CN102764481A - Photostimulation device and method for adjusting photostimulation temperature - Google Patents
Photostimulation device and method for adjusting photostimulation temperature Download PDFInfo
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- CN102764481A CN102764481A CN2012102436209A CN201210243620A CN102764481A CN 102764481 A CN102764481 A CN 102764481A CN 2012102436209 A CN2012102436209 A CN 2012102436209A CN 201210243620 A CN201210243620 A CN 201210243620A CN 102764481 A CN102764481 A CN 102764481A
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Abstract
The invention relates to a photostimulation device which comprises a temperature sensor, a central processing unit, a drug feeding device, a refrigerating device, and a micro guide tube. The temperature sensor is used for detecting temperature of nerve tissues. The central processing unit which is connected with the temperature sensor is used for receiving feedback temperature information of the temperature sensor. The drug feeding device which is connected with the central processing unit is used for filling solution. The refrigerating device which is connected with the central processing unit and the drug feeding device are used for refrigerating the solution filled by the drug feeding device. The micro guide tube which is connected with the refrigerating device is used for conveying the refrigerated solution to the nerve tissues. The central processing unit is further used for adjusting parameters of solution filled by the drug feeding device according to the feedback temperature information of the temperature sensor and adjusting refrigerating parameters of solution refrigerated by the refrigerating device. In addition, the invention further provides a method for adjusting photostimulation temperature. By the photostimulation device and the method, radiation and cooling in the photostimulation can be achieved.
Description
Technical field
The present invention relates to medical instruments field, the method for temperature when particularly relating to a kind of light stimulation device and regulating photostimulation.
Background technology
Worldwide nervous system disease and mental sickness have become two hang-ups of current society.Comprise epilepsy, Parkinson's disease, schizophrenia, anorexia nervosa, depression, senile dementia, tremble, numerous central nervous systems of spasm, obsession, anxiety neurosis, apoplexy and drug addiction etc. mental sickness of unifying threatens human health always, puzzlement human orthobiosis.And the appearance of light genetics technology (Optogenetics) lets and makes the solution of the problems referred to above become possibility.
The light genetics technology is a biotechnology of having integrated a kind of brand-new multidisciplinary intersection of optics, genetic engineering, electric physiology and electronic engineering that was developing rapidly in recent years.Its cardinal principle is at first to adopt gene technology the light sensation gene to be transferred in the cell of particular type in the nervous system to express, and makes it on cell membrane, form special ion channel.These ion channels can be respectively to cation or anionic through producing selectivity under the photostimulation of different wave length; Cause the transmembrane potential on cell membrane both sides to change; The optionally excited or inhibition of pair cell, thus reach the purpose of treating nervous system disease and mental sickness.
Yet the light stimulation device in the conventional art is when carrying out photostimulation through fiber optic conduction light, and optical fiber can produce heat makes temperature raise gradually.And nervous tissue is responsive to temperature, can influence the therapeutic effect of photostimulation.Therefore the thermal diffusivity of the light stimulation device in the conventional art is relatively poor.
Summary of the invention
Based on this, be necessary to provide a kind of thermal diffusivity light stimulation device preferably.
A kind of light stimulation device comprises:
Temperature sensor is used to detect the temperature of nervous tissue;
Central processing unit is connected with said temperature sensor, is used to receive the temperature information of said temperature sensor feedback;
Doser is connected with said central processing unit, is used for primer solution;
Refrigerating plant is connected with said doser with central processing unit, and the dabbling solution of said doser is used to freeze;
Microtubular is connected with refrigerating plant, is used for the solution after the refrigeration is transferred to nervous tissue;
Said central processing unit also is used for adjusting according to the temperature information of said temperature sensor feedback the parameter of said doser primer solution, and adjusts said refrigerating plant solution is carried out refrigerating refrigeration parameter.
Among embodiment, also comprise therein:
Signal generator is connected with said central processing unit, is used to produce optical stimulus signal;
Light source is connected with signal generator, is used for producing light beam according to optical stimulus signal;
Optical fiber is connected with light source, is used for nervous tissue is carried out photostimulation;
Said central processing unit also is used for adjusting according to the temperature information of said temperature sensor feedback the parameter of the optical stimulus signal of said signal generator generation.
Among embodiment, said temperature sensor also comprises the piped detecting head that is used for detected temperatures therein, and said detecting head and said optical fiber, said microtubular are arranged in fascicular texture.
Among embodiment, the parameter of said optical stimulus signal comprises waveform and/or dutycycle therein.
Among embodiment, the parameter of said primer solution is a flow rate of liquid therein, and said refrigeration parameter is a refrigeration work consumption.
Therein among embodiment, said temperature sensor is at least a in thermocouple type temperature sensor, infrared temperature sensor, the nano fluorescent pick off.
Among embodiment, said master reference also is used for the temperature information buffer memory with the temperature sensor feedback that receives, and when temperature is higher than threshold value, reports to the police therein.
Method of temperature when in addition, also being necessary to provide a kind of adjusting photostimulation of the temperature can reduce photostimulation the time.
