CN102716072A - Method for preparing ciprofloxacin lactate sodium chloride injection - Google Patents
Method for preparing ciprofloxacin lactate sodium chloride injection Download PDFInfo
- Publication number
- CN102716072A CN102716072A CN2012101934071A CN201210193407A CN102716072A CN 102716072 A CN102716072 A CN 102716072A CN 2012101934071 A CN2012101934071 A CN 2012101934071A CN 201210193407 A CN201210193407 A CN 201210193407A CN 102716072 A CN102716072 A CN 102716072A
- Authority
- CN
- China
- Prior art keywords
- sodium chloride
- ciprofloxacin
- injection
- solution
- lactic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NRBJWZSFNGZBFQ-UHFFFAOYSA-N 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;2-hydroxypropanoic acid Chemical compound CC(O)C(O)=O.C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 NRBJWZSFNGZBFQ-UHFFFAOYSA-N 0.000 title claims abstract description 34
- 229960004055 ciprofloxacin lactate Drugs 0.000 title claims abstract description 34
- 239000008354 sodium chloride injection Substances 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 24
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims abstract description 36
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000000243 solution Substances 0.000 claims abstract description 24
- 229960003405 ciprofloxacin Drugs 0.000 claims abstract description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 16
- 239000004310 lactic acid Substances 0.000 claims abstract description 16
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 16
- 239000007924 injection Substances 0.000 claims abstract description 14
- 238000002347 injection Methods 0.000 claims abstract description 14
- 230000001954 sterilising effect Effects 0.000 claims abstract description 14
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000008215 water for injection Substances 0.000 claims abstract description 11
- 239000011780 sodium chloride Substances 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 238000007789 sealing Methods 0.000 claims abstract description 7
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000005070 sampling Methods 0.000 claims description 7
- 238000004090 dissolution Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims description 3
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims description 3
- 229910000831 Steel Inorganic materials 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000010959 steel Substances 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 4
- 238000003912 environmental pollution Methods 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229940124274 edetate disodium Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000007689 inspection Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 12
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 238000005286 illumination Methods 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 3
- 210000004907 gland Anatomy 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 241000607528 Aeromonas hydrophila Species 0.000 description 1
- 206010069918 Bacterial prostatitis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010017964 Gastrointestinal infection Diseases 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 206010062255 Soft tissue infection Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000006374 Uterine Cervicitis Diseases 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 206010008323 cervicitis Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000019836 digestive system infectious disease Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000000688 enterotoxigenic effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 208000000143 urethritis Diseases 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
Abstract
The invention provides a method for preparing ciprofloxacin lactate sodium chloride injection, and belongs to the field of medicinal preparation. The method includes the steps: firstly, dissolving lactic acid and sodium hydroxide into water for injection to prepare lactic acid solution; secondly, sufficiently mixing ciprofloxacin serving as a raw material, edetate disodium, diluted hydrochloric acid and the water for injection to prepare ciprofloxacin solution; and finally, sufficiently mixing the prepared lactic acid solution and the prepared ciprofloxacin solution, adding sodium chloride for injection into the solution, mixing the sodium chloride with the solution, and adjusting the pH (potential of hydrogen) value, adjusting the volume, pre-filtering, degerming, filling and sealing and performing autoclaved sterilization, inspection and the like to prepare the ciprofloxacin lactate sodium chloride injection. The method has the advantages of simple and convenient process, no environmental pollution, low cost and the like, and the ciprofloxacin lactate sodium chloride injection prepared by the method is high in stability and quality.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, relate to a kind of method for preparing of medicaments injection, relate in particular to a kind of method for preparing of ciprofloxacin lactate sodium chloride injection.
