CN102499634A - Living human eye retina dynamic imaging device with image stabilizing function and method - Google Patents
Living human eye retina dynamic imaging device with image stabilizing function and method Download PDFInfo
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- CN102499634A CN102499634A CN2011103283776A CN201110328377A CN102499634A CN 102499634 A CN102499634 A CN 102499634A CN 2011103283776 A CN2011103283776 A CN 2011103283776A CN 201110328377 A CN201110328377 A CN 201110328377A CN 102499634 A CN102499634 A CN 102499634A
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Abstract
The invention relates to a living human eye retina dynamic imaging device with the image stabilizing function and a method, wherein the imaging device comprises a living human eye retina dynamic imaging unit, a linear confocal unit, a correction unit, a light splitting unit, a signal conversion unit and a processor. The linear confocal unit scans fundus retina in a one-dimensional way to obtain a high frame frequency image, the processor operates the image to obtain the retina jittering volume and feeds back the control voltage of the correction unit for correcting the retina jittering to the correction unit, so the connection unit can real-timely correct the retina jittering of the living human eye retina dynamic imaging unit. The invention can simultaneously obtain the high frame frequency image of the fundus retina after the linear confocal one-dimensional scanning and a jittering-free high resolution fundus retina image which is obtained via the living human eye retina dynamic imaging unit, and has the advantages of accurate retina jittering measurement, high jittering correction precision, simple system structure, good real-time performance, good stability and the like.
Description
Technical field
The invention belongs to the bio-imaging technical field of Application Optics,, can be widely used in biomedical ophthalmologic examination for a kind of living human eye retina dynamic imaging device and method with steady picture function.
Background technology
At present, to the technology of living human eye retina image-forming fundus camera, laser cofocus scanning eye-checking instrument, optical coherent chromatographic imaging etc. are arranged, they have all obtained good imaging resolution.But because the amphiblestroid physiological property of living human eye, retina vision sensitive cells is in irregular dither state always; This shake comprises multiple frequency content; About about 10-100Hz, mostly about 30Hz, imaging results not only has the interframe shake to present living human eye retina image-forming technology imaging frame frequency greatly; Also there is serious shake in the frame; If can't proofread and correct retina shake, then can't carry out Quantitative Study to retina image-forming, big limitations applying of these imaging techniques.
People such as the Zhang Yudong of Photoelectric Technology Inst., Chinese Academy of Sciences have successfully developed dynamic imager of living human eye retina (patent publication No.: CN 101926640 A); This system successfully is applied to the surface imaging field with adaptive optical technique; Adaptive optics can also pass through the real-time aberration correction of wave-front corrector by the real-time detection human eye aberration; Eliminate the picture element disperse that human eye aberration causes, obtained the high-resolution imaging result.Its system schematic is as shown in Figure 1; Illuminator provides light radiation, and this light radiation is incided on the retina along first light path, thereby and be reflected and form imaging; This imaging is propagated along second light path and is got into imaging system, and imaging system is carried out to picture to retina certain depth zone.System also comprises control device; Control device produces modulation signal and synchronizing signal is controlled illuminator and imaging system; Make illuminator send pulsed light according to modulation signal; And imaging system cooperates this pulsed light synchronously continuous imaging to be carried out on the experimenter optical fundus according to synchronizing signal, obtains living human eye retina real-time video or image sequence with direct collection.This dynamic imager of living human eye retina, imaging effect is good, but still there is defective in himself: because the mode that employing face illumination dough-making powder is surveyed; There is not shake in the frame, but because data volume is big, the IMAQ limited speed; The frame frequency speed of imaging is little; The interframe shake can't be eliminated, and this defective has limited its application inevitably, has particularly hindered it and directly has been used for the inspection of ophthalmic diseases.
Be directed to the retina interframe jitter problem that the surface imaging low frame rate causes, people such as the Shi Guohua of Photoelectric Technology Inst., Chinese Academy of Sciences have proposed based on the confocal system of line sweep and method (number of patent application: 201010595574.X and 201010595587.7).The device sketch map that patent is announced as shown in Figures 2 and 3; The outgoing beam warp optical beam transformation device of LASER Light Source is transformed to the one dimension Line beam; By scanning galvanometer scanning illumination human eye optical fundus; The imaging line light beam that goes out from fundus reflex returns the entering image-generating unit along former road, and obtains the real time imaging on human eye optical fundus through data acquisition and signal Synchronization.This line sweep confocal system adopts the one dimension line sweep to the optical fundus retina image-forming; Compare and adopt the confocal laser ophthalmoscope of spot scan; Only use a scanning galvanometer scanning line beam lighting optical fundus, imaging frame frequency is big, and shake significantly reduces in the retina frame; Can extract the interframe shake through imaging results being carried out computing, make that proofreading and correct the retina shake becomes possibility.
