CN103157178A - Seal type tool capable of accurately controlling microneedle insertion length - Google Patents
Seal type tool capable of accurately controlling microneedle insertion length Download PDFInfo
- Publication number
- CN103157178A CN103157178A CN2013100454743A CN201310045474A CN103157178A CN 103157178 A CN103157178 A CN 103157178A CN 2013100454743 A CN2013100454743 A CN 2013100454743A CN 201310045474 A CN201310045474 A CN 201310045474A CN 103157178 A CN103157178 A CN 103157178A
- Authority
- CN
- China
- Prior art keywords
- micropin
- length
- connector
- baffle plate
- end cap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003780 insertion Methods 0.000 title abstract 4
- 230000037431 insertion Effects 0.000 title abstract 4
- 239000000758 substrate Substances 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 3
- 238000005452 bending Methods 0.000 claims description 2
- 230000008859 change Effects 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 8
- 210000003491 skin Anatomy 0.000 description 26
- 238000010586 diagram Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 206010020880 Hypertrophy Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000004531 microgranule Substances 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Abstract
The invention discloses a seal type tool capable of accurately controlling microneedle insertion length and relates to the technical field of medicine delivery and skin minimally invasive devices. The seal type tool capable of accurately controlling the microneedle insertion length comprises a needle body, a baffle, a protection shell and a rear needle body length adjusting mechanism. Due to the fact that skin thickness is different or different length microneedles are needed in a certain treatment stage, the microneedle insertion length adjustment tool has strong adaptability to different parts of skin treatment. A seal type is adopted by the integral design, by twisting an end cover, the length of the microneedle can be adjusted, and gap distance between the end cover and the protection shell is adjusted. The length of the microneedle extending out of the baffle is adjusted, a locating pin can fall in different grooves of a connection column, so that the accurate control of microneedle extending length is achieved.
Description
Technical field:
The present invention relates to medicine controlled releasing and skin Wicresoft device, particularly the seal style instrument of accurate control micropin intubating length.
Background technology:
Traditional percutaneous dosing be medicine by the passive corium that diffuses into of epidermis passage, then enter body circulation through blood capillary.Cuticular obstruction causes the most drug molecule to pass through, and rate of release is difficult to reach the purpose for the treatment of too slowly, and people have taked various measures to destroy horny layer to strengthen skin to the infiltration of medicine for this reason.The microneedle array that is comprised of the micropin of 10-2000 μ m is a kind of relatively new route of administration, it not only can pierce through the upper strata epidermis and create and allow the even micron-scale passage that passes through of microgranule of medicine macromole, and unlikely exciting nerve produces the damage that pain causes clinical meaning again.
Skin is divided into three layers from outside to inside: horny layer, epidermal area and skin corium.The cutin bed thickness is 10-20 μ m approximately, is that one deck is extremely organized, and there is no blood vessel and nerve, but the controlled release layer of percutaneous drug absorption; Epidermal area is positioned at outer subcutaneous approximately 50-100 μ m place, contains a small amount of living cells and nerve, does not contain blood vessel; More contain a large amount of living cells, nerve and blood vessel in the corium of depths.Micropin is the micron-sized pin of difformity, structure and the material made by Micrometer-Nanometer Processing Technology, and by producing at keratodermatitis the permeability that medicine is improved in small duct, this is a kind of administering mode between subcutaneous injection and transdermal patch.
General traditional method, active nutrient can only infiltrate through the barrier layer (being horny layer) of epidermis, and effect is remarkable (only reaching approximately 0. 3 percent effect) not.Utilize the small syringe needle chafe of micropin, make active component effectively infiltrate skin, micropin stimulates skin corium simultaneously, percutaneous self-healing ability, promote the ossein hypertrophy, can the match in excellence or beauty plastic operation of laser and filled type of the thickness hypertrophy that can make skin epidermis approximately 8 percent, its effect.And the side effect of micropin technology is extremely low, and is safe and reliable.
Summary of the invention:
The seal style instrument that the purpose of this invention is to provide accurate control micropin intubating length, because skin thickness is different, perhaps some treatment stage needs the micropin of different length, so the length-adjustable seal style micropin of the present invention.