Background technology
Ciprofloxacin lactate (ciprofloxacin lactate) is a synthetic high-efficiency antimicrobial medicine; Its chemical name is 1-cyclopropyl-6-fluoro-1; 4-dihydro-4-oxo-7-(1-croak throat base)-3-quinoline carboxylic acid lactate,, as third generation quinolones broad spectrum antibiotic; Its oral formulations is gone on the market in 1987 by Bayer (Bayer) company, and commodity are called Ciproxin.Its sodium chloride injection went on the market in the U.S. in nineteen ninety; Name is called CIPRO IN SODIUM CHLORIDE 0.9%IN PLASTIC CONTAINER; Be used for treatment clinically by the microbial urogenital infections of sensitivity, comprise simple property, complexity urinary tract infection, bacterial prostatitis, NEISSERIA GONORRHOEAE urethritis or cervicitis (comprise produce enzyme strain due to person).Also respiratory tract infection be can treat, bronchial infection acute attack and pulmonary infection due to the responsive gram negative bacilli comprised.The treatment gastrointestinal infection is due to Shigella, Salmonella, enterotoxigenic escherichia coli, aeromonas hydrophila, vibrio parahaemolytious etc.Also can treat systemic infection such as typhoid fever, bone and the infection of joint, skin soft-tissue infection septicemia, determined curative effect.
At present domestic ciprofloxacin lactate sodium chloride injection prepares for directly adopting the ciprofloxacin lactate crude drug.For example one Chinese patent application CN 102274169 A disclose a kind of method for preparing of ciprofloxacin lactate sodium chloride injection; Background technology partly mention since the ciprofloxacin lactate crude drug to photaesthesia; Decompose easily; And water solublity is not fine, thereby directly to adopt stability, the dissolubility of the ciprofloxacin lactate sodium chloride injection of ciprofloxacin lactate crude drug preparation all be not fine.And domestic ciprofloxacin lactate all needs ciprofloxacin is obtained through certain synthesis technique, and this not only will increase expending of a large amount of organic solvents, brings harmful effect for product quality and environmental pollution; Also increase production cost, be unfavorable for the benign development of pharmaceutical manufacturer.
Summary of the invention
Deficiency to above-mentioned prior art; The purpose of this invention is to provide a kind of directly is the method for preparing of the ciprofloxacin lactate sodium chloride injection processed of raw material with ciprofloxacin and lactic acid; This method technology is easy, non-environmental-pollution, cost are low, and the ciprofloxacin lactate sodium chloride injection that makes through this method for preparing has good stability and dissolubility.
The method for preparing of a kind of ciprofloxacin lactate sodium chloride injection of the present invention, it comprises the steps:
Step a processes the preparatory solution of lactic acid with lactic acid and dissolution of sodium hydroxide in water for injection, be prepared into required lactic acid solution through sterilization treatment again after the sealing;
Step b, successively with disodium edetate, ciprofloxacin, diluted hydrochloric acid dissolution in water for injection, fully stirring and evenly mixing is prepared into ciprofloxacin solution;
Step c behind the abundant mixing of ciprofloxacin solution with the lactic acid solution of step a gained and step b gained, adds the sodium chloride for injection stirring and evenly mixing, regulates pH value then to 3.3-4.4;
Steps d is replenished water for injection;
Step e, sampling detects pH value, sodium chloride content and ciprofloxacin content;
Step f after the assay was approved, earlier through the filter on-line filtration, carries out aseptic filtration through cartridge filter and microporous filter membrane with solution again, collects and filtrates to rustless steel container;
Step g, fill add plug and envelope aluminum lid then to vial;
Step h, with embedding is good bottle autoclaving 30 minutes under 121 ℃ condition, check promptly gets the ciprofloxacin lactate sodium chloride injection.
The present invention has also carried out preferably above-mentioned steps, and preferably, the temperature of described step a sterilization treatment is 115-125 ℃, and sterilization time is 20-40 minute; Further preferably, the temperature of described step a sterilization treatment is 121 ℃, and sterilization time is 30 minutes.
Preferably, the present invention prepares in the method for ciprofloxacin lactate sodium chloride injection, and described pH value is adjusted to 3.7-4.2.More preferably, described pH value is adjusted to 4.0.
The method for preparing of a kind of ciprofloxacin lactate sodium chloride injection provided by the invention; The stability and the solubility problem of ciprofloxacin lactate sodium chloride injection can be effectively solved, and the undesirable element that influences injection that brings because of the ciprofloxacin lactate crude drug can be avoided.
The specific embodiment
To the further explain that the present invention did, can not assert that practical implementation of the present invention is confined to these explanations below in conjunction with concrete preferred implementation.For the those of ordinary skill of technical field under the present invention, under the prerequisite that does not break away from the present invention's design, can also make some simple deduction or replace, all should be regarded as belonging to protection scope of the present invention.