Summary of the invention
Technology of the present invention is dealt with problems: the weak point that overcomes above-mentioned prior art; A kind of living human eye retina dynamic imaging device and method with steady picture function is provided; Can obtain the amphiblestroid high frame frequency in the confocal optical fundus of line, big view field imaging and the amphiblestroid small field of view in dynamic imager of living human eye retina optical fundus simultaneously, not have shake, high-resolution imaging, the present invention have the retina jitter measurement accurately, high, the advantages such as system structure is simple, real-time performance good, good stability of jitter correction precision.
Technical scheme of the present invention: a kind of living human eye retina dynamic imaging device with steady picture function comprises: correcting unit, spectrophotometric unit, dynamic imager of living human eye retina unit, the confocal unit of line, signal conversion unit and datatron;
Correcting unit links to each other with signal conversion unit, dynamic imager of living human eye retina unit and spectrophotometric unit; Correcting unit is made up of tilting mirror and 4f battery of lens; The control Control of Voltage tilting mirror that signal conversion unit is exported is modulated the imaging beam of dynamic imager of living human eye retina unit output and is proofreaied and correct the retina shake, and beam split cell illumination human eye optical fundus is crossed in the imaging beam direct transmission behind the 4f battery of lens that is tilted after mirror is modulated;
Spectrophotometric unit links to each other with correcting unit, the confocal unit of line and human eye; Spectrophotometric unit is dichroic beam split plain film or dichroic Amici prism; Be used for the dynamic imager of living human eye retina illuminating bundle of correcting unit outgoing directly is transmitted to intelligent's eye, arrive correcting unit from the direct transmission of the dynamic imager of living human eye retina imaging beam of human eye retina's outgoing; With will arrive human eye from the Line beam deflecting reflection of line confocal unit outgoing, from the confocal unit of Line beam deflecting reflection receiving track of human eye retina's outgoing;
The dynamic imager of living human eye retina unit links to each other with correcting unit; The dynamic imager of living human eye retina unit is a dynamic imager of living human eye retina; Be used for human eye retina's imaging; Comprise illuminator, imaging system, control device and ADAPTIVE OPTICS SYSTEMS, transmit after the calibrated cells modulate of the unitary outgoing beam of dynamic imager of living human eye retina;
The confocal unit of line links to each other with spectrophotometric unit, datatron; The confocal unit of line is a kind of line sweep confocal ophthalmoscope system or a kind of confocal ophthalmoscope of line sweep system based on laser diffraction; Be used to survey human eye retina's shake, the confocal unit pack vinculum of line light beam generation module, spectral module, scan module, image-forming module and output module.The confocal unitary emergent ray light beam of line arrives the human eye optical fundus through the spectrophotometric unit deflecting reflection, surveys imaging from the imaging line light beam that fundus reflex goes out through the confocal unit of spectrophotometric unit deflecting reflection loop line, and imaging results is exported to datatron and is used to calculate the retina shake;
Datatron links to each other with the confocal unit of line, signal conversion unit; The confocal unitary imaging results of line is exported to datatron; Datatron adopts algorithm from imaging results, to extract the retina shake, and separates to be counted as and proofread and correct the digital quantity control voltage that retina is shaken, and exports to signal conversion unit;
Signal conversion unit links to each other with datatron, correcting unit; Signal conversion unit is made up of D/A switch device and high-voltage amplifier; The digital quantity control voltage that datatron resolves the correction retina shake that obtains is converted into analog quantity through the D/A switch device, and analog quantity control voltage is transferred to correcting unit after high-voltage amplifier amplifies;
Said tilting mirror is for reflecting tilting mirror at a high speed;
Said datatron is analog control circuit or digital computer.
The living human eye retina dynamic imaging method of the steady picture of band function is characterized in that performing step is following:
Step 1; The confocal unitary emergent ray light beam of line reaches the human eye retina through the spectrophotometric unit deflecting reflection; The imaging line light beam that reflects from human eye is through the confocal unit of spectrophotometric unit deflecting reflection loop line; Imaging is surveyed to the imaging line light beam in the confocal unit of line, obtains human eye retina's high frame frequency imaging results;
Step 2, the high frame frequency imaging results of the retina that the confocal unit of processor pair line obtains is carried out computing, obtains proofreading and correct the control voltage of retina shake, and is transferred to correcting unit through signal conversion unit;
Said step 1 comprises:
Said step 2 comprises:
Said step 24 comprises:
Step 241, the control voltage of proofreading and correct the retina shake converts analog quantity through the conversion of D/A switch device into by digital quantity;
Step 242, the control voltage of analog quantity transfers to correcting unit after high-voltage amplifier amplifies.
