CN102973277A - Frequency following response signal test system - Google Patents
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Abstract
The invention relates to a frequency following response signal test system. The system is characterized by comprising a computer, a data acquisition (D/A) card, a multichannel A/D acquisition card, a miniature speaker, a miniature microphone, a pre-amplifier, body surface optical disk electrodes, a high input-impedance stage, a bioelectricity amplifier and earplugs. An acoustic meatus sound pressure monitoring module and a frequency following response signal extraction testing module are arranged inside the computer. The acoustic meatus sound pressure monitoring module is used for collecting and recording sound pressure signals inside acoustic meatuses, and off-line analyzing and processing collected sound pressure signals, namely comparing the collected sound pressure signals with the preset judging criteria, and getting rid of signal sections which disagree with acoustic meatus normal sound pressure. A frequency following response signal test platform is used for collecting FFR signals and off-line analyzing and processing collected FFR signals, namely pre-screening and processing the FFR signals which correspond to acoustic meatus normal sound pressure signal segments, and extracting and displaying the FFR signals of a tester are finished. The frequency following response signal test system can be widely applied to the detection of the FFR signals.
Description
Technical field
The present invention relates to a kind of audition and electric physiology test macro, particularly follow the response signal test macro about a kind of frequency.
Background technology
Frequency is followed response (Frequency Following Response, FFR) be in the steady-state response of scalp record brain stem to acoustical signal, its master record method and clinical brainstem auditory evoked potential (the auditory brainstem response that is brought out generation by transient state sound commonly used, ABR) recording method is identical, is slightly larger than brainstem auditory evoked potential incubation period.It is the brain stem neuron to the concentrated expression of the phase-locked response of cyclic component in the sound, with brain the perception of acoustic tones height and tone intensity attribute is had close ties.
The research of FFR and use and can roughly be divided into two aspects, the one, brain is to the coding of complex sound, and the 2nd, brain is to coding and the perception of acoustic tones information.Complex sound refers to contain the sound with human environment feature of harmonic structure, dynamic amplitude modulation and fast time-frequency fluctuation, all contains a large amount of complex sound compositions such as voice, music etc.The sound of transient state and stable state all may be the constituent of complex sound.Such as the syllable that consists of for auxiliary vowel, the part of consonant is transient components normally, and the vowel part then is periodic stable state composition, and other complex sound that comprises cyclic component also comprises the chord in the music etc.The ABR(that is brought out by complex sound has and is called complex ABR in the document, be abbreviated as cABR) be that the research brain is to the important means of complex sound coding, corresponding to the transient state in the complex sound and two kinds of compositions of stable state, cABR also is comprised of transient state and the response of stable state persistence, stable state persistence response wherein is frequency and follows response, be accompanied by the research of cABR, frequency is followed response and is applied to brain to auxiliary vowel syllable coding research on mechanism, and in the research of the diseases such as special language obstacle, reading disorder and infantile autism pedigree obstacle.
Research to tone coding and perception is another important main line of FFR correlational study, people to the research of FFR from take single pure tone as stimulation sound, the complexsound that develops into two pure tones brings out, thereby observed the distortion product among the FFR, to bringing out with synthetic vowel, comprise the time-independent vowel of frequency content and the time dependent vowel of tone etc. again.2004, Krishnan makes of the sound of four tones of Chinese syllable " yi " stimulates acousta induction to send out generation FFR, and from the FFR signal, extract fundamental frequency information with the autocorrelogram method, the fundamental frequency that obtains is very consistent with stimulation sound fundamental frequency information, the tone information that becomes voice when the FFR signal has carried tone is described, has reflected the encoding function of brain stem to tone information.
To different audition crowds' tone perception Hearing display and FFR signal thereof relatively in, a series of researchs have proved that from several angles the information that contains the FFR signal can reflect that these crowds are in the difference aspect the tone perception.Krishnan and Gandour have carried out good summary at survey article in 2009 to this.Four tones that Krishnan etc. have compared Chinese syllable " yi " are the FFR response that causes among the experimenter of Chinese and english at mother tongue, discovery is that the tone intensity index extracted experimenter's the FFR of Chinese and FFR signal are followed order of accuarcy to the pitch of stimulation sound and all be better than the crowd that mother tongue is English from mother tongue, proved that FFR has reflected in the perception of the tonality feature special to language, mother tongue is that the Chinese crowd is with respect to non-Chinese native crowd's advantage.The research of Wong etc. is pointed out: be non-ly to have among the crowd who transfers language at mother tongue, the musician than the frequency of unmusical family follow the response pitch of Chinese language tone is followed more accurate, proved that FFR has reflected the impact of Listening Training experience on the tone perception, moreover, the research of Song etc. is also found: after the adult who to mother tongue is English used the short-term training of Chinese language tone, their frequency was followed response following of Chinese language tone pitch is become more accurate.After speech training, this change of FFR signal has illustrated the plasticity of brainstem auditory on the one hand, on the other hand, illustrate that also the FFR signal can reflect brain stem observantly to the coding characteristic of acoustical signal, simultaneously so that people can expect the good correlation that may have between FFR signal and people's the tone perception more.Except different crowd is compared, Krishnan has observed population of subjects under the alternative sounds condition, to the perception of tone significance and the relation between the FFR in the FFR and behavioristics's index sign of research to the tone significance.Research has been synthesized a series of different cycles rule degree that have with iteration Ripple Noise (iterated ripplesnoise) method, namely can cause the sound of different tone significance perception.Experiment is measured the tone significance of these perception of sound the frequency discrimination threshold value of sound fundamental frequency indirectly with the experimenter, obtain when using the correlation analysis that weight is arranged to compare to experimental data, having dependency between the tone significant indexes of from the FFR signal, extracting and its behavioristics tolerance.