Embodiment 1 ciprofloxacin lactate sodium chloride injection and preparation method thereof
Prescription:
Preparation technology:
Step a processes the preparatory solution of lactic acid with lactic acid and dissolution of sodium hydroxide in water for injection, be prepared into required lactic acid solution through sterilization treatment again after the sealing; The temperature of sterilization treatment is 121 ℃, and sterilization time is 30 minutes.
Step b, successively with disodium edetate, ciprofloxacin, diluted hydrochloric acid dissolution in water for injection, fully stirring and evenly mixing is prepared into ciprofloxacin solution;
Step c behind the abundant mixing of ciprofloxacin solution with the lactic acid solution of step a gained and step b gained, adds the sodium chloride for injection stirring and evenly mixing; Regulate pH value to 4.0 then;
Steps d is replenished water for injection;
Step e, sampling detects pH value, sodium chloride content and ciprofloxacin content;
Step f earlier through the filter on-line filtration of 5 μ m, carries out aseptic filtration through 0.2/0.22 μ m cartridge filter and 0.2/0.22 μ m microporous filter membrane with solution again, is filtered in the rustless steel container.
Step g, fill be (loading amount is controlled at 100ml-105ml) to vial, adds plug and envelope aluminum lid then;
Step h, with embedding is good bottle autoclaving 30 minutes under 121 ℃ condition, check promptly gets the ciprofloxacin lactate sodium chloride injection.
Test Example: stability study
1, hot test:
With the injection fill of embodiment 1 in the colourless transparent glass bottle, gland seal, sealing places under 60 ℃ and makes an experiment, respectively at the 5th day with sampling in the 10th day, the related item of detection injection.Result such as following table:
Table 1, hot test result
The result shows, ciprofloxacin lactate sodium chloride injection of the present invention steady quality in hot test.
2, high humility test:
In the colourless transparent glass bottle, gland seal, sealing place under 25 ℃, relative humidity 90% ± 5% condition and make an experiment with the injection fill of embodiment 1, respectively at the 5th day with sampling in the 10th day, the related item of detection injection.Result such as following table:
Table 2, high humility result of the test
The result shows, ciprofloxacin lactate sodium chloride injection of the present invention steady quality in hot test.
3, strong illumination test:
In the colourless transparent glass bottle, gland seal is the condition held 10 days of 4500 ± 500Lx in intensity of illumination, respectively at the 5th day and sampling in the 10th day, detects the related item of injection with the injection fill of embodiment 1.Result such as following table:
Table 3, illumination accelerated test result
The result shows that ciprofloxacin lactate sodium chloride injection of the present invention is steady quality in the strong illumination test.
4, accelerated test:
In the colourless transparent glass bottle, sealing places 40 ± 2 ℃ with the injection fill of embodiment 1; Carry out accelerated test under the condition of relative humidity 75% ± 5%,, detect the related item of injection respectively at the 1st, 2,3,6 sampling at the end of month.Result such as following table:
Table 4, long-term stable experiment result
The result shows, ciprofloxacin lactate sodium chloride injection of the present invention steady quality in accelerated stability test.
Claims (4)
1. the method for preparing of a ciprofloxacin lactate sodium chloride injection, it is characterized in that: it comprises the steps:
Step a processes the preparatory solution of lactic acid with lactic acid and dissolution of sodium hydroxide in water for injection, be prepared into required lactic acid solution through sterilization treatment again after the sealing;
Step b, successively with disodium edetate, ciprofloxacin, diluted hydrochloric acid dissolution in water for injection, fully stirring and evenly mixing is prepared into ciprofloxacin solution;
Step c behind the abundant mixing of ciprofloxacin solution with the lactic acid solution of step a gained and step b gained, adds the sodium chloride for injection stirring and evenly mixing; Regulate pH value then to 3.3-4.4;
Steps d is replenished water for injection;
Step e, sampling detects pH value, sodium chloride content and ciprofloxacin content;
Step f after the assay was approved, earlier through the filter on-line filtration, carries out aseptic filtration through cartridge filter and microporous filter membrane with solution again, collects and filtrates to rustless steel container;
Step g, fill add plug and envelope aluminum lid then to vial;
Step h, with embedding is good bottle autoclaving 30 minutes under 121 ℃ condition, check promptly gets the ciprofloxacin lactate sodium chloride injection.
2. the method for preparing of a kind of ciprofloxacin lactate sodium chloride injection according to claim 1 is characterized in that: the temperature of described step a sterilization treatment is 115-125 ℃, and sterilization time is 20-40 minute.
3. the method for preparing of a kind of ciprofloxacin lactate sodium chloride injection according to claim 2 is characterized in that: the temperature of described step a sterilization treatment is 121 ℃, and sterilization time is 30 minutes.
4. the method for preparing of a kind of ciprofloxacin lactate sodium chloride injection according to claim 1 is characterized in that: described pH value is adjusted to 3.7-4.2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210193407.1A CN102716072B (en) | 2012-06-13 | 2012-06-13 | Method for preparing ciprofloxacin lactate sodium chloride injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210193407.1A CN102716072B (en) | 2012-06-13 | 2012-06-13 | Method for preparing ciprofloxacin lactate sodium chloride injection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102716072A true CN102716072A (en) | 2012-10-10 |
| CN102716072B CN102716072B (en) | 2014-06-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210193407.1A Active CN102716072B (en) | 2012-06-13 | 2012-06-13 | Method for preparing ciprofloxacin lactate sodium chloride injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102716072B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106632036A (en) * | 2016-12-27 | 2017-05-10 | 河南康达制药有限公司 | Preparation method of ciprofloxacin lactate |
| CN108938636A (en) * | 2018-09-10 | 2018-12-07 | 贵州天地药业有限责任公司 | A kind of preparation method of Ciprofloxacin Lactate and Sodium Chloride Injection |
| CN114767627A (en) * | 2022-05-17 | 2022-07-22 | 广州南鑫药业有限公司 | Preparation method of ciprofloxacin lactate and sodium chloride injection |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87100728A (en) * | 1985-10-24 | 1988-08-31 | 拜尔公司 | 1-cyclopropyl-6-fluoro-1, the infusion solution of 4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid |
| US5023257A (en) * | 1988-04-15 | 1991-06-11 | Bayer Aktiengesellschaft | Intramuscular injection forms of gyrase inhibitors |
| CN1115641A (en) * | 1995-07-06 | 1996-01-31 | 东北制药总厂 | Prepn of cyclopropyloxacini injecta |
| WO2005075430A1 (en) * | 2004-02-02 | 2005-08-18 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for preparing purified ciprofloxacin |
| CN101032487A (en) * | 2006-03-07 | 2007-09-12 | 苑立超 | Levofloxacin mesylate transfusion and the preparing method |
-
2012
- 2012-06-13 CN CN201210193407.1A patent/CN102716072B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87100728A (en) * | 1985-10-24 | 1988-08-31 | 拜尔公司 | 1-cyclopropyl-6-fluoro-1, the infusion solution of 4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid |
| US5023257A (en) * | 1988-04-15 | 1991-06-11 | Bayer Aktiengesellschaft | Intramuscular injection forms of gyrase inhibitors |
| CN1115641A (en) * | 1995-07-06 | 1996-01-31 | 东北制药总厂 | Prepn of cyclopropyloxacini injecta |
| WO2005075430A1 (en) * | 2004-02-02 | 2005-08-18 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for preparing purified ciprofloxacin |
| CN101032487A (en) * | 2006-03-07 | 2007-09-12 | 苑立超 | Levofloxacin mesylate transfusion and the preparing method |
Non-Patent Citations (1)
| Title |
|---|
| 李华声，等: "乳酸环丙沙星注射液的制备工艺及探讨", 《北方牧业》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106632036A (en) * | 2016-12-27 | 2017-05-10 | 河南康达制药有限公司 | Preparation method of ciprofloxacin lactate |
| CN106632036B (en) * | 2016-12-27 | 2019-04-26 | 河南康达制药有限公司 | A kind of preparation method of Ciprofloxacin Lactate |
| CN108938636A (en) * | 2018-09-10 | 2018-12-07 | 贵州天地药业有限责任公司 | A kind of preparation method of Ciprofloxacin Lactate and Sodium Chloride Injection |
| CN114767627A (en) * | 2022-05-17 | 2022-07-22 | 广州南鑫药业有限公司 | Preparation method of ciprofloxacin lactate and sodium chloride injection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102716072B (en) | 2014-06-18 |
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