CN102885648B

CN102885648B - Sympathetic nerve denervation ablation catheter system for kidneys

Info

Publication number: CN102885648B
Application number: CN201210312649.8A
Authority: CN
Inventors: 杨攀; 钟理; 宋治远; 廖新华; 仝识非; 舒茂琴
Original assignee: First Affiliated Hospital of TMMU
Current assignee: Third Military Medical University TMMU; First Affiliated Hospital of TMMU
Priority date: 2012-08-29
Filing date: 2012-08-29
Publication date: 2015-03-18
Anticipated expiration: 2032-08-29
Also published as: CN102885648A

Abstract

The invention discloses a sympathetic nerve denervation ablation catheter system inside arteria renalis. The system comprises an ablation catheter, a guide catheter, a control handle, an ablation generator and a guide catheter control handle which can be arranged optionally. The ablation catheter comprises a catheter section and an ablation section from the near end to the far end in sequence, wherein the front end of the catheter body further comprises a controllable bending section and is connected with the control handle by the catheter body; and the ablation section comprises at least two independent structures, wherein an ablation head is arranged on at least one independent structure. With the adoption of the sympathetic nerve denervation ablation catheter system, multi-point ablation can be simultaneously achieved, so that the ablation effect is monitored during an operation in real time and mechanical stability is better.

Description

Kidney goes sympathetic nerve ablation catheter system

Technical field

The present invention relates to a kind of medical apparatus and instruments, specifically a kind of be used for Hypertension, entered the ablation catheter system blocking sympathetic renal nerve in renal artery by the mode got involved.

Background technology

Hypertension is common clinical, frequently-occurring disease, calculates according to up-to-date data, and Chinese hyperpietic group more than 200,000,000, and increases year by year in number of the infected, and age of onset shifts to an earlier date trend gradually.The important organ complication such as the heart that hypertension causes, brain, kidney, have very high fatality rate and disability rate, human health in serious harm.About there are 3000 ~ 4,000 ten thousand obstinate hypertension in China, and future is along with the increase of aged tendency of population and obesity, diabetes patient, and the patient populations of intractable hypertension will increase further, brings great burden to society, family, individual.Current without good intractable hypertension Therapeutic Method, open up new non-drug therapy means, make up the deficiency of current medical therapy thus simple, safety, effectively to control blood pressure very urgent.

Large quantity research confirms, the sympathetic nervous system of excessive activation and hypertensive formation are closely related with progress, wherein, sympathetic renal nerve system particularly near kidney Sympathetic Nerve and the nervus centripetalis of renal artery wall, is considered to the key factor of hypertension initiating and maintenance.For this mechanism, foreign scholar proposes by this new hypertension therapeutic strategy of catheter ablation renal artery sympathetic nerve treatment intractable hypertension.

2009, first Krum etc. produce Symplicity ablation catheter with Ardian company and go sympathetic nerve radio-frequency ablation procedure to 45 routine obstinate hypertension enforcement kidneys in catheter ablation sympathetic renal nerve treatment intractable hypertension research (Symplicity HTN-1), confirm simple, the safety of this new technique, antihypertensive effect occurs early, and can keep for a long time.Reaching in the tracing study of 2 years, do not finding that the blood pressure declined increases again, and kidney merit keeps stable.External multiple center is being carried out or is being completed the clinical research that percutaneous catheter kidney goes sympathetic nerve to treat and reaching ten remainders, completed or ongoing clinical test results encouraging, this technology is expected to become the revolutionary breakthrough in hypertension therapeutic field.

Technique application at home is still in the starting exploratory stage, and this product does not also enter domestic market, Fuwai Hospital on February 12nd, 2012 at home through giving special approval to Symplicity ablation catheter on probation operation to 4 routine obstinate hypertension successful implementations.Domestic You Jijia hospital implemented numerical example kidney in 2011 with heart radio frequency ablation catheter and goes sympathetic nerve to treat, and curative effect has not yet to see bibliographical information.

US 2011/0264075 A1 discloses and a kind of removes orthosympathetic radio frequency ablation catheter for kidney, although this kind of conduit producing of Ardian company clinical abroad in have certain application, also exist significantly not enough.First this kind of conduit only can carry out single point ablation, and because kidney goes orthosympathetic radiofrequency ablation therapy to be generally within one week, carry out 6-8 the spiral type put around renal artery to melt, therefore this kind of conduit of Ardian company needs to melt 6-8 time, and operating time is long.Ablation catheter for Ardian company can not carry out the problem that multiple spot melts, US 2012/0116392 A1, US 2012/0029510 A1, CN 201110117776.8, CN201110327772.2 by arranging radio-frequency ablation electrode respectively thus arrive the object that melts of multiple spot simultaneously on many strip electrodes bar, CN 102198015A then realizes multiple spot melt simultaneously by installing multiple radio-frequency electrode according to precalculated position on a spiral electrode stem, melt although above-mentioned design achieves multiple spot in renal artery to a certain extent simultaneously, but because radio-frequency ablation electrode and blood vessel wall are fitted tight not, make radio-frequency ablation electrode easily movement when melting, and cause ablation range excessive, unnecessary damage is caused to patient, closely attach blood vessel wall to make multiple radio-frequency ablation electrode simultaneously, US 2012/0101413A1 have employed the scheme arranging dilating sacculus in the electrode stem revolving shape, radio-frequency ablation electrode and blood vessel wall can be made closely to attach by being filled with liquid in sacculus, but renal hemodynamic can be blocked during balloon expandable, easily cause renal ischaemia if the time of melting is longer, and cause unnecessary complication, in order to avoid renal hemodynamic is blocked US 2012/0029512 A1, sacculus has been replaced to tinsel tennis, although solve the problem that renal hemodynamic is blocked, sacculus that operation is far from is convenient, the renal artery of this stranger walks row variation comparatively greatly, and the design of these multiple radio-frequency ablation electrodes above-mentioned is difficult to apply when renal artery traveling is morphed, because which limit the crowd that kidney goes sympathetic nerve to treat, and the design of above-mentioned multiple radio-frequency ablation electrode is due to only for radio-frequency (RF) ablation, is therefore difficult to same design to promote be used for laser ablation, microwave ablation etc.Secondly the injection frequency electrode catheter of Ardian company and the guiding of above-mentioned multiple frequency ablation electrode catheter control not accurate enough, make applicable crowd less than normal, therefore can not meet clinical requirement very well.Again, the injection frequency electrode catheter of Ardian company and the conduit of above-mentioned multiple radio-frequency ablation electrode are all difficult to carry out Real-Time Monitoring to the effect melted, and be therefore difficult to carry out examination of curative effect in art, patient's second operation risk is increased.Ablation catheter in the past mainly adopts line traffic control structure control, but line traffic control structure is not easy to operate, and structure is also more complicated, and the invention provides a kind of catheter control systems, structure is easier.

Summary of the invention

The object of this invention is to provide one can realize simultaneously multiple spot melt, can on-line real time monitoring melts barrier effect, the better kidney of mechanical stability goes sympathetic nerve ablation catheter system.

To achieve these goals and adopt technical scheme be such; namely a kind of kidney goes sympathetic nerve ablation catheter system; comprise ablation catheter, guiding catheter, joystick and melt generating means, described ablation catheter comprises catheter body section and the section of melting from lower to upper successively; Wherein:

Described catheter body section is connected with joystick;

The described section of melting is provided with absolute construction, and absolute construction is at least two, and the near-end of described absolute construction is connected, described in the section of melting have at least an absolute construction is provided with and melt head; The described head that melts is connected with the energy exchange joint on joystick by wire, conduit, microwave antenna or optical fiber, described energy exchange joint by wire, conduit, microwave antenna or optical fiber with melt generating means and be connected;

Described guiding catheter is attached on guiding catheter head end by tractive or propelling movement one end, and the guide wire that the other end is controlled by handle controls bending; Or described guiding catheter generation compliance is bending or prefabricated deformation;

Further, the far-end of described catheter body section is the controllable bending tune that is connected of the section of comprising and melt near-end also, and described controllable bending tune generation compliance is bending or/and arrange prefabricated deformation; Also comprise independent setting or not only erect the guiding catheter control handle put.

Further, described ablation catheter is or/and guiding catheter is or/and guiding catheter control handle is or/and joystick is also provided with sensor.

Following three kinds of structures are comprised: the far-end of two absolute construction connects as one and forms and melts paragraph header end between two absolute construction, or two absolute construction are separated from each other independently of one another, or the mid portion of two absolute construction links together, and far-end is separated from each other again.

When guiding catheter provides fulcrum for ablation catheter deformation, the head of guiding catheter arranges the inclined hole that communicates with blood vessel or/and side channel.

When the far-end of absolute construction connect as one and form melt paragraph header end time, guiding catheter head end arranges throat structure or plug, the head side wall of guiding catheter is arranged side channel; When absolute construction is separated from each other independently of one another, the head end of guiding catheter or head side wall arrange inclined hole.

When the mid portion of absolute construction links together, when far-end is separated from each other again, the head end of guiding catheter or head side wall arrange the inclined hole communicated with blood vessel, after inclined hole guiding catheter sidewall on side channel is set again.

When guiding catheter does not provide fulcrum for ablation catheter deformation, absolute construction arranges prefabricated deformation.

Also comprise controllable bending tune and prefabricated deformation is set.

Describedly melt that head is selected from radio-frequency ablation electrode head, resistance heated melts head, liquid cooling perfusion radio-frequency ablation electrode head, cryoablation head, supersonic melting probe, focused ultrasound ablation probe, laser ablation head, laser focusing melt head, optical dynamic therapy melts head or microwave ablation head; Wherein:

Described radio-frequency ablation electrode head comprises radio-frequency ablation electrode;

Described resistance heated melts head and comprises resistance heated ablating electrode;

Described liquid cooling perfusion radio-frequency ablation electrode head comprises radio-frequency ablation electrode, the surface of radio-frequency ablation electrode or near be provided with aperture, described aperture is connected with the conduit in separate component or separate chamber, pouring liquid fittings on described conduit or separate chamber and joystick, injects cooling liquid by pouring liquid joint;

Described cryoablation head comprises the coolant conducting surface be positioned on separate component, coolant chamber, the J-T nozzle being positioned at chamber coolant inlet side and refrigerant recovering conduit, and around described coolant conducting surface, tube wall contains adiabator; By input pipe, liquid or gas are transported to the coolant chamber be arranged on absolute construction by J-T nozzle;

Described laser ablation head or optical dynamic therapy melt head and include optical fiber, are positioned at aperture near optical fiber head, also comprise the cavity be communicated with aperture; Described laser focusing melts the lens spline structure arranged before head also comprises the head being positioned at optical fiber;

Described microwave ablation head comprises the microwave ablation contact be arranged on absolute construction, and described microwave ablation contact is connected with microwave antenna; The surrounding of described microwave ablation contact arranges insulating barrier, is also provided with coolant and derives aperture around microwave ablation contact.

The surrounding of described supersonic melting probe or focused ultrasound ablation probe arranges the conduit for carrying cooling liquid.

Or/and controllable bending tune is also provided with detection detecting electrode on described absolute construction; Or/and described in melt head be used for provide or/and receive electric pulse, barrier effect is melted in order to detect, on the absolute construction melt on head, melting around head or controllable bending tune can arrange detection detecting electrode, detecting electrode itself can with the ability providing and accept electric pulse.For the situation only having a detecting electrode, preferably detecting electrode is placed on the absolute construction melting on head or melt around head, after having melted, detecting electrode is placed in ablation points by kidney side, provide suitable electric pulse, if this electric pulse still can cause elevation of the blood pressure, then explanation is melted and is not blocked sympathetic renal nerve completely.For the situation of multiple detecting electrode, preferably keep at a certain distance away multiple detecting electrode setting, now melt except the detection method of barrier effect except adopting when only having a detecting electrode, at least two detecting electrodes can also be allowed to form the detecting electrode pair accepting and provide electric pulse, by the detecting electrode of at least two detecting electrodes compositions being opposite to before melting beginning and after having melted the both sides, front and back of ablation lesions, by before comparing ablation and the change that receives between electric impulse signal of postoperative detecting electrode also can judge ablation effect, if this signal does not change, illustrate that the sympathetic renal nerve of renal periarterial still may extend across ablation lesions place conduct electrical impulses, namely melt and do not block sympathetic renal nerve completely.Whether successfully above-mentioned two kinds of methods all can go sympathetic nerve art method as detection kidney, and these detection methods contribute to judging ablation effect in time in art, avoid second operation.In addition the melting head itself and also can double as into providing or/and receive the detecting electrode of electric impulse signal of some type, such as radio-frequency (RF) ablation detecting electrode head, liquid cooling perfusion radio frequency detecting electrode are first-class.Certain technical staff also can not arrange detecting electrode according to the function of ablation catheter.When arranging multiple detecting electrode, absolute construction before and after head can be respectively provided to a few detecting electrode melting, or at least one detecting electrode can be arranged on melt on head, melt around head absolute construction on and other detecting electrode is arranged on the place that controllable bending tune contacts with renal artery, or will head be melted as the granting of electric impulse signal or receive detecting electrode and be arranged on by detecting electrode on the absolute construction that melts around head or place that controllable bending tune contacts with renal artery.The shape of detecting electrode can be various, such as, can be that ring-type holds absolute construction, also can be semicircular, only hold the part of absolute construction and contacts blood, the little point-like of all right projection; In any case but the shape of detecting electrode should contribute to itself and contacts blood.The signal of reception passes on joystick preferably by the wire in ablation catheter by detecting electrode, and preferred finally passing to melts generating means.

The afterbody sidewall of described guiding catheter is also provided with the perforate carrying out Ink vessel transfusing injection or injection Intravascular contrast agents for connecting syringe or priming device, or by guiding catheter distal opening with syringe or/and priming device is connected carry out Ink vessel transfusing injection or/and inject Intravascular contrast agents; Or/and described guiding catheter end arranges jointing, jointing is connected with syringe, priming device, ablation catheter or joystick.

Described ablation catheter or/and by selecting the material of different hardness when guiding catheter manufactures, or passes through optionally to reduce or/and increase the internal structure of catheter segment or/and the structure of tube wall.

Described ablation catheter or/and reference mark on guiding catheter, to indicate ablation catheter or/and the degree of depth of guiding catheter intravasation and length, the width of indirect inspection organization of human body under ultrasonic or X ray image equipment; Ablation catheter is or/and guiding catheter is arranged different developing marks for distinguishing ablation catheter or/and guiding catheter under ultrasonic or X ray image equipment; Or/and each absolute construction is arranged different developing marks for distinguishing different absolute construction under ultrasonic or X ray image equipment; Ablation catheter is or/and guiding catheter is also arranged labelling for distinguishing different axial-rotation states under ultrasonic or X ray image equipment.

The end of ablation catheter is or/and guiding catheter and joystick upper end are fixed, and ablation catheter is connected with the connecting rod on annular control knob; The lower end of joystick or downside have energy exchange joint, collect at described energy exchange joint from melting the wire of head, conduit, microwave antenna or the optical fiber center cavity through joystick.

Ablation catheter is fixed by catheter body section and joystick upper end, and the lower end of joystick or downside have energy exchange joint, collects through joystick from melting the wire of head, conduit, microwave antenna or optical fiber at described energy exchange joint.

Described joystick is provided with the control knob for controlling guiding catheter deformation or console panel, described control knob or console panel are connected with guide wire, moving up and down by control knob, or realize the control to controllable bending tune by the multiple-directional rotating of console panel; Or/and annular control knob, described annular control knob is connected with traction fiber by connecting rod, and described connecting rod is arranged in the gathering sill of joystick, by moving up and down annular control knob, realizes the control to absolute construction; Also comprise the buffer structure that can prevent excessive tractive.

Described guiding catheter control handle is provided with the control knob for controlling guiding catheter deformation or console panel, described control knob or console panel are connected with guide wire, moving up and down by control knob, or realize the control to guiding catheter by the multiple-directional rotating of console panel; Described guiding catheter control handle and joystick comprise can take off groove tooth slide construction, can take off groove tooth slide construction by draw-in groove, cone column recesses, snap ring, hole clipping, hook formation and cone cylinder can be pressed to give prominence to tenon and form, undertaken break by groove tooth slide construction can be taken off and combine.

The described generating means that melts is provided with the joint of energy output and the joint of sensor signal input, is also provided with and external power supply phase ground joint simultaneously; Described melt generating means contain by carry out touch screen control controling parameters and partly or entirely information can show the button of display thereon and regulating parameter.

The present invention melts head owing to have employed at least two absolute construction and every bar absolute construction all can being arranged, therefore can realize multiple spot to melt simultaneously, shorten the time of melting, and then decrease operating time, reduce the misery of patient, in addition because the head that melts on many absolute construction when melting is incited somebody to action simultaneously and vessel wall contact, can prevent from melting head to slide, melt when making to melt add first watch stable, prevent when melting because melting the unnecessary damage of the unstable normal structure caused of head, decrease the complication melting generation, make ablation procedure safer.In addition, guiding catheter has corresponding line traffic control structure to control its deformation, therefore conduit has handling preferably, the renal artery of different traveling can be adapted to, and ablation catheter additional cover guiding catheter comes auxiliary ablation catheter location, whole like this ablation catheter system will be more accurate in endovascular location, prevent unnecessary damage, whole ablation system also can be made to be applied to more crowd simultaneously.In addition in this design, ablation catheter avoids complicated line traffic control structure, makes its structure more easy.Moreover, conveniently Real-Time Monitoring ablation effect in operation, ablation catheter is also provided with detecting electrode and detects ablation effect in time to facilitate, avoid second operation risk.Finally, the design of this ablation catheter can adapt to multiplely melt head, such as radio-frequency (RF) ablation, cryoablation, microwave ablation etc., is easy to promote.

Accompanying drawing explanation

Fig. 1 is the schematic diagram of the major part of an embodiment of the invention.

Fig. 2 is the schematic diagram of the connected mode in the section of melting of amplifying between two absolute construction.

Fig. 3 is the schematic diagram after there is deformation between two absolute construction under different connected modes in the section of melting of amplifying.

Fig. 4 is the schematic diagram melting head set-up mode different on absolute construction.

Fig. 5 melts schematic diagram when head is radio-frequency ablation electrode head.

Fig. 6 melts schematic diagram when head is liquid cooling perfusion radio frequency electrical cartridge.

Fig. 7 melts cross sectional representation when head is liquid cooling perfusion radio frequency electrical cartridge.

Fig. 8 melts vertical section schematic diagram when head is arranged on absolute construction head.

