CN102697555A - Multi-electrode hypertension endovascular radio-frequency ablation catheter - Google Patents
Multi-electrode hypertension endovascular radio-frequency ablation catheter Download PDFInfo
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- CN102697555A CN102697555A CN2012101868597A CN201210186859A CN102697555A CN 102697555 A CN102697555 A CN 102697555A CN 2012101868597 A CN2012101868597 A CN 2012101868597A CN 201210186859 A CN201210186859 A CN 201210186859A CN 102697555 A CN102697555 A CN 102697555A
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Abstract
The invention discloses a multi-electrode hypertension endovascular radio-frequency ablation catheter. The catheter comprises a connector, a handle, a catheter tube and a plurality of electrodes; one end of the catheter body is connected with the connector, and a plurality of electrodes are arranged at the other end of the catheter body; the handle is arranged at one end of the catheter tube, which is close to the connector; the electrodes are distributed at angles and along a linear longitudinal axis; a catheter main body is the catheter body which is made by compounding a thermoplastic polymer and a wire mesh, wherein the near end of the catheter body is hard, and the far end of the catheter body is soft; a far end electrode made of a platinum composite material is arranged at the front end of the catheter; and a plurality of leads of the electrodes are connected with the connector through a channel in the catheter body. The catheter has the functions of monitoring temperature of renal vascular tissues and measuring local impedance of the renal vascular tissues, has the effects of feeding back and regulating radio-frequency current intensity, retarding bilateral renal sympathetic nerves and blocking the sympathetic nerves from stimulating the kidney to produce and secrete rennin, namely angiotensin, and fulfills the aims of reducing blood pressure and treating hypertension.
Description
Technical field
The present invention relates to a kind of hypertensive conduit of clinical treatment that is applied to, radiofrequency ablation therapy conduit in particularly a kind of multipole hypertension blood vessel.
Background technology
Hypertension is to have a strong impact on people's life quality and life-threatening common disease, also be the whole world cause dead main diseases because of, the annual whole world 7 million peoples are dead because of hypertension.Point out in " the Chinese residents nutrition and the investigation of health conditions report " of issuing in information office of State Council on the 12nd news briefing October in 2004: China adult hypertension prevalence is 18.8%, and crowd's hypertension awareness, treatment rate and control rate are merely 30.2%, 24.7% and 6.1%.Even in the U.S., the control rate of hypertension treatment in recent years is less than 30% also.Yet treatment, domestic in recent years Epidemiological study show that men and women's prevalence all surpasses more than 20%; China is one of the most serious country of hypertension harm in the world at present; Estimate that national hyperpietic surpasses 200,000,000, in the international coverage, the whole world has 1,000,000,000 people to suffer from hypertension at present; Expecting hyperpietic in 2025 will have 30% people to suffer from hypertension, sum reach 1,500,000,000 (.This shows that hypertension has become that global range comprises that the present prevalence of China is the highest, one of the ill the most general disease of crowd, the research of hypertensive research and new treatment becomes human instant problem.
The serious consequence that hyperpietic's blood pressure increases is the infringement to the whole body vitals.Because the arterial pressure persistence raises; Cause the whole body arteriolosclerosis; Thereby the blood supply that influences histoorgan is not enough, and the lumen of vessels internal pressure raises, and the infringement that causes heart and brain, kidney is severe complications the most; And be prone to cause coronary heart disease, brain apoplexy, renal failure, and disability rate that causes and mortality rate obviously increase:
Domestic and international popular hypertension therapeutic remains Drug therapy at present.The purpose of its treatment be through drug effect in each link that causes hypertension, disturb the effect cause hypertension in the body and controlling blood pressure; Mainly be to rely on medicine on the Therapeutic Method; Wherein of greatest concern and what play a major role is calcium channel blocker, angiotensin-convertion enzyme inhibitor and angiotensin ii receptor antagonist; And two types of medicines are main after outstanding, and the effect of these back two types of medicines is all at RAS.The treatment of the Long term combined medication of such medicine, will not only need take for a long time and expensive, side effect outstanding, most importantly therapeutic effect is still undesirable.Data shows that present hypertensive treatment rate of China and control rate are merely 24.7% and 6.1%.Therefore, generally believe that the hypertension drug treatment of global range is still more because of side effect, individual variation, control rate be not still good, because of the mortality rate that hypertension causes can be in any more.
