CN103300938B - Trans-atrial pathway atrioventricular valve regurgitation animal modeling device - Google Patents
Trans-atrial pathway atrioventricular valve regurgitation animal modeling device Download PDFInfo
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- CN103300938B CN103300938B CN201310261639.0A CN201310261639A CN103300938B CN 103300938 B CN103300938 B CN 103300938B CN 201310261639 A CN201310261639 A CN 201310261639A CN 103300938 B CN103300938 B CN 103300938B
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Abstract
The invention provides a trans-atrial pathway atrioventricular valve regurgitation animal modeling device. The device comprises a cutting rod for cutting a valve and an outer sleeve (2) with a sealed communicating pipe, wherein the outer sleeve (2) with the sealed communicating pipe comprises a communicating pipe (7) and a hollow metal pipe (8) which are communicated in a sealed manner; the cutting rod (1) is mounted in the hollow metal pipe (8) in a matched manner. The invention also discloses a trans-atrial pathway atrioventricular valve regurgitation animal modeling method. The trans-atrial pathway atrioventricular valve regurgitation animal modeling device provided by the invention have the advantages of simplicity and convenience in operation, easiness in use, low cost, easily controllable regurgitation amount, high modeling rate and no X-ray radiation risk, can achieve accurate positioning of valve leaflets, and has a wide application range.
Description
Technical field
The present invention relates to the device and method that animal disease model makes, especially a kind of producing device for large animal chamber valvular regurgitation disease model and method.
Background technology
Valvular regurgitation is a kind of clinical common cardiac disorder, wherein common clinically with mitral incompetence (mitral regurgitation, MR), it is reported, ultrasonic examination mild MR can up to 19% at normal population, and moderate MR or severe MR is respectively 1.9% and 0.2%.Mitral incompetence makes left atrium and left ventricular diastolic load increase the weight of, and pulmonary vein and pulmonary capillary pressure can be caused to raise, then cause vasodilation and congestion; Left ventricular diastolic volume load increases simultaneously, and left ventricle dilation, if acute serious mitral incompetence, can make left atrium and pulmonary vein pressure sharply rise, and causes acute lung edema.Chronic MR harm is also large, and diagnosis and treatment easily atrial fibrillation will occur not in time, and also often cause pulmonary venous pleonaemia and the low inferior left heart failure of body circumfusion, pulmonary hypertension and whole heart failure can appear in late period, direct life-threatening.Just because of this, the clinical importance of MR is subject to increasing attention, research about the mechanism of MR, Pathophysiology feature and diagnosis and treatment new technique is extensively carried out, some new video diagnostic technologies, especially the generation development and change mechanism of atrial fibrillation, in the fields such as the medical and surgical treatment means evaluation of heart failure, study hotspot all needs a large animal model of good stable MR.
Set up this kind of animal model at present to reach mainly through the primary structure destroying, change or affect the Mitral valve structure such as lobe leaf, chordae tendineae, papillary muscles, lobe ring, left atrium or left ventricle and affect valve tight closure, thus cause blood from ventricle reflux to atrium, reach the object making the large animal model of chamber valvular regurgitation.Wherein the most easily realized by damage lobe leaf and chordae tendineae.Make animal valvular regurgitation model by this method and have two approach: open breast and do not open breast.Traditional method opening the making mitral incompetence model of breast generally need destroy valve or chordae tendineae through left auricle operation severs by extracorporeal circulation under direct-view, and the model that these class methods make is comparatively homogeneous, and definitely, but expense is higher, and wound is larger; Also have the die-manufacturing method damaged by Bicuspid valve through apex position under seeing a kind of beating heart, this method similar technology difficulty is large, and wound is still larger.The main finger of method not opening breast by intubation intervention technology under the guidance of X-ray, valve or chordae tendineae is destroyed by special nipper, this method generally needs by ultrasonic judgement reflux size, operate under X-ray owing to needing special nipper, technical requirement is higher, difficulty is large, cost is high, the controllability of long distance operation model is also poor, often or pull too heavy, mortality rate is very high, pull lighter, model is homogeneous not, operate comparatively loaded down with trivial details, it is poor that model can repeat, normal need injection of contrast medium repeatedly, consumptive material is expensive, under modelling personnel need be exposed to x-ray, the practical application of this method is made to be subject to a definite limitation, the foundation of mitral incompetence model was once trapped in bottleneck stage.
From the above mentioned, existing chamber valvular regurgitation animal disease model mold making technology exists following not enough: traditional surgery wound is comparatively large, animal easy infection, and mortality of animals is high, costly; The method not opening breast under getting involved x-ray needs special molding instrument, operate loaded down with trivial details, technical difficulty greatly, not easily grasp anti-uninterrupted, modelling repeatable poor, mortality rate is high, model homogeneity is poor, normal need injection of contrast medium repeatedly, consumptive material is expensive, modelling personnel and animal all need to be exposed to heavy dose of roentgen radiation x, make its scope of application limited.
Summary of the invention
In order to overcome above-mentioned technical problem, the object of the invention is for current chamber valvular regurgitation animal disease model in the urgent need to, the wound of tradition disease model surgery preparation method is large, easily send out and infect, mortality of animals is high, costly shortcoming, provides a kind of through atrium approach chamber valvular regurgitation animal model producing device.
Another object of the present invention is to provide a kind of method made through atrium approach chamber valvular regurgitation animal model.
To achieve these goals, one of the present invention, through atrium approach chamber valvular regurgitation animal model producing device, comprises the cutter bar for cutting valve and the trocar sheath of band sealing communicating pipe, wherein:
The trocar sheath of described band sealing communicating pipe comprises communicating pipe and hollow metal pipe;
Described communicating pipe is communicated with the hollow metal seal of tube;
Described cutter bar is supporting to be arranged in hollow metal bar.
Described cutter bar comprises the cutting barb that metallic rod is connected with metallic rod bottom.
Described cutter bar also comprises hand-held external member, and hand-held external member is fixedly connected on the other end of metallic rod.
The trocar sheath of described band sealing communicating pipe also comprises seal header joints; Wherein:
Described seal header joints is provided with sealing circular hole and side seal connecting hole;
Described hollow metal pipe is tightly connected with sealing circular hole;
Described communicating pipe and side seal connecting hole are tightly connected.
The trocar sheath of described band sealing communicating pipe also comprises valve, and the other end of valve and communicating pipe is tightly connected.
A kind of through atrium approach chamber valvular regurgitation animal model manufacture method, comprise the steps:
1) open breast at the 2-3 intercostal minimal incision * of the animal through preoperative medication, cut pericardium, the trocar sheath of band sealing communicating pipe is inserted left or right auricle, enters left or right atrium, continue deeply through mitral valve;
2) when the hollow metal pipe of the trocar sheath of band sealing communicating pipe is through PM, by cutter bar through hollow metal pipe, make cutter bar tangle valvular tissue, more back withdraw from cutter bar.
Described step 2) in cutter bar through sealing circular hole insert after, through hollow metal pipe, make the cutting barb of cutter bar tangle valvular tissue, more back withdraw from cutter bar.
Advantage through atrium approach chamber valvular regurgitation animal model producing device and method of the present invention is:
1. use minimal incision * to make animal chamber valvