CN102901833A - Biochemical analysis tester and testing method - Google Patents
Biochemical analysis tester and testing method Download PDFInfo
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- CN102901833A CN102901833A CN2012103045804A CN201210304580A CN102901833A CN 102901833 A CN102901833 A CN 102901833A CN 2012103045804 A CN2012103045804 A CN 2012103045804A CN 201210304580 A CN201210304580 A CN 201210304580A CN 102901833 A CN102901833 A CN 102901833A
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
Abstract
The invention provides a biochemical analysis tester comprising a main control unit and at least two mutually independent testing units. The main control unit is respectively connected with a master power source controlling switch, a data output/input controlling system, and the testing units. Each testing unit at least comprises a sample delivery device and a light source device. The invention also provides an analysis testing method with the analysis tester. With the analysis tester and the analysis testing method provided by the invention, the testing speed in unit time can be improved, and a testing result is accurate. The biochemical analysis tester provided by the invention can be used in tests of a series of physiological and biochemical indexes such as glucose, cholesterol, high-density fatty acid, low-density fatty acid, triglyceride, uric acid, bilirubin, total protein, hemoglobin,acetone body, and the like.
Description
Technical field
The present invention relates to biochemical analysis tester and method of testing for biochemical analysis tester and method of testing, especially the Fast Measurement biochemical indicator of measuring the detection of clinical physiological index.
Background technology
Along with the progress of science and technology, the bedside in-vitro diagnosis experiment (POCT:Point of Care Testing) in the laboratory medicine field is arisen at the historic moment and is rapidly developed.20th century, " soak and read " dry chemical method (dip-and-read) of occurring of the fifties referred to the liquid detecting sample directly is added on the dry type reagent strip, moisture with sample causes specific chemical reaction on the reagent strip as solvent, thereby carries out the method for sample analysis.Biochemical dry type test paper method also plays a significant role in the fast detecting at the scene with characteristics such as its finding speed easy to carry, simple to operate are fast.Introduction along with immune response and molecular biotechnology, the check field of medical science dry type test paper method expands to the detection of blood sugar, gestation, blood coagulable status, myocardial damage, acid base equilibrium, infectious diseases etc., and medicine concentration monitor (TMD), alcohol content detection, thrombotest, the analysis of Blood Biochemical Indexes, infectious disease sieve, hormonal readiness and microchip DNA diagnosis and drug abuse detection etc. during operation.Rely on ocular estimate to judge the testing result of dry chemical test paper, can only be as qualitatively judging or semiquantitative judgement.Therefore for to make the interpretation of quick detection test paper more accurate, supporting miniaturization detecting instrument progressively grows up with it.These detecting instruments are easy and simple to handle, go out the result fast, accurately.And the resulting data of these detecting instruments can also realize remote wireless transmission to the laboratory computer management system or form electronic health record.
US Patent No. 4780283 has disclosed a kind of dry chemical test paper analyser.This analyser comprises fixed detection light source, loads the hemispherical workbench of test paper bar.By the interaction between the spring hemispherical workbench being transported to the detection light source place detects.Owing to just utilized the mechanicals efforts between the spring, not only require to have very accurately control procedure in production, increase production cost, and utilized the interaction very difficult control reaction reagent bar of spring and the tram between the detection light source, affected testing result.And hemispherical structure has increased the volume of whole analytical instrument.On the other hand, spring is short serviceable life, needs regular replacing spring, and this can make troubles to the user of instrument.
U.S. Praxsys Biosystems Inc. company has developed a kind of tachysynthesis detection system that quantitative and qualitative analysis is judged that can be used for, in US Patent No. 6136610, disclose, this system by detector and with it supporting Test paper box form.This system uses single channel, namely once only can detect single clinical samples.Because this detecting instrument once can only detect an index, so detection efficiency is lower.
Chinese patent application 200910160639.5 discloses a kind of multi-channel portable colloidal gold test paper device for quick testing, mainly comprises: 4 independently sense channel, ARM data processor, keyboard and LCD parts.The pick-up unit of this invention can be finished multiple test item fast and high-throughout.But 4 of this Chinese patent application independently sense channel and whole detector be an integral body, the instrument user can not arbitrarily change test event by changing sense channel.
Chinese patent application 200410052202.7 discloses a kind of quick diagnosis lateral flow assays system and method, this detection system comprises 1 master unit and 1 to 20 test module, and being connected to host computer by USB or blue teeth wireless receiver, host computer moves by the software control detector.This patented claim also discloses and has been designed to relatively independent relation between master unit and the test module, and when master unit broke down, all proving installations can be removed and ressemble with another master unit.It is a very complicated process that the described test module of this patented claim disassembles from master unit, needs a lot of parts of breakdown.On the other hand, described test module is not the structure of a sealing, when the sample when retention in the test module that is removed has test or test agent, the sample that these are residual or reagent can be exposed in the environment, environment around not only having polluted also can consist of operating personnel's life security dangerous.
In existing detector, often all be single pass, namely once can only detect single patient's sample.This single pass detector is limited at the sample of unit interval build-in test, when processing the extensive health check-up of large contingent, tends to cause a large amount of delays of medical examiner.
In carrying out the application of sample process of sample detection, test paper is placed in first on the experiment desktop, then drips sample.Because thereby test paper all can thinlyyer can tightly be bonded on the laboratory table, when dripping sample, in the time of need to again picking up test paper, relatively difficulty needs the more time of cost, has incured loss through delay correct detection time.
On the other hand, if operator's error, with regard to the open detection program, external interference light will enter the test position like this, causes testing result inaccurate, particularly utilizes the detector of optical detection principle in the situation of not fastening test gate.
Summary of the invention
One of purpose of the present invention provides the proving installation that a kind of medical test is used; this device comprises base 101; design was transported the movably microscope carrier 102 of testing element and to be positioned at movably light source transmitter-receiver device 103 above the microscope carrier 102 in being used on the base 101; microscope carrier 102 can move back and forth at predefined track; light source transmitter-receiver device 103 can near and away from microscope carrier 102, the motion track of microscope carrier 102 and light source transmitter-receiver device 103 or the extended line of motion track mutually intersect in same plane or the orthogonal projection in same plane intersects mutually.
Described proving installation, wherein, when certain fixed area on the microscope carrier 102 is positioned at orthogonal projection place of light source transmitter-receiver device 103 just, microscope carrier 102 stops mobile, then light source transmitter-receiver device 103 is near that fixed area on the microscope carrier 102, detect, detect finish after again away from that fixed area on the microscope carrier 102.
Described proving installation, wherein, proving installation also comprises the support 104 of at least one fixing design on base 101, described light source transmitter-receiver device 103 designs are on described support 104.
Described proving installation, wherein, described proving installation comprises at least two motors, drives respectively described microscope carrier 102 and light source transmitter-receiver device 103.
Described proving installation, wherein, described electro-motor is stepper motor 107,130.
Described proving installation wherein, is fixed with rack-plate 111 at microscope carrier 102, is installed on the described support with the stepper motor 107 of gear 108, and the gear 108 on the stepper motor is connected with a joggle with the rack-plate 111 on the microscope carrier 102, drives microscope carrier 102 and moves.
Described proving installation wherein, is designed with left socle 104, right support 105 at base 101, is designed with upper bracket 106 at described left socle and right support, and 103 designs of light source transmitter-receiver device are on upper bracket 106.
Described proving installation, wherein, light source transmitter-receiver device 103 comprises the optical coupled switch 132 that light source emitter 131, optical pickup apparatus and control light source transmitter-receiver device move.
Described proving installation, wherein, described smooth lotus root switch 132 has lightening hole 133, has shutter 134 on the light source transmitter-receiver device, and described shutter 134 has the lightening hole of blocking 133 and leaves 133 two positions of lightening hole with respect to lightening hole 133.