Accurately control the seal style instrument of micropin intubating length, be provided with microneedle array on a side of substrate 5, the opposite side of substrate 5 is provided with the connector 4 of fixing base 5 cylindrical bumps, connector 4 is along week upwards having some locating slots, connector 4 and end cap 3 are threaded connection, and end cap 3 is positioned at a side that is not provided with microneedle array on connector 4, end cap 3 is connected with positioning tube 1, spring and alignment pin 2 are installed in positioning tube 1, spring is against in locating slot on connector 4 alignment pin 2 between positioning tube 1 and alignment pin 2; Open on containment vessel 6 that on reeded circular hole and connector 4, the cylinder with boss coordinates, prevent from relatively rotating between connector 4 and containment vessel 6.The coupling part of substrate 5 and connector 4 is in containment vessel 6.Have the micropore corresponding with micropin on baffle plate 7, located mutually by the small boss on baffle plate 7 and the groove fit on containment vessel 6, the micropin on substrate 5 can lean out baffle plate 7 by micropore.When micropin uses, press end cap 3, end cap 3 containment vessel 6 of can conflicting, the distance of advancing this moment is the length that micropin on substrate 5 leans out baffle plate 7.And due to the existence of micropore on baffle plate 7, micropin can be constrained in the hole, improve the counter-bending ability of micropin.During rotary end cover 3, being threaded of connector 4 and end cap 3 can change the distance of regulating end cap 3 and containment vessel 6 gaps, and alignment pin 2 drops in the different groove of connector 4, leans out the length of baffle plate 7 to reach the fine adjustment micropin.Alignment pin in positioning tube 1 drops in the different groove of connector 4 to reach the accurate control that micropin is leant out length.The outside of containment vessel 6 has demarcates the scale that leans out pin length, the groove that end cap 3 has.When there is no baffle plate 7, the baffle plate 7 in the outside of containment vessel 6 can make skin smooth, thrusts error due to what the radian of skin caused when reducing microneedle array and penetrating skin, and accurately micropin inserts the length of skin, and micropin leans out the length of baffle plate between 0.2mm～2mm.
In described microneedle array, the material of pin is metal or polymer.
In described microneedle array, pin is shaped as taper shape, rhizoma sparganic taper or rectangular pyramid shape.
Utilize the small syringe needle chafe of micropin, make active component effectively infiltrate skin, micropin stimulates skin corium simultaneously, and percutaneous self-healing ability can be used for the desalination of small rut and skin scar.
The present invention compares with background technology, and the useful effect that has is:
Different local skin thickness differ, the length of the length adjustable system scalable micropin of micropin, to reach the purpose of reply different-thickness skin, baffle plate can accurately insert the length of skin, and the micropin of different length skin is produced different Wicresofts, the growth of chafe.
The micropin baffle plate can stop most of dirt, is convenient to cleaning.And baffle plate helps skin-tightening, is beneficial to the treatment of micropin.
Description of drawings:
Fig. 1 is the structural representation of integral body of the present invention.
Fig. 2 is the schematic diagram of micropin substrate.
Fig. 3 is the schematic diagram of micropin baffle plate.
Fig. 4 is micropin containment vessel schematic diagram.
Fig. 5 is micropin connector schematic diagram.
Fig. 6 is micropin alignment pin schematic diagram.
Fig. 7 is micropin end cap schematic diagram.
In figure: 1, positioning tube, 2, alignment pin, 3, end cap, 4, connector, 5, substrate, 6, containment vessel, 7, baffle plate.
The specific embodiment:
Further illustrate below in conjunction with accompanying drawing, referring to Fig. 2, Fig. 3, Fig. 4, shown in Figure 5, because micropin is also probably damaged due to extraneous factor and pollute in used time not, of the present invention and baffle plate 7 contact skin prevents that dust from entering the micropin gap on substrate 5, make micropin be convenient to cleaning, length that micropin enters skin that it is not only accurate, and little rigidity that helps to improve micropin.
Different local skin thickness differ, the length of the length adjustable system scalable micropin of micropin, to reach the purpose of reply different-thickness skin, baffle plate 7 can accurately insert the length of skin, and the micropin of different length skin is produced different Wicresofts, at different treatment stages, skin is produced different stimulations, be beneficial to the growth of skin.
In projection in Fig. 3 on baffle plate 7 and Fig. 4, the groove of the outer ring of containment vessel 6 matches; In Fig. 5 in the projection of connector 4 and Fig. 4 the groove of containment vessel 6 inner rings match.