Existing research points out that the FFR signal has carried the information of brain stem to the acoustic tones coding.The FFR signal contain enough information with between the reflection different crowd because the difference of the tone perception that audition experience causes or the population of subjects difference to tone significance information under different sound conditions characterizes, the FFR signal has brain stem that enough acuities form with the Listening Training of reflection short-term to the variation of acoustic information system simultaneously.These phenomenon explanations FFR signal may have potential using value in the assessment of cochlear implant wearer tone perception, a kind of behavioristics's objective evaluation method test, that contain the tone perception of abundant neural activity information that is different from might be provided.Be widely used at present the test of psychoacoustic behavioristics and carry out the assessment of tone perception, there are a series of deficiencies in appraisal procedure based on this.At first, the psychoacoustics experiment needs the conscious cooperation of experimenter to finish the relevant task of audition usually, and experimental result is subject to the impact of numerous subjective factorss, so that reliability decrease; Secondly, psychoacoustics is measured and need to be taken multiple measurements the performance of experimenter in same (class) task accurately, and experimentation is comparatively complicated, and it is larger to carry out difficulty in clinical crowd; Again, it is various that the psychoacoustics experimental technique changes, and psychoacoustics experimental technique that each research is used is difficult to unified, and in the experiment that relates to linguistic data, used corpus also is not quite similar, and this is to relatively having caused certain difficulty between the different research methoies; At last, the psychoacoustics experimental technique can only be assessed the effect that method is used, and the information directly related with the perception neural activity can not be provided, and the directive function that it plays method exploitation is very limited.Therefore, estimating the pitch perception by the test of FFR signal also has great importance.
In the existing domestic and international technology, there is no about the system by FFR test tone perception.At present, the instrument relevant with FFR or ABR etc. has Neuroscan, Biosemi and TDT in the home sale.BioSemi mainly is hardware system, the software support system that is not equipped with data acquisition and automatically carries out signal screening and processing, and later data is processed relatively difficulty for the user of psychology or medical science, therefore is not suitable for the automatic collection of FFR signal; TDT is mainly used in gathering the ABR that click brings out, and domestic a lot of hospitals use, and are also multiplex in psychoacoustic experiment in addition, but is used for the actually rare of FFR signals collecting.In the existing research, Aiken etc. as stimulating system, gather scalp FFR response with Neuroscan with TDT, and have no the signal with TDT collection FFR.In addition, TDT itself is not equipped with stimulates software and automatic acquisition software, does not still belong to the system that can carry out complete FFR signal testing.Neuoscan is the maximum brand of Chinese user, and nearly having had at present, 70 laboratorys relate to the fields such as psychology, medical science, brain-computer interface, signal processing, sports psychology using.But the screening that the stimulus artifact during its acquired signal reaches the FFR signal all needs artificial manually removal, and expensive.For present present situation, in the urgent need to developing a kind of FFR detection system perfect, that can automatically screen primary signal efficiently.
Summary of the invention
For the problems referred to above, the purpose of this invention is to provide a kind of simply, efficiently frequency of complete acquisition high s/n ratio and follow response signal, and have simultaneously an auditory meatus sound pressure signal monitoring function can follow the response signal test macro to the frequency that the FFR signal carries out automatic screening.
For achieving the above object, the present invention takes following technical scheme: a kind of frequency is followed the response signal test macro, it is characterized in that: it comprises computer, D/A capture card, multichannel A/D capture card, acoustic sensor, preamplifier, body surface CD electrode, high input-impedance stage, bioelectric amplifier and earplug, and described acoustic sensor comprises Microspeaker and mini microphone; Described computer connects described D/A capture card and multichannel A/D capture card by the corresponding data interface, the input of described Microspeaker is connected with the outfan of described D/A capture card, the outfan of described Microspeaker is plugged in the described earplug by sound pipe, the input of described mini microphone is plugged in the described earplug by the transmission sound pipe, and the outfan of described mini microphone is connected with the input of described multichannel A/D capture card by described preamplifier; Described body surface CD electrode comprises the recording electrode that is arranged on subject's head, be arranged on the reference electrode at experimenter's ear ear-lobe mastoid process place of earplug homonymy and be arranged on the ground electrode at experimenter's place between the eyebrows place, described recording electrode, reference electrode and ground electrode are connected outfan and are connected with the input of described high input-impedance stage respectively, and the outfan of described high input-impedance stage is connected by the input of described bioelectric amplifier with described multichannel A/D capture card; Frequency is set in the described computer follows the response signal test platform, described frequency is followed the response signal test platform and is comprised that test parameter arranges module, test signal generation module, test signal stimulating module, auditory meatus acoustic pressure monitoring modular and frequency and follows response signal extraction detection module; Described test parameter arranges frequency and the intensity that module is used for arranging stimulation sound, described test signal generation module generates corresponding digital stimulus signal according to the stimulation sound parameter that arranges, and send it to described test signal stimulating module, described test signal stimulating module sends digital stimulus signal to described D/A capture card, described D/A capture card converts digital stimulus signal to the aanalogvoltage stimulus signal, and the aanalogvoltage stimulus signal sent to described Microspeaker, described Microspeaker is converted to stimulus signal with the aanalogvoltage stimulus signal, and the sound stimulus signal sent in people's ear by described earplug, described auditory meatus acoustic pressure monitoring modular and frequency are followed response signal extraction detection module and simultaneously signal are gathered, described auditory meatus acoustic pressure monitoring modular is used for gathering and the interior sound pressure signal of record auditory meatus, and the sound pressure signal that gathers is carried out off-line analysis process, the sound pressure signal and the predefined judgment criterion that are about to gather compare, rejecting does not meet the signal segment of the normal acoustic pressure of auditory meatus, described frequency is followed response signal and is extracted detection module for gathering the FFR signal, and the FFR signal that gathers is carried out off-line analysis process, namely the corresponding FFR signal of the signal segment of the normal acoustic pressure of auditory meatus is carried out prescreen and processing, finish extraction and the demonstration of experimenter FFR signal.
