CN102485167A - Ultramicro implantation type blood pressure measuring and monitoring method and device - Google Patents
Ultramicro implantation type blood pressure measuring and monitoring method and device Download PDFInfo
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- CN102485167A CN102485167A CN2010105797106A CN201010579710A CN102485167A CN 102485167 A CN102485167 A CN 102485167A CN 2010105797106 A CN2010105797106 A CN 2010105797106A CN 201010579710 A CN201010579710 A CN 201010579710A CN 102485167 A CN102485167 A CN 102485167A
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Abstract
The invention relates to an ultralow-power-consumption ultra-small-volume in-vivo implantation type blood pressure signal measuring and monitoring method and device. The device is in the form of a capsule. An electromagnetic coupling energy supply system and a rechargeable technology are utilized; a special blood pressure sensing system is utilized to complete blood pressure signal transfer, ultralow-power-consumption signal acquisition and wireless reception and transmission; an in-vitro signal data receiving system completes wireless receiving and conditioning of the signal; and a signal data processing and analyzing system is used for data storage and analysis via an interface module. The invention can monitor the contractive pressure and diastolic pressure in a long-term, safe, stable and direct way in a natural physiological state to acquire mean pressure, pulse rate, blood volume, blood flow and other related parameters, thereby completing display, storage and printing output of blood pressure waveform. The invention is widely used in pharmacological and pathological tests, is effectively used in researching cardiovascular disease, hypertension and diabetes, judging curative effects of related therapeutic drugs, monitoring blood pressure during and after surgeries for diagnosing and treating various diseases, and is applicable to other research fields.
Description
Affiliated technical field
The present technique invention relates to the method and apparatus that super low-power consumption ultra-small volume vivo implantation type blood pressure signal is measured monitoring; Especially can be under the physiological status of nature long-term, safe, stable direct measurement blood pressure, real-time monitor systolic pressure, diastolic pressure; Obtain relevant parameters such as mean pressure, pulse frequency, blood volume and blood flow, and accomplish demonstration, storage, the printout of blood pressure waveform; Belong to biomedical engineering field.
Background technology
At present, the Ke Shi sound method of known blood pressure measurement employing causes blood pressure measurement can not truly fully objectively reflect the blood pressure index in method property error (comprising audition error, error in judgement, vision hysteresis error, decompression error on opportunity), operate miss (comprising venting decompression rate error, colligation degree of tightness error, detector position error, testee's site error), adapted instrumental error many errors such as (piezometer and stethoscope errors); The oscillographic method electric sphygmomanometer is measured unreliable, inaccurate, the data discrete of blood pressure; The indirect method of P-V method, pressure sensing, photoelectric sensing can not truly objectively be measured and the monitoring blood pressure signal.Adopt acquisition blood pressure relevant parameter that the direct measurement of vivo implantation type blood pressure can be authentic and valid and can long term monitoring; Embedded system is made up in domestic research institution and function has been carried out big quantity research, but is not still having perfect system solution and scheme aspect volume, the power consumption; External existing correlation technique is backward, the not enough perfecting scientific of solution, in the practical application request that can't satisfy the implanted blood pressure measurement aspect volume and the power consumption.Pathology, pharmacology and physiology scientific research field have urgent demand to implantation type wireless remote measurement and monitoring blood pressure and relevant parameter thereof, particularly in the judgement and the research of disease researches such as hypertensive diabetes, associated treatment curative effect of medication; Also need true and reliable blood pressure parameter the some diseases operation process to be monitored concern and attention that post-operative recovery is also special to parameters such as blood pressures to blood pressure in the diagnosis of all kinds of diseases and the treatment in a hurry.The develop rapidly of micro sensing technology in addition, the developing rapidly of semiconductor components and devices, chip functions is powerful and perfect, and also technological and method is given security for the advanced implantation type wireless monitoring of blood pressure of invention.
