CN103027742A - Nuclear magnetic resonance compatible cold-thermal therapy system - Google Patents
Nuclear magnetic resonance compatible cold-thermal therapy system Download PDFInfo
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- CN103027742A CN103027742A CN2012105905148A CN201210590514A CN103027742A CN 103027742 A CN103027742 A CN 103027742A CN 2012105905148 A CN2012105905148 A CN 2012105905148A CN 201210590514 A CN201210590514 A CN 201210590514A CN 103027742 A CN103027742 A CN 103027742A
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Abstract
The invention discloses a nuclear magnetic resonance compatible cold-thermal therapy system, which comprises a cold therapy module, a thermal therapy module, a heat insulated cold-thermal knife, a temperature sensor and a control module. The cold therapy module and the thermal therapy module are coordinated through a control module to work alternatively, the control module is used for collecting the temperature of focuses during a cold therapy process and the gas pressure in a circuit as well as controlling the flow of gas or liquid in the circuit, and the control module is further used for collecting the temperature of focuses during a thermal therapy process and controlling the heating power. According to a nuclear magnetic resonance cold-thermal therapy system, the growth and melting situations of an ice ball can be monitored in real time, and thus tumour cells can be accurately and rapidly killed.
Description
Technical field
The present invention relates to technical field of medical instruments, particularly the cold and hot treatment of a kind of nuclear magnetic resonance, NMR compatible type system.
Background technology
Tumor is one of disease that mortality rate is the highest in the world at present, and human life in serious threat.Yet oneself belonged to late period when 70%～80% patient made a definite diagnosis, and had lost the chance of operative treatment, yet even operative treatment, the probability of postoperative recurrence and transfer is still up to 50%～70%, total cure rate less than 10%.Thereby, accurately, rapidly, the kill tumor cell is extremely important neatly.
The method of traditional treatment tumor generally includes the methods such as excision, radiation and chemotherapy, and wherein, the operative treatment risk is high, and especially for the tumor of position sensitivity, such as the cerebral tumor, surgical risk is large, and success rate is low.And operation is large to the wound of human body, and patient's immunity is reduced, and to the resistance decline of disease, and easily produces a series of postoperative complication; Radiation and chemotherapy is when killing and wounding cancerous cell, also normal cell and immunity (opposing) cell are together killed, although can the part or whole body ameliorate tumor cell load by the radiation and chemotherapy method, but it can't eradicate tumor cell tissue, easily shift, recurrence, the whole body toxic and side effects is large, very easily produce and feel sick, vomiting, alopecia, the symptoms such as inappetence, cause the immune function of human body damage, increase the weight of conditions of patients, cancer patient's physical and mental health is caused heavy strike, especially Advanced Carcinoma Patient, its physical condition usually can't tolerate the huge side effect of chemotherapy, therefore a lot of patients with terminal are not suitable for the chemotherapeutic treatment method more, and particularly middle and advanced stage tumor or weakly patient use the chemotherapy and radiation method blindly, not only can cause the state of an illness to worsen rapidly, more can accelerate patient's death.
Though general argon helium knife can be realized freezing and the effect thermotherapy treatment tumor now, because the principle of its thermotherapy is to produce heat by helium when needle point discharges rapidly, and rewarming and intensification are rapidly, but the maximum temperature that its thermotherapy can reach is limited, there are data to show that traditional argon helium knife can only reach between 20 ℃～30 ℃ at temperature, it is generally acknowledged that the critical point of lethal temperature of most of malignant tumor cell is at 42.5～43 ℃, the minimum temperature of killing malignant cell is 42 ℃, and the duration of heat need to be more than half an hour; Temperature is higher, and it is just shorter to kill the needed time of cancerous cell, and therefore, general argon helium knife usually can't reach the needed temperature of kill cancer cell or other focuses zone now, can not play the effect of thermotherapy.
Summary of the invention
In order to solve above-mentioned problems of the prior art, the invention provides the cold and hot treatment of a kind of nuclear magnetic resonance, NMR compatible type system, this cold and hot treatment system is adapted at working under the guiding in real time of nmr imaging technique (MRI).