Described auditory meatus acoustic pressure monitoring modular comprises that auditory meatus acoustic pressure acquisition module, auditory meatus acoustic pressure logging modle, auditory meatus acoustic pressure judge module, auditory meatus acoustic pressure reject module and display module as a result; Described mini microphone carries out the acoustical signal in the auditory meatus that receives to send to described preamplifier after the acoustic-electric conversion, described preamplifier amplifies signal and it is sent to described auditory meatus acoustic pressure acquisition module through described multichannel A/D capture card, described auditory meatus acoustic pressure acquisition module sends signal to described auditory meatus acoustic pressure logging modle, described auditory meatus acoustic pressure logging modle is used for the sound pressure level that record collects, and send it to described auditory meatus acoustic pressure judge module, described auditory meatus acoustic pressure judge module and auditory meatus acoustic pressure are rejected module sound pressure signal are carried out the off-line analysis processing, be specially: described auditory meatus acoustic pressure judge module is judged the sound pressure level that gathers according to predefined judgment criterion, and judged result is sent to described auditory meatus acoustic pressure reject module, the sound pressure signal that described auditory meatus acoustic pressure rejecting module will satisfy described judgment criterion is rejected, and remaining sound pressure signal sends to described as a result display module demonstration after will rejecting.
Described judgment criterion need to satisfy following three conditions simultaneously: the maximum of the sound pressure signal that 1) collects and the difference of minima adopt outside the scope of the difference that stimulates theoretical acoustic pressure maximum corresponding to sound intensity ± 6dB SPL and minima; The maximum of the sound pressure signal that 2) collects is greater than acoustic pressure maximum corresponding to adopt stimulation sound intensity+6dB SPL; 3) sound pressure signal is equally divided into five sections by acquisition time in the auditory meatus that will be recorded in the time of will sending stimulation sound, the maximum of a certain section sound pressure signal is peaked 75% less than five sections whole acoustic pressures, and perhaps the minima of a certain section sound pressure signal is greater than 75% of five sections whole acoustic pressure minima.
Described frequency is followed response signal and is extracted detection module and comprise FFR signals collecting logging modle, FFR signal processing module and display module as a result; The recording electrode of described body surface CD electrode, reference electrode and ground electrode are surveyed the FFR signal of subject's head, and send it to described high input-impedance stage and obtain the FFR voltage signal, described high input-impedance stage sends to described bioelectric amplifier with the FFR voltage signal and carries out filtering, processing and amplifying, and the FFR voltage signal behind the filter and amplification sent to described multichannel A/D capture card, described multichannel A/D capture card is converted to the FFR digital signal with the FFR voltage signal and sends to described FFR signals collecting logging modle, described FFR signals collecting logging modle sends to described FFR signal processing module with the FFR digital signal, described FFR signal processing module carries out off-line analysis to the FFR digital signal data to be processed, obtain experimenter's FFR signal, and the FFR signal that extracts is sent to described as a result display module demonstration.
Described FFR signal processing module comprises measures screening module, signal de-noising module, signal-to-noise ratio (SNR) estimation module and data selection module; Described measurement screening module is used for rejecting each test section and does not meet the measurement data that imposes a condition, and remaining signal sends to described signal de-noising module after will rejecting, described signal de-noising module is carried out respectively Wiener filtering, coherence average and bandpass filtering treatment with the FFR digital signal of each test section that the experimenter tests, and the signal after will processing sends to described signal-to-noise ratio (SNR) estimation module; Described signal-to-noise ratio (SNR) estimation module is calculated the signal to noise ratio of FFR digital signal, and the signal-to-noise ratio settings signal to noise ratio screening conditions according to the FFR digital signal that calculates, and described signal to noise ratio screening conditions are sent to described data selection module, described data selection module is rejected the excessively low FFR signal of signal to noise ratio according to described signal to noise ratio screening conditions.