Fig. 9 melts head to be microwave ablation head and this melts vertical section schematic diagram when head is positioned at absolute construction head.

Figure 10 melts head to be cryoablation head and this melts vertical section schematic diagram when head is positioned at absolute construction head.

Figure 11 melts head to be cryoablation head and this melts schematic diagram when head is positioned at absolute construction mid portion.

Figure 12, Figure 16 melt head to be laser ablation head and this melts vertical section schematic diagram when head is positioned at absolute construction head.

Figure 13 melts head to be laser ablation head and this melts schematic top plan view when head is positioned at absolute construction head and diagrammatic cross-sectional view.

Figure 14 melts head to be that laser focusing melts head and this melts sketch of longitudinal section when head is positioned at absolute construction head.

Figure 15 melts schematic diagram when head is laser ablation head and arranges diagnostic ultrasonic probe.

Figure 17 be melt head be laser ablation head and this melts head rest nearly absolute construction mid portion time vertical section schematic diagram.

Figure 18 be melt head be ultrasonic probe, focus supersonic or high intensity focused ultrasound probe and this probe is positioned at absolute construction head time schematic diagram.

Figure 19 dissimilar melts the vertical section schematic diagram of head on different absolute construction.

The sketch of the section of melting that Figure 20 is absolute construction when being two.

The sketch of the section of melting that Figure 21 is absolute construction when being three.

The sketch of the section of melting that Figure 22 is absolute construction when being four.

Figure 23 is the sketch of absolute construction when being three and being separated from each other under duty.

The cross-sectional profiles sketch that Figure 24 is absolute construction when being two to four.

Schematic diagram during Figure 25 to be controllable bending tune be C shape design under duty.

Figure 26, Figure 27, Figure 28, Figure 29 be for two absolute construction and guiding catheter can for the deformation of ablation catheter fulcrum is provided when, the schematic diagram of guiding catheter head.

Figure 30 is when being connected to for far-end two absolute construction melting paragraph header end, the schematic diagram under the schematic diagram of guiding catheter head and ablation catheter and guiding catheter duty

Figure 31, Figure 32 are the schematic diagrams being changed ablation catheter and the distribution of guiding catheter hardness by the mode of structural design.

Figure 33 is the schematic diagram of the hardness distribution realization design deformation being connected to the absolute construction melting paragraph header end by adjustment far-end.

Figure 34 is the schematic diagram being realized design deformation by the hardness distribution of adjustment controllable bending tune.

Figure 35 is the schematic diagram of the hardness distribution realization design deformation by adjusting the absolute construction be separated from each other.

Figure 36, Figure 37 realize the schematic diagram of design deformation by adjusting the link together hardness distribution of absolute construction that far-end is separated from each other again of middle somewhere.

Figure 38 is the project organization schematic diagram of marmem.

Figure 39 is the schematic diagram of guiding catheter afterbody primary structure.

Figure 40 is the line traffic control structure of guiding catheter and promotes that guiding catheter forms the schematic diagram of required deformation form by chicken ribs spline structure.

Figure 41, Figure 42, Figure 43 are when for line traffic control structure, the schematic diagram of the main structure of several dissimilar joystick.

Detailed description of the invention

Below in conjunction with the drawings and specific embodiments, set forth the present invention further.These embodiments are interpreted as only being not used in for illustration of the present invention limiting the scope of the invention.After the content of having read the present invention's record, technical staff can be used for various modifications the present invention or revise, and these equivalence changes and modification fall into the scope of the claims in the present invention equally.

Fig. 1 shows parts main in the specific embodiment of the present invention.As shown in Figure 1, this kind of kidney goes sympathetic nerve ablation system primarily of ablation catheter 1, guiding catheter 7, joystick 2 and melts generating means 3 and form, and according to circumstances arranges or does not arrange guiding catheter control handle 27.As shown in Figure 1, ablation catheter 1 far-end (head end) dissociates, near-end (tail end, end) is connected with joystick 2, ablation catheter 1 is distally at least made up of catheter body section 4 and the section of melting 6 successively near-end, wherein the near-end (tail end, end) of catheter body section 4 is connected with joystick 2, the far-end (head end) of the section of melting 6 dissociates, catheter body section front end also can comprise controllable bending tune 5, according to circumstances also can arrange other section between catheter body section 4 and the section of melting 6.Preferably, the outline of ablation catheter 1 each section of cross section preferably adopts circle or similar round, and it is preferably close or equal that ablation catheter 1 enters into endovascular each section of diameter.The ablation site that the length of ablation catheter 1 must make the section of melting 6 can arrive bilateral renal arteries smoothly to specify, be generally 50--120cm, and the maximum gauge of each section of whole ablation catheter 1 be preferably less than must through the minimum diameter of blood flow paths medium vessels, the diameter of ablation catheter 1 is generally 1.4--2.5mm.As shown in Figure 1, wherein guiding catheter 7 is preferably hollow tubular structure, and head and the tail two ends are equipped with opening, and guiding catheter 7 is enclosed within outside ablation catheter 1 can assist ablation catheter 1 to arrive the ablation locations of specifying.The ablation site that the length of guiding catheter 7 must make guiding catheter 7 can successfully guide ablation catheter 1 to arrive bilateral renal arteries to specify, be generally 50--120cm, and the maximum outside diameter of each section of whole guiding catheter 7 be preferably less than must through the minimum diameter of blood flow paths medium vessels, the diameter of guiding catheter 7 is generally 1.4--2.5mm.

Fig. 2 shows the main feature of the section of melting 6 in embodiments of the invention.As shown in Figure 2, the section of melting 6 is made up of at least two absolute construction 8; This absolute construction 8 can be cylinder shape, similar cylinder shape, semi-cylindrical, cone-shaped, similar cone-shaped, arc etc., the length of each absolute construction 8 and cross sectional dimensions can equally also can not wait, but preferably, the outline of the section of melting 6 cross section that surrounds of the outline of all absolute construction 8 cross sections is preferably close to the outline of controllable bending tune 5 cross section.As shown in Figure 2 A, the far-end (head end) of two absolute construction 8 is connected to and melts paragraph header end 17 (being also ablation catheter head end); As shown in Figure 2 B, two absolute construction 8 are separated from each other, independently of one another; As shown in Figure 2 C, the middle somewhere of two absolute construction 8 far-end that links together is separated from each other again, and wherein junction point 18 is the place that described two absolute construction 8 link together.The tail end of absolute construction 8 is connected in the controllable bending tune 5 of catheter body section 4 front end.

Fig. 3 show absolute construction 8 in embodiments of the invention under different two connected modes, there is deformation after situation.Wherein Fig. 3 A show far-end be connected to the absolute construction 8 melting paragraph header end 17 there is deformation after situation, now the mid portion of absolute construction 8 is by four loose protuberances, usually, with the centre of absolute construction 8 or the most obvious near middle protuberance.Fig. 3 B shows when absolute construction 8 is separated from each other and the situation after deformation occurs, now absolute construction 8 will mutually away from, usually, with the head end of absolute construction 8 and neighbouring position thereof mutually away from the most obvious.Fig. 3 C shows the middle somewhere of absolute construction 8 far-end that links together and the situation after deformation occurs when being separated from each other again, now incite somebody to action mutually from junction point 18 to the part of absolute construction 8 head end, usually, with absolute construction 8 head end and neighbouring position thereof mutually away from the most obvious, part from junction point 18 to absolute construction 8 tail end (end, far-end) is by four loose protuberances, usually, with the centre of the part between junction point 18 to absolute construction 8 tail end or the most obvious near middle protuberance.

Fig. 4 shows in embodiments of the invention and melts 9 set-up modes different on absolute construction 8.As shown in Figure 4 A, have at least an absolute construction 8 is provided with and melt 9; As shown in Fig. 4 B, Fig. 4 C, each absolute construction 8 can arrange not only one melt 9.Melt 9 to be mainly used in melting blocking-up to sympathetic renal nerve; Melting 9 should be the original paper playing ablation, therefore melt 9 and there is polytype, such as: radio-frequency ablation electrode head, liquid cooling perfusion radio-frequency ablation electrode head, cryoablation head, supersonic melting probe, focused ultrasound ablation probe, high intensity focused ultrasound ablation probe, laser ablation head, laser focusing melt head, optical dynamic therapy melts head, microwave ablation head, resistance heated melt first-class.On different absolute construction 8 melt 9 type can be identical or different, multiple on same absolute construction 8 melt 9 type also can be identical or different, such as: melting on an absolute construction 89 is cryoablation heads, and melting on another absolute construction 89 is radio-frequency ablation electrode heads, or melting of same absolute construction 8 front end 9 is that laser focusing melts head, then one melts 9 is microwave ablation heads, and this just makes to change ablation catheter 1 in varied situations just can complete multi-form melting.According to melting a difference for 9 types, melt 9 different with the connecting media of energy exchange joint 201 on joystick 2, such as: melt 9 for laser ablation head time, connecting media is generally optical fiber, and melt 9 for radio-frequency ablation electrode head time, connecting media is generally wire, melt 9 for cryoablation head time, connecting media is generally conduit.

Fig. 5 is connected to for the far-end of two absolute construction 8 to melt paragraph header end 17, shows and melts 9 main structures when being radio-frequency ablation electrode head.Fig. 5 A shows the main structure under vertical section, and radio-frequency ablation electrode head comprises radio-frequency ablation electrode 91, and preferably, radio-frequency ablation electrode 91 slightly protrudes from the surperficial 0.05--0.2mm of absolute construction 8, so that and vessel wall contact.As shown in Figure 5A, the radio-frequency wires 101 of traveling in absolute construction 8 will be connected with radio-frequency ablation electrode pole 91, and for radio-frequency ablation electrode 91 provides energy, wire junction point 191 is link positions of radio-frequency wires 101 and radio-frequency ablation electrode 91.As shown in Figure 5A, holding wire 102 with to be arranged on radio-frequency ablation electrode 91 or/and the sensor 192 of contiguous radio-frequency ablation electrode 91 is connected, for the signal that transmission sensor 192 (Fig. 5 B shows) sends; Sensor 192 can be dissimilar, such as: temperature sensor, impedance transducer, pressure transducer etc.; The sensor 192 of same type also can more than one (Fig. 5 be with a sensor 192 exemplarily) on absolute construction 8; The parameter monitoring of sensor 192 radio frequency ablating electrode 91 and human body, contributes to understanding real-time condition, adjusts therapeutic scheme in time.Fig. 5 B and Fig. 5 C shows the main structure of radio-frequency ablation electrode head 9 and surrounding absolute construction 8 thereof in a perspective fashion.As shown in Figure 5 B, radio-frequency ablation electrode 91 (figure bend represents part) only can hold the bent side of semicylinder and not hold the flat side 90 of semicylinder; As shown in Figure 5 C, the bent side that radio-frequency ablation electrode 91 (figure bend represents part) both can hold semicylinder also holds the flat side 90 of semicylinder; Certain radio-frequency ablation electrode 91 also can according to circumstances adjust the scope that it holds.Melt 9 for this design can be imitated when resistance heated melts.Fig. 5 is connected to for the far-end of two absolute construction 8 to melt the design that paragraph header end 17 carries out melting 9 and illustrate, therefore an illustrated in Figure 5 design melting 9 is equally applicable to other connected modes of absolute construction 8 and the situation of multiple absolute construction 8; In addition technical staff can also adjust melting 9 setting positions on absolute construction 8 as required; For the situation that absolute construction 8 shape is not semi-cylindrical situation and changes to some extent for the shape of the absolute construction 8 at radio-frequency ablation electrode 91 setting position place, design illustrated in Figure 5 also can be copied to design.

Fig. 6, Fig. 7 show and melt 9 main structures when being liquid cooling perfusion radio-frequency ablation electrode head, and wherein Fig. 7 is the cross sectional representation of liquid cooling perfusion radio-frequency ablation electrode head.As shown in Figure 6A, liquid cooling perfusion radio-frequency ablation electrode head comprises radio-frequency ablation electrode 91, preferably, there are some apertures 193 on the surface of radio-frequency ablation electrode 91, aperture 193 is connected with conduit 103, and the surface that the cooling liquid accessed from the pouring liquid joint 202 on joystick 2 is sprayed onto liquid radio-frequency ablation electrode 91 by aperture 193 lowers the temperature by conduit 103; As shown in Figure 6A, conduit 103 can be connected respectively with each aperture, also can adopt the design of Fig. 6 B, and conduit 103 is connected with the cavity 69 under aperture 193, is sent by liquid by cavity 69 from each aperture.As shown in Figure 6 C, the mode of cooling can also adopt the circulating fluid pipeline melted around 9, preferably conduit 103 is made helical form, liquid coolant is poured into from the porch shown in arrow ao1, flow out from arrow ao2.Liquid coolant generally uses cool brine.Above-mentioned two class cooling methods can conbined usage, and also can be used for rewarming, as long as adjustment infusion liquid temperature.Need to lower the temperature or the melting of other types of rewarming 9 also can adopt above-mentioned design simultaneously.Fig. 7 A shows radio-frequency ablation electrode 91 when only holding the bent side of semicylinder and do not hold flat side 90 of semicylinder, the main structure of liquid cooling perfusion radio-frequency ablation electrode head cross section; The upper semi-circle of Fig. 7 A shows radio-frequency wires 101, holding wire 102 and the situation of conduit 103 traveling in separate chamber 60, in absolute construction 8, namely allow the traveling in independently chamber of above-mentioned three structures, to prevent the interference of other structures; The lower half circle of Fig. 7 A shows radio-frequency wires 101, holding wire 102 and the situation of conduit 103 traveling in absolute construction 8, and now above-mentioned three structures will mix traveling with other structures.Fig. 7 B shows radio-frequency ablation electrode 91 when holding flat side 90 of the bent side of semicylinder and semicylinder, the main structure of liquid cooling perfusion radio-frequency ablation electrode head cross section; The upper semi-circle of Fig. 7 B shows radio-frequency wires 101, holding wire 102 and the situation of conduit 103 traveling in separate chamber 60; Fig. 7 B lower half circle display be radio-frequency wires 101, holding wire 102 and the situation of conduit 103 traveling in absolute construction 8, now above-mentioned three structures will mix traveling with other structures.Separate chamber 60 can be divided into multiple separate chamber for the different component of traveling, this kind with the mentality of designing of chamber traveling different component respectively also can be used for other types melt 9, other parts of ablation catheter 1 and guiding catheter 7.Shape for absolute construction 8 is not semi-cylindrical situation and situation about changing to some extent for the shape of absolute construction 8 at liquid cooling perfusion radio-frequency ablation electrode head 9 setting position place, also can copy Fig. 6, design illustrated in Figure 7 designs.

Fig. 8 be melt 9 for radio-frequency ablation electrode head be example, show the main structure melting 9 vertical sections when being arranged on two absolute construction 8 heads that far-end is separated from each other; Wherein, what Fig. 8 A showed is melts 9 the bent sides holding semicylinder and does not hold the situation of the flat side 90 of semicylinder, and what Fig. 8 B showed is melts the situation that 9 hold the bent side of semicylinder and the flat side 90 of semicylinder.The design of radio-frequency ablation electrode head illustrated in Figure 8 and the design of radio-frequency ablation electrode head illustrated in Figure 5 similar.As shown in Fig. 8 A, Fig. 8 B, the far-end of absolute construction 8 can mutually away from, similarly, the radio-frequency wires 101 of traveling in absolute construction 8 will be connected with radio-frequency ablation electrode 91, for radio-frequency ablation electrode head 9 provides energy, wire junction point 191 is positions that radio-frequency wires 101 is connected with radio-frequency ablation electrode 91.As shown in Fig. 8 A, Fig. 8 B, similarly, holding wire 102 with to be arranged on radio-frequency ablation electrode 91 or/and the sensor 192 of contiguous radio-frequency ablation electrode 91 is connected, for the signal of transmission sensor 192 transmission; Similarly, sensor 192 can be dissimilar, such as: temperature sensor, impedance transducer, pressure transducer etc.; The sensor 192 of same type also can more than one (Fig. 8 be with a sensor 192 exemplarily) on absolute construction 8; The parameter monitoring of sensor 192 radio frequency ablating electrode head 9 and human body, contributes to understanding real-time condition, adjusts therapeutic scheme in time.As shown in Figure 8 A, radio-frequency ablation electrode 91 only can hold the bent side of semicylinder and not hold the flat side 90 of semicylinder; As shown in Figure 8 B, the bent side that radio-frequency ablation electrode 91 both can hold semicylinder also holds the flat side 90 of semicylinder; Certain radio-frequency ablation electrode 91 also can according to circumstances adjust the scope that it holds absolute construction 8.Because the design shown in Fig. 8 is described for radio-frequency ablation electrode head to melt 9, therefore this design is equally applicable to melt the situation melting head that 9 are other types, what now need radio-frequency ablation electrode head to replace to other types melts head, and such as liquid cooling perfusion radio-frequency ablation electrode head, resistance heated melt first-class; Situation for multiple absolute construction 8, the shape for absolute construction 8 for semi-cylindrical situation and for melting a situation that the shape of the absolute construction 8 at 9 setting position places changes to some extent, also can not copy design illustrated in Figure 8 to design.

Fig. 9 shows the main structure melting 9 vertical sections when being microwave ablation head, and Fig. 9 is arranged on for microwave ablation head two absolute construction 8 heads that far-end is separated from each other to be described.As shown in Figure 9, microwave ablation head comprises microwave ablation contact 93, two absolute construction 8 far-ends are separated from each other, the microwave antenna 106 be connected with microwave ablation contact 93 is for transmitting microwave to microwave ablation contact 93, insulating barrier 87 (grid representation) is preferably set around microwave ablation contact 93, generally selects tetrafluoro insulator.As shown in Figure 9, sensor 192 contacts for parameters such as monitoring temperatures near microwave ablation contact 93 or with microwave ablation contact 93, and preferably to be passed back by the signal of sensor 192 by holding wire 102 and melt generating means 3.As shown in Figure 9, be preferably provided with multiple aperture 193 for spraying cooling liquid around microwave ablation contact 93, these apertures 193 are connected with conduit 103; Aperture 193 also can be opened on microwave ablation contact 93, and now conduit 103 need penetrate microwave ablation contact 93.Situation for multiple absolute construction 8, other two connected modes for absolute construction 8, situation microwave ablation contact 93 being arranged on to other positions of absolute construction 8 and situation about changing to some extent for the shape of the absolute construction 8 at microwave ablation contact 93 setting position place, can imitate design illustrated in Figure 9 and design.

