03-01 | 1997-07-29 | Martin; Alain | Therapeutic-wound healing compositions and methods for preparing and using same |
US5674912A (en) | 1991-03-01 | 1997-10-07 | Warner-Lambert Company | Sunscreen-wound healing compositions and methods for preparing and using same |
US5648380A (en) | 1991-03-01 | 1997-07-15 | Warner-Lambert Company | Anti-inflammatory wound healing compositions and methods for preparing and using same |
US5658957A (en) | 1991-03-01 | 1997-08-19 | Warner Lambert Company | Immunostimulating wound healing compositions and method for preparing and using same |
US5641814A (en) | 1991-03-01 | 1997-06-24 | Warner-Lambert Company | Antikeratolytic-wound healing compositions and methods for preparing and using same |
US5614561A (en) | 1991-03-01 | 1997-03-25 | Warner-Lambert Company | Antihistamine-wound healing compositions and methods for preparing and using same |
US5874479A (en) | 1991-03-01 | 1999-02-23 | Warner-Lambert Company | Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same |
CA2062370A1 (en) | 1991-03-07 | 1992-09-08 | Ryoichi Osawa | Pharmaceutical preparation |
NZ241936A (en) | 1991-03-13 | 1994-03-25 | Morinaga Milk Industry Co Ltd | Antimicrobial peptide and its use in an antimicrobial composition |
GB9107043D0 (en) | 1991-04-04 | 1991-05-22 | Pfizer Ltd | Therapeutic agents |
US5147877A (en) | 1991-04-18 | 1992-09-15 | Merck & Co. Inc. | Semi-synthetic immunosuppressive macrolides |
DE69130683T2 (de) | 1991-04-22 | 1999-05-06 | Otsuka Pharma Co Ltd | PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL |
US5091389A (en) | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
US5093338A (en) | 1991-04-23 | 1992-03-03 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
DE69223844T2 (de) | 1991-04-24 | 1998-04-16 | Morinaga Milk Industry Co Ltd | Antimikrobielles Peptid und antimikrobieller Wirkstoff |
US5223503A (en) | 1991-04-29 | 1993-06-29 | Eli Lilly And Company | 6-substituted pyrido[2,3-d]pyrimidines as antineoplastic agents |
US5183906A (en) | 1991-04-30 | 1993-02-02 | Allergan, Inc. | 2- and 5-alkyl and phenyl substituted 4-(1-hydroxy, 1-acyloxy or 1-carbamoyloxy)-5-hydroxy-2 (5h)-furanones as anti-inflammatory agents |
US5225571A (en) | 1991-04-30 | 1993-07-06 | Allergan, Inc. | Substituted dihydroxy-bis-[5-hydroxy-2(5H)-furanone-4-yl]-alkanes as anti-inflammatory agents |
US5250700A (en) | 1991-05-01 | 1993-10-05 | American Home Products Corporation | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents |
US5191084A (en) | 1991-05-01 | 1993-03-02 | American Home Products Corporation | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents |
US5138051A (en) | 1991-08-07 | 1992-08-11 | American Home Products Corporation | Rapamycin analogs as immunosuppressants and antifungals |
US5143927A (en) | 1991-05-09 | 1992-09-01 | Warner-Lambert Company | 3-(thiazolidone, oxazolidinone, imidazolidinone)-indoles as antiinflammatory agents |
US5143929A (en) | 1991-05-09 | 1992-09-01 | Warner-Lambert Company | 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents |
US5250552A (en) | 1991-05-09 | 1993-10-05 | Warner-Lambert Company | 3-[thiazolidinone, oxazolidinone, imidazolidinone]-indoles as antiinflammatory agents |
US5114958A (en) | 1991-05-09 | 1992-05-19 | Warner-Lambert Company | 1,2,4-oxadiazole and 1,2,4-thiadiazole derivatives of fenamates as antiinflammatory agents |
US5565560A (en) | 1991-05-13 | 1996-10-15 | Merck & Co., Inc. | O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
US5262533A (en) | 1991-05-13 | 1993-11-16 | Merck & Co., Inc. | Amino O-aryl macrolides having immunosuppressive activity |
US5162334A (en) | 1991-05-13 | 1992-11-10 | Merck & Co., Inc. | Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity |
US5250678A (en) | 1991-05-13 | 1993-10-05 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
IT1259419B (it) | 1991-05-24 | 1996-03-18 | Erba Carlo Spa | Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi |
US5279607A (en) | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
US5395366A (en) | 1991-05-30 | 1995-03-07 | The State University Of New York | Sampling capsule and process |
JPH06502659A (ja) | 1991-05-31 | 1994-03-24 | ファイザー インク | 免疫抑制剤としてのラパマイシンプロドラッグの使用 |
ATE164163T1 (de) | 1991-06-19 | 1998-04-15 | Upjohn Co | Dialkyl (dialkoxyphosphinyl)methyl phosphate als antientzündungsmittel |
JPH057097A (ja) | 1991-06-27 | 1993-01-14 | Tenryu Technic:Kk | チツプマウンタのチツプ部品供給装置 |
EP0526166A2 (en) | 1991-07-29 | 1993-02-03 | Albert L. Dessertine | Patient compliance monitoring method and system |
US5124347A (en) | 1991-07-31 | 1992-06-23 | Warner-Lambert Co. | 3-5-ditertiarybutylphenyl-4-hydroxymethylidene derivatives of 1,3-dihydro-2H-indole-2-ones as antiinflammatory agents |
US5149701A (en) | 1991-08-01 | 1992-09-22 | Merck & Co., Inc. | C-31 methylated FR-900520 cyclic hemiketal immunosuppressant agents |
US5273979A (en) | 1991-08-01 | 1993-12-28 | Merck & Co., Inc. | C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent |
US5169851A (en) | 1991-08-07 | 1992-12-08 | American Home Products Corporation | Rapamycin analog as immunosuppressants and antifungals |
US5202332A (en) | 1991-08-07 | 1993-04-13 | American Home Products Corporation | Rapamycin analog as immunosuppressant |
US5189042A (en) | 1991-08-22 | 1993-02-23 | Merck & Co. Inc. | Fluoromacrolides having immunosuppressive activity |
GB9118478D0 (en) | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
US5597831A (en) | 1991-08-29 | 1997-01-28 | Vufb A.S | 6-[X-(2-hydroxyethyl) aminoalkyl]-5,11-dioxo-5,6-dihydro-11-H-indeno[1,2-c]isoquinolines and their use as antineoplastic agents |
GB9118465D0 (en) | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
US5202350A (en) | 1991-08-29 | 1993-04-13 | Bristol-Myers Squibb Co. | Furanone anti-inflammatory agents |
US5171864A (en) | 1991-08-30 | 1992-12-15 | Allergan, Inc. | Di-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega alkane-dioates and N,N-bis-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents |
US5169963A (en) | 1991-08-30 | 1992-12-08 | Allergan, Inc. | Di-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega alkanedioates and N,N-bis-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents |
US5208241A (en) | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
US5270319A (en) | 1991-09-09 | 1993-12-14 | Warner-Lambert Company | 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents |
US5247076A (en) | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
US5252732A (en) | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
AU669489B2 (en) | 1991-09-18 | 1996-06-13 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
DK0605474T3 (da) | 1991-09-26 | 2004-02-23 | Us Gov Health & Human Serv | Carbamatanaloger af thiaphysovenin, farmaceutiske præparater og fremgangsmåder til inhibering af cholinesteraser |
WO1993008191A1 (en) | 1991-10-15 | 1993-04-29 | Warner-Lambert Company | Azabicyclo oxime and amine cholinergic agents and methods of treatment |
US5280045A (en) | 1991-10-16 | 1994-01-18 | The Procter & Gamble Company | 4(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamide compound useful as an anti-inflammatory agent |
US5266567A (en) | 1991-10-24 | 1993-11-30 | Rohm And Haas Company | Halopropargylated cyclic quaternary ammonium compounds as antimicrobial agents |
US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
GB9123638D0 (en) | 1991-11-07 | 1992-01-02 | Magill Alan R | Apparel & fabric & devices suitable for health monitoring applications |
US5723466A (en) | 1991-12-06 | 1998-03-03 | Hoechst Marion Roussel, Inc. | Trans cyclopentanyl purine analogs useful as immunosuppressants |
US5817672A (en) | 1991-12-06 | 1998-10-06 | Hoechst Marion Roussel, Inc. | Trans cyclopentanyl purine analogs useful as immunosuppressants |
US5817660A (en) | 1991-12-06 | 1998-10-06 | Hoechst Marion Roussel, Inc. | Trans cyclopentanyl purine analogs useful as immunosuppressants |
US5817661A (en) | 1991-12-06 | 1998-10-06 | Hoechst Marion Roussel, Inc. | Trans cyclopentanyl purine analogs useful as immunosuppressants |
US5472973A (en) | 1991-12-12 | 1995-12-05 | Scios Nova Inc. | Fluorenyl derivatives as anti-inflammatory agents |
US5338837A (en) | 1991-12-13 | 1994-08-16 | The Trustees Of Princeton University | Glycosylated steroid derivatives for transport across biological membranes and process for making same |
ZA929008B (en) | 1991-12-13 | 1993-05-21 | Bristol Myers Squibb Co | Piperazinyl- and piperidinyl-cyclohexanols. |
US5212189A (en) | 1991-12-17 | 1993-05-18 | Warner-Lambert Company | Thiadiazole or oxadiazole analogs of fenamic acids containing substituted hydroxamate side chains as antiinflammatory agents |
PL170554B1 (pl) | 1991-12-17 | 1996-12-31 | Fuisz Technologies Ltd | Sposób wytwarzania kompozycji przeciwwrzodowej PL PL PL |
US5225418A (en) | 1991-12-17 | 1993-07-06 | Du Pont Merck Pharmaceutical Company | 5H-(1,2)benzisothiazolo[2,3-a]quinoline-5-ones and analogs as antiinflammatory agents |
ZA929315B (en) | 1991-12-20 | 1993-05-24 | Akzo Nv | 17-spirofuran-3'-ylidene steroids. |
US5206415A (en) | 1991-12-20 | 1993-04-27 | Washington University | Tricyclic steroid analogs |
US5438064A (en) | 1991-12-23 | 1995-08-01 | American Home Products Corporation | Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents |
US5238689A (en) | 1992-01-07 | 1993-08-24 | Procept, Inc. | Use of ruthenium red as immunosuppressive agents |
US5176626A (en) | 1992-01-15 | 1993-01-05 | Wilson-Cook Medical, Inc. | Indwelling stent |
EP0629347B1 (en) | 1992-01-23 | 1997-07-02 | Morinaga Milk Industry Co., Ltd. | Antibacterial agent and treatment of article therewith |
US5378848A (en) | 1992-02-12 | 1995-01-03 | Shionogi & Co., Ltd. | Condensed imidazopyridine derivatives |
JP2746041B2 (ja) | 1992-02-14 | 1998-04-28 | 三菱化学株式会社 | 新規なステロイド誘導体 |
US5196431A (en) | 1992-02-24 | 1993-03-23 | Warner-Lambert Company | 2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents |
US5220025A (en) | 1992-02-24 | 1993-06-15 | Warner-Lambert Company | 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents |
JPH05228128A (ja) | 1992-02-25 | 1993-09-07 | Olympus Optical Co Ltd | 医療用カプセル |
FR2688004A1 (fr) | 1992-02-27 | 1993-09-03 | Roussel Uclaf | Nouveaux sterouides comportant en position 17 un radical methylene lactone, leur procede et des intermediaires de preparation, leur application comme medicaments. |
JPH07500613A (ja) | 1992-03-02 | 1995-01-19 | ファイザー・インコーポレーテッド | 免疫抑制剤及び抗真菌剤としてのマクロライドのデソサミノ誘導体 |
US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
EP0627940B1 (en) | 1992-03-05 | 2003-05-07 | Board of Regents, The University of Texas System | Use of immunoconjugates for the diagnosis and/or therapy of vascularized tumors |
US5157051A (en) | 1992-03-05 | 1992-10-20 | The Dow Chemical Company | Composition and use of 3-thiocyano-2-halo-2-propenenitriles as antimicrobial agents |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US5187175A (en) | 1992-03-06 | 1993-02-16 | Warner-Lambert Company | 2-carbonyl substituted-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents |
US5196424A (en) | 1992-03-24 | 1993-03-23 | Eli Lilly And Company | N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids |
US5389675A (en) | 1992-03-27 | 1995-02-14 | The United States Of America As Represented By The Department Of Health And Human Services | Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents |
US5604213A (en) | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
CA2133424A1 (en) | 1992-04-03 | 1993-10-14 | Harry Louis Platt | Sensor and system for physiological monitoring |
CA2091194A1 (en) | 1992-04-08 | 1993-10-09 | Richard D. Connell | 2-oxo-ethyl derivatives as immunosuppressants |
JP3367104B2 (ja) | 1992-04-13 | 2003-01-14 | 藤沢薬品工業株式会社 | 抗菌剤としての置換された3−ピロリジニルチオ−カルバペネム化合物 |
US5698720A (en) | 1992-04-20 | 1997-12-16 | Sankyo Company, Limited | Steroid derivatives |
ATE154937T1 (de) | 1992-04-20 | 1997-07-15 | Sankyo Co | Steroide zur behandlung von prostatisch- hypertrophe, ihre herstellung und verwendung |
US5256664A (en) | 1992-04-28 | 1993-10-26 | Bristol-Myers Squibb Company | Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones |
US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
US5552397A (en) | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
GB9210880D0 (en) | 1992-05-21 | 1992-07-08 | Smithkline Beecham Corp | Compounds |
US5263481A (en) | 1992-05-21 | 1993-11-23 | Jens Axelgaard | Electrode system with disposable gel |
US5346913A (en) | 1992-05-26 | 1994-09-13 | Rohm And Haas Company | N-iodopropargyl hydantoin compounds, compositions, preparation, and use as antimicrobial agents |
US5244917A (en) | 1992-06-02 | 1993-09-14 | The Dupont Merck Pharmaceutical Company | Substituted naphthofurans as anti-inflammatory agents |
US5283136A (en) | 1992-06-03 | 1994-02-01 | Ramot University Authority For Applied Research And Industrial Development Ltd. | Rechargeable batteries |
FR2691968B1 (fr) | 1992-06-04 | 1994-07-29 | Roussel Uclaf | Nouveau procede de preparation d'un derive sterouide 11-ceto. |
HU212308B (en) | 1992-06-09 | 1996-05-28 | Richter Gedeon Vegyeszet | Process for producing novel pregnane steroids and pharmaceutical compositions containing the same |
US5284877A (en) | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkyl and alkenyl macrolides having immunosuppressive activity |
US5284840A (en) | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkylidene macrolides having immunosuppressive activity |
CA2138542A1 (en) | 1992-06-23 | 1994-01-06 | Masaaki Ishizuka | New antibiotics having immunosuppressive activity, delaminomycins and processes for the production of the same |
WO1994000478A1 (en) | 1992-06-26 | 1994-01-06 | Pfizer Inc. | Steroidal beta-o-cellobioside heptaalkanoate process |
US5338753A (en) | 1992-07-14 | 1994-08-16 | Sumner H. Burstein | (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics |
US5261402A (en) | 1992-07-20 | 1993-11-16 | Graphic Controls Corporation | Snapless, tabless, disposable medical electrode with low profile |
US5338625A (en) | 1992-07-29 | 1994-08-16 | Martin Marietta Energy Systems, Inc. | Thin film battery and method for making same |
CA2100514C (en) | 1992-07-29 | 2005-03-29 | Johannes A. M. Hamersma | 17-spiromethylene steroids |
DK0654041T3 (da) | 1992-07-31 | 1998-10-26 | Pfizer | Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyre-derivater som anto-inflammatoriske midler |
US5240929A (en) | 1992-08-03 | 1993-08-31 | Warner-Lambert Company | 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents |
US7758503B2 (en) | 1997-01-27 | 2010-07-20 | Lynn Lawrence A | Microprocessor system for the analysis of physiologic and financial datasets |
US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
WO1994007501A1 (en) | 1992-09-23 | 1994-04-14 | The Upjohn Company | Arylmethylphosphonates and phosphonic acids useful as anti-inflammatory agents |
US5288564A (en) | 1992-09-30 | 1994-02-22 | Magnavox Electronic Systems Company | Compact, cylindrical, multi-cell seawater battery |
US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US5721099A (en) | 1992-10-01 | 1998-02-24 | Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
JP2711202B2 (ja) | 1992-10-06 | 1998-02-10 | 東洋製薬株式会社 | ブドウ球菌抗菌剤 |
DE69329792T2 (de) | 1992-10-08 | 2001-05-31 | Supratek Pharma Inc | Zusammensetzung von in mizellen eingeschlossenen antineoplastischen wirkstoffen |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
EP0627406B1 (en) | 1992-10-21 | 1998-10-28 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1,3-propanediol compound and immunosuppressant |
US5843452A (en) | 1992-11-09 | 1998-12-01 | Pharmagenesis, Inc. | Immunotherapy composition and method |
ES2058024B1 (es) | 1992-11-10 | 1995-05-01 | Menarini Lab | Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. |
US5561124A (en) | 1992-11-18 | 1996-10-01 | Webb; Robert L. | 17-α-acyl steroids which inhibit 5-α-reductase |
US5260300A (en) | 1992-11-19 | 1993-11-09 | American Home Products Corporation | Rapamycin carbonate esters as immuno-suppressant agents |
JP2738486B2 (ja) | 1992-11-20 | 1998-04-08 | ファイザー製薬株式会社 | 抗炎症剤としての新規なイソオキサゾリン類 |
EP0671882B1 (en) | 1992-12-01 | 1998-07-22 | Minnesota Mining And Manufacturing Company | Durable anti-microbial agents |
DK148292D0 (da) | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Forbindelser |
FR2699176B1 (fr) | 1992-12-11 | 1995-03-03 | Adir | Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant. |
IL108031A0 (en) | 1992-12-22 | 1994-04-12 | Procter & Gamble | Difluoro pentapeptide derivatives and pharmaceutical compositions containing them |
GB9226830D0 (en) | 1992-12-23 | 1993-02-17 | Celltech Ltd | Chemical compounds |
US5693645A (en) | 1992-12-23 | 1997-12-02 | Beth Israel Deaconess Medical Center, Inc. | Use of spiperone or spiperone derivatives as immunosuppressant agents |
US5506221A (en) | 1992-12-24 | 1996-04-09 | University Of British Columbia | Contignasterol, and related 3-alpha hydroxy-6-alpha hydroxy-7-beta hydroxy-15-keto-14-beta steroids useful as anti-inflammatory and anti-thrombosis agents |
FR2700339B1 (fr) | 1993-01-14 | 1995-03-03 | Roussel Uclaf | Nouveaux dérivés 17,20-époxydes du pregnane, leur préparation, leur application à la préparation de dérivés cortisoniques et intermédiaires. |
US5298522A (en) | 1993-01-22 | 1994-03-29 | Pfizer Inc. | 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio |
EP0608568B1 (en) | 1993-01-29 | 1998-03-11 | American Cyanamid Company | Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents |
US5424301A (en) | 1993-02-01 | 1995-06-13 | Warner-Lambert Company | Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents |
US5710144A (en) | 1993-02-08 | 1998-01-20 | Akzo Nobel N.V. | C-11 substituted steroids for treating menopausal complaints |
DK0610744T3 (da) | 1993-02-09 | 1999-07-19 | Bayer Ag | Sulfonamidaminomethylenderivater som immunosuppressive stoffer |
US5686469A (en) | 1993-02-09 | 1997-11-11 | Miles Inc. | Aminomethylene derivaties as immunosuppressants |
CA2155664C (en) | 1993-02-09 | 1999-06-15 | Ralph P. Robinson | Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as antiinflammatory agents |
US5385918A (en) | 1993-02-09 | 1995-01-31 | Miles Inc. | Aminomethylene-peptides as immunosuppressants |
JP3525221B2 (ja) | 1993-02-17 | 2004-05-10 | 味の素株式会社 | 免疫抑制剤 |
US5463181A (en) | 1993-02-23 | 1995-10-31 | Merrell Dow Pharmaceuticals Inc. | Farnesyl: protein transferase inhibitors as anticancer agents |
CA2090171A1 (en) | 1993-02-23 | 1994-08-24 | Peter W. Schiller | Opioid receptor antagonists, their synthesis and use as analgesic and immunosuppressive compounds |
WO1994019357A1 (en) | 1993-02-23 | 1994-09-01 | Merrell Dow Pharmaceuticals Inc. | Farnesyl:protein transferase inhibitors as anticancer agents |
US5914132A (en) * | 1993-02-26 | 1999-06-22 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
US5292736A (en) | 1993-02-26 | 1994-03-08 | Sterling Winthrop Inc. | Morpholinoalkylindenes as antiglaucoma agents |
CA2116621C (en) | 1993-03-03 | 2001-07-24 | Rene C. Gaudreault | Novel anticancer agents |
US5391544A (en) | 1993-03-04 | 1995-02-21 | Kagome Kabushiki Kaisha | Cyathane derivatives and antimicrobial agents containing same |
FR2702214B1 (fr) | 1993-03-05 | 1995-04-14 | Adir | Nouveaux composés (aryl(alkyl)carbonyl)-hétérocycliques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
WO1994020520A1 (en) | 1993-03-10 | 1994-09-15 | Magainin Pharmaceuticals Inc. | Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants |
US5484788A (en) | 1993-03-26 | 1996-01-16 | Beth Israel Hospital Association | Buspirone as a systemic immunosuppressant |
US5757326A (en) | 1993-03-29 | 1998-05-26 | Seiko Epson Corporation | Slot antenna device and wireless apparatus employing the antenna device |
EP0618182B1 (en) | 1993-03-31 | 1996-12-18 | Kagome Kabushiki Kaisha | Indene derivatives and antimicrobial agents containing them |
JPH06298611A (ja) | 1993-04-16 | 1994-10-25 | Nippon Chemiphar Co Ltd | 抗菌剤 |
US5459151A (en) | 1993-04-30 | 1995-10-17 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents |
FR2704969B1 (fr) | 1993-05-06 | 1995-07-28 | Centre Scient Tech Batiment | Dispositif d'atténuation acoustique à double paroi active. |