The present invention is owing to take above technical scheme, it has the following advantages: 1, the present invention includes each hard ware measure equipment and frequency and follow the response signal test platform, the experimenter when detecting with the recording electrode of body surface CD electrode, ground electrode and reference electrode are placed on corresponding test position, the FFR signal that the collection of body surface CD electrode stimulates acousta induction to send out, and the FFR signal that gathers passed through high input-impedance stage successively, bioelectric amplifier and multichannel A/D capture card send to frequency and follow response signal and gather extraction module and process, the present invention only needs an acquisition channel (three electrodes) just can realize frequency is followed the acquisition and processing of response signal, therefore can be objective, easy, complete extraction experimenter's FFR signal efficiently.2, frequency of the present invention is followed response signal when gathering extraction module the FFR signal that gathers being processed, can automatically finish screening and rejecting to the FFR signal by measuring screening module, signal de-noising module, signal-to-noise ratio (SNR) estimation module and data selection module, compare with existing artificial manually removing method, not only improved and extracted the efficient of FFR signal, and can obtain the FFR signal of high s/n ratio.3, because small motion may occur in subject's head in test process, thereby cause earphone that small displacement occurs in auditory meatus, perhaps affect the good contact of body surface CD electrode and skin, for in the present FFR test macro to the defective in the FFR detection method under the sonic stimulation response, the present invention is provided with auditory meatus acoustic pressure monitoring modular, by auditory meatus acoustic pressure monitoring modular can to the FFR signal simultaneously in the auditory meatus of acquisition and recording sound pressure signal carry out analyzing and processing, by the sound pressure signal that does not meet the normal acoustic pressure of auditory meatus in the auditory meatus is rejected, thereby reject the frequency corresponding with undesired auditory meatus sound pressure signal section and follow response signal, only the corresponding FFR signal of the signal segment of the normal acoustic pressure of auditory meatus is carried out prescreen and processing, the FFR signal processing module is by measuring screening, signal de-noising, signal-to-noise ratio (SNR) estimation, carry out the steps such as data selection according to signal to noise ratio screening foundation, not only efficiently solve in the follow-up signal processing stimulation sound is alignd, signal to noise ratio is lower, the problems such as testing complex, and the further signal to noise ratio that improves the FFR signal that detects.The present invention can be widely used in the detection to the FFR signal.
Description of drawings
Fig. 1 is structural representation of the present invention, and wherein, the electroacoustic screened room is experimental situation;
Fig. 2 is the structural representation of auditory meatus acoustic pressure monitoring modular of the present invention;
Fig. 3 is that frequency of the present invention is followed the structural representation that response signal is extracted detection module;
Fig. 4 is FFR signal processing module structural representation of the present invention.
The specific embodiment
Below in conjunction with drawings and Examples the present invention is described in detail.
As shown in Figure 1, the present invention includes computer 1, a D/A capture card 2, a multichannel A/D capture card 3, an acoustic sensor 4, a preamplifier 5, one mass color disc electrode 6, a high input-impedance stage 7, a biological electric amplifier 8 and a soft earplug (not shown) that is mounted with the windows system; Acoustic sensor 4 comprises a Microspeaker 41 and a mini microphone 42.For sound and external sound in experimenter's auditory meatus are isolated, the input of the outfan of Microspeaker 41 and mini microphone 42 is plugged in the same earplug.
Computer 1 of the present invention connects respectively the input of D/A capture card 2 and the outfan of multichannel A/D capture card 3 by the corresponding data interface, D/A capture card 2 is converted to analogue signal with digital signal and sends it to Microspeaker 41, and multichannel A/D capture card 3 converts respectively the multichannel analog signals that receives to digital signal and sends it to computer 1 each interior module and processes.
Microspeaker 41 of the present invention comprises two electro-acoustic transducers, the input of each electro-acoustic transducer connects the outfan of D/A capture card 2, the outfan of each electro-acoustic transducer connects earplug by a sound pipe, electro-acoustic transducer converts electrical stimulation signal to stimulus signal, is used for bringing out frequency and follows response signal.Microspeaker 41 can adopt the various products of prior art, the ER2 insert earphone that adopts Etymotic company to produce when detecting such as the present invention, and it has between 106dB SPL above lasting fan-out capability, 16kHz bandwidth of operation and the above ear of 70dB and isolates.
Body surface CD electrode 6 of the present invention is used for frequency acquisition and follows response signal, it comprises that one is arranged on the recording electrode at Cz place, subject's head central point (hairline in the volume), and one is arranged on the ground electrode that is arranged on experimenter's place between the eyebrows Fpz place with the reference electrode and at experimenter's ear ear-lobe mastoid process place of earplug homonymy.
High input-impedance stage 7 of the present invention is used for improving the input impedance of testing circuit, is conducive to record bioelectrical signals.
Bioelectric amplifier 8 of the present invention is used for that the frequency that body surface CD electrode 6 collects is followed response signal and carries out filtering and processing and amplifying.Wherein, the outfan of recording electrode, reference electrode and ground electrode in the input difference connector mass color disc electrode 6 of high input-impedance stage 7, the outfan of high input-impedance stage 7 connects the input of bioelectric amplifier 8, and the outfan of bioelectric amplifier 8 is by the input of a TRS interface connecting multi-channel A/D capture card 3.The gain of bioelectric amplifier 8 of the present invention can be selected according to actual needs, is not construed as limiting at this.