Figure 10 shows and melts 9 and be cryoablation head and this melts the main structure in vertical section when head is positioned at the head of two absolute construction 8 that far-end is separated from each other.As shown in Figure 10, preferably, cryogenic liquid or gases at high pressure etc. are transported to the coolant chamber 61 being arranged in absolute construction 8 head by input pipe 194; The size of coolant chamber 61 can be different, and the coolant chamber 61 that the coolant chamber 61 that Figure 10 B and Figure 10 C illustrates just is illustrated compared with Figure 10 A is little.As shown in Figure 10 A, cryogenic liquid or gases at high pressure arrive after coolant chamber 61 through input pipe 194, preferable through helical fin 192, spray finally by J-T nozzle 190, cryogenic liquid after ejection or gases at high pressure reclaim through reclaiming conduit 64, reclaim conduit 64 and eventually pass through operating grip part 2, be connected with responsible recovery, discharge, the equipment that processes this cryogenic liquid or gases at high pressure.As shown in Figure 10 A, helical fin 192, due in coolant chamber 61, serves the effect of pre-cooling cryogenic liquid or gases at high pressure; The design can certainly illustrated as Figure 10 B, Figure 10 C, helical fin 192 is not set, input pipe 194 is directly connected with J-T nozzle 190.The good material of the preferred conduction of heat of cryoablation head 9 is made, preferable alloy.As shown in Figure 10, the tube wall 86 be connected with coolant conducting surface 94 preferably adiabator is made, or adopts the hollow structure of contain air.As shown in Figure 10, sensor 192 is positioned at or/and coolant chamber 61 on coolant conducting surface 94, and primary responsibility is monitored temperature, pressure and other parameters, the signal return that sensor 192 will be gathered by wire 102.As shown in Figure 10 A, Figure 10 B, cryoablation head 9 can hold the bent side of semicylinder and the flat side 90 of semicylinder; As illustrated in figure 10 c, coolant conducting surface 94 also only can hold the bent side of semicylinder and not hold the flat side 90 of semicylinder.Figure 11 shows and melts 9 and be cryoablation head and this melts head and is positioned at construction features when far-end is connected to two absolute construction 8 mid portions melting paragraph header end 17, wherein Figure 11 A is vertical section schematic diagram, and Figure 11 B and Figure 11 C is the schematic diagram that the cross section at cryoablation head place amplifies; Design illustrated in Figure 11 is based on design illustrated in Figure 10, therefore for design illustrated in Figure 11 and the similar place of design illustrated in Figure 10, just no longer repeats here.Conveniently other need the structure of independent traveling by cryoablation head 9, as shown in Figure 11 B, Figure 11 C, can arrange separate chamber 60 at coolant chamber 61 by the center line side of the section of melting 6.Helical fin 192 illustrated in Figure 10 can optionally for design illustrated in Figure 11.As shown in Figure 11 B, coolant conducting surface 94 also only can hold the bent side of semicylinder and not hold the flat side 90 of semicylinder.Cryoablation head 9 can hold the bent side of semicylinder and the flat side 90 of semicylinder as shown in Figure 11 C.Situation for multiple absolute construction 8, other two connected modes for absolute construction 8, situation cryoablation head being arranged on to other positions of absolute construction 8 and situation about changing to some extent for the shape of the absolute construction 8 at cryoablation head setting position place, can copy Figure 10, design illustrated in Figure 11 designs.

Figure 12, Figure 16 show and melt 9 and be laser ablation head 96 and this melts the main structure in vertical section when head is positioned at two absolute construction 8 heads that far-end is separated from each other; Figure 13 then shows the main structure of overlooking of design illustrated in Figure 12 and cross section, and wherein Figure 13 A is the schematic top plan view of absolute construction 8 head, and Figure 13 B, Figure 13 C, Figure 13 D are the diagrammatic cross-sectional view of absolute construction 8; Figure 17 shows and melts 9 and be laser ablation head 96 and this melts the main structure that head is positioned at vertical section when far-end is connected to the interlude of two absolute construction 8 melting paragraph header end 17; Figure 15 shows and melts 9 main structures when being laser ablation head 96 and being provided with diagnostic ultrasonic probe, this laser ablation head 96 is positioned at the head of two absolute construction 8 that far-end is separated from each other, this ultrasonic probe is arranged on laser ablation head 96 place, wherein Figure 15 A is the vertical section schematic diagram of absolute construction 8 head, and Figure 15 B is the schematic top plan view of absolute construction 8 head.As shown in Figure 12, Figure 13 A, Figure 16, Figure 17, laser ablation head 96 includes the cavity 69 after the head of optical fiber 95, aperture 193 and aperture 193; Optical fiber 95 can be and singlely also can be many, and when optical fiber 95 is many, the form that its arrangement mode can melt as required is selected, as " one " font, annular etc.As shown in Figure 12, Figure 15 A, Figure 16, Figure 17, laser ablation head 96 preferably slightly caves in compared with the outer surface of absolute construction 8, to carry out lowering the temperature and prevent adhesion when melting, general cup depth is 0.05--0.3mm.As shown in Figure 12, Figure 15 A, Figure 16, Figure 17, laser ablation head 96 is preferably by liquid cooling cooling-down, and the conveying cooling conduit 103 of liquid is connected with the cavity 69 under aperture 193, is sprayed by cavity 69 for the liquid of lowering the temperature from aperture 193; Certain conduit 103 also can directly be connected with each aperture 103 (shown in similar Fig. 6 A).As shown in Figure 13 A and Figure 15 B, the opening of the uniform wound fiber 95 of aperture 193.As shown in Figure 12, Figure 15 A, Figure 16, Figure 17, be provided with sensor 192 at the head of optical fiber 95, for parameters such as monitoring temperatures, and by holding wire 102 by the signal return of sensor 192.As shown in Figure 12, Figure 13 A, Figure 15, Figure 16, Figure 17, the surrounding of laser ablation head 96 can be provided with the granting for electric pulse or/and the detecting electrode 19 that receives, to judge that sympathetic renal nerve melts barrier effect, detecting electrode 19 slightly protrudes from absolute construction 8 outer surface, be convenient to fully contact with blood vessel wall, wire 119 is connected with detecting electrode 19, for receiving or/and provide electric impulse signal; Detecting electrode 19 around laser ablation head 96 can be more than one, such as shown in figure 17, can have the detecting electrode 19 of two around laser ablation head 96, during work, one for providing electric pulse, one for receiving electric pulse; Surrounding for laser ablation head 96 only has the situation of a detecting electrode 19, should arrange another detecting electrode 19 in other parts of ablation catheter, and make one for providing electric pulse, one for receiving electric pulse.As shown in Figure 12, Figure 13 B, Figure 13 C, Figure 13 D, Figure 15, the form of the head outline of absolute construction 8 can be different from shown in Fig. 8, Fig. 9, Figure 10, Figure 16 etc., for two absolute construction 8, in Figure 12, Figure 13 B, Figure 13 C, Figure 13 D, Figure 15, the semi-cylindrical flat side of the head of absolute construction 8 will toward the outside and bent side will towards interior, such design is so that the absolute construction around laser ablation head 96 8 and blood vessel wall attach more closely, and stabilized lasers melts 96; Wherein Figure 13 B, Figure 13 C, Figure 13 D illustrate the change of absolute construction 8 cross section outline, the cross section outline of what Figure 13 B represented is absolute construction 8 head, the cross section outline of what Figure 13 D represented is absolute construction 8 mid portion and afterbody, Figure 13 C then illustrates the change procedure of cross section outline to the cross section outline of absolute construction 8 mid portion of absolute construction 8 head.As shown in fig. 15, diagnostic ultrasonic probe 199 can be set at the head end of absolute construction 8; As shown in fig. 15b, dotted line represents ultrasonic probe 199, and it preferably adopts annular design around laser ablation head 96.Situation for multiple absolute construction 8, other two connected modes for absolute construction 8, situation laser ablation head 96 being arranged on to other positions of absolute construction 8 and situation about changing to some extent for the shape of the absolute construction 8 at laser ablation head 96 setting position place, can copy Figure 12, Figure 13, Figure 15, Figure 16, design illustrated in Figure 17 designs.

Figure 14 melts 9 for laser focusing to melt 97 and this melts the brief configuration feature in vertical section when head is positioned at the head of two absolute construction 8 that far-end is separated from each other.As shown in figure 14, be preferably multifiber 95, certainly also can be single, but now optical fiber 95 diameter preferably more time thick.Lens spline structure 195 is preferably provided with, for connecting laser before the opening on absolute construction 8 of multifiber 95; Can fill liquid in lens spline structure 195, and have conduit to be connected with this packing fluid, by change packing fluid density and change fill liquid number so that the index of refraction of changes lens spline structure 195 and surface curvature play the effect of the focus adjusting laser; In addition can by changing the wavelength shift focus of laser.Laser focusing melts 97 when being arranged on absolute construction 8 mid portion imitates this design.Situation for multiple absolute construction 8, other two connected modes for absolute construction 8,97 are melted for laser focusing be arranged on the situation of other positions of absolute construction 8 and a situation that the shape of the absolute construction 8 at 97 setting position places changes to some extent is melted for laser focusing, design illustrated in Figure 14 can be copied to design.This infrared optical fiber 95 also can transmit the light beam for optical dynamic therapy, and remainder structure can copy that to melt 9 be that laser ablation head and laser focusing design when to melt designs.

Figure 18 show melt 9 for supersonic melting probe 98 or focused ultrasound ablation probe 99 and this ablation probe is positioned at two absolute construction 8 heads that far-end is separated from each other time construction features; Wherein Figure 18 A is the profilograph of absolute construction 8 head, and Figure 18 B is the top view of absolute construction 8 head.As shown in Figure 18 A, melting 9 is supersonic melting probe 98 or focused ultrasound ablation probe 99, and supersonic melting probe 98 or focused ultrasound ablation probe 99 preferably slightly protrude from the outer surfaces of absolute construction 8, so that it fully contacts with blood vessel wall.As shown in Figure 18 A, ultrasonic wire 104 and supersonic melting pop one's head in 98 or focused ultrasound ablation pop one's head in and 99 to be connected, for 99 transmission of power of popping one's head in supersonic melting probe 98 or focused ultrasound ablation.As shown in Figure 18 A, Figure 18 B, the surrounding of supersonic melting probe 98 or focused ultrasound ablation probe 99 is provided with detecting electrode 19, detecting electrode 19 slightly protrudes from absolute construction 8 outer surface, for providing or/and receive electric impulse signal, to judge that sympathetic renal nerve melts barrier effect; During work, one for providing electric pulse, one for receiving electric pulse; Quantity according to practical situation detecting electrode 19 can increase and decrease; As shown in Figure 18 A, wire 119 is connected with detecting electrode 19, for receiving or/and provide electric impulse signal.As shown in Figure 18 A, Figure 18 B, conduit 103 be opened on melt 9 surrounding for carrying cooling liquid, aperture 193 is the opening of conduit 103.Situation for multiple absolute construction 8, other two connected modes for absolute construction 8, head is melted for ultrasonic class be arranged on the situation of other positions of absolute construction 8 and a situation that the shape of the absolute construction at setting position place 8 changes to some extent is melted for ultrasonic class, design illustrated in Figure 18 can be copied to design.

Two absolute construction 8 that Figure 19 is separated from each other for far-end, list dissimilar melt 9 on different absolute construction 8 time vertical section main structure.As shown in figure 19, being positioned at and absolute construction 8a melts a 9a is supersonic melting probe 98 or focused ultrasound ablation probe 99, its design is identical with design illustrated in Figure 18, and the 9b that melts be positioned on absolute construction 8b is laser ablation head 96, its design is identical with design illustrated in Figure 12.Figure 19 just lists and a kind ofly dissimilar melts 9 combinations on different absolute construction 8, for other melt 9 combination can with reference to corresponding melt 9 design; In addition, situation for multiple absolute construction 8, other two connected modes for absolute construction 8, for melt 9 be arranged on other positions of absolute construction 8 situation and for melting a situation that the shape of the absolute construction 8 at 9 setting position places changes to some extent, design 9 illustrated in Figure 19 can be copied to melt 9 combine dissimilar.

As the case may be, technical staff can be merged for a dissimilar design melting 9, improve and cross-reference above-mentioned these, these equivalence changes and modify and fall into the scope of the claims in the present invention equally.

The main structure of the section of melting 6 that Figure 20, Figure 21, Figure 22 have shown absolute construction 8 respectively when being two to four.Figure 23 lists situation when absolute construction 8 is three and is separated from each other under duty.The cross-sectional profiles that Figure 24 has shown absolute construction 8 when being two to four.As shown in figure 20, when absolute construction 8 is two, best each absolute construction 8 is provided with one and melts 9.

As shown in FIG. 20 A, the far-end of two absolute construction 8 is connected to and melts paragraph header end 17, two absolute construction 8 preferably wait large, each absolute construction 8 length is preferably 13--30mm, the deformation of two absolute construction 8 is swelled relatively by making the mid portion of two absolute construction 8, form similar fusiform structure, protuberance is the most local to be generally positioned at the centre of absolute construction 8 or first will to contact blood vessel wall near middle position, now melts 9 and is preferably arranged at each absolute construction 8 and swells the most local; Each absolute construction 8 swells the most obvious place can different (shown in similar Figure 33 B); The most obvious partial-length of median rise of each absolute construction 8 can different (shown in similar Figure 33 D), and now melting 9 can on same cross section or not on same cross section at the setting position of each absolute construction 8.As shown in fig. 20b, two absolute construction 8 are separated from each other, the length of two absolute construction 8 is preferably equal, each absolute construction 8 length is preferably 10--20mm, the deformation of two absolute construction 8 will make two absolute construction 8 mutually away from, the head end of general absolute construction 8 and neighbouring position thereof, mutually away from the most obviously and first will contact blood vessel wall, are now melted 9 and are preferably disposed on the head end of each absolute construction 8 and neighbouring position thereof; If wish, ablation points is on the varying cross-section of blood vessel, the length of two absolute construction 8 unequal (shown in similar Figure 35 B) can be made, or the length of two absolute construction 8 is equal, but melt 9 at the setting position of each absolute construction 8 head different (shown in similar Figure 35 C).As shown in Figure 20 C, the middle somewhere of two absolute construction 8 far-end that links together is separated from each other again, the length of two absolute construction 8 is preferably equal, the length of each absolute construction 8 is preferably 20--40mm, and junction point 18 is preferably selected to account for the place of whole absolute construction 8 length 30--50% at absolute construction 8 far-end to the part of junction point 18, as shown in Figure 20 C, the part making junction point 18 to absolute construction 8 tail end is swelled by the deformation of two absolute construction 8 relatively, generally relatively swell the most obvious with in the middle of this part or close middle position, and junction point 18 to absolute construction 8 head end part mutually away from, generally with the head end of absolute construction 8 and neighbouring position thereof mutually away from the most obvious, four positions now will be had preferentially to contact blood vessel wall, i.e. head end and neighbouring position thereof the place the most obvious with protuberance of two absolute construction 8, preferably be arranged at the head end of two absolute construction 8 and neighbouring position thereof by melting 9, and detecting electrode 19 can be arranged on median rise the most significantly place, if wish, ablation points is on the varying cross-section of blood vessel, the partial-length in two absolute construction 8 between junction point 18 to absolute construction 8 head end unequal (shown in similar Figure 37 B) can be made, or the length of two absolute construction 8 is equal, the length of the absolute construction 8 between junction point 18 to absolute construction 8 tail end is also equal, but melts 9 at the setting position of each absolute construction 8 head not identical (shown in similar Figure 37 C).

As shown in figure 21, when absolute construction 8 is three, best each absolute construction 8 is provided with one and melts 9.As illustrated in fig. 21, the far-end of three absolute construction 8 is connected to and melts paragraph header end 17, three absolute construction 8 preferably wait large, the length of each absolute construction 8 is preferably 13--30mm, the deformation of three absolute construction 8 will make the loose protuberance of mid portion four of three absolute construction 8, form similar fusiform structure, protuberance is the most local to be generally positioned at the centre of absolute construction 8 or first will to contact blood vessel wall near middle position, the most obvious place of mid portion protuberance of each absolute construction 8 is preferably different, now melting 9, to be preferably disposed on protuberance the most local, or the most obvious partial-length of median rise of each absolute construction 8 is different, now melt 9 setting positions on each absolute construction 8 preferably not on same cross section.As illustrated in fig. 21b, three absolute construction 8 are separated from each other, the length of absolute construction 8 is preferably 10--20mm, the deformation of three absolute construction 8 will make three absolute construction 8 mutually away from, generally with the head end of absolute construction 8 and neighbouring position thereof mutually away from the most obvious, now melt 9 and be preferably disposed on the head end of each absolute construction 8 and neighbouring position thereof, the length of three absolute construction 8 can not wait, because the length of three absolute construction 8 is different, therefore respectively melt 9 and first contact the position of blood vessel wall also not on same cross section, as shown in figure 23, melt a position of 9 contact renal artery d and lay respectively at a, b, on the cross section that c tri-is different, or the length of three absolute construction 8 is equal, but melt 9 different at the setting position of each absolute construction 8 head.The middle somewhere of three absolute construction 8 far-end that links together is separated from each other again, junction point 18 is preferably selected to account for the place of the longest whole absolute construction 8 length 30--50% at the longest absolute construction 8 far-end to the part of junction point 18, preferably, each absolute construction 8 length is 20--40mm, as shown in fig. 21 c, in order to make ablation points not on the same cross section of blood vessel, the length of three absolute construction 8 can not wait, but the partial-length between junction point 18 to absolute construction 8 tail end is preferably equal, the deformation of three absolute construction 8 will to make on three absolute construction 8 junction point 18 to the loose protuberance of part four of absolute construction 8 tail end, generally relatively swell the most obvious with in the middle of this part or close middle position, and junction point 18 to absolute construction 8 head end part mutually away from, generally with the head end of absolute construction 8 and neighbouring position thereof mutually away from the most obvious, six positions now will be had preferentially to contact blood vessel wall, i.e. head end and neighbouring position thereof the place the most obvious with protuberance of three absolute construction 8, now melt 9 and be preferably disposed on the head end of absolute construction 8 and neighbouring position thereof, or the length of three absolute construction 8 is equal, the partial-length between junction point 18 to absolute construction 8 tail end is also equal, now melts 9 different at the setting position of each absolute construction 8 head, as shown in fig. 21 c, swell between junction point 18 to absolute construction 8 tail end detecting electrode 19 can be set the most significantly.