The cold and hot treatment of nuclear magnetic resonance, NMR compatible type provided by the invention system comprises:
Cold treatment module, it further comprises intake channel and the path of giving vent to anger, described intake channel is used for low-temperature receiver is guided to the point of a knife of the cold and hot cutter 5 of described heat insulation, and it comprises successively: be equipped with low-temperature receiver steel cylinder 1, be used for measuring the first air gauge 2, first valve 3 of the pressure of described steel cylinder 1; The described path of giving vent to anger is used for absorbing the waste gas that cold treatment process produces, and it comprises successively: the 3rd valve 7, the heater 8 that is used for the described path of giving vent to anger is heated, the second air gauge 10 that is used for measuring the pressure of the described path of giving vent to anger, mobile pump 11, the 4th valve 12 that power is provided that is used to low-temperature receiver, be used for the waste gas bottle 14 of the waste gas that accommodating therapeutic process produces;
The thermotherapy module, it comprises radio-frequency signal generator 16 and radio-frequency (RF) thermotherapeutic antenna, described radio-frequency signal generator 16 links to each other with described radio-frequency (RF) thermotherapeutic antenna with control module, for generation of rf wave; Described radio-frequency (RF) thermotherapeutic antenna runs through the cold and hot cutter 5 of whole heat insulation, and its end is connected with described radio-frequency signal generator 16 by rf signal line, and it places the top at the point of a knife place of the cold and hot cutter 5 of described heat insulation, is used for launching the rf wave that described radio-frequency signal generator 16 produces;
The cold and hot cutter 5 of the branched heat insulation that can control separately, be used for being inserted into pathological tissues and carry out cold and hot treatment, the knife bar inside of the cold and hot cutter 5 of each heat insulation includes an argon pipeline and a radio-frequency (RF) thermotherapeutic antenna, the argon pipeline is used for the high pressure argon is transported to the point of a knife place, the cold and hot cutter 5 of each heat insulation also is provided with the air inlet and the gas outlet that is connected the described path of giving vent to anger that connect described intake channel, and is used to cold treatment process that low-temperature receiver is provided and gets rid of the waste gas that produces in the cold treatment process;
Temperature sensor is installed in the point of a knife of the cold and hot cutter 5 of described heat insulation, and is connected with described control module, is used for the temperature of cold and hot cutter 5 points of a knife of the described heat insulation of Real-time Collection;
Control module, at least comprise one with described pump 11 be connected the computer 15 that radio-frequency signal generator 16 is connected, be used for the transmitting power of regulating flow and the described radio-frequency signal generator 16 of described pump 11 according to the signal that the parameter of setting in advance and described temperature sensor and the second air gauge 10 are passed back.
Compared with prior art, the cold and hot treatment advantage of system of nuclear magnetic resonance, NMR compatible type proposed by the invention is as follows:
1. can be by Medical Imaging Technology (MRI) Real Time Monitoring and guiding during this system works, thereby avoided dynamically to observe, organizational structure is unintelligible, resolution is not high, there is pseudo-shadow, the deficiencies such as radioactivity are arranged, make in whole treatment and the use procedure, the position of focus, the growth of ice hockey and the elimination situation that melts situation, focus can both obtain good Real Time Monitoring.
2. the thermotherapy process of this system heats up tumor tissues with helium in point of a knife release and compares by radio frequency heating, and radio frequency can be heated to higher temperature to tumor tissues, and temperature is higher, and it is just shorter to kill the cancerous cell required time.Further, because the wavelength ratio of radio frequency is larger, very strong to the penetration power of tissue, therefore, heat can be penetrated into deep tissue.
3. what the present invention adopted is a kind of mode of interventional minimally-invasive treatment, has its unique distinction, little such as wound, expense is low, recovery is fast, need not to be in hospital, with controlling with walking pure green remedy, have no side effect "dead" (interventional therapy is the process that a kind of accurate targeting destroys).
4. the cold and hot cutter of heat insulation that 4～8 models are different and can control separately is equipped with in the present invention, can be fit to treat different sizes, diverse location, the tumor of different times.
Description of drawings
Fig. 1 is the cold and hot treatment system schematic of nuclear magnetic resonance, NMR compatible type according to an embodiment of the invention.
Fig. 2 is the cold and hot treatment system schematic of nuclear magnetic resonance, NMR compatible type according to another embodiment of the present invention.
The specific embodiment
For making the purpose, technical solutions and advantages of the present invention clearer, below in conjunction with specific embodiment, and with reference to accompanying drawing, the present invention is described in more detail.