The computer 1 interior frequency that arranges is followed response signal test platform 9, and frequency is followed response signal test platform 9 and comprised that a test parameter arranges module, a test signal generation module, a test signal stimulating module, an auditory meatus acoustic pressure monitoring modular and a frequency and follows response signal extraction detection module.
Test parameter arranges frequency and the intensity that module is used for arranging stimulation sound; The test signal generation module generates corresponding digital stimulus signal according to the stimulation sound parameter that arranges, and sends it to the test signal stimulating module; The test signal stimulating module sends digital stimulus signal to D/A capture card 2, D/A capture card 2 converts digital stimulus signal to the aanalogvoltage stimulus signal, and the aanalogvoltage stimulus signal sent to a wherein electro-acoustic converter, electro-acoustic converter is converted to stimulus signal with the aanalogvoltage stimulus signal, and the sound stimulus signal is sent in people's ear by earplug; Auditory meatus acoustic pressure monitoring modular and frequency are followed response signal extraction detection module and simultaneously signal are gathered, auditory meatus acoustic pressure monitoring modular is used for gathering and the interior sound pressure signal of record auditory meatus, and the sound pressure signal that gathers is carried out off-line analysis process, the sound pressure signal and the predefined judgment criterion that are about to gather compare, and reject the signal segment that does not meet the normal acoustic pressure of auditory meatus.Frequency is followed response signal and is extracted detection module for gathering the FFR signal, and the FFR signal that gathers is carried out off-line analysis process, namely the corresponding FFR signal of the signal segment of the normal acoustic pressure of auditory meatus is carried out prescreen and processing, finish extraction and the demonstration of experimenter FFR signal.
As shown in Figure 2, in above-described embodiment, auditory meatus acoustic pressure monitoring modular comprises that auditory meatus acoustic pressure acquisition module 911, auditory meatus acoustic pressure logging modle 912, auditory meatus acoustic pressure judge module 913, auditory meatus acoustic pressure reject module 914 and display module 915 as a result; Mini microphone 41 carries out the acoustical signal in the auditory meatus that receives to send to preamplifier 5 after the acoustic-electric conversion, 5 pairs of signals of preamplifier amplify and it are sent to auditory meatus acoustic pressure acquisition module 911 through multichannel A/D capture card 3, auditory meatus acoustic pressure acquisition module 911 sends signal to auditory meatus acoustic pressure logging modle 912, auditory meatus acoustic pressure logging modle 912 is used for the sound pressure level that record collects, and send it to auditory meatus acoustic pressure judge module 913, auditory meatus acoustic pressure judge module 913 and auditory meatus acoustic pressure are rejected 914 pairs of sound pressure signals of module and are carried out the off-line analysis processing, be specially: auditory meatus acoustic pressure judge module 913 is judged the sound pressure level that gathers according to predefined judgment criterion, and judged result is sent to the auditory meatus acoustic pressure reject module 914, auditory meatus acoustic pressure rejecting module 914 will satisfy the sound pressure signal of judgment criterion to be rejected, and remaining sound pressure signal sends to as a result display module 915 demonstrations after will rejecting.
Judgment criterion can be set according to the actual experiment situation, the judgment criterion of the embodiment of the invention need to satisfy following three conditions simultaneously: the maximum of the sound pressure signal that 1) collects and the difference of minima adopt and stimulate sound intensity 83dB SPL(to stimulate sound intensity to arrange according to practical situation, the stimulation sound intensity value that the embodiment of the invention adopts is 83dB SPL) ± scope of the difference of theoretical acoustic pressure maximum corresponding to 6dB SPL and minima outside; The maximum of the sound pressure signal that 2) collects is greater than stimulating acoustic pressure maximum corresponding to sound intensity 83dB SPL+6dB SPL; 3) sound pressure signal is equally divided into five sections by acquisition time in the auditory meatus that will be recorded in the time of will sending stimulation sound, the maximum of a certain section sound pressure signal is peaked 75% less than five sections whole acoustic pressures, and perhaps the minima of a certain section sound pressure signal is greater than 75% of five sections whole acoustic pressure minima.
As shown in Figure 3, in the various embodiments described above, frequency is followed response signal and is extracted detection module and comprise FFR signals collecting logging modle 921, FFR signal processing module 922 and display module 923 as a result; FFR signal processing module 922 comprises measures screening module 9221, signal de-noising module 9222, signal-to-noise ratio (SNR) estimation module 9223 and data selection module 9224; The recording electrode of body surface CD electrode 6, reference electrode and ground electrode are surveyed the FFR signal of subject's head, and send it to high input-impedance stage 7 and obtain the FFR voltage signal, high input-impedance stage 7 sends to bioelectric amplifier 8 with the FFR voltage signal and carries out filtering, processing and amplifying, for example can select the hardware bandpass filtering of 1～3000Hz and through 50000 times of amplifications, and the FFR voltage signal behind the filter and amplification sent to multichannel A/D capture card 3, multichannel A/D capture card 3 is converted to the FFR digital signal with the FFR voltage signal and sends to FFR signals collecting logging modle 921, FFR signals collecting logging modle 921 sends to FFR signal processing module 922 with the FFR digital signal, 922 pairs of FFR digital signal datas of FFR signal processing module carry out off-line analysis to be processed, obtain experimenter's FFR signal, and the FFR signal that extracts is sent to as a result display module 923 demonstrations.