As shown in figure 22, when absolute construction 8 is four, best each absolute construction 8 is arranged one and melt 9.As shown in fig. 22, the far-end of four absolute construction 8 is connected to and melts paragraph header end 17, four absolute construction 8 preferably wait large, the length of each absolute construction 8 is preferably 13--30mm, the deformation of four absolute construction 8 will make the loose protuberance of mid portion four of four absolute construction 8, form similar fusiform structure, protuberance is the most local to be generally positioned at the centre of absolute construction 8 or first will to contact blood vessel wall near middle position, the most obvious place of mid portion protuberance of each absolute construction 8 is preferably different, now melting 9, to be preferably disposed on protuberance the most local, or the most obvious partial-length of median rise of each absolute construction 8 is different, now melt 9 setting positions on each absolute construction 8 preferably not on same cross section.As shown in Figure 22 B, four absolute construction 8 are separated from each other, the length of absolute construction 8 is preferably 10--20mm, the deformation of four absolute construction 8 will make four absolute construction 8 mutually away from, generally with the head end of absolute construction 8 and neighbouring position thereof mutually away from the most obvious, the length of four absolute construction 8 can not wait, now melt 9 and be preferably arranged on the head end of absolute construction 8 and neighbouring position thereof, because the length of four absolute construction 8 is different, therefore respectively melt 9 and first contact the position of blood vessel wall also not on same cross section; Or the length of four absolute construction 8 is equal, but melt 9 different at the setting position of each absolute construction 8 head.As shown in fig. 22 c, the middle somewhere of four absolute construction 8 far-end that links together is separated from each other again, junction point 18 is preferably selected to account for the place of the longest whole absolute construction 8 length 30--50% at the longest absolute construction 8 far-end to the part of junction point 18, preferably, each absolute construction 8 length is 20--40mm, as shown in fig. 22 c, in order to make ablation points not on the same cross section of blood vessel, the length of four absolute construction 8 can not wait, but the partial-length between junction point 18 to absolute construction 8 tail end is preferably equal, the deformation of four absolute construction 8 will to make on four absolute construction 8 junction point 18 to the loose protuberance of part four of absolute construction 8 tail end, generally relatively swell the most obvious with in the middle of this part or close middle position, and junction point 18 to absolute construction 8 head end part mutually away from, generally with the head end of absolute construction 8 and neighbouring position thereof mutually away from the most obvious, eight positions now will be had preferentially to contact blood vessel wall, i.e. head end and neighbouring position thereof the place the most obvious with protuberance of four absolute construction 8, now melt 9 and be arranged on the head end of absolute construction 8 and neighbouring position thereof, or the length of four absolute construction 8 is equal, the partial-length between junction point 18 to absolute construction 8 tail end is also equal, now melts 9 different at the setting position of each absolute construction 8 head, as shown in fig. 22 c, swell between junction point 18 to absolute construction 8 tail end detecting electrode 19 can be set the most significantly.As shown in figure 22d, have two relative absolute construction 8 to be separated from each other in four absolute construction 8, and the far-end of two other relative absolute construction 8 is connected to and melts paragraph header end 17, preferably, the length of each absolute construction 8 is 13--30mm, as shown in figure 22d, being connected to for far-end two absolute construction 8 melting paragraph header end 17 preferably waits large, the deformation of these two absolute construction 8 is swelled relatively by making their mid portion, protuberance is the most local to be generally positioned at the centre of these two absolute construction 8 or first will to contact blood vessel wall near middle position, the most obvious place of mid portion protuberance of these two absolute construction 8 is preferably different, melting 9, to be preferably arranged on protuberance the most local, or the most obvious partial-length of median rise of these two absolute construction 8 is different, now melt 9 setting positions on these two absolute construction 8 preferably not on same cross section, as shown in figure 22d, can be different for two absolute construction 8 length be separated from each other, the deformation of these two absolute construction 8 will make they mutually away from, generally with the head end of these two absolute construction 8 and neighbouring position thereof mutually away from the most obvious, melt 9 and be preferably arranged on the head end of these two absolute construction 8 and neighbouring position thereof, or the length of these two absolute construction 8 is equal, and melt 9 different at the setting position of these two absolute construction 8 heads, above-mentioned design makes four to melt a position of 9 contact blood vessel wall on mutually different cross section the most at last.As shown in figure 22e, the far-end of the absolute construction 8 of four Length discrepancy is connected to the different parts of traction fiber 10, and preferably, the length of absolute construction 8 is 13--30mm, and traction fiber 10 overlaps with the long axis centerline of ablation catheter 1; When there is deformation in four absolute construction 8 under the effect of traction fiber 10, the mid portion of each absolute construction 8 is by four loose protuberances, first the most obvious place of protuberance will contact blood vessel wall, fixed position due to absolute construction 8 Length discrepancy and on traction fiber is different, therefore swelling the most obvious place also can be different, will melt 9 like this and be arranged on these and swell the most obvious places and just ensure that ablation points not on arteriorenal same cross section.In addition the cross section outline of the section of melting 6 is preferably similar to the cross section outline of controllable bending tune 5, the arrangement that each absolute construction 8 is as far as possible compact within the scope of the outline of the section of melting 6, as shown in figure 24, when absolute construction 8 is two to four, each absolute construction 8 preferably divides circle equally on cross section.Certainly along with the increase of absolute construction 8 quantity, the cross-sectional profiles of absolute construction 8 also can adopt other designs to make the arrangement as far as possible compact within the scope of the outline of the section of melting 6 of each absolute construction 8.Absolute construction 8 quantity is continued to situation about increasing, preferably adopt following design, namely the far-end of each absolute construction 8 can be connected to melt paragraph header end 17, each absolute construction 8 is separated from each other the different parts being connected to traction fiber 10 with the far-end of the absolute construction 8 of Length discrepancy, these designs can copy absolute construction 8 be three and four time corresponding design.

The Main Function arranging controllable bending tune 5 contributes to the section of melting 6 to arrive the ablation locations of specifying more easily, such as, make the section of melting 6 more easily by the bending of blood vessel, make the section of melting 6 easier to assigned direction deflection etc.Controllable bending tune 5 preferably adopts cylindrical or class cylinder design, different according to the length of different design controllable bending tunes 5.Figure 25 shows situation when controllable bending tune 5 is C shape curved design under duty, and Figure 25 is the absolute construction 8 of the section of melting 6 to be described when being two, when being other design forms for the section of melting 6, only needs the replacement section of melting 6.As shown in figure 25, shape after controllable bending tune 5 deformation is C shape, the controllable bending tune 5 of bold portion illustrates the bending situation of a kind of C shape, under this configuration, controllable bending tune 5 preferred length is 60--120mm, controllable bending tune 5 will have two local c1 and c2 and Ink vessel transfusing sidewall contact, wherein c1 contacts with the medial wall of renal artery a, and c2 contacts with the medial wall of ventral aorta b, to be conducive to like this when melting stablely melting 9, controllable bending tune 5 now preferably and one of them absolute construction 8 at grade, 9 are melted as electric pulse granting or/and the situation of collecting electrode like this for absolute construction 8 only has, detecting electrode 19 can be set at c1, formation one is provided electric pulse with the detecting electrode 19 on controllable bending tune 5 by the detecting electrode 19 melted like this on 9 or absolute construction 8, one receives electric pulse, certainly for adapting to the renal artery of different tube diameters, multiple ring-type detecting electrode 19 can be set near c1 for Received signal strength, as shown in figure 25, the controllable bending tune 5 of dotted portion illustrates the bending situation of another kind of C shape, in this case, controllable bending tune 5 preferred length is 40--100mm, controllable bending tune 5 can not contact with the medial wall of tremulous pulse, or only have a local c2 to contact with the medial wall of tremulous pulse, what melt 9 like this stablely will mainly rely on each absolute construction 8 to contact with the medial wall of tremulous pulse the strong point formed.

As the case may be, technical staff can be merged, improve and cross-reference the design of above-mentioned these sections of melting 6 and controllable bending tune 5, and these equivalence changes and modification fall into the scope of the claims in the present invention equally.

Described controllable bending tune 5, absolute construction 8 and guiding catheter 7 can have prefabricated deformation, such as shown in figure 25, in advance controllable bending tune 5 can be preset to C shape and bend, make the section of melting 6 can enter renal artery smoothly when manufacturing in vitro.Technical staff can realize adjusting prefabricated deformation in vitro by adding the material with shape memory function in controllable bending tune 5, absolute construction 8 and guiding catheter 7, such as: in controllable bending tune 5, add marmem, first its bending shape in vitro can be made C shape in advance to bend, when needs controllable bending tune 5 changes bending shape, the external curved pattern by variations in temperature, controllable bending tune 5 being made other shapes again can be taken out again.

The Main Function of described guiding catheter 7 is enclosed within to play outside ablation catheter 1 to guide ablation catheter 1 direction, hold ablation catheter 1 and provide passage for ablation catheter 1, therefore the internal diameter of guiding catheter 7 is because of bigger compared with ablation catheter 1 external diameter, and guiding catheter 7 deformation sometimes can also played as ablation catheter 1 provides the effect of fulcrum in addition.Figure 26, Figure 27, Figure 28, Figure 29 are for two absolute construction 8, show guiding catheter 7 can for the deformation of ablation catheter 1 fulcrum is provided when, the main structure of guiding catheter 7 head; Wherein Figure 26 display is the main structure of absolute construction 8 guiding catheter 7 head when being separated from each other, Figure 27 display be the situation of absolute construction 8 when being separated from each other under guiding catheter 7 and absolute construction 8 duty, Figure 28 display be the main structure that the far-end of absolute construction 8 is connected to guiding catheter 7 head when melting paragraph header end 17, Figure 29 display be that the middle somewhere of absolute construction 8 links together the main structure of far-end guiding catheter 7 head when being separated from each other again.Figure 30 is connected to for far-end two absolute construction 8 melting paragraph header end 17, show guiding catheter 7 not for the deformation of ablation catheter 1 fulcrum is provided when, the main structure of guiding catheter 7 head.

The inclined hole 74 that the situation of fulcrum, the head of guiding catheter 7 can be provided preferably to arrange communicate with blood vessel for the deformation of ablation catheter 1 for guiding catheter 7 is or/and side channel 76.The passage that inclined hole 74 and side channel 76 stretch out outside guiding catheter 7 mainly as absolute construction 8, realizes absolute construction 8 and vessel wall contact, and certain inclined hole 74 and side channel 76 also can as to Ink vessel transfusing injections or/and the passage of injection of contrast medium.The set-up mode being interconnected the inclined hole 74 of different guiding catheters 7 head of mode and side channel 76 according to absolute construction 8 quantity and par wise irrelevance structure 8 is also different.Figure 26 A, Figure 26 B, Figure 26 C are vertical section schematic diagram, and Figure 26 D, Figure 26 E are perspective diagram.As shown in figure 26, when absolute construction 8 is separated from each other, the head end (far-end) or head side wall of guiding catheter 7 output the corresponding inclined hole 74 of some and each absolute construction 8, as Figure 26 A, shown in 26D, inclined hole 74 can open the head end in guiding catheter 7, as Figure 26 B, shown in Figure 26 C, inclined hole 74 also can be opened in the head side wall of guiding catheter 7, the internal diameter of each inclined hole 74 is greater than the external diameter of absolute construction 8, general 1.4--2.4mm, the angle of inclination of each inclined hole 74 is generally 30--50 degree, the quantity of inclined hole 74 preferably equals the quantity of absolute construction 8 simultaneously, coupling part 75 between inclined hole 74 is preferably in taper, coupling part 75 can not only limit controllable bending tune 5 and also be contributed to guiding absolute construction 8 from inclined hole 74 by front release by front release guiding catheter 7.If push ablation catheter 1 or rollback guiding catheter 7, as shown in Figure 26 C, Figure 27, absolute construction 8 outwards will be pushed into blood vessel in divergence shape in inclined hole 74, and melting of absolute construction 8 head 9 will preferential and vessel wall contact; By controlling to push ablation catheter 1 or the distance of rollback guiding catheter 7 and the gradient of inclined hole 74, distance that absolute construction 8 far-end is separated from each other can be controlled and melt 9 with the pressure of vessel wall contact.Far-end for absolute construction 8 comes together in the situation melting paragraph header end 17, and Figure 28 A, Figure 28 B are vertical section schematic diagram, and Figure 28 C is perspective view.As shown in Figure 28 A, Figure 28 C, when the far-end of absolute construction 8 come together in melt paragraph header end 17 time, the head end opening of guiding catheter 7 limits preferably by the mode of structural design and melts paragraph header end 17 by front release guiding catheter 7, the external diameter (shown in Figure 28 A) that throat structure 73 makes the aperture of guiding catheter 7 head end opening be less than to melt paragraph header end 17 preferably can be set, or with the head end opening (Figure 28 B, Figure 28 C are shown) of plug 72 confined bed guiding tube 7; As shown in figure 28, the head end sidewall of guiding catheter 7 is preferably provided with the similar length of absolute construction 8 and the side channel 76 communicated with blood vessel, the length of side channel 76 is generally 12--28mm, this side channel 76 is preferably parallel corresponding with absolute construction 8, the width of side channel 76 is slightly larger than the external diameter of absolute construction 8, be generally 1.4--2.4mm, and the quantity of side channel 76 preferably equals the quantity of absolute construction 8.If push ablation catheter 1 or rollback guiding catheter 7, as shown in Figure 28 B, melt paragraph header end 17 because the restriction of plug 72 will make absolute construction 8 from the bulging of corresponding side channel 76 protuberance, will make to melt 9 and preferentially contact with blood vessel wall; By controlling the distance pushing ablation catheter 1 or rollback guiding catheter 7, spacing distance that absolute construction 8 mid portion swells relatively can be controlled and melt 9 with the pressure of vessel wall contact.Middle somewhere for absolute construction 8 links together the situation that far-end is separated from each other again, and the design of guiding catheter 7 head combines Figure 26, Figure 27, design illustrated in Figure 28.As shown in figure 29 a, the head side wall of guiding catheter 7 is arranged and somely communicates with blood vessel inclined hole 74 little or some little inclined hole 74 (similar Figure 26 A are set at the head end of guiding catheter 7, shown in Figure 26 D), then after the inclined hole 74 guiding catheter 7 of certain distance sidewall on and that with absolute construction 8 parallel side channel 76 corresponding with inclined hole 74 is set again, inclined hole 74 is generally 2.5--5.5mm with the spacing distance of side channel 76, the internal diameter of each inclined hole is slightly larger than the external diameter of absolute construction 8, be generally 1.4--2.4mm, the angle of inclination of each inclined hole 74 is generally 30--50 degree, coupling part 75 between inclined hole is preferably in taper, coupling part 75 can not only limit junction point 18 and controllable bending tune 5 is also contributed to guiding absolute construction 8 from inclined hole 74 by front release by front release guiding catheter 7, the width of side channel 76 is preferably slightly larger than the external diameter of absolute construction 8, be generally 1.4--2.4mm, the length of side channel 76 and absolute construction 8 near-end are to the similar length of the part of junction point 18, be generally 10--22mm, the quantity of inclined hole 74 and side channel 76 preferably equals the quantity of absolute construction 8.If push ablation catheter 1 or rollback guiding catheter 7, as shown in fig. 29b, part between absolute construction 8 far-end to junction point 18 outwards will be pushed into blood vessel in divergence shape in inclined hole 74, melting of absolute construction 8 head 9 will preferential and vessel wall contact, part between absolute construction 8 near-end to junction point 18 will swell bulging from the side channel 76 of correspondence, protuberance is the most local will preferential and vessel wall contact; By control to push ablation catheter 1 or the distance of rollback guiding catheter 7 and the gradient of inclined hole 74 and can control distance that absolute construction 8 far-end is separated from each other and melt 9 with the pressure of vessel wall contact.The absolute construction 8 that part is relative to be separated from each other and the far-end of the relative absolute construction 8 of part is connected to the situation melting paragraph header end 17, also can use for reference the thinking of Figure 26, Figure 27, Figure 28, guiding catheter 7 head design scheme illustrated in Figure 29, inclined hole 74 and side channel 76 are preferably set at the head of guiding catheter 7 simultaneously, it is corresponding and be preferably arranged on the sidewall of guiding catheter 7 head that inclined hole 74 and far-end are connected to the absolute construction 8 melting paragraph header end 17, but also can be arranged on the opening part of guiding catheter 7 head end, side channel 76 is corresponding with the absolute construction 8 be separated from each other and be preferably arranged on apart from the sidewall of the guiding catheter 7 of inclined hole 74 certain distance, side channel 76 and inclined hole 74 absolute construction 8 not on the same line and respectively with corresponding is corresponding, for four absolute construction 8, two inclined holes 74 are on two sidewalls up and down of guiding catheter 7 head, two side channels 76 are then on the sidewall of two, the left and right of guiding catheter 7 head, the size of each inclined hole 74 can allow absolute construction 8 pass through, be generally 1.4--2.4mm, the quantity of inclined hole 74 preferably equals the quantity of the absolute construction 8 be separated from each other simultaneously, coupling part 75 between inclined hole 74 is preferably in taper, coupling part 75 can not only limit melts paragraph header end 17 and controllable bending tune 5 and is also contributed to guiding the absolute construction 8 that is separated from each other from inclined hole 74 by front release by front release guiding catheter 7, the width of side channel 76 is greater than the maximum transverse diameter of absolute construction 8, be generally 1.4--2.4mm, side channel 76 and far-end come together in the similar length of the absolute construction 8 melting paragraph header end 17, be generally 12--28mm, the quantity of side channel 76 preferably equals the quantity that far-end comes together in the absolute construction 8 melting paragraph header end 17, if push ablation catheter 1 or rollback guiding catheter 7, for the absolute construction 8 be separated from each other, they outwards will be pushed into blood vessel in divergence shape in inclined hole 74, melting of absolute construction 8 head 9 will preferential and vessel wall contact, for being connected to the absolute construction 8 melting paragraph header end 17, these absolute construction 8 will be made owing to melting paragraph header end 17 to swell bulging from corresponding side channel 76 by the restriction of the coupling part between inclined hole 74, and make to melt 9 and preferentially contact with blood vessel wall.Inclined hole 74 in above-mentioned design and side channel 76 also have the effect to Ink vessel transfusing injection or injection of contrast medium.Conveniently absolute construction 8 forms design deformation, can by adjusting the structural design of absolute construction 8 or making design deformation more easily realize by changing manufactured materials hardness.Figure 26, Figure 27, Figure 28, Figure 29 carry out design explanation for two absolute construction 8, therefore be not limited to the situation of two rule absolute construction 8, quantity according to Figure 26, Figure 27, Figure 28, mentality of designing illustrated in Figure 29 adjustment inclined hole 74 and side channel 76 and setting position are only needed for the situation more than two absolute construction 8.