Summary of the invention
The present technique invention relates to the method and apparatus that super low-power consumption ultra-small volume vivo implantation type blood pressure signal is measured monitoring; Especially under can physiological status at nature for a long time, safely, stablize direct wireless telemetering and monitoring blood pressure, real-time monitor systolic pressure, diastolic pressure, obtain mean pressure, blood relevant parameters such as pulse frequency, blood volume and blood flow.Present technique invention provides a kind of signal transmission system based on micro pressure sensor-based system and ultra-micro power consumption ultra-small volume, in real time blood pressure signal and monitor the interior blood pressure relevant parameter of body in synchronous safety, reliable, the stable direct measuring body of implanted.Present technique invention comprises that ultra-micro power consumption ultra-small volume body in the body implants the miniature electronic capsule of blood pressure sensor-based system and signals collecting, external signal receiving record and monitoring system, external Computer signal Data Management Analysis system; The capsular blood pressure sensor-based system of present technique invention utilization miniature electronic is accomplished the conduction to blood pressure signal, the collection of the signal of super low-power consumption, special-purpose low-consumption wireless communication system; External signal data receiving record instrument system carries out the reception adjustment of data signal and handles storage, and the process interface module is carried out special-purpose software data monitoring for Computer signal Data Management Analysis system and analyzed data image demonstration, data storage, printout.
The present technique invention solves the technical scheme that its technical problem adopted: blood pressure signal is conducted to the signal condition processing module by physiological signal sensing extraction module has the wireless transmitter module emission after nursing one's health processing, carry out after external receiving system receives giving external computer data analytical system behind the signal processing.The miniature electronic capsule appearance of super low-power consumption ultra-small volume vivo implantation type blood pressure sensing and signals collecting is the capsule body shape; Whole implant capsule is long to be 13.8mm; Diameter is 9.5mm, is made up of wireless energy reception and power management functional module, chargeable button cell, blood pressure signal sensing extraction module, signal condition and processing capacity module, wireless/receipts communication function module, antenna, capsule shell; The rechargeable type wireless energy transfer system is through the supply of external radio-frequency energy; The three-dimensional receiving system of band automatic orientation is accomplished wireless energy transfer and is accomplished the rechargeable battery charging in the body; This system bulk is little, simple in structure, dependable performance, efficiency of transmission high, can eliminate the influence that the shortcoming of fixed capacity button cell off-capacity and energy that the unicoil wireless energy supply possibly occur are supplied with breakthrough in vivo in the implant system; Blood pressure signal sensing extraction module comprises pressure transmission conduit, pressure-sensitive gel, micro pressure sensor, sensor package shell etc.; Micro pressure sensor adopts silicon pressure drag full-bridge type sensing; Bridge is through special handling than resistance; Resistance can be up to 50K, the power consumption of the pick off that greatly brings high blood pressure down, the long term monitoring of realization blood pressure signal; External signal programmable data receiving record system comprises antenna, receipts/send out assemblies such as communication function module, signal processing function module, signal store function module, data-interface; Receptor can receive the signal of a plurality of implants; Receptor can be discerned implant serial number and function automatically; Control implant contactor receives implant and sends signal, and effective range is at 0.5～10 meter; A plurality of implants in range of receiving can receive simultaneously, monitoring when realizing a plurality of body, and the output signal is amplified analog signal 0～5V, exportablely gives other recording system record analyses.External signal data Treatment Analysis system is made up of computer, data-interface, special-purpose software, outut device, PRN device.
The invention has the beneficial effects as follows: long-term under the physiological status of nature, safety, stable, directly monitor systolic pressure, diastolic pressure; Obtain mean pressure, pulse frequency, blood volume and blood flow relevant parameter; Monitoring physiological activity situation is analyzed each item blood pressure index of correlation in the body; The experimentation that is widely used in pharmacology, physiology, pathology; Effectively be applied to cardiovascular and Neuroscience Research; Help setting up all kinds of disease models; Be applied to the other field Potential as a researcher; The detection of blood pressure signal and regressive after sale monitoring of blood pressure in effectively being applied to perform the operation, this invention also can be monitored and record analysis a plurality of individualities in real time synchronously, the effectively record analysis of experimental data storage.