The present invention proposes the cold and hot treatment of a kind of nuclear magnetic resonance, NMR compatible type system, and this system comprises: the cold treatment module of cold and hot treatment system, thermotherapy module, the cold and hot cutter 5 of the branched heat insulation that can control separately, control module and sensor, wherein:
The cold treatment module of described cold and hot treatment system further comprises intake channel and the path of giving vent to anger, and described intake channel comprises successively: steel cylinder 1, the first air gauge 2, first valve 3 of low-temperature receiver are housed, are used for low-temperature receiver is guided to the point of a knife of the cold and hot cutter 5 of described heat insulation; Wherein, described low-temperature receiver is high pressure argon or cryogenic liquid (such as liquid nitrogen); Described the first air gauge 2 is used for measuring the pressure of described steel cylinder 1; The described path of giving vent to anger comprises successively: the 3rd valve 7, heater 8, effusion meter 9, the second air gauge 10, pump 11, the 4th valve 12, the 3rd air gauge 13, waste gas bottle 14 are used for absorbing the waste gas that cold treatment process produces; Wherein, described heater 8 is used for the described path of giving vent to anger is heated, with the pressure in the described path of giving vent to anger of auxiliary adjustment; Described effusion meter 9 is used for measuring the flow of the described path low-temperature receiver of giving vent to anger, and the operator can judge whether instrument works by the reading of effusion meter 9; Described the second air gauge 10 is used for measuring the pressure of the described path of giving vent to anger, and carries out Adjustment operation to offer described control module; The mobile power that provides of low-temperature receiver is provided described pump 11; Described the 3rd air gauge 13 is used for measuring the pressure of described waste gas bottle 14; Described waste gas bottle 14 is used for the waste gas that accommodating therapeutic process produces;
Described thermotherapy module comprises: radio-frequency signal generator 16 and the radio-frequency (RF) thermotherapeutic antenna that places the cold and hot cutter of described heat insulation 5 inside, and wherein, described radio-frequency signal generator 16 links to each other with described radio-frequency (RF) thermotherapeutic antenna with described control module; Described radio-frequency signal generator 16 is for generation of rf wave; The pole of described radio-frequency (RF) thermotherapeutic antenna for being made by conductive material, described radio-frequency (RF) thermotherapeutic antenna runs through the cold and hot cutter of whole heat insulation (such as the central shaft along the cold and hot cutter 5 of described heat insulation), the end of described radio-frequency (RF) thermotherapeutic antenna is connected on the described radio-frequency signal generator 16 by radio frequency line, its top, the point of a knife place of the cold and hot cutter 5 of described heat insulation namely, be used for launching the rf wave that described radio-frequency signal generator 16 produces, to excite point of a knife pathological tissues (referring generally to human canceration's tissue) on every side ion concussion frictional heat occur;
The cold and hot cutter 5 of described heat insulation is used for being inserted into pathological tissues and carries out cold and hot treatment, the knife bar inside of the cold and hot cutter 5 of each heat insulation comprises that (internal diameter is chosen as 0.3～1mm) and a described radio-frequency (RF) thermotherapeutic antenna to an argon pipeline, the argon pipeline causes cold and hot jet blade to the high pressure argon, the cold and hot cutter 5 of each heat insulation also is provided with an air inlet and gas outlet, wherein, described air inlet connects the intake channel in the cold treatment module of described cold and hot treatment system, thinks that cold treatment process provides low-temperature receiver; Described gas outlet connects the path of giving vent to anger in the cold treatment module of described cold and hot treatment system, to get rid of the waste gas that produces in the cold treatment process, also regulate simultaneously the pressure of the path of giving vent to anger that described gas outlet connects by described control module, come the flow of the low-temperature receiver of the cold and hot cutter 5 of the described heat insulation of indirectly control.The quantity of the cold and hot cutter 5 of described heat insulation is generally 4～8, and diameter is typically designed to 1～8mm, and wherein, the diameter of the cold and hot cutter 5 of described heat insulation and quantity can be decided according to concrete operating position.
In described cold and hot treatment system, the cold and hot cutter 5 of described heat insulation and coupled gas passage and described rf signal line are in the nuclear magnetic resonance, NMR district, so these parts need to be made with paramagnetic material.
Further, be embedded with the active adiabatic section based on thermal compensation on the knife bar of the cold and hot cutter 5 of described heat insulation, be frozen injury to avoid pathological tissues normal structure on every side.
Further, the present invention can be according to concrete kind, position, size and the residing different times of pathological tissues, select different cold and hot treatment schemes and the cutter of different model, in addition, in order to prevent that low-temperature receiver pressure is excessive and damage the cold and hot cutter of described heat insulation, can be connected to connect respectively an air relief valve with the gas outlet at the air inlet of the cold and hot cutter of described heat insulation, the first air relief valve 4 as shown in Fig. 1 and Fig. 2 and the second air relief valve 6.