A kind of method of temperature when regulating photostimulation comprises:
Obtain the temperature information of the nervous tissue that receives photostimulation;
According to said temperature information primer solution;
According to said temperature information said dabbling solution is freezed;
Said solution is imported said nervous tissue.
Therein among embodiment, also comprise after the step of the said temperature information that obtains the nervous tissue that receives photostimulation:
Regulate optical stimulus signal according to said temperature information;
Generate light beam according to the optical stimulus signal after the said adjusting;
Through said light beam said nervous tissue is carried out photostimulation.
Therein among embodiment, said step of regulating optical stimulus signal according to said temperature information is:
Regulate the waveform and/or the dutycycle of optical stimulus signal according to said temperature information.
Above-mentioned light stimulation device; Temperature sensor, central processing unit, doser, refrigerating plant and microtubular have been added; Central processing unit can detect the temperature information of the nervous tissue that receives photostimulation through temperature sensor; And produce the lower solution of temperature according to temperature information control doser, refrigerating plant, and this solution is imported to the nervous tissue place that receives photostimulation through microtubular, thus played effect to nervous tissue's radiating and cooling.
With after signal generator is connected, central processing unit can be regulated the intensity and the duration of photostimulation according to the temperature information of temperature sensor feedback with central processing unit.For example, when temperature is higher, reduce photostimulation intensity and duration; When temperature is low, improve photostimulation intensity and duration.Thereby temperature is regulated, played the effect of cooling.
Description of drawings
Fig. 1 is the structural representation of light stimulation device among the embodiment;
Fig. 2 is the structural representation of light stimulation device among another embodiment;
Fig. 3 is the structural representation of the fascicular texture that is arranged in of temperature sensor among the embodiment, optical fiber, microtubular;
Fig. 4 is the flow chart of the method for temperature when regulating photostimulation among the embodiment.
The specific embodiment
In one embodiment; As shown in Figure 1; A kind of light stimulation device comprises: temperature sensor 102, the central processing unit 104 that is connected with temperature sensor 102, the doser 106 that is connected with central processing unit 104, the refrigerating plant 108 that is connected with doser 106 with central processing unit 104, the microtubular 110 that is connected with refrigerating plant 108.Wherein:
Doser 106 is used for primer solution.
Refrigerating plant 108 is connected with doser 106 with central processing unit 104, and doser 106 dabbling solution are used to freeze.
Microtubular 110 is used for the solution after the refrigeration is transferred to nervous tissue.
Further, temperature sensor 102 can be at least a in thermocouple type temperature sensor, infrared temperature sensor, the nano fluorescent pick off.
Further, the parameter of doser 106 primer solution is a flow rate of liquid.
Further, the refrigeration parameter of refrigerating plant 108 is a refrigeration work consumption.
Further, the dabbling solution of doser is cerebrospinal fluid.
Further, central processing unit 104 also is used for the temperature information buffer memory with the temperature sensor that receives 102 feedbacks, and when temperature is higher than threshold value, reports to the police.Can pass through luminous or sounding alarm.
Further, the certainty of measurement of temperature sensor 102 is less than 1 degree centigrade.
In one embodiment, as shown in Figure 2, light stimulation device also comprises the signal generator 112 that is connected with central processing unit 104, the light source 114 that is connected with signal generator 112, the optical fiber 116 that is connected with light source 114.Wherein:
In the present embodiment, as shown in Figure 3, temperature sensor 102 is a tubulose, and temperature sensor 102 is arranged in fascicular texture with optical fiber 114, microtubular 110.When treatment, can the tip contact nervous tissue of this fascicular texture be carried out photostimulation to nervous tissue.
Further, the parameter of optical stimulus signal comprises waveform and/or dutycycle.
Optical stimulus signal is the signal of telecommunication, and light source can produce the light beam that is used for photostimulation according to this optical stimulus signal through opto-electronic conversion.
Above-mentioned light stimulation device; Temperature sensor, central processing unit, doser, refrigerating plant and microtubular have been added; Central processing unit can detect the temperature information of the nervous tissue that receives photostimulation through temperature sensor; And produce the lower solution of temperature according to temperature information control doser, refrigerating plant, and this solution is imported to the nervous tissue place that receives photostimulation through microtubular, thus played effect to nervous tissue's radiating and cooling.
With after signal generator is connected, central processing unit can be regulated the intensity and the duration of photostimulation according to the temperature information of temperature sensor feedback with central processing unit.For example, when temperature is higher, reduce photostimulation intensity and duration; When temperature is low, improve photostimulation intensity and duration.Thereby temperature is regulated, played the effect of cooling.
In one embodiment, as shown in Figure 4, a kind of method of temperature when regulating photostimulation comprises:
Step S102 obtains the temperature information of the nervous tissue that receives photostimulation.
In one embodiment, can obtain the temperature information of the nervous tissue that receives photostimulation through temperature sensor.Temperature sensor can be at least a in thermocouple type temperature sensor, infrared temperature sensor, the nano fluorescent pick off.
