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Numéro de publicationCN102989089 A
Type de publicationDemande
Numéro de demandeCN 201210585888
Date de publication27 mars 2013
Date de dépôt28 déc. 2012
Date de priorité28 déc. 2012
Numéro de publication201210585888.0, CN 102989089 A, CN 102989089A, CN 201210585888, CN-A-102989089, CN102989089 A, CN102989089A, CN201210585888, CN201210585888.0
Inventeurs黄昶荃, 李永红, 彭小东, 汪辉, 刘清秀, 刘良, 陶蓉
Déposant成都信息工程学院
Exporter la citationBiBTeX, EndNote, RefMan
Liens externes:  SIPO, Espacenet
Ultrasonic focusing device for treating Parkinson's disease
CN 102989089 A
Résumé
The invention discloses an ultrasonic focusing device for treating a Parkinson's disease. The ultrasonic focusing device is formed by a magnetic resonance scanning device, an ultrasonic transmitting device, an ultrasonic information setting device, an ultrasonic development device, a magnetic resonance information converting device and an magnetic resonance image display system. The magnetic resonance scanning device is connected with the magnetic resonance information converting device, the magnetic resonance image display system and the ultrasonic information setting device, and the ultrasonic information setting device is connected with the ultrasonic transmitting device and the ultrasonic development device. The ultrasonic focusing device utilizes functional magnetic resonance to position brain structures and is accurate in positioning.
Revendications(2)  Langue du texte original : Chinois
1. 一种治疗帕金森综合症的超声聚焦设备,其特征在于,由磁共振扫描装置、超声发射装置、超声信息设置装置、超声显像装置、磁共振信息转化装置和磁共振图像显示系统构成,磁共振扫描装置与磁共振信息转化装置连接,磁共振扫描装置与磁共振图像显示系统和超声信息设置装置连接,超声信息设置装置与超声发射装置和超声显像装置连接。 1. A method of treating Parkinson's disease ultrasound focusing device, characterized in that, by magnetic resonance imaging, ultrasound transmitting means, the ultrasound information setting apparatus, ultrasound imaging apparatus, a magnetic resonance apparatus and a magnetic resonance information into an image display system constituted , MRI and MRI scanning device information into a device is connected, MRI and MRI scanning device and image display system information setting device is connected ultrasound, the ultrasound device is connected to the information set launchers and ultrasound imaging ultrasound device.
2.根据权利要求1所述的治疗帕金森综合症的超声聚焦设备,其特征在于,所述超声发射装置2的数量为3个。 The treatment of Parkinson's disease focused ultrasound apparatus according to claim 1, characterized in that the ultrasound transmitter device 2 is the number 3.
Description  Langue du texte original : Chinois

一种治疗帕金森综合症的超声聚焦设备 A treatment for Parkinson's disease focused ultrasound equipment

技术领域 FIELD

[0001] 本发明属于医疗设备技术领域,涉及一种治疗帕金森综合症的超声共聚焦设备。 [0001] The present invention belongs to the technical field of medical equipment, relates to a method of treating Parkinson's disease confocal ultrasound equipment. 背景技术 BACKGROUND

[0002] 帕金森病(PD)是一种渐进性的神经系统退行性疾病,其特征是运动迟缓,僵直,休息时颤抖,躯干前驱倾向和站立不稳。 [0002] Parkinson's disease (PD) is a progressive degenerative disease of the nervous system, characterized by bradykinesia, rigidity, tremor at rest, torso precursor tendencies and unstable.

[0003] 临床采用外科脑内植入深部脑刺激(deep brain stimulation, DBS,俗称:脑起博器)增强黒质兴奋性,提高DA活性。 [0003] The clinical use of surgical implantation of deep brain stimulation in the brain (deep brain stimulation, DBS, commonly known as: brain pacemakers) enhanced quality black excitability, increase DA activity. 目前由于核磁共振成像MRI和(电子计算机X射线断层扫描技术)可以精确定位大脑各神经核团(包括黒质和纹状体。近年来由于分子影像学的发展,可对核团内部分神经细胞进行功能现象。除深部脑起博器外,近年来逐渐兴起的射频热凝毁损治疗是脑立体定向手术的治疗重要治疗方法,用于ro的治疗。另外,经颅电刺激等治疗已用于F1D治疗,但疗效不确切。 At present, because MRI and magnetic resonance imaging (X-ray computer tomography) can pinpoint each nucleus of the brain (including the black substance and striatum in recent years due to the development of molecular imaging can be part of the nerve cells in the nuclei functional phenomenon. In addition to deep brain pacemaker, but in recent years, the gradual rise of radiofrequency ablation in the Treatment of brain stereotactic surgery is an important therapeutic treatment method for the treatment of ro. In addition, transcranial electrical stimulation therapy has been used F1D treatment, but the effects are imprecise.