The basic cause of essential hypertension is brought out owing to the sympathetic nerve overacfivity and is kept.Radiolabel shows that the hyperpietic exists the too much noradrenaline secretion of kidney and gets into blood system.Thereby arranging interior all blood vessel, renal tubules and the juxtaglomerular apparatuses of kidney behind the sympathetic ganglion of domination kidney behind the neural entering kidney regulates renin angiotensin aldosterone system; Conversely, vasotonia speed II can increase central mechanism and the adrenal gland's ability neurotransmission that quickens SNE again.So, orthosympathetic effect causes blood pressure to increase.Thereby generally believe that at present the orthosympathetic activity of kidney is the major reason that causes essential hypertension.
External zoopery and clinical experiment confirm: blocking-up kidney sympathetic nerve; Can not cause that not only the kidney normal function lowers; And systolic pressure and diastole are all descended; This explanation, although essential hypertension has multifactor existence, the orthosympathetic activity of domination kidney and tension force are to play an important role in hypertension existence and the progress.The surgery wide excision visceral nerve operation of previously once carrying out can reduce renin secretion, do not reduce the filtration rate of kidney blood flow and glomerule, still can keep electrolytical balance.But the operation of visceral nerve blocking-up has so widely caused the complication of very high peri-operation period, and because of the sickness rate of lacking of proper care of other viscera functions after visceral nerve is removed widely also very high.The kidney transfer operation of clinical more enforcement at present then can explain well, remove the kidney nerve after, kidney still can keep power and water to separate the stable of matter.In zoopery, also observe, when hypertension, the sympathetic nervous system of kidney and body is closely related.Therefore; If can then can interrupt the effect of the rising blood pressure of RAS, simultaneously optionally at one organ level blocking-up RAS; Because the reduction of RAS vaso-active substance; It also is able to weaken to the orthosympathetic activation effect of whole body, thereby keeping under the complete prerequisite of renal function systemic blood pressure being descended, reaches the hypertensive purpose of treatment.Be that super-selective blocking-up kidney sympathetic nerve will make blood pressure drops, can avoid other unnecessary influences simultaneously bodily tissue and organ.
Summary of the invention
In order to solve the problems of the technologies described above, the present invention provides radiofrequency ablation therapy conduit in a kind of multipole hypertension blood vessel.The method that the Wicresoft that the present invention adopts gets involved; Percutaneous puncture intravascular intracavity arrives renal artery, and the bilateral renal arteries tube wall is imposed the high frequency current in short bursts, and the sympathetic nerve on the renal artery wall is destroyed; Sympathetic nerve interrupts for the domination of kidney; Feritin-angiotensin is reduced for a long time, thereby blood pressure drops reach the hypertensive effect of treatment.
The technical scheme that the present invention solves the problems of the technologies described above is: comprise joint, handle, catheter tube, a plurality of electrode; One end of said catheter tube links to each other with joint, and the other end is provided with a plurality of electrodes, and the end that catheter tube is abutted against head is provided with handle.
In the interior radiofrequency ablation therapy conduit of above-mentioned multipole hypertension blood vessel; Said catheter tube comprises conduit cavity, conduit internal layer, tinsel reinforcement net, catheter outer; Tinsel is strengthened net and is tightly held the conduit internal layer, and catheter outer and tinsel are strengthened the net fusion and covered outside it.
In the radiofrequency ablation therapy conduit, said electrode divides angle by 360 degree and distributes along the straight line longitudinal axis in the above-mentioned multipole hypertension blood vessel.
In the radiofrequency ablation therapy conduit, said electrodes use platinum composite or other conducting metal are made in the above-mentioned multipole hypertension blood vessel, and an end of NiTi position line links to each other with electrode, and the other end of NiTi position line links to each other with joint through conduit cavity.