Described sensor comprises pressure transducer (the second air gauge 10) and temperature sensor, wherein, described the second air gauge 10 is installed in the described path of giving vent to anger, and be connected with described control module, be used for gathering the pressure values of the described path of giving vent to anger, and described control module can be regulated according to the gas pressure intensity value that described the second air gauge 10 collects the pressure of the described path of giving vent to anger; Described temperature sensor is installed in the point of a knife of the cold and hot cutter 5 of described heat insulation, and be connected with described control module, the temperature that is used for cold and hot cutter 5 points of a knife of the described heat insulation of Real-time Collection, and the point of a knife real time temperature value that described control module can be passed back according to described temperature sensor is regulated the work of described cold and hot treatment system;
Described control module comprises a computer 15 at least, described computer 15 and described pump 11 be connected radio-frequency signal generator 16 and be connected, be used for the transmitting power of regulating flow and the described radio-frequency signal generator 16 of described pump 11 according to the signal that the parameter of setting in advance and described sensor are passed back.
In an embodiment of the present invention, this cold and hot treatment system adopts argon to freeze, and as shown in Figure 1, in the cold and hot treatment system that adopts that argon freezes, in the described steel cylinder 1 the high pressure argon is housed; In the described intake channel, after described the first valve 3, also be provided with a cryogenic liquid (such as liquid nitrogen) bottle 17 and 1 second valve 18, be used for carrying out pre-cooling from described steel cylinder 1 high pressure argon out.
During this system works, cold treatment process is to adopt the throttle effect (argon fast cooling technology) that produces that discharges rapidly of argon to lower the temperature, by the rapid expansion of argon in point of a knife inside, can be refrigerated in second below-100 ℃ at 30-60, namely freezing rate is 100-200 ℃/min.In cold treatment process, the pathological tissues around the cold and hot cutter point of a knife of described heat insulation is frozen rapidly icing, forms ice hockey, and along with the carrying out of cold treatment process, the volume of ice hockey constantly increases; The thermotherapy process adopts radio frequency (RF) to heat, wherein, rf frequency is 100kHz～100MHz, and is different from microwave, the wavelength of radio frequency is longer, thereby penetration power is stronger, and simultaneously, this ray has the dual-use function of heating and sensing, therefore, compare with microwave heat therapeutic, the radio-frequency (RF) thermotherapeutic scheme is so that the heat length of penetration in the tissue is large, and this is the most significant advantage of radio-frequency (RF) thermotherapeutic scheme.
Particularly, when using argon fast cooling technology to carry out cold treatment in this system, under the guiding of nuclear magnetic resonance, NMR, the cold and hot cutter 5 of described heat insulation is inserted into pathological tissues, in tumor, point of a knife is positioned on the central point of described pathological tissues; The first valve 3 is opened in described control module control, the second valve 18, the 3rd valve 7, the 4th valve 12, heater 8 and pump 11, carry out pre-cooling by cryogenic liquid bottle 17 first from described steel cylinder 1 high pressure argon out, then arrive the point of a knife of the cold and hot cutter 5 of described heat insulation through one section transfer tube, described high pressure argon is sprayed into the gas backstreaming chamber of the larger cold and hot cutter inside of volume ratio by the argon pipe end at the cutter head place, this moment, the pressure of argon was down to rapidly normal pressure, cooling class throttle effect occurs, so that the temperature of point of a knife descends rapidly, usually can be refrigerated in second below-100 ℃ at 30-60, namely freezing rate is 100-200 ℃/min; Simultaneously, the argon of backflow is drawn back to waste gas bottle 14 by pump 11.Wherein, the signal that described control module gathers according to described the second air gauge 10, the flow by regulating pump 11 and regulate pressure in the described cold treatment module heat time heating time of heater 8 is with the flow of argon in the described cold treatment module of indirectly control.Under the monitoring of nuclear magnetic resonance, NMR, when treating that ice hockey surrounds whole pathological tissues, stop cold treatment, this moment, the first valve 3, the second valve 18, the 3rd valve 7, the 4th valve 12, heater 8 and pump 11 were closed in described control module control.