US5393771A (en) | 1993-05-12 | 1995-02-28 | Brisol-Myers Squibb Company | 4-substituted benzopyran and related compounds |
US5654294A (en) | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
US5380738A (en) | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
US5406945A (en) | 1993-05-24 | 1995-04-18 | Ndm Acquisition Corp. | Biomedical electrode having a secured one-piece conductive terminal |
KR100325562B1 (ko) | 1993-05-24 | 2002-07-22 | 그루포 레페티트 에스. 피. 에이. | 리파마이신의36-유도체및항미생물제로서의그의용도 |
FR2706454B1 (fr) | 1993-06-17 | 1995-09-15 | Roussel Uclaf | Nouveaux 19-Nor stéroïdes, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les contenant. |
US5440016A (en) | 1993-06-18 | 1995-08-08 | Torrey Pines Institute For Molecular Studies | Peptides of the formula (KFmoc) ZZZ and their uses |
AU676293B2 (en) | 1993-06-24 | 1997-03-06 | Wilson Greatbatch Ltd. | Electrode covering for electrochemical cells |
US5436265A (en) | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
US5288693A (en) | 1993-06-25 | 1994-02-22 | Rohm And Haas Company | 2-(3-oxoalk(en)yl)-3-isothiazolones and derivatives as antimicrobial agents |
DE4321306A1 (de) | 1993-06-26 | 1995-01-05 | Sanol Arznei Schwarz Gmbh | Disulfide |
WO1995001175A1 (en) | 1993-07-02 | 1995-01-12 | The University Of Nottingham | Immunosuppressant and antiallergic compounds, e.g. n-(3-oxohexanoyl) homoserine lactone |
US5394882A (en) | 1993-07-21 | 1995-03-07 | Respironics, Inc. | Physiological monitoring system |
US5494895A (en) | 1993-07-22 | 1996-02-27 | Merck & Co., Inc. | Scorpion peptide margatoxin with immunosuppressant activity |
JPH0741484A (ja) | 1993-07-29 | 1995-02-10 | Katayama Seiyakushiyo:Kk | セフェム化合物及び抗菌剤 |
US5506248A (en) | 1993-08-02 | 1996-04-09 | Bristol-Myers Squibb Company | Pharmaceutical compositions having good dissolution properties |
CA2166332C (en) | 1993-08-04 | 2005-05-10 | Bernardus Wynand Machijs Marie Peeters | Antiglucocorticoid steroids for the treatment of anxiety disorders |
US5458141A (en) | 1993-08-04 | 1995-10-17 | Quinton Instrument Company | Abrasive skin electrode |
US5731322A (en) | 1993-08-06 | 1998-03-24 | Smithkline Beecham S.P.A. | Octahydro-1H-pyrrolo 3,2-g!and 2,3-g!isoquinoline derivatives |
JP3193205B2 (ja) | 1993-08-09 | 2001-07-30 | 日本臓器製薬株式会社 | 好酸球増多抑制剤 |
WO1995005830A1 (en) | 1993-08-20 | 1995-03-02 | The Regents Of The University Of California | Polyanion anti-inflammatory agents |
US5443461A (en) | 1993-08-31 | 1995-08-22 | Alza Corporation | Segmented device for simultaneous delivery of multiple beneficial agents |
US5385902A (en) | 1993-09-01 | 1995-01-31 | Rohm And Haas Company | Iodopropargylated oxalic derivatives as antimicrobial agents |
DE4329898A1 (de) | 1993-09-04 | 1995-04-06 | Marcus Dr Besson | Kabelloses medizinisches Diagnose- und Überwachungsgerät |
US5512678A (en) | 1993-09-14 | 1996-04-30 | Merrell Pharmaceuticals Inc. | 5-(1-fluoro-vinyl)-1H-pyrimidine-2,4-dione derivatives useful as antineoplastic agents |
NZ273433A (en) | 1993-09-24 | 1997-11-24 | Merrell Pharma Inc | 1,2-diphenyl-2-chloro(or bromo)-1-(4-amino(or azacyclic)alkyloxy(or amino)phenyl)ethylene derivatives; pharmaceutical compositions |
US5525633A (en) | 1993-09-24 | 1996-06-11 | Merrell Dow Pharmaceuticals Inc. | Triaryl-ethylene derivatives |
US5470885A (en) | 1993-09-29 | 1995-11-28 | The Research Foundation Of The State University Of New York | Fluorocarbons as anti-inflammatory agents |
US5547966A (en) | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
US5837702A (en) | 1993-10-07 | 1998-11-17 | Bristol-Myers Squibb Co. | 4-arylamino-benzopyran and related compounds |
US5401758A (en) | 1993-10-07 | 1995-03-28 | Bristol-Myers Squibb Company | Pyridinyl cyanoguanidine compounds |
EP0841965B1 (en) | 1994-03-21 | 2002-04-10 | Dusa Pharmaceuticals, Inc. | Patch and controller for the photodynamic therapy of a dermal lesion |
US5580892A (en) | 1993-10-22 | 1996-12-03 | Allergan | Method for using 2-(2-alkylphenylamino)-oxazolines as adrenergic agents |
US5677293A (en) | 1993-10-27 | 1997-10-14 | Merrell Pharmaceuticals Inc. | 16 unsaturated C17 heterocyclic steroids useful as steroid C17-20 lyase inhibitors |
US5554373A (en) | 1993-11-05 | 1996-09-10 | Seabrook; Samuel G. | Compositions containing anti-microbial agents and methods for making and using same |
US5541230A (en) | 1993-11-05 | 1996-07-30 | Us Health | Therapeutic polyamines |
JPH09505597A (ja) | 1993-11-22 | 1997-06-03 | メルク エンド カンパニー インコーポレーテッド | 3−アシルアミノベンゾアゼピン類 |
CA2176020A1 (en) | 1993-11-22 | 1995-06-01 | John J. Baldwin | Benzodiazepines |
ATE154932T1 (de) | 1993-11-26 | 1997-07-15 | Pfizer | Isoxazolinverbindungen als entzündungshemmende mittel |
EP0730587B1 (en) | 1993-11-26 | 1999-12-08 | Pfizer Inc. | 3-phenyl-2-isoxazolines as antiinflammatory agents |
US6390088B1 (en) * | 1993-12-13 | 2002-05-21 | Boehringer Ingelheim Kg | Aerosol inhaler |
DK0735047T3 (da) | 1993-12-15 | 1999-07-26 | Taisho Pharmaceutical Co Ltd | Sterolepoxider til cancerbehandling |
US5462950A (en) | 1993-12-21 | 1995-10-31 | Eli Lilly And Company | Methods of treating menstrual symptoms and compositions therefore |
CA2136803A1 (en) | 1993-12-22 | 1995-06-23 | Kazumi Ogata | Steroid derivatives |
US5646136A (en) | 1994-01-04 | 1997-07-08 | Duke University | Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids |
US5631283A (en) | 1994-02-02 | 1997-05-20 | The United States Of America As Represented By The Secretary Of The Army | Use of sialic acid or antibodies to sialidase as anti-infectious agents and anti-inflammatory agents |
US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
US5444043A (en) | 1994-02-18 | 1995-08-22 | The Regents Of The University Of California | Cyclic heptapeptide anti-inflammatory agent |
US5508417A (en) | 1994-02-23 | 1996-04-16 | Rohm And Haas Company | Broad-spectrum isothiazole antimicrobial agents |
US5659247A (en) | 1994-03-10 | 1997-08-19 | Denver Dynamics, Inc. | Device for detecting metal objects passing through an opening |
US5482925A (en) | 1994-03-17 | 1996-01-09 | Comedicus Incorporated | Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents |
EP0673881B1 (en) | 1994-03-25 | 1999-06-16 | Kabushiki Kaisha Kaisui Kagaku Kenkyujo | Antimicrobial agent |
US5551020A (en) | 1994-03-28 | 1996-08-27 | Flextech Systems, Inc. | System for the compacting and logical linking of data blocks in files to optimize available physical storage |
US5451686A (en) | 1994-04-15 | 1995-09-19 | Allergan, Inc. | 3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents |
CA2187429A1 (en) | 1994-04-28 | 1995-11-09 | Junya Ohmori | N-(3-pyrrolidinyl)benzamide derivative |
DE69507139T2 (de) | 1994-05-02 | 1999-09-30 | Merrell Pharma Inc | Verfahren zur herstellung von 4-amino-delta 4-3-ketosteroiden via 4-nitro-delta-4-3-ketosteroiden |
US5683709A (en) | 1994-05-05 | 1997-11-04 | Ciba Vision Corporation | Poly(benzalkonium salt) as an anti-microbial agent for aqueous drug compositions |
US5688997A (en) | 1994-05-06 | 1997-11-18 | Pharmacopeia, Inc. | Process for preparing intermediates for a combinatorial dihydrobenzopyran library |
JP3179286B2 (ja) | 1994-05-19 | 2001-06-25 | ファイザー製薬株式会社 | N−ヒドロキシ尿素系抗炎症剤 |
US5476876A (en) | 1994-05-24 | 1995-12-19 | The Procter & Gamble Company | Di-tert-butylphenol compounds useful as anti-inflammatory agents |
US5880280A (en) | 1994-06-15 | 1999-03-09 | Merck & Co., Inc. | Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity |
US5550233A (en) | 1994-06-21 | 1996-08-27 | Merck & Co., Inc. | Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity |
US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
FR2721610B1 (fr) | 1994-06-28 | 1996-08-23 | Adir | Nouveaux dérivés (thia)cycloalkyl [b] indoles, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
FR2721927B1 (fr) | 1994-07-01 | 1996-08-09 | Roussel Uclaf | Nouveau procede de preparation de derives steroides 20-oxo 17 alpha, 21-dihydroxyles et nouveaux intermediaires |
US5786344A (en) | 1994-07-05 | 1998-07-28 | Arch Development Corporation | Camptothecin drug combinations and methods with reduced side effects |
US5656661A (en) | 1994-07-27 | 1997-08-12 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
US5525606A (en) | 1994-08-01 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
US5792757A (en) | 1994-08-04 | 1998-08-11 | Pherin Pharmaceuticals | 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function |
US5563131A (en) | 1994-08-04 | 1996-10-08 | Pherin Corporation | Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
JPH0853424A (ja) | 1994-08-11 | 1996-02-27 | Kureha Chem Ind Co Ltd | ベンズイミダゾールスルホン酸アミド誘導体 |
US5600548A (en) | 1994-08-11 | 1997-02-04 | Sundstrand Corporation | DC content control for an inverter |
US5461070A (en) | 1994-08-29 | 1995-10-24 | The Regents Of The University Of California | Anti-flammatory method using indole alkaloids |
DE9414065U1 (de) * | 1994-08-31 | 1994-11-03 | Roehm Gmbh | Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen |
US5684002A (en) | 1994-09-07 | 1997-11-04 | The Procter & Gamble Company | Dihydorbenzofuran and related compounds useful as anti-inflammatory agents |
US5463564A (en) | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
US5693648A (en) | 1994-09-30 | 1997-12-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity |
US5554645A (en) | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
ATE205391T1 (de) | 1994-10-05 | 2001-09-15 | Helsinn Healthcare Sa | Nimesulid zur aüsserlichen anwendung |
JP3121503B2 (ja) | 1994-10-18 | 2001-01-09 | レンゴー株式会社 | 抗菌剤 |
US5510361A (en) | 1994-10-20 | 1996-04-23 | The Procter & Gamble Company | Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents |
US5545734A (en) | 1994-10-25 | 1996-08-13 | Merck & Co., Inc. | Aryl and heteroaryl macrolides having immunosuppressive activity |
IL111396A (en) | 1994-10-25 | 1997-07-13 | Ness Neuromuscular Electrical Stimulation Systems Ltd | Electrode system |
IL115659A (en) | 1994-10-27 | 2000-06-01 | Akzo Nobel Nv | Steroids with a 17-spiromethylene lactone or lactol group process for their preparation and pharmaceutical compositions containing them |
US5512687A (en) | 1994-10-28 | 1996-04-30 | Procept, Inc. | Compounds for inhibiting immune response |
US5622948A (en) | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
US5688696A (en) | 1994-12-12 | 1997-11-18 | Selectide Corporation | Combinatorial libraries having a predetermined frequency of each species of test compound |
US5718098A (en) | 1994-12-30 | 1998-02-17 | Pharmagraphics L.L.C., Midwest | Method for producing sample package |
US5552422A (en) | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
US5648376A (en) | 1995-01-19 | 1997-07-15 | Pharmagenesis, Inc. | Immunosuppressant diterpene compound |
EP0754460B1 (en) | 1995-02-07 | 2002-06-05 | Shiseido Company Limited | Antiinflammatory agents |
US5485841A (en) | 1995-02-14 | 1996-01-23 | Univ Mcgill | Ultrasonic lung tissue assessment |
US5670504A (en) | 1995-02-23 | 1997-09-23 | Merck & Co. Inc. | 2,6-diaryl pyridazinones with immunosuppressant activity |
US5506228A (en) | 1995-02-23 | 1996-04-09 | Merck & Co., Inc. | 2,6-diaryl pyridazinones with immunosuppressant activity |
US5778882A (en) | 1995-02-24 | 1998-07-14 | Brigham And Women's Hospital | Health monitoring system |
US6374670B1 (en) | 1995-03-13 | 2002-04-23 | University Of Washington | Non-invasive gut motility monitor |
US5604262A (en) | 1995-03-22 | 1997-02-18 | Research Corporation Technologies, Inc. | Topical antimicrobial agents |
US5661141A (en) | 1995-03-27 | 1997-08-26 | Petrow; Vladimir | 19-oxygenated steroids as therapeutic agents |
US5845265A (en) | 1995-04-26 | 1998-12-01 | Mercexchange, L.L.C. | Consignment nodes |
JP4074661B2 (ja) | 1995-05-08 | 2008-04-09 | マサチューセッツ・インスティテュート・オブ・テクノロジー | 信号伝送媒体として人体を用いた非接触検知及び信号システム |
IT1282286B1 (it) | 1995-05-11 | 1998-03-16 | Sigma Tau Ind Farmaceuti | Seco-d steroidi sul sistema cardiovascolare, processi per la loro preparazione e composizioni farmaceutiche che li contengono. |
CA2176412C (en) | 1995-05-18 | 2008-10-07 | David Henry Wilson | Rotary tabletting press |
US5552411A (en) | 1995-05-26 | 1996-09-03 | Warner-Lambert Company | Sulfonylquinolines as central nervous system and cardiovascular agents |
US5618813A (en) | 1995-05-26 | 1997-04-08 | Abbott Laboratories | Benzo[5.6]pyrano[2.3.4-ij]quinolizine and benzo[5.6]thiopyrano[2.3.4-ij]quinolizine derivatives as antibacterial and antineoplastic agents |
US5643950A (en) | 1995-06-02 | 1997-07-01 | Ortho Pharmaceutical Corporation | Triphenylalkyl antimicrobial agents |
US5753715A (en) | 1995-06-02 | 1998-05-19 | Ortho Pharmaceutical Corporation | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents |
US5645063A (en) | 1995-06-05 | 1997-07-08 | Quinton Instrument Company | Skin electrode having multiple conductive center members |
US5726171A (en) | 1995-06-07 | 1998-03-10 | Merck & Co Inc | N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides |
US5738708A (en) * | 1995-06-07 | 1998-04-14 | The Regents Of The University Of California Office Of Technology Transfer | Composite metal membrane |
US5612323A (en) | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phosphinic ester substituted benzopyran derivatives |
AU720378B2 (en) | 1995-06-07 | 2000-06-01 | Merck & Co., Inc. | Novel N-(4-oxo-2,3,4,5-tetrahydro-1H-1, 5-benzodiazepin-3yl)-3-amides |
US5612370A (en) | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phenylglycine and phenylalaninen amido benzopyran derivatives |
US5869478A (en) | 1995-06-07 | 1999-02-09 | Bristol-Myers Squibb Company | Sulfonamido substituted benzopyran derivatives |
US5631251A (en) | 1995-06-07 | 1997-05-20 | Merck & Co., Inc. | 5-cyclopropyl-1,4 benzodiazepine-2-ones |
US5603363A (en) | 1995-06-20 | 1997-02-18 | Exel Nelson Engineering Llc | Apparatus for dispensing a carbonated beverage with minimal foaming |
JPH11509086A (ja) | 1995-06-21 | 1999-08-17 | マーテック・バイオサイエンシズ・コーポレイション | 標識生化学化合物の組合わせライブラリーとその作成方法 |
US6083248A (en) * | 1995-06-23 | 2000-07-04 | Medtronic, Inc. | World wide patient location and data telemetry system for implantable medical devices |
US5720771A (en) | 1995-08-02 | 1998-02-24 | Pacesetter, Inc. | Method and apparatus for monitoring physiological data from an implantable medical device |
US5686488A (en) | 1995-08-25 | 1997-11-11 | Alcon Laboratories, Inc. | Polyethoxylated castor oil products as anti-inflammatory agents |
US5776946A (en) | 1995-08-28 | 1998-07-07 | Mcgeer; Patrick L. | Peripheral benzodiazepine receptor ligands as antiinflammatory agents |
US5772575A (en) | 1995-09-22 | 1998-06-30 | S. George Lesinski | Implantable hearing aid |
US5802467A (en) | 1995-09-28 | 1998-09-01 | Innovative Intelcom Industries | Wireless and wired communications, command, control and sensing system for sound and/or data transmission and reception |
BR9610948A (pt) | 1995-10-11 | 1999-01-12 | Motorola Inc | Etiqueta eletrônica acionada à distância e excitador/leitor associado e processo correlato |
JPH09110877A (ja) | 1995-10-17 | 1997-04-28 | Katayama Seiyakushiyo:Kk | セフェム化合物、その製造法及びそれを含有する抗菌剤 |
US6076016A (en) | 1995-10-19 | 2000-06-13 | Feierbach; Gary F. | Galvanic transdermal conduction communication system and method |
US5763361A (en) | 1995-10-23 | 1998-06-09 | Merck & Co., Inc. | 17-alkyl-7-substituted-4-aza steroid derivatives as 5-α-reductase inhibitors |
US5679705A (en) | 1995-10-31 | 1997-10-21 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US5883119A (en) | 1995-10-31 | 1999-03-16 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US5696156A (en) | 1995-10-31 | 1997-12-09 | Merck & Co. Inc. | Triterpene derivatives with immunosuppressant activity |
US5696117A (en) | 1995-11-07 | 1997-12-09 | Ortho Pharmaceutical Corporation | Benzoxazine antimicrobial agents |
GB9522872D0 (en) | 1995-11-08 | 1996-01-10 | Oxford Medical Ltd | Improvements relating to physiological monitoring |
US5684204A (en) | 1995-11-15 | 1997-11-04 | The Procter & Gamble Company | Sulfur containing di-tert-butylphenol compounds useful as anti-inflammatory agents |
US8092224B2 (en) | 1995-11-22 | 2012-01-10 | James A. Jorasch | Systems and methods for improved health care compliance |
SE9504258D0 (sv) | 1995-11-28 | 1995-11-28 | Pacesetter Ab | Device and method for generating a synthesized ECG |
US5792758A (en) | 1995-12-08 | 1998-08-11 | G. D. Searle & Co. | Steroid nitrite ester derivatives useful as anti-inflammatory drugs |
US5707984A (en) | 1995-12-08 | 1998-01-13 | G. D. Searle & Co. | Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs |
DE19547648A1 (de) | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
US5596302A (en) | 1996-01-17 | 1997-01-21 | Lucent Technologies Inc. | Ring oscillator using even numbers of differential stages with current mirrors |
US5707990A (en) | 1996-01-30 | 1998-01-13 | Ortho Pharmaceutical Corporation | 2-substituted amino and thio alkyl benzoxazine antimicrobial agents |
US5618835A (en) | 1996-02-01 | 1997-04-08 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
US5672620A (en) | 1996-02-01 | 1997-09-30 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
US5750543A (en) | 1996-02-01 | 1998-05-12 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
US5821250A (en) | 1996-02-01 | 1998-10-13 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
US5684041A (en) | 1996-02-01 | 1997-11-04 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
US5684031A (en) | 1996-02-01 | 1997-11-04 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
US5686471A (en) | 1996-02-01 | 1997-11-11 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
KR19990082641A (ko) | 1996-02-15 | 1999-11-25 | 알만드 피. 뉴커만스 | 개량된 생체교합적인 트랜스듀서 |
US5868136A (en) | 1996-02-20 | 1999-02-09 | Axelgaard Manufacturing Co. Ltd. | Medical electrode |
US20010044588A1 (en) | 1996-02-22 | 2001-11-22 | Mault James R. | Monitoring system |
US5859027A (en) | 1996-02-26 | 1999-01-12 | Chektec Corporation | Antimicrobial agent |
US5833603A (en) | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
US5731423A (en) | 1996-03-21 | 1998-03-24 | Transcell Technologies, Inc. | Process for preparing sulfoxides |
WO1997036646A1 (fr) | 1996-04-01 | 1997-10-09 | Valery Ivanovich Kobozev | Stimulateur electrique des voies gastro-intestinales |
GB9608268D0 (en) | 1996-04-22 | 1996-06-26 | Robertson James L | Blister pack |
US5864578A (en) | 1996-04-29 | 1999-01-26 | Golden Bridge Technology, Inc. | Matched filter-based handoff method and apparatus |
JP3740212B2 (ja) * | 1996-05-01 | 2006-02-01 | 株式会社ルネサステクノロジ | 不揮発性半導体記憶装置 |
US5837698A (en) | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
FR2749012B1 (fr) | 1996-05-22 | 1998-08-07 | Hoechst Marion Roussel Inc | Nouveaux steroides 1 ou 6-hydroxyles, leur procede de preparation, leur application a titre de medicament et les compositions pharmaceutiques les renfermant |
US5688825A (en) | 1996-05-31 | 1997-11-18 | University Of Connecticut | Anandamide amidase inhibitors as analgesic agents |
US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
US5741798A (en) | 1996-06-03 | 1998-04-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | 2-benzyl-4-sulfonyl-4H-isoquinolin-1,3-diones and their use as antiinflammatory agents |
US5800421A (en) | 1996-06-12 | 1998-09-01 | Lemelson; Jerome H. | Medical devices using electrosensitive gels |
US5773469A (en) | 1996-06-18 | 1998-06-30 | Ortho Pharmaceutical Corporation | Diaryl antimicrobial agents |
JP3636826B2 (ja) | 1996-07-01 | 2005-04-06 | 積水化学工業株式会社 | 生体電気インピーダンス測定装置 |
US6535929B1 (en) | 1996-07-02 | 2003-03-18 | Sun Microsystems, Inc. | Universal communication mechanism for applications running in a multitasking environment |
US5677318A (en) | 1996-07-11 | 1997-10-14 | Merck Frosst Canada, Inc. | Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents |
US5877184A (en) | 1996-08-06 | 1999-03-02 | Merck & Co., Inc. | Macrolides having immunosuppressive activity |
EP0877600B1 (en) | 1996-08-09 | 2003-10-22 | Alcon Manufacturing Ltd. | Preservative systems for pharmaceutical compositions containing cyclodextrins |
US5874476A (en) | 1997-07-14 | 1999-02-23 | Rohm And Haas Company | Dihaloformaldoxime carbamates as antimicrobial agents |
WO1998007364A1 (de) | 1996-08-16 | 1998-02-26 | Roche Diagnostics Gmbh | Kontrollsystem für die überwachung der regelmässigen einnahme eines medikamentes |