Said step 3 comprises:
Step 31, the unitary outgoing beam of dynamic imager of living human eye retina calibrated successively unit modulated in real time and spectrophotometric unit directly are transmitted to intelligent's eyes retina;
Step 32, the imaging beam that reflects from the human eye retina are gone back to the dynamic imager of living human eye retina unit through the correcting unit synchronous reflection after the direct transmission of spectrophotometric unit;
Step 33, the dynamic imager of living human eye retina unit obtains not having the retina high-resolution imaging result of shake to surveying through the gauged imaging beam of correcting unit.
Said step 31 comprises:
Step 311, outgoing arrives spectrophotometric unit after the calibrated unit of the unitary outgoing beam of the dynamic imager of living human eye retina modulated in real time;
Step 312, the dynamic imager of living human eye retina unit direct transmission of outgoing beam of calibrated unit modulated in real time are crossed spectrophotometric unit and are arrived the human eye retina.
Said step 32 comprises:
Step 321 is crossed spectrophotometric unit arrival correcting unit from the direct transmission of imaging beam that the human eye retina reflects;
Step 322 is from the calibrated units synchronization reflected back of the imaging beam dynamic imager of living human eye retina unit that spectrophotometric unit directly transmits.
The present invention and existing living human eye retina image-forming compared with techniques have following advantage:
(1) band of the present invention surely looks like the living human eye retina dynamic imaging device and method of function, and the confocal unit of line can access the amphiblestroid high frame frequency imaging in optical fundus.
(2) band of the present invention surely looks like the living human eye retina dynamic imaging device and method of function, from the line confocal imaging result of high frame frequency, extracts the retina shake through algorithm, and the retina jitter measurement is accurate.
(3) band of the present invention surely looks like the living human eye retina dynamic imaging device and method of function, and retina jitter correction element adopts and reflects the mirror that inclines at a high speed, and correction accuracy is high, and real-time performance is good.
(4) band of the present invention surely looks like the living human eye retina dynamic imaging device and method of function; The dynamic imager of living human eye retina scanning element is through the shake of the confocal unit real-time detection of line retina; Proofread and correct the retina shake in real time through correcting unit simultaneously; Constitute real-time closed-loop control, can proofread and correct the retina shake well, obtain the amphiblestroid nothing shake in optical fundus, high-resolution imaging.
(5) band of the present invention surely looks like the living human eye retina dynamic imaging device and method of function; Only use a high speed to reflect tilting mirror and a 4f battery of lens formation correcting unit; Have simple in structure, advantages such as manufacturing is easy, good stability, be suitable for a large amount of manufacturings and extensively promote the use of.
Description of drawings
Fig. 1 is the dynamic imager of living human eye retina sketch map;
Fig. 2 is the confocal Oph system and method structure chart of a kind of line sweep;
Fig. 3 is the confocal Oph system and method light path sketch map of a kind of line sweep;
Fig. 4 is the confocal ophthalmoscope system and method for a kind of line sweep based on a laser diffraction structure chart;
Fig. 5 is the confocal ophthalmoscope system and method for a kind of line sweep based on a laser diffraction light path sketch map;
Fig. 6 surely looks like the living human eye retina dynamic imaging device and method of function for band of the present invention;
Fig. 7 surely looks like the living human eye retina dynamic imaging device and method light path sketch map of function for band of the present invention;
Among Fig. 1,1. lighting source, 2. filter lens, 3. photoswitch, 4. light beam modulation module; 5. beacon light source, 6. Wavefront sensor, 7. wave-front corrector, 8. imaging camera, 9. translation stage; 10. experimenter's eye, 11. collimating lens, 12. expand bundle light groups, the 13. bundle light groups that contract, 14. beam sizes coupling light group; 15. imaging len, 16～18. reflecting mirrors, 19～21. spectroscopes, 22. circuit systems, 23.PC machine; 24. by 5,6,7 ADAPTIVE OPTICS SYSTEMSs formed, 25. by 1,2,3,4 illuminators formed, 26. by 8,9,15 imaging systems formed, and 27. by 22,23 control system formed.
Among Fig. 7,2. spectrophotometric unit, 3. human eye, 5. tilting mirror, the 6.4f battery of lens, other labels are shown in the figure Chinese words.
The specific embodiment
As shown in Figure 6; The living human eye retina dynamic imaging device and method structural representation that surely looks like function for band of the present invention; Band of the present invention surely looks like the living human eye retina dynamic imaging device of function, comprises the confocal unit I of line, spectrophotometric unit II, dynamic imager of living human eye retina unit IV, correcting unit V, datatron VI and signal conversion unit VII.
The confocal unit I of line links to each other with spectrophotometric unit II, datatron VI; The confocal unit I of line is Chinese invention patent " the confocal Oph system and method for a kind of line sweep; application number: 201010595574.X " or Chinese invention patent " the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction; application number: 201010595587.7 ", and the confocal unit I of line comprises Line beam generation module, spectral module, scan module, image-forming module and output module.
The confocal unit I of line can adopt the confocal Oph system and method for a kind of line sweep, and the confocal Oph system of a kind of line sweep comprises Line beam generation module 1, spectral module 2, scan module 3, image-forming module 5 and output module 6, as shown in Figures 2 and 3.Line beam generation module 1 links to each other with spectral module 2; Line beam generation module 1 is made up of point source 100, collimator and extender device 110 and Line beam capture device 120; The divergent beams that point source 100 sends are exported collimated light beam after through collimator and extender device 110 collimations, and Line beam capture device 120 is that one dimension linear light bunch is sent into spectral module 2 with the collimated light beam intercepting of collimator and extender device 110 outputs; Spectral module 2 is beam split plain film or Amici prism, and the direct transmission of an one dimension Line beam part that spectral module 2 is used for Line beam generation module 1 is produced arrives scanning element 3; Scan module 3 is made up of scanning galvanometer 300 and illumination objective lens group 310; The Line beam of spectral module 2 direct outgoing passes through scanning galvanometer 300 and illumination objective lens group 310 successively; From the I outgoing of the confocal unit of line, as shown in Figure 6 then, this Line beam gets into human eye III optical fundus behind spectrophotometric unit II deflecting reflection; The imaging line light beam that returns from fundus reflex is in the confocal unit I of spectrophotometric unit II deflecting reflection loop line; Pass through illumination objective lens group 310 and scanning galvanometer 300 synchronous reflections successively to spectral module 2, spectral module 2 reflexes to image-forming module 5 with the imaging line beam deflection, and image-forming module 5 is made up of image-forming objective lens 500, cylindrical lens 510, confocal slit 520 and line detector 530; The imaging line light beam of spectral module 2 deflection outgoing passes through image-forming objective lens 500, cylindrical lens 510 and confocal slit 520 successively; Receiving track detector 530 converts the signal of telecommunication to by light intensity signal, and is transferred to output module 6, confocal slit 520 and human eye III retinal plane conjugation; The veiling glare that confocal slit 520 can be got rid of non-human eye III retinal plane gets into line detector 530, thereby realizes the high-resolution of confocal imaging principle; Output module 6 is made up of image pick-up card 600 and outut device 610, and image pick-up card 600 becomes picture signal with the electrical signal conversion of image-forming module 5 outputs, and through outut device 610 outputs; Outut device 610 links to each other with datatron VI; The retina image-forming result that outut device 610 is obtained exports to datatron VI; Datatron VI goes out the retina shake through algorithm computation, and separates the digital quantity control voltage transmission that is counted as the shake of correction retina and give signal conversion unit VII.