In the radiofrequency ablation therapy conduit, be provided with thermocouple in the said electricity in the above-mentioned multipole hypertension blood vessel, the lead of thermocouple output in conduit cavity received joint.
In the radiofrequency ablation therapy conduit, be provided with the lead that transmits radiofrequency signal and impedance measuring in the said conduit cavity in the above-mentioned multipole hypertension blood vessel, one of the lead of biography transmission radiofrequency signal and impedance measuring terminates to joint, and the other end is received the solder joint in the electrode.
Ultimum Ti with memory performance is housed in each electrode to distribute and can attach the renal artery inwall suitably when this conduit self-aiming conduit release to guarantee that angle is correct.
Technique effect of the present invention is: 1) the NiTi position line with memory performance is equipped with in the present invention in each electrode, can guarantee the correct distribution of angle like this and when this conduit self-aiming conduit is released, can attach the renal artery inwall suitably.2) catheter tube of the present invention be divided into harder proximal segment and softer distal ports, be convenient to conduit propelling movement in vivo like this.2) proximal segment adopts the polymer of high rigidity, and handle is convenient to propelling movement, tractive or rotation, with regulate that conduit moves in blood vessel and towards.The efficient electric isolated tube of 3) packing in the body passage of the present invention guarantees the transmission of the signal of telecommunication, and the calibration and disposable that ablation site both had been convenient in multipole design melts a side kidney sympathetic nerve, can reduce or avoid melting the complication of back renal artery stenosis again.
Description of drawings
Fig. 1 is the structure chart of four electrode hypertension endovascular treatment RF therapy conduits among the present invention.
Fig. 2 is the structure chart of six electrode hypertension endovascular treatment RF therapy conduits among the present invention.
Fig. 3 is the cutaway view of catheter tube among the present invention.
Fig. 4 is the cut-away view of termination electrode among the present invention and connection tube thereof.
The specific embodiment
Referring to Fig. 1 and Fig. 2 figure.The present invention is followed successively by jointing 1, handle 2, catheter tube 3, electrode 4 from near-end to far-end.The electrode of Fig. 1 is four, and the electrode among Fig. 2 is six, and electrode is to distribute by 360 degree branch angles and along the straight line longitudinal axis.Multipole when being quadrupole, this calibration is that pole spacing is 90 degree; When being five utmost points, this calibration is that pole spacing is 72 degree when multipole; When being six types of severe debility disease, this calibration is that pole spacing is 60 degree when multipole.Electrode is signal of telecommunication output and collecting part, and the body rear portion is the joint and the joystick of signal of telecommunication input and output.
Referring to Fig. 3, Fig. 3 is the cutaway view of catheter tube.Catheter tube 3 comprises conduit cavity 8, conduit internal layer 7, tinsel reinforcement net 9, catheter outer 6, and tinsel is strengthened net and tightly held the conduit internal layer, and catheter outer and tinsel are strengthened the net fusion and covered outside it.Said catheter tube 3 is divided near the proximal segment of handle with near the distal ports of electrode, and proximal segment adopts the polymer of high rigidity, and distal ports adopts the low polymeric material of hardness number, and heat fuses and connects two sections and get final product.Electric isolated tube 5 through temperature-sensitive signal, impedance signal lead and radio-frequency current output is arranged in the conduit cavity interior 8.
Fig. 4 is distal end of catheter of the present invention and electrode interior structure chart.It is thus clear that the lead 10 that passes through in the electric isolated tube from thermocouple 11, the lead 14 of transmission radiofrequency signal and impedance measuring and NiTi position line 13 and solder joint 15.
Each electrode is paid single electrode according to telling the position from the conduit main shaft with the different branches of angle.Termination electrode 12 is made by platinum, platinumiridio, silver or other metals with excellent conductive performance, and lead 10, radio frequency output and impedance measuring lead 14 can adopt the wire producing with insulating properties.One end of radio frequency output and impedance measuring lead 14 is welded on the solder joint 15 of termination electrode 12, and an end of lead 10 is connected on the thermocouple 11 of temperature measuring, through the intravital electric isolated tube 5 of pipe, is welded at last on the joint 1 then.One end of NiTi position line 13 links to each other with the termination electrode 12 of electrode 4, and the other end of NiTi position line 13 links to each other with joint 1 through conduit cavity 8.