SI0938318T1 (en) | 1996-08-29 | 2001-12-31 | Sanofi Synthelabo | Tablet with controlled release of alfuzosine chlorydrate |
US5884031A (en) | 1996-10-01 | 1999-03-16 | Pipe Dream, Inc. | Method for connecting client systems into a broadcast network |
US5963132A (en) | 1996-10-11 | 1999-10-05 | Avid Indentification Systems, Inc. | Encapsulated implantable transponder |
US5763478A (en) | 1996-10-16 | 1998-06-09 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US5874594A (en) | 1996-10-16 | 1999-02-23 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
GB9623634D0 (en) | 1996-11-13 | 1997-01-08 | Bpsi Holdings Inc | Method and apparatus for the coating of substrates for pharmaceutical use |
US6364834B1 (en) | 1996-11-13 | 2002-04-02 | Criticare Systems, Inc. | Method and system for remotely monitoring multiple medical parameters in an integrated medical monitoring system |
US5796827A (en) * | 1996-11-14 | 1998-08-18 | International Business Machines Corporation | System and method for near-field human-body coupling for encrypted communication with identification cards |
US8734339B2 (en) | 1996-12-16 | 2014-05-27 | Ip Holdings, Inc. | Electronic skin patch for real time monitoring of cardiac activity and personal health management |
US5928142A (en) | 1996-12-17 | 1999-07-27 | Ndm, Inc. | Biomedical electrode having a disposable electrode and a reusable leadwire adapter that interfaces with a standard leadwire connector |
US5684042A (en) | 1997-01-10 | 1997-11-04 | Medlogic Global Corporation | Cyanoacrylate compositions comprising an antimicrobial agent |
US6122351A (en) | 1997-01-21 | 2000-09-19 | Med Graph, Inc. | Method and system aiding medical diagnosis and treatment |
US5974124A (en) | 1997-01-21 | 1999-10-26 | Med Graph | Method and system aiding medical diagnosis and treatment |
US5763432A (en) | 1997-01-29 | 1998-06-09 | Sri International | Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use |
US6317714B1 (en) | 1997-02-04 | 2001-11-13 | Microsoft Corporation | Controller and associated mechanical characters operable for continuously performing received control data while engaging in bidirectional communications over a single communications channel |
US5703463A (en) | 1997-02-18 | 1997-12-30 | National Semiconductor Corporation | Methods and apparatus for protecting battery cells from overcharge |
WO1998041279A1 (en) | 1997-03-17 | 1998-09-24 | Nims, Inc. | Physiologic signs feedback system |
US5855907A (en) | 1997-03-24 | 1999-01-05 | Peyman; Gholam A. | Method of treatment of migraine |
EP0973437A4 (en) | 1997-03-31 | 2001-03-07 | Telecom Medical Inc | PATIENT CONTROL DEVICE |
US5801193A (en) | 1997-04-15 | 1998-09-01 | Immune Modulation, Inc. | Compositions and methods for immunosuppressing |
US5981166A (en) * | 1997-04-23 | 1999-11-09 | Pharmaseq, Inc. | Screening of soluble chemical compounds for their pharmacological properties utilizing transponders |
DE19717023C2 (de) | 1997-04-23 | 2003-02-06 | Micronas Gmbh | Vorrichtung zum Behandeln von malignen, tumorösen Gewebebereichen |
US5866558A (en) | 1997-05-08 | 1999-02-02 | Regents Of The University Of Minnesota | 6-alkynyl steroids |
US6288629B1 (en) | 1997-05-23 | 2001-09-11 | Intermec Ip Corp. | Method of using write—ok flag for radio frequency (RF) transponders (RF Tags) |
US5921925A (en) | 1997-05-30 | 1999-07-13 | Ndm, Inc. | Biomedical electrode having a disposable electrode and a reusable leadwire adapter that interfaces with a standard leadwire connector |
US6018229A (en) | 1997-06-30 | 2000-01-25 | Compaq Computer Corporation | Lithium-ion battery pack with integral switching regulator using cutoff transistor |
US5880115A (en) | 1997-07-18 | 1999-03-09 | Duquesne University Of The Holy Ghost | Steroid sulfatase inhibitors and methods for making and using the same |
GB2327591A (en) * | 1997-07-24 | 1999-02-03 | Nestle Sa | Reduced fat chocolate |
US5984875A (en) | 1997-08-22 | 1999-11-16 | Innotek Pet Products, Inc. | Ingestible animal temperature sensor |
US5862808A (en) * | 1997-08-26 | 1999-01-26 | Cigar Savor Enterprises Llc | Cigar punch |
US6409674B1 (en) | 1998-09-24 | 2002-06-25 | Data Sciences International, Inc. | Implantable sensor with wireless communication |
JPH11195415A (ja) | 1997-11-05 | 1999-07-21 | Matsushita Electric Ind Co Ltd | 非水電解質電池とその製造法 |
US6211799B1 (en) * | 1997-11-06 | 2001-04-03 | Massachusetts Institute Of Technology | Method and apparatus for transbody transmission of power and information |
US7035818B1 (en) | 1997-11-21 | 2006-04-25 | Symbol Technologies, Inc. | System and method for electronic inventory |
US5948227A (en) | 1997-12-17 | 1999-09-07 | Caliper Technologies Corp. | Methods and systems for performing electrophoretic molecular separations |
GB9801363D0 (en) | 1998-01-22 | 1998-03-18 | Danbiosyst Uk | Novel dosage form |
US6099259A (en) | 1998-01-26 | 2000-08-08 | Bristol Compressors, Inc. | Variable capacity compressor |
US6097927A (en) | 1998-01-27 | 2000-08-01 | Symbix, Incorporated | Active symbolic self design method and apparatus |
US6038464A (en) | 1998-02-09 | 2000-03-14 | Axelgaard Manufacturing Co., Ltd. | Medical electrode |
US6275476B1 (en) | 1998-02-19 | 2001-08-14 | Micron Technology, Inc. | Method of addressing messages and communications system |
US7542878B2 (en) | 1998-03-03 | 2009-06-02 | Card Guard Scientific Survival Ltd. | Personal health monitor and a method for health monitoring |
US6141592A (en) | 1998-03-06 | 2000-10-31 | Intermedics Inc. | Data transmission using a varying electric field |
US6579231B1 (en) | 1998-03-27 | 2003-06-17 | Mci Communications Corporation | Personal medical monitoring unit and system |
US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
ATE245937T1 (de) * | 1998-05-13 | 2003-08-15 | Cygnus Therapeutic Systems | Überwachung physiologischer analyte |
AU4094599A (en) | 1998-05-21 | 1999-12-06 | Telecom Medical, Inc. | Patient monitoring apparatus |
US6205745B1 (en) | 1998-05-27 | 2001-03-27 | Lucent Technologies Inc. | High speed flip-chip dispensing |
US6477424B1 (en) | 1998-06-19 | 2002-11-05 | Medtronic, Inc. | Medical management system integrated programming apparatus for communication with an implantable medical device |
CN1116044C (zh) * | 1998-06-24 | 2003-07-30 | 凌沛学 | 含有透明质酸钠的防粘连颗粒剂和粉雾剂及其制作方法 |
US6704602B2 (en) | 1998-07-02 | 2004-03-09 | Medtronic, Inc. | Implanted medical device/external medical instrument communication utilizing surface electrodes |
US7209787B2 (en) | 1998-08-05 | 2007-04-24 | Bioneuronics Corporation | Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease |
US7548787B2 (en) | 2005-08-03 | 2009-06-16 | Kamilo Feher | Medical diagnostic and communication system |
US6703047B2 (en) | 2001-02-02 | 2004-03-09 | Incept Llc | Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use |
US6558320B1 (en) | 2000-01-20 | 2003-05-06 | Medtronic Minimed, Inc. | Handheld personal data assistant (PDA) with a medical device and method of using the same |
US6333699B1 (en) | 1998-08-28 | 2001-12-25 | Marathon Oil Company | Method and apparatus for determining position in a pipe |
EP1109490A4 (en) | 1998-09-04 | 2005-03-02 | Wolfe Res Pty Ltd | MEDICAL PROSTHESIS SYSTEM |
WO2000016280A1 (en) | 1998-09-11 | 2000-03-23 | Key-Trak, Inc. | Object tracking system with non-contact object detection and identification |
US6344824B1 (en) | 1998-09-18 | 2002-02-05 | Hitachi Maxell, Ltd. | Noncontact communication semiconductor device |
FI116957B (fi) | 1998-10-29 | 2006-04-13 | Nokia Corp | Menetelmä langattoman laitteen ja elektroniikkalaitteen välistä tiedonsiirtoa varten ja tiedonsiirtolaite |
US6708060B1 (en) | 1998-11-09 | 2004-03-16 | Transpharma Ltd. | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
US6547994B1 (en) | 1998-11-13 | 2003-04-15 | Therics, Inc. | Rapid prototyping and manufacturing process |
US6526135B1 (en) * | 1998-11-18 | 2003-02-25 | Nortel Networks Limited | Automated competitive business call distribution (ACBCD) system |
WO2000033246A1 (en) | 1998-11-25 | 2000-06-08 | Ball Semiconductor, Inc. | Method of and system for identifying medical products |
IT1304779B1 (it) | 1998-12-03 | 2001-03-29 | Ima Spa | Dosatrice a disco ed a pestelli, a funzionamento intermittente,monogiostra, particolarmente adatta per il confezionamento di dosi |
US6217744B1 (en) | 1998-12-18 | 2001-04-17 | Peter Crosby | Devices for testing fluid |
DE69909327T2 (de) | 1998-12-21 | 2004-04-22 | Sequella, Inc. | Verwendungsmethoden und zusammenstellungen enthaltend überwachungsystem |
US6115636A (en) | 1998-12-22 | 2000-09-05 | Medtronic, Inc. | Telemetry for implantable devices using the body as an antenna |
US6269058B1 (en) | 1999-01-04 | 2001-07-31 | Texas Instruments Incorporated | Wide capture range circuitry |
US6358202B1 (en) | 1999-01-25 | 2002-03-19 | Sun Microsystems, Inc. | Network for implanted computer devices |
US8636648B2 (en) | 1999-03-01 | 2014-01-28 | West View Research, Llc | Endoscopic smart probe |
US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
US6285897B1 (en) | 1999-04-07 | 2001-09-04 | Endonetics, Inc. | Remote physiological monitoring system |
US6494829B1 (en) | 1999-04-15 | 2002-12-17 | Nexan Limited | Physiological sensor array |
US6290646B1 (en) | 1999-04-16 | 2001-09-18 | Cardiocom | Apparatus and method for monitoring and communicating wellness parameters of ambulatory patients |
US6755783B2 (en) | 1999-04-16 | 2004-06-29 | Cardiocom | Apparatus and method for two-way communication in a device for monitoring and communicating wellness parameters of ambulatory patients |
US6200265B1 (en) | 1999-04-16 | 2001-03-13 | Medtronic, Inc. | Peripheral memory patch and access method for use with an implantable medical device |
DE69913743T2 (de) | 1999-05-25 | 2004-10-07 | Medicotest As Olstykke | Hautelektrode |
EP1852836A3 (en) | 1999-05-26 | 2011-03-30 | Johnson Controls Technology Company | Wireless communications system and method |
US6366206B1 (en) | 1999-06-02 | 2002-04-02 | Ball Semiconductor, Inc. | Method and apparatus for attaching tags to medical and non-medical devices |
EP1060704A3 (en) | 1999-06-18 | 2002-09-18 | Agilent Technologies, Inc. (a Delaware corporation) | Multi-parameter capability transmitter for wireless telemetry systems |
JP3402267B2 (ja) | 1999-06-23 | 2003-05-06 | ソニーケミカル株式会社 | 電子素子の実装方法 |
DE19929328A1 (de) | 1999-06-26 | 2001-01-04 | Daimlerchrysler Aerospace Ag | Vorrichtung zur medizinischen Langzeitüberwachung von Personen |
US6287252B1 (en) | 1999-06-30 | 2001-09-11 | Monitrak | Patient monitor |
US6307468B1 (en) | 1999-07-20 | 2001-10-23 | Avid Identification Systems, Inc. | Impedance matching network and multidimensional electromagnetic field coil for a transponder interrogator |
JP2003504415A (ja) | 1999-07-20 | 2003-02-04 | メルク エンド カムパニー インコーポレーテッド | 持続放出性薬物分散剤輸送装置 |
HN2000000165A (es) | 1999-08-05 | 2001-07-09 | Dimensional Foods Corp | Productos holograficos comestibles, particularmente farmaceuticos, y metodos y aparatos para producirlos. |
US6428809B1 (en) | 1999-08-18 | 2002-08-06 | Microdose Technologies, Inc. | Metering and packaging of controlled release medication |
US6206702B1 (en) | 1999-08-24 | 2001-03-27 | Deborah A. Hayden | Methods and devices for treating unilateral neglect |
US6526034B1 (en) | 1999-09-21 | 2003-02-25 | Tantivy Communications, Inc. | Dual mode subscriber unit for short range, high rate and long range, lower rate data communications |
US6533733B1 (en) | 1999-09-24 | 2003-03-18 | Ut-Battelle, Llc | Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring |
US6990082B1 (en) | 1999-11-08 | 2006-01-24 | Intel Corporation | Wireless apparatus having a transceiver equipped to support multiple wireless communication protocols |
KR100739357B1 (ko) * | 1999-09-30 | 2007-07-18 | 소니 가부시끼 가이샤 | 기록 장치, 기록 방법 및 기록 매체 |
AU778361B2 (en) | 1999-10-07 | 2004-12-02 | La Mont, Llc | Physiological signal monitoring apparatus and method |
US6852084B1 (en) | 2000-04-28 | 2005-02-08 | Peter V. Boesen | Wireless physiological pressure sensor and transmitter with capability of short range radio frequency transmissions |
US6882881B1 (en) | 1999-10-19 | 2005-04-19 | The Johns Hopkins University | Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders |
US6426863B1 (en) | 1999-11-25 | 2002-07-30 | Lithium Power Technologies, Inc. | Electrochemical capacitor |
US6612984B1 (en) | 1999-12-03 | 2003-09-02 | Kerr, Ii Robert A. | System and method for collecting and transmitting medical data |
GB9930000D0 (en) * | 1999-12-21 | 2000-02-09 | Phaeton Research Ltd | An ingestible device |
US20020193846A1 (en) | 1999-12-21 | 2002-12-19 | Pool Nancy Perry | Instrumentation and software for remote monitoring and programming of implantable medical devices (IMDs) |
DE60039989D1 (de) | 1999-12-28 | 2008-10-02 | Matsushita Electric Ind Co Ltd | Informationsaufzeichnungsmedium und zugangseinrichtung |
US6294999B1 (en) | 1999-12-29 | 2001-09-25 | Becton, Dickinson And Company | Systems and methods for monitoring patient compliance with medication regimens |
US8002700B2 (en) | 1999-12-30 | 2011-08-23 | Medtronic, Inc. | Communications system for an implantable medical device and a delivery device |
US6471645B1 (en) | 1999-12-30 | 2002-10-29 | Medtronic, Inc. | Communications system for an implantable device and a drug dispenser |
GB0000566D0 (en) | 2000-01-12 | 2000-03-01 | Willett Int Ltd | Apparatus and method |
DE60030086T2 (de) | 2000-01-20 | 2007-01-04 | Lucent Technologies Inc. | Interoperabilität von Bluetooth und IEEE 802.11 |
US6567685B2 (en) | 2000-01-21 | 2003-05-20 | Kabushiki Kaisha Toshiba | Magnetic resonance imaging apparatus |
AR026148A1 (es) * | 2000-01-21 | 2003-01-29 | Osmotica Argentina S A | Dispositivo osmotico con pasaje preformado que aumenta de tamano |
US6368190B1 (en) | 2000-01-26 | 2002-04-09 | Agere Systems Guardian Corp. | Electrochemical mechanical planarization apparatus and method |
US7039453B2 (en) * | 2000-02-08 | 2006-05-02 | Tarun Mullick | Miniature ingestible capsule |
GB0003197D0 (en) | 2000-02-11 | 2000-04-05 | Aid Medic Ltd | Improvements in and relating to controlling drug delivery |
EP1693000B1 (en) * | 2000-03-08 | 2013-05-08 | Given Imaging Ltd. | A device for in vivo imaging |
US6526315B1 (en) | 2000-03-17 | 2003-02-25 | Tanita Corporation | Portable bioelectrical impedance measuring instrument |
DE10014588A1 (de) | 2000-03-27 | 2001-10-04 | Basf Ag | Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung |
GB0007617D0 (en) | 2000-03-29 | 2000-05-17 | Psion Dacom Plc | A short range radio transceiver device |
US6757523B2 (en) | 2000-03-31 | 2004-06-29 | Zeus Wireless, Inc. | Configuration of transmit/receive switching in a transceiver |
US6622050B2 (en) | 2000-03-31 | 2003-09-16 | Medtronic, Inc. | Variable encryption scheme for data transfer between medical devices and related data management systems |
US6922592B2 (en) | 2000-04-04 | 2005-07-26 | Medtronic, Inc. | Implantable medical device controlled by a non-invasive physiological data measurement device |
US6654638B1 (en) | 2000-04-06 | 2003-11-25 | Cardiac Pacemakers, Inc. | Ultrasonically activated electrodes |
US6496705B1 (en) | 2000-04-18 | 2002-12-17 | Motorola Inc. | Programmable wireless electrode system for medical monitoring |
US6441747B1 (en) | 2000-04-18 | 2002-08-27 | Motorola, Inc. | Wireless system protocol for telemetry monitoring |
US6561975B1 (en) | 2000-04-19 | 2003-05-13 | Medtronic, Inc. | Method and apparatus for communicating with medical device systems |
GB2361544B (en) | 2000-04-20 | 2004-07-07 | Goring Kerr Ltd | Metal detector |
US6836862B1 (en) | 2000-04-24 | 2004-12-28 | 3Com Corporation | Method of indicating wireless connection integrity |
WO2001086894A2 (en) | 2000-05-08 | 2001-11-15 | Transilica, Inc. | Transmit-only and receive-only bluetooth apparatus and method |
US6432292B1 (en) | 2000-05-16 | 2002-08-13 | Metallic Power, Inc. | Method of electrodepositing metal on electrically conducting particles |
WO2001089362A2 (en) | 2000-05-19 | 2001-11-29 | Welch Allyn Protocol Inc. | Patient monitoring system |
US6680923B1 (en) | 2000-05-23 | 2004-01-20 | Calypso Wireless, Inc. | Communication system and method |
AU6207101A (en) | 2000-05-29 | 2001-12-11 | Medicotest A/S | An electrode for establishing electrical contact with the skin |
IL163684A0 (en) | 2000-05-31 | 2005-12-18 | Given Imaging Ltd | Measurement of electrical characteristics of tissue |
GB0014855D0 (en) | 2000-06-16 | 2000-08-09 | Isis Innovation | Combining measurements from different sensors |
US7261690B2 (en) | 2000-06-16 | 2007-08-28 | Bodymedia, Inc. | Apparatus for monitoring health, wellness and fitness |
US6605038B1 (en) | 2000-06-16 | 2003-08-12 | Bodymedia, Inc. | System for monitoring health, wellness and fitness |
US20060122474A1 (en) | 2000-06-16 | 2006-06-08 | Bodymedia, Inc. | Apparatus for monitoring health, wellness and fitness |
GB0014854D0 (en) | 2000-06-16 | 2000-08-09 | Isis Innovation | System and method for acquiring data |
US7689437B1 (en) * | 2000-06-16 | 2010-03-30 | Bodymedia, Inc. | System for monitoring health, wellness and fitness |
US7527807B2 (en) * | 2000-06-21 | 2009-05-05 | Cubist Pharmaceuticals, Inc. | Compositions and methods for increasing the oral absorption of antimicrobials |
US7009946B1 (en) | 2000-06-22 | 2006-03-07 | Intel Corporation | Method and apparatus for multi-access wireless communication |
US6607744B1 (en) | 2000-06-23 | 2003-08-19 | Segan Industries | Ingestibles possessing intrinsic color change |
GB0016561D0 (en) | 2000-07-05 | 2000-08-23 | Rolls Royce Plc | Health monitoring |
US6961285B2 (en) | 2000-07-07 | 2005-11-01 | Ddms Holdings L.L.C. | Drug delivery management system |
EP1301123B1 (en) | 2000-07-19 | 2004-12-08 | Medicotest A/S | A skin electrode with a by-pass element |
AU2001277163A1 (en) | 2000-07-24 | 2002-02-05 | Motorola, Inc. | Ingestible electronic capsule |
US6564079B1 (en) | 2000-07-27 | 2003-05-13 | Ckm Diagnostics, Inc. | Electrode array and skin attachment system for noninvasive nerve location and imaging device |
JP4428835B2 (ja) | 2000-08-09 | 2010-03-10 | 昭和電工株式会社 | 磁気記録媒体及びその製造方法 |
US8036731B2 (en) | 2001-01-22 | 2011-10-11 | Spectrum Dynamics Llc | Ingestible pill for diagnosing a gastrointestinal tract |
KR20020015907A (ko) | 2000-08-23 | 2002-03-02 | 정병렬 | 심장박동수에 따른 게임제어를 통한 체력증진방법 및 그시스템 |
US20020026111A1 (en) * | 2000-08-28 | 2002-02-28 | Neil Ackerman | Methods of monitoring glucose levels in a subject and uses thereof |
US7685005B2 (en) | 2000-08-29 | 2010-03-23 | Medtronic, Inc. | Medical device systems implemented network scheme for remote patient management |
DE60102331T2 (de) | 2000-09-08 | 2005-03-17 | Matsushita Electric Works, Ltd., Kadoma | Datenübertragungssystem unter Verwendung eines menschlichen Körpers als Signalübertragungsweg |
US6720923B1 (en) | 2000-09-14 | 2004-04-13 | Stata Labs, Llc | Antenna design utilizing a cavity architecture for global positioning system (GPS) applications |
US6572636B1 (en) | 2000-09-19 | 2003-06-03 | Robert Sean Hagen | Pulse sensing patch and associated methods |
WO2002027659A2 (en) | 2000-09-26 | 2002-04-04 | Advantage 3D Llc | Method and system for generation, storage and distribution of omni-directional object views |
AU2002224453A1 (en) * | 2000-10-11 | 2002-04-22 | Microchips, Inc. | Microchip reservoir devices and facilitated corrosion of electrodes |
US7024248B2 (en) | 2000-10-16 | 2006-04-04 | Remon Medical Technologies Ltd | Systems and methods for communicating with implantable devices |
US7857626B2 (en) | 2000-10-23 | 2010-12-28 | Toly Christopher C | Medical physiological simulator including a conductive elastomer layer |
WO2002034331A2 (en) | 2000-10-26 | 2002-05-02 | Medtronic, Inc. | Externally worn transceiver for use with an implantable medical device |
US6632175B1 (en) | 2000-11-08 | 2003-10-14 | Hewlett-Packard Development Company, L.P. | Swallowable data recorder capsule medical device |
US6929636B1 (en) | 2000-11-08 | 2005-08-16 | Hewlett-Packard Development Company, L.P. | Internal drug dispenser capsule medical device |
ES2177434B1 (es) | 2000-12-05 | 2004-10-16 | Gesimpex Comercial, S.L. | Procedimiento y capsula para la identificacion y seguimiento remoto de aves. |