Described proving installation, wherein, in the light source transmitter-receiver device 103 downward operational processs, be positioned at lightening hole 133 tops of light lotus root switch 132 when shutter 134, this moment, light path was unimpeded, power supply keeps power supply state always, make light source emitter 131 under electro-motor 130 rotates, continue to move downward, when shutter 134 has stopped the lightening hole 133 of light lotus root switch 132, light path is cut off, thereby close the power supply of the electro-motor 130 of light source transmitter-receiver device 103, and open light source transmitter-receiver device 103 and carry out the analysis of sample.
Described proving installation, wherein, base 101 fixedly is designed with track base 112, and microscope carrier 104 fixedly is designed with guide rail 113, and described guide rail 113 slides with track base 112 and makes up.
Two of purpose of the present invention provides a kind of medical detecting analyzer, comprise a master control set 10 and at least one proving installation 100, wherein, master control set 10 comprises supply unit 11, control device, testing result output unit and the storage chamber 15 that is no less than the proving installation number, proving installation 100 comprises the microscope carrier 102 and the light source transmitter-receiver device 103 that is positioned at microscope carrier 102 tops for carrying detecting element and detection sample, proving installation 100 be placed in the storage chamber 15 of master control set and with the supply unit 11 of master control set, control device and testing result output unit are electrically connected, the microscope carrier 102 of control device control proving installation moves back and forth in certain direction, light source transmitter-receiver device 103 with the direction of microscope carrier 102 moving direction approximate vertical do near and away from the movement of microscope carrier, and detect the change color parameter that places the detecting element on the microscope carrier 102, then this parameter is delivered to control device, after the control device processing, via testing result output unit output detections result.
Described medical detecting analyzer, wherein, proving installation 100 can repeated multiple times extraction and group enter master control device 10.
Described medical detecting analyzer wherein, is designed with rail structure between the inwall of the storage chamber 15 of the outer wall of proving installation 100 and master control set 10.
Described medical detecting analyzer, wherein, rail structure comprises guide rail 16 and the slide block structure 120 that is placed on storage chamber 15 inwalls and the proving installation outer wall, described slide block structure 120 can be in the guide rail 16 interior slips of storage chamber 15.
Described medical detecting analyzer comprises two or more proving installation 100, and each proving installation can detect the identical or different parameter that detects sample with kind, also can detect the identical or different parameter that variety classes detects sample.
Described medical detecting analyzer also comprises at least one reagent storage unit 18, and this reagent storage unit 18 is interior can place some detecting elements.
Described medical detecting analyzer, wherein, the storage chamber 15 in the master control set 10 is optionally accommodated proving installation 100 or reagent storage unit 18, and namely storage chamber 15 can not only be taken in proving installation 100, also can take in reagent storage unit 18.
Described medical detecting analyzer, wherein, the testing result output unit comprises printer 14 and/or display 13.
Described medical detecting analyzer, wherein, control device comprises touch-screen display 13, this touch-screen display 13 provides operation interface.
Described medical detecting analyzer also comprises the latching system of master control set 10 with proving installation 100 snap closes or release.
Described medical detecting analyzer, wherein, described latching system comprises three permanent magnet blocks, wherein the first and second magnetic patch are placed in the shell of master control set 10, the 3rd magnetic patch is fixed on the shell of proving installation 100, when proving installation is housed in the storage chamber 15 of master control set when interior fully, three magnetic patch are arranged in straight line substantially, the second magnetic patch is between the first and the 3rd magnetic patch, second opposite with the two relative utmost point magnetic of the 3rd magnetic patch (for example one is the S utmost point, another is the N utmost point), first two utmost point Magnetic Phase same (for example all being the N utmost point or the S utmost point) that magnetic patch is relative with the second magnetic patch, the first magnetic patch can move with the line of proving installation (100) along three magnetic patch.
Three of purpose of the present invention provides a kind of Biochemical Analyzer, comprise a master control set 10 and at least one proving installation 100, master control set 10 comprises at least one storage chamber 15, proving installation 100 is incorporated in the described storage chamber 15, be designed with guide rail 16 in the storage chamber 15, proving installation 100 is designed with slide block structure, described slide block structure can be in the guide rail 16 interior slips of storage chamber 15, thus reposefully with proving installation 100 from shifting out in the storage chamber 15 or 100 groups of proving installations being entered in storage chamber 15.
Described Biochemical Analyzer, wherein, the two side of storage chamber 15 is designed with respectively guide rail 16, and perhaps the bottom design at storage chamber has guide rail 17, perhaps all is designed with guide rail in two side and the bottom of storage chamber.
Described Biochemical Analyzer, wherein, described slide block structure comprises the take-up housing 120 that designs in the side of proving installation base 101, is provided with slide block 121 in take-up housing 120, described slide block 121 can be in the guide rail 16 interior slips of storage chamber 15.
Described Biochemical Analyzer, wherein, described slide block structure comprises the take-up housing 120 that designs in the bottom of proving installation base 101, is provided with slide block 121 in take-up housing 120, described slide block 121 can be in the guide rail 17 interior movements of storage chamber 15.
Described Biochemical Analyzer comprises two or more proving installation 100 and the quantity storage chamber 15 that is no less than the proving installation number.
Described Biochemical Analyzer wherein, is separate work between the described proving installation 100.
Described Biochemical Analyzer also comprises at least one reagent storage unit 18, has at least a storage chamber 15 to be used for taking in reagent storage unit 18, and remaining storage chamber is used for taking in proving installation 100.
Described Biochemical Analyzer, wherein, described reagent storage has reagent storage frame 19 in the unit.
Described Biochemical Analyzer wherein, fastens by magnetic block lock catch structure between described proving installation 100 or reagent storage frame 19 and the master control set 10 mutually.
Described Biochemical Analyzer, wherein, described magnetic block lock catch structure comprises three permanent magnet blocks, wherein the first magnetic patch 151 and the second magnetic patch 152 are placed in the shell of master control set 10, the 3rd magnetic patch 153 is fixed on the shell of proving installation 100, when proving installation is housed in the storage chamber 15 of master control set when interior fully, three magnetic patch are arranged in straight line substantially, the second magnetic patch 152 is between the first magnetic patch 151 and the 3rd magnetic patch 153, the two relative utmost point magnetic of the second magnetic patch 152 and the 3rd magnetic patch 153 are opposite, and (for example one is the S utmost point, another is the N utmost point), first magnetic patch 151, two utmost point Magnetic Phases relative with the second magnetic patch 152 are with (for example all being the N utmost point or the S utmost point), and the first magnetic patch 151 can move along the line of three magnetic patch.
Described Biochemical Analyzer, wherein, 151 designs of the first magnetic patch are on proving installation backboard 126, and 152 designs of the second magnet piece are in master control set 10, being designed with two bracing frames, 154, the three magnetic patch 153 at the master control set bonnet is connected with bracing frame 154 by spring leaf 155.
Described Biochemical Analyzer, wherein, master control set 10 also comprises primary power 11, master switch 12, guidance panel 13 and printer 14, master switch 12, guidance panel 13 and printer 14 are electrically connected with primary power 11.
Described Biochemical Analyzer, wherein, master control set 10 also comprises usb 19, fan 20 and general supply access port 21.
Described Biochemical Analyzer, wherein, proving installation 100 comprises a base 101, the microscope carrier that transport test strip 102 of design on base 101, be positioned at the light source transmitter-receiver device 103 of microscope carrier 102 tops, on base 101, at least fixedly be designed with a support, described light source transmitter-receiver device 103 designs are on described support, at least one side at microscope carrier 102 is designed with rack-plate 111 regularly, be designed with stepper motor 107 at described support, gear 108 on the stepper motor is connected with a joggle with the rack-plate 111 on the microscope carrier 102, and the stepper motor driven gear rotates, and the gear driven microscope carrier is mobile in proving installation.
Described Biochemical Analyzer, wherein, described light source transmitter-receiver device 103 comprises the optical coupled switch 132 of motor 130, light source emitter 131, optical pickup apparatus and control light source transmitter-receiver device movement position that promotion light source emitter 131 moves up and down.
Described Biochemical Analyzer, wherein, described master control set 10 and proving installation 100 electric connections.
Described Biochemical Analyzer, wherein, master control set 10 is connected by power connector 140 with proving installation 100.
Four of purpose of the present invention provides another kind of Biochemical Analyzer, comprise master control set 10 and the proving installation 100 that is electrically connected with master control set 10, it is characterized in that: master control set 10 comprises supply unit 11 and control device, and proving installation 100 comprises microscope carrier movably 102 and is positioned at the light source transmitter-receiver device 103 that can do on the microscope carrier to approach and move away from microscope carrier.
Described Biochemical Analyzer, wherein, described control device comprises shell with master control set 10 by hinged guidance panel 13, the guidance panel 13 0-180 degree that can overturn take hinge as rotating shaft.
Described Biochemical Analyzer, wherein, the operation interface of described guidance panel 13 is downward, and when guidance panel 13 overturns 90-180 when spending take hinge as rotating shaft, its guidance panel 13 is in opening.
Described Biochemical Analyzer, wherein, the operation interface of described guidance panel 13 upwards, when guidance panel 13 overturns 0-90 when spending take hinge as rotating shaft, its guidance panel 13 is in opening.
Described Biochemical Analyzer, wherein, guidance panel 13 is provided with support 24, and the two ends of support 24 make the angle of shell maintenance between between the 0-90 degree of guidance panel 13 and master control set 10 respectively against the shell of guidance panel 13 and master control set 10.
Described Biochemical Analyzer, wherein, described guidance panel 13 is LCD or LED display panel.
Described Biochemical Analyzer, wherein, described guidance panel 13 is touch-screen LCD or the LED display panels that can carry out touch screen operation.
Described Biochemical Analyzer wherein, is provided with storage chamber 15 in the master control set 10, proving installation 100 inserts storage chamber in the mode of drawer or extracts out from storage chamber.
Described Biochemical Analyzer, wherein, the outer wall of the inwall of storage chamber 15 and proving installation 100 is provided with the railroad that cooperatively interacts.
Described Biochemical Analyzer, wherein, rail structure comprises guide rail 16 and slide block structure 120, described slide block structure can be mobile at guide rail.
Five of purpose of the present invention provides a kind of magnetic block lock catch structure, comprise at least three permanent magnet blocks, wherein the first magnetic patch 151 is fixed on the first device, the second magnetic patch 152 is fixed on the second device, the 3rd magnetic patch 153 is placed on the second device movably, when the first and second devices are in mutually close position, three magnetic patch are arranged in straight line substantially, the second magnetic patch 152 is between the first magnetic patch 151 and the 3rd magnetic patch 153, the two relative utmost point Magnetic Phases of the second magnetic patch 152 and the 3rd magnetic patch 153 are with (for example all being the N utmost point or the S utmost point), two utmost point magnetic that the first magnetic patch 151 is relative with the second magnetic patch 152 are different, and (for example one is the S utmost point, another is the N utmost point), the 3rd magnetic patch 153 can move along the line of three magnetic patch.
Described magnetic block lock catch structure wherein, is designed with the spring leaf 155 that two supports 154 and two ends are movably attached to support 154 on the second device, described the 3rd magnetic patch 153 is fixedly connected with spring leaf 155.
Described magnetic block lock catch structure wherein, is designed with two slide bars 156 and can slides at slide bar 156 by slide bar button 157 with slide bar button 157, the three magnetic patch 153 that are enclosed within on the slide bar 156 on the second device.
Described magnetic block lock catch structure wherein, is designed with two springs, 158, the three magnetic patch 153 and links to each other with spring 158 by snak link 159 on the second device.
Six of purpose of the present invention provides a kind of magnetic block lock catch structure that utilizes and makes two devices mutual snap closes and the method for separating, described magnetic block lock catch structure comprises at least three permanent magnet blocks, wherein the first magnetic patch 151 is fixed on the first device, the second magnetic patch 152 is fixed on the second device, the 3rd magnetic patch 153 is placed on the second device movably, when the first and second devices are in mutually close position, three magnetic patch are arranged in straight line substantially, the second magnetic patch 152 is between the first magnetic patch 151 and the 3rd magnetic patch 153, the two relative utmost point Magnetic Phases of the second magnetic patch 152 and the 3rd magnetic patch 153 are with (for example all being the N utmost point or the S utmost point), two utmost point magnetic that the first magnetic patch 151 is relative with the second magnetic patch 152 are different, and (for example one is the S utmost point, another is the N utmost point), the 3rd magnetic patch 153 can move along the line of three magnetic patch, described method comprises the steps: 1) first device that will be fixed with described the first magnetic patch 151 is close to the second device that is fixed with described the second magnetic patch 152, and make described the 3rd magnetic patch 153 and described the second magnetic patch 152 keep distance enough far away, the first magnetic patch 151 is in the same place by magnetic-adsorption with the second magnetic patch 152, thereby with first device and the mutual snap close of the second device; 2) promotion the 3rd magnetic patch 153 is close to the second magnetic patch 152, mutual repulsive force between the 3rd magnetic patch 153 and the second magnetic patch 152 and the first magnetic patch 151, weaken the magnetic attraction between the first magnetic patch 151 and the second magnetic patch 153, thereby first device and the second device are separated from each other.
Seven of purpose of the present invention provides a kind of Biochemical Analyzer with magnetic block lock catch structure, comprise master control set 10 and proving installation 100, be provided with storage chamber 15 in the master control set 10, proving installation 100 is housed in the storage chamber 15, it is characterized in that: described magnetic block lock catch structure comprises at least three permanent magnet blocks, wherein the first magnetic patch 151 is fixed on the proving installation 100, the second magnetic patch 152 is fixed on the master control set 10, the 3rd magnetic patch 153 is placed on the master control set 10 movably, when master control set 10 and electricity testing device 100 are in mutually close position, three magnetic patch are arranged in straight line substantially, the second magnetic patch 152 is between the first magnetic patch 151 and the 3rd magnetic patch 153, the two relative utmost point Magnetic Phases of the second magnetic patch 152 and the 3rd magnetic patch 153 are with (for example all being the N utmost point or the S utmost point), two utmost point magnetic that the first magnetic patch 151 is relative with the second magnetic patch 152 are different, and (for example one is the S utmost point, another is the N utmost point), the 3rd magnetic patch 153 can move along the line of three magnetic patch.
Described Biochemical Analyzer wherein, is designed with two bracing frames 154 at master control set 10) the 3rd magnetic patch 153 is connected with bracing frame 154 by spring leaf 155.
Described Biochemical Analyzer, wherein, being designed with two slide bars, 156, the three magnetic patch 153 on the master control set 10 can slide at slide bar 156 by slide bar button 157.
Described Biochemical Analyzer wherein, is designed with two springs, 158, the three magnetic patch 153 and mutually conflicts by snak link 159 and spring 158 on the master control set 10.
Eight of purpose of the present invention provides a kind of method of testing that adopts Biochemical Analyzer to measure parameters of biological samples, and this method of testing may further comprise the steps: 1) opening power, and the Biochemical Analyzer start also enters the startup self-detection step; 2) after startup self-detection was passed through, Biochemical Analyzer entered preheating step; 3) when the probe temperature of Biochemical Analyzer satisfies predefined temperature conditions, prompting is put into testing element and is detected sample; 4) Biochemical Analyzer starts test; 5) after test is finished, output test result; 6) prompting is taken out used testing element and is detected sample; 7) whether prompting detects and finishes; 8) if select not finish, then prompting is put into new testing element and is detected sample, and then repeating step 4)-6); 9) if select to finish, then shutdown finishes test.