When this system carries out thermotherapy, described radio-frequency signal generator 16 is opened in described control module control, the described radio-frequency (RF) thermotherapeutic antenna that is connected with described radio-frequency signal generator 16 sends the high-frequency radio frequency ripple, thereby excite the pathological tissues generation ion concussion heat production around the cold and hot cutter of described heat insulation, continuous rising along with pathological tissues self temperature, ice hockey melts gradually, and final so that ice hockey all melts.In the thermotherapy process, can determine the maximum temperature point that radio-frequency (RF) thermotherapeutic will be heated to according to kind and the different times of living in of pathological tissues.It is generally acknowledged the lethal temperature critical point of most of malignant tumor cell at 42.5～43 ℃, the minimum temperature of killing malignant cell is 42 ℃, and requires need more than half an hour the duration of heat.
In another embodiment of the present invention, this cold and hot treatment system adopts cryogenic liquid (such as liquid nitrogen) to freeze, and below describes as an example of liquid nitrogen example.As shown in Figure 2, the difference of present embodiment and a upper embodiment is that among the upper embodiment, dress is the high pressure argon in the described steel cylinder 1, and in the present embodiment, dress is liquid nitrogen in the steel cylinder 1; In addition, present embodiment has also increased by a low-power heating device 19 in described steel cylinder 1, is used for making the small part liquid nitrogen become gaseous state, with the pressure in the increase steel cylinder 1, thereby liquid nitrogen is pressed into to the cold and hot cutter of described heat insulation.
When adopting the cold and hot treatment system works that liquid nitrogen freezes, cold treatment process is (the low temperature liquid nitrogen cooling technic) by point of a knife that low temperature liquid nitrogen flows through the cold and hot cutter of described heat insulation is lowered the temperature, rapid gasification by liquid nitrogen, can be refrigerated in second below-190 ℃ at 20-30, namely freezing rate is 200-300 ℃/min; Identical with a upper embodiment, in cold treatment process, the pathological tissues around the cold and hot cutter point of a knife of described heat insulation is frozen rapidly icing, forms ice hockey, and along with the carrying out of cold treatment process, the volume of ice hockey constantly increases.In the cold and hot treatment system that adopts that liquid nitrogen freezes, the thermotherapy process is identical with a upper embodiment, and also employing radio frequency (RF) heats, and wherein, rf frequency is 100kHz～100MHz.
Particularly, when adopting the low temperature liquid nitrogen cooling technic to carry out cold treatment in this system, under the guiding of nuclear magnetic resonance, NMR, the cold and hot cutter 5 of described heat insulation is inserted into pathological tissues, in tumor, point of a knife is positioned on the central point of described pathological tissues; The first valve 3, the 3rd valve 7, the 4th valve 12, heater 8, low-power heating device 19 and pump 11 are opened in described control module control, described low-power heating device 19 is by heating to the liquid nitrogen in the described steel cylinder 1, make the part liquid nitrogen gasification, wherein, described control module can be by the heat time heating time of the described low-power heating device 19 of control, make and keep a suitable pressure in the described steel cylinder 1, can flow on the point of a knife of the cold and hot cutter 5 of described heat insulation to guarantee liquid nitrogen; The liquid nitrogen that flows to point of a knife gasifies rapidly, absorbs a large amount of heats, so that the temperature of point of a knife descends rapidly, generally can be refrigerated in second below-190 ℃ at 20-30.Simultaneously, because the overwhelming majority is nitrogen in the reflux materials, therefore, can it be drawn back to waste gas bottle 14 by pump 11.In addition, the signal that described control module collects according to described the second air gauge 10, the flow by regulating pump 11 and regulate pressure in the described cold treatment module heat time heating time of heater 8 is with the flow of liquid nitrogen in the described cold treatment module of indirectly control.Under the monitoring of nuclear magnetic resonance, NMR, when treating that ice hockey surrounds whole pathological tissues, stop cold treatment, this moment, the first valve 3, the 3rd valve 7, the 4th valve 12, heater 8, low-power heating device 19 and pump 11 were closed in described control module control.
When this system carried out thermotherapy, described radio-frequency signal generator 16 was opened in described control module control, and ensuing radio-frequency (RF) thermotherapeutic process is identical with the radio-frequency (RF) thermotherapeutic process of a upper embodiment, does not repeat them here.
In the actual use of the cold and hot treatment of the present invention system, described cold treatment module and thermotherapy module are by the coordination alternation of control module, in addition can be according to the kind of pathological tissues, the position, the difference in big or small and period of living in, determine different cold and hot treatment schemes, such as the cold and hot cutter of heat insulation of selecting different model, the rate of temperature fall of cold treatment and the heating rate of thermotherapy are set, the number of times that the maximum temperature that thermotherapy will reach and cold and hot treatment replace, described control module is then implemented different cold and hot treatment processes according to selected different cold and hot treatment scheme, wherein, the number of times that replaces of described cold and hot treatment is to decide according to the change of state that pathological tissues kind and nuclear magnetic resonance, NMR monitor pathological tissues.