The confocal unit I of line also can adopt the confocal ophthalmoscope of a kind of line sweep based on laser diffraction system; The confocal ophthalmoscope of a kind of line sweep based on laser diffraction system comprises Line beam generation module 1, spectral module 2, scan module 3, image-forming module 5 and output module 6; Like Fig. 4 and shown in Figure 5; Line beam generation module 1 links to each other with spectral module 2; Line beam generation module 1 is made up of point source 100, collimator apparatus 110 and Line beam converting means 120, and the divergent beams of point source 100 are transformed to collimated light beam through collimator apparatus 110, and this collimated light beam is transformed to the one dimension Line beam through Line beam converting means 120 and is transmitted to spectral module 2; Spectral module 2 is beam split plain film or Amici prism, and the direct transmission of an one dimension Line beam part that is used for Line beam generation module 1 is produced arrives scan module 3; Scan module 3 is made up of scanning galvanometer 300 and illumination objective lens 310; The Line beam of spectral module 2 direct outgoing passes through scanning galvanometer 300 and illumination objective lens 310 successively; Then from the I outgoing of the confocal unit of line; As shown in Figure 6, this Line beam gets into human eye III optical fundus behind spectrophotometric unit II deflecting reflection, and the imaging line light beam that returns from fundus reflex is in the confocal unit I of spectrophotometric unit II deflecting reflection loop line; Pass through illumination objective lens group 310 and scanning galvanometer 300 synchronous reflections successively to spectral module 2, spectral module 2 reflexes to image-forming module 5 with the imaging line beam deflection; Image-forming module 5 is made up of image-forming objective lens 500, cylindrical lens 510, confocal slit 520 and line detector 530; The imaging line light beam of spectral module 2 deflection outgoing passes through image-forming objective lens 500, cylindrical lens 510 and confocal slit 520 successively; Receiving track detector 530 converts the signal of telecommunication to by light intensity signal; And be transferred to output module 6; The veiling glare that confocal slit 520 and human eye III retinal plane conjugation, confocal slit 520 can be got rid of non-human eye III retinal plane gets into line detector 530, thereby realizes the high-resolution of confocal imaging principle; Output module 6 is made up of image pick-up card 600 and outut device 610, and image pick-up card 600 becomes picture signal with the electrical signal conversion of image-forming module 5 outputs, and through outut device 610 outputs; Outut device 610 links to each other with datatron VI; The retina image-forming result that outut device 610 is obtained exports to datatron VI; Datatron VI goes out the retina shake through algorithm computation, and separates the digital quantity control voltage transmission that is counted as the shake of correction retina and give signal conversion unit VII.
Dynamic imager of living human eye retina unit IV links to each other with correcting unit V, and is as shown in Figure 1 for Chinese invention patent " dynamic imager of living human eye retina, publication No.: CN 101926640 A ", comprises lighting source 1; Filter lens 2, photoswitch 3, light beam modulation module 4, beacon light source 5, Wavefront sensor 6; Wave-front corrector 7, imaging camera 8, translation stage 9, collimating lens 11; Expand bundle light group 12, the bundle light group 13 that contracts, beam size coupling light group 14, imaging len 15; Reflecting mirror 16～18, spectroscope 19～21, circuit system 22, PC 23; By 5,6,7 ADAPTIVE OPTICS SYSTEMSs 24 formed, by 1,2,3,4 illuminators 25 formed, by 8,9,15 imaging systems 26 formed, by 22,23 control system 27 formed.Beacon light source 5 sends beacon beam; Behind collimating lens 11 collimations; After spectroscope 19, spectroscope 20 reflections, get into correcting unit V of the present invention successively; As shown in Figure 6, the tilting mirror in the correcting unit V continues to propagate successively through 4f battery of lens, the direct transmission entering of spectrophotometric unit II human eye III through synchronous reflection to beacon beam.The beacon beam of human eye III retinal reflex is propagated through getting into dynamic imager of living human eye retina of the present invention unit IV behind 4f battery of lens in spectrophotometric unit II, the correcting unit V and the tilting mirror after human eye III outgoing successively, and is as shown in Figure 1; Particularly; The reflection beacon beam is then reflected by wave-front corrector 7 after expanding bundle light group 12 in spectroscope 20 places transmission, then through mirror 17 reflections that are reflected after the bundle light group 13 that contracts; The secondary reflection again in spectroscope 21 places; Through beam size coupling light group 14, finally get into Wavefront sensor 6 and carry out the detection of facula mass center side-play amount, detection data is sent into circuit system 22 processing and is obtained wavefront slope.On the one hand PC 23 restores full refraction of eye system wave aberration according to the wavefront slope of gained; 22 pairs of wavefront slope of circuit system are done further to calculate on the other hand; Obtain the corresponding correction time required correction signal that applies of wave aberration; And it is amplified rear drive wavefront appliance 7 real-Time Compensation because of the distored Beam Wave-Front of human eye 10 aberrations, make imaging system remain optimum state near diffraction limit resolution.Accomplish after system aberration proofreaies and correct, circuit system 22 is kept Adaptable System 24 and is worked on and notify PC 23, instrument to