Described method of testing, wherein, described Biochemical Analyzer comprises master control set 10 and at least one proving installation 100, the startup self-detection step comprises whether the state that checks each equipment is normal, and the quantity of checkout device 100.
Described method of testing wherein, when the quantity of proving installation 100 is equal to, or greater than two, after the step that startup self-detection is passed through, before the preheating step, also comprises and selects to open the step which platform or which platform proving installation 100 are tested.
Described method of testing wherein, after having selected the step that proving installation 100 tests or behind the preheating step, also comprises the step that the test approaches that will carry out selected proving installation 100 is selected.
Described method of testing wherein, after putting into testing element and detecting sample, before analyser starts test, comprises that also the test approaches that will carry out selected proving installation 100 carries out the step of automatic decision.
Described method of testing wherein, is accompanied with the beacon information of test approaches on the testing element, automatic decision test approaches after the beacon information on the Biochemical Analyzer read test element.
Described method of testing, wherein, after each proving installation 100 is finished test, whether Biochemical Analyzer prompting test finishes, if select to finish, then closes this TV station proving installation 100, if do not carry out any selection, then this TV station proving installation cut out after the 100 idle schedule times.
Described method of testing, wherein, after whole proving installation 100 cuts out, the Biochemical Analyzer shutdown.
Described method of testing wherein, is provided with guide rail between the master control set 10 of Biochemical Analyzer and at least one proving installation 100, and at least one proving installation 100 can be in master control set 10 interior slips.
Described method of testing, wherein, Biochemical Analyzer also includes the identical or close reagent storage unit 18 of appearance profile and size and proving installation 100, be provided with the storage chamber 15 that profile and size and proving installation 100 and reagent storage unit 18 are complementary in the master control set 10, storage chamber can optionally be accommodated proving installation 100 or reagent storage unit 18, be that storage chamber 15 can not only be taken in proving installation 100, also can take in reagent storage unit 18.
Described method of testing wherein, is provided with guide rail between reagent storage unit 18 and the master control set 10.
Nine of purpose of the present invention is to provide a kind of biochemical analysis tester, comprise main control unit and at least two separate test cells, main control unit respectively with the general supply gauge tap, data output/input control system and test cell interconnect, each test cell comprises sample conveying device and light supply apparatus at least, described light supply apparatus comprises testing light source and top board, sample conveying device comprises the test paper pallet, the electro-motor of push to test test paper tray motion and control test paper pallet arrive the switch of detection position, and described test paper pallet is provided with heating arrangement.
Described biochemical analysis tester is equipped with a test cell door corresponding to each test cell, and the operation of closing certain test cell door can automatically start its corresponding test cell and carry out work.
Described biochemical analysis tester is provided with magnetic induction start device in each test cell, this magnetic induction start device comprises the magnetic patch that is arranged on the test cell door and is arranged on the interior magnetic induction switch of test cell.
Described biochemical analysis tester comprises for the fixing casing of main control unit and test cell, test paper application of sample operator's console is housed on this casing.
Described biochemical analysis tester, its test paper operator's console is the structure of a draw-in groove, comprises upper plate and lower plate, leaves the slit between upper plate and lower plate and is fit to the insertion of test paper ground.
Described biochemical analysis tester, the switch that its control test paper pallet arrives the detection position is optical coupled switch.
Ten of purpose of the present invention is to provide a kind of biochemical analysis method of testing, comprising:
1) opens the biochemical analysis tester, and test parameter is set, described biochemical analysis tester comprises main control unit and at least two separate test cells, main control unit interconnects with general supply gauge tap, data output/input control system and test cell respectively, and each test cell comprises sample conveying device and testing light source device;
The test paper that 2) will add sample is put into one of them test cell;
3) the biochemical analysis tester judges whether detection zone has test paper to exist;
4) the biochemical analysis tester judges whether the test cell door closes;
5) when test paper Already in detection zone and cell gate closed these two groups of information when all possessing, the biochemical analysis tester begins start detection and output detections result.
Described method of testing, wherein, the biochemical analysis tester also can just detect the start time and whether surpass the time that presets and judge; If overtime, then the biochemical analysis tester provides the information of again changing test paper; If not overtime, the biochemical analysis tester begins start detection and output detections result.
Described method of testing, wherein, testing light source sends test light, and judges by the reflected light information of pallet detection zone whether detection zone has test paper to exist; If no, the biochemical analysis tester provides the information that reapposes test paper.
Described method of testing, wherein, in test cell, be provided with magnetic induction start device, magnetic induction switch is sensed the field signal of magnetic patch on the cell gate, after field signal is delivered to main control unit, main control unit is judged the particular location of cell gate, if cell gate does not cut out, the biochemical analysis tester provides the again information of closing unit door.
11 of purpose of the present invention is to provide a kind of biochemical analysis tester, the test cell that comprises casing, fixes with casing, the test cell door corresponding with test cell, wherein test cell includes temperature control equipment, mechanical motion control device and detects light path device, it is characterized in that test cell is provided with by closing the test cell door with the test cell door corresponding with it and automatically starts the magnetic induction start device that test cell carries out work.
Described biochemical analysis tester, wherein, magnetic induction start device comprises the magnetic patch that is arranged on the test cell door and is arranged on the interior magnetic induction switch of test cell, when closing the test cell door, magnetic patch on the test cell door is near the magnetic induction switch that is arranged in the test cell, thereby open this magnetic induction switch, and then the startup test cell carries out work.
Described biochemical analysis tester, wherein, described magnetic patch material is magnet steel.
Described biochemical analysis tester, wherein, the mode that described magnetic patch is fixed with viscose or screw state is fixed is fixed on the cell gate.
Described biochemical analysis tester, wherein, magnetic patch is closed in the cell gate or is placed on outside the cell gate.
Described biochemical analysis tester, wherein, described sample conveying device comprises that carrying detects the pallet of test paper, one heat transfer plate is arranged below pallet, by this heat transfer plate the heat that heating arrangement produces is delivered to surveyed area, placed a lower lock block thermal insulation board below temperature-adjusting heating device the heat that heating arrangement produces is intercepted at this, electro-motor is fixed on the electro-motor fixed head, and the promotion pallet will detect test bar and deliver to predefined detection position.
Described biochemical analysis tester also comprises the optical coupled switch that arrives predefined detection position for the control pallet.
Described biochemical analysis tester, wherein, described heating arrangement is selected from the power resistor plate.
Described biochemical analysis tester comprises at least two test cells, and each test cell is corresponding to a described test cell door and a described magnetic induction start device.
12 of purpose of the present invention is to provide a kind of biochemical analysis tester, comprises casing and is installed in casing interior main control unit and test cell, it is characterized in that, at casing test paper application of sample operator's console is housed.
Described biochemical analysis tester, wherein, operator's console is the structure of a draw-in groove type.
Described biochemical analysis tester, wherein, operator's console is comprised of upper plate and lower plate, and leaves the slit between upper plate and the lower plate, is fit to the insertion of test paper.
Described biochemical analysis tester comprises two separate test cells at least.
Because adopt technique scheme, the present invention has brought following beneficial effect:
By mobile cooperate of the slide block on the proving installation in the master control set guide rail, can realize that proving installation is installed on the master control set or with proving installation to disassemble from master control set in the proving installation.This operating process is simple, convenient.
Because can also take in the reagent storage unit in the storage chamber, the operator can be placed on the reagent of needs in the reagent rack of reagent storage unit in advance, just can from described reagent storage frame, take out easily the reagent that needs during detection.If certain type proving installation is used for a long time, but then its corresponding reagent storage unit also long-term storage in master control set, form man-to-man relation with proving installation, prevent from misusing reagent.The reagent storage unit is incorporated in the master control set, so that operating table surface is unlikely to pile with reagent bottle, prevents the hazard events such as reagent bottle tipping.
