CN102495091A - High-flexibility nuclear magnetic resonance detection chip - Google Patents
High-flexibility nuclear magnetic resonance detection chip Download PDFInfo
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- CN102495091A CN102495091A CN2011104001508A CN201110400150A CN102495091A CN 102495091 A CN102495091 A CN 102495091A CN 2011104001508 A CN2011104001508 A CN 2011104001508A CN 201110400150 A CN201110400150 A CN 201110400150A CN 102495091 A CN102495091 A CN 102495091A
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Abstract
The invention relates to a high-flexibility nuclear magnetic resonance detection chip, comprising a matrix substrate (101), a conductive layer (102), an insulating layer (105), and a sample detection region, wherein the conductive layer (102) and the insulating layer (105) are arranged on the matrix substrate; the conductive layer contains at least one geometrical groove (104) and the conductive layer around the geometrical groove is made of graphene; a detection sample is located in the geometrical groove (104) or a right upper side (106) of the geometrical groove (104) or a micro-nano flow channel (107) of the matrix substrate at the right lower side of the geometrical groove; the conductive layer is a single whole plane geometrical structure or spliced by a plurality of plane geometrical structures. According to the invention, the nuclear magnetic resonance detection chip takes the graphene as the material so that the capacity of a test sample can reach a micro-nano size; and the test sample is close to the detection area, so that the high-flexibility nuclear magnetic resonance detection chip has very high flexibility and resolution ratio when being applied to detecting the sample with the micro-nano size.
Description
Technical field
The present invention relates to a kind of nuclear magnetic resonance detection chip, particularly a kind of high sensitivity nuclear magnetic resonance detection chip.
Background technology
At present, the pattern detection problem of high sensitivity, high-resolution micro nanoscale has obtained extensive concern and application demand.Based on the laser-Induced Fluorescence Detection of optical detection only be applicable to have the natural fluorescence characteristic or can with the interactional molecule particle of fluorescent powder, do not satisfy this requirement and most of biomolecule and compound are strict.Simultaneously, optical detecting method has the visual demand of sense channel to area-of-interest and has also limited the pick-up unit material chosen in testing process.In addition, most of optical detecting method only is confined to the analysis to known compound.Though have higher sensitivity based on electrochemical detection means, cause the nonreversibility that detects sample to destroy easily.
The detection principle of nuclear magnetic resonance technique has determined it to have its unique non-destructive, has online detection and the function of sample morphology to be detected and function assessment information is provided simultaneously, can be good at overcoming above problem.But magnetic resonance detection is because the restriction of its resolution and sensitivity has restricted its application in the micro-nano-scale pattern detection at present.
Summary of the invention
Technical matters:In order to overcome the deficiency that exists in the prior art, the present invention provides a kind of high sensitivity nuclear magnetic resonance detection chip, is applied to the detection of micro-nano-scale sample.
Technical scheme:A kind of high sensitivity nuclear magnetic resonance detection chip; Comprise a host substrate, place conductive layer and insulation course on the host substrate; And the sample detection zone, wherein: contain at least one how much groove in the said conductive layer, how much groove periphery conductive are Graphene.
Said conductive layer is single integral planar geometry, perhaps is spliced by 2 above planar geometry.
The material of said conductive layer also comprises copper or silver or Kufil, and described copper or silver or Kufil dock with the Graphene of how much groove peripheries.
Said how much groove shape are rectangle, ellipse, circle.
Said host substrate is a single layer structure, and the pattern detection zone is positioned at directly over how much grooves of conductive layer or the surface.
Said host substrate is a sandwich construction, and every layer material is identical or different in the sandwich construction, in conductive layer, under how much groove location a micro-nano runner is set, and the pattern detection zone is arranged in the micro-nano runner.
Said host substrate material is the insulating material with low-k.
Said host substrate material is quartzy or glass.
Online preparation forms conductive layer on host substrate surface, and perhaps the conductive layer that will prepare completion of the means through off-line is transferred to the host substrate surface.