Step S104 is according to the temperature information primer solution.
In one embodiment, can calculate flow rate of liquid, according to the flow rate of liquid primer solution according to temperature information.In the present embodiment, can regulate the doser primer solution according to temperature information through central processing unit.
Step S106 freezes to said dabbling solution according to said temperature information.
In one embodiment, can calculate refrigeration work consumption, dabbling solution freezed according to refrigeration work consumption according to temperature information.In the present embodiment, can regulate refrigerating plant according to temperature information through central processing unit freezes to dabbling solution.
Step S108 imports nervous tissue with solution.
In one embodiment, can solution be imported to the nervous tissue place that receives photostimulation through microtubular.
In one embodiment, the step of obtaining the temperature information of the nervous tissue that receives photostimulation also can be regulated optical stimulus signal according to temperature information afterwards; Optical stimulus signal according to after regulating generates light beam; Carry out photostimulation through light beam and to nervous tissue.
In the present embodiment, the step according to temperature information adjusting optical stimulus signal is specially: the waveform and/or the dutycycle of regulating optical stimulus signal according to temperature information.
Method of temperature during above-mentioned adjusting photostimulation is obtained the temperature information of the nervous tissue that receives photostimulation, behind temperature information perfusion and refrigeration solution, solution is imported nervous tissue, has played the effect to nervous tissue's radiating and cooling.
Simultaneously, regulate optical stimulus signal, generate light beam according to the optical stimulus signal after regulating according to temperature information; Carry out photostimulation through light beam and to nervous tissue.Make that the intensity and the duration of photostimulation can be adjusted according to temperature information, thereby played the effect of cooling further.
The above embodiment has only expressed several kinds of embodiments of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that for the person of ordinary skill of the art under the prerequisite that does not break away from the present invention's design, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with accompanying claims.
Claims (10)
1. a light stimulation device is characterized in that, comprising:
Temperature sensor is used to detect the temperature of nervous tissue;
Central processing unit is connected with said temperature sensor, is used to receive the temperature information of said temperature sensor feedback;
Doser is connected with said central processing unit, is used for primer solution;
Refrigerating plant is connected with said doser with central processing unit, and the dabbling solution of said doser is used to freeze;
Microtubular is connected with refrigerating plant, is used for the solution after the refrigeration is transferred to nervous tissue;
Said central processing unit also is used for adjusting according to the temperature information of said temperature sensor feedback the parameter of said doser primer solution, and adjusts said refrigerating plant solution is carried out refrigerating refrigeration parameter.
2. light stimulation device according to claim 1 is characterized in that, also comprises:
Signal generator is connected with said central processing unit, is used to produce optical stimulus signal;
Light source is connected with signal generator, is used for producing light beam according to optical stimulus signal;
Optical fiber is connected with light source, is used for nervous tissue is carried out photostimulation;
Said central processing unit also is used for adjusting according to the temperature information of said temperature sensor feedback the parameter of the optical stimulus signal of said signal generator generation.
3. light stimulation device according to claim 2 is characterized in that, said temperature sensor also comprises the piped detecting head that is used for detected temperatures, and said detecting head and said optical fiber, said microtubular are arranged in fascicular texture.
4. light stimulation device according to claim 2 is characterized in that the parameter of said optical stimulus signal comprises waveform and/or dutycycle.
5. light stimulation device according to claim 1 is characterized in that, the parameter of said primer solution is a flow rate of liquid, and said refrigeration parameter is a refrigeration work consumption.
6. light stimulation device according to claim 1 is characterized in that, said temperature sensor is at least a in thermocouple type temperature sensor, infrared temperature sensor, the nano fluorescent pick off.
7. light stimulation device according to claim 1 is characterized in that, said master reference also is used for the temperature information buffer memory with the temperature sensor feedback that receives, and when temperature is higher than threshold value, reports to the police.
8. method of temperature when regulating photostimulation comprises:
Obtain the temperature information of the nervous tissue that receives photostimulation;
According to said temperature information primer solution;
According to said temperature information said dabbling solution is freezed;
Said solution is imported said nervous tissue.
9. the method for temperature during adjusting photostimulation according to claim 8 is characterized in that, also comprises after the step of the said temperature information that obtains the nervous tissue that receives photostimulation:
Regulate optical stimulus signal according to said temperature information;
Generate light beam according to the optical stimulus signal after the said adjusting;
Through said light beam said nervous tissue is carried out photostimulation.
10. the method for temperature during adjusting photostimulation according to claim 9 is characterized in that, said step of regulating optical stimulus signal according to said temperature information is:
Regulate the waveform and/or the dutycycle of optical stimulus signal according to said temperature information.
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| CN102380170A (en) * | 2011-08-16 | 2012-03-21 | 中国科学院深圳先进技术研究院 | Implanted photoelectrode collecting, regulating and controlling device |
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Patent Citations (5)
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| US20030083716A1 (en) * | 2001-10-23 | 2003-05-01 | Nicolelis Miguel A.L. | Intelligent brain pacemaker for real-time monitoring and controlling of epileptic seizures |
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