Magnetic block lock catch structure of the present invention has utilized the two like magnetic poles attract each other of magnetic patch, the principle that the opposite sex is repelled each other, and has effectively realized the assembling between proving installation and the master control set.Magnetic block lock catch structure of the present invention does not need the operator to use a lot of strength, does not need the operator to dismantle such as a lot of screw nut etc. yet, and whole process is very simple and convenient.
The rack-plate that utilizes the stepper motor driven wheel to drive on the microscope carrier of the present invention moves, thereby drive the motion of test paper carrier bench, not only improved test speed, and the driving effect of stepper motor continuous and stable, can stablize and accurately microscope carrier is transported to the tram.
The track base that the bottom of microscope carrier is designed with on guide rail and the base is used, so that level and smooth the moving in proving installation of microscope carrier energy reduced the interference of noise.
Baffle plate of the present invention not only plays good protection to the test strips microscope carrier in the proving installation and light source transmitter-receiver device, makes microscope carrier and light source transmitter-receiver device avoid external force collision, prevents dust pollution.Simultaneously when proving installation is deposited separately, because proving installation is the structure of a sealing, when the sample when retention in the proving installation that is removed has test or test agent, reagent or sample residual on the microscope carrier can not be exposed in the external environment, prevent the pollution to surrounding environment and operator.
Biochemical Analyzer of the present invention also comprises the supporting structure for the support operation panel, because guidance panel when establishing, has thereafter stent support, the operator is when using panel button, and guidance panel can not cave in backward.
Beneficial effect of the present invention also comprises: 1) Biochemical Analyzer of the present invention adopts the pattern of a plurality of separate test cells, has increased the sample size of unit interval build-in test, improves detection efficiency.2) method of testing of the present invention has comprised a plurality of determining steps, has improved the accuracy that detects, and has reduced the inaccurate risk of test result that the manual operation mistake causes.3) comprised a magnetic induction start device at test cell of the present invention, not only can effectively guarantee like this when starting test, the test cell door is closed, also do not need simultaneously additionally to add other unit lock locking devices, just the test cell door can be closed closely, get rid of the interference of external light source.4) Biochemical Analyzer of the present invention, owing at instrument test paper application of sample operator's console has been installed, the bottom surface of test paper being affectedly bashful the position does not touch the experiment desktop, so that the easier test paper that has added sample of being affectedly bashful of operator.
Description of drawings
Fig. 1 Biochemical Analyzer synoptic diagram;
Fig. 2 Biochemical Analyzer guidance panel open mode synoptic diagram;
A view that proving installation is drawn out of in Fig. 3 Biochemical Analyzer;
The reagent storage cell schematics is arranged in Fig. 4 Biochemical Analyzer;
The rear structure synoptic diagram of Fig. 5 Biochemical Analyzer and proving installation;
The guidance panel of Fig. 6 Biochemical Analyzer is by the second design diagram of stent support;
The proving installation inner structure synoptic diagram of Fig. 7 Biochemical Analyzer;
The cut-open view of the proving installation of Fig. 8 Biochemical Analyzer A-A direction along the line;
The proving installation door of the proving installation of Fig. 9 Biochemical Analyzer is opened synoptic diagram;
The synoptic diagram that the first magnetic patch and the second magnetic patch attract each other in Figure 10 the first magnetic block lock catch structure;
The first magnetic patch and the separated synoptic diagram of the second magnetic patch in Figure 11 the first magnetic block lock catch structure;
Figure 12 the second magnetic block lock catch structure synoptic diagram;
The third magnetic block lock catch structure synoptic diagram of Figure 13;
Figure 14 Biochemical Analyzer test flow chart.
Figure 15 is the synoptic diagram of another embodiment of biochemical analysis tester of the present invention.
Figure 16 is the test cell door open mode synoptic diagram of biochemical analysis tester shown in Figure 15.
Figure 17 is biochemical analysis tester sectional view shown in Figure 15.
Figure 18 is test cell sectional view in the biochemical analysis tester shown in Figure 15.
Figure 19 is magnetic induction switch and the magnetic patch positional structure synoptic diagram on the test cell door shown in Figure 16.
Figure 20 is the hardware composition diagram of Biochemical Analyzer shown in Figure 15.
Figure 21 is the method for testing process flow diagram of Biochemical Analyzer shown in Figure 15.
Embodiment
The present invention will be described in detail below in conjunction with concrete accompanying drawing.These specific embodiments only are limited the enumerating under spirit of the present invention, do not get rid of one of ordinary skill in the art prior art and the present invention in conjunction with and other specific embodiments of producing.
As shown in Figure 1, Biochemical Analyzer 1 of the present invention comprises a master control set 10 and separate proving installation 100 more than or, and master control set 10 is connected with wire by electric connector 140 with proving installation 100.Each proving installation 100 can according to the instruction of master control set 10 transmission, be finished test item and testing result is transferred to master control set 10 outputs independently of one another.Be designed to relatively independent relation between each proving installation 100, the dismounting that proving installation 100 can be freely carries out repeatedly with master control set 10.
, include in the casing of master control set 10 and power to the each several part of Biochemical Analyzer after primary power 11(connects the external goods electricity consumption to shown in Figure 6 such as Fig. 1).Master control set 10 also includes master switch 12, guidance panel 13 and the printer 14 of analyser.Master switch 12, guidance panel 13 and printer 14 are electrically connected with primary power 11 respectively.Guidance panel 13 is touch display screens, both can show interface and the testing result of testing process, and the person's touch screen that is not convenient to operation again operates.
Be provided with side by side one or the storage chamber 15 that above size is substantially suitable with proving installation 100 in the casing of master control set 10.For proving installation can be pushed in the storage chamber 15 of master control set by quick flat quietly, at least the two side of storage chamber 15 is designed with respectively guide rail 16, perhaps the bottom design at storage chamber 15 has guide rail 17, perhaps all is designed with guide rail in two side and the bottom of storage chamber.Described guide rail cooperates with slide block or pulley (not shown) on the proving installation.When proving installation is assembled into master control set or from the process that master control set disassembles, slide block or pulley on the proving installation slide in guide rail, the guiding proving installation enters the storage chamber of master control set or leaves storage chamber 15.
As shown in Figure 4, also can put into the size and shape reagent storage unit 18 substantially suitable with proving installation 100 in the described storage chamber 15, described reagent storage unit 18 is interior can to arrange one or more reagent storage frame 19, be used for depositing the testing element of test usefulness, this testing element can be test agent or reagent barrel etc.The advantage of this design is, can be according to actual needs, and the storage chamber 15 whole installation testing devices 100 in the master control set 10, perhaps part installation testing device 100, other installation reagent storage unit 18, thus make design more flexible.Biochemical Analyzer 1 has as shown in Figure 4 comprised a master control set 10, two proving installations 100 and a reagent storage unit 18.As more changeable embodiment more, Biochemical Analyzer 1 can comprise a master control set 10, one to ten, even the proving installation more than ten 100 and one to ten, even the reagent storage unit 18 more than ten, and according to need arbitrarily combination of the quantity of proving installation 100 and storage unit 18.The reagent that the operator can need when detecting is placed in the reagent storage frame 19 in advance.When detecting, the operator can take out corresponding reaction reagent easily from the reagent storage unit of analyser.If proving installation is used for a long time, but then its corresponding reagent storage unit also long-term storage in master control set, form man-to-man relation with proving installation, prevent from misusing reagent.Reagent is all sorted out and is placed in the reagent storage unit in addition, so that operating table surface is unlikely to pile with reagent bottle, prevents the hazard events such as reagent bottle tipping.
Be equipped with USB interface 26, fan 20, general supply access port 21 etc. on the shell of master control set 10.For the proving installation 100 that is pushed into is stably remained in the storage chamber 15, the position of corresponding each proving installation can also comprise bonnet lock hole 22 on the bonnet of master control set.