Description of drawings
Fig. 1 is the vertical view of first instance of the present invention;
Fig. 2 is an A-A cut-open view among Fig. 1;
Fig. 3 is the front view of second instance of the present invention;
Fig. 4 is the vertical view of the 3rd instance of the present invention;
Fig. 5 is the vertical view of the 4th instance of the present invention;
Fig. 6 is the vertical view of the 5th instance of the present invention;
Wherein: 101: host substrate, 102,103: conductive layer, 104: how much grooves, 105: insulation course, 106: sample detection zone, 107: the micro-nano runner.
Embodiment
Below in conjunction with accompanying drawing the present invention is done explanation further.
Embodiment 1:
Like Fig. 1, shown in Figure 2, a kind of high sensitivity nuclear magnetic resonance of the present invention detection chip comprises host substrate 101, conductive layer, insulation course 105.Conductive layer 102,103 is spliced by planar geometry, and the material of host substrate 101 is a glass, also can have the material than low-k for other.Conductive layer is formed by two kinds of combinations of materials; Conductive layer 102 is the planar structure of a symmetry; Material is that copper also can be other high conductivity material; How much grooves 104 of a rectangle are arranged on conductive layer 103 planar structures, and the material that is provided with the conductive layer 103 of how much grooves 104 is a Graphene, spin coating one layer insulating 105 on the conductive layer.
As a kind of high sensitivity nuclear magnetic resonance detection chip instance of the present invention; Sample can insert how much grooves 104 directly in the sample detection zone 106; Also can insert in how much grooves 104 of rectangle; Cooperate nmr magnet, nuclear magnetic resonance spectrometer, the high sensitivity, the high-resolution that are used for the micro-nano-scale sample detect.
Embodiment 2:
Fig. 3 is the front view of second instance of the present invention, and a kind of high sensitivity nuclear magnetic resonance detection chip comprises host substrate 101, conductive layer, insulation course 105.Conductive layer is single integral planar geometry 102, and material all is a Graphene, and the conductive layer planar structure is provided with how much grooves 104 of a rectangle.Host substrate 101 is a three-decker, and a micro-nano runner 107 is arranged on the middle layer, is used for carrying detecting sample, and the material of host substrate 101 is quartzy, also can have the material than low-k for other.Spin coating one layer insulating 105 on the conductive layer.
Embodiment 3:
Fig. 4 is the vertical view of the 3rd instance of the present invention, and conductive layer 102 is single integral planar structure, and material is that graphite is rare, and how much grooves 104 are oval.
Embodiment 4:
Fig. 5 is the vertical view of the 4th instance of the present invention; Conductive layer 102,103 is spliced by planar geometry; Conductive layer 102 is two ends conductive layer planar structures, and material is a Graphene, also can be other high conductivity material copper or silver; Conductive layer 103 is provided with a runway circular geometry groove 104, and the material that is provided with the conductive layer 103 of how much grooves 104 is a Graphene.
Embodiment 5:
Fig. 6 is the vertical view of the 5th instance of the present invention; Conductive layer 103 has two how much parallel grooves 104, and conductive layer 102 is two ends conductive layer planar structures, and material is a Graphene; Also can be other high conductivity material copper or silver, the material of conductive layer 103 is a Graphene.
The above only is a preferred implementation of the present invention; Be noted that for those skilled in the art; Under the prerequisite that does not break away from the principle of the invention, can also make some improvement and retouching, these improvement and retouching also should be regarded as protection scope of the present invention.
Claims (9)
1. high sensitivity nuclear magnetic resonance detection chip; Comprise a host substrate, place conductive layer and insulation course on the host substrate; And the sample detection zone, it is characterized in that: contain at least one how much groove in the said conductive layer, how much groove periphery conductive are Graphene.
2. a kind of high sensitivity nuclear magnetic resonance detection chip according to claim 1 is characterized in that: said conductive layer is single integral planar geometry, perhaps is spliced by 2 above planar geometry.
3. a kind of high sensitivity nuclear magnetic resonance detection chip according to claim 2, it is characterized in that: the material of said conductive layer also comprises copper or silver or Kufil, described copper or silver or Kufil dock with the Graphene of how much groove peripheries.