begin imaging immediately.Circuit system 22 produces the modulation signal of photoswitch 3 and coordinates photoswitch 3 and the synchronizing signal of imaging camera 8.This modulation signal is loaded into photoswitch 3; Photoswitch 3 transfers the control signal work of following to by initial closed condition, so the continuous light that lighting source 1 sends becomes pulsed light through filter lens 2, photoswitch 3 modulation successively; This pulsed light is through reflecting mirror 16 reflections then; Pass spectroscope 19,, thereby get into correcting unit V of the present invention again through spectroscope 20 reflections; As shown in Figure 6; Tilting mirror in the jitter corrected signal modulation correcting unit V of signal conversion unit VII output, tilting mirror is proofreaied and correct the retina shake to the imaging beam modulated in real time, and the direct transmission of 4f battery of lens, spectrophotometric unit II that imaging beam continues to propagate in the calibrated successively unit V gets into human eye III.The imaging beam of human eye III retinal reflex gets into dynamic imager of living human eye retina of the present invention unit IV propagation through 4f battery of lens in spectrophotometric unit II, the correcting unit V and tilting mirror synchronous reflection successively after human eye III outgoing, as shown in Figure 1; Particularly; The catoptric imaging light beam is then reflected by wave-front corrector 7 after expanding bundle light group 12 in spectroscope 20 places transmission, then through mirror 17 reflections that are reflected after the bundle light group 13 that contracts; The secondary reflection again in spectroscope 21 places; Until spectroscope 21 places transmission,, finally focus on imaging camera 8 target surfaces by imaging len 15 then through reflecting mirror 18 reflections.Imaging camera 8 cooperates the exposure of photoswitch synchronizing sequence according to the synchronizing signal of circuit system 22 generations, and rapid Continuous is gathered multiframe optical fundus retina high-definition picture in a period of time, and sends PC 23 to real-time video or the demonstration of dynamic image sequence.Therefore, the dynamic continuous imaging of the living human eye retina unit IV that the inventive system comprises can directly gather and obtain living human eye retina high-resolution, not have shake real-time video or image sequence demonstration.
Datatron VI links to each other with the confocal unit I of line, signal conversion unit VII; The imaging results of the confocal unit I of line is exported to datatron VI; Datatron VI extracts the retina shake from imaging results, and separates to be counted as and proofread and correct the digital quantity control voltage that retina is shaken, and exports to signal conversion unit VII;
Signal conversion unit VII links to each other with datatron VI, correcting unit V; Signal conversion unit VII is made up of D/A switch device and high-voltage amplifier; The digital quantity control voltage that datatron VI resolves the correction retina shake that obtains is converted into analog quantity through the D/A switch device, and analog quantity control voltage is transferred to correcting unit V after high-voltage amplifier amplifies.
Correcting unit V links to each other with signal conversion unit VII, dynamic imager of living human eye retina unit IV and spectrophotometric unit II; Correcting unit V is made up of tilting mirror and 4f battery of lens; Correcting unit V receives the control Control of Voltage of signal conversion unit VII output; Be transmitted to spectrophotometric unit II after the imaging beam of dynamic imager of living human eye retina unit IV modulated, realized real-time correction the retina shake.
As shown in Figure 7, band according to the invention surely looks like the living human eye retina dynamic imaging method of function, may further comprise the steps:
Step 1, the imaging line light beam of the confocal unit 1 of line reflexes to intelligent's eye 3 retinas through spectrophotometric unit 2;
Step 2, spectrophotometric unit 2 will be from the confocal unit 1 of imaging line beam deflection reflection loop line that human eye 3 retinal reflexs go out;
Step 5, the measured value of 7 pairs of retina shakes of datatron resolves, and obtains proofreading and correct the control voltage of retina shake;
Step 7, analog quantity control voltage transfers to tilting mirror 5 after high-voltage amplifier 9 amplifies;
Step 8, the imaging beam of dynamic imager of living human eye retina unit 4 directly are transmitted to intelligent's eye 3 retinas successively behind 4f battery of lens 6 and spectrophotometric unit 2 after tilting mirror 5 modulated in real time;
Step 9, the imaging beam that human eye 3 retinal reflexs return behind spectrophotometric unit 2 and 4f battery of lens 6, are gone back to dynamic imager of living human eye retina unit 4 through tilting mirror 5 synchronous reflections successively again;
As shown in Figure 7, be light path sketch map of the present invention, the solid line between the block diagram is represented the light path propagation path; Dotted line is depicted as the propagation of electrical signals path, and light beam is all propagated along system's primary optical axis, and the signal of telecommunication is propagated through the associated wiring; Be illustrative nature among the figure, do not represent real optical design parameter.
The confocal unit 1 of line is Chinese invention patent " the confocal Oph system and method for a kind of line sweep; application number: 201010595574.X " or Chinese invention patent " the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction, application number: 201010595587.7 ".
Spectrophotometric unit 2 is dichroic beam split plain film or dichroic Amici prism, adopts dichroic beam split plain film in the present embodiment.