As shown in Figure 4, the processing procedure of FFR signal processing module 922 is: measure screening module 9221 and do not meet the measurement data that imposes a condition for rejecting each test section, impose a condition and to set according to actual tests, the embodiment of the invention impose a condition for: the maximum of the FFR digital signal that measures or minima hard ware measure equipment range (for example voltage saturation value of A/D capture card or bioelectric amplifier) 95% beyond reject, and remaining signal sends to signal de-noising module 9222 after will rejecting, signal de-noising module 9222 is carried out respectively Wiener filtering with the FFR digital signal of each test section that the experimenter tests, coherence average and bandpass filtering treatment, and the signal after will processing sends to signal-to-noise ratio (SNR) estimation module 9223; Signal-to-noise ratio (SNR) estimation module 9223 is calculated the signal to noise ratio of FFR digital signal, and the signal-to-noise ratio settings signal to noise ratio screening conditions according to calculating FFR digital signal, and the signal to noise ratio screening conditions are sent to data selection module 9224, data selection module 9224 is rejected the excessively low FFR signal of signal to noise ratio according to above-mentioned signal to noise ratio screening conditions; Wherein, signal-to-noise ratio (SNR) estimation module 9223 can be to noise reduction process when setting the signal to noise ratio screening conditions after the FFR digital signal of the certain-length (for example 133.6ms is long) that obtains of intercepting carry out spectrum analysis, adopt square estimation as signal energy of the highest spectrum peak-to-peak amplitude of its frequency spectrum, with between the free transmission range 70～210Hz of bandpass filtering except maximum spectrum peak the mean square value of other frequency spectrum amplitude as the screening conditions of noise ratio.
Noise in the FFR signal that FFR signals collecting logging modle 921 gathers comprises the non-corresponding composition that stimulates acoustic response in experimenter's brain electricity composition, hardware device of the present invention and frequency are followed the response signal test platform and are coupled to outside electromagnetic interference in the measuring circuit, and hardware device of the present invention and frequency are followed random noise of response signal test platform etc.Therefore after the 9221 measurement screenings of measurement screening module are finished, need to carry out respectively signal de-noising to the FFR signal of each test section of experimenter, comprise Wiener filtering, coherence average and bandpass filtering, then the signal with all test sections averages, wherein, the specific works principle of Wiener filtering:
The signal of certain test section is expressed as x through remaining measuring-signal after measuring 9221 rejectings of screening module
i(n), i=1 ~ N, N is the number of times of the repeated measure that is retained in this test section, and n counts for each signal of measuring, and corresponding to the duration of signal, then this measuring-signal is:
In the formula,
Be the i time signal component in the measuring-signal,
Be the i time noise contribution in the measuring-signal.
Signal x to all single measurements
i(n) power spectrum P
iAverage, can obtain the estimation to the power spectrum sum of the power spectrum of signal component and noise contribution, use
Expression:
In the formula, P
sThe power spectrum of expression signal component, P
nThe power spectrum of expression noise contribution, P
iThe power spectrum that represents the signal that measures for the i time.
It is folded average that the signal of measuring for all N time is carried out time domain:
Be the definitiveness composition according to signal component, noise contribution is the hypothesis of stationary random process, and after superposed average, the power spectrum of signal component is constant, and the power spectrum of noise contribution then is reduced into original N/one, namely
Power spectrum
For,
Above-mentioned formula (2) and (4) two formula simultaneous can be solved the power spectrum of signal component and noise contribution.According to the theory of Wiener filtering, under the condition that aforementioned hypothesis is set up, the signal that N measuring-signal superposed average obtained
Be the signal that obtains by behind the wave filter with amplitude-frequency response H (w) as shown in Equation (5), be the optimal estimation to aforementioned deterministic signal composition.
The various embodiments described above only are used for explanation the present invention; wherein the structure of each detection system and connected mode etc. all can change to some extent; every equivalents and improvement of carrying out on the basis of technical solution of the present invention all should do not got rid of outside protection scope of the present invention.