The cold and hot treatment of above-mentioned nuclear magnetic resonance, NMR compatible type of the present invention system, be adapted at working under the guiding in real time of nmr imaging technique (MRI), for traditional electronic computer x-ray tomography technology (CT), the radiation dose of nmr imaging technique is lower, and is higher to the resolution of soft tissue; For ultrasonic imaging technique, nmr imaging technique is the positioning tumor tissue more accurately, and the fragmentation effect of judgement tumor that can real-time high-efficiency.
Among the present invention, desired profile can be freely selected in adjusting by magnetic field, thereby avoided dynamically to observe, organizational structure is unintelligible, resolution is not high, there is pseudo-shadow, the deficiencies such as radioactivity are arranged, make in whole therapeutic process, can both carry out good Real Time Monitoring for the growth of the position of focus, ice hockey and the elimination situation that melts situation, focus.Therefore, the present invention can be accurately, rapidly, kill tumor cell neatly, and to normal surrounding tissue kill and wound regional smaller.
In addition, because the present invention's kill tumor cell more neatly, therefore greatly reduce the probability of postoperative recurrence.
Above-described specific embodiment; purpose of the present invention, technical scheme and beneficial effect are further described; institute is understood that; the above only is specific embodiments of the invention; be not limited to the present invention; within the spirit and principles in the present invention all, any modification of making, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (13)
1. the cold and hot treatment of nuclear magnetic resonance, NMR compatible type system is characterized in that this system comprises:
Cold treatment module, it further comprises intake channel and the path of giving vent to anger, described intake channel is used for low-temperature receiver is guided to the point of a knife of the cold and hot cutter of described heat insulation (5), and it comprises successively: be equipped with low-temperature receiver steel cylinder (1), be used for measuring the first air gauge (2), first valve (3) of the pressure of described steel cylinder (1); The described path of giving vent to anger is used for absorbing the waste gas that cold treatment process produces, and it comprises successively: the 3rd valve (7), the heater (8) that is used for the described path of giving vent to anger is heated, the second air gauge (10) that is used for measuring the pressure of the described path of giving vent to anger, mobile pump (11), the 4th valve (12) that power is provided that is used to low-temperature receiver, be used for the waste gas bottle (14) of the waste gas that accommodating therapeutic process produces;
The thermotherapy module, it comprises radio-frequency signal generator (16) and radio-frequency (RF) thermotherapeutic antenna, described radio-frequency signal generator (16) links to each other with described radio-frequency (RF) thermotherapeutic antenna with control module, for generation of rf wave; Described radio-frequency (RF) thermotherapeutic antenna runs through the cold and hot cutter of whole heat insulation (5), its end is connected with described radio-frequency signal generator (16) by rf signal line, it places the top at the point of a knife place of the cold and hot cutter of described heat insulation (5), is used for launching the rf wave that described radio-frequency signal generator (16) produces;
The cold and hot cutter of the branched heat insulation that can control separately (5), be used for being inserted into pathological tissues and carry out cold and hot treatment, the knife bar inside of the cold and hot cutter of each heat insulation (5) includes an argon pipeline and a radio-frequency (RF) thermotherapeutic antenna, the argon pipeline causes cold and hot jet blade to the high pressure argon, the cold and hot cutter of each heat insulation (5) also is provided with the air inlet and the gas outlet that is connected the described path of giving vent to anger that connect described intake channel, and is used to cold treatment process that low-temperature receiver is provided and gets rid of the waste gas that produces in the cold treatment process;
Temperature sensor is installed in the point of a knife of the cold and hot cutter of described heat insulation (5), and is connected with described control module, is used for the temperature of the cold and hot cutter of the described heat insulation of Real-time Collection (5) point of a knife;
Control module, at least comprise one with described pump (11) be connected the computer (15) that radio-frequency signal generator (16) is connected, be used for the transmitting power of regulating flow and the described radio-frequency signal generator (16) of described pump (11) according to the signal that the parameter of setting in advance and described temperature sensor and the second air gauge (10) are passed back.
2. system according to claim 1 is characterized in that, described low-temperature receiver is high pressure argon or cryogenic liquid.