NiTi position line with memory performance is housed in each electrode among the present invention can be guaranteed the correct distribution of angle and when this conduit self-aiming conduit is released, can attach the renal artery inwall suitably.
Electrode is the renal artery stenosis of avoiding possibly causing because of the RF ablation on same plane at blood vessel except that by the angle distribution among the present invention, and each electrode can be spaced apart in 10-20 mm length scope of length overall on the renal artery longitudinal axis.It is thus clear that because 360 fens angles of electrode distribute and distribute along the renal artery longitudinal axis, after electrode self-aiming conduit was released, each electrode was rendered as the multipole distribution of bung flange shape.Handle is convenient to propelling movement, tractive or rotation, with regulate that conduit moves in blood vessel and towards.
Experiment in the animal body of the present invention: after femoral arteriography is put the conduit that stops blooding; Send into guiding catheter through this hemostasis conduit; X line DSA observes the front end that confirms guiding catheter down and arrives in the renal artery, then, hypertension endovascular treatment conduit is sent into through guiding catheter.Under X line DSA observes, when seeing conduit off guiding catheter, each electrode will automatically spring open and be attached to the renal artery inwall.Notice that each termination electrode arrives the renal artery proper site and the distribution length on the renal artery longitudinal axis is suitable.Jointing is measured the impedance of renal artery inwall to radiofrequency generator, and it is that 100 Europe are female that impedance is set in adjustment, and temperature control is set in the 55-60 degree, and the radio frequency export-restriction then multiply by electrodeplate by each electrode power 5-8 watt; When quadrupole, 5-8 watt X4=20-32 watt; During six types of severe debility disease, 5-8 watt X6=30-48 watt; So analogize, the radio frequency output time is set at 60-120 second.Renal artery is implemented to melt.After one side finishes, accomplish the same operation in the offside renal artery then.After finished both sides, radiofrequency catheter withdrawed from, and withdrawed from externally via guide wire, and local point of puncture hemostasis wrapping finishes operation.Guiding catheter is withdrawed from the collection of hypertension endovascular treatment conduit, withdraw from the hemostasis conduit, point of puncture compressing blood.
Claims (10)
1. the interior radiofrequency ablation therapy conduit of multipole hypertension blood vessel is characterized in that: comprise joint (1), handle (2), catheter tube (3), a plurality of electrode (4); One end of said catheter tube (3) links to each other with joint, and the other end is provided with a plurality of electrodes (4), and the end that catheter tube (3) is abutted against head (1) is provided with handle (2).
2. radiofrequency ablation therapy conduit in the multipole hypertension blood vessel according to claim 1; It is characterized in that: said catheter tube (3) comprises conduit cavity (8), conduit internal layer (7), tinsel reinforcement net (9), catheter outer (6); Tinsel is strengthened net (9) and is tightly held conduit internal layer (7), and catheter outer (6) merges with tinsel reinforcement net (9) and covers outside it.
3. radiofrequency ablation therapy conduit in the multipole hypertension blood vessel according to claim 1 is characterized in that: said electrode distributes by 360 degree branch angles and along the straight line longitudinal axis.
4. radiofrequency ablation therapy conduit in the multipole hypertension blood vessel according to claim 1; It is characterized in that: said electrode (4) adopts platinum composite or other conducting metal to make; One end of NiTi position line (13) links to each other with electrode (4), and the other end of NiTi position line (13) links to each other with joint (1) through conduit cavity (8).
5. radiofrequency ablation therapy conduit in the multipole hypertension blood vessel according to claim 1 is characterized in that: be provided with thermocouple (11) in the said electrode (4), the lead (10) of thermocouple (11) output in conduit cavity (8) received joint (1).