Claims (5)
1. a frequency is followed the response signal test macro, it is characterized in that: it comprises computer, D/A capture card, multichannel A/D capture card, acoustic sensor, preamplifier, body surface CD electrode, high input-impedance stage, bioelectric amplifier and earplug, and described acoustic sensor comprises Microspeaker and mini microphone; Described computer connects described D/A capture card and multichannel A/D capture card by the corresponding data interface, the input of described Microspeaker is connected with the outfan of described D/A capture card, the outfan of described Microspeaker is plugged in the described earplug by sound pipe, the input of described mini microphone is plugged in the described earplug by the transmission sound pipe, and the outfan of described mini microphone is connected with the input of described multichannel A/D capture card by described preamplifier; Described body surface CD electrode comprises the recording electrode that is arranged on subject's head, be arranged on the reference electrode at experimenter's ear ear-lobe mastoid process place of earplug homonymy and be arranged on the ground electrode at experimenter's place between the eyebrows place, described recording electrode, reference electrode and ground electrode are connected outfan and are connected with the input of described high input-impedance stage respectively, and the outfan of described high input-impedance stage is connected by the input of described bioelectric amplifier with described multichannel A/D capture card;
Frequency is set in the described computer follows the response signal test platform, described frequency is followed the response signal test platform and is comprised that test parameter arranges module, test signal generation module, test signal stimulating module, auditory meatus acoustic pressure monitoring modular and frequency and follows response signal extraction detection module; Described test parameter arranges frequency and the intensity that module is used for arranging stimulation sound, described test signal generation module generates corresponding digital stimulus signal according to the stimulation sound parameter that arranges, and send it to described test signal stimulating module, described test signal stimulating module sends digital stimulus signal to described D/A capture card, described D/A capture card converts digital stimulus signal to the aanalogvoltage stimulus signal, and the aanalogvoltage stimulus signal sent to described Microspeaker, described Microspeaker is converted to stimulus signal with the aanalogvoltage stimulus signal, and the sound stimulus signal sent in people's ear by described earplug, described auditory meatus acoustic pressure monitoring modular and frequency are followed response signal extraction detection module and simultaneously signal are gathered, described auditory meatus acoustic pressure monitoring modular is used for gathering and the interior sound pressure signal of record auditory meatus, and the sound pressure signal that gathers is carried out off-line analysis process, the sound pressure signal and the predefined judgment criterion that are about to gather compare, rejecting does not meet the signal segment of the normal acoustic pressure of auditory meatus, described frequency is followed response signal and is extracted detection module for gathering the FFR signal, and the FFR signal that gathers is carried out off-line analysis process, namely the corresponding FFR signal of the signal segment of the normal acoustic pressure of auditory meatus is carried out prescreen and processing, finish extraction and the demonstration of experimenter FFR signal.
2. a kind of frequency as claimed in claim 1 is followed the response signal test macro, it is characterized in that: described auditory meatus acoustic pressure monitoring modular comprises that auditory meatus acoustic pressure acquisition module, auditory meatus acoustic pressure logging modle, auditory meatus acoustic pressure judge module, auditory meatus acoustic pressure reject module and display module as a result; Described mini microphone carries out the acoustical signal in the auditory meatus that receives to send to described preamplifier after the acoustic-electric conversion, described preamplifier amplifies signal and it is sent to described auditory meatus acoustic pressure acquisition module through described multichannel A/D capture card, described auditory meatus acoustic pressure acquisition module sends signal to described auditory meatus acoustic pressure logging modle, described auditory meatus acoustic pressure logging modle is used for the sound pressure level that record collects, and send it to described auditory meatus acoustic pressure judge module, described auditory meatus acoustic pressure judge module and auditory meatus acoustic pressure are rejected module sound pressure signal are carried out the off-line analysis processing, be specially: described auditory meatus acoustic pressure judge module is judged the sound pressure level that gathers according to predefined judgment criterion, and judged result is sent to described auditory meatus acoustic pressure reject module, the sound pressure signal that described auditory meatus acoustic pressure rejecting module will satisfy described judgment criterion is rejected, and remaining sound pressure signal sends to described as a result display module demonstration after will rejecting.
3. a kind of frequency as claimed in claim 2 is followed the response signal test macro, it is characterized in that: described judgment criterion need to satisfy following three conditions simultaneously: the maximum of the sound pressure signal that 1) collects and the difference of minima adopt outside the scope of the difference that stimulates theoretical acoustic pressure maximum corresponding to sound intensity ± 6dB SPL and minima; The maximum of the sound pressure signal that 2) collects is greater than acoustic pressure maximum corresponding to adopt stimulation sound intensity+6dB SPL; 3) sound pressure signal is equally divided into five sections by acquisition time in the auditory meatus that will be recorded in the time of will sending stimulation sound, the maximum of a certain section sound pressure signal is peaked 75% less than five sections whole acoustic pressures, and perhaps the minima of a certain section sound pressure signal is greater than 75% of five sections whole acoustic pressure minima.
4. follow the response signal test macro such as claim 1 or 2 or 3 described a kind of frequencies, it is characterized in that: described frequency is followed response signal and is extracted detection module and comprise FFR signals collecting logging modle, FFR signal processing module and display module as a result; The recording electrode of described body surface CD electrode, reference electrode and ground electrode are surveyed the FFR signal of subject's head, and send it to described high input-impedance stage and obtain the FFR voltage signal, described high input-impedance stage sends to described bioelectric amplifier with the FFR voltage signal and carries out filtering, processing and amplifying, and the FFR voltage signal behind the filter and amplification sent to described multichannel A/D capture card, described multichannel A/D capture card is converted to the FFR digital signal with the FFR voltage signal and sends to described FFR signals collecting logging modle, described FFR signals collecting logging modle sends to described FFR signal processing module with the FFR digital signal, described FFR signal processing module carries out off-line analysis to the FFR digital signal data to be processed, obtain experimenter's FFR signal, and the FFR signal that extracts is sent to described as a result display module demonstration.