4. a kind of high sensitivity nuclear magnetic resonance detection chip according to claim 1 is characterized in that: said how much groove shape are rectangle, ellipse, circle.
5. a kind of high sensitivity nuclear magnetic resonance detection chip according to claim 1, it is characterized in that: said host substrate is a single layer structure, the pattern detection zone is positioned at directly over how much grooves of conductive layer or the surface.
6. a kind of high sensitivity nuclear magnetic resonance detection chip according to claim 1; It is characterized in that: said host substrate is a sandwich construction; Every layer material is identical or different in the sandwich construction; In conductive layer, under how much groove location a micro-nano runner is set, the pattern detection zone is arranged in the micro-nano runner.
7. according to claim 5 or 6 described a kind of high sensitivity nuclear magnetic resonance detection chip, it is characterized in that: said host substrate material is the insulating material with low-k.
8. a kind of high sensitivity nuclear magnetic resonance detection chip according to claim 7 is characterized in that: said host substrate material is quartzy or glass.
9. a kind of high sensitivity nuclear magnetic resonance detection chip according to claim 1 is characterized in that: online preparation forms conductive layer on host substrate surface, and perhaps the conductive layer that will prepare completion of the means through off-line is transferred to the host substrate surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2011104001508A CN102495091A (en) | 2011-12-06 | 2011-12-06 | High-flexibility nuclear magnetic resonance detection chip |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011104001508A CN102495091A (en) | 2011-12-06 | 2011-12-06 | High-flexibility nuclear magnetic resonance detection chip |
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| CN102495091A true CN102495091A (en) | 2012-06-13 |
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| CN2011104001508A Pending CN102495091A (en) | 2011-12-06 | 2011-12-06 | High-flexibility nuclear magnetic resonance detection chip |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104549586A (en) * | 2015-01-14 | 2015-04-29 | 三峡大学 | Magnetic graphene based SERS (Surface Enhanced Raman Scattering) self-reference micro-fluidic chip as well as preparation method and application thereof |
Citations (5)
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| US5903198A (en) * | 1997-07-30 | 1999-05-11 | Massachusetts Institute Of Technology | Planar gyrator |
| US20050122115A1 (en) * | 2003-08-28 | 2005-06-09 | Massachusetts Institute Of Technoloy | Slitted and stubbed microstrips for high sensitivity, near-field electromagnetic detection of small samples and fields |
| US7095767B1 (en) * | 1999-08-30 | 2006-08-22 | Research Investment Network, Inc. | Near field optical apparatus |
| CN1971259A (en) * | 2006-12-06 | 2007-05-30 | 中国科学院电工研究所 | A plane NMR micro-coils micro detector |
| CN101782539A (en) * | 2010-02-05 | 2010-07-21 | 东南大学 | Microfluidic biomone detection chip based on nuclear magnetic resonance |
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2011
- 2011-12-06 CN CN2011104001508A patent/CN102495091A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5903198A (en) * | 1997-07-30 | 1999-05-11 | Massachusetts Institute Of Technology | Planar gyrator |
| US7095767B1 (en) * | 1999-08-30 | 2006-08-22 | Research Investment Network, Inc. | Near field optical apparatus |
| US20050122115A1 (en) * | 2003-08-28 | 2005-06-09 | Massachusetts Institute Of Technoloy | Slitted and stubbed microstrips for high sensitivity, near-field electromagnetic detection of small samples and fields |
| CN1971259A (en) * | 2006-12-06 | 2007-05-30 | 中国科学院电工研究所 | A plane NMR micro-coils micro detector |
| CN101782539A (en) * | 2010-02-05 | 2010-07-21 | 东南大学 | Microfluidic biomone detection chip based on nuclear magnetic resonance |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104549586A (en) * | 2015-01-14 | 2015-04-29 | 三峡大学 | Magnetic graphene based SERS (Surface Enhanced Raman Scattering) self-reference micro-fluidic chip as well as preparation method and application thereof |
| CN104549586B (en) * | 2015-01-14 | 2016-03-16 | 三峡大学 | A kind of SERS self-reference micro-fluidic chip based on magnetic graphene, its preparation method and application |
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Application publication date: 20120613 |