To shown in Figure 9, proving installation 100 comprises a base 101 such as Fig. 7, transports microscope carrier 102 designs of test strip on base, and light source transmitter-receiver device 103 is positioned at the top of microscope carrier 102.Fixedly be designed with left socle 104 and right support 105 at base 101, left and right sides support surrounds microscope carrier 102 within it.Light source transmitter-receiver device 103 is installed on the support of the left and right sides, perhaps fixedly is designed with upper bracket 106 at left and right sides support, and light source transmitter-receiver device 103 is installed on the upper bracket 106.Microscope carrier 102 can move back and forth at predefined track; light source transmitter-receiver device 103 can near and away from microscope carrier 102, the motion track of microscope carrier 102 and light source transmitter-receiver device 103 or the extended line of motion track mutually intersect in same plane or the orthogonal projection in same plane intersects mutually.
Be designed with stepper motor 107 at least one support 104 or 105, gear 108 is housed on the stepper motor.The microscope carrier 102 that transports test strip comprises for the pallet 110 that carries test strip 109.At least one side at microscope carrier 102 is designed with rack-plate 111 regularly.Rack-plate 111 engagements on described gear 108 and the microscope carrier 102.When stepper motor is worked, order about driven wheel and rotate, and then order about rack-plate 111 and make linear running, thereby the microscope carrier that will link to each other with rack-plate is delivered to test zone or withdrawed from from test zone.Stepper motor is higher to the ratio of precision of motion, therefore when the motion of gear driven rack-plate, has not only improved the speed of transporting test paper, and has improved stability and the accuracy of test.
The medium position of base 101 fixedly is designed with track base 112, guide rail 113 on this track base 112 and the test strips microscope carrier 102 is used, microscope carrier 102 can slide along track base in proving installation, arrives the detection position or withdraws from test zone thereby transport test-strips.Described guide rail 113 designs in the bottom of microscope carrier 102.
Be positioned at microscope carrier test strips test zone below a temperature control equipment 114 is arranged.When the environment temperature of test does not meet predefined temperature range, temperature control equipment will be regulated temperature (for example heating) automatically, make the temperature of test environment meet predefined temperature range.Temperature control equipment comprises resistive heating device, and transmits temperature by potsherd or sheet metal.
The left and right sides of proving installation base 101 can also respectively be mounted with a take-up housing 120, and take-up housing 120 is bolted on the base 101.Slide block 121 fixing designs are on take-up housing 120, this slide block 121 can be free to slide in the guide rail 16 of storage chamber 15 sidewalls, thereby drive whole proving installation in storage chamber 15 interior movements, proving installation is pushed into storage chamber and prepares to carry out the detection of analyte, perhaps is moved out of storage chamber.Can also be arranged on the bottom of base with the take-up housing of slide block, be used with bottom guide track 17 in the storage chamber.As the change design, take-up housing 120 and slide block 121 also can be an integral body, can also be bars that matches with guide rail 16.
For better protection test microscope carrier and light source transmitter-receiver device, can also respectively be designed with baffle plate 122-126 all around, i.e. right baffle plate 122, right baffle-plate 123, overhead gage 124, front apron 125 and backboard 126 at proving installation 100.Be designed with a proving installation door 127 at front apron 125, proving installation door 127 can be connected through the hinge with front apron 125.When proving installation did not use or detecting, the proving installation door was closed.When the test strips microscope carrier in the proving installation need to transport test strip, the proving installation door was opened, and the handled easily person deposits or take out test paper.Described baffle plate plays good protection to the test strips microscope carrier in the proving installation and light source transmitter-receiver device, makes microscope carrier and light source transmitter-receiver device avoid external force collision, and can prevent dust pollution.When proving installation during by whole taking out, reagent or sample residual on the microscope carrier can not be exposed in the external environment, prevent the pollution to environment simultaneously.
Light source transmitter-receiver device 103 comprises the preferred stepper motor of electro-motor 130(that promotion light source transmitter-receiver device moves up and down), light source emitter 131.Light source transmitter-receiver device 103 also comprises the optical coupled switch 132 of control light supply apparatus movement position, and described smooth lotus root switch 132 is electrically connected with described electro-motor 130, is used for controlling described electro-motor 130 operations and braking.Described smooth lotus root switch 132 has lightening hole 133, and the light source transmitter-receiver device has shutter 134.Described shutter 134 has the lightening hole of blocking 133 and leaves 133 two positions of lightening hole with respect to lightening hole 133.In the downward operational process of light source transmitter-receiver device, when shutter 134 is positioned at lightening hole 133 tops of light lotus root switch 132, this moment, light path was unimpeded, and power supply keeps power supply state always, and light supply apparatus continues to move downward under electro-motor 130 rotates.When shutter 134 had stopped the lightening hole 133 of light lotus root switch 132, light path was cut off, thereby closed the power supply of electro-motor 130, and light supply apparatus is no longer descending, opened simultaneously 131 pairs of samples of sample detection light source and carried out determination and analysis.
Each proving installation 100 can also comprise independently microprocessor, can carry out the movement position, test environment temperature and the heating plate heating supervisor that including but not limited to for example to control light source emitter, monitoring pallet, and by data transmission interface to extraneous the transmission of data.
Proving installation 100 also can comprise power interface and data transmission interface, realizes to proving installation power supply and test transmission result.Proving installation 100 is available integrated electric connector 140 also.Described electric connector is the device that power interface and data transmission interface are integrated, and this just makes proving installation have more space to deposit other accessories, has also reduced the operation of producing, and enhances productivity.Proving installation is connected with master control set by electric connector, accepts master control set proving installation is powered, or transfer data to the data output device of master control set.The electric connector of proving installation also can be connected on other the data output device.
The detection light source that adopts on each proving installation can be identical or different.When the detection light source that adopts when a plurality of proving installations is identical, can improve speed and the efficient of detection.If the detection light source that proving installation adopts is different, each proving installation can be measured the identical or different biochemical parameter of identical or different samples, thereby realizes a tractor serves several purposes.The master control set that other are any and the array mode between the proving installation all are suitable.
In order to guarantee that proving installation well is fixed on the master control set, can arrange at proving installation and master control set proving installation is fixed to buckle structure on the master control set.Described buckle structure can be fixed form, buckle snap close or the magnetic patch snap close of screw thread snap close (for example bolt and nut, screw and threaded hole).The structure of described magnetic patch snap close to shown in Figure 13, comprises at least three magnetic patch, the first magnetic patch 151, the second magnetic patch 152 and the 3rd magnetic patch 153 such as Figure 10.151 designs of the first magnetic patch are on first device, and the second magnetic patch 152 and 153 designs of the 3rd magnetic patch are on the second device.The magnetic different (being respectively the S utmost point and the N utmost point) of two faces that the first magnetic patch 151 is relative with the second magnetic patch 152, the Magnetic Phase of two faces that the second magnetic patch 152 is relative with the 3rd magnet 153 is with (be all the S utmost point or be all the N utmost point).The first magnetic patch 151, the second magnetic patch 152 and the 3rd magnetic patch 153 are roughly overlapping perpendicular to the projection on the direction of its opposite face.If with two mutual snap closes of device when living, to push to the second device of the second magnetic patch 152 close with the first device of the first magnetic patch 151, first device finally is in the same place by magnetic-adsorption with the second device, and at this moment, the 3rd magnetic patch 153 is away from the second magnetic patch 152.If two devices are separated from each other, it is close that push the 3rd magnetic patch 153 to second magnetic patch 152 this moment, utilize the mutual repulsive force between the 3rd magnetic patch 153 and the second magnetic patch 152 and the first magnetic patch 151, weakened the magnetic attraction between the first magnetic patch 151 and the second magnetic patch 153, thereby first device and the second device are separated from each other.