The situation of fulcrum can not be provided for the deformation of ablation catheter 1 for guiding catheter 7, absolute construction 8 preferably arranges prefabricated deformation, controllable bending tune 5 can arrange prefabricated deformation, then ablation catheter 1 is pressed in guiding catheter 7, after the head end of guiding catheter 7 arrives assigned address, ablation catheter 1 can be out pushed from the opening of guiding catheter 7 head end, recovers prefabricated deformation.As shown in fig. 30 a, far-end is come together in two absolute construction 8 melting paragraph header end 17 and be prefabricated into class subfusiform, be pressed in guiding catheter 7 by this ablation catheter 1, due to the restriction of guiding catheter 7, the mid portion being prefabricated into fusiform two absolute construction 8 will be drawn close mutually.As shown in figure 30b, when guiding catheter 7 arrives the opening part of renal artery a on aorta b, push out in guiding catheter 7 head end opening by the section of melting 6, now two absolute construction 8 will revert to prefabricated class subfusiform, attachment melt 9 ledge will preferential and vessel wall contact.As shown in Figure 30 C, when controllable bending tune 5 is prefabricated into C shape, guiding catheter 7 can push out close to being about to the section of melting 6 during the opening part of renal artery a on aorta b in guiding catheter 7 head end opening, due to the existence that the C shape of controllable bending tune 5 is bending, the section of melting 6 also can enter renal artery a from aorta b smoothly.Figure 30 is connected to for far-end two absolute construction 8 melting paragraph header end 17 to carry out design explanation, therefore the situation of two absolute construction 8 is not limited to, also be not limited to absolute construction 8 far-end and be connected to the connected mode melting this kind of par wise irrelevance structure 8 of paragraph header end 17, be suitable for too for more than other connected mode of the situation of two absolute construction 8 and par wise irrelevance structure 8, such as the absolute construction 8 be separated from each other, need absolute construction 8 to be prefabricated into head end and neighbouring position thereof mutually away from the most obvious state, then guiding catheter 7 is pressed into, such as the middle somewhere of absolute construction 8 is linked together the situation that far-end is separated from each other again again, partial precast between needing absolute construction 8 far-end to junction point 18 becomes with head end and neighbouring position thereof mutually away from the most obvious state, and the partial precast between absolute construction 8 near-end to junction point 18 is become spindle, then guiding catheter 7 is pressed into, such as the absolute construction 8 that part is relative to be separated from each other again and the far-end of the relative absolute construction 8 of part is connected to the situation melting paragraph header end 17, need the absolute construction 8 be separated from each other to be prefabricated into head end and neighbouring position thereof mutually away from the most obvious state, and far-end is connected to the absolute construction 8 melting paragraph header end 17 and is prefabricated into spindle, then guiding catheter 7 is pressed into.In addition also at the head of guiding catheter 7, the inclined hole 74 corresponding with absolute construction 8 can be set or/and side channel 76, when release guiding catheter 7, also can realize absolute construction 8 and recover prefabricated deformation before not by the section of melting 6 like this.

Figure 31, Figure 32 show the mode being changed ablation catheter 1 and the distribution of guiding catheter 7 hardness in the present invention by structural design.This by structural design change ablation catheter 1 do not require that the hardness of the manufactured materials of various piece itself is different with the mode that guiding catheter 7 hardness distributes.

As Figure 31 A, shown in Figure 31 B, in ablation catheter 1 inside, the chicken ribs spline structure shown in Figure 31 A and Figure 31 B is set, namely d5 distance in interval arranges a cross section for the structure shown in Figure 31 B, the part that this structure bend represents is had certain elastic material to fill, preferred high molecular polymer, white space a1 in ablation catheter 1 by formation chamber, be mainly used in wire, fine duct, the travelings such as optical fiber, certain white space a1 is not limited to circle, also be not limited to and only have a chamber, according to circumstances can be arranged to other shapes (such as oval, rectangle etc.), the more chamber component that traveling is different respectively also can be set.As shown in Figure 31 A, Figure 31 B, white space b1 in ablation catheter 1 also by formation chamber, also can traveling wire, fine duct, optical fiber etc., such white space a1, b1 just can distinguish the different component of traveling, certain white space b1 is not limited to semicircle, also be not limited to and only have a chamber, according to circumstances can be arranged to other shapes (such as ellipse, rectangle etc.), the more chamber component that traveling is different respectively also can be set.As shown in fig. 3 ia, owing to lacking the arcuate structure in Figure 31 B in d3 and d4 institute inclusion region in the region included by d5, therefore on y direction, region included by each d5 will easily bend, and the structure made shown in Figure 31 A is formed integrally bending by the bending of the region included by all d5.Similarly, as shown in Figure 31 C, the white space of b1 sample in two Figure 31 B is set in the region included by d3, d4, d3', d4', i.e. white space b1, b2, and now white space a1 between white space b1, b2, be in (mainly in the region that d2 and d2' surrounds) in the region included by d1, structure in Figure 31 A in region included by d6 substitutes by the structure shown in Figure 31 C, and structure in Figure 31 A in region included by d5 will be the extension of structure in Figure 31 C in region included by d1; White space a1 is by formation chamber in ablation catheter 1, and for travelings such as wire, fine duct, optical fiber, certain white space a1 is not limited to ellipse, and being also not limited to only has a chamber; White space b1 and b2 in ablation catheter 1 also by formation two chambers, also can traveling wire, fine duct, optical fiber etc., certain white space b1 and b2 is not limited to semicircle, and being also not limited to only has a chamber respectively; Owing to lacking the arcuate structure in Figure 31 C in region included by d3, d4, d3', d4' in the region included by d5, therefore on y direction, region included by each d5 will easily bend, the bending of region included by all d5 will make structure shown in Figure 31 A form integrally bending, now because d5 both sides all lack supporting construction, therefore can there is compound bending, and make the complexity to both direction is bending different by the large young pathbreaker of adjustment white space b1 with b2; Certainly, also can arrange the b1 sample white space that three Figure 31 B illustrate similarly on three different directions, to realize the bending of at least three directions, and this project organization can also be by that analogy.As shown in Figure 31 D, Figure 31 E, when the cross section of some part of ablation catheter 1 is not circular, chicken ribs spline structure can realize equally in these ablation catheter 1 parts, Figure 31 D, Figure 31 E describe the implementation of chicken ribs spline structure in other shapes than circular for semicircular structure, according to the difference of bending direction, the position that white space a1 and b1 arranges is different.Such as, as fig. 3 id, white space b1 is arranged in the left side of white space a1, structure in Figure 31 A in region included by d6 substitutes by the structure shown in Figure 31 D, and structure in Figure 31 A in region included by d5 will be the extension of structure in Figure 31 D in region included by d1, whole like this stereochemical structure will easily to white space b1 lateral bend; As shown in Figure 31 E, b1 is arranged in the right of a1, structure in Figure 31 A in region included by d6 substitutes by the structure shown in Figure 31 E, and structure in region included by d5 will be the extension of structure in Figure 31 E in region included by d1, whole like this stereochemical structure will easily to white space b1 lateral bend.In the structure shown in Figure 31, by changing size, the quantity of white space a1, b1, b2, and by changing the size of d1, d2, d3, d4, d5, d6, the difference of each section of hardness can be realized, widen d1 for a certain section such as in Figure 31 A, reducing d3 or d4 will make this section be not easy deformation, more such as a certain section is widened d5 and will make, the easier deformation of this section; Can be realized by the relative position changing white space a1 and b1 region in different section that different section is non-to be bent in the same way, such as by the Lower Half horizontal rotary turnback of Figure 31 A institute schematic construction, to make the arrow side of Lower Half white space b1 in Figure 31 A, the structure after improving like this will contribute to realizing S shape and bend.In a word, the essence of chicken ribs spline structure is by optionally reducing or/and increase the internal structure of some conduit segment and then optionally reduce or/and improve the bending resistance of a certain side of the little intrasegmental part of some conduit or a few side, to make conduit easier to be bending or/and form some bending shape to some direction.

Figure 32 to show in embodiments of the invention another kind of designed by change structure and then change hardness distribution make the bending design more easily realized.This project organization is the implementation of chicken ribs spline structure in hollow tubular structure, and this kind of structure is preferred for hollow pipe spline structure (such as guiding catheter 7 etc.).This structure is mainly through changing the arrangement in different conduit segment of metal gauze in ablation catheter 1 and guiding catheter 7 tube wall or ablation catheter 1 and the thickness of guiding catheter 7 tube wall in different conduit segment realizes by changing, certainly metal gauze described here is construed as the project organization reinforcing duct wall hardness, it also can be such as macromolecular material net etc., therefore the essence of this kind of design is by optionally reducing or/and increase the structure of some conduit segment tube wall and then optionally reduce or/and improve certain side of some conduit segment tube wall or the bending resistance of a few side, to make conduit easier to be bending or form some bending shape to some direction.Figure 32 changes the arrangement in different conduit segment of metal gauze in ablation catheter 1 or guiding catheter 7 tube wall for example to be described.As shown in fig. 32 a, in figure, netting twine represents metal gauze, can see from the lower-left figure of Figure 32 A, metal gauze in duct wall covers duct wall completely, can see from the picture left above of Figure 32 A, do not have metal gauze in the side tube wall of conduit, two little spacer segments of conduit are stacked together, the structure shown in right figure of pie graph 32A, does not have metal gauze in the side tube wall due to a bit of conduit of top, therefore the easier curving to not having metal gauze of conduit.Certainly the design not having metal gauze in the side tube wall of conduit is also not limited to, as shown in fig. 32d, four S shape tinsel f1 are had between the conduit segment that two have complete metal gauze, f2, f3, f4, can at f1, between f2 and f3, between f4, metal gauze is set, and at f2, between f3 and f1, between f4, metal gauze is not set, easier two lateral bends to not having metal gauze of such conduit, in like manner also can at the metal gauze often only arranging half between adjacent two S shape tinsels, such conduit is easier in not having the four direction of metal gauze to bend, four S shape tinsels can also be only had and there is no metal gauze, whole like this conduit will easily bend to multiple directions.In addition be also not limited to the situation that certain side of some conduit segment tube wall or a few side do not have metal gauze, this can be realized certain side of some conduit segment tube wall by the mode such as aperture, density, width wiry changing metal gauze or a few side soft compared with other catheter walls or hard; According to circumstances S shape quantity wiry can adjust, and S shape tinsel also can be other forms simultaneously, such as " Z " shape etc.The structure of Figure 32 A can see figure arrangement according to the side shown in Figure 32 B, and the bending direction of whole like this run will be consistent; The structure of Figure 32 A can see figure arrangement according to the side shown in Figure 32 C, the bending direction of whole like this run top and the bottom is inconsistent, just can realize complicated bend by a guide wire 70 in this way, such as, guide wire 70 region that d3 and d3' intersects from Figure 32 C be bent through more easily realizing S shape.As shown in Figure 32 B and Figure 32 C, the bending complexity of each section of conduit can also be changed by the width adjusting d1, d3, d3', d4, d5.In addition total is also not limited to conduit cross section is circular situation, still can design according to this thinking when conduit cross section is the shape such as semicircle, square, but now need to consider the impact of these shapes on guide wire 70 and the hardness of chicken ribs spline structure own.

The mode being changed ablation catheter 1 and guiding catheter 7 hardness by structural design shown by Figure 31, Figure 32, can also be realized by the hardness changing manufactured materials, the cross section of each segment of such as conduit can be all designs of Figure 32 B, but the area manufacturing material on the cross section of some segment included by d3, d4 comparatively other segments is hard, and so these segments will be less likely to occur to bend.

Figure 33 is connected to for two absolute construction 8 far-ends to melt paragraph header end 17, shows in the present invention and how by the hardness distribution of adjustment absolute construction 8, the deformation of design more easily to be realized.As shown in figure 33 a, article two, absolute construction 8a, 8b bending shape is symmetrical each other, conveniently outwards relatively swell for semi-cylindrical two absolute construction 8a, 8b, Figure 31 can be adopted or/and chicken ribs spline structure illustrated in Figure 32, when adopting chicken ribs spline structure illustrated in Figure 31, absolute construction 8 can adopt the design shown in Figure 31 D, and wherein the form of the cross section shown in dotted line cc is preferably shown in Figure 31 D; When adopting chicken ribs spline structure illustrated in Figure 32, the blank parts in absolute construction 8 is interpreted as the structural rigidity reduction that absolute construction 8 tube wall keeps at a certain distance away, such as, by removing metal gauze, changing the density etc. of metal gauze.As shown in Figure 33 B, Figure 33 C, Figure 33 D, the bending shape of two absolute construction 8 also can be asymmetric, and this is for absolute construction 8 more than being very necessary when two, and it contributes to making ablation points be on different renal artery cross sections; The chicken ribs spline structure illustrated with Figure 33 A is similar, the design that Figure 33 B, Figure 33 C, Figure 33 D illustrate also can adopt Figure 31 or/and chicken ribs spline structure illustrated in Figure 32, in order to realize different bending shapes, the difference of each section of hardness can be realized by the arrangement of chicken ribs spline structure on each absolute construction 8 of adjustment, the local hardness larger in curvature is preferably less, more easily realizes bending.In Figure 33, the blank parts of absolute construction 8a, 8b represents the part that on each absolute construction 8, hardness is less, therefore can be changed the hardness distribution of chicken ribs spline structure by the size, form, branch's density etc. of the upper blank parts of adjustment absolute construction 8a, 8b, and then change bending shape.As shown in Figure 33 B, melt in absolute construction 8a in a part of 9 to absolute construction 8a tail end and absolute construction 8b and melt 9 comparatively large to the part curvature melting paragraph header end 17, therefore blank parts is also larger and closeer.Similarly, in Figure 33 C, in order to realize absolute construction 8 deformation, latter two melts 9 equal to the distance of the section of melting 6 long axis centerline, when two absolute construction 8 length are equal, absolute construction 8b has been designed to that near-end is not flexible and far-end and mid portion easily bend, therefore the far-end of absolute construction 8b and mid portion blank parts also more intensive, make it more flexible.In Figure 33 D, absolute construction 8 deformation latter two melt 9 unequal to the distance of the section of melting 6 long axis centerline, when two absolute construction 8 length are equal, the most significantly the length of part on two absolute construction 8 is different in the median rise of absolute construction 8, the most significantly part is longer in the median rise of absolute construction 8b, these other part curvature just requiring absolute construction 8b are larger, more flexible, therefore the blank parts of the far-end of absolute construction 8b and near-end also more greatly, more intensive.As shown in figure 33, the shape of blank parts also can be changeable, can be Figure 33 A, Figure 33 C, the shape shown in Figure 33 D, also can be the shape shown in Figure 33 B, and certain technical staff can also according to other shapes of concrete actual design.Figure 33 carries out design explanation for two absolute construction 8, is therefore not limited to the situation of two absolute construction 8, is suitable for too for the situation more than two absolute construction 8.In addition the blank parts in Figure 33 on absolute construction 8 is interpreted as the structural rigidity that absolute construction 8 keeps at a certain distance away and reduces, and this hardness mode that not only can be designed by change structure that declines realizes also to be realized by the mode of change material hardness.Need absolute construction 8 to form the situation of other bending shapes for technical staff, can adjust accordingly the blank parts of absolute construction in Figure 33 8.

Figure 35 is for two absolute construction 8, shows when absolute construction 8 is separated from each other in embodiments of the invention and how by the hardness distribution of adjustment absolute construction 8, the deformation of design more easily to be realized.The meaning that blank parts in Figure 35 on absolute construction 8 represents is interpreted as the structural rigidity reduction that absolute construction 8 keeps at a certain distance away, this hardness is reduced the mode that not only can be designed by change structure and realizes also to realize by changing the mode of material hardness, and the hardness distribution that therefore can change absolute construction 8 by the size, form, distribution density etc. of adjustment blank parts makes it more flexiblely become required form.Similar to the structural design thinking that absolute construction 8 illustrated in Figure 33 is connected to when melting paragraph header end 17, design illustrated in Figure 35 preferably adopts chicken ribs spline structure, adopts shown in Figure 31 or/and the chicken ribs sample design shown in Figure 32.As shown in figure 35, in the part near absolute construction 8 head end, blank parts is preferably arranged on the part of absolute construction 8 by the section of melting 6 centrage, and at the mid portion of absolute construction 8 and afterbody, blank parts is preferably arranged on the part of absolute construction 8 away from the section of melting 6 centrage; Blank parts all can certainly be arranged on absolute construction 8 by the part of the section of melting 6 centrage or absolute construction 8 part away from the section of melting 6 centrage.Figure 35 B, Figure 35 C illustrate how to realize ablation points on different renal artery cross sections for two absolute construction 8.As shown in Figure 35 B, not etc., the length due to two absolute construction 8 is not different and melt the head that 9 are all arranged on every bar absolute construction 8, therefore, it is possible to realize ablation points on different renal artery cross sections for the length of two absolute construction 8a, 8b.As shown in Figure 35 C, article two, the length of absolute construction 8a, 8b also can be equal and internal structure is mirror symmetry substantially, just melt 9 attachment position different, absolute construction 8a melts the far-end of a 9a closer to absolute construction 8, also can realize ablation points in this way on different renal artery cross sections.Figure 35 carries out design explanation for two absolute construction 8, is therefore not limited to the situation of two absolute construction 8, is suitable for too for the situation more than two absolute construction 8.In addition need absolute construction 8 to form the situation of other bending shapes for technical staff, can adjust accordingly the blank parts of absolute construction in Figure 35 8.