US20020128934A1 (en) | 2000-12-11 | 2002-09-12 | Ari Shaer | Interactive event planning and payment method and system |
US6689117B2 (en) | 2000-12-18 | 2004-02-10 | Cardiac Pacemakers, Inc. | Drug delivery system for implantable medical device |
US6879810B2 (en) | 2000-12-20 | 2005-04-12 | Nokia Corporation | Control of short range RF communication |
TW567695B (en) | 2001-01-17 | 2003-12-21 | Ibm | Digital baseband system |
KR100526699B1 (ko) | 2001-01-17 | 2005-11-08 | 이종식 | 네트워크 게임방법 및 그 시스템 |
JP2002224053A (ja) | 2001-02-05 | 2002-08-13 | Next:Kk | 遠隔医療管理システム |
JP3927495B2 (ja) | 2001-02-08 | 2007-06-06 | ミニ−ミッター カンパニー,インコーポレイテッド | 温度センサーを内蔵する皮膚用パッチ材 |
US20050208251A1 (en) | 2001-02-15 | 2005-09-22 | Integral Technologies, Inc. | Low cost electrically conductive tapes and films manufactured from conductive loaded resin-based materials |
JP2002263185A (ja) | 2001-03-12 | 2002-09-17 | Sanyo Electric Co Ltd | 投薬システム及び方法及び投薬装置 |
GB0107045D0 (en) | 2001-03-21 | 2001-05-09 | Pace Micro Tech Plc | Control system for control of power supply for lnb in broadcast data receiving system |
JP2002282219A (ja) * | 2001-03-22 | 2002-10-02 | Toshio Chiba | 体内カプセル |
JP2002290212A (ja) | 2001-03-27 | 2002-10-04 | Nec Corp | 電圧制御発振器 |
US6342774B1 (en) | 2001-03-27 | 2002-01-29 | Motorola, Inc. | Battery having user charge capacity control |
JP2005500869A (ja) | 2001-03-28 | 2005-01-13 | テレバイタル・インコーポレイテッド | 広域ネットワークによる生理学的データの実時間モニタリング、判断、解析、検索および記憶を行うためのシステムおよび方法 |
JP2002291684A (ja) | 2001-03-29 | 2002-10-08 | Olympus Optical Co Ltd | 外科手術用内視鏡及び外套管 |
US6595929B2 (en) | 2001-03-30 | 2003-07-22 | Bodymedia, Inc. | System for monitoring health, wellness and fitness having a method and apparatus for improved measurement of heat flow |
GB0108208D0 (en) | 2001-04-02 | 2001-05-23 | Glaxo Group Ltd | Medicament dispenser |
JP2004527296A (ja) | 2001-04-02 | 2004-09-09 | エヌ アイ メディカル リミテッド | 血行動態の測定用装置 |
US7407484B2 (en) | 2001-04-06 | 2008-08-05 | Medic4All Inc. | Physiological monitoring system for a computational device of a human subject |
US6694161B2 (en) | 2001-04-20 | 2004-02-17 | Monsanto Technology Llc | Apparatus and method for monitoring rumen pH |
US6801137B2 (en) | 2001-04-23 | 2004-10-05 | Cardionet, Inc. | Bidirectional communication between a sensor unit and a monitor unit in patient monitoring |
US6782290B2 (en) | 2001-04-27 | 2004-08-24 | Medtronic, Inc. | Implantable medical device with rechargeable thin-film microbattery power source |
AU2002305313A1 (en) | 2001-04-30 | 2002-11-11 | Medtronic, Inc. | Implantable medical device and patch system |
WO2002089667A1 (en) | 2001-05-03 | 2002-11-14 | Telzuit Technologies, Inc. | Wireless medical monitoring apparatus and system |
US7039033B2 (en) | 2001-05-07 | 2006-05-02 | Ixi Mobile (Israel) Ltd. | System, device and computer readable medium for providing a managed wireless network using short-range radio signals |
JP4674038B2 (ja) | 2001-05-20 | 2011-04-20 | ギブン イメージング リミテッド | 生体内センシング装置 |
BRPI0209720A2 (pt) | 2001-05-31 | 2017-06-13 | Microdose Tech Inc | dosagem e embalagem de medicação com liberação controlada |
GB0113212D0 (en) | 2001-05-31 | 2001-07-25 | Oxford Biosignals Ltd | Patient condition display |
US20020192159A1 (en) | 2001-06-01 | 2002-12-19 | Reitberg Donald P. | Single-patient drug trials used with accumulated database: flowchart |
US20020179921A1 (en) | 2001-06-02 | 2002-12-05 | Cohn Michael B. | Compliant hermetic package |
DE60228266D1 (de) | 2001-06-18 | 2008-09-25 | Given Imaging Ltd | Schluckbare in vivo-erfassungskapsel mit einer starre und flexible abschnitte aufweisenden leiterplatte |
EP1408822A2 (en) | 2001-06-19 | 2004-04-21 | Digital Sports Media | Physiological monitoring and system |
EP1399309A1 (en) | 2001-06-25 | 2004-03-24 | Pharmacia Corporation | Compression coated tablets |
US7160258B2 (en) * | 2001-06-26 | 2007-01-09 | Entrack, Inc. | Capsule and method for treating or diagnosing the intestinal tract |
US6602518B2 (en) | 2001-06-28 | 2003-08-05 | Wm. Wrigley Jr. Company | Chewable product including active ingredient |
US7044911B2 (en) | 2001-06-29 | 2006-05-16 | Philometron, Inc. | Gateway platform for biological monitoring and delivery of therapeutic compounds |
NZ530434A (en) | 2001-07-02 | 2005-01-28 | Battelle Memorial Institute | Intelligent microsensor module |
ATE433163T1 (de) | 2001-07-11 | 2009-06-15 | Cns Response Inc | Verfahren zur vorhersage der behandlungsresultate |
JP4307995B2 (ja) * | 2001-07-12 | 2009-08-05 | ギブン イメージング リミテッド | 身体の管腔を検査するための装置 |
US20030017826A1 (en) | 2001-07-17 | 2003-01-23 | Dan Fishman | Short-range wireless architecture |
US7368191B2 (en) | 2001-07-25 | 2008-05-06 | Biosource, Inc. | Electrode array for use in electrochemical cells |
FR2827919B1 (fr) | 2001-07-26 | 2004-03-05 | Thermodyn | Garniture d'etancheite pour compresseur et compresseur centrifuge pourvu d'une telle garniture |
US7257438B2 (en) | 2002-07-23 | 2007-08-14 | Datascope Investment Corp. | Patient-worn medical monitoring device |
US6951536B2 (en) * | 2001-07-30 | 2005-10-04 | Olympus Corporation | Capsule-type medical device and medical system |
US6747556B2 (en) | 2001-07-31 | 2004-06-08 | Medtronic Physio-Control Corp. | Method and system for locating a portable medical device |
JP2003050867A (ja) | 2001-08-08 | 2003-02-21 | Nippon Signal Co Ltd:The | 歩行者等健康チェック支援方法及びその装置 |
US20030065536A1 (en) | 2001-08-13 | 2003-04-03 | Hansen Henrik Egesborg | Portable device and method of communicating medical data information |
WO2003015890A1 (en) * | 2001-08-20 | 2003-02-27 | President And Fellows Of Harvard College | Fluidic arrays and method of using |
JP3962250B2 (ja) | 2001-08-29 | 2007-08-22 | 株式会社レアメタル | 生体内情報検出システム及びこれに用いるタグ装置、中継装置 |
US6650191B2 (en) | 2001-09-07 | 2003-11-18 | Texas Instruments Incorporated | Low jitter ring oscillator architecture |
JP3857271B2 (ja) | 2001-09-21 | 2006-12-13 | トック・エンジニアリング株式会社 | 金属異物検知方法とその装置 |
US6604650B2 (en) | 2001-09-28 | 2003-08-12 | Koninklijke Philips Electronics N.V. | Bottle-cap medication reminder and overdose safeguard |
US6767200B2 (en) | 2001-09-28 | 2004-07-27 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
US7122143B2 (en) | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
US6982094B2 (en) | 2001-09-28 | 2006-01-03 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
MXPA04002980A (es) | 2001-09-28 | 2005-06-20 | Johnson & Johnson | Formas de dosificacion que tienen un nucleo interior y coraza exterior con diferentes formas. |
US20050137480A1 (en) | 2001-10-01 | 2005-06-23 | Eckhard Alt | Remote control of implantable device through medical implant communication service band |
US20030062551A1 (en) | 2001-10-02 | 2003-04-03 | Jds Uniphase Corporation | Electrode structure including encapsulated adhesion layer |
US6840904B2 (en) | 2001-10-11 | 2005-01-11 | Jason Goldberg | Medical monitoring device and system |
US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
US6745082B2 (en) | 2001-10-22 | 2004-06-01 | Jens Axelgaard | Current-controlling electrode with adjustable contact area |
US20030152622A1 (en) | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
US20030083559A1 (en) | 2001-10-31 | 2003-05-01 | Thompson David L. | Non-contact monitor |
US6643541B2 (en) | 2001-12-07 | 2003-11-04 | Motorola, Inc | Wireless electromyography sensor and system |
US20030107487A1 (en) | 2001-12-10 | 2003-06-12 | Ronen Korman | Method and device for measuring physiological parameters at the wrist |
AU2002352369A1 (en) | 2001-12-10 | 2003-07-09 | Innovision Research And Technology Plc | Detectable components and detection apparatus for detecting such components |
GB0130010D0 (en) | 2001-12-14 | 2002-02-06 | Isis Innovation | Combining measurements from breathing rate sensors |
US7016648B2 (en) | 2001-12-18 | 2006-03-21 | Ixi Mobile (Israel) Ltd. | Method, system and computer readable medium for downloading a software component to a device in a short distance wireless network |
US7729776B2 (en) | 2001-12-19 | 2010-06-01 | Cardiac Pacemakers, Inc. | Implantable medical device with two or more telemetry systems |
US7035877B2 (en) | 2001-12-28 | 2006-04-25 | Kimberly-Clark Worldwide, Inc. | Quality management and intelligent manufacturing with labels and smart tags in event-based product manufacturing |
US7877273B2 (en) | 2002-01-08 | 2011-01-25 | Fredric David Abramson | System and method for evaluating and providing nutrigenomic data, information and advice |
CA2472226A1 (en) | 2002-01-11 | 2003-07-24 | Hexalog Sa | Systems and methods for medication monitoring |
JP3957272B2 (ja) * | 2002-01-22 | 2007-08-15 | オリンパス株式会社 | カプセル型医療装置 |
US7169107B2 (en) | 2002-01-25 | 2007-01-30 | Karen Jersey-Willuhn | Conductivity reconstruction based on inverse finite element measurements in a tissue monitoring system |
JP2003212965A (ja) | 2002-01-28 | 2003-07-30 | Brother Ind Ltd | 活性エネルギー線硬化型組成物 |
US7519416B2 (en) * | 2002-02-04 | 2009-04-14 | Heartview, Llc | Diagnostic method utilizing standard lead ECG signals |
FR2835730B1 (fr) | 2002-02-11 | 2004-12-10 | C T M Ct De Transfert Des Micr | Dispositif pour la delivrance de substances et le prelevement intracorporel |
IL154391A (en) * | 2002-02-11 | 2009-05-04 | Given Imaging Ltd | Self-propelled device |
US6935560B2 (en) | 2002-02-26 | 2005-08-30 | Safety Syringes, Inc. | Systems and methods for tracking pharmaceuticals within a facility |
US8660645B2 (en) | 2002-02-28 | 2014-02-25 | Greatbatch Ltd. | Electronic network components utilizing biocompatible conductive adhesives for direct body fluid exposure |
US20030162556A1 (en) | 2002-02-28 | 2003-08-28 | Libes Michael A. | Method and system for communication between two wireless-enabled devices |
US7468032B2 (en) | 2002-12-18 | 2008-12-23 | Cardiac Pacemakers, Inc. | Advanced patient management for identifying, displaying and assisting with correlating health-related data |
US7043305B2 (en) | 2002-03-06 | 2006-05-09 | Cardiac Pacemakers, Inc. | Method and apparatus for establishing context among events and optimizing implanted medical device performance |
US6957107B2 (en) | 2002-03-13 | 2005-10-18 | Cardionet, Inc. | Method and apparatus for monitoring and communicating with an implanted medical device |
US6968153B1 (en) | 2002-03-13 | 2005-11-22 | Nokia Corporation | Apparatus, method and system for a Bluetooth repeater |
US7188767B2 (en) | 2002-03-18 | 2007-03-13 | Precision Dynamics Corporation | Physical condition or environmental threat detection appliance system |
US7022070B2 (en) | 2002-03-22 | 2006-04-04 | Mini-Mitter Co., Inc. | Method for continuous monitoring of patients to detect the potential onset of sepsis |
US6850788B2 (en) | 2002-03-25 | 2005-02-01 | Masimo Corporation | Physiological measurement communications adapter |
JP3869291B2 (ja) | 2002-03-25 | 2007-01-17 | オリンパス株式会社 | カプセル型医療装置 |
US7376435B2 (en) | 2002-04-01 | 2008-05-20 | Intel Corporation | Transferring multiple data units over a wireless communication link |
US7797033B2 (en) * | 2002-04-08 | 2010-09-14 | Smart Pill Corporation | Method of using, and determining location of, an ingestible capsule |
US7654901B2 (en) | 2002-04-10 | 2010-02-02 | Breving Joel S | Video game system using bio-feedback devices |
US7645262B2 (en) | 2002-04-11 | 2010-01-12 | Second Sight Medical Products, Inc. | Biocompatible bonding method and electronics package suitable for implantation |
US6942770B2 (en) | 2002-04-19 | 2005-09-13 | Nova Biomedical Corporation | Disposable sub-microliter volume biosensor with enhanced sample inlet |
US7187960B2 (en) | 2002-04-22 | 2007-03-06 | Marcio Marc Abreu | Apparatus and method for measuring biologic parameters |
US7424268B2 (en) | 2002-04-22 | 2008-09-09 | Cisco Technology, Inc. | System and method for management of a shared frequency band |
EP1356762A1 (de) | 2002-04-22 | 2003-10-29 | UbiCom Gesellschaft für Telekommunikation mbH | Geräteanordnung zur Fernüberwachung von Körperfunktionen |
AU2003234159A1 (en) | 2002-04-22 | 2003-11-03 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
US7697995B2 (en) * | 2002-04-25 | 2010-04-13 | Medtronic, Inc. | Surgical lead paddle |
US20030216622A1 (en) | 2002-04-25 | 2003-11-20 | Gavriel Meron | Device and method for orienting a device in vivo |
US20040167465A1 (en) | 2002-04-30 | 2004-08-26 | Mihai Dan M. | System and method for medical device authentication |
TW553735B (en) | 2002-05-01 | 2003-09-21 | Jin-Shing Luo | Common electrode using human body as common electric reservoir and application thereof |
US7368190B2 (en) | 2002-05-02 | 2008-05-06 | Abbott Diabetes Care Inc. | Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods |
US7901939B2 (en) * | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
US6946156B2 (en) * | 2002-05-15 | 2005-09-20 | Mcneil-Ppc, Inc. | Process for enrobing a core |
JP2003325439A (ja) * | 2002-05-15 | 2003-11-18 | Olympus Optical Co Ltd | カプセル型医療装置 |
JP4187463B2 (ja) * | 2002-05-16 | 2008-11-26 | オリンパス株式会社 | カプセル医療装置 |
JP2004041709A (ja) | 2002-05-16 | 2004-02-12 | Olympus Corp | カプセル医療装置 |
US20030216729A1 (en) | 2002-05-20 | 2003-11-20 | Marchitto Kevin S. | Device and method for wound healing and uses therefor |
GB0211620D0 (en) | 2002-05-21 | 2002-07-03 | Bioprogress Technology Ltd | Powder compaction and enrobing |
JP3576150B2 (ja) | 2002-05-31 | 2004-10-13 | 株式会社東芝 | 中継装置と電源制御方法 |
US6847844B2 (en) | 2002-06-06 | 2005-01-25 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of data communication with implanted device and associated apparatus |
US6864692B1 (en) | 2002-06-20 | 2005-03-08 | Xsilogy, Inc. | Sensor having improved selectivity |
US8003179B2 (en) * | 2002-06-20 | 2011-08-23 | Alcan Packaging Flexible France | Films having a desiccant material incorporated therein and methods of use and manufacture |
DE60331833D1 (de) | 2002-07-01 | 2010-05-06 | Nicholas C Hopman | Drahtlose ekg-vorrichtung |
US20060129060A1 (en) | 2002-07-02 | 2006-06-15 | Healthpia America | Management method of fat mass and management device of fat mass using mobile phone |
US20040008123A1 (en) | 2002-07-15 | 2004-01-15 | Battelle Memorial Institute | System and method for tracking medical devices |
AU2003213529B2 (en) | 2002-07-19 | 2005-01-20 | Panasonic Healthcare Holdings Co., Ltd. | ZrO2-AI2O3 composite ceramic material and production method thereof |
FR2842721B1 (fr) | 2002-07-25 | 2005-06-24 | Assist Publ Hopitaux De Paris | Procede d'exploration non invasif et ambulatoire de la motricite digestive et du transit, et systeme correspondant |
US20040019172A1 (en) | 2002-07-26 | 2004-01-29 | Tou-Hsiung Yang | Biodegradable, water absorbable resin and its preparation method |
US7211349B2 (en) | 2002-08-06 | 2007-05-01 | Wilson Greatbatch Technologies, Inc. | Silver vanadium oxide provided with a metal oxide coating |
US20040143182A1 (en) | 2002-08-08 | 2004-07-22 | Pavel Kucera | System and method for monitoring and stimulating gastro-intestinal motility |
US6909878B2 (en) | 2002-08-20 | 2005-06-21 | Ixi Mobile (Israel) Ltd. | Method, system and computer readable medium for providing an output signal having a theme to a device in a short distance wireless network |
US7020508B2 (en) | 2002-08-22 | 2006-03-28 | Bodymedia, Inc. | Apparatus for detecting human physiological and contextual information |
US7294105B1 (en) | 2002-09-03 | 2007-11-13 | Cheetah Omni, Llc | System and method for a wireless medical communication system |
DE60305817T2 (de) | 2002-09-04 | 2007-01-11 | Broadcom Corp., Irvine | System und Verfahren zur Optimierung von Stromverbrauch in einer mobilen Umgebung |
US7102508B2 (en) | 2002-09-09 | 2006-09-05 | Persephone, Inc. | Method and apparatus for locating and tracking persons |
US20040049245A1 (en) | 2002-09-09 | 2004-03-11 | Volker Gass | Autonomous patch for communication with an implantable device, and medical kit for using said patch |
GB2393356B (en) | 2002-09-18 | 2006-02-01 | E San Ltd | Telemedicine system |
US7388903B2 (en) | 2002-09-18 | 2008-06-17 | Conexant, Inc. | Adaptive transmission rate and fragmentation threshold mechanism for local area networks |
US7118531B2 (en) | 2002-09-24 | 2006-10-10 | The Johns Hopkins University | Ingestible medical payload carrying capsule with wireless communication |
US6842636B2 (en) | 2002-09-27 | 2005-01-11 | Axelgaard Manufacturing Co., Ltd. | Medical electrode |
US7736309B2 (en) | 2002-09-27 | 2010-06-15 | Medtronic Minimed, Inc. | Implantable sensor method and system |
US7209790B2 (en) | 2002-09-30 | 2007-04-24 | Medtronic, Inc. | Multi-mode programmer for medical device communication |
US7686762B1 (en) | 2002-10-03 | 2010-03-30 | Integrated Sensing Systems, Inc. | Wireless device and system for monitoring physiologic parameters |
ES2562933T3 (es) | 2002-10-09 | 2016-03-09 | Bodymedia, Inc. | Aparato para detectar, recibir, obtener y presentar información fisiológica y contextual humana |
US20040073454A1 (en) | 2002-10-10 | 2004-04-15 | John Urquhart | System and method of portal-mediated, website-based analysis of medication dosing |
US6959217B2 (en) | 2002-10-24 | 2005-10-25 | Alfred E. Mann Foundation For Scientific Research | Multi-mode crystal oscillator system selectively configurable to minimize power consumption or noise generation |
US7027871B2 (en) | 2002-10-31 | 2006-04-11 | Medtronic, Inc. | Aggregation of data from external data sources within an implantable medical device |
US6773360B2 (en) | 2002-11-08 | 2004-08-10 | Taylor Made Golf Company, Inc. | Golf club head having a removable weight |
US20030126593A1 (en) | 2002-11-04 | 2003-07-03 | Mault James R. | Interactive physiological monitoring system |
EP1437784B1 (en) | 2002-11-08 | 2012-05-30 | Honda Motor Co., Ltd. | Electrode for solid polymer fuel cell |
US20040092801A1 (en) | 2002-11-13 | 2004-05-13 | Budimir Drakulic | System for, and method of, acquiring physiological signals of a patient |
GB2395613B (en) | 2002-11-21 | 2006-09-06 | Hewlett Packard Co | Memory tag,read/write device and method of operating a memory tag |
US20050288594A1 (en) | 2002-11-29 | 2005-12-29 | Shlomo Lewkowicz | Methods, device and system for in vivo diagnosis |
US20040115507A1 (en) | 2002-12-05 | 2004-06-17 | Potter Curtis N | Monolithic fuel cell and method of manufacture |
CA2508800A1 (en) | 2002-12-11 | 2004-06-24 | Proteus Biomedical, Inc. | Method and system for monitoring and treating hemodynamic parameters |
AU2003283688A1 (en) | 2002-12-11 | 2004-06-30 | Pfizer Products Inc. | Controlled-release of an active substance into a high fat environment |
US20040167226A1 (en) | 2002-12-16 | 2004-08-26 | Serafini Tito A. | Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same |
JP2006509574A (ja) | 2002-12-16 | 2006-03-23 | ギブン イメージング リミテッド | 生体内センサの選択的作動のための装置、システム、及び方法 |
US7009511B2 (en) | 2002-12-17 | 2006-03-07 | Cardiac Pacemakers, Inc. | Repeater device for communications with an implantable medical device |
EP1590039A1 (en) | 2002-12-19 | 2005-11-02 | Koninklijke Philips Electronics N.V. | An electrode assembly and a system with impedance control |
US7127300B2 (en) | 2002-12-23 | 2006-10-24 | Cardiac Pacemakers, Inc. | Method and apparatus for enabling data communication between an implantable medical device and a patient management system |
US7547278B2 (en) | 2002-12-27 | 2009-06-16 | Matsushita Electric Industrial Co., Ltd. | Tele-care monitoring device |
DE10261748B4 (de) | 2002-12-30 | 2011-07-28 | Mate Precision Tooling GmbH, 61440 | Stanzwerkzeug |
US7505029B2 (en) * | 2002-12-31 | 2009-03-17 | Intel Corporation | System and method for controlling multiple processing units with a single input device |
US6975174B1 (en) | 2002-12-31 | 2005-12-13 | Radioframe Networks, Inc. | Clock oscillator |
US7396330B2 (en) | 2003-01-07 | 2008-07-08 | Triage Data Networks | Wireless, internet-based medical-diagnostic system |
US20060142648A1 (en) | 2003-01-07 | 2006-06-29 | Triage Data Networks | Wireless, internet-based, medical diagnostic system |
US7512448B2 (en) | 2003-01-10 | 2009-03-31 | Phonak Ag | Electrode placement for wireless intrabody communication between components of a hearing system |
KR100873683B1 (ko) | 2003-01-25 | 2008-12-12 | 한국과학기술연구원 | 인체통신방법, 인체통신시스템 및 이에 사용되는 캡슐형 내시경 |
KR100522132B1 (ko) | 2003-01-25 | 2005-10-18 | 한국과학기술연구원 | 인체통신시스템에서의 데이터 수신방법 및 수신장치 |
US20040267240A1 (en) * | 2003-01-29 | 2004-12-30 | Yossi Gross | Active drug delivery in the gastrointestinal tract |
EP1594477A4 (en) | 2003-01-29 | 2009-07-15 | Pill Pharma Ltd E | ACTIVE MEDICATION CONTRIBUTION IN THE DIGESTIVE TUBE |
US7002476B2 (en) | 2003-01-30 | 2006-02-21 | Leap Of Faith Technologies, Inc. | Medication compliance system |
EP1443780B1 (en) | 2003-01-30 | 2013-05-29 | Accenture Global Services Limited | Event data acquisition and transmission system |
US7149581B2 (en) | 2003-01-31 | 2006-12-12 | Medtronic, Inc. | Patient monitoring device with multi-antenna receiver |
US6933026B2 (en) | 2003-02-06 | 2005-08-23 | Aradgim Corporation | Method to reduce damage caused by irradiation of halogenated polymers |
US7392015B1 (en) | 2003-02-14 | 2008-06-24 | Calamp Corp. | Calibration methods and structures in wireless communications systems |
US7215660B2 (en) | 2003-02-14 | 2007-05-08 | Rearden Llc | Single transceiver architecture for a wireless network |
EP1594551A2 (en) | 2003-02-19 | 2005-11-16 | Sicel Technologies, Inc. | In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes |
JP4114143B2 (ja) * | 2003-02-27 | 2008-07-09 | ソニー株式会社 | 通信システム、通信方法及び通信装置 |
EP1598965A4 (en) | 2003-02-27 | 2008-12-31 | Kiyoaki Takicuchi | COMMUNICATION SYSTEM |
JP4158097B2 (ja) | 2003-02-27 | 2008-10-01 | ソニー株式会社 | 認証システム |
US6888337B2 (en) | 2003-03-04 | 2005-05-03 | Hewlett-Packard Development Company, L.P. | Power system and method |
US7653031B2 (en) | 2003-03-05 | 2010-01-26 | Timothy Gordon Godfrey | Advance notification of transmit opportunities on a shared-communications channel |
US7155232B2 (en) | 2003-03-05 | 2006-12-26 | Conexant Systems, Inc. | Transmit request signaling between transceivers |
WO2004084720A2 (en) | 2003-03-21 | 2004-10-07 | Welch Allyn, Inc. | Personal status physiologic monitor system and architecture and related monitoring methods |
US7321920B2 (en) | 2003-03-21 | 2008-01-22 | Vocel, Inc. | Interactive messaging system |
DE10313005B4 (de) * | 2003-03-24 | 2007-05-03 | Siemens Ag | Reservebatterie und Verfahren zu deren Herstellung |
US20040193446A1 (en) * | 2003-03-27 | 2004-09-30 | Mayer Steven Lloyd | System and method for managing a patient treatment program including a prescribed drug regimen |
US7245954B2 (en) * | 2003-03-27 | 2007-07-17 | Given Imaging Ltd. | Measuring a gradient in-vivo |
GB0308114D0 (en) | 2003-04-08 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
AU2004229464A1 (en) * | 2003-04-08 | 2004-10-28 | Progenics Pharmaceuticals, Inc. | Combination therapy for constipation comprising a laxative and a peripheral opioid antagonist |
GB0308467D0 (en) | 2003-04-11 | 2003-05-21 | Rolls Royce Plc | Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components |
JP4593083B2 (ja) | 2003-04-11 | 2010-12-08 | オリンパス株式会社 | 検査データ管理方法 |
US7972616B2 (en) | 2003-04-17 | 2011-07-05 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
FI116117B (fi) | 2003-04-17 | 2005-09-30 | Polar Electro Oy | Mittalaite ja menetelmä sykkeen mittaamiseksi sekä mittalaitteen valmistusmenetelmä |
AU2004233670B2 (en) | 2003-04-25 | 2007-11-29 | Olympus Corporation | Radio-type in-subject information acquisition system and outside-subject device |
US20040218683A1 (en) | 2003-05-01 | 2004-11-04 | Texas Instruments Incorporated | Multi-mode wireless devices having reduced-mode receivers |
US20040225199A1 (en) | 2003-05-08 | 2004-11-11 | Evanyk Shane Walter | Advanced physiological monitoring systems and methods |
TWI226761B (en) | 2003-05-08 | 2005-01-11 | Ind Tech Res Inst | Dual band transceiver architecture for wireless application |
US7031745B2 (en) | 2003-05-12 | 2006-04-18 | Shen Ein-Yiao | Cellular phone combined physiological condition examination and processing device |
JP4402655B2 (ja) * | 2003-05-14 | 2010-01-20 | オリンパス株式会社 | カプセル型医療装置 |
US7311665B2 (en) | 2003-05-19 | 2007-12-25 | Alcohol Monitoring Systems, Inc. | Bio-information sensor monitoring system and method |
KR100542101B1 (ko) | 2003-06-02 | 2006-01-11 | 삼성전자주식회사 | 전송 파워 제어 방법 및 이를 이용한 블루투스 장치 |
US7188199B2 (en) | 2003-06-03 | 2007-03-06 | Silicon Labs Cp, Inc. | DMA controller that restricts ADC from memory without interrupting generation of digital words when CPU accesses memory |
US20040249257A1 (en) | 2003-06-04 | 2004-12-09 | Tupin Joe Paul | Article of manufacture for extracting physiological data using ultra-wideband radar and improved signal processing techniques |
JP4414682B2 (ja) | 2003-06-06 | 2010-02-10 | オリンパス株式会社 | 超音波内視鏡装置 |
US7313163B2 (en) | 2003-06-17 | 2007-12-25 | Motorola, Inc. | Fast synchronization for half duplex digital communications |
US7252152B2 (en) | 2003-06-18 | 2007-08-07 | Weatherford/Lamb, Inc. | Methods and apparatus for actuating a downhole tool |
US20040260154A1 (en) | 2003-06-18 | 2004-12-23 | Boris Sidelnik | Human physiological and chemical monitoring system |
WO2004112592A1 (ja) * | 2003-06-24 | 2004-12-29 | Olympus Corporation | カプセル型医療装置通信システム、カプセル型医療装置及び生体情報受信装置 |
WO2005006968A1 (en) | 2003-07-16 | 2005-01-27 | Koninklijke Philips Electronics N.V. | A portable electronic device and a health management system arranged for monitoring a physiological condition of an individual |
WO2005007223A2 (en) * | 2003-07-16 | 2005-01-27 | Sasha John | Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations |
US7554452B2 (en) | 2003-07-18 | 2009-06-30 | Cary Cole | Ingestible tracking and locating device |
US7442164B2 (en) | 2003-07-23 | 2008-10-28 | Med-El Elektro-Medizinische Gerate Gesellschaft M.B.H. | Totally implantable hearing prosthesis |
US7653350B2 (en) | 2003-07-24 | 2010-01-26 | Sony Ericsson Mobile Communications Ab | Wireless terminals and methods for communicating over cellular and enhanced mode bluetooth communication links |
JP4038575B2 (ja) * | 2003-07-25 | 2008-01-30 | 独立行政法人産業技術総合研究所 | バイオセンサ、バイオセンサ装置またはバイオセンサの保存方法 |
US7243118B2 (en) | 2003-07-30 | 2007-07-10 | Broadcom Corporation | Method and apparatus for efficient derivation of modulo arithmetic for frequency selection |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
WO2005016558A2 (en) * | 2003-08-04 | 2005-02-24 | Microchips, Inc. | Methods for accelerated release of material from a reservoir device |
ATE413902T1 (de) | 2003-08-18 | 2008-11-15 | Cardiac Pacemakers Inc | Patientenüberwachungssystem |
EP2382920A1 (en) | 2003-08-20 | 2011-11-02 | Philometron, Inc. | Hydration monitoring |
US20050172958A1 (en) | 2003-08-20 | 2005-08-11 | The Brigham And Women's Hospital, Inc. | Inhalation device and system for the remote monitoring of drug administration |
US8346482B2 (en) * | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
JP4398204B2 (ja) | 2003-08-29 | 2010-01-13 | オリンパス株式会社 | 被検体内導入装置および無線型被検体内情報取得システム |
WO2005024687A1 (ja) * | 2003-09-02 | 2005-03-17 | Fujitsu Limited | 薬服用状況管理方法、薬剤及び薬服用状況管理装置 |
US20050062644A1 (en) | 2003-09-08 | 2005-03-24 | Leci Jonathan Ilan | Capsule device to identify the location of an individual |
JP3993546B2 (ja) | 2003-09-08 | 2007-10-17 | オリンパス株式会社 | 被検体内導入装置および無線型被検体内情報取得システム |
KR101330431B1 (ko) | 2003-09-11 | 2013-11-20 | 테라노스, 인코포레이티드 | 피분석물의 모니터링 및 약물 전달을 위한 의료 기기 |
US7499674B2 (en) | 2003-09-12 | 2009-03-03 | Nokia Corporation | Method and system for repeat request in hybrid ultra wideband-bluetooth radio |
US7352998B2 (en) | 2003-09-12 | 2008-04-01 | Nokia Corporation | Method and system for establishing a wireless communications link |
EP2319410A1 (en) | 2003-09-12 | 2011-05-11 | BodyMedia, Inc. | Apparatus for measuring heart related parameters |
JP4153852B2 (ja) | 2003-09-18 | 2008-09-24 | オリンパス株式会社 | エネルギー供給用コイルおよびこれを用いた無線型被検体内情報取得システム |
US20090157358A1 (en) | 2003-09-22 | 2009-06-18 | Hyeung-Yun Kim | System for diagnosing and monitoring structural health conditions |
JP2007511741A (ja) | 2003-09-22 | 2007-05-10 | ヒョン−ユン,キム | 構造ヘルス状態モニタ方法 |
US7218967B2 (en) | 2003-09-26 | 2007-05-15 | Medtronic, Inc. | System and method for real-time remote monitoring of implantable medical devices |
JP2005102959A (ja) | 2003-09-30 | 2005-04-21 | Seiko Epson Corp | 脈波検出器及びこれを使用した脈波検出装置 |
JP4503979B2 (ja) | 2003-10-22 | 2010-07-14 | オリンパス株式会社 | 体内装置および医療機器 |
US20050075145A1 (en) | 2003-10-03 | 2005-04-07 | Dvorak Joseph L. | Method and system for coordinating use of objects using wireless communications |
EP1526651B1 (en) | 2003-10-23 | 2006-05-24 | Sony Ericsson Mobile Communications AB | Additional regulation of the reference signal of the automatic power control in a mobile terminal |
US20050096514A1 (en) | 2003-11-01 | 2005-05-05 | Medtronic, Inc. | Gastric activity notification |
EP1694200B1 (en) | 2003-11-03 | 2010-09-29 | MicroCHIPS, Inc. | Medical device for sensing glucose |
US6892590B1 (en) | 2003-11-04 | 2005-05-17 | Andermotion Technologies Llc | Single-balanced shield electrode configuration for use in capacitive displacement sensing systems and methods |
US7101343B2 (en) | 2003-11-05 | 2006-09-05 | Temple University Of The Commonwealth System Of Higher Education | Implantable telemetric monitoring system, apparatus, and method |
US20050101843A1 (en) | 2003-11-06 | 2005-05-12 | Welch Allyn, Inc. | Wireless disposable physiological sensor |
US7415242B1 (en) | 2003-11-10 | 2008-08-19 | Sprint Spectrum L.P. | Method and system for proximity detection for an in-building wireless repeater |
DE102004032812B4 (de) | 2003-11-11 | 2006-07-20 | Dräger Safety AG & Co. KGaA | Kombinationssensor für physiologische Messgrößen |
JP2005158770A (ja) | 2003-11-20 | 2005-06-16 | Matsushita Electric Ind Co Ltd | 積層基板とその製造方法及び前記積層基板を用いたモジュールの製造方法とその製造装置 |
WO2005053517A1 (ja) | 2003-12-01 | 2005-06-16 | Olympus Corporation | 内視鏡システム |
US6987691B2 (en) | 2003-12-02 | 2006-01-17 | International Business Machines Corporation | Easy axis magnetic amplifier |
US7427266B2 (en) * | 2003-12-15 | 2008-09-23 | Hewlett-Packard Development Company, L.P. | Method and apparatus for verification of ingestion |
US8306592B2 (en) | 2003-12-19 | 2012-11-06 | Olympus Corporation | Capsule medical device |
JP4198045B2 (ja) | 2003-12-25 | 2008-12-17 | オリンパス株式会社 | 被検体内位置検出システム |
JP2005185567A (ja) | 2003-12-25 | 2005-07-14 | Olympus Corp | 医療用カプセル装置 |
US8185191B1 (en) | 2003-12-29 | 2012-05-22 | Michael Evan Shapiro | Pulse monitoring and warning system for infants |
US7392091B2 (en) | 2003-12-30 | 2008-06-24 | Cochlear Limited | Implanted antenna and radio communications link |
JP2005193535A (ja) * | 2004-01-07 | 2005-07-21 | Alps Electric Co Ltd | サーマルヘッド及びその製造方法、並びにサーマルヘッドのドットアスペクト比調整方法 |
JP2005192821A (ja) | 2004-01-07 | 2005-07-21 | Olympus Corp | カプセル型医療装置 |
US7081807B2 (en) | 2004-01-14 | 2006-07-25 | Joseph Lai | Automatic pill reminder bottles |
US7176784B2 (en) | 2004-01-21 | 2007-02-13 | Battelle Memorial Institute K1-53 | Multi-mode radio frequency device |
US7375733B2 (en) | 2004-01-28 | 2008-05-20 | Canon Kabushiki Kaisha | Method for driving image display apparatus |
US7342895B2 (en) | 2004-01-30 | 2008-03-11 | Mark Serpa | Method and system for peer-to-peer wireless communication over unlicensed communication spectrum |
US7647112B2 (en) | 2004-02-11 | 2010-01-12 | Ethicon, Inc. | System and method for selectively stimulating different body parts |
US20060154642A1 (en) | 2004-02-20 | 2006-07-13 | Scannell Robert F Jr | Medication & health, environmental, and security monitoring, alert, intervention, information and network system with associated and supporting apparatuses |
US20050187789A1 (en) | 2004-02-25 | 2005-08-25 | Cardiac Pacemakers, Inc. | Advanced patient and medication therapy management system and method |
ATE473678T1 (de) | 2004-02-27 | 2010-07-15 | Koninkl Philips Electronics Nv | Tragbare drahtlose vorrichtung zur überwachung, analyse und mitteilung des physiologischen status |
CN1284505C (zh) | 2004-02-28 | 2006-11-15 | 重庆金山科技(集团)有限公司 | 医用无线电胶囊式内窥系统 |
US7406105B2 (en) | 2004-03-03 | 2008-07-29 | Alfred E. Mann Foundation For Scientific Research | System and method for sharing a common communication channel between multiple systems of implantable medical devices |
JP4488315B2 (ja) | 2004-03-04 | 2010-06-23 | オリンパス株式会社 | カプセル型医療システム |
GB0405798D0 (en) | 2004-03-15 | 2004-04-21 | E San Ltd | Medical data display |
DK1734858T3 (da) | 2004-03-22 | 2014-10-20 | Bodymedia Inc | Ikke-invasiv temperaturovervågningsindretning |
JP4520198B2 (ja) | 2004-04-07 | 2010-08-04 | オリンパス株式会社 | 被検体内位置表示システム |
US20050234307A1 (en) | 2004-04-15 | 2005-10-20 | Nokia Corporation | Physiological event handling system and method |
US9801527B2 (en) | 2004-04-19 | 2017-10-31 | Gearbox, Llc | Lumen-traveling biological interface device |
US9011329B2 (en) | 2004-04-19 | 2015-04-21 | Searete Llc | Lumenally-active device |
JP2005304880A (ja) | 2004-04-23 | 2005-11-04 | Hitachi Ltd | 非接触icタグを利用した体内物体管理システム |
US8019471B2 (en) | 2004-04-24 | 2011-09-13 | Inrange Systems, Inc. | Integrated, non-sequential, remote medication management and compliance system |
US7196495B1 (en) | 2004-04-27 | 2007-03-27 | Concord Technologies, Lp | Dual battery and monitor arrangement |
US20050245794A1 (en) | 2004-04-29 | 2005-11-03 | Medtronic, Inc. | Communication with implantable monitoring probe |
GB0410248D0 (en) | 2004-05-07 | 2004-06-09 | Isis Innovation | Signal analysis method |
US20080051667A1 (en) | 2004-05-16 | 2008-02-28 | Rami Goldreich | Method And Device For Measuring Physiological Parameters At The Hand |
US20050261559A1 (en) | 2004-05-18 | 2005-11-24 | Mumford John R | Wireless physiological monitoring system |
US7575005B2 (en) | 2004-05-18 | 2009-08-18 | Excel-Tech Ltd. | Mask assembly with integrated sensors |
JP4459715B2 (ja) | 2004-05-20 | 2010-04-28 | 芝浦メカトロニクス株式会社 | 画像認識方法、画像認識装置及び実装装置 |
US7125382B2 (en) | 2004-05-20 | 2006-10-24 | Digital Angel Corporation | Embedded bio-sensor system |
JP2005332328A (ja) | 2004-05-21 | 2005-12-02 | Toyo Network Systems Co Ltd | 集計システム |
KR100592934B1 (ko) | 2004-05-21 | 2006-06-23 | 한국전자통신연구원 | 착용형 생체신호 검출모듈 및 이를 포함한 측정장치 |
US20050259768A1 (en) | 2004-05-21 | 2005-11-24 | Oki Techno Centre (Singapore) Pte Ltd | Digital receiver and method for processing received signals |
US7653542B2 (en) | 2004-05-26 | 2010-01-26 | Verizon Business Global Llc | Method and system for providing synthesized speech |
US20050267556A1 (en) | 2004-05-28 | 2005-12-01 | Allan Shuros | Drug eluting implants to prevent cardiac apoptosis |
BRPI0511604A (pt) | 2004-05-28 | 2008-01-02 | Jan De Geest | unidade de comunicação elétrica, sistema de comunicação elétrico, e, uso da unidade de comunicação elétrica ou do sistema de comunicação elétrico |
JP4666951B2 (ja) | 2004-06-03 | 2011-04-06 | シーケーディ株式会社 | ブリスタ包装機及び医薬品固形製剤 |
TWI428271B (zh) | 2004-06-09 | 2014-03-01 | Smithkline Beecham Corp | 生產藥物之裝置及方法 |
US7289855B2 (en) | 2004-06-09 | 2007-10-30 | Medtronic, Inc. | Implantable medical device package antenna |
WO2005123181A2 (en) | 2004-06-10 | 2005-12-29 | Ndi Medical, Llc | Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue |
JP2008502911A (ja) | 2004-06-12 | 2008-01-31 | アクバイオ・リミテッド | センサおよび較正要素のアレイを備えた分析機器 |
US7697994B2 (en) | 2004-06-18 | 2010-04-13 | Medtronic, Inc. | Remote scheduling for management of an implantable medical device |
JP2006003307A (ja) | 2004-06-21 | 2006-01-05 | Mitsutoyo Corp | エンコーダ、及び、その信号調整方法 |
US7460014B2 (en) | 2004-06-22 | 2008-12-02 | Vubiq Incorporated | RFID system utilizing parametric reflective technology |
JP2006006377A (ja) | 2004-06-22 | 2006-01-12 | Elquest Corp | 薬剤包装用の薬包紙 |
KR100615431B1 (ko) | 2004-06-22 | 2006-08-25 | 한국전자통신연구원 | 생체신호 검출모듈, 다채널 커넥터 모듈 및 이를 포함한생체신호 검출장치 |
US20050285746A1 (en) | 2004-06-25 | 2005-12-29 | Sengupta Uttam K | Radio frequency identification based system to track consumption of medication |
US7206630B1 (en) | 2004-06-29 | 2007-04-17 | Cleveland Medical Devices, Inc | Electrode patch and wireless physiological measurement system and method |
US20070027383A1 (en) | 2004-07-01 | 2007-02-01 | Peyser Thomas A | Patches, systems, and methods for non-invasive glucose measurement |
US20060001496A1 (en) | 2004-07-02 | 2006-01-05 | Abrosimov Igor A | Array oscillator and polyphase clock generator |
JP4462614B2 (ja) | 2004-07-05 | 2010-05-12 | ソニー・エリクソン・モバイルコミュニケーションズ株式会社 | 近距離無線通信システム、携帯端末装置および無線通信装置 |
US7505795B1 (en) * | 2004-07-07 | 2009-03-17 | Advanced Micro Devices, Inc. | Power save management with customized range for user configuration and tuning value based upon recent usage |
US7343186B2 (en) | 2004-07-07 | 2008-03-11 | Masimo Laboratories, Inc. | Multi-wavelength physiological monitor |
EP1781162A1 (en) | 2004-07-09 | 2007-05-09 | Tadiran Spectralink Ltd. | Wearable device, system and method for measuring vital parameters |
CN1314134C (zh) * | 2004-07-15 | 2007-05-02 | 上海交通大学 | 硅薄膜异质结太阳电池的制备方法 |
WO2006020363A2 (en) * | 2004-07-21 | 2006-02-23 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
WO2006008740A1 (en) | 2004-07-21 | 2006-01-26 | Aerotel Medical Systems (1998) Ltd. | Wearable device, system and method for measuring physiological and/or environmental parameters |
CN100459614C (zh) | 2004-07-22 | 2009-02-04 | 华为技术有限公司 | 一种手机外设装置与方法 |
US7537590B2 (en) | 2004-07-30 | 2009-05-26 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
WO2006062112A1 (ja) * | 2004-12-08 | 2006-06-15 | Seiko Instruments Inc. | 人体経由情報伝達システム及び送受信器 |
US7317378B2 (en) | 2004-08-17 | 2008-01-08 | Tagent Corporation | Product identification tag device and reader |
US20060058602A1 (en) | 2004-08-17 | 2006-03-16 | Kwiatkowski Krzysztof C | Interstitial fluid analyzer |
US7253716B2 (en) | 2004-08-17 | 2007-08-07 | Tagent Corporation | Trackable pills with electronic ID tags |
JP2008510558A (ja) | 2004-08-27 | 2008-04-10 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 少なくとも1つの薬剤を投与する、電子制御され、遠隔制御されるピル及びシステム |
WO2006026741A1 (en) | 2004-08-31 | 2006-03-09 | Lifescan Scotland Limited | Wearable sensor device and system |
EP1799101A4 (en) | 2004-09-02 | 2008-11-19 | Proteus Biomedical Inc | METHOD AND DEVICES FOR TISSUE ACTIVATION AND MONITORING |
KR100727817B1 (ko) * | 2004-09-07 | 2007-06-13 | 한국전자통신연구원 | 인체를 매질로 이용한 통신장치 및 그 방법 |
AU2005281502A1 (en) | 2004-09-08 | 2006-03-16 | Alertis Medical As | Sensor |
KR20060023228A (ko) * | 2004-09-09 | 2006-03-14 | 이기방 | 다공질물질을 가지는 배터리와 배터리제조방법 |
GB2418144A (en) | 2004-09-17 | 2006-03-22 | Psimedica Ltd | Medical device for delivery of beneficial substance |
US20060065713A1 (en) | 2004-09-24 | 2006-03-30 | John Russell Kingery | System and method for monitored administration of medical products to patients |
US7618374B2 (en) | 2004-09-27 | 2009-11-17 | Siemens Medical Solutions Usa, Inc. | Image plane sensing methods and systems for intra-patient probes |
JP5345319B2 (ja) | 2004-09-30 | 2013-11-20 | コーニンクレッカ フィリップス エヌ ヴェ | 無線医療デバイスの患者への関連付けのための自動的かつ連続的で信頼性のある患者識別システム |
US7554464B1 (en) | 2004-09-30 | 2009-06-30 | Gear Six, Inc. | Method and system for processing data having a pattern of repeating bits |
US7341560B2 (en) | 2004-10-05 | 2008-03-11 | Rader, Fishman & Grauer Pllc | Apparatuses and methods for non-invasively monitoring blood parameters |
US20060078765A1 (en) | 2004-10-12 | 2006-04-13 | Laixia Yang | Nano-structured ion-conducting inorganic membranes for fuel cell applications |
JP2008011865A (ja) | 2004-10-27 | 2008-01-24 | Sharp Corp | 健康管理装置及びこれを機能させるためのプログラム |
US7917199B2 (en) | 2004-11-02 | 2011-03-29 | Medtronic, Inc. | Patient event marking in combination with physiological signals |
WO2006050468A2 (en) | 2004-11-02 | 2006-05-11 | Medtronic, Inc. | Techniques for data reporting in an implantable medical device |
US20060095093A1 (en) | 2004-11-04 | 2006-05-04 | Ido Bettesh | Apparatus and method for receiving device selection and combining |
KR20060040500A (ko) | 2004-11-06 | 2006-05-10 | 삼성전자주식회사 | 생체신호 측정 장치 및 방법 |
US7414534B1 (en) * | 2004-11-09 | 2008-08-19 | Pacesetter, Inc. | Method and apparatus for monitoring ingestion of medications using an implantable medical device |
US7930064B2 (en) | 2004-11-19 | 2011-04-19 | Parata Systems, Llc | Automated drug discrimination during dispensing |
US7214107B2 (en) | 2004-11-22 | 2007-05-08 | Cardiodynamics International Corporation | Electrical connector apparatus and methods |
US8374693B2 (en) | 2004-12-03 | 2013-02-12 | Cardiac Pacemakers, Inc. | Systems and methods for timing-based communication between implantable medical devices |