Biochemical Analyzer of the present invention such as Figure 10 are to embodiment shown in Figure 11, and 151 designs of the first magnetic patch are on the backboard 126 of proving installation 100.The second magnetic patch 152 is entrenched in the bonnet lock hole 22 of master control set 10.Be designed with two bracing frames 154 at the master control set bonnet, support frame as described above 154 designs respectively the both sides at bonnet lock hole.The 3rd magnetic patch 153 is connected with bracing frame 154 by spring leaf 155.The magnetic different (being respectively the S utmost point and the N utmost point) of two faces that the first magnetic patch 151 is relative with the second magnetic patch 152, the Magnetic Phase of two faces that the second magnetic patch 152 is relative with the 3rd magnetic patch 153 is with (be all the S utmost point or be all the N utmost point).State in the storage chamber 15 of shown in Figure 10 is proving installation 100 is pushed into master control set 10, at this moment, there is a natural attraction between the sexes because of magnet for the first magnetic patch 151 and the second magnetic patch 152, and this magnetic attraction and can not skidded off from master control set so that proving installation inhales on master control set firmly.As shown in figure 11, when needs are extracted proving installation 100 out, the 3rd magnetic patch 153 is pushed away to the second magnetic patch direction, because the polarity of two faces that the second magnetic patch 152 is relative with the 3rd magnetic patch 153 is identical, and the polarity of the face that the 3rd magnetic patch 153 is relative with the first magnetic patch 151 also is identical, according to the principle of the two like magnetic poles repel each other of magnet, 153 pairs of the first magnetic patch of the 3rd magnetic patch and the second magnetic patch have a repulsive interaction, have weakened the magnetic attraction between the first magnetic patch 151 and the second magnetic patch 152.Close along with the 3rd magnetic patch 153, this repulsive force can basic neutralisation the first magnetic patch 151 and the second magnetic patch 152 between magnetic attraction.Thereby proving installation 100 just can be extracted out from the storage chamber of master control set at an easy rate.
Figure 12 is the another kind of embodiment of magnetic block lock catch structure, and the 3rd magnetic patch 153 can slide at slide bar 156 by slide bar button 157.Figure 13 is the another kind of embodiment of magnetic block lock catch structure, and the 3rd magnetic patch 153 is conflicted mutually by snak link 159 and spring 158, and spring has the state that is compressed and unfold by the 3rd magnetic patch.
Testing process as shown in figure 14 between master control set and the proving installation.Workflow is: opening power at first, the Biochemical Analyzer start also enters the startup self-detection program, after startup self-detection finishes, enters preheating program, when the probe temperature of Biochemical Analyzer meets predefined temperature range, detector is in the wait test mode, and the operator selects the proving installation that need to test, put into the test paper bar after, analyser starts test, test outputs test result after finishing, and takes out the test paper bar.Then again put into new test paper bar if also will carry out the detection of next sample, the mensuration of a beginning new round.If all samples has all been tested and has been finished, then shutdown.
It below is another embodiment of the present invention.
Shown in Figure 15 to 21, biochemical analysis tester 1a comprises main control unit 50a and at least two test cell 100a of being installed in the casing 2a.On casing, corresponding to each test cell 100a test cell door 3a is installed.
The sample conveying device 110a of test cell 100a comprises that carrying detects the pallet 114a of test paper, and a heat transfer plate 115a is arranged below pallet, by this heat transfer plate the heat that heating arrangement 116a produces is delivered to surveyed area.Described heating arrangement 116a can be selected from the electric elements such as power resistor plate.Below temperature-adjusting heating device 116a, placed a lower lock block thermal insulation board 117a, the heat that produces on the heating arrangement has been intercepted at this, no longer transmitted toward other positions.Electro-motor 118a is fixed on the electro-motor fixed head 119a.When electro-motor is opened, promote plate nut and move up and down.Sample conveying device 110a will detect test bar by pallet 114a and deliver to predefined detection position, preferably arrive predefined detection position by optical coupled switch 121a control pallet 114a.Described optical coupled switch 121a has lightening hole 122a, and described pallet 114a has lower limb 123a and is positioned at described lightening hole 122a top.Described lower limb 123a has the lightening hole of blocking 122a and leaves two positions of lightening hole 122a with respect to lightening hole 122a.Be positioned at as the lower limb 123a of pallet 114a above the lightening hole 122a of optical coupled switch 121a, then light path is unimpeded, and this moment, the electro-motor power supply kept power supply state always.Under electro-motor 118a rotated, pallet 114a continued to move upward.After pallet 114a continued to rise and touches detection light source device 112a, because detection light source device 112a maintains static, pallet just can not continue to move ahead, and light supply apparatus can produce pallet 114a and continue downward pressure.But optical coupled switch also moves upward continuing under the drive of electro-motor, until the lower limb 123a of pallet 114a has stopped the lightening hole 122a of optical coupled switch 121a.After lightening hole was blocked, light path just was cut off, thereby closed the power supply of electro-motor.At this moment, detect test paper and arrived the detection position, the biochemical analysis tester is opened sample detection light supply apparatus 112a and is carried out the analysis of sample.
Described testing light source device 111a comprises testing light source 112a and upper holder block 113a.Be equipped with for described detection test paper is produced pressure described upper holder block 113a and described lower extrusion plate 117a.In a specific embodiment of the present invention, pressure is generally 1kgf/cm
2-3kgf/cm
2, that better is 2 kgf/cm
2Described light supply apparatus has the effect of two aspects at least: 1) light is imported into to the conversion zone that detects test paper, and receive the reflected light of reaction zone.2) test zone to pallet transmits light, and receives reflected light information, and reflected light information is offered system, and is first-class to be tested in order to judge whether the detection test paper has been placed on test paper carrier bench.
In test cell, also be provided with the magnetic induction start device of biochemical analysis tester open detection.The magnetic induction signal that magnetic induction start device produces is connected on the main control unit.In one embodiment, magnetic induction start device comprises the magnetic patch 11a on the cell gate that is arranged on the magnetic induction switch 10a in the test cell and is arranged on test cell, and its material is selected from magnet steel, and magnet is worked as.When cell gate cuts out, magnetic induction switch 10a senses the field signal of magnetic patch on the cell gate, field signal is delivered to main control unit after, main control unit is judged the particular location of cell gate, for example whether cell gate closed or open, thus by main control unit to whether start detection judges.
On the other hand, the material of biochemical analysis tester casing can chosen from Fe or steel etc. can produce with magnetic patch the material of absorption affinity, an iron block etc. perhaps is installed in test cell.When the test cell door is closed, be subjected to the magneticaction of contact point magnet, the magnetic patch that is installed on the cell gate can be pull-in on cell gate on the casing of main frame firmly, thereby realizes the sealed of cell gate.Therefore the biochemical analysis tester does not need to acquire other unit lock locking device again.
The modes such as magnetic patch is fixed with viscose or screw is fixing are fixed on the cell gate.Magnetic patch can be closed in the cell gate or be placed on outside the cell gate.
Test paper application of sample operator's console 5a also is housed on the casing 2a of analysis tester.When adding sample, test paper can temporarily leave on the described test paper operator's console 5a.Operator's console is a draw-in groove type structure in one embodiment, and described operator's console is comprised of upper plate 6a and lower plate 7a, and leaves slit 8a between upper plate and the lower plate, and described slit spacing just in time is the thickness of test paper or larger than test paper thickness a little.The fore-end of test paper is blocked in the slit of operator's console, and the application of sample position of test paper and the place of being affectedly bashful are all in the outside of operator's console, and the bottom surface of test paper being affectedly bashful the position does not touch the experiment desktop.Very convenient like this operator's application of sample and pick up test paper.When application of sample, the operator at first is stuck in test paper in the draw-in groove of operator's console, then carries out application of sample.Because the part of being affectedly bashful of test paper is soared aloft, after adding sample, the operator can pick up the test paper that is added with sample easily, this test paper is put on the detection platform of test cell.Described test paper operator's console can be installed in below, side or the top of test cell door.