Figure 36, Figure 37 are for two absolute construction 8, and how the middle somewhere showing absolute construction 8 makes the deformation of design more easily realize by the hardness distribution of adjustment absolute construction 8 if linking together when far-end is separated from each other again.The meaning that blank parts in Figure 37 on absolute construction 8 represents is interpreted as the structural rigidity reduction that absolute construction 8 keeps at a certain distance away, this hardness is reduced the mode that not only can be designed by change structure and realizes also to realize by changing the mode of material hardness, and the hardness distribution that therefore can change absolute construction 8 by the size, form, distribution density etc. of adjustment blank parts makes it more flexiblely become required form.As shown in figure 36, when absolute construction 8 is two, the junction point 18 of two absolute construction 8 can be made and connect joint, connect joint and by breechblock e, semi-cylindrical absolute construction 8a, 8b are linked together, and can relatively rotate; When propelling movement ablation catheter 1 or rollback guiding catheter 7 make the coupling part 75 between the connection joint contact at junction point 18 place to guiding catheter 7 head inclined hole 74, article two, absolute construction 8 far-end will mutually away from, be attached to absolute construction 8 head melt 9 will with vessel wall contact; Larger with vessel wall contact area in order to make to melt 9, as shown in figure 36, the semi-cylindrical direction of head of two absolute construction 8 is horizontal semi-cylindrical, and other parts of absolute construction 8 are longitudinal semi-cylindrical; More easily formed to make the bending shape shown in Figure 36, equally also can adopt chicken ribs spline structure, outer absolute construction 8b due to curved openings downward, therefore can keep at a certain distance away and the part that hardness weakens is set in the downside of absolute construction 8b, similarly, inner absolute construction 8b due to curved openings upwards, therefore can keep at a certain distance away and the part that hardness weakens is set in the upside of absolute construction 8a; According to chicken ribs spline structure illustrated in Figure 31, in Figure 36, the enlarged section of dotted line cc1, cc2 cross section is the semicircle little figure of upper and lower two width in Figure 36, then in Figure 31 A, namely the horizontal figure in cross section of region absolute construction 8a, 8b in Figure 36 included by d6 is respectively the semicircle little figure of upper and lower two width in Figure 36.Similar to the structural design thinking that absolute construction 8 illustrated in Figure 33 is connected to when melting paragraph header end 17, design illustrated in Figure 37 also preferably adopts chicken ribs spline structure, adopts shown in Figure 31 or/and the chicken ribs sample design shown in Figure 32.As shown in figure 37, in the part near absolute construction 8 head end, blank parts is preferably arranged on the part of absolute construction 8 by the section of melting 6 centrage, thereafter the part of junction point 18 is arrived, blank parts is preferably arranged on the part of absolute construction 8 away from the section of melting 6 centrage, in the part of junction point 18 to absolute construction 8 end, blank parts is preferably arranged on the part of absolute construction 8 by the section of melting 6 centrage; Blank parts all can certainly be arranged on absolute construction 8 by the part of the section of melting 6 centrage or absolute construction 8 part away from the section of melting 6 centrage, and technical staff according to circumstances can adjust to the setting position of blank parts.Figure 37 B, Figure 37 C illustrate how to realize ablation points on different renal artery cross sections for two absolute construction 8.As illustrated in figure 37b, article two, the length of absolute construction 8a, 8b is not etc., but junction point 18 is equal to the partial-length of absolute construction 8 tail end, length due to two absolute construction 8 is different and melt the head that 9 are all arranged on every bar absolute construction 8, therefore also can realize ablation points on different renal artery cross sections.As shown in figure 37 c, article two, the length of absolute construction 8a, 8b also can be equal and internal structure is mirror symmetry substantially, just melt 9 attachment position different, absolute construction 8a melts the far-end of a 9a closer to absolute construction 8, ablation points can be realized in this way on different renal artery cross sections.Figure 37 carries out design explanation for two absolute construction 8, is therefore not limited to the situation of two absolute construction 8, is suitable for too for the situation more than two absolute construction 8.In addition need absolute construction 8 to form the situation of other bending shapes for technical staff, can adjust accordingly the blank parts of absolute construction in Figure 37 8.

Part absolute construction 8 far-end is connected to and melts paragraph header end 17 and the situation that part absolute construction 8 is separated from each other, the design of Figure 33, absolute construction 8 illustrated in Figure 35 can be merged, namely far-end is connected to the absolute construction 8 melting paragraph header end 17 and adopts design illustrated in Figure 33, and the absolute construction 8 be separated from each other adopts design illustrated in Figure 35.

It is how by the hardness distribution of adjustment controllable bending tune 5, design deformation more easily to be realized that Figure 34 shows embodiments of the invention, and wherein Figure 34 B, Figure 34 C are the side view after controllable bending tune 5 amplifies.Blank parts in Figure 34 on controllable bending tune 5 is interpreted as the structural rigidity reduction that controllable bending tune 5 keeps at a certain distance away, the decline mode that not only can be designed by change structure of this hardness realizes also to be realized by the mode changing material hardness, and the hardness distribution that therefore can change controllable bending tune 5 by the size, form, branch's density etc. of blank parts on adjustment controllable bending tune 5 makes it more flexiblely become required form.Similar with the design of absolute construction 8 illustrated in Figure 33, controllable bending tune 5 also preferably adopts chicken ribs spline structure; When adopting the chicken ribs spline structure shown in Figure 31, controllable bending tune 5 can adopt the design shown in Figure 31 A and Figure 31 B, and wherein in Figure 34 B, the section morphology of the cross section shown in dotted line cc1 is preferably shown in Figure 31 B; When adopting the chicken ribs spline structure shown in Figure 32, in Figure 34 A, Figure 34 B, Figure 34 C, the blank parts of controllable bending tune 5 is interpreted as the structural rigidity decline that controllable bending tune 5 tube wall keeps at a certain distance away, such as, by removing metal gauze, changing the density etc. of metal gauze; If desired bending direction contrary with the direction shown in Figure 34 B arrow ao1 (i.e. direction shown in arrow ao2), then can adopt the design shown in Figure 34 C.If desired controllable bending tune 5 all bends than being easier to both sides, can adopt the design shown in Figure 34 D, and namely the preferred both sides relative at controllable bending tune 5 arrange Figure 31 respectively or/and chicken ribs spline structure illustrated in Figure 32; When adopting chicken ribs spline structure illustrated in Figure 31, shown in the similar Figure 31 C of its design, just the size in each region slightly adjusts (as shown in Figure 34 D middle graph), and because the integral hardness of bendable control tune 5 both sides is smaller, controllable bending tune 5 is easier to two lateral bends; When adopting chicken ribs spline structure illustrated in Figure 32, in Figure 34 D, the blank parts of controllable bending tune 5 is interpreted as the structural rigidity decline that controllable bending tune 5 tube wall keeps at a certain distance away, such as, by removing metal gauze, changing the density etc. of metal gauze.As shown in the left and right two width side view of Figure 34 D, the arrangement not necessarily full symmetric of both sides chicken ribs spline structure, can have certain dislocation.Multi-direction bending (being more than or equal to 3 directions) is realized for needs, can the expansion design of chicken ribs spline structure illustrated in Figure 31 and the chicken ribs spline structure shown in Figure 32 D can be adopted to help the realization of multi-direction bending by empty bending section 5.In addition need bendable control tune 5 to form the situation of other bending shapes for technical staff, can adjust accordingly the blank parts of controllable bending tune 5 in Figure 34.

In addition, Figure 33, Figure 34, Figure 35, Figure 36, blank parts illustrated in Figure 37 are formed except the effect of design deformation except contributing to ablation catheter 1, can also cushion the pressure of ablation catheter 1 pair of blood vessel, play the effect of protection blood vessel.

For the ACTIVE CONTROL deformation of guiding catheter 7, preferred intellectual material at present, wherein better with the marmem that technology is comparatively ripe, certainly also can select the intellectual material such as electroactive polymer, magnetic living polymer according to technical requirement.Marmem being designed to the structures such as spiral type, " Z " font, " G " font implants in the tube wall of guiding catheter 7, by the temperature of the adjustable shape memorial alloys such as electric current, reaches the object controlling guiding catheter 7 deformation.Figure 38 shows the situation adopting marmem to realize ACTIVE CONTROL deformation.As shown in fig. 38 a, marmem is designed to spiral type, as spring-like, when electrified regulation, spiral in shape memorial alloy straight under room temperature, will bend, and this kind of structure is generally used for bend in one direction and the bending situation of distorted shape.As shown in fig. 38b, marmem is designed to " Z " font and " G " font.As shown in Figure 38 C, according to the original shape of marmem, when electrified regulation, " Z " character form structure can occur to stretch or compression.Figure 38 D realizes the method controlling multi-direction bending under showing ACTIVE CONTROL deformation, be about on three different directions of " Z " character form structure difference implantation catheter wall, during " Z " character form structure when electrified regulation on some directions, conduit will bend to some directions, during " Z " character form structure when electrified regulation on adjacent direction, conduit bends producing the direction of making a concerted effort to " Z " character form structure in both direction, certainly according to practical situation, the quantity of " Z " character form structure implantation catheter wall can be adjusted, direction etc., to realize the Bending Deformation of more than conduit both direction and both direction.During owing to heating marmem, temperature is generally higher than human body temperature, and therefore the outer surface of conduit preferably selects adiabator or heat insulating construction.The project organization of marmem is never confined to spiral type, " Z " font, " G " character form structure, can also design other structures according to actual needs.Be the situation of other shapes for conduit, the design that marmem illustrated in Figure 38 can be copied to realize the deformation of conduit ACTIVE CONTROL designs.In addition also can use guide wire 70 instead marmem manufacture, also can realize the control to guiding catheter 7 deformation by guide wire 70 length variations.

Figure 39 shows the main structure of guiding catheter 7 afterbody in embodiments of the invention.As shown in Figure 39 A, according to actual needs, the end (tail end, near-end) of guiding catheter 7 can be provided with perforate 77, perforate 77 is connected with syringe or priming device after being connected with one section of conduit 20, therefore by the Ink vessel transfusing injection of perforate 77 row or injection Intravascular contrast agents, when perforate 77 does not use, conduit 20 is closed.As shown in figure 39, the afterbody of guiding catheter 7 preferably has Seal Design, such as sealing ring or sealing shroud 79, anti-Hemostatic Oral Liquid spills and prevents to spill to the medicine of intravascular injection or the contrast agent of injection through guiding catheter 7 through guiding catheter 7, wherein Figure 39 A, Figure 39 B display is the situation not inserting ablation catheter 1, what Figure 39 C showed is the situation inserting ablation catheter 1, and Figure 39 B, Figure 39 C are the enlarged drawing of guiding catheter 7 afterbody; As shown in figure 39, preferably there is rigidized cover 78 around the afterbody of guiding catheter 7 in addition, make the not easily deformation of guiding catheter 7 afterbody, convenient operation, simultaneously also conveniently carry out being connected or being attached in other structures with other structures.Unidirectional or multidirectional ACTIVE CONTROL deformation also can occur guiding catheter 7 itself or/and Passive Control deformation, also can arrange prefabricated deformation simultaneously.As shown in Figure 39 A, guiding catheter 7 is only had to the situation of prefabricated deformation, preferably do not arrange guiding catheter control handle 27 (aftermentioned), its end can only arrange jointing 71, and jointing 71 can be connected with syringe, priming device, ablation catheter 1 etc.The ACTIVE CONTROL deformation of guiding catheter 7 realizes preferably by adding intellectual material (as marmem) on the tube wall of guiding catheter 7, such as: the marmem design distribution scheme adopting Figure 38 D to illustrate.The Passive Control deformation of guiding catheter 7 realizes preferably by line traffic control structural design and magnetron configuration design; Wherein line traffic control structural design realizes by penetrating guide wire 70 in the tube wall of guiding catheter 7; In addition conveniently guiding catheter 7 forms the deformation form needed, and can also change the hardness distribution of catheter guide tube 7.Figure 40 shows the main structure of guiding catheter 7 line traffic control structural design in the present invention and how to promote that guiding catheter 7 forms required deformation form by the hardness distribution of adjustment guiding catheter 7.In the line traffic control structure of guiding catheter 7 is established, preferably control guiding catheter 7 in the mode increasing guide wire 70 tension force (i.e. tractive guide wire 70 or front other parts sending guiding catheter 7 except guide wire 70), certain technical staff also can according to circumstances control guiding catheter 7 in the mode increasing guide wire 70 stress (namely pushing guide wire 70 or rollback guiding catheter 7 other parts except guide wire 70).As shown in fig. 40, guide wire 70 is provided with in the side tube wall of guiding catheter 7, when increasing the tension force of guide wire 70, guiding catheter 7 bends to the side arranging guide wire 70, also i.e. direction shown in arrow ao1 in figure, bends can arrange guide wire 70 respectively on several directions of guiding catheter 7 if guiding catheter 7 needs to realize multidirectional control.Conveniently guiding catheter 7 forms the deformation form needed, and can change the hardness distribution of guiding catheter 7 segment, and the mode that the change of this hardness distribution not only can be designed by change structure realizes also to be realized by the mode changing material hardness; Figure 40 B, Figure 40 C are the structural designs that change guiding catheter 7 segment for example is described, in Figure 40 B, Figure 40 C, the blank parts of guiding catheter 7 tube wall represents the part that structural pipe wall hardness lowers, for the mode of the material hardness by changing guiding catheter 7 segment, only need the softer material of the blank parts of guiding catheter 7 tube wall in Figure 40 B, Figure 40 C to manufacture.As shown in Figure 40 B, Figure 40 C, guiding catheter 7 can adopt chicken ribs spline structure, and preferably adopts the design of the chicken ribs spline structure shown in Figure 32; As shown in Figure 40 B, when needs reinforcement guiding catheter 7 bends to direction shown in arrow ao1, the project organization strengthening tube wall hardness in guiding catheter 7 tube wall of arrow ao1 side can be weakened, such as can keep at a certain distance away and the tinsel in guiding catheter 7 tube wall of arrow ao1 side removed, when increasing the tension force of guide wire 70, guiding catheter 7 will easilier bend to arrow ao1 direction; As shown in figure 40 c, for the situation of line traffic control compound bending, the project organization can strengthening tube wall hardness in the tube wall of guiding catheter 7 both sides weakens, and such as, can keep at a certain distance away and to be removed by the tinsel in arrow ao2 and arrow ao3 side guiding catheter 7 tube wall; The chicken ribs spline structure bent for multidirectional control can the design of reference diagram 32D.In addition, guiding catheter 7 head also first can make the bending shape to certain direction, like this when ACTIVE CONTROL deformation and Passive Control deformation can not occur guiding catheter 7, also guiding catheter 7 can be helped to arrive renal artery, if ACTIVE CONTROL deformation and Passive Control deformation can be there is in guiding catheter 7, the preformed curvature state of guiding catheter 7 can also increase the control bending direction of guiding catheter 7, such as the ACTIVE CONTROL deformation of guiding catheter 7 and the bending direction of Passive Control deformation are arranged to contrary with preset deformation bending direction, this makes it possible to control the bending of both direction.The traveling path of guide wire 70 in guiding catheter 7 tube wall is determined according to the deformation form of guiding catheter 7, general parallel with the guiding catheter 7 major axis neutral conductor; Guide wire 70 can be connected to guiding catheter 7 tail end independently on guiding catheter control handle 27, this guiding catheter control handle 27 can be connected with joystick 2 or independently exist, guide wire 70 in guiding catheter 7 also can be directly connected to joystick 2, is controlled (aftermentioned) by joystick 2.Magnetron configuration for guiding catheter 7 designs, preferably by permanent magnet, electric magnet or other can be arranged in the tube wall of guiding catheter 7 head and neighbouring position thereof by the material of attraction, the bending of guiding catheter 7 multiple directions can be controlled by the change in externally-applied magnetic field direction.Also the deformation of design more easily can be realized by the hardness distribution of the hardness and then change guiding catheter 7 that adjust the structural design of guiding catheter 7 and the manufactured materials of guiding catheter 7 segment for adopting the guiding catheter 7 of magnetron configuration design.Certain technical staff can according to actual needs, adjustment permanent magnet, electric magnet or other can, by the setting position of the material of attraction on guiding catheter 7, make guiding catheter 7 form the deformation of other shapes.

Described ablation catheter 1 and guiding catheter 7 outer surface can labelling development scales, to indicate the length, width etc. of the degree of depth of ablation catheter 1 and guiding catheter 7 intravasation and convenient indirect inspection organization of human body under the image documentation equipments such as ultrasonic, X-ray.Ablation catheter 1 and guiding catheter 7 also can be arranged different developing marks for distinguishing different conduits under the image documentation equipments such as ultrasonic, X-ray.Each absolute construction 8 is preferably arranged different developing marks for distinguishing different absolute construction 8 under the image documentation equipments such as ultrasonic, X-ray, such as at an absolute construction 8 subscript triangle, and square marked in another absolute construction 8, or at absolute construction 8 subscript three band, and two bands marked in another absolute construction 8.In addition ablation catheter 1 and guiding catheter 7 also can be arranged developing mark for distinguishing different axial-rotation states under the image documentation equipments such as ultrasonic, X-ray, such as a short-term that can develop under the image documentation equipments such as ultrasonic, X-ray is set at the left surface of ablation catheter 1, at the right flank of ablation catheter 1, another short-term that can develop under the image documentation equipments such as ultrasonic, X-ray is set, when ablation catheter 1 is horizontal, two short-terms overlap, when ablation catheter 1 axial-rotation certain angle, short-term is then separated by a distance.The probability of damage is caused in order to reduce ablation catheter 1 and guiding catheter 7 pairs of blood vessels, preferably, ablation catheter 1 and guiding catheter 7 preferably as far as possible smooth with the place of vessel wall contact, simultaneously form preferably try one's best round and smooth, the head of ablation catheter 1 and guiding catheter 7 is preferably softer in addition.

Directly or indirectly all may must reach corresponding with human body fluid or the national standard of tissue contacting material in ablation catheter 1 and guiding catheter 7 to the part of human body fluid or contact tissue, again may directly or indirectly and the ablation catheter 1 of human body fluid or contact tissue and the part of guiding catheter 7 for above-mentioned requirements can not be reached, must wrap up with the material of the national standard meeting the material that to contact with human body fluid or tissue outside it.Ablation catheter 1 and guiding catheter 7 may should be able to tolerate at least one medical disinfecting method with the manufactured materials of the direct or indirect contact portion of human body.The part that ablation catheter 1 and guiding catheter 7 directly or indirectly may contact with human body should be insulate, can outer wrapping insulant for the place that can not reach insulating requirements.

Above-mentioned controllable bending tune 5 act on catheter body section 4 when controllable bending tune 5 is not set, can, by catheter body section 4 on behalf of enforcement, only need the design of above-mentioned controllable bending tune 5 to apply to catheter body section 4.

Technical staff can be merged, improve and cross-reference according to the design of actual requirement to these ablation catheters 1 above-mentioned and guiding catheter 7, and these equivalence changes and modification fall into the scope of the claims in the present invention equally.