Dynamic imager of living human eye retina unit 4 is for being Chinese invention patent " dynamic imager of living human eye retina, publication No.: CN 101926640 A ".
Tilting mirror 5 is for reflecting tilting mirror at a high speed.
4f battery of lens 6 is made up of the lens of two parfocals, and adopting two focal lengths in the present embodiment is two gummed achromats compositions of 50mm.
Datatron 7 is analog control circuit or digital computer.
The present invention does not limit to and above-mentioned instance, and persons skilled in the art can adopt numerous embodiments to realize the present invention according to content disclosed by the invention.
The present invention does not set forth part in detail and belongs to techniques well known.
Claims (10)
1. the living human eye retina dynamic imaging device of the steady picture of a band function is characterized in that: comprise correcting unit and spectrophotometric unit;
Correcting unit links to each other with signal conversion unit, dynamic imager of living human eye retina unit and spectrophotometric unit; Correcting unit is made up of tilting mirror and 4f battery of lens; The control Control of Voltage tilting mirror that signal conversion unit is exported is modulated the imaging beam of dynamic imager of living human eye retina unit output and is proofreaied and correct the retina shake, and beam split cell illumination human eye optical fundus is crossed in the imaging beam direct transmission behind the 4f battery of lens that is tilted after mirror is modulated;
Spectrophotometric unit links to each other with correcting unit, the confocal unit of line and human eye; Spectrophotometric unit is dichroic beam split plain film or dichroic Amici prism; Be used for the dynamic imager of living human eye retina illuminating bundle of correcting unit outgoing directly is transmitted to intelligent's eye, arrive correcting unit from the direct transmission of the dynamic imager of living human eye retina imaging beam of human eye retina's outgoing; With will arrive human eye from the Line beam deflecting reflection of line confocal unit outgoing, from the confocal unit of Line beam deflecting reflection receiving track of human eye retina's outgoing.
2. band according to claim 1 surely looks like the living human eye retina dynamic imaging device of function, it is characterized in that: also comprise dynamic imager of living human eye retina unit, the confocal unit of line, signal conversion unit and datatron;
The dynamic imager of living human eye retina unit links to each other with correcting unit; The dynamic imager of living human eye retina unit is a dynamic imager of living human eye retina; Be used for human eye retina's imaging; Comprise illuminator, imaging system, control device and ADAPTIVE OPTICS SYSTEMS, transmit after the calibrated cells modulate of the unitary outgoing beam of dynamic imager of living human eye retina;
The confocal unit of line links to each other with spectrophotometric unit, datatron; The confocal unit of line is used to survey human eye retina's shake; The confocal unit pack vinculum of line light beam generation module, spectral module, scan module, image-forming module and output module; The confocal unitary emergent ray light beam of line arrives the human eye optical fundus through the spectrophotometric unit deflecting reflection, surveys imaging from the imaging line light beam that fundus reflex goes out through the confocal unit of spectrophotometric unit deflecting reflection loop line, and imaging results is exported to datatron and is used to calculate the retina shake;
Datatron links to each other with the confocal unit of line, signal conversion unit; The confocal unitary imaging results of line is exported to datatron; Datatron adopts algorithm from imaging results, to extract the retina shake, and separates to be counted as and proofread and correct the digital quantity control voltage that retina is shaken, and exports to signal conversion unit;
Signal conversion unit links to each other with datatron, correcting unit; Signal conversion unit is made up of D/A switch device and high-voltage amplifier; The digital quantity control voltage that datatron resolves the correction retina shake that obtains is converted into analog quantity through the D/A switch device, and analog quantity control voltage is transferred to correcting unit after high-voltage amplifier amplifies.
3. band according to claim 1 surely looks like the living human eye retina dynamic imaging device of function, it is characterized in that: the confocal unit of said line is the confocal ophthalmoscope of an a kind of line sweep system.
4. band according to claim 1 surely looks like the living human eye retina dynamic imaging device of function, it is characterized in that: the confocal unit of said line is the confocal ophthalmoscope of a kind of line sweep based on a laser diffraction system.
5. band according to claim 1 surely looks like the living human eye retina dynamic imaging device of function, it is characterized in that: said tilting mirror is for reflecting tilting mirror at a high speed.
6. band according to claim 1 surely looks like the living human eye retina dynamic imaging device of function, and it is characterized in that: said datatron is analog control circuit or digital computer.