5. a kind of frequency as claimed in claim 4 is followed the response signal test macro, it is characterized in that: described FFR signal processing module comprises measures screening module, signal de-noising module, signal-to-noise ratio (SNR) estimation module and data selection module; Described measurement screening module is used for rejecting each test section and does not meet the measurement data that imposes a condition, and remaining signal sends to described signal de-noising module after will rejecting, described signal de-noising module is carried out respectively Wiener filtering, coherence average and bandpass filtering treatment with the FFR digital signal of each test section that the experimenter tests, and the signal after will processing sends to described signal-to-noise ratio (SNR) estimation module; Described signal-to-noise ratio (SNR) estimation module is calculated the signal to noise ratio of FFR digital signal, and the signal-to-noise ratio settings signal to noise ratio screening conditions according to the FFR digital signal that calculates, and described signal to noise ratio screening conditions are sent to described data selection module, described data selection module is rejected the excessively low FFR signal of signal to noise ratio according to described signal to noise ratio screening conditions.
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103800005A (en) * | 2014-02-17 | 2014-05-21 | 北京大学 | Device for evoking brain stem frequency following reaction through electrical stimulation and verification method |
| CN104535860A (en) * | 2014-12-22 | 2015-04-22 | 复旦大学 | Double-probe low-noise testing method for ultrafast transient electric response signals |
| CN104783807A (en) * | 2014-01-22 | 2015-07-22 | 蓝天翔 | Tinnitus acoustic data detection device and detection method |
| CN105310684A (en) * | 2014-07-28 | 2016-02-10 | 三星电子株式会社 | Apparatus and method for processing signal |
| CN106714063A (en) * | 2016-12-16 | 2017-05-24 | 深圳信息职业技术学院 | Beam forming method and system of microphone voice signals of hearing aid device, and hearing aid device |
| CN107510451A (en) * | 2017-08-07 | 2017-12-26 | 清华大学深圳研究生院 | A kind of pitch perception objective evaluation method based on brainstem auditory evoked potential,BAEP |
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| WO2019137079A1 (en) * | 2018-01-11 | 2019-07-18 | 清华大学 | Auditory sensitivity detection system based on stimulus-frequency otoacoustic emissions |
| CN110794273A (en) * | 2019-11-19 | 2020-02-14 | 哈尔滨理工大学 | Potential time domain spectrum testing system with high-voltage driving protection electrode |
| CN110858769A (en) * | 2018-08-24 | 2020-03-03 | 瑞昱半导体股份有限公司 | Receiver circuit |
| CN110958020A (en) * | 2018-09-26 | 2020-04-03 | 亚德诺半导体无限责任公司 | Auxiliary input of analog-to-digital converter input charge |
| CN110960224A (en) * | 2019-12-31 | 2020-04-07 | 杭州耳青聪科技有限公司 | Hearing threshold and/or hearing status detection systems and methods |
| CN111227842A (en) * | 2019-12-05 | 2020-06-05 | 北京市医疗器械检验所 | Method for measuring time characteristics of otoacoustic impedance/admittance instrument |
| CN112911995A (en) * | 2018-10-25 | 2021-06-04 | 株式会社三角工具加工 | Biological signal measuring device, biological state estimating device, and biological state estimating system |
| WO2021174961A1 (en) * | 2020-03-06 | 2021-09-10 | 宁波飞芯电子科技有限公司 | Array-type sensor chip and data output method therefor |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010034493A1 (en) * | 2000-02-14 | 2001-10-25 | Stone Robert T. | Multi-mode audiometric device and associated screening method |
| US6475163B1 (en) * | 2000-01-07 | 2002-11-05 | Natus Medical, Inc | Hearing evaluation device with patient connection evaluation capabilities |
| CN101690664A (en) * | 2009-10-23 | 2010-04-07 | 清华大学 | Comprehensive detection platform for auditory indexes of auditory system transmission access |
| US20120209139A1 (en) * | 2002-02-08 | 2012-08-16 | Michael Sasha John | Rapid screening, threshold, and diagnostic tests for evaluation of hearing. |
-
2012
- 2012-10-30 CN CN201210422599.9A patent/CN102973277B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6475163B1 (en) * | 2000-01-07 | 2002-11-05 | Natus Medical, Inc | Hearing evaluation device with patient connection evaluation capabilities |
| US20010034493A1 (en) * | 2000-02-14 | 2001-10-25 | Stone Robert T. | Multi-mode audiometric device and associated screening method |
| US20120209139A1 (en) * | 2002-02-08 | 2012-08-16 | Michael Sasha John | Rapid screening, threshold, and diagnostic tests for evaluation of hearing. |
| CN101690664A (en) * | 2009-10-23 | 2010-04-07 | 清华大学 | Comprehensive detection platform for auditory indexes of auditory system transmission access |
Non-Patent Citations (3)
| Title |
|---|
| MANUEL DON,ET AL: "Evaluating residual background noise in human auditory brain-stem responses", 《ACOUSTICAL SOCIETY OF AMERICA》 * |
| 宫琴，ET AL: "听觉系统传输通路综合检测平台的研制", 《仪器仪表学报》 * |
| 宫琴，ET AL: "瞬态诱发耳声发射信号的检测、分析及应用", 《航天医学与医学工程》 * |
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