Be connected to joystick 2 by the responsible situation about controlling of joystick 2 for guiding catheter 7, joystick 2 can control guiding catheter 7 and ablation catheter 1 simultaneously.Can controlled bending direction quantity and can controlled bend mode according to guiding catheter 7, the design of joystick 2 is slightly different.Control owing to generally adopting the deformation of line traffic control structure to guiding catheter 7, therefore the design of joystick 2 is based on line traffic control structure, for other control modes of guiding catheter 7 deformation, only need the basis of online control structure joystick 2 is improved a little.Figure 41, Figure 42, Figure 43 are all for line traffic control structure, show the main structure of joystick 2.In Figure 41 A, Figure 41 C, design illustrated in Figure 42, guiding catheter 7 is connected with joystick 2 is stable, is responsible for control by joystick 2; In the design that Figure 41 B illustrates, guiding catheter 7 is connected with ablation catheter 1 afterbody by the jointing 71 of end, and when needs, guiding catheter 7 can be separated with ablation catheter 1 end again; In design illustrated in Figure 43, guiding catheter 7 is connected with guiding catheter control handle 27, is responsible for control by guiding catheter control handle 27.In Figure 41, Figure 42, Figure 43, dotted line ac represents wire, fine duct, the optical fiber in joystick 2.

When Figure 41 to show in embodiments of the invention not by ACTIVE CONTROL deformation or Passive Control shape control guiding catheter 7 bending direction, the main structure of joystick 2.Figure 41 A, Figure 41 C show guiding catheter 7 with in the stable situation that is connected of joystick 2, the main structure of joystick 2, Figure 41 B shows guiding catheter 7 when being connected with ablation catheter 1 afterbody by the jointing 71 of end, the main structure of joystick 2, wherein Figure 41 C is the schematic cross-section that in Figure 41 A, dotted line cc cross section amplifies.As shown in Figure 41 A, joystick 2 is preferably designed to diagram shape, form primarily of lever 271 and lever 241, wherein lever 271 is generally positioned at the front portion of joystick 2, primary responsibility controls guiding catheter 7, and lever 241 is generally positioned at the rear portion of joystick 2, primary responsibility controls ablation catheter 1; Lever 271 is connected with guiding catheter 7 end, the groove tooth slide construction that lever 271 is indicated by dotted rectangle ar in figure with lever 241 is connected, groove tooth slide construction is mutually coincide by the annular hook formation 272 of lever 271 afterbody and the annular hook formation 240 of lever 241 head and forms, and can relatively rotate after connecting.As shown in Figure 41 A, Figure 41 C, the connecting rod 251 that ablation catheter 1 and cross section radial launch is connected, connecting rod 251 is connected with annular control knob 250, propelling movement (as Figure 41 B shows) or rollback annular control knob 250 can realize advance or the rollback of ablation catheter 1, due to control knob 250 circlewise, even if therefore rotation process handle 241 does not still affect and controls ablation catheter 1 by annular control knob 250.Figure 41 C shows the schematic cross-section that Figure 41 A dotted line cc cross section amplifies, and contributes to the space structure relation further illustrating connecting rod 251, annular control knob 250, lever 241.As shown in fig. 41c, the connecting rod 251 that ablation catheter 1 and cross section radial launch is connected, connecting rod 251 is through the one section of gathering sill 244 on lever 241 and annular control knob 250, because gathering sill 244 can limit the rotation of connecting rod 251, any one of therefore rotating annular control knob 250 and lever 241 can realize rotating together with both, and then realizes the rotation of ablation catheter 1; The length of certain gathering sill 244 is ablation catheter 1 can the distance of movement, this length is generally less than the width of annular control knob 250, so annular control knob 250 can cover gathering sill 244, is also unlikely to the internal structure appearing joystick 2 when annular control knob 250 slides; The quantity of connecting rod 251 and gathering sill 244 differs and is decided to be four, can adjust according to actual needs.As shown in Figure 41 A, energy exchange joint 201 is preferably provided with at the afterbody of lever 241, energy exchange joint 201 (includes wire by cable 23, optical fiber or fine duct etc., Fig. 1 shows) with melt generating means part 3 and be connected, primary responsibility receives by melting energy that generating means 3 transmits and by this energy by the wire in joystick 2, fine duct, optical fiber ac etc. transfers to and melts 9, the part that on ablation catheter 1, other need energy to supply, guiding catheter 7 needs the part that the part of energy supply and joystick 2 need energy to supply, energy exchange joint 201 is also with transmission ablation catheter 1 simultaneously, sensor signal on guiding catheter 7 and joystick 2 and reception are melted instruction that generating means 3 transmits and are passed to ablation catheter 1, the effect of guiding catheter 7 and joystick 2.As shown in Figure 41 A, the position of the end of lever 241 and energy exchange joint 201 vicinity according to circumstances can arrange pouring liquid joint 202, pouring liquid joint 202 is connected with the fine duct in ablation catheter 1, for providing liquid coolant to ablation catheter 1, contrast agent etc., pouring liquid joint 202 is connected with pouring liquid device 203 by conduit outside joystick 2, this pouring liquid device 203 can be arranged on and melt in generating means part 3, by the control of melting generating means part 3, also can be the system independent of melting generating means part 3, this pouring liquid device 203 can be manually carry out pouring liquid simultaneously, also can be automatically carry out pouring liquid.The outer surface of this external lever 241 and the signable ablation catheter 1 of the outer surface of annular control knob 250 push distance and push direction, in the outer surface of annular hook formation 272 and the signable lever 271 of the outer surface of lever 241 and lever 241 relative rotation angle and direction of rotation.As shown in figure 41b, whole joystick 2 forms primarily of lever 217, guiding catheter 7 will not be connected with joystick 2, ablation catheter 1 end is connected with the head end of lever 217, rigidized cover 48 is provided with at the near-end of ablation catheter 1, the place not easily deformation be connected with joystick 2 to make ablation catheter 1, convenient operation.As shown in figure 41b, guiding catheter 7 is connected with ablation catheter 1 afterbody by the jointing 71 of end, the rigidized cover 48 of ablation catheter 1 afterbody contributes to ablation catheter 1 and is connected with jointing 71, and the sealing ring in guiding catheter 7 or sealing shroud 79 can spill and prevent to spill to the medicine of intravascular injection or the contrast agent of injection through guiding catheter 7 through guiding catheter 7 by anti-Hemostatic Oral Liquid; Will mainly through front sending or rollback operation handle 217 and rotation process handle 217 to the control of ablation catheter 1.As shown in figure 41b, similarly, be preferably provided with energy exchange joint 201 at the afterbody of lever 217, according to circumstances the side of energy exchange joint 201 can arrange pouring liquid joint 202.

Figure 42 is for line traffic control structure, and showing in embodiments of the invention can by the main structure of the joystick 2 of ACTIVE CONTROL or Passive Control shape control guiding catheter 7 bending direction; Wherein Figure 42 A, Figure 42 B show joystick 2 can control guiding catheter 7 bend situation to a direction under the main structure of joystick 2, Figure 42 C, Figure 42 D show joystick 2 can control guiding catheter 7 bend situation to both direction under the main structure of joystick 2, Figure 42 E, Figure 42 F are for the situation of four guide wires 70, show joystick 2 and can control the main structure of guiding catheter 7 to joystick 2 in the bending situation of multiple directions (>=3 direction); Because the design of lever in Figure 42 241 is identical with the design of lever 241 in Figure 41 A, Figure 41 C, therefore Figure 42 mainly shows the construction features of lever 271, just no longer repeats here in addition for the place that the design of joystick 2 illustrated in Figure 42 is identical with the design of joystick 2 illustrated in Figure 41.Figure 42 A, Figure 42 B show joystick 2 and can control under guiding catheter 7 bends situation to a direction, and the main structure of joystick 2, now preferably arranges a guide wire 70; Wherein Figure 42 B is the schematic cross-section that in Figure 42 A, dotted line cc1 cross section amplifies.As shown in Figure 42 A, after guide wire 70 goes out from the traveling of guiding catheter 7 end, the interface channel 277 on lever 271 is connected with the control knob 237 of similar annular on encircling operation handle 271, and control knob 237 can slide on lever 271; When pushing control knob 237 to arrow ao1 direction, guide wire 70 will be subject to tractive, can control the bending direction of guiding catheter 7 in this way.The bending of guiding catheter 7 is caused to injure blood vessel wall in order to avoid guide wire 70 is subject to undue tractive, can buffer structure be set, one section, the centre by the guide wire 70 of traveling in interface channel 277 replaces with spring or tool fine rule springy, Figure 42 A is described to arrange spring 282, slightly thick to hold spring 282 at interface channel 277 diameter at spring 282 place, when tractive guide wire 70, spring 282 can stretch, the effect of buffering traction force can be played like this, simultaneously because the diameter of spring 282 is slightly larger than the diameter of both sides interface channel 277, therefore the extension distance of spring 282 can not exceed the part that interface channel 277 expands, this just makes spring 282 be unlikely to exceed spring 282 maximum extension apart from lower produced pulling force to the tension force of the guide wire 70 of guiding catheter 7 head end, also be just equivalent to set a pulling force limit value.Certainly cause the bending of guiding catheter 7 to injure blood vessel wall in order to avoid guide wire 70 is subject to undue tractive, tension pick-up can also be connected on guide wire 70.In addition, technical staff can also according to actual needs by regulating the initial tension of guide wire 70, the traveling path of guide wire 70 in joystick 2, interface channel 277 to regulate and control in the mode such as openings of sizes of lever 271 female the sensitivity that control knob 237 controls guide wire 70.In order to the rotation of the rotation control operation handle 271 by control knob 237, can groove tooth slide construction be set between control knob 237 and lever 271; As shown in Figure 42 B, the little rectangle frame rc of dotted line is the position at groove tooth slide construction place, image in dotted line large rectangle frame shows the enlarged drawing of groove tooth slide construction, groove tooth slide construction is made up of groove 285 and projecting teeth 286, Figure 42 B is arranged at respectively on control knob 237 and lever 271 for groove 285 and projecting teeth 286 and is described, and also can be arranged on lever 271 and control knob 237 respectively by groove 285 and projecting teeth 286 as the case may be; When rotating control knob 237, due to the existence of groove tooth slide construction, rotated together by drive lever 271, control knob 237 slide anteroposterior can not be affected again simultaneously; Technical staff can the position of adjustment tank tooth slide construction and magnitude setting as required, if ensure control knob 237 and lever 271 can together with to rotate and the slide anteroposterior of control knob 237 is unaffected.For convenience of operation, at outer surface signable control knob 237 displacement and the moving direction of lever 271 and control knob 237, in the signable lever 271 of outer surface of the outer surface of lever 241, the outer surface of annular hook formation 272 and control knob 237 and lever 241 relative rotation angle and rotation direction.Figure 42 C, Figure 42 D show joystick 2 and can control under guiding catheter 7 bends situation to both direction, and the main structure of joystick 2, wherein Figure 42 D is the schematic cross-section that in Figure 42 C, dotted line cc2 cross section amplifies.As shown in Figure 42 C, two guide wires 70a, 70b are now preferably set, two guide wires 70a, 70b bending each control guiding catheter 7 one directions, and be preferably connected with control knob 237 on relative position respectively through interface channel 277a, 277b, the tractive of spring 282 for dash-control button 237 pairs of guide wires 70 similarly also can be set; Control knob 237 can slide anteroposterior, and when control knob 237 slides to arrow ao2 direction, guide wire 70b will be subject to tractive, and spring 282b stretches, and guide wire 70a is due to the existence of interface channel 277a far-end funnel-like groove 278a, and it is in relaxation state; When control knob 237 slides to arrow ao3 direction, guide wire 70a will be subject to tractive, and spring 282a stretches, and guide wire 70b is due to the existence of interface channel 277b far-end funnel-like groove 278b, and it is in relaxation state.Similarly, technical staff can regulate and control by modes such as the position regulating the initial tension of guide wire 70, the traveling path of guide wire 70 in joystick 2, control knob 237 charge into lever 271 part, funnel-like groove 278 openings of sizes and setting positions the sensitivity that control knob 237 controls two guide wires 70 according to actual needs, and when making control knob 237 leave initial position same distance in different directions, two guide wires 70 are subject to the tractive of identical or different size power.Similarly, in order to realize the rotation of the rotation control operation handle 271 by control knob 237, what the design shown in Figure 42 C, Figure 42 D also can adopt Figure 42 B to illustrate arranges groove tooth slide construction between control knob 237 and lever 271.If guiding catheter 7 has the preformed curvature deformation in a direction, and guide wire 70 is arranged on another one direction with the deformation of antagonism preformed curvature and realizes controlling the bending of guiding catheter 7 two relative directions, need in this case to remove one from guide wire 70a, 70b, and remove corresponding accessory structure.Similarly, at outer surface signable control knob 237 displacement and the moving direction of lever 271 and control knob 237, in the signable lever 271 of outer surface of the outer surface of lever 241, the outer surface of annular hook formation 272 and control knob 237 and lever 241 relative rotation angle and rotation direction.Figure 42 E, Figure 42 F are for the situation of four guide wires 70, show joystick 2 and can control the main structure of guiding catheter 7 to joystick 2 in the bending situation of multiple directions (>=3 direction), wherein Figure 42 F is the schematic cross-section that in Figure 42 E, dotted line cc3 cross section amplifies.As shown in Figure 42 E, the control knob 237 controlling guide wire 70 in Figure 42 A, Figure 42 B, Figure 42 C, Figure 42 D is replaced by console panel 238, console panel 238 does not charge into the part of lever 271, and the contact surface between lever 271 and console panel 238 is the part in spherical universal joint, therefore console panel 238 can rotate to multiple directions, and promotion console panel 238 can not move it and skid off lever 271 forward or backward.Cause chart 42E due to cross section only show two guide wires 70a, 70c.As shown in Figure 42 E, Figure 42 F, four guide wires 70a, 70b, 70c, 70d that each control controllable bending tune 5 one directions bend will be connected with console panel 238 respectively through interface channel 277a, 277b, 277c, 277d, four guide wires 70 are preferably uniformly distributed in console panel 238 and lever 271 circumferentially, similarly also can buffer structure be set, such as, the tractive of spring 282 for dash-control dish 238 pairs of guide wires 70 is set; When console panel 238 rotates to direction shown in arrow ao4, guide wire 70c will be subject to tractive, and spring 282c stretches, and guide wire 70b is due to the existence of interface channel 277b far-end funnel-like groove 278b, and it is in relaxation state; When console panel 238 rotates to direction shown in arrow ao5, guide wire 70a will be subject to tractive, and spring 282a stretches, and guide wire 70c is due to the existence of interface channel 277c far-end funnel-like groove 278c, and it is in relaxation state; If console panel 238 rotation direction is not on any guide wire 70, now will two adjacent guide wires 70 be had to be subject to tractive, the direction that the guide wire 70 being subject to tractive to two is made a concerted effort bends by such guiding catheter 7, is namely achieved the multi-direction bending controlling guiding catheter 7 by such mode.Similarly, technical staff can also according to actual needs by regulating the modes such as the initial tension of guide wire 70, the traveling path of guide wire 70 in joystick 2, funnel-like groove 278 openings of sizes and setting position to regulate and control the sensitivity that console panel 238 controls four guide wires 70, and when making console panel 238 leave initial position same distance on four guide wire 70 directions, four guide wires 70 are subject to the tractive of identical or different size power.Similarly, in outer surface signable console panel 238 rotational angle and the rotation direction of lever 271 and console panel 238, in the signable lever 271 of outer surface of the outer surface of lever 241, the outer surface of annular hook formation 272 and console panel 238 and lever 241 relative rotation angle and rotation direction.Figure 42 E, Figure 42 F only carry out structure explanation for four guide wires 70, and the design shown in Figure 42 E, Figure 42 F can also be used for expanding the situation being more than or equal to for guide wire 70.For the situation by the deformation of magnetron configuration design con-trol guiding catheter 7, removing corresponding line traffic control structure in the design of joystick 2 illustrated in Figure 42, control knob 237 and console panel 238 being changed into the Passive Control deformation of the magnetron configuration design for controlling guiding catheter 7; For the situation by the deformation of ACTIVE CONTROL shape control guiding catheter 7, removing the line traffic control structure in Figure 42, control knob 237 and console panel 238 being changed into the ACTIVE CONTROL deformation for controlling guiding catheter 7.