6. radiofrequency ablation therapy conduit in the multipole hypertension blood vessel according to claim 1; It is characterized in that: be provided with the lead (14) that transmits radiofrequency signal and impedance measuring in the said conduit cavity (8); One of the lead (14) of transmission radiofrequency signal and impedance measuring terminates to joint (1), and the other end is received the solder joint (15) in the electrode (4).
7. radiofrequency ablation therapy conduit in the multipole hypertension blood vessel according to claim 1 is characterized in that: when said electrode was 4, the angle between the electrode was 90 degree.
8. radiofrequency ablation therapy conduit in the multipole hypertension blood vessel according to claim 1 is characterized in that: when said electrode was 6, the angle between the electrode was 60 degree.
9. radiofrequency ablation therapy conduit in the multipole hypertension blood vessel according to claim 1; It is characterized in that: said catheter tube (3) is divided near the proximal segment of handle with near the distal ports of electrode; Proximal segment adopts the polymer of high rigidity; Distal ports adopts the low polymeric material of hardness number, and heat fuses connection and gets final product for two sections.
10. radiofrequency ablation therapy conduit in the multipole hypertension blood vessel according to claim 1; It is characterized in that: be provided with electric isolated tube (5) in the said catheter tube (3), the lead (10) that links to each other with electrode (4) all passes electric isolated tube (5) with the lead (14) that transmits radiofrequency signal and impedance measuring and links to each other with joint (1).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101868597A CN102697555A (en) | 2012-06-08 | 2012-06-08 | Multi-electrode hypertension endovascular radio-frequency ablation catheter |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101868597A CN102697555A (en) | 2012-06-08 | 2012-06-08 | Multi-electrode hypertension endovascular radio-frequency ablation catheter |
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| CN102697555A true CN102697555A (en) | 2012-10-03 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300917A (en) * | 2013-06-03 | 2013-09-18 | 吕世文 | Percutaneous coronary intervention radio frequency ablation electrode catheter |
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| US5423811A (en) * | 1992-12-01 | 1995-06-13 | Cardiac Pathways Corporation | Method for RF ablation using cooled electrode |
| US20020072740A1 (en) * | 2000-12-11 | 2002-06-13 | Scimed Life Systems, Inc. | Radio frequency ablation system |
| CN102125725A (en) * | 2011-04-06 | 2011-07-20 | 湖南依微迪医疗器械有限公司 | Catheter for endovascular treatment on hypertension |
| CN102274074A (en) * | 2011-05-03 | 2011-12-14 | 上海微创电生理医疗科技有限公司 | Multi-electrode open-type radio frequency ablation catheter |
| CN202637109U (en) * | 2012-06-08 | 2013-01-02 | 湖南依微迪医疗器械有限公司 | Multiple-electrode hypertension endovascular radiofrequency ablation treatment catheter |
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2012
- 2012-06-08 CN CN2012101868597A patent/CN102697555A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5423811A (en) * | 1992-12-01 | 1995-06-13 | Cardiac Pathways Corporation | Method for RF ablation using cooled electrode |
| US20020072740A1 (en) * | 2000-12-11 | 2002-06-13 | Scimed Life Systems, Inc. | Radio frequency ablation system |
| CN102125725A (en) * | 2011-04-06 | 2011-07-20 | 湖南依微迪医疗器械有限公司 | Catheter for endovascular treatment on hypertension |
| CN102274074A (en) * | 2011-05-03 | 2011-12-14 | 上海微创电生理医疗科技有限公司 | Multi-electrode open-type radio frequency ablation catheter |
| CN202637109U (en) * | 2012-06-08 | 2013-01-02 | 湖南依微迪医疗器械有限公司 | Multiple-electrode hypertension endovascular radiofrequency ablation treatment catheter |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300917A (en) * | 2013-06-03 | 2013-09-18 | 吕世文 | Percutaneous coronary intervention radio frequency ablation electrode catheter |
| CN103300917B (en) * | 2013-06-03 | 2016-03-23 | 吕世文 | The frequency ablation electrode catheter that percutaneous is got involved |
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Application publication date: 20121003 |