7. a band is characterized in that surely as the living human eye retina dynamic imaging method of function performing step is following:
Step 1; The confocal unitary emergent ray light beam of line reaches the human eye retina through the spectrophotometric unit deflecting reflection; The imaging line light beam that reflects from human eye is through the confocal unit of spectrophotometric unit deflecting reflection loop line; Imaging is surveyed to the imaging line light beam in the confocal unit of line, obtains human eye retina's high frame frequency imaging results;
Step 2, the high frame frequency imaging results of the retina that the confocal unit of processor pair line obtains is carried out computing, obtains proofreading and correct the control voltage of retina shake, and is transferred to correcting unit through signal conversion unit;
Step 3; The unitary outgoing beam of dynamic imager of living human eye retina calibrated unit modulated in real time is after spectrophotometric unit directly shines intelligent's eyes retina; The imaging beam that reflects from human eye is transmitted to correcting unit after the direct transmission of spectrophotometric unit; Correcting unit goes back to the imaging beam synchronous reflection to the dynamic imager of living human eye retina unit and surveys imaging, obtains amphiblestroid nothing shake high-resolution imaging;
Said step 1 comprises:
Step 11, the confocal unit of line emergent ray light beam arrives the human eye retina through the spectrophotometric unit deflecting reflection;
Step 12, the imaging line light beam that reflects from the human eye retina is through the confocal unit of spectrophotometric unit deflecting reflection loop line;
Step 13, the confocal unit of line is surveyed the imaging line light beam, obtains human eye retina's high frame frequency imaging results;
Said step 2 comprises:
Step 21, the imaging results that the confocal unit of processor pair line obtains is carried out computing, obtains the measured value of retina shake;
Step 22, the measured value of processor pair retina shake resolves, and obtains proofreading and correct the control voltage of retina shake;
Step 23, the control voltage of the positive retina shake of datatron high-ranking officers is exported to signal conversion unit;
Step 24, control voltage is transferred to correcting unit after the signal conversion unit conversion;
Said step 24 comprises:
Step 241, the control voltage of proofreading and correct the retina shake converts analog quantity through the conversion of D/A switch device into by digital quantity;
Step 242, the control voltage of analog quantity transfers to correcting unit after high-voltage amplifier amplifies;
Said step 3 comprises:
Step 31, the unitary outgoing beam of dynamic imager of living human eye retina calibrated successively unit modulated in real time and spectrophotometric unit directly are transmitted to intelligent's eyes retina;
Step 32, the imaging beam that reflects from the human eye retina are gone back to the dynamic imager of living human eye retina unit through the correcting unit synchronous reflection after the direct transmission of spectrophotometric unit;
Step 33, the dynamic imager of living human eye retina unit obtains not having the retina high-resolution imaging result of shake to surveying through the gauged imaging beam of correcting unit;
Said step 31 comprises:
Step 311, outgoing arrives spectrophotometric unit after the calibrated unit of the unitary outgoing beam of the dynamic imager of living human eye retina modulated in real time;
Step 312, the dynamic imager of living human eye retina unit direct transmission of outgoing beam of calibrated unit modulated in real time are crossed spectrophotometric unit and are arrived the human eye retina;
Said step 32 comprises:
Step 321 is crossed spectrophotometric unit arrival correcting unit from the direct transmission of imaging beam that the human eye retina reflects;
Step 322 is from the calibrated units synchronization reflected back of the imaging beam dynamic imager of living human eye retina unit that spectrophotometric unit directly transmits.
8. band according to claim 7 surely looks like the living human eye retina dynamic imaging method of function, it is characterized in that:
Said correcting unit is made up of tilting mirror and 4f battery of lens, and tilting mirror is for reflecting tilting mirror at a high speed;
Said spectrophotometric unit is dichroic beam split plain film or dichroic Amici prism;
Said datatron is analog control circuit or digital computer;
Said signal conversion unit is D/A switch device and high-voltage amplifier;
Said dynamic imager of living human eye retina unit is a dynamic imager of living human eye retina, is used for human eye retina's imaging, comprises illuminator, imaging system, control device and ADAPTIVE OPTICS SYSTEMS;
The confocal unit of said line is used to survey human eye retina's shake, comprises Line beam generation module, spectral module, scan module, image-forming module and output module.
9. band according to claim 7 surely looks like the living human eye retina dynamic imaging method of function, it is characterized in that: the confocal unit of said line is the confocal Oph system of a kind of line sweep.
10. band according to claim 7 surely looks like the living human eye retina dynamic imaging method of function, it is characterized in that: the confocal unit of said line is the confocal ophthalmoscope of a kind of line sweep based on a laser diffraction system.
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