Description of drawings
Below in conjunction with accompanying drawing and embodiment the present invention is further specified
Fig. 1 is that ultra micro small size body is implanted into the blood pressure measurement capsule system:
The whole capsule of this miniature electronic capsule system is long to be 13.8mm, and diameter is 9.5mm; (1) silica gel sealing shell among the figure adopts silica gel material, and good biocompatibility, and non-leakage, does not infect not blood coagulation; (2) be three-dimensional and band automatic orientation wireless energy supply receiving coil; (3) power management module; (4) rechargeable battery; (5) magnetic control power supply control; (2) (3) (4) (5) are formed the power suppling part branch jointly; This module is accomplished radio function and is carried out power management and battery is charged; And the electrical control of adopting the magnetic switch mode to accomplish system guarantees absolute electrical isolation and open close; Realize power supply supply steady in a long-term; This system bulk is little, simple in structure, dependable performance, efficiency of transmission high, can eliminate the influence that energy that insufficient shortcoming of fixed capacity button cell and unicoil wireless energy supply possibly occur is supplied with breakthrough in vivo in the implant system; (7) for diameter is 0.38mm, length is the impulse conduit of 8cm, and this device is accomplished and conducted the blood pressure pressure signal to pressure transducer; Its head end is the pilot gel of 6mm length; And increasing heparin sodium with anticoagulation, the rear end is a pure water, accomplishes the conduction of pressure signal jointly; (8) blood pressure pressure transducer includes blood pressure sensing core body, impulse conduit mounting interface, pressure sensor interface parts, and the sensing core body adopts advanced sensing technology, and the device bridge is than the big 50K ohm of resistance fourth will; (9) amplification of blood pressure signal conditioning calibration circuit portion, that mainly carries out is the amplification conditioning of faint blood pressure signal and carries out self calibration; (10) A/D converter, (11) super low-power consumption MCU realizes control, data acquisition and designed filters and signal processing to system; (12) ultra-low power consumption wireless transceiver module comprises oscillating circuit, radiating circuit and receiving circuit, and operating frequency can be stablized blood pressure signal in the emitter in the ISM scope under the low-power consumption situation; (13) for also adopting, transmitting coil reduces volumetric spaces around coiling.
Fig. 2 is special-purpose implanted pressure transducer sketch map
This special use implanted blood pressure sensor-based system has (1) PCB welded plate, and these parts have external welding pin, and spun gold is bound pin, pressure conditioning treatment circuit; (2) external circuits welding pin is used for assembling and connects other electric components of capsule; (3) the silicon pressure drag sensing core body of customization, the core body volume is L*W=1.8mm*1.1mm, and this structure adopts special use to mix full-bridge silicon pressure drag, and bridge increases to 50K than resistance, and solder side and pressure-sensitive face are convenient to encapsulation and binding not on a face; (4) spun gold binding line is used to bind sensing core body pin to pcb board; (5) binding line protection glue-line, this protective layer adopt special-purpose colloid protection to bind the stable nothing of spun gold and fracture; (6) the encapsulation overcoat of aluminum making, (7) pressure-inducing nozzle, (8) encapsulation fill orifice; (6) (7) (8) are whole package parts, and diameter is the circle of 5mm, and the bottom is empty to place parts such as pcb board and sensing core body, and upper design has pressure-inducing nozzle and encapsulation fill orifice, to realize the warehouse of pouring water between sensing core body and the shell; (9) be dabbling water pilot liquid, (10) are the PE pipe of 0.38mm for external diameter, and length is 8cm; (11) pilot gel, and increase anti-blood-clotting agent; This device pours into pilot liquid through (8) number hole toward cavity body and conduit (9) after the installation and seal operation of accomplishing binding, connecting pipe, and head end (10) encapsulation pilot gel, after accomplishing this step, seals (8) number hole.
The specific embodiment
Step 1: the subcutaneous implant surgery of meticulous surgery: ultra micro small size body is implanted into monitoring of blood pressure miniature electronic capsule and carries out meticulous surgical operation with the implant intraperitoneal by medical personnel; Comprise anesthesia back tracheal intubation, respirator assisted respiartion, meticulous open chest surgery; Catheter pressure lay the healing with vascular wound; The pass breast is sewed up, and carries out intraperitoneal through the fixing stitching mouth of surgical operation capsule and fixes suture operation and necessary surgical procedure; Infect with antibiotic prophylaxis, guarantee that electronic capsule does not produce rejection, infection, adhesion, blood coagulation, haemolysis, nontoxic in vivo.
Step 2 a: week after delicate procedure is accomplished; Under natural physiological status; Open computer control system the electronic capsule system is started working, blood pressure parameter in the wireless telemetering body under naturalness, monitoring physiological activity situation; Analyze each item physical signs in the body, long-term continuously effectively directly monitoring to blood pressure parameter.
Step 3: opening the capsular while of miniature electronic; Open external signal data receiving record device simultaneously, the reception that realizes the miniature electronic capsule wireless is transmitted through wireless signal receiver module, signal data processing module, signal data storage module, signal data interface module synchronous real-time, the analysis of signal store and flow to computer system through interface module; Receive implant and send signal, the efficient communication scope is at 0.5～10 meter.
Step 4: while turn-on data recording system; Receive the signal of a plurality of implants; Automatically identification implant serial number and function can receive for a plurality of implants in range of receiving simultaneously, monitoring when realizing a plurality of body; The output signal is amplified analog signal 0～5V, the exportable Computer signal Data Management Analysis system that gives.
Step 5: Computer signal Data Management Analysis system: accomplish transmission to data signal through data interface module; Data handling system is through the special-purpose software analysis data that receiving system obtained; This system accomplishes record, demonstration, storage and the tentative diagnosis to blood pressure waveform; Actual monitoring gets access to blood relevant parameters such as mean pressure, pulse frequency, blood volume and blood flow to systolic pressure, diastolic pressure; The video data result be can select, and blood pressure waveform, the preservation of data processed result and printout obtained.
Claims (4)
1. measure the method and apparatus of monitoring, the amplification conditioning calibration circuit portion (9) that comprises biocompatibility is good among Fig. 1 silica gel shell (1), three-dimensional and band automatic orientation wireless energy supply receiving system (2), chargeable road and power management module (3), rechargeable battery (4), magnetic switch (5), the blood pressure sensor-based system (8) that contains pressure conducting system and special-purpose sensing core body, blood pressure signal, A/D converter (10), super low-power consumption MCU (11), ultra-low power consumption wireless transceiver module (12), and adopt the transmitting coil (13) that reduces volumetric spaces around coiling based on super low-power consumption ultra-small volume vivo implantation type blood pressure signal for one kind; This capsule all adopts the rechargeable battery technology of radio function; Device is accomplished extraction, conduction, conditioning calibration, wireless receiving and dispatching and the transmission of blood pressure signal, long term monitoring blood pressure signal.
2. the method and apparatus that super low-power consumption ultra-small volume vivo implantation type blood pressure signal according to claim 1 is measured and monitored is characterized in that its profile is a capsule-type, and overall dimensions is ∮ 9.5mm * 13.8mm.
3. the method and apparatus that super low-power consumption ultra-small volume vivo implantation type blood pressure signal according to claim 1 is measured and monitored; It is characterized in that comprising special-purpose implanted blood pressure sensor-based system among Fig. 2; This sensor-based system is after the installation and seal operation of accomplishing binding, connecting pipe; Through catheter perfusion pilot liquid and encapsulation pilot gel, to realize direct conduction to blood pressure signal.
4. the method and apparatus that super low-power consumption ultra-small volume vivo implantation type blood pressure signal according to claim 1 is measured and monitored; It is characterized in that using the capsular blood pressure sensor-based system of miniature electronic to accomplish conduction to blood pressure signal; The collection of the signal of super low-power consumption, special-purpose low-consumption wireless communication system; External signal data receiving record instrument system carries out the reception adjustment of data signal and handles storage; Carry out special-purpose software data analysis and monitoring for Computer signal Data Management Analysis system through interface module; Long-term under the physiological status of nature, safety, stable, directly monitor systolic pressure, diastolic pressure, obtain mean pressure, pulse frequency, blood volume and blood flow relevant parameter, and accomplish the demonstration of blood pressure waveform; Storage, printout.
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| CN2010105797106A CN102485167A (en) | 2010-12-01 | 2010-12-01 | Ultramicro implantation type blood pressure measuring and monitoring method and device |
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| CN2010105797106A CN102485167A (en) | 2010-12-01 | 2010-12-01 | Ultramicro implantation type blood pressure measuring and monitoring method and device |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104970757A (en) * | 2014-04-03 | 2015-10-14 | 宁波贝思转化医学研究中心有限公司 | Implantable wireless gastroenteric function detection system and usage method thereof |
| CN106492336A (en) * | 2016-12-12 | 2017-03-15 | 成都育芽科技有限公司 | A kind of blood vessel wireless charging robot |
| CN106510670A (en) * | 2016-11-28 | 2017-03-22 | 西安交通大学 | Implanted wireless passive blood pressure monitoring device not inserted in blood vessel and method |
| CN107174237A (en) * | 2017-07-07 | 2017-09-19 | 山东科技大学 | A kind of wearable electrocardiograph monitoring device of personnel in the pit |
| CN107669269A (en) * | 2017-10-21 | 2018-02-09 | 深圳市诺维思恩生物科技有限公司 | A kind of low power consumption and small volume vivo implantation type stomach physiologic parameter monitoring device and method |
| CN111528808A (en) * | 2020-05-29 | 2020-08-14 | 重庆高铂瑞骐科技开发有限公司 | Medical bionic detection probe and preparation method thereof |
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| US6533733B1 (en) * | 1999-09-24 | 2003-03-18 | Ut-Battelle, Llc | Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring |
| CN101810473A (en) * | 2009-02-25 | 2010-08-25 | 张希华 | Ultra-micro power consumption implanted wireless remote-measuring system |
| CN101856540A (en) * | 2009-04-10 | 2010-10-13 | 张希华 | Implanted telemetering stimulating system based on wireless power transmission and two-way communication |
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- 2010-12-01 CN CN2010105797106A patent/CN102485167A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6533733B1 (en) * | 1999-09-24 | 2003-03-18 | Ut-Battelle, Llc | Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring |
| CN101810473A (en) * | 2009-02-25 | 2010-08-25 | 张希华 | Ultra-micro power consumption implanted wireless remote-measuring system |
| CN101856540A (en) * | 2009-04-10 | 2010-10-13 | 张希华 | Implanted telemetering stimulating system based on wireless power transmission and two-way communication |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104970757A (en) * | 2014-04-03 | 2015-10-14 | 宁波贝思转化医学研究中心有限公司 | Implantable wireless gastroenteric function detection system and usage method thereof |
| CN106510670A (en) * | 2016-11-28 | 2017-03-22 | 西安交通大学 | Implanted wireless passive blood pressure monitoring device not inserted in blood vessel and method |
| CN106492336A (en) * | 2016-12-12 | 2017-03-15 | 成都育芽科技有限公司 | A kind of blood vessel wireless charging robot |
| CN107174237A (en) * | 2017-07-07 | 2017-09-19 | 山东科技大学 | A kind of wearable electrocardiograph monitoring device of personnel in the pit |
| CN107669269A (en) * | 2017-10-21 | 2018-02-09 | 深圳市诺维思恩生物科技有限公司 | A kind of low power consumption and small volume vivo implantation type stomach physiologic parameter monitoring device and method |
| CN111528808A (en) * | 2020-05-29 | 2020-08-14 | 重庆高铂瑞骐科技开发有限公司 | Medical bionic detection probe and preparation method thereof |
| CN111528808B (en) * | 2020-05-29 | 2022-12-23 | 重庆高铂瑞骐科技开发有限公司 | Medical bionic detection probe and preparation method thereof |
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Application publication date: 20120606 |