Among the embodiment as shown in figure 20, described biochemical analysis tester comprises independently test cell of a main control unit and three.Main control unit is connected with power supply, printer, display system, USB interface, Parameters Input Unit etc.Main control unit also is connected with three test cells respectively.Test cell is independently finished detection separately, and test result is transferred to main control unit, by main control unit output detections result.Test cell comprises baffled photometer, mechanical driving device and temperature control equipment etc.
Biochemical analysis method of testing as described in Figure 21 comprises:
1) opens the Biochemical Analyzer tester, and test parameter is set, described biochemical analysis tester comprises main control unit and at least two separate test cells, main control unit interconnects with analyser power control switch, data output device, input control system and test cell respectively, and each test cell comprises sample conveying device 110a and testing light source device 111a.
The test paper that 2) will add sample is put into one of them test cell.
3) the biochemical analysis tester judges whether detection zone has test paper to exist, if do not have, the biochemical analysis tester provides the information that reapposes test paper.
4) the biochemical analysis tester judges whether the test cell door closes, if do not have, the biochemical analysis tester provides the information of closing unit door.
5) when test paper Already in detection zone and cell gate closed these two groups of information when all possessing, the biochemical analysis tester begins start detection and output detections result.
In one embodiment, the biochemical analysis tester also can just detect the start time and whether surpass the time that presets and judge after receiving test paper Already in detection zone and cell gate have been closed these two groups of information.If overtime, then the biochemical analysis tester provides the information of again changing test paper.If not overtime, the biochemical analysis tester begins start detection and output detections result.
In test process, each test cell independently detects, and does not interfere with each other, thereby has improved test speed, can detect more sample at one time.
The biochemical analysis tester utilizes the light supply apparatus of test cell to come the interpretation detection zone whether to place test paper.Testing light source sends test light, and judges by the reflected light information of pallet detection zone whether detection zone has test paper to exist.If no, the biochemical analysis tester provides the information that reapposes test paper.
The biochemical analysis tester judges by the magnetic induction signal whether the test cell door is shut.When cell gate cuts out, magnetic induction switch 10a senses the field signal of magnetic patch on the cell gate, field signal is delivered to main control unit after, main control unit is judged the particular location of cell gate, for example whether closed or open, thus by main control unit to whether start detection judges.
The detection of a series of physiological and biochemical indexs such as Biochemical Analyzer of the present invention and method of testing can be used for glucose, cholesterol, high density fat is sour, low density fat is sour, triglyceride, uric acid, cholerythrin, total protein, haemoglobin, ketoboidies.
Claims (10)
1. biochemical analysis tester, comprise main control unit and at least two separate test cells, main control unit interconnects with general supply gauge tap, data output/input control system and test cell respectively, each test cell comprises sample conveying device and light supply apparatus at least, described light supply apparatus comprises testing light source and top board, sample conveying device comprises the electro-motor of test paper pallet, push to test test paper tray motion and the switch that control test paper pallet arrives the detection position, and described test paper pallet is provided with heating arrangement.
2. biochemical analysis tester according to claim 1, it is characterized in that, this biochemical analysis tester is equipped with a test cell door corresponding to each test cell, and the operation of closing certain test cell door can automatically start its corresponding test cell and carry out work.
3. biochemical analysis tester according to claim 2, it is characterized in that, be provided with magnetic induction start device in each test cell, this magnetic induction start device comprises the magnetic patch that is arranged on the test cell door and is arranged on the interior magnetic induction switch of test cell.
4. biochemical analysis tester according to claim 1 is characterized in that, this biochemical analysis tester comprises for the fixing casing of main control unit and test cell, test paper application of sample operator's console is housed on this casing.
5. biochemical analysis tester according to claim 4 is characterized in that, the test paper operator's console is the structure of a draw-in groove, comprises upper plate and lower plate, leaves the slit between upper plate and lower plate and is fit to the insertion of test paper ground.
6. biochemical analysis tester according to claim 1 is characterized in that, the switch that described control test paper pallet arrives the detection position is optical coupled switch.
7. biochemical analysis method of testing comprises:
1) opens the biochemical analysis tester, and test parameter is set, described biochemical analysis tester comprises main control unit and at least two separate test cells, main control unit interconnects with general supply gauge tap, data output/input control system and test cell respectively, and each test cell comprises sample conveying device and testing light source device;
The test paper that 2) will add sample is put into one of them test cell;
3) the biochemical analysis tester judges whether detection zone has test paper to exist;
4) the biochemical analysis tester judges whether the test cell door closes;
5) when test paper Already in detection zone and cell gate closed these two groups of information when all possessing, the biochemical analysis tester begins start detection and output detections result.
8. method of testing according to claim 7 is characterized in that, the biochemical analysis tester also can just detect the start time and whether surpass the time that presets and judge; If overtime, then the biochemical analysis tester provides the information of again changing test paper; If not overtime, the biochemical analysis tester begins start detection and output detections result.
9. method of testing according to claim 7 is characterized in that, testing light source sends test light, and judges by the reflected light information of pallet detection zone whether detection zone has test paper to exist; If no, the biochemical analysis tester provides the information that reapposes test paper.
10. method of testing according to claim 7, it is characterized in that, in test cell, be provided with magnetic induction start device, magnetic induction switch is sensed the field signal of magnetic patch on the cell gate, after field signal is delivered to main control unit, main control unit is judged the particular location of cell gate, if cell gate does not cut out, the biochemical analysis tester provides the again information of closing unit door.
Priority Applications (2)
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| CN201210304580.4A CN102901833B (en) | 2011-09-21 | 2012-08-24 | Biochemical analysis tester and testing method |
| CN201510243006.6A CN104897912B (en) | 2012-08-24 | 2012-08-24 | biological sample analysis tester |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102817102 | 2011-09-21 | ||
| CN2011102817102A CN102374969A (en) | 2011-09-21 | 2011-09-21 | Magnetic block lock catch structure, using method thereof and application thereof to biochemical analyzer |
| CN201110281710.2 | 2011-09-21 | ||
| CN201210285607X | 2012-08-13 | ||
| CN201210285607 | 2012-08-13 | ||
| CN201210285607.X | 2012-08-13 | ||
| CN201210304580.4A CN102901833B (en) | 2011-09-21 | 2012-08-24 | Biochemical analysis tester and testing method |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510243006.6A Division CN104897912B (en) | 2012-08-24 | 2012-08-24 | biological sample analysis tester |
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| CN102901833A true CN102901833A (en) | 2013-01-30 |
| CN102901833B CN102901833B (en) | 2015-07-08 |
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| CN201210304580.4A Active CN102901833B (en) | 2011-09-21 | 2012-08-24 | Biochemical analysis tester and testing method |
| CN201220423576.5U Expired - Lifetime CN202975023U (en) | 2011-09-21 | 2012-08-24 | Biochemical analysis test instrument |
| CN201220423632.5U Expired - Lifetime CN202794195U (en) | 2011-09-21 | 2012-08-24 | Biochemical analysis test instrument |
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| CN201220423632.5U Expired - Lifetime CN202794195U (en) | 2011-09-21 | 2012-08-24 | Biochemical analysis test instrument |
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| WO (6) | WO2013041003A1 (en) |
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| CN112964886B (en) * | 2019-12-13 | 2024-02-23 | 深圳迈瑞生物医疗电子股份有限公司 | Analyzer control method, analyzer system, and computer-readable storage medium |
Also Published As
| Publication number | Publication date |
|---|---|
| CN202794195U (en) | 2013-03-13 |
| CN202916288U (en) | 2013-05-01 |
| WO2013041005A1 (en) | 2013-03-28 |
| WO2013041003A1 (en) | 2013-03-28 |
| CN102901833B (en) | 2015-07-08 |
| CN202975023U (en) | 2013-06-05 |
| WO2013041004A1 (en) | 2013-03-28 |
| WO2013041008A1 (en) | 2013-03-28 |
| WO2013041007A1 (en) | 2013-03-28 |
| WO2013041006A1 (en) | 2013-03-28 |
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