US7154071B2 (en) | 2004-12-07 | 2006-12-26 | Dräger Safety AG & Co. KGaA | Device for transmitting an electric signal detected by contact with the skin surface |
US7616710B2 (en) * | 2004-12-08 | 2009-11-10 | Electronics And Telecommunications Research Institute | Frequency offset estimating method and receiver employing the same |
EP1827214B1 (en) | 2004-12-13 | 2012-02-15 | Koninklijke Philips Electronics N.V. | Mobile monitoring |
JP2008522778A (ja) | 2004-12-14 | 2008-07-03 | イー−ピル ファーマ リミティド | 電気透過性増加を用いた薬物又は物質の局所輸送 |
US20060136266A1 (en) | 2004-12-20 | 2006-06-22 | E-San Limited | Medicinal product order processing system |
JP4432766B2 (ja) | 2004-12-21 | 2010-03-17 | Jfeスチール株式会社 | 電気抵抗計測方法及びその装置 |
US7146449B2 (en) | 2004-12-22 | 2006-12-05 | International Business Machines Corporation | Bluetooth association with simple power connection |
US7249212B2 (en) | 2004-12-22 | 2007-07-24 | International Business Machines Corporation | Bluetooth association based on docking connection |
EP1676522B1 (en) | 2004-12-30 | 2008-07-02 | Given Imaging Ltd. | System for locating an in-vivo signal source |
KR20060077523A (ko) | 2004-12-30 | 2006-07-05 | 충북대학교 산학협력단 | 투약 조력 시스템 및 방법 |
US20060148254A1 (en) | 2005-01-05 | 2006-07-06 | Mclean George Y | Activated iridium oxide electrodes and methods for their fabrication |
ATE514440T1 (de) | 2005-01-17 | 2011-07-15 | Novo Nordisk As | Flüssigkeitsausgabevorrichtung mit integrierter überwachung von physiologischen eigenschaften |
WO2006077528A2 (en) * | 2005-01-18 | 2006-07-27 | Koninklijke Philips Electronics, N.V. | Electronically controlled capsule |
CN101208039A (zh) * | 2005-01-18 | 2008-06-25 | 皇家飞利浦电子股份有限公司 | 用于对消化道中的流体采样的可摄入电控胶囊 |
CN101107043A (zh) * | 2005-01-18 | 2008-01-16 | 皇家飞利浦电子股份有限公司 | 用于释放辐射的电控胶囊 |
EP1861158A2 (en) * | 2005-01-18 | 2007-12-05 | Koninklijke Philips Electronics N.V. | System for controlling traversal of an ingested capsule |
US7686839B2 (en) | 2005-01-26 | 2010-03-30 | Lumitex, Inc. | Phototherapy treatment devices for applying area lighting to a wound |
JP4731936B2 (ja) * | 2005-02-09 | 2011-07-27 | 本田技研工業株式会社 | 回転式可変抵抗器 |
JP4099484B2 (ja) | 2005-02-09 | 2008-06-11 | 株式会社カイザーテクノロジー | 通信システム。 |
US7850645B2 (en) | 2005-02-11 | 2010-12-14 | Boston Scientific Scimed, Inc. | Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power |
JP2008529631A (ja) | 2005-02-11 | 2008-08-07 | ザ ユニバーシティー コート オブ ザ ユニバーシティー オブ グラスゴー | 検査デバイス、検査装置及び検査システム、並びにそれらの駆動方法 |
DE102005007790B4 (de) | 2005-02-19 | 2007-06-28 | Fette Gmbh | Verfahren und Vorrichtung zur Versuchspressung von Mehrschichttabletten oder Manteltabletten |
KR20060097523A (ko) | 2005-03-10 | 2006-09-14 | 강성철 | 리드와이어의 자동 탈피 및 도금장치 |
US7504954B2 (en) | 2005-03-17 | 2009-03-17 | Spaeder Jeffrey A | Radio frequency identification pharmaceutical tracking system and method |
EP1863559A4 (en) | 2005-03-21 | 2008-07-30 | Abbott Diabetes Care Inc | METHOD AND SYSTEM FOR PROVIDING AN INTEGRATED MEDICINE INFUSION SYSTEM AND ANALYTICAL MONITORING SYSTEM |
JP5011275B2 (ja) | 2005-03-22 | 2012-08-29 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 高性能な無線医療センサネットワークに対するアドレッシング・スキーム |
US20060252999A1 (en) | 2005-05-03 | 2006-11-09 | Devaul Richard W | Method and system for wearable vital signs and physiology, activity, and environmental monitoring |
US20060216603A1 (en) | 2005-03-26 | 2006-09-28 | Enable Ipc | Lithium-ion rechargeable battery based on nanostructures |
JP2006278091A (ja) | 2005-03-29 | 2006-10-12 | Hitachi Maxell Ltd | コイン形酸化銀電池 |
US20060224326A1 (en) | 2005-03-31 | 2006-10-05 | St Ores John W | Integrated data collection and analysis for clinical study |
GB0506925D0 (en) | 2005-04-06 | 2005-05-11 | Zarlink Semiconductor Ab | Ultra low power wake-up solution for implantable RF telemetry devices |
EP1893282A1 (en) | 2005-04-07 | 2008-03-05 | St. Jude Medical AB | System and method for radio communication between an implantable medical device and an external base unit |
US7760104B2 (en) | 2005-04-08 | 2010-07-20 | Entegris, Inc. | Identification tag for fluid containment drum |
AU2006235722A1 (en) | 2005-04-14 | 2006-10-19 | Hidalgo Limited | Apparatus and system for monitoring |
US7270633B1 (en) | 2005-04-22 | 2007-09-18 | Cardiac Pacemakers, Inc. | Ambulatory repeater for use in automated patient care and method thereof |
US8730031B2 (en) | 2005-04-28 | 2014-05-20 | Proteus Digital Health, Inc. | Communication system using an implantable device |
EP2392258B1 (en) | 2005-04-28 | 2014-10-08 | Proteus Digital Health, Inc. | Pharma-informatics system |
US20060247505A1 (en) | 2005-04-28 | 2006-11-02 | Siddiqui Waqaas A | Wireless sensor system |
US8836513B2 (en) | 2006-04-28 | 2014-09-16 | Proteus Digital Health, Inc. | Communication system incorporated in an ingestible product |
US8912908B2 (en) * | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
US20120004520A1 (en) | 2005-04-28 | 2012-01-05 | Proteus Biomedical, Inc. | Communication System with Multiple Sources of Power |
US7881799B2 (en) | 2005-04-28 | 2011-02-01 | Second Sight Medical Products, Inc. | Retinal prosthesis and method of manufacturing a retinal prosthesis |
US9198608B2 (en) | 2005-04-28 | 2015-12-01 | Proteus Digital Health, Inc. | Communication system incorporated in a container |
US20120024889A1 (en) * | 2005-04-28 | 2012-02-02 | Timothy Robertson | Polypharmacy Co-Packaged Medication Dosing Unit Including Communication System Therefor |
US7414543B2 (en) | 2005-04-28 | 2008-08-19 | Honeywell International Inc. | Multiple miniature avionic displays |
US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US7359674B2 (en) | 2005-05-10 | 2008-04-15 | Nokia Corporation | Content distribution & communication system for enhancing service distribution in short range radio environment |
US20060255064A1 (en) | 2005-05-10 | 2006-11-16 | Par Technologies, Llc | Fluid container with integrated valve |
CA2606941C (en) | 2005-05-10 | 2015-06-23 | Cardinal Health 303, Inc. | Medication safety system featuring a multiplexed rfid interrogator panel |
US20060262181A1 (en) | 2005-05-17 | 2006-11-23 | Robbins Gene A | Laser-based image former operable to form dynamically variable images in objects in single shot events |
WO2006127355A2 (en) | 2005-05-20 | 2006-11-30 | Dow Global Technologies Inc. | Oral drug compliance monitoring using radio frequency identification tags |
US8082919B2 (en) | 2005-05-24 | 2011-12-27 | Shl Group Ab | Dose counter device for inhaler |
US8285205B2 (en) | 2005-05-26 | 2012-10-09 | Broadcom Corporation | Method and system for a single chip integrated Bluetooth and FM transceiver and baseband processor |
US20060273882A1 (en) | 2005-06-01 | 2006-12-07 | Intel Corporation | RFID tag with separate transmit and receive clocks and related method |
US20060276702A1 (en) | 2005-06-03 | 2006-12-07 | Mcginnis William | Neurophysiological wireless bio-sensor |
US7387607B2 (en) | 2005-06-06 | 2008-06-17 | Intel Corporation | Wireless medical sensor system |
KR100695152B1 (ko) * | 2005-06-07 | 2007-03-14 | 삼성전자주식회사 | 심전도 측정용 전극 및 그를 포함하는 심전도 측정 장치 |
WO2006133444A2 (en) | 2005-06-09 | 2006-12-14 | Medtronic, Inc. | Implantable medical device with electrodes on multiple housing surfaces |
US20060282001A1 (en) | 2005-06-09 | 2006-12-14 | Michel Noel | Physiologic sensor apparatus |
WO2006130988A1 (en) | 2005-06-10 | 2006-12-14 | Telecommunications Research Laboratories | Wireless communication system |
ITTO20050407A1 (it) | 2005-06-13 | 2006-12-14 | Ist Superiore Mario Boella | Sistema di monitoraggio remoto di parametri fisiologici di un individuo, procedimento e prodotto informatico |
JP2006346000A (ja) | 2005-06-14 | 2006-12-28 | Aruze Corp | 遊技機、サーバ |
US7616111B2 (en) | 2005-06-20 | 2009-11-10 | Carestream Health, Inc. | System to monitor the ingestion of medicines |
US7782189B2 (en) | 2005-06-20 | 2010-08-24 | Carestream Health, Inc. | System to monitor the ingestion of medicines |
US7299034B2 (en) | 2005-06-21 | 2007-11-20 | Lawrence Kates | System and method for wearable electronics |
US20080262320A1 (en) | 2005-06-28 | 2008-10-23 | Schaefer Timothy M | System for Monitoring a Physical Parameter of a Subject |
FI20055366A0 (fi) | 2005-06-30 | 2005-06-30 | Gen Electric | Elektrodi biopotentiaalisignaalin saamiseksi |
JP4120969B2 (ja) | 2005-07-04 | 2008-07-16 | 独立行政法人 宇宙航空研究開発機構 | 超音波試験方法及びこれを用いた超音波試験装置 |
EP1900089B1 (en) | 2005-07-06 | 2018-06-06 | Liebert Corporation | Maximized battery run-time in a parallel ups system |
US20070016089A1 (en) | 2005-07-15 | 2007-01-18 | Fischell David R | Implantable device for vital signs monitoring |
WO2007013952A2 (en) | 2005-07-20 | 2007-02-01 | Euliano Neil R | Medication compliance system and associated methods |
EP1909765A1 (en) | 2005-07-22 | 2008-04-16 | Dow Gloval Technologies Inc. | Oral drug compliance monitoring using sound detection |
CN100471445C (zh) | 2005-08-01 | 2009-03-25 | 周常安 | 贴片式生理监测装置 |
US20070029195A1 (en) | 2005-08-03 | 2007-02-08 | Changming Li | Polymer/nanoparticle composites, film and molecular detection device |
US20090142853A1 (en) * | 2005-08-11 | 2009-06-04 | Eksigent Technologies, Llc | Microfluidic system and methods |
WO2007021496A2 (en) | 2005-08-18 | 2007-02-22 | Walker Digital, Llc | Systems and methods for improved health care compliance |
US20090124871A1 (en) | 2005-08-22 | 2009-05-14 | Khalil Arshak | Tracking system |
US8116809B2 (en) | 2005-08-29 | 2012-02-14 | Intel Corporation | Method and apparatus of multiple entity wireless communication adapter |
US8827904B2 (en) | 2005-08-31 | 2014-09-09 | Medtronic, Inc. | Automatic parameter status on an implantable medical device system |
WO2007028035A2 (en) | 2005-09-01 | 2007-03-08 | Proteus Biomedical, Inc. | Implantable zero-wire communications system |
JP2007068622A (ja) * | 2005-09-05 | 2007-03-22 | Olympus Corp | 被検体内情報取得システム |
US20070135803A1 (en) | 2005-09-14 | 2007-06-14 | Amir Belson | Methods and apparatus for performing transluminal and other procedures |
WO2007031973A2 (en) | 2005-09-15 | 2007-03-22 | Visible Assets, Inc. | Active low frequency radio tag and patch drug delivery system |
US7673679B2 (en) | 2005-09-19 | 2010-03-09 | Schlumberger Technology Corporation | Protective barriers for small devices |
US20080058614A1 (en) | 2005-09-20 | 2008-03-06 | Triage Wireless, Inc. | Wireless, internet-based system for measuring vital signs from a plurality of patients in a hospital or medical clinic |
GB0519837D0 (en) | 2005-09-29 | 2005-11-09 | Smartlife Technology Ltd | Knitting techniques |
GB0519836D0 (en) | 2005-09-29 | 2005-11-09 | Smartlife Technology Ltd | Contact sensors |
GB0519945D0 (en) | 2005-09-30 | 2005-11-09 | Cambridge Silicon Radio Ltd | Communication in dual protocol environments |
US20070078324A1 (en) | 2005-09-30 | 2007-04-05 | Textronics, Inc. | Physiological Monitoring Wearable Having Three Electrodes |
CN100466966C (zh) | 2005-10-08 | 2009-03-11 | 周常安 | 呼吸气流生理信号提取和监测装置及系统 |
US7733224B2 (en) | 2006-06-30 | 2010-06-08 | Bao Tran | Mesh network personal emergency response appliance |
US9154616B2 (en) | 2005-10-18 | 2015-10-06 | Oia Intellectuals, Inc. | Wearable capture and communication |
US7720036B2 (en) | 2005-10-26 | 2010-05-18 | Intel Corporation | Communication within a wireless network using multiple frequency bands |
US7499739B2 (en) | 2005-10-27 | 2009-03-03 | Smiths Medical Pm, Inc. | Single use pulse oximeter |
US8515348B2 (en) | 2005-10-28 | 2013-08-20 | Electro Industries/Gauge Tech | Bluetooth-enable intelligent electronic device |
CN103110948A (zh) | 2005-11-04 | 2013-05-22 | 惠氏公司 | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 |
US9067047B2 (en) | 2005-11-09 | 2015-06-30 | The Invention Science Fund I, Llc | Injectable controlled release fluid delivery system |
WO2007053949A1 (en) * | 2005-11-12 | 2007-05-18 | Nortel Networks Limited | System and method for unbalanced relay-based wireless communications |
GB0523447D0 (en) | 2005-11-17 | 2005-12-28 | E San Ltd | System and method for communicating environmentally-based medical support advice |
EP1956973B1 (en) | 2005-11-30 | 2017-09-13 | Koninklijke Philips N.V. | Electro-mechanical connector for thin medical monitoring patch |
US7456329B2 (en) | 2005-11-30 | 2008-11-25 | Exxonmobil Chemical Patents Inc. | Polyolefins from non-conventional feeds |
US8016776B2 (en) | 2005-12-02 | 2011-09-13 | Medtronic, Inc. | Wearable ambulatory data recorder |
KR101258424B1 (ko) * | 2005-12-02 | 2013-04-26 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 디바이스 |
US8295932B2 (en) * | 2005-12-05 | 2012-10-23 | Metacure Limited | Ingestible capsule for appetite regulation |
NL1030608C2 (nl) | 2005-12-06 | 2007-06-07 | Patrick Antonius Hendri Meeren | Blisterverpakking, samenstel van een blisterverpakking en een houder, alsmede werkwijze voor het verpakken van objecten. |
US20070135691A1 (en) | 2005-12-12 | 2007-06-14 | General Electric Company | Medicament compliance monitoring system, method, and medicament container |
CN1985752A (zh) | 2005-12-19 | 2007-06-27 | 周常安 | 分布式生理信号监测设备 |
US20090047357A1 (en) | 2005-12-22 | 2009-02-19 | Otsuka Pharmaceutical Co., Ltd. | Method of producing drug-containing wax matrix particles, extruder to be used in the method and sustained-release preparation containing cilostazol |
US20070156016A1 (en) | 2005-12-29 | 2007-07-05 | Ido Betesh | Method and system for communication with an ingestible imaging device |
US7678043B2 (en) | 2005-12-29 | 2010-03-16 | Given Imaging, Ltd. | Device, system and method for in-vivo sensing of a body lumen |
DE602006018529D1 (de) * | 2005-12-29 | 2011-01-05 | Osmotica Kereskedelmi Es Szolgaltato Kft | Mehrschichtige tablette mit dreifacher freisetzungskombination |
TWI306023B (en) | 2005-12-30 | 2009-02-11 | Ind Tech Res Inst | Monitoring apparatus for physical movements of a body organ and method for acouiring the same |
US7492128B2 (en) | 2005-12-30 | 2009-02-17 | Flexmedia Electronics Corp. | Dynamic distribution device for battery power loop |
US8301254B2 (en) | 2006-01-09 | 2012-10-30 | Greatbatch Ltd. | Cross-band communications in an implantable device |
US20070162089A1 (en) | 2006-01-09 | 2007-07-12 | Transoma Medical, Inc. | Cross-band communications in an implantable device |
US8078278B2 (en) | 2006-01-10 | 2011-12-13 | Remon Medical Technologies Ltd. | Body attachable unit in wireless communication with implantable devices |
CN100571239C (zh) | 2006-01-16 | 2009-12-16 | 华为技术有限公司 | 通信系统中的同步导频序列生成系统和方法 |
ES2707474T3 (es) | 2006-01-18 | 2019-04-03 | Intec Pharma Ltd | Dispositivo de suministro para la vía oral de un agente |
US20100228113A1 (en) | 2006-01-23 | 2010-09-09 | Koninklijke Philips Electronics N.V. | Improved biomedical electrode for extended patient wear featuring a tap, or snap, which is isolated from the retentional seal |
JP2007200739A (ja) | 2006-01-27 | 2007-08-09 | Keio Gijuku | 体内飲み込み型発電池 |
US20070185393A1 (en) | 2006-02-03 | 2007-08-09 | Triage Wireless, Inc. | System for measuring vital signs using an optical module featuring a green light source |
US7809399B2 (en) | 2006-02-10 | 2010-10-05 | Syntek International Holding Ltd. | Method and device for providing multiple communication protocols with a single transceiver |
US20100049006A1 (en) | 2006-02-24 | 2010-02-25 | Surendar Magar | Medical signal processing system with distributed wireless sensors |
CN101389265B (zh) | 2006-02-24 | 2011-01-26 | 皇家飞利浦电子股份有限公司 | 无线身体传感器网络 |
JP2009528909A (ja) | 2006-03-03 | 2009-08-13 | フィジオウェイヴ インコーポレイテッド | 生理学的モニタリングシステム及び方法 |
US8200320B2 (en) | 2006-03-03 | 2012-06-12 | PhysioWave, Inc. | Integrated physiologic monitoring systems and methods |
JP2007241928A (ja) | 2006-03-13 | 2007-09-20 | Asahi Seiko Kk | コインホッパのコイン残量検知装置 |
WO2007104152A2 (en) | 2006-03-14 | 2007-09-20 | Jamie Hackett | Long-range radio frequency receiver-controller module and wireless control system comprising same |
US8131376B1 (en) | 2007-09-11 | 2012-03-06 | Second Sight Medical Products, Inc. | Method of inspection of materials for defects |
US8920343B2 (en) | 2006-03-23 | 2014-12-30 | Michael Edward Sabatino | Apparatus for acquiring and processing of physiological auditory signals |
AU2007231510A1 (en) | 2006-03-29 | 2007-10-04 | Electronic Dietary Foods Inc. | Ingestible implement for weight control |
CN102323984A (zh) | 2006-03-30 | 2012-01-18 | 陶氏环球技术有限责任公司 | 用于监控并分析体内用药方案的依从的方法与系统 |
DE102006017196B4 (de) | 2006-04-12 | 2008-09-11 | Fette Gmbh | Verfahren zur Regelung der Wirkstoffmenge von Tabletten während der Produktion in einer Rundläufertablettenpresse |
TW200738212A (en) | 2006-04-12 | 2007-10-16 | Guo Terry Bo Jau | Miniature wireless apparatus for collecting physiological signals of animals |
CA2649447A1 (en) | 2006-04-25 | 2007-11-08 | Dow Global Technologies Inc. | Oral drug compliance monitoring using magnetic-field sensors |
US7912537B2 (en) | 2006-04-27 | 2011-03-22 | Medtronic, Inc. | Telemetry-synchronized physiological monitoring and therapy delivery systems |
MY187399A (en) | 2006-04-28 | 2021-09-22 | Qualcomm Inc | Method and apparatus for enhanced paging |
US7942844B2 (en) | 2006-04-28 | 2011-05-17 | Medtronic Minimed, Inc. | Remote monitoring for networked fluid infusion systems |
CN105468895A (zh) | 2006-05-02 | 2016-04-06 | 普罗透斯数字保健公司 | 患者定制的治疗方案 |
GB0608829D0 (en) | 2006-05-04 | 2006-06-14 | Husheer Shamus L G | In-situ measurement of physical parameters |
WO2007128165A1 (fr) | 2006-05-09 | 2007-11-15 | Fangen Xiong | Systèmes de réseaux sans fil courte portée et procédé de montage consistant à attribuer des créneaux temporels avec un émetteur-récepteur rf multivoie |
CN101444131B (zh) | 2006-05-10 | 2012-04-18 | 交互数字技术公司 | 在聚合无线发射/接收单元中用于电源管理的方法和设备 |
US20080051647A1 (en) | 2006-05-11 | 2008-02-28 | Changwang Wu | Non-invasive acquisition of large nerve action potentials (NAPs) with closely spaced surface electrodes and reduced stimulus artifacts |
US7558622B2 (en) | 2006-05-24 | 2009-07-07 | Bao Tran | Mesh network stroke monitoring appliance |
WO2007132282A1 (en) | 2006-05-15 | 2007-11-22 | Nokia Corporation | Contactless programming and testing of memory elements |
US7539533B2 (en) | 2006-05-16 | 2009-05-26 | Bao Tran | Mesh network monitoring appliance |
US20080077015A1 (en) | 2006-05-17 | 2008-03-27 | Olga Boric-Lubecke | Determining presence and/or physiological motion of one or more subjects with multiple receiver Doppler radar systems |
CN101073494B (zh) | 2006-05-18 | 2010-09-08 | 周常安 | 非侵入式生命迹象监测设备、系统及方法 |
JP2009537281A (ja) | 2006-05-19 | 2009-10-29 | シーブイレクス インコーポレイテッド | 圧反射活性化と薬物治療を併用した生理反応の特性解析および調節 |
US20070279217A1 (en) | 2006-06-01 | 2007-12-06 | H-Micro, Inc. | Integrated mobile healthcare system for cardiac care |
US8562526B2 (en) | 2006-06-01 | 2013-10-22 | Resmed Sensor Technologies Limited | Apparatus, system, and method for monitoring physiological signs |
FI120482B (fi) | 2006-06-08 | 2009-11-13 | Suunto Oy | Anturointijärjestely |
US7346380B2 (en) | 2006-06-16 | 2008-03-18 | Axelgaard Manufacturing Co., Ltd. | Medical electrode |
US20100143232A1 (en) | 2006-06-21 | 2010-06-10 | Benedict James Costello | Metal binary and ternary compounds produced by cathodic arc deposition |
WO2008076464A2 (en) | 2006-06-21 | 2008-06-26 | Surgisense Corporation | Wireless medical telemetry system and methods using radio-frequency energized biosensors |
EP2046434B1 (en) | 2006-06-23 | 2012-02-08 | Koninklijke Philips Electronics N.V. | Medicament delivery system |
US20080046038A1 (en) | 2006-06-26 | 2008-02-21 | Hill Gerard J | Local communications network for distributed sensing and therapy in biomedical applications |
US7949404B2 (en) | 2006-06-26 | 2011-05-24 | Medtronic, Inc. | Communications network for distributed sensing and therapy in biomedical applications |
US20080000804A1 (en) | 2006-06-29 | 2008-01-03 | Carey David A | Carrier tape with integrated cover tape |
US8165896B2 (en) | 2006-06-29 | 2012-04-24 | The Invention Science Fund I, Llc | Compliance data for health-related procedures |
DE502006003608D1 (de) | 2006-06-29 | 2009-06-10 | Edwin Kohl | Personalisierte Blisterpackung und Verfahren zur automatischen Verpackung einer individuell festgelegten Produktzusammenstellung |
IL176712A0 (en) | 2006-07-05 | 2007-10-31 | Michael Cohen Alloro | Medication dispenser |
JP5241714B2 (ja) | 2006-07-07 | 2013-07-17 | プロテウス デジタル ヘルス, インコーポレイテッド | スマートな非経口送達システム |
US20080020037A1 (en) * | 2006-07-11 | 2008-01-24 | Robertson Timothy L | Acoustic Pharma-Informatics System |
WO2008008845A2 (en) | 2006-07-11 | 2008-01-17 | Microchips, Inc. | Multi-reservoir pump device for dialysis, biosensing, or delivery of substances |
US7962174B2 (en) | 2006-07-12 | 2011-06-14 | Andrew Llc | Transceiver architecture and method for wireless base-stations |
US20080021521A1 (en) | 2006-07-18 | 2008-01-24 | Cardiac Pacemakers, Inc. | Implantable Medical Device Communication System |
DE102007020583B4 (de) | 2006-07-19 | 2012-10-11 | Erbe Elektromedizin Gmbh | Elektrodeneinrichtung mit einerImnpedanz-Messeinrichtung und Verfahren zum Herstellen einer derartigen Elektrodeneinrichtung |
US20090318761A1 (en) | 2006-08-10 | 2009-12-24 | Elisha Rabinovitz | System and method for in vivo imaging |
AU2007284422B2 (en) | 2006-08-18 | 2011-06-02 | Second Sight Medical Products, Inc. | Package for an implantable neural stimulation device |
US20080097549A1 (en) | 2006-09-01 | 2008-04-24 | Colbaugh Michael E | Electrode Assembly and Method of Using Same |
US8172762B2 (en) * | 2006-09-01 | 2012-05-08 | Proteus Biomedical, Inc. | Simultaneous blood flow and hematocrit sensor |
TW200832140A (en) | 2006-09-01 | 2008-08-01 | Fairchild Semiconductor | Low power serdes architecture using serial I/O burst gating |
US7756573B2 (en) | 2006-09-05 | 2010-07-13 | Cardiac Pacemakers, Inc. | Implantable medical device diagnostic data acquisition and storage |
WO2008030480A2 (en) * | 2006-09-06 | 2008-03-13 | Innurvation, Inc. | Ingestible low power sensor device and system for communicating with same |
US8615284B2 (en) | 2006-09-06 | 2013-12-24 | Innurvation, Inc. | Method for acoustic information exchange involving an ingestible low power capsule |
US20090273467A1 (en) | 2006-09-18 | 2009-11-05 | Koninklijke Philips Electronics N. V. | Ip based monitoring and alarming |
US20080077184A1 (en) | 2006-09-27 | 2008-03-27 | Stephen Denker | Intravascular Stimulation System With Wireless Power Supply |
US20080077028A1 (en) | 2006-09-27 | 2008-03-27 | Biotronic Crm Patent | Personal health monitoring and care system |
CN101522094B (zh) | 2006-09-29 | 2013-12-18 | 皇家飞利浦电子股份有限公司 | 微型化阈值传感器 |
US20080091114A1 (en) | 2006-10-11 | 2008-04-17 | Pacesetter, Inc. | Techniques for Correlating Thoracic Impedance with Physiological Status |
US20080091089A1 (en) * | 2006-10-12 | 2008-04-17 | Kenneth Shane Guillory | Single use, self-contained surface physiological monitor |
WO2008066617A2 (en) | 2006-10-17 | 2008-06-05 | Proteus Biomedical, Inc. | Low voltage oscillator for medical devices |
US8054047B2 (en) | 2006-10-18 | 2011-11-08 | Hewlett-Packard Development Company, L.P. | Battery pack charging system and method |
US20080097917A1 (en) | 2006-10-24 | 2008-04-24 | Kent Dicks | Systems and methods for wireless processing and medical device monitoring via remote command execution |
EP2083680B1 (en) | 2006-10-25 | 2016-08-10 | Proteus Digital Health, Inc. | Controlled activation ingestible identifier |
US8214007B2 (en) | 2006-11-01 | 2012-07-03 | Welch Allyn, Inc. | Body worn physiological sensor device having a disposable electrode module |
JP5681844B2 (ja) | 2006-11-14 | 2015-03-11 | シーエフピーエイチ, エル.エル.シー. | 賭け型ゲームのための方法及び装置 |
US20080119705A1 (en) | 2006-11-17 | 2008-05-22 | Medtronic Minimed, Inc. | Systems and Methods for Diabetes Management Using Consumer Electronic Devices |
EP2069004A4 (en) | 2006-11-20 | 2014-07-09 | Proteus Digital Health Inc | PERSONAL HEALTH SIGNAL RECEIVERS WITH ACTIVE SIGNAL PROCESSING |
JP5830222B2 (ja) | 2006-11-21 | 2015-12-09 | メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ | 摂取可能な電子カプセル、及び、生体内薬剤運搬又は診断システム |
GB0624085D0 (en) | 2006-12-01 | 2007-01-10 | Oxford Biosignals Ltd | Biomedical signal analysis method |
GB0624081D0 (en) | 2006-12-01 | 2007-01-10 | Oxford Biosignals Ltd | Biomedical signal analysis method |
US8180425B2 (en) | 2006-12-05 | 2012-05-15 | Tyco Healthcare Group Lp | ECG lead wire organizer and dispenser |
US20080137566A1 (en) | 2006-12-06 | 2008-06-12 | Bojko Marholev | Method and System for Shared High-Power Transmit Path for a Multi-Protocol Transceiver |
BRPI0720148B8 (pt) | 2006-12-07 | 2021-06-22 | Koninklijke Philips Electronics Nv | dispositivo de monitoração de eletrocardiograma, e, método para obter dados de ecg de um indivíduo |
US20080146889A1 (en) | 2006-12-13 | 2008-06-19 | National Yang-Ming University | Method of monitoring human physiological parameters and safty conditions universally |
US8157730B2 (en) | 2006-12-19 | 2012-04-17 | Valencell, Inc. | Physiological and environmental monitoring systems and methods |
TWI334747B (en) * | 2006-12-22 | 2010-12-11 | Unimicron Technology Corp | Circuit board structure having embedded electronic components |
US7782991B2 (en) | 2007-01-09 | 2010-08-24 | Freescale Semiconductor, Inc. | Fractionally related multirate signal processor and method |
AU2007342218A1 (en) | 2007-01-10 | 2008-07-17 | Camillo Ricordi | Mobile emergency alert system |
CN101663014A (zh) | 2007-01-16 | 2010-03-03 | 陶氏环球技术公司 | 整合通信装置的口服药物胶囊组件 |
EP2125075A2 (en) * | 2007-01-22 | 2009-12-02 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
US20080294020A1 (en) | 2007-01-25 | 2008-11-27 | Demetrios Sapounas | System and method for physlological data readings, transmission and presentation |
US20080183245A1 (en) | 2007-01-31 | 2008-07-31 | Van Oort Geeske | Telemetry of external physiological sensor data and implantable medical device data to a central processing system |
MY165532A (en) | 2007-02-01 | 2018-04-02 | Proteus Digital Health Inc | Ingestible event marker systems |
US20080214985A1 (en) | 2007-02-02 | 2008-09-04 | Activatek, Inc. | Active transdermal medicament patch |
WO2008097652A2 (en) | 2007-02-08 | 2008-08-14 | Senior Vitals, Inc. | Body patch for none-invasive physiological data readings |
CA2676280C (en) | 2007-02-14 | 2018-05-22 | Proteus Biomedical, Inc. | In-body power source having high surface area electrode |
US9270025B2 (en) | 2007-03-09 | 2016-02-23 | Proteus Digital Health, Inc. | In-body device having deployable antenna |
EP2124725A1 (en) | 2007-03-09 | 2009-12-02 | Proteus Biomedical, Inc. | In-body device having a multi-directional transmitter |
WO2008115722A1 (en) | 2007-03-16 | 2008-09-25 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Security for blister packs |
US20080303638A1 (en) | 2007-03-24 | 2008-12-11 | Hap Nguyen | Portable patient devices, systems, and methods for providing patient aid and preventing medical errors, for monitoring patient use of ingestible medications, and for preventing distribution of counterfeit drugs |
WO2008120128A2 (en) | 2007-03-30 | 2008-10-09 | Koninklijke Philips Electronics N.V. | System and method for pill communication and control |
JP4920478B2 (ja) | 2007-04-05 | 2012-04-18 | 株式会社東芝 | Mri装置 |
US7998110B2 (en) | 2007-04-25 | 2011-08-16 | Hong Kong Polytechnic University | Medical device for delivering drug and/or performing physical therapy |
KR100895297B1 (ko) | 2007-04-30 | 2009-05-07 | 한국전자통신연구원 | 다양한 생체 신호의 동시 측정을 위한 다채널 전극센서장치 |
US20100256461A1 (en) | 2007-05-01 | 2010-10-07 | Urodynamix Technologies Ltd. | Apparatus and methods for evaluating physiological conditions of tissue |
GB0709248D0 (en) | 2007-05-14 | 2007-06-20 | T & Medical Ltd | System for monitoring chemotherapy associated adverse drug reactions |
US8412293B2 (en) | 2007-07-16 | 2013-04-02 | Optiscan Biomedical Corporation | Systems and methods for determining physiological parameters using measured analyte values |
US8540632B2 (en) * | 2007-05-24 | 2013-09-24 | Proteus Digital Health, Inc. | Low profile antenna for in body device |
US7946101B1 (en) | 2007-05-30 | 2011-05-24 | Walgreen Co. | Method and system for verification of contents of a multi-cell, multi-product blister pack |
US20080300572A1 (en) | 2007-06-01 | 2008-12-04 | Medtronic Minimed, Inc. | Wireless monitor for a personal medical device system |
US20080311852A1 (en) | 2007-06-15 | 2008-12-18 | Broadcom Corporation | Multiple communication link coordination for shared data transmissions |
US8060175B2 (en) | 2007-06-15 | 2011-11-15 | General Electric Company | System and apparatus for collecting physiological signals from a plurality of electrodes |
EP2008584A1 (en) | 2007-06-26 | 2008-12-31 | Julius-Maximilians-Universität Würzburg | In vivo device, system and usage thereof |
GB2450517A (en) | 2007-06-27 | 2008-12-31 | Smartlife Technology Ltd | Electrical resistance of yarn or fabric changes with temperature |
CN201076456Y (zh) | 2007-06-29 | 2008-06-25 | 洪金叶 | 夹挂式无线传输心跳侦测装置 |
US8404275B2 (en) | 2007-07-01 | 2013-03-26 | Vitalis Llc | Combination tablet with chewable outer layer |
US20090009332A1 (en) * | 2007-07-03 | 2009-01-08 | Endotronix, Inc. | System and method for monitoring ingested medication via rf wireless telemetry |
JP5065780B2 (ja) | 2007-07-03 | 2012-11-07 | 株式会社日立製作所 | Rfidタグ実装基板 |
JP4520491B2 (ja) | 2007-07-09 | 2010-08-04 | オリンパス株式会社 | カプセル型医療システム |
US8340750B2 (en) | 2007-07-19 | 2012-12-25 | Medtronic, Inc. | Mechanical function marker channel for cardiac monitoring and therapy control |
US9592377B2 (en) | 2007-07-27 | 2017-03-14 | Second Sight Medical Products, Inc. | Implantable device for the brain |
GB0714807D0 (en) | 2007-07-30 | 2007-09-12 | Oxford Biosignals Ltd | Method and apparatus for measuring breathing rate |
KR100863064B1 (ko) | 2007-08-03 | 2008-10-13 | 한국전자통신연구원 | 생체 신호 측정용 의복 및 그 제조 방법 |
KR101080423B1 (ko) | 2007-08-03 | 2011-11-04 | 삼성전자주식회사 | 멀티모듈결합형 휴대전자장치 |
US9179864B2 (en) | 2007-08-15 | 2015-11-10 | Integrity Tracking, Llc | Wearable health monitoring device and methods for fall detection |
US20090048498A1 (en) | 2007-08-17 | 2009-02-19 | Frank Riskey | System and method of monitoring an animal |
US8926509B2 (en) | 2007-08-24 | 2015-01-06 | Hmicro, Inc. | Wireless physiological sensor patches and systems |
US20090062670A1 (en) | 2007-08-30 | 2009-03-05 | Gary James Sterling | Heart monitoring body patch and system |
WO2009029899A1 (en) | 2007-09-01 | 2009-03-05 | Sang Hoon Woo | Controlling body fluid condition using diuretics |
US20110160549A1 (en) | 2007-09-05 | 2011-06-30 | Saroka Amir | Method, system and apparatus for using electromagnetic radiation for monitoring a tissue of a user |
CN101827555B (zh) | 2007-09-07 | 2012-11-21 | 英戈·弗洛尔 | 诊断用传感器单元 |
JP2009061236A (ja) | 2007-09-07 | 2009-03-26 | Arimasa Nishida | 個人の医療情報のマルチデータ読み込み・入力機能、データ管理・解析・表示機能、健康自己管理を促すエンターテインメント・ゲーム機能と通信機能を備えた、生活習慣病についての強力なバイオフィードバック効果を持つ小型端末で、さらに医療機関、自治体あるいは国家レベルでの医療情報のデータベース化の際に、最初に個人の測定データを統一管理できる、小型端末。 |
US20090069642A1 (en) | 2007-09-11 | 2009-03-12 | Aid Networks, Llc | Wearable Wireless Electronic Patient Data Communications and Physiological Monitoring Device |
WO2009036334A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent multi-sensor device with empathic monitoring |
WO2009036313A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent device with multiple physiological sensors |
WO2009036306A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent cardiac monitor with advanced sensing capabilities |
US20090076343A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Energy Management for Adherent Patient Monitor |
US20090076349A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent Multi-Sensor Device with Implantable Device Communication Capabilities |
US20090076397A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent Emergency Patient Monitor |
EP2200512A1 (en) | 2007-09-14 | 2010-06-30 | Corventis, Inc. | Adherent device for respiratory monitoring and sleep disordered breathing |
DK2192946T3 (da) | 2007-09-25 | 2022-11-21 | Otsuka Pharma Co Ltd | Kropsintern anordning med virtuel dipol signalforstærkning |
US20090087483A1 (en) * | 2007-09-27 | 2009-04-02 | Sison Raymundo A | Oral dosage combination pharmaceutical packaging |
US20090088618A1 (en) | 2007-10-01 | 2009-04-02 | Arneson Michael R | System and Method for Manufacturing a Swallowable Sensor Device |
CL2008003008A1 (es) | 2007-10-12 | 2009-10-02 | Bigtec Private Ltd | Un micro dispositivo portatil de reaccion en cadena de polimerasa (pcr) basado en un micro chip de ceramica de coccion conjunta de baja temperatura (ltcc) que comprende camara de reaccion, calentador, control de temperatura del calentador, deteccion optica de interfaz de comunicacion, y el metodo para monitorearlo y controlarlo. |
WO2009051965A1 (en) | 2007-10-14 | 2009-04-23 | Board Of Regents, The University Of Texas System | A wireless neural recording and stimulating system for pain management |
US20090105561A1 (en) | 2007-10-17 | 2009-04-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
US8134459B2 (en) | 2007-10-19 | 2012-03-13 | Smiths Medical Asd, Inc. | Wireless telecommunications system adaptable for patient monitoring |
US20090105567A1 (en) | 2007-10-19 | 2009-04-23 | Smiths Medical Pm, Inc. | Wireless telecommunications network adaptable for patient monitoring |
US8139225B2 (en) | 2007-10-24 | 2012-03-20 | Siemens Medical Solutions Usa, Inc. | System for processing patient monitoring power and data signals |
GB0721117D0 (en) | 2007-10-26 | 2007-12-05 | T & Medical Ltd | system for assisting in drug dose optimisaion |
US20090112626A1 (en) | 2007-10-30 | 2009-04-30 | Cary Talbot | Remote wireless monitoring, processing, and communication of patient data |
WO2009063377A1 (en) | 2007-11-13 | 2009-05-22 | Koninklijke Philips Electronics N.V. | Ingestible electronic capsule |
ES2661739T3 (es) * | 2007-11-27 | 2018-04-03 | Proteus Digital Health, Inc. | Sistemas de comunicación transcorporal que emplean canales de comunicación |
US20090143696A1 (en) | 2007-11-29 | 2009-06-04 | Integrated Sensing Systems, Inc. | Sensor unit and procedure for monitoring intracranial physiological properties |
US20090149839A1 (en) | 2007-12-11 | 2009-06-11 | Hyde Roderick A | Treatment techniques using ingestible device |
US20090287109A1 (en) | 2008-05-14 | 2009-11-19 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Circulatory monitoring systems and methods |
US20100036269A1 (en) | 2008-08-07 | 2010-02-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Circulatory monitoring systems and methods |
US20090157113A1 (en) | 2007-12-18 | 2009-06-18 | Ethicon Endo-Surgery, Inc. | Wearable elements for implantable restriction systems |
JP5149610B2 (ja) | 2007-12-19 | 2013-02-20 | 株式会社日立ハイテクノロジーズ | プラズマ処理装置 |
US9011327B2 (en) | 2007-12-20 | 2015-04-21 | Koninklijke Philips N.V. | Capacitive sensing and communicating |
JP5091657B2 (ja) | 2007-12-21 | 2012-12-05 | 株式会社東芝 | 無線通信装置及び無線通信方法 |
US8177611B2 (en) | 2007-12-21 | 2012-05-15 | Sony Computer Entertainment America Llc | Scheme for inserting a mimicked performance into a scene and providing an evaluation of same |
US9259591B2 (en) | 2007-12-28 | 2016-02-16 | Cyberonics, Inc. | Housing for an implantable medical device |
US20090171180A1 (en) | 2007-12-28 | 2009-07-02 | Trevor Pering | Method and apparatus for configuring wearable sensors |
WO2009091910A1 (en) | 2008-01-15 | 2009-07-23 | Cardiac Pacemakers, Inc. | Implantable medical device with wireless communications |
EP2230993B1 (en) | 2008-01-15 | 2018-08-15 | Cardiac Pacemakers, Inc. | Implantable medical device with antenna |
US20090182207A1 (en) * | 2008-01-16 | 2009-07-16 | Tenxsys Inc. | Ingestible animal health sensor |
GB2456567B (en) | 2008-01-18 | 2010-05-05 | Oxford Biosignals Ltd | Novelty detection |
JP5132335B2 (ja) | 2008-01-29 | 2013-01-30 | 富士フイルム株式会社 | カプセル内視鏡及びカプセル内視鏡システム |
JP5233298B2 (ja) | 2008-02-01 | 2013-07-10 | 宇部興産株式会社 | ポリイミドフィルムおよびポリイミドフィルムの製造方法 |
US20090194747A1 (en) | 2008-02-04 | 2009-08-06 | Vale Inco Limited | Method for improving environmental stability of cathode materials for lithium batteries |
JP5156427B2 (ja) * | 2008-02-13 | 2013-03-06 | 富士フイルム株式会社 | カプセル内視鏡システム |
MY161533A (en) * | 2008-03-05 | 2017-04-28 | Proteus Digital Health Inc | Multi-mode communication ingestible event markers and systems, and methods of using the same |
JP5324604B2 (ja) | 2008-03-06 | 2013-10-23 | ストライカー・コーポレイション | 折り畳むことができる移植可能な電極アレイアセンブリおよび該アセンブリを移植するためのツール |
WO2009112977A1 (en) | 2008-03-10 | 2009-09-17 | Koninklijke Philips Electronics N.V. | Ecg monitoring system with configurable alarm limits |
JP5543380B2 (ja) | 2008-03-10 | 2014-07-09 | コーニンクレッカ フィリップス エヌ ヴェ | 連続的な外来患者のecg監視システム |
US7983189B2 (en) | 2008-03-12 | 2011-07-19 | Embarq Holdings Company, Llc | System and method for tracking performance and service level agreement compliance for multipoint packet services |
US20090243833A1 (en) | 2008-03-31 | 2009-10-01 | Ching Ching Huang | Monitoring system and method for patient care |
US20110163871A1 (en) | 2008-04-01 | 2011-07-07 | Shmuel Einav | Rfid monitoring of drug regimen compliance |
EP2106737B1 (en) * | 2008-04-03 | 2012-01-25 | Olympus Medical Systems Corp. | Antenna unit and receiving apparatus for capsule medical apparatus |
EP2265169A4 (en) | 2008-04-03 | 2013-01-09 | Kai Medical Inc | NON-CONTACT PHYSIOLOGICAL MOTION SENSORS AND METHODS OF USE |
ES2605615T3 (es) | 2008-04-18 | 2017-03-15 | Korsch Ag | Dispositivo para insertar incrustaciones en las matrices de una prensa rotativa para tabletas |
WO2009131664A2 (en) | 2008-04-21 | 2009-10-29 | Carl Frederick Edman | Metabolic energy monitoring system |
US8185646B2 (en) | 2008-11-03 | 2012-05-22 | Veritrix, Inc. | User authentication for social networks |
US8170515B2 (en) * | 2008-05-21 | 2012-05-01 | Medtronic, Inc. | Method and apparatus for the phased detection of a signal including a frequency deviation detection phase |
US20090292194A1 (en) | 2008-05-23 | 2009-11-26 | Corventis, Inc. | Chiropractic Care Management Systems and Methods |
US8989837B2 (en) | 2009-12-01 | 2015-03-24 | Kyma Medical Technologies Ltd. | Methods and systems for determining fluid content of tissue |
US9538937B2 (en) | 2008-06-18 | 2017-01-10 | Covidien Lp | System and method of evaluating a subject with an ingestible capsule |
US20090318303A1 (en) * | 2008-06-20 | 2009-12-24 | International Business Machines Corporation | Microfluidic selection of library elements |
US9014778B2 (en) | 2008-06-24 | 2015-04-21 | Biosense Webster, Inc. | Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems |
CH699071A2 (fr) | 2008-07-02 | 2010-01-15 | Flakes S A | Dispositif de freinage et/ou de blocage mécanique. |
WO2010005953A2 (en) | 2008-07-07 | 2010-01-14 | Cardullo Mario W | Dynamically distributable nano rfid device and related method |
SG195535A1 (en) | 2008-07-08 | 2013-12-30 | Proteus Digital Health Inc | Ingestible event marker data framework |
US8152020B2 (en) | 2008-07-09 | 2012-04-10 | Flowers Mary E | Dosage dispensing and tracking container |
EP2320875B1 (en) | 2008-07-23 | 2019-07-03 | I-Property Holding Corp. | Secure tracking of tablets |
KR101214453B1 (ko) * | 2008-08-13 | 2012-12-24 | 프로테우스 디지털 헬스, 인코포레이티드 | 복용 가능한 회로 |
KR101028584B1 (ko) | 2008-08-27 | 2011-04-12 | 주식회사 바이오프로테크 | 일회용 유도전극 및 이에 접속되는 리드선 |
US20100056878A1 (en) | 2008-08-28 | 2010-03-04 | Partin Dale L | Indirectly coupled personal monitor for obtaining at least one physiological parameter of a subject |
GB2463054A (en) | 2008-08-30 | 2010-03-03 | Adavanced Telecare Solutions L | Device for monitoring the removal of items placed in compartments of a blister package using ambient light |
US9943644B2 (en) | 2008-08-31 | 2018-04-17 | Abbott Diabetes Care Inc. | Closed loop control with reference measurement and methods thereof |
US20100063841A1 (en) | 2008-09-05 | 2010-03-11 | Vital Data Technology, Llc | System and method of notifying designated entities of access to personal medical records |
US8224596B2 (en) | 2008-09-09 | 2012-07-17 | International Business Machines Corporation | Portable device battery optimization routing system |
US20100069002A1 (en) | 2008-09-16 | 2010-03-18 | Vcan Sports, Inc. | Method and apparatus for a wireless communication device utilizing bluetooth technology |
WO2010057049A2 (en) | 2008-11-13 | 2010-05-20 | Proteus Biomedical, Inc. | Ingestible therapy activator system and method |
CN102271578B (zh) | 2008-12-11 | 2013-12-04 | 普罗秋斯数字健康公司 | 使用便携式电子内脏造影系统的胃肠功能的评估及其使用方法 |
TWI424832B (zh) | 2008-12-15 | 2014-02-01 | Proteus Digital Health Inc | 與身體有關的接收器及其方法 |
US20100160742A1 (en) | 2008-12-18 | 2010-06-24 | General Electric Company | Telemetry system and method |