Guiding catheter 7 also can directly be connected with guiding catheter control handle 27, control is responsible for by guiding catheter control handle 27, now preferably guiding catheter control handle 27 can engage with the joystick 2 controlling ablation catheter 1 and break, design illustrated in Figure 43 is with Figure 41, carry out based on design illustrated in Figure 42 improving, the design improved mainly is improved lever 241, therefore in the design of guiding catheter control handle 27 illustrated in Figure 43 and joystick 2 with Figure 41, the place that design illustrated in Figure 42 is consistent just repeats no more here.Figure 43 is the design that can control guiding catheter control handle 27 when guiding catheter 7 bends to a direction and joystick 2 for guiding catheter control handle 27, describe the present invention how to realize independently guiding catheter control handle 27 and joystick 2 to be bonded with each other and to break, namely realize both separable uses and also can engage use; Wherein Figure 43 B is the schematic diagram of guiding catheter control handle 27, and Figure 43 C is the schematic diagram of joystick 2, and Figure 43 A is the schematic diagram that both are bonded together, and Figure 43 D, Figure 43 E are the schematic cross-section that in Figure 43 A, dotted line cc1, cc2 cross section amplifies respectively.As shown in Figure 43 B, guiding catheter control handle 27 forms primarily of lever 271', lever 273, control knob 237', and the rotation between lever 271' and lever 273 lever can by being realized by annular hook formation 272 and the mutual groove tooth slide construction formed that coincide of annular hook formation 270 shown in dotted rectangle ar in figure.As shown in Figure 43 C, joystick 2 forms primarily of lever 241, annular control knob 250, connecting rod 251, energy exchange joint 201, the scheme mentioned in the implementation of rotating together of lever 241 and annular control knob 250 and Figure 41 is identical, according to circumstances arranges or does not arrange pouring liquid joint 202.When guiding catheter control handle 27 needs to engage with joystick 2, first ablation catheter 1 will be inserted in guiding catheter 7 through guiding catheter control handle 27, as shown in Figure 43 A, Figure 43 B, Figure 43 C, guiding catheter control handle 27 and the joint of joystick 2 become a control handle and mainly rely on taken off groove tooth slide construction on lever 273 and lever 241, and this can take off groove tooth slide construction and be given prominence to tenon 243 formed by the pressed hook formation 242 on the draw-in groove 293 on lever 273, cone column recesses 292, snap ring 297, hole clipping 299 and lever 241, cone cylinder.As Figure 43 A, shown in Figure 43 B, during joint, hook formation 242 pairs of draw-in grooves 293 can be pressed, cone cylinder is given prominence to tenon 243 and aim at cone column recesses 292, then push operation handle 241 or back pressure guiding catheter control handle 27, because the inclined-plane that the pressure of hook formation 242 head can be pressed to turn round 294 leans on the inclined-plane of lever 241 relative with snap ring 297, hook formation 242 can be pressed to take advantage of a situation and to enter draw-in groove 293, cone cylinder gives prominence to tenon 243 also will enter cone column recesses 292, when lever 273 and lever 241 are close to when contacting, hook formation 242 can be pressed to spring in the hole clipping 299 that is made up of snap ring 297 and lever 273, due to the restriction that the pressure of hook formation 242 head can be pressed to turn round 294 and hole clipping 299, guiding catheter control handle 27 will be very stable with the joint of joystick 2.As Figure 43 A, shown in Figure 43 B, during separation, the pressure of hook formation 242 head can be pressed to turn round 294 for two simultaneously on pressing relative position makes it exit in hole clipping 299, take advantage of a situation simultaneously and push guiding catheter control handle 27 or pullback operation handle 241, due to snap ring 297 inclined-plane with can press the pressure of hook formation 242 head turn round 294 inclined-plane relative, pressure is turned round 294 and will again be entered draw-in groove 293, along with lever 273 and lever 241 further away from each other, the head pressure of hook formation 242 can be pressed to turn round 294 and will eject draw-in groove 293, cone cylinder is given prominence to tenon 243 and also will be exited cone column recesses 292 simultaneously, ablation catheter 1 exits guiding catheter 7 subsequently, complete separation.In order to make to press hook formation 242 can pass in and out smoothly draw-in groove 293 simultaneously draw-in groove 293 can limit again the rotation can pressing hook formation 242, as shown in Figure 43 D, the width of draw-in groove 293 preferably with hook formation 242 can be pressed close, and can just block and can press hook formation 242, and the height of draw-in groove 293 is preferably greater than the thickness of press button 294.In addition, in order to realize lever 273 rotation together with lever 241, as shown in Figure 43 D, Figure 43 E, can give prominence at cone cylinder groove tooth slide construction dotted rectangle rc in similar Figure 42 being set between tenon 243 and lever 273 and illustrating; This structure is exaggerated in dotted line large rectangle in Figure 43 E, wherein preferred groove 295 is arranged on lever 273, projecting teeth 296 being arranged on cone cylinder gives prominence on tenon 243, groove 295 also can be arranged on cone cylinder and give prominence on tenon 243 by technical staff as required, is arranged on by projecting teeth 296 on lever 273; Have four groove tooth slide constructions in Figure 43 D, Figure 43 E, technical staff can adjust its quantity and branch as required.In addition, hook formation 242 can be pressed preferably to be set to two, and technical staff can adjust as required.Similarly, for convenience of operation guiding catheter control handle 27, can on control knob 237', lever 271' indicates displacement and the moving direction of control knob 237', on control knob 237', on lever 271', on lever 273, indicate lever 271' and lever 273 relative rotation angle and direction of rotation; Conveniently guiding catheter control handle 27 engages with joystick 2, the pairs of bit line, alignment mark etc. that engage both can indicating respectively with on joystick 2 on guiding catheter control handle 27.For the situation by the deformation of magnetron configuration design con-trol guiding catheter 7, removing corresponding line traffic control structure in the design of guiding catheter control handle 27 illustrated in Figure 43, control knob 237' being changed into the Passive Control deformation of the magnetron configuration design for controlling guiding catheter 7; For the situation by the deformation of ACTIVE CONTROL shape control guiding catheter 7, removing the line traffic control structure in Figure 43, control knob 237' being changed into the ACTIVE CONTROL deformation for controlling guiding catheter 7.Figure 43 is only that the guiding catheter control handle 27 that can control when guiding catheter 7 bends to a direction for guiding catheter control handle 27 is described with the design of joystick 2, can the bending situation of two-way or multidirectional control for guiding catheter 7, only needing the lever 271' in Figure 43 to replace to guiding catheter 7 can the lever 271 of two-way or multidirectional control when bending or lever 213.In addition can take off Fastening tenon structure and mentality of designing also easily extensible in other designs of joystick 2 and the design of other controllers.

If when guiding catheter control handle 27 to become one joystick 2 with joystick 2 Combined design, need to guide guiding catheter 7 intravasation with seal wire, the head end opening of preferred not confined bed guiding tube 7, by seal wire being passed inclined hole 74 or side channel 76 i.e. bootable guiding catheter 7 intravasation of guiding catheter 7 head end opening and guiding catheter 7 head, for the situation not arranging inclined hole 74 or side channel 76 of guiding catheter 7 head, the inclined hole 74 that similar Figure 26 B illustrates can be set in the head side wall of guiding catheter 7, by seal wire being passed inclined hole 74 i.e. bootable guiding catheter 7 intravasation in guiding catheter 7 head end opening and head side wall.

In the design of these joysticks 2 above-mentioned and guiding catheter control handle 27, the appearance curve of joystick 2 and guiding catheter control handle 27 preferably facilitates holding of staff and controls.Directly or indirectly all may must reach corresponding with human body fluid or the national standard of tissue contacting material in joystick 2 and guiding catheter control handle 27 to the part of human body fluid or contact tissue, again may directly or indirectly and the joystick 2 of human body fluid or contact tissue and the part of guiding catheter control handle 27 for above-mentioned requirements can not be reached, must wrap up with the material of the national standard meeting the material that to contact with human body fluid or tissue outside it.Joystick 2 and guiding catheter control handle 27 may should be able to tolerate at least one medical disinfecting method with the manufactured materials of the direct or indirect contact portion of human body.The part that joystick 2 and guiding catheter control handle 27 directly or indirectly may contact with human body should be insulate, can outer wrapping insulant for the place that can not reach insulating requirements.

Technical staff can be merged, improve and cross-reference according to the design of actual requirement to these joysticks 2 above-mentioned and guiding catheter control handle 27, and these equivalence changes and modification fall into the scope of the claims in the present invention equally.

As shown in Figure 1, melting generating means 3 is for ablation catheter 1, guiding catheter 7, joystick 2, guiding catheter control handle 27 need the part of energy supply to provide the energy of corresponding form, such as when guiding catheter 7 needs intellectual material to change shape, melting generating means 3 can provide the energy of induction intellectual material change required for shape.Melt the information that generating means 3 could receive and process ablation catheter 1, guiding catheter 7, joystick 2, guiding catheter control handle 27 transmit simultaneously, information after process partly or entirely can be presented at and melt on the display 320 of generating means 3, and information after this process feedback regulation can also melt the energy output of generating means 3.Ablation generator comprises radio-frequency (RF) ablation generator, resistance heated generator, cryoablation generator, supersonic melting generator, laser ablation generator, optical dynamic therapy generator or microwave ablation generator, describedly melting the one that generating means 3 can be above generator, also can be the combination of two or more generators above.The controling parameters melting generating means 3 can be carried out touch screen control by the display 320 melting generating means or be regulated by parameter set button 330; Melting generating means 3 and should be provided with the joint of energy output and the joint 311 of sensor signal input, also should being provided with the joint 321 connected with external power supply, for receiving the electric energy transmitted by power supply circuits simultaneously.Energy supply needed for ablation catheter 1, joystick 2, guiding catheter 7 and guiding catheter control handle 27 and on joystick 2 or guiding catheter control handle 27, is not provided with the equipment of operating switch, being preferably provided with operating switch melting on generating means 3.For ablation catheter 1 or/and guiding catheter 7 need coolant, rewarming agent and infusion liquid situation, melt generating means 3 or/and guiding catheter 7 can be provided with filling apparatus carries out automatic or manual and pour into coolant, rewarming agent and infusion liquid to ablation catheter 1, now melt generating means 3 should have corresponding pipeline and coolant is provided, the container of rewarming agent and infusion liquid raw material or finished product communicates.The priming device connected for the distal aperture 77 of guiding catheter 7 is arranged on the situation melting generating means 3, melts generating means 3 and tackles this priming device and carry out controlling and arrange corresponding control panel or control knob.Melting generating means 3 can be merge above-mentioned functions in the complete machine of one, and also can be the split air conditioner of exercising difference in functionality respectively, such as, by being independently an extension set for melting a part of 9 energy supplies, be independently another extension set by filling apparatus.

Claims

1. kidney goes a sympathetic nerve ablation catheter system, it is characterized in that comprising:

Ablation catheter (1), guiding catheter (7), joystick (2) and melt generating means (3), wherein ablation catheter (1) comprises catheter body section (4) and the section of melting (6) from lower to upper successively; Wherein

Described catheter body section (4) is connected with joystick (2);

The described section of melting (6) comprises at least two absolute construction (8), each absolute construction (8) divides circle equally on cross section, the near-end of described absolute construction (8) is connected, described in the section of melting (6) have at least an absolute construction (8) is provided with and melt head (9); The described head (9) that melts is connected with the energy exchange joint (201) on joystick (2) by wire, conduit, microwave antenna or optical fiber, described energy exchange joint (201) by wire, conduit, microwave antenna or optical fiber with melt generating means (3) and be connected;

The control of above absolute construction (8) also comprises absolute construction and arranges (8) prefabricated deformation; Evenly continue before and after between described catheter body section and the section of melting, namely the outline of the section of melting (6) cross section that surrounds of the outline of absolute construction (8) cross section is close to the outline of controllable bending tune (5) cross section; Be connected at near-end between described absolute construction (8), between two absolute construction (8), comprise four kinds of forms: the far-end of two absolute construction (8) connects as one and forms and melt paragraph header end (17); Or two absolute construction (8) far-ends are separated from each other independently of one another; Or the mid portion of two absolute construction (8) links together, and far-end is separated from each other again;

Described guiding catheter (7) is attached on guiding catheter (7) head end by tractive or propelling movement one end, and the guide wire (70) that the other end is controlled by handle controls bending; Or described guiding catheter (7) is containing can, by the material of attraction, make guiding catheter (7) that deformation occur by externally-applied magnetic field; Or by controlling the intellectual material of guiding catheter (7) upper energy perception outside stimulus; Or described guiding catheter (7) generation compliance is bending or/and arrange prefabricated deformation;

Described guiding catheter (7) is controlled by guiding catheter control handle (27) or joystick (2) and is not controlled by handle.

2. kidney according to claim 1 goes sympathetic nerve ablation catheter system, it is characterized in that: the far-end of described catheter body section (4) is the controllable bending tune (5) that is connected of the section of comprising and melt (6) near-end also, and it is bending or/and arrange prefabricated deformation that compliance occurs described controllable bending tune (5); Described guiding catheter (7) also comprises independent setting or not only erects the guiding catheter control handle (27) put.

3. kidney according to claim 1 goes sympathetic nerve ablation catheter system, it is characterized in that: described ablation catheter (1) is or/and joystick (2) is or/and guiding catheter (7) is also provided with sensor (192).

4. kidney according to claim 2 goes sympathetic nerve ablation catheter system, it is characterized in that: described guiding catheter control handle (27) is also provided with sensor (192).

5. kidney according to claim 1 goes sympathetic nerve ablation catheter system, it is characterized in that: when guiding catheter (7) provides fulcrum for ablation catheter (1) deformation, the head of guiding catheter (7) arranges the inclined hole (74) that communicates with blood vessel or/and side channel (76).

6. kidney goes sympathetic nerve ablation catheter system according to claim 1 or 5, it is characterized in that: when the far-end of absolute construction (8) connect as one and form melt paragraph header end (17) time, guiding catheter head end arranges throat structure (73) or plug (72), the head side wall of guiding catheter (7) is arranged side channel (76); When absolute construction (8) is separated from each other independently of one another, the head end of guiding catheter (7) or head side wall arrange inclined hole (74); When the mid portion of absolute construction (8) links together, when far-end is separated from each other again, the head end of guiding catheter (7) or head side wall arrange the inclined hole (74) communicated with blood vessel, after inclined hole (74) guiding catheter (7) sidewall on side channel (76) is set again.

7. kidney according to claim 1 goes sympathetic nerve ablation catheter system, it is characterized in that: when guiding catheter (7) does not provide fulcrum for ablation catheter (1) deformation, absolute construction (8) arranges prefabricated deformation.

8. kidney according to claim 1 goes sympathetic nerve ablation catheter system, it is characterized in that: also comprise controllable bending tune (5) and arrange prefabricated deformation.

9. kidney according to claim 1 goes sympathetic nerve ablation catheter system, it is characterized in that: described in melt that head (9) is selected from radio-frequency ablation electrode head, resistance heated melts head, liquid cooling perfusion radio frequency electrical cartridge, cryoablation head, supersonic melting probe, focused ultrasound ablation probe, laser ablation head, laser focusing melt head, optical dynamic therapy melts head or microwave ablation head; Wherein

Described radio-frequency ablation electrode head comprises radio-frequency ablation electrode (91);

Described liquid cooling perfusion radio frequency electrical cartridge comprises radio-frequency ablation electrode (91), the surface of radio-frequency ablation electrode or near be provided with aperture (193), described aperture (193) is connected with the conduit (103) in separate component or separate chamber (69), described conduit (103) or separate chamber (69) are communicated with the pouring liquid joint (202) on joystick (2) by conduit (103), inject cooling liquid by pouring liquid joint (202);

Described cryoablation head comprises the coolant conducting surface (94) be positioned on absolute construction (8), coolant chamber (61), the J-T nozzle (190) being positioned at coolant chamber (61) coolant inlet side and refrigerant recovering conduit (64), and around described coolant conducting surface, tube wall contains adiabator; By input pipe (194), liquid or gas are transported to by J-T nozzle (190) the coolant chamber (61) be arranged on absolute construction (8);

Described laser ablation head or optical dynamic therapy melt head and include optical fiber (95), are positioned at aperture (193) near optical fiber head, also comprise the separate chamber (69) be communicated with aperture (193); Described laser focusing melts the lens spline structure (195) arranged before head also comprises the head being positioned at optical fiber (95);

Described microwave ablation head comprises the microwave ablation contact (93) be arranged on absolute construction, and described microwave ablation contact (93) is connected with microwave antenna; The surrounding of described microwave ablation contact (93) arranges insulating barrier (87), and microwave ablation contact (93) is also provided with coolant around and derives aperture (193);

The surrounding of described supersonic melting probe or focused ultrasound ablation probe arranges the conduit (103) for carrying cooling liquid.

10. kidney according to claim 1 goes sympathetic nerve ablation catheter system, it is characterized in that: the afterbody sidewall of described guiding catheter (7) is also provided with the perforate (77) carrying out Ink vessel transfusing injection or injection Intravascular contrast agents for connecting syringe or priming device, or by guiding catheter (7) distal opening with syringe or/and priming device is connected carry out Ink vessel transfusing injection or/and inject Intravascular contrast agents; Or/and described guiding catheter (7) end arranges jointing (76), jointing (76) is connected with syringe, priming device, ablation catheter (1) or joystick (2).

11. kidneys according to claim 1 go sympathetic nerve ablation catheter system, it is characterized in that: described ablation catheter (1) or/and by selecting the material of different hardness when guiding catheter (7) manufactures, or passes through optionally to reduce or/and increase the internal structure of catheter segment or/and the structure of tube wall.

12. kidneys according to claim 1 go sympathetic nerve ablation catheter system, it is characterized in that: described ablation catheter (1) or/and the upper reference mark of guiding catheter (7), to indicate ablation catheter (1) or/and the degree of depth of guiding catheter (7) intravasation and length, the width of indirect inspection organization of human body under ultrasonic or X ray image equipment; Ablation catheter (1) is or/and guiding catheter (7) is arranged different developing marks for distinguishing ablation catheter (1) or/and guiding catheter (7) under ultrasonic or X ray image equipment; Or/and each absolute construction (8) is arranged different developing marks for distinguishing different absolute construction (8) under ultrasonic or X ray image equipment; Ablation catheter (1) is or/and guiding catheter (7) is also arranged labelling for distinguishing different axial-rotation states under ultrasonic or X ray image equipment.

13. kidneys according to claim 1 go sympathetic nerve ablation catheter system, it is characterized in that: ablation catheter (1) is fixed by catheter body section (4) and joystick (2) upper end, the lower end of joystick (2) or downside have energy exchange joint (201), collect described energy exchange joint (201) from melting the wire of head (9), conduit, microwave antenna or the optical fiber center cavity through joystick (2).

14. kidneys according to claim 1 or 13 go sympathetic nerve ablation catheter system, it is characterized in that:

Described joystick (2) comprises lever (241) or/and lever (271); Or described joystick (2) only comprises lever (217);

Lever (271) is provided with the control knob (237) for controlling controllable bending tune (5) deformation or console panel (238), described control knob (237) or console panel (238) are connected with guide wire (11), by moving up and down of control knob (237), or realize the control to controllable bending tune by the multiple-directional rotating of console panel (238); Or/and comprise annular control knob (250), described annular control knob (250) is connected with ablation catheter (1) by connecting rod (251), described connecting rod (251) is arranged in the gathering sill (244) of joystick (2), by moving up and down annular control knob (250), realize the control to absolute construction (8); Also comprise the buffer structure that can prevent excessive tractive;

Described guiding catheter control handle (27) comprises lever (271') and lever (273), lever (271') is provided with the control knob (237') for controlling guiding catheter (7) deformation or console panel (238'), described control knob (237') or console panel (238') are connected with guide wire (11), by moving up and down of control knob (237'), or realize the control to guiding catheter (7) by the multiple-directional rotating of console panel (238'); Also comprise the buffer structure that can prevent excessive tractive; Described guiding catheter control handle (27) and joystick (2) comprise can take off groove tooth slide construction, groove tooth slide construction can be taken off and give prominence to tenon (243) by the pressed hook formation (242) on the draw-in groove (293) on lever (273), cone column recesses (292), snap ring (297), hole clipping (299) and lever (241), cone cylinder, undertaken breaking by groove tooth slide construction can be taken off and combine.

15. kidneys according to claim 1 go sympathetic nerve ablation catheter system, it is characterized in that: described in melt the joint (311) that generating means (3) is provided with the joint of energy output and sensor signal input, be also provided with and external power supply phase ground joint (321) simultaneously; Described melt generating means (3) containing by carry out touch screen control controling parameters and partly or entirely information can show the button (330) of display (320) thereon and regulating parameter.