3. system according to claim 1 is characterized in that, described waste gas bottle (14) also is connected with one the 3rd air gauge (13), is used for measuring the pressure of described waste gas bottle (14).
4. system according to claim 1 is characterized in that, also is provided with an effusion meter (9) in the described path of giving vent to anger, and is used for measuring the flow of the described path low-temperature receiver of giving vent to anger.
5. system according to claim 1 is characterized in that, the pole of described radio-frequency (RF) thermotherapeutic antenna for being made by conductive material.
6. system according to claim 1 is characterized in that, the cold and hot cutter of described heat insulation (5) and coupled gas passage and described rf signal line are made with paramagnetic material.
7. system according to claim 1 is characterized in that, is embedded with the active adiabatic section based on thermal compensation on the knife bar of the cold and hot cutter of described heat insulation (5), is frozen injury to avoid pathological tissues normal structure on every side.
8. system according to claim 1 is characterized in that, the air inlet of the cold and hot cutter of described heat insulation (5) is connected to connect respectively an air relief valve with the gas outlet, to prevent that low-temperature receiver pressure is excessive and damage the cold and hot cutter of described heat insulation.
9. system according to claim 2, it is characterized in that, when described low-temperature receiver is the high pressure argon, also be provided with afterwards a cryogenic liquid bottle (17) and one second valve (18) at described the first valve (3), be used for carrying out pre-cooling from described steel cylinder (1) high pressure argon out.
10. system according to claim 9 is characterized in that, when described low-temperature receiver is the high pressure argon, under the guiding of nuclear magnetic resonance, NMR, the cold and hot cutter of described heat insulation (5) is inserted in the pathological tissues, and point of a knife is positioned on the central point of described pathological tissues; The first valve (3) is opened in described control module control, the second valve (18), the 3rd valve (7), the 4th valve (12), heater (8) and pump (11), carry out pre-cooling by cryogenic liquid bottle (17) first from described steel cylinder (1) high pressure argon out, then arrive the point of a knife of the cold and hot cutter of described heat insulation (5) through one section transfer tube, described high pressure argon is sprayed into the gas backstreaming chamber of the larger cold and hot cutter inside of volume ratio by the argon pipe end at the cutter head place, this moment, the pressure of argon was down to rapidly normal pressure, cooling class throttle effect occurs, so that the temperature of point of a knife descends rapidly; Simultaneously, the argon of backflow is drawn back to waste gas bottle (14) by pump (11); Wherein, the signal that described control module gathers according to described the second air gauge (10), flow by regulating pump (11) and regulate pressure in the described cold treatment module heat time heating time of heater (8) is with the flow of argon in the described cold treatment module of indirectly control; Under the monitoring of nuclear magnetic resonance, NMR, when treating that ice hockey surrounds whole pathological tissues, stop cold treatment, this moment, the first valve (3), the second valve (18), the 3rd valve (7), the 4th valve (12), heater (8) and pump (11) were closed in described control module control.
11. system according to claim 2, it is characterized in that, when described low-temperature receiver is cryogenic liquid, also be provided with a low-power heating device (19) in the described steel cylinder (1), be used for making the small part liquid nitrogen become gaseous state, with the pressure in the increase steel cylinder (1), thereby liquid nitrogen is pressed into to the cold and hot cutter of described heat insulation.
12. system according to claim 11 is characterized in that, when described low-temperature receiver is cryogenic liquid, under the guiding of nuclear magnetic resonance, NMR, the cold and hot cutter of described heat insulation (5) is inserted in the pathological tissues, and point of a knife is positioned on the central point of described pathological tissues; The first valve (3), the 3rd valve (7), the 4th valve (12), heater (8), low-power heating device (19) and pump (11) are opened in described control module control, wherein, described control module is by the heat time heating time of the described low-power heating device of control (19), make and keep a suitable pressure in the described steel cylinder (1), can flow on the point of a knife of the cold and hot cutter of described heat insulation (5) to guarantee liquid nitrogen; The liquid nitrogen that flows to point of a knife gasifies rapidly, absorbs a large amount of heats, so that the temperature of point of a knife descends rapidly; Simultaneously, the waste gas that produces in the therapeutic process is drawn back to waste gas bottle (14) by pump (11); Wherein, the signal that described control module gathers according to described the second air gauge (10), flow by regulating pump (11) and regulate pressure in the described cold treatment module heat time heating time of heater (8) is with the flow of liquid nitrogen in the described cold treatment module of indirectly control; Under the monitoring of nuclear magnetic resonance, NMR, when treating that ice hockey surrounds whole pathological tissues, stop cold treatment, this moment, the first valve (3), the 3rd valve (7), the 4th valve (12), heater (8), low-power heating device (19) and pump (11) were closed in described control module control.