AU2010203625A1 (en) | 2009-01-06 | 2011-07-21 | Proteus Digital Health, Inc. | Ingestion-related biofeedback and personalized medical therapy method and system |
CA2750151A1 (en) | 2009-01-06 | 2010-07-15 | Proteus Biomedical, Inc. | High-throughput production of ingestible event markers |
TWI602561B (zh) | 2009-01-06 | 2017-10-21 | 波提亞斯數位康健公司 | 醫藥劑量傳送系統 |
EP2208458A1 (de) | 2009-01-14 | 2010-07-21 | Roche Diagnostics GmbH | Medizinisches Überwachungsnetzwerk |
FR2941817B1 (fr) | 2009-01-30 | 2011-04-01 | Centre Nat Rech Scient | Procede pour la preparation d'une composition d'electrode |
JP4576462B2 (ja) | 2009-01-30 | 2010-11-10 | 株式会社バッファロー | ルータ装置 |
US8224667B1 (en) | 2009-02-06 | 2012-07-17 | Sprint Communications Company L.P. | Therapy adherence methods and architecture |
US8395521B2 (en) | 2009-02-06 | 2013-03-12 | University Of Dayton | Smart aerospace structures |
US8073401B2 (en) | 2009-02-17 | 2011-12-06 | Rfaxis, Inc. | Multi mode radio frequency transceiver front end circuit with inter-stage matching circuit |
WO2010099268A1 (en) | 2009-02-25 | 2010-09-02 | Xanthia Global Limited | Wireless physiology monitor |
US8452366B2 (en) | 2009-03-16 | 2013-05-28 | Covidien Lp | Medical monitoring device with flexible circuitry |
US8004900B2 (en) | 2009-03-17 | 2011-08-23 | Sandisk Technologies Inc. | Controlling select gate voltage during erase to improve endurance in non-volatile memory |
WO2010111403A2 (en) | 2009-03-25 | 2010-09-30 | Proteus Biomedical, Inc. | Probablistic pharmacokinetic and pharmacodynamic modeling |
WO2010111489A2 (en) | 2009-03-27 | 2010-09-30 | LifeWatch Corp. | Methods and apparatus for processing physiological data acquired from an ambulatory physiological monitoring unit |
US8805528B2 (en) | 2009-03-31 | 2014-08-12 | Medtronic, Inc. | Channel assessment and selection for wireless communication between medical devices |
US8253586B1 (en) | 2009-04-24 | 2012-08-28 | Mayfonk Art, Inc. | Athletic-wear having integral measuring sensors |
CN102458236B (zh) | 2009-04-28 | 2016-01-27 | 普罗秋斯数字健康公司 | 高可靠性的可摄入事件标记器及其使用方法 |
WO2010132331A2 (en) | 2009-05-12 | 2010-11-18 | Proteus Biomedical, Inc. | Ingestible event markers comprising an ingestible component |
US20100299155A1 (en) | 2009-05-19 | 2010-11-25 | Myca Health, Inc. | System and method for providing a multi-dimensional contextual platform for managing a medical practice |
US8738118B2 (en) | 2009-05-20 | 2014-05-27 | Sotera Wireless, Inc. | Cable system for generating signals for detecting motion and measuring vital signs |
US8698006B2 (en) | 2009-06-04 | 2014-04-15 | Morgan Advanced Ceramics, Inc. | Co-fired metal and ceramic composite feedthrough assemblies for use at least in implantable medical devices and methods for making the same |
US8468115B2 (en) | 2009-06-25 | 2013-06-18 | George Mason Intellectual Properties, Inc. | Cyclical behavior modification |
RU2417884C2 (ru) | 2009-08-03 | 2011-05-10 | Фирдаус Усманович Замалеев | Устройство для нанесения термопластичных покрытий на внутреннюю поверхность металлических труб |
BR112012003294B1 (pt) | 2009-08-14 | 2021-06-22 | Telefonaktiebolaget Lm Ericsson (Publ) | Método para estabelecer uma conexão entre um terminal de origem e um terminal de destino, nó de rede para uma rede de núcleo, ponto de conexão de acesso de uma rede de núcleo, portadora de dados eletronicamente legíveis, e, meio de armazenamento legível por computador |
WO2011022525A1 (en) | 2009-08-21 | 2011-02-24 | 3M Innovative Properties Company | Methods and products for illuminating tissue |
US8558563B2 (en) | 2009-08-21 | 2013-10-15 | Proteus Digital Health, Inc. | Apparatus and method for measuring biochemical parameters |
US9024766B2 (en) | 2009-08-28 | 2015-05-05 | The Invention Science Fund, Llc | Beverage containers with detection capability |
US20110230732A1 (en) | 2009-09-14 | 2011-09-22 | Philometron, Inc. | System utilizing physiological monitoring and electronic media for health improvement |
US8207731B2 (en) | 2009-09-30 | 2012-06-26 | Thermofisher Scientific | Apparatus and method for automatic product effect compensation in radio frequency metal detectors |
US20110077718A1 (en) | 2009-09-30 | 2011-03-31 | Broadcom Corporation | Electromagnetic power booster for bio-medical units |
US8838217B2 (en) | 2009-11-10 | 2014-09-16 | Makor Issues And Rights Ltd. | System and apparatus for providing diagnosis and personalized abnormalities alerts and for providing adaptive responses in clinical trials |
US20110270135A1 (en) | 2009-11-30 | 2011-11-03 | Christopher John Dooley | Augmented reality for testing and training of human performance |
UA109424C2 (uk) | 2009-12-02 | 2015-08-25 | Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки | |
US8917798B2 (en) | 2009-12-03 | 2014-12-23 | Qualcomm Incorporated | Method and apparatus for distributed processing for wireless sensors |
US9451897B2 (en) | 2009-12-14 | 2016-09-27 | Medtronic Monitoring, Inc. | Body adherent patch with electronics for physiologic monitoring |
EP2515747A2 (en) | 2009-12-23 | 2012-10-31 | DELTA, Dansk Elektronik, Lys & Akustik | A monitoring system |
US8560040B2 (en) | 2010-01-04 | 2013-10-15 | Koninklijke Philips N.V. | Shielded biomedical electrode patch |
NL2004210C2 (en) | 2010-02-08 | 2011-08-09 | Ipn Ip Bv | A refillable liquid product container system. |
KR101034998B1 (ko) | 2010-02-18 | 2011-05-17 | 대한메디칼시스템(주) | 스냅전극과 와이어의 체결구조 |
US9075910B2 (en) | 2010-03-11 | 2015-07-07 | Philometron, Inc. | Physiological monitor system for determining medication delivery and outcome |
WO2011127252A2 (en) | 2010-04-07 | 2011-10-13 | Proteus Biomedical, Inc. | Miniature ingestible device |
EP2557986A4 (en) | 2010-04-11 | 2014-01-22 | Proteus Digital Health Inc | APPARATUS, SYSTEM AND METHOD FOR DETECTION AND ADMINISTRATION OF MEDICINAL DOSE |
WO2011133799A1 (en) | 2010-04-21 | 2011-10-27 | Northwestern University | Medical evaluation system and method using sensors in mobile devices |
DK2568878T3 (en) | 2010-05-12 | 2018-10-29 | Irhythm Tech Inc | Interior features and design elements for long-term adhesion |
CA2807340C (en) | 2010-05-21 | 2019-02-12 | Medicomp, Inc. | Retractable multi-use cardiac monitor |
US8301232B2 (en) | 2010-06-08 | 2012-10-30 | Alivecor, Inc. | Wireless, ultrasonic personal health monitoring system |
US20110301439A1 (en) | 2010-06-08 | 2011-12-08 | AliveUSA LLC | Wireless, ultrasonic personal health monitoring system |
WO2011159337A1 (en) | 2010-06-14 | 2011-12-22 | Trutag Technologies, Inc. | Labeling and verifying an item with an identifier |
KR101760663B1 (ko) | 2010-06-14 | 2017-08-04 | 트루테그 테크놀로지스, 인코포레이티드 | 패키지에서 아이템을 검증하기 위한 시스템 |
EP2580687A4 (en) | 2010-06-14 | 2014-04-30 | Trutag Technologies Inc | SYSTEM FOR CHECKING AN ELEMENT IN A PACKAGE WITH A DATABASE |
KR20130057451A (ko) | 2010-06-14 | 2013-05-31 | 트루테그 테크놀로지스, 인코포레이티드 | 식별자를 가진 패키징된 아이템을 생성하기 위한 시스템 |
US20130196012A1 (en) | 2010-11-30 | 2013-08-01 | Wellesley Pharmaceuticals, Llc | Extended-release formulation for reducing the frequency of urination and method of use thereof |
US20120016231A1 (en) | 2010-07-18 | 2012-01-19 | Medical Scan Technologies, Inc. | System and method for three dimensional cosmetology imaging with structured light |
EP3023361B1 (de) | 2010-07-22 | 2018-12-26 | K-fee System GmbH | Portionskapsel mit kennung |
US9585620B2 (en) | 2010-07-27 | 2017-03-07 | Carefusion 303, Inc. | Vital-signs patch having a flexible attachment to electrodes |
WO2012015756A2 (en) | 2010-07-29 | 2012-02-02 | Proteus Biomedical, Inc. | Hybrid housing for implantable medical device |
US20120032816A1 (en) | 2010-08-06 | 2012-02-09 | Cho Jeffrey C | System And Method For Controlling Sport Event Transducers |
DE102010039416A1 (de) | 2010-08-17 | 2012-02-23 | Varta Micro Innovation Gmbh | Flexible Batterieelektroden und ihre Herstellung |
US8697057B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
WO2012035200A2 (en) | 2010-09-13 | 2012-03-22 | Nokia Corporation | Haptic communication |
WO2012040390A2 (en) | 2010-09-21 | 2012-03-29 | Somaxis Incorporated | Methods for assessing and optimizing muscular performance |
US9167991B2 (en) * | 2010-09-30 | 2015-10-27 | Fitbit, Inc. | Portable monitoring devices and methods of operating same |
JP2014504902A (ja) | 2010-11-22 | 2014-02-27 | プロテウス デジタル ヘルス, インコーポレイテッド | 医薬品を有する摂取可能なデバイス |
UA109691C2 (uk) * | 2010-12-29 | 2015-09-25 | Бездротові джерела енергії для використання в інтегральних схемах | |
WO2012097505A1 (zh) | 2011-01-18 | 2012-07-26 | 北京超思电子技术有限责任公司 | 测量设备 |
US8647358B2 (en) | 2011-01-21 | 2014-02-11 | Obalon Therapeutics Inc. | Intragastric device |
US20120197144A1 (en) | 2011-01-27 | 2012-08-02 | Koninklijke Philips Electronics N.V. | Exchangeable electrode and ecg cable snap connector |
GB2487758A (en) | 2011-02-03 | 2012-08-08 | Isansys Lifecare Ltd | Health monitoring electrode assembly |
WO2012112561A1 (en) | 2011-02-18 | 2012-08-23 | Proteus Biomedical, Inc. | Wearable personal communicator apparatus, system, and method |
GB2535917B (en) | 2011-02-25 | 2017-02-01 | Tna Australia Pty Ltd | A chute assembly for a packaging apparatus including two chutes and a metal detector |
US9439599B2 (en) | 2011-03-11 | 2016-09-13 | Proteus Digital Health, Inc. | Wearable personal body associated device with various physical configurations |
WO2012129256A1 (en) | 2011-03-21 | 2012-09-27 | Purafil, Inc. | Systems and methods for detecting and identifying contaminants in a gaseous environment |
US9626650B2 (en) | 2011-04-14 | 2017-04-18 | Elwha Llc | Cost-effective resource apportionment technologies suitable for facilitating therapies |
JP6018623B2 (ja) | 2011-04-14 | 2016-11-02 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 患者モニタのための段階式アラーム方法 |
US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
US9158890B2 (en) | 2011-07-27 | 2015-10-13 | At&T Mobility Ii Llc | Mobile applications and methods for conveying performance information of a cardiac pacemaker |
US8785569B2 (en) | 2011-11-22 | 2014-07-22 | Original Biomedicals Co., Ltd. | Drug carrier with chelating complex micelles and the application thereof |
US20130129869A1 (en) | 2011-11-23 | 2013-05-23 | Hooman Hafezi | Compositions comprising a shelf-life stability component |
US9968284B2 (en) | 2011-12-02 | 2018-05-15 | Clinitech, Llc | Anti-interferent barrier layers for non-invasive transdermal sampling and analysis device |
FR2985382B1 (fr) | 2012-01-03 | 2015-03-13 | Air Liquide | Pile a combustible |
US20130171596A1 (en) | 2012-01-04 | 2013-07-04 | Barry J. French | Augmented reality neurological evaluation method |
EP2817863A1 (en) | 2012-01-08 | 2014-12-31 | Powermat Technologies Ltd. | System and method for providing and controlling inductive power charging |
US20130185228A1 (en) | 2012-01-18 | 2013-07-18 | Steven Dresner | System and Method of Data Collection, Analysis and Distribution |
WO2013138169A2 (en) | 2012-03-14 | 2013-09-19 | E. I. Du Pont De Nemours And Company | Mcm-48 templated carbon compositions, electrodes, cells, methods for making and methods for using |
US20130275296A1 (en) | 2012-03-16 | 2013-10-17 | esdatanetworks INC | Proximal Customer Transaction Incented By Donation of Auto-Boarded Merchant |
US8908943B2 (en) | 2012-05-22 | 2014-12-09 | Orca Health, Inc. | Personalized anatomical diagnostics and simulations |
US9277864B2 (en) | 2012-05-24 | 2016-03-08 | Vital Connect, Inc. | Modular wearable sensor device |
WO2014018454A1 (en) | 2012-07-23 | 2014-01-30 | Proteus Digital Health, Inc. | Techniques for manufacturing ingestible event markers comprising an ingestible component |
WO2014047205A1 (en) | 2012-09-21 | 2014-03-27 | Proteus Digital Health, Inc. | Wireless wearable apparatus, system, and method |
JP5869736B2 (ja) | 2012-10-18 | 2016-02-24 | プロテウス デジタル ヘルス, インコーポレイテッド | 通信デバイス用の電源において電力消失およびブロードキャスト電力を適応的に最適化するための装置、システム、および方法 |
TWI659994B (zh) | 2013-01-29 | 2019-05-21 | 美商普羅托斯數位健康公司 | 高度可膨脹之聚合型薄膜及包含彼之組成物 |
EP2973778B1 (en) | 2013-03-13 | 2018-08-22 | Brigham and Women's Hospital, Inc. | Safely ingestible batteries |
US20140280125A1 (en) | 2013-03-14 | 2014-09-18 | Ebay Inc. | Method and system to build a time-sensitive profile |
JP5941240B2 (ja) | 2013-03-15 | 2016-06-29 | プロテウス デジタル ヘルス, インコーポレイテッド | 金属検出器装置、システム、および方法 |
US20140308930A1 (en) | 2013-04-12 | 2014-10-16 | Bao Tran | Timely, glanceable information on a wearable device |
US9529385B2 (en) | 2013-05-23 | 2016-12-27 | Medibotics Llc | Smart watch and human-to-computer interface for monitoring food consumption |
US10545132B2 (en) | 2013-06-25 | 2020-01-28 | Lifescan Ip Holdings, Llc | Physiological monitoring system communicating with at least a social network |
US9086490B2 (en) | 2013-08-27 | 2015-07-21 | Franklin H. Cocks | Red boron solid state detector |
JP2015045773A (ja) | 2013-08-29 | 2015-03-12 | 富士フイルム株式会社 | 走査光学系、光走査装置および放射線画像読取装置 |
JP5936584B2 (ja) | 2013-08-29 | 2016-06-22 | 富士フイルム株式会社 | 放射線画像検出装置及び製造方法 |
US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
US9517012B2 (en) | 2013-09-13 | 2016-12-13 | Welch Allyn, Inc. | Continuous patient monitoring |
US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
US20150127738A1 (en) | 2013-11-05 | 2015-05-07 | Proteus Digital Health, Inc. | Bio-language based communication system |
US20150149375A1 (en) | 2013-11-22 | 2015-05-28 | Proteus Digital Health, Inc. | Crowd endorsement system |
WO2015112604A1 (en) | 2014-01-22 | 2015-07-30 | Proteus Digital Health, Inc. | Edible adhesives and ingestible compositions including the same |
WO2015119911A1 (en) | 2014-02-04 | 2015-08-13 | Proteus Digital Health, Inc. | Enhanced ingestible event indicators and methods for making and using the same |
NO341191B1 (no) | 2014-04-02 | 2017-09-04 | Am Nutrition As | Næringsprodukt med animalsk ensilasje og framgangsmåte for å framstille næringsproduktet. |
US9226663B2 (en) | 2014-04-07 | 2016-01-05 | Physical Enterprises, Inc. | Systems and methods for optical isolation in measuring physiological parameters |
US9537010B2 (en) | 2015-02-04 | 2017-01-03 | Taiwan Semiconductor Manufacturing Co., Ltd. | Semiconductor device structure and method for forming the same |
US20160380708A1 (en) | 2015-06-26 | 2016-12-29 | Proteus Digital Health, Inc. | Systems and methods for resolving ingestible event marker (iem) contention |
US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
KR20210018961A (ko) | 2016-07-22 | 2021-02-18 | 프로테우스 디지털 헬스, 인코포레이티드 | 섭취 가능한 이벤트 마커의 전자기 감지 및 검출 |
IL265827B2 (en) | 2016-10-26 | 2023-03-01 | Proteus Digital Health Inc | Methods for producing capsules with ingestible event markers |
-
2006
- 2006-04-28 EP EP11006868.1A patent/EP2392258B1/en active Active
- 2006-04-28 EP EP13182679.4A patent/EP2671507A3/en not_active Ceased
- 2006-04-28 CA CA2789262A patent/CA2789262C/en active Active
- 2006-04-28 DK DK06751858.9T patent/DK1889198T3/da active
- 2006-04-28 SI SI200631882T patent/SI1889198T1/sl unknown
- 2006-04-28 EP EP06751858.9A patent/EP1889198B1/en active Active
- 2006-04-28 PL PL06751858T patent/PL1889198T3/pl unknown
- 2006-04-28 EP EP20215913.3A patent/EP3827747A1/en active Pending
- 2006-04-28 ES ES06751858.9T patent/ES2528403T3/es active Active
- 2006-04-28 EP EP13182685.1A patent/EP2671508B1/en active Active
- 2006-04-28 WO PCT/US2006/016370 patent/WO2006116718A2/en active Application Filing
- 2006-04-28 AU AU2006239221A patent/AU2006239221C1/en active Active
- 2006-04-28 US US11/912,475 patent/US8847766B2/en active Active
- 2006-04-28 CA CA2608144A patent/CA2608144C/en active Active
- 2006-04-28 PT PT06751858T patent/PT1889198E/pt unknown
- 2006-04-28 CN CN2006800238386A patent/CN101287411B/zh active Active
- 2006-04-28 CN CN201110212586.4A patent/CN102379684B/zh active Active
- 2006-04-28 CA CA2789097A patent/CA2789097C/en active Active
- 2006-04-28 CN CN2013100090910A patent/CN103259027A/zh active Pending
- 2006-04-28 JP JP2008509195A patent/JP2008539047A/ja not_active Withdrawn
-
2007
- 2007-10-24 IL IL186898A patent/IL186898A/en active IP Right Grant
-
2008
- 2008-08-15 HK HK08109088.6A patent/HK1113652A1/zh unknown
-
2009
- 2009-03-13 US US12/404,184 patent/US8674825B2/en active Active
- 2009-09-21 US US12/564,017 patent/US7978064B2/en active Active
-
2010
- 2010-11-18 US US12/949,720 patent/US9119554B2/en active Active
-
2011
- 2011-06-03 US US13/153,312 patent/US8816847B2/en active Active
- 2011-07-19 IL IL214183A patent/IL214183A/en active IP Right Grant
- 2011-07-25 JP JP2011162568A patent/JP5088978B2/ja active Active
- 2011-10-20 JP JP2011231159A patent/JP5400121B2/ja active Active
- 2011-11-22 IL IL216535A patent/IL216535A/en active IP Right Grant
-
2012
- 2012-06-29 JP JP2012147371A patent/JP5730822B2/ja active Active
- 2012-07-26 HK HK12107364.9A patent/HK1166680A1/zh unknown
-
2013
- 2013-05-24 JP JP2013109680A patent/JP2013176625A/ja not_active Withdrawn
- 2013-05-24 JP JP2013109679A patent/JP5683641B2/ja active Active
-
2014
- 2014-07-25 US US14/341,639 patent/US20150080680A1/en not_active Abandoned
-
2015
- 2015-01-13 US US14/596,056 patent/US9681842B2/en active Active
- 2015-01-13 US US14/596,049 patent/US20150150480A1/en not_active Abandoned
- 2015-04-29 US US14/699,681 patent/US20150230729A1/en not_active Abandoned
- 2015-09-25 US US14/865,508 patent/US9649066B2/en active Active
-
2017
- 2017-03-30 US US15/474,811 patent/US10542909B2/en active Active
- 2017-06-15 IL IL252946A patent/IL252946B/en active IP Right Grant
- 2017-10-20 US US15/788,968 patent/US10610128B2/en active Active
-
2018
- 2018-11-04 IL IL262761A patent/IL262761B/en active IP Right Grant
-
2019
- 2019-06-23 IL IL267584A patent/IL267584A/en active IP Right Grant
- 2019-12-18 US US16/719,111 patent/US11044024B2/en active Active
-
2020
- 2020-10-05 US US17/062,897 patent/US11476952B2/en active Active
- 2020-11-25 IL IL278979A patent/IL278979B/en unknown
-
2021
- 2021-05-20 US US17/325,812 patent/US20220116124A1/en not_active Abandoned
-
2022
- 2022-07-28 US US17/876,182 patent/US20230163864A1/en not_active Abandoned
- 2022-08-24 US US17/894,907 patent/US20230216595A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5318557A (en) * | 1992-07-13 | 1994-06-07 | Elan Medical Technologies Limited | Medication administering device |
US5925030A (en) * | 1994-08-15 | 1999-07-20 | Elan Corporation, Plc | Orally administrable delivery device |
US5792048A (en) * | 1996-09-03 | 1998-08-11 | Schaefer; Guenter | Indentification pill with integrated microchip: smartpill, smartpill with integrated microchip and microprocessor for medical analyses and a smartpill, smartbox, smartplague, smartbadge or smartplate for luggage control on commercial airliners |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102379684B (zh) | 药物信息系统 | |
CA3041518C (en) | Pharma-informatics system | |
AU2011250717B2 (en) | Pharma-informatics system | |
AU2015201291A1 (en) | Pharma-informatics system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1166680 Country of ref document: HK |
|
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: M. Zdeblick Inventor after: T. Robertson Inventor after: Pikelny Aleksandr Inventor after: H. Hafeich Inventor before: M. Zdeblick Inventor before: A. Thompson Inventor before: Pikelny Aleksandr Inventor before: T. Robertson |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZDEBLICK MARK THOMPSON ANDREW PIKELNY ALEKSANDR ROBERTSON TIMOTHY TO: ZDEBLICK MARK T LUO BOSEN PIKELNY ALEKSANDR HAFEZI HOOMAN |
|
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: California, USA Applicant after: Proteus Digital Health, Inc. Address before: California, USA Applicant before: PROTEUS BIOMEDICAL, Inc. |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: PROTEUS BIOMEDICAL INC. TO: PROTOUS BIOMEDICAL INC. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1166680 Country of ref document: HK |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210218 Address after: Japan Tokyo Chiyoda Kanda Cho Division 2 chome 9 GA Patentee after: OTSUKA PHARMACEUTICAL Co.,Ltd. Address before: American Maryland Patentee before: OTSUKA AMERICA PHARMACEUTICAL, Inc. Effective date of registration: 20210218 Address after: American Maryland Patentee after: OTSUKA AMERICA PHARMACEUTICAL, Inc. Address before: California, USA Patentee before: Proteus Digital Health, Inc. |