[0004] 脑起博器存在以下不足:在脑内核团植入微电极来改善症状,术后可能发生脑出血和脑水肿,部分患者术后一段时间内症状复发;有严重心肺肾疾病、难以控制的高血压和有精神症状的患者不宜运用;另外费用昂贵,目前单侧治疗约需10多万元,双侧治疗约需20多万元,需要定期更换电池,所需费用较高,一般患者常难以承受;同时易出现设备故障。 [0004] brain pacemakers following deficiencies: the core group in the brain microelectrodes implanted to improve symptoms, may occur after cerebral hemorrhage and cerebral edema, after a period of time to recurrence of symptoms in some patients; severe heart, lung and kidney disease, it is difficult hypertension and psychiatric symptoms in patients control should not be used; in addition expensive treatment is currently about 10 million unilateral, bilateral treatment of about 20 million, require periodic battery replacement, required higher cost, general Patients often unbearable; also prone to equipment failure.

[0005] 高强度聚焦超声作为一种新的肿瘤治疗手段使得一些失去手术机会年老体弱失去放、化疗机会的肿瘤病人提供了治疗可能,并且得到了广泛的认可。 [0005] The high-intensity focused ultrasound tumor therapy as a new means of making some unresectable put frail lose, cancer patients receiving chemotherapy treatment may provide opportunities, and has been widely recognized. 超声聚焦就是利用超声波作为能源。 Focused ultrasound is the use of ultrasound as an energy source. 很多束超声波从体外发射到身体里去,在发射透射过程中间发生聚焦,聚焦在一个点即肿瘤上,通过声波和热能转化,在0. 5〜I秒内形成一个70°C〜100°C高温治疗点,这个高温点好比是一个手术刀在切割肿瘤,焦点区的肿瘤无一幸免。 Many ultrasonic beam emitted from outside the body to go, the focus occurs in the middle of transmitting a transmission process, a point that is focused on the tumor, by sonic and thermal energy conversion, within 0. 5~I seconds to form a 70 ° C~100 ° C hyperthermia point, the hot spots is like a scalpel cutting the tumor, the tumor focus areas spared. 超声聚焦刀使肿瘤组织产生凝固性坏死,失去增殖、浸润和转移能力。 Focused ultrasound tumor tissue coagulation necrosis, loss of proliferation, invasion and metastasis. 此机原理类似于太阳灶聚阳光于焦点处产生巨大能量。 This machine works like a solar cooker gather sunlight to generate tremendous energy in focus. 因此,应用MRI分子影像学技术,应用高强度聚焦超声破坏适量Ach神经元细胞,使其活性降低,使黒质-纹状体的DA和Ach达到新的平衡,临床治愈是临床可以选择的途径。 Therefore, the application of MRI molecular imaging technology, the application of high intensity focused ultrasound destroy the right amount of Ach neurons, its activity decreases, so that black mass - striatal DA and Ach reach a new equilibrium, clinical cure is clinical pathways can choose .

[0006] 射频热凝毁损治疗:通过高频率电磁波,破坏纹状体的胆碱能神经元治疗H)。 [0006] Radiofrequency ablation in the Treatment: The high-frequency electromagnetic waves, the destruction of cholinergic neurons in the striatum of treatment H). 该方案克服了脑起博器的术后可能发生脑出血和脑水肿;有严重心肺肾疾病、难以控制的高血压和有精神症状的患者不宜运用;另外,费用昂贵和设备故障的缺陷。 The program overcomes the postoperative brain pacemakers may occur cerebral hemorrhage and cerebral edema; severe heart, lung and kidney disease, hypertension and psychiatric symptoms in patients with difficult to control inappropriate use; in addition, the cost of expensive equipment failure and defects. 射频热凝毁损治疗缺点:破坏范围难局限在很小范围(100微米左右),可能损伤周围神经结构,导致重要功能异常。 Radiofrequency ablation in the Treatment Disadvantages: damage limited to a small range of difficulty range (100 microns), the structure of peripheral nerve damage may lead significant dysfunction.

发明内容 SUMMARY

[0007] 为了解决上述技术问题,本发明提供一种治疗效果显著、副作用小,成本低的治疗帕金森综合症的超声聚焦设备,其技术方案如下: [0007] In order to solve the above problems, the present invention provides a significant treatment effect, side effects, and low cost of the treatment of Parkinson's syndrome focused ultrasound equipment, its technical programs are as follows:

[0008] 一种治疗帕金森综合症的超声聚焦设备,由磁共振扫描装置1、超声发射装置2、超声信息设置装置3、超声显像装置4、磁共振信息转化装置5和磁共振图像显示系统6构成。 [0008] A method for treating Parkinson's disease focused ultrasound equipment, MRI scanning device by an ultrasonic transmitter device 2, ultrasound information setting device 3, ultrasound imaging device 4, 5, and magnetic resonance imaging MRI information into the display device System 6 constitution. 磁共振扫描装置I与磁共振信息转化装置5连接,磁共振扫描装置I与磁共振图像显示系统6和超声信息设置装置3连接,超声信息设置装置3与超声发射装置2和超声显像装置4连接。 MRI and MRI scanning device I connect information into device 5, MRI and MRI scanning device I 6 and the ultrasound image display system information setting device 3, ultrasound device information setting means 2 and 3 ultrasound imaging and ultrasound transmitter device 4 connection.

[0009] 进一步优选,所述超声发射装置2的数量为3个。 [0009] Further preferably, the number of ultrasound transmitter device 2 is three.

[0010] 本发明所述设备的原理为:帕金森发病机制是由于神经系统老化导致黒质纹状体多巴胺神经元分泌多巴胺递质减少,胆碱能神经元活性相对增强。 [0010] the principle of the apparatus of the present invention are: the pathogenesis of Parkinson's is caused by the aging of the nervous system due to black nigrostriatal dopamine neurotransmitter dopamine neurons decreased cholinergic neuronal activity relative enhancement. 目前临床治疗帕金森主要手段是补充多巴胺、激活多巴胺神经元活性、拮抗乙酰胆碱活性治疗。 At present, the clinical treatment of Parkinson's primary means of supplementing the dopamine, activate dopamine neuronal activity, antagonize the activity of acetylcholine treatment. 本设备原理:用功能磁共振定位胆碱能神经元,用超声共聚焦可精确定位和破坏100微米左右结构特性,破坏胆碱能神经元,从而减少黒质纹状体区域的胆碱能递质,从而治疗H)。 This device works: neurons with functional magnetic resonance positioning choline, confocal ultrasound can be used to pinpoint and destroy the structural properties of about 100 microns, the destruction of cholinergic neurons, thereby reducing the black nigrostriatal region cholinergic delivery mass, thereby treating H).

[0011] 与现有技术相比,本发明的有益效果:该设备首次利用超声共聚焦可破坏单个体积较大细胞的特性,破坏黒质纹状体胆碱能神经元,治疗帕金森病。 [0011] Compared with the prior art, the beneficial effects of the present invention: the use of the device for the first time confocal ultrasound can damage cells characteristic of a single larger, black mass destruction of cholinergic neurons in the striatum, the treatment of Parkinson's disease. 首次从破话黒质纹状体胆碱能神经元着手,治疗帕金森病。 For the first time, then break Black nigrostriatal cholinergic neurons begin, the treatment of Parkinson's disease. 首次利用超声共聚焦,聚焦范围精确特点,破坏单个神经元。 The first use of ultrasound scanning confocal, focus range precision characteristics, destruction of individual neurons. 该设备填补了国内外无用破坏脑黒质纹状体系统胆碱能神经元专门治疗ro的空白,与手术治疗ro相比可减少开颅手术的各种并发症,同时可及时后效评估,多次治疗,达到治疗目的的效果。 The device is useless at home and abroad to fill the gaps black nigrostriatal system damage brain cholinergic neurons specialized treatment ro and ro and surgical treatment can reduce complications compared craniotomy, while aftereffect timely assessment, multiple treatments to achieve the effect of therapeutic purposes. 与药物治疗相比可避免长期服药带来的不变,及药物的副作用(作用于体内其他胆碱能神经元的作用)。 Compared with drug treatment can prevent long-term medication to bring change, and drug side effects (effects acting on the body other cholinergic neurons). 因此该设备同现有治疗手段相比具有安全、方便、可行、副作用小,同时比手术治疗和长期药物治疗更经济。 Therefore, the device compared with existing therapies is safe, convenient and feasible, side effects, and more economical than surgery and long-term drug treatment. 主要表现以下方面: Mainly the following aspects:

[0012] (I)利用功能磁共振对脑结构定位,定位准确; [0012] (I) using functional magnetic resonance imaging of brain structure positioning, accurate positioning;

[0013] (2)可精确破坏黒质纹状体区域的胆碱能神经元,从而减少乙酰胆碱的分泌; [0013] (2) can be accurately destroy choline Black nigrostriatal neurons in the region, thereby reducing the secretion of acetylcholine;

[0014] (3)同深部脑电磁技术治疗ro比较不需开颅手术; [0014] (3) with deep brain electromagnetic technology without treatment ro compare craniotomy;

[0015] (3)可控性好,治疗后评估,可反复多次治疗,直到达到治疗目的。 [0015] (3) controllable, after treatment, assessment, treatment can be repeated several times, until it reaches therapeutic purposes.

附图说明 Brief Description

[0016] 图1是本发明治疗帕金森综合症的超声共聚焦设备的结构图。 [0016] The present invention Figure 1 is the treatment of Parkinson's syndrome diagram confocal ultrasound equipment.

具体实施方式 DETAILED DESCRIPTION

[0017] 下面结合附图和具体实施方式对本发明的技术方案作进一步详细地说明。 [0017] below with reference to the drawings and detailed description of the aspect of the present invention will be described in more detail.

[0018] 参照图1,一种治疗帕金森综合症的超声聚焦设备,由磁共振扫描装置1、超声发射装置2、超声信息设置装置3、超声显像装置4、磁共振信息转化装置5和磁共振图像显示系统6构成,磁共振扫描装置I与磁共振信息转化装置5连接,磁共振扫描装置I与磁共振图像显示系统6和超声信息设置装置3连接,超声信息设置装置3与超声发射装置2和超声显像装置4连接。 [0018] Referring to Figure 1, a 3, ultrasound imaging apparatus 4, the information conversion unit 5 and the magnetic resonance treatment of Parkinson's syndrome ultrasound focusing device, by magnetic resonance imaging apparatus 1, the ultrasound transmitter device 2, ultrasound information setting means Magnetic resonance image display system 6 forms, MRI and MRI scanning device I connect information into device 5, MRI and MRI scanning device I display system information setting means 6 and ultrasound 3 connection, ultrasound information setting means 3 and the ultrasound transmitter 4 connecting device 2 and ultrasound imaging devices. 磁共振扫描装置I与磁共振信息转化装置5连接,磁共振扫描装置I与磁共振图像显示系统6和超声信息设置装置3连接,超声信息设置装置3与超声发射装置2和超声显像装置4连接。 MRI and MRI scanning device I connect information into device 5, MRI and MRI scanning device I 6 and the ultrasound image display system information setting device 3, ultrasound device information setting means 2 and 3 ultrasound imaging and ultrasound transmitter device 4 connection. 所述超声发射装置2的数量为3个。 The ultrasound transmitter device 2 is the number 3.

[0019] 本发明所述设备在使用时,磁共振扫描装置I扫描,将扫描的信息传送到磁共振信息转化装置5,磁共振信息转化5将扫磁共振扫描装置I扫描的信息进行转换,扫描的信息同时传到超声信息设置装置3,超声信息设置装置3将此次信息传到显示传到超声显像装置4,超声信息设置装置3整合来自于磁共振信息转化装置5的信息,并设置超声共聚焦所在位置,并将此位置显示在超声显像装置4上,装置3根据来自5的信息设置共聚焦位置,并传送到装置2,2发出超声毁损显示神经元。 [0019] The apparatus of the present invention is in use, the MRI scanning means I, to transfer information to the magnetic resonance scanning information conversion means 5, 5 MR information into the MRI apparatus I sweep scanning information conversion, ultrasound scanning information simultaneously transmitted information setting means 3, ultrasound information setting means 3 the information on to the transmitted ultrasound imaging display device 4, ultrasonic information setting means 3 for integrating information from a magnetic resonance information conversion device 5, and Set ultrasonic confocal location, and this position is displayed on the ultrasound imaging apparatus 4, based on information from the setting device 3 5 confocal position, and transmitted to the display device 2, 2 emitted ultrasound damaged neurons. 配合功能磁共振显示大脑黒质纹状体胆碱能神经元,通过磁共振信息转化装置5处理信息,将目标图像显示在磁共振图像显示系统6上。 Black with functional magnetic resonance imaging of the brain mass display of cholinergic neurons in the striatum, by magnetic resonance information processing information conversion unit 5, the target image is displayed on the system in a magnetic resonance image 6.

[0020] 该设备主要用超声共聚焦形成高温可破坏人体内组织结构。 [0020] The device is mainly used for the formation of high-temperature confocal ultrasound can damage human tissue structures in vivo. 目前超声共聚焦治疗肿瘤技术成熟,临床广泛应用。 Currently confocal ultrasound tumor therapy technology is mature, widely used clinically. 但超声共聚焦治疗肿瘤,一般聚焦范围大,破坏肿瘤组织的体积较大。 However, confocal ultrasound treatment of cancer, a large general focus range, larger tumor tissue destruction. 在该装置中超声破坏细胞为神经元细胞,神经细胞直径100 i! m左右,因此,该装置中对共聚焦的精度定在lOOym。 In this device, ultrasound damage cells into neurons, nerve cells in diameter 100 i! M or so, so that the device on the accuracy of confocal set at lOOym. 目前对帕金森病治疗采用补充多巴胺、激活黒质纹状体多巴胺神经元、胆碱能拮抗药物治疗。 At present, the use of supplements for the treatment of Parkinson's disease dopamine, activate Black nigrostriatal dopaminergic neurons, cholinergic antagonism medication. 该装置是目前唯一精确破坏黒质纹状体胆碱能神经元治疗设备,该装置使用目前功能磁共振可以对大脑神经元功能现象,精确显示黒质纹状体神经元。 The device is currently the only accurate black mass destruction of cholinergic neurons in the striatum therapy device, the device is currently using functional magnetic resonance brain neurons can function phenomena accurately display black nigrostriatal neurons. 黒质纹状体胆碱能神经元直径在100 ym,在超声共聚焦精确范围内,理论可行。 Black nigrostriatal cholinergic neurons in diameter 100 ym, confocal ultrasound within the accuracy of the theory is feasible.

[0021] 该设备为一治疗ro的专有设备,该设备包含功能磁共振功能和超声共聚焦功能,利用功能磁共振准确定位黒质纹状体胆碱能神经元,用超声共聚焦设备科精确定位,小范围聚焦形成高位破坏组织结构。 [0021] The device is a treatment ro proprietary device that contains a functional magnetic resonance imaging and ultrasound capabilities confocal functionality, using functional magnetic resonance imaging to accurately locate black mass of cholinergic neurons in the striatum, using ultrasound scanning confocal Equipment Division precise positioning, small-scale destruction of the organizational structure of the high focus formation. 该设备治疗ro同胆碱能拮抗剂(安坦、苯海索等)具有共同靶点,和同样机理;但该设备治疗疗效更显著,避免长期服药的不便和对其他组织器官的副作用。 The device treatment ro with cholinergic antagonists (Antin, trihexyphenidyl, etc.) have a common target, and the same mechanism; but the device therapy more significant, long-term medication to avoid the inconvenience and side effects to other tissues and organs.

[0022] 以上所述,仅为本发明最佳实施方式,任何熟悉本技术领域的技术人员在本发明披露的技术范围内,可显而易见地得到的技术方案的简单变化或等效替换均落入本发明的保护范围内。 [0022] The above are only preferred embodiments of the present invention, a simple variation of any skilled in the art in the art within the technical scope disclosed in the present invention, may be apparent that the resulting aspect or equivalents that fall within the scope of the invention.

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Classifications
Classification internationaleA61N7/00
Événements juridiques
DateCodeÉvénementDescription
27 mars 2013C06Publication
29 mai 2013C10Entry into substantive examination
25 févr. 2015C53Correction of patent for invention or patent application
25 févr. 2015CORChange of bibliographic data
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19 oct. 2016C02Deemed withdrawal of patent application after publication (patent law 2001)