13. according to claim 9 or 11 described systems, it is characterized in that, when this system carries out thermotherapy, described radio-frequency signal generator (16) is opened in described control module control, the described radio-frequency (RF) thermotherapeutic antenna that is connected with described radio-frequency signal generator (16) sends the high-frequency radio frequency ripple, thereby excites the pathological tissues generation ion concussion heat production around the cold and hot cutter of described heat insulation, along with the continuous rising of pathological tissues self temperature, ice hockey melts gradually, and final so that ice hockey all melts.
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| CN201210590514.8A CN103027742B (en) | 2012-12-31 | 2012-12-31 | Nuclear magnetic resonance compatible cold-thermal therapy system |
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| CN103549992A (en) * | 2013-11-22 | 2014-02-05 | 上海导向医疗系统有限公司 | Mixed gas feeder of target knife and method for controlling cooling capacity output |
| CN104720890A (en) * | 2015-03-11 | 2015-06-24 | 福建医科大学附属第一医院 | Split type multipole electrode needle compatible with magnetic resonance and radio frequency ablation |
| CN105708541A (en) * | 2016-04-11 | 2016-06-29 | 赵国江 | Control method for throttling freezing type cryosurgery device |
| CN107205766A (en) * | 2014-11-13 | 2017-09-26 | 艾达吉欧医疗公司 | The Cryoablation system and correlation technique of pressure controlling |
| CN107320105A (en) * | 2017-07-24 | 2017-11-07 | 北京大学 | The Magnetic resonance imaging and electromagnetic induction and RF therapy system of a kind of combination |
| CN110215276A (en) * | 2019-07-16 | 2019-09-10 | 孙悦 | A kind of refrigerating plant for treating preauricular flstula |
| CN111643178A (en) * | 2019-05-20 | 2020-09-11 | 上海申赞科贸有限公司 | Tumor ablation cold-hot alternate treatment equipment |
| WO2021109206A1 (en) * | 2019-12-04 | 2021-06-10 | 海杰亚（北京）医疗器械有限公司 | High and low temperature composite ablation surgery system |
| CN113406543A (en) * | 2021-08-19 | 2021-09-17 | 深圳市联影高端医疗装备创新研究院 | Temperature regulation and control system |
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| CN103549992A (en) * | 2013-11-22 | 2014-02-05 | 上海导向医疗系统有限公司 | Mixed gas feeder of target knife and method for controlling cooling capacity output |
| CN103549992B (en) * | 2013-11-22 | 2015-07-29 | 上海导向医疗系统有限公司 | The method that targeting cutter mist feeder and control cold export |
| CN107205766A (en) * | 2014-11-13 | 2017-09-26 | 艾达吉欧医疗公司 | The Cryoablation system and correlation technique of pressure controlling |
| CN107205766B (en) * | 2014-11-13 | 2020-04-14 | 艾达吉欧医疗公司 | Pressure regulated cryoablation system and related methods |
| CN104720890A (en) * | 2015-03-11 | 2015-06-24 | 福建医科大学附属第一医院 | Split type multipole electrode needle compatible with magnetic resonance and radio frequency ablation |
| CN105708541A (en) * | 2016-04-11 | 2016-06-29 | 赵国江 | Control method for throttling freezing type cryosurgery device |
| CN107320105A (en) * | 2017-07-24 | 2017-11-07 | 北京大学 | The Magnetic resonance imaging and electromagnetic induction and RF therapy system of a kind of combination |
| CN107320105B (en) * | 2017-07-24 | 2023-11-28 | 北京大学 | Combined nuclear magnetic resonance imaging and electromagnetic induction and radio frequency treatment system |
| CN111643178A (en) * | 2019-05-20 | 2020-09-11 | 上海申赞科贸有限公司 | Tumor ablation cold-hot alternate treatment equipment |
| CN110215276A (en) * | 2019-07-16 | 2019-09-10 | 孙悦 | A kind of refrigerating plant for treating preauricular flstula |
| WO2021109206A1 (en) * | 2019-12-04 | 2021-06-10 | 海杰亚（北京）医疗器械有限公司 | High and low temperature composite ablation surgery system |
| CN113406543A (en) * | 2021-08-19 | 2021-09-17 | 深圳市联影高端医疗装备创新研究院 | Temperature regulation and control system |
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