Claims (3)
1. accurately control the seal style instrument of micropin intubating length, it is characterized in that: be provided with microneedle array on a side of substrate (5), the opposite side of substrate (5) is provided with the connector (4) of fixing base (5) cylindrical bump, connector (4) is along week upwards having some locating slots, connector (4) and end cap (3) are threaded connection, and end cap (3) is positioned at a side that is not provided with microneedle array on connector (4), end cap (3) is connected with positioning tube (1), spring and alignment pin (2) are installed in positioning tube (1), spring is between positioning tube (1) and alignment pin (2), alignment pin (2) is against in locating slot on connector (4), open reeded circular hole on containment vessel (6) and coordinate with the upper cylinder with boss of connector (4), prevent from relatively rotating between connector (4) and containment vessel (6), the coupling part of substrate (5) and connector (4) is in containment vessel (6), baffle plate has the micropore corresponding with micropin on (7), is located mutually by the small boss on baffle plate (7) and the groove fit on containment vessel (6), and the micropin on substrate (5) can lean out baffle plate (7) by micropore, when micropin uses, press end cap (3), end cap (3) containment vessel (6) of can conflicting, the distance of advancing this moment is the length that micropin on substrate (5) leans out baffle plate (7), and the existence due to the upper micropore of baffle plate (7) can constrain in micropin in the hole, improves the counter-bending ability of micropin, during rotary end cover (3), being threaded of connector (4) and end cap (3) can change the distance of regulating end cap (3) and containment vessel (6) gap, alignment pin (2) drops in the different groove of connector (4), leans out the length of baffle plate (7) to reach the fine adjustment micropin, alignment pin in positioning tube (1) drops in the different groove of connector (4) to reach the accurate control that micropin is leant out length, the outside of containment vessel (6) has demarcates the scale that leans out pin length, the groove that end cap (3) has, when there is no baffle plate (7), the baffle plate (7) in the outside of containment vessel (6) can make skin smooth, thrust error due to what the radian of skin caused when reducing microneedle array and penetrating skin, accurately micropin inserts the length of skin, and micropin leans out the length of baffle plate between 0.2mm～2mm.
2. the seal style instrument of accurate control micropin intubating length according to claim 1, it is characterized in that: in described microneedle array, the material of pin is metal or polymer.
3. the seal style instrument of accurate control micropin intubating length according to claim 1 is characterized in that: in described microneedle array, pin is shaped as taper shape, rhizoma sparganic taper or rectangular pyramid shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310045474.3A CN103157178B (en) | 2013-02-05 | 2013-02-05 | Seal type tool capable of accurately controlling microneedle insertion length |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310045474.3A CN103157178B (en) | 2013-02-05 | 2013-02-05 | Seal type tool capable of accurately controlling microneedle insertion length |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103157178A true CN103157178A (en) | 2013-06-19 |
| CN103157178B CN103157178B (en) | 2014-12-31 |
Family
ID=48581030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310045474.3A Expired - Fee Related CN103157178B (en) | 2013-02-05 | 2013-02-05 | Seal type tool capable of accurately controlling microneedle insertion length |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103157178B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105126243A (en) * | 2015-09-06 | 2015-12-09 | 游学秋 | Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device |
| CN106693159A (en) * | 2017-01-24 | 2017-05-24 | 北京欧扬医疗美容门诊部有限公司 | Injecting type cosmetic instrument |
| CN107487091A (en) * | 2017-05-09 | 2017-12-19 | 盛利涛 | It is a kind of can authorizing band printing forme protection intelligent seal |
| CN107921248A (en) * | 2015-07-24 | 2018-04-17 | 金伯利-克拉克环球有限公司 | Method for more preferably delivering from activating agent to tumour |
| WO2018099437A1 (en) * | 2016-12-01 | 2018-06-07 | Huang Sin Ger | Microneedle array chip |
| CN108245775A (en) * | 2017-12-25 | 2018-07-06 | 中山大学 | The portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth |
| CN108310616A (en) * | 2018-01-24 | 2018-07-24 | 苑凯华 | A kind of micro- needle roller device of adjustable skin with synchronous injection administration functions |
| CN113975619A (en) * | 2021-11-11 | 2022-01-28 | 浙江大学 | Device and method for controlling microneedle penetration based on light |
Citations (5)
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|---|---|---|---|---|
| US4109655A (en) * | 1975-10-16 | 1978-08-29 | Manufacture Francaise d'Armes et Cycles de Saint-Etienne Manufrance | Multi-penetration vaccination apparatus |
| CN1190904A (en) * | 1995-07-14 | 1998-08-19 | 贝林格尔·英格海姆公司 | Transcorneal drug-release system |
| US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US20030135161A1 (en) * | 2002-01-15 | 2003-07-17 | Fleming Patrick R. | Microneedle devices and methods of manufacture |
| CN101208129A (en) * | 2005-06-27 | 2008-06-25 | 3M创新有限公司 | Microneedle cartridge assembly and method of applying |
-
2013
- 2013-02-05 CN CN201310045474.3A patent/CN103157178B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4109655A (en) * | 1975-10-16 | 1978-08-29 | Manufacture Francaise d'Armes et Cycles de Saint-Etienne Manufrance | Multi-penetration vaccination apparatus |
| CN1190904A (en) * | 1995-07-14 | 1998-08-19 | 贝林格尔·英格海姆公司 | Transcorneal drug-release system |
| US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US20030135161A1 (en) * | 2002-01-15 | 2003-07-17 | Fleming Patrick R. | Microneedle devices and methods of manufacture |
| CN101208129A (en) * | 2005-06-27 | 2008-06-25 | 3M创新有限公司 | Microneedle cartridge assembly and method of applying |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107921248A (en) * | 2015-07-24 | 2018-04-17 | 金伯利-克拉克环球有限公司 | Method for more preferably delivering from activating agent to tumour |
| CN105126243A (en) * | 2015-09-06 | 2015-12-09 | 游学秋 | Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device |
| CN105126243B (en) * | 2015-09-06 | 2018-08-07 | 台州薇凯生物科技有限公司 | Microneedle injection bullet and preparation method thereof and microneedle injection equipment |
| WO2018099437A1 (en) * | 2016-12-01 | 2018-06-07 | Huang Sin Ger | Microneedle array chip |
| CN106693159A (en) * | 2017-01-24 | 2017-05-24 | 北京欧扬医疗美容门诊部有限公司 | Injecting type cosmetic instrument |
| CN106693159B (en) * | 2017-01-24 | 2023-12-22 | 北京欧扬医疗美容门诊部有限公司 | Injection type beauty instrument |
| CN107487091A (en) * | 2017-05-09 | 2017-12-19 | 盛利涛 | It is a kind of can authorizing band printing forme protection intelligent seal |
| CN107487091B (en) * | 2017-05-09 | 2023-09-19 | 盛利涛 | Intelligent seal with printing plate protection function |
| CN108245775A (en) * | 2017-12-25 | 2018-07-06 | 中山大学 | The portable microneedle transdermal delivery auxiliary device of controllable dynamics and depth |
| CN108310616A (en) * | 2018-01-24 | 2018-07-24 | 苑凯华 | A kind of micro- needle roller device of adjustable skin with synchronous injection administration functions |
| CN113975619A (en) * | 2021-11-11 | 2022-01-28 | 浙江大学 | Device and method for controlling microneedle penetration based on light |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103157178B (en) | 2014-12-31 |
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Inventor after: Zhang Yajun Inventor after: Zhuang Jian Inventor after: Xue Ling Inventor after: Hao Junjiao Inventor after: Zhou Gang Inventor after: Wang Shengdan Inventor before: Zhang Yajun Inventor before: Zhuang Jian Inventor before: Xue Ling Inventor before: Zhang Shaojing Inventor before: Hao Junjiao Inventor before: Zhou Gang |
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Free format text: CORRECT: INVENTOR; FROM: ZHANG YAJUN ZHUANG JIAN XUE LING ZHANG SHAOJING HAO JUNJIAO ZHOU GANG TO: ZHANG YAJUN ZHUANG JIAN XUE LING HAO JUNJIAO ZHOU GANG WANG SHENGDAN |
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Inventor after: Zhang Yajun Inventor after: Zhuang Jian Inventor after: Xue Ling Inventor after: Hao Junjiao Inventor after: Zhou Gang Inventor after: Wang Shengdan Inventor after: Li Meijiao Inventor before: Zhang Yajun Inventor before: Zhuang Jian Inventor before: Xue Ling Inventor before: Hao Junjiao Inventor before: Zhou Gang Inventor before: Wang Shengdan |
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| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG YAJUN ZHUANG JIAN XUE LING HAO JUNJIAO ZHOU GANG WANG SHENGDAN TO: ZHANG YAJUN ZHUANG JIAN XUE LING HAO JUNJIAO ZHOU GANG WANG SHENGDAN LI MEIJIAO |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141231 Termination date: 20160205 |
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| CF01 | Termination of patent right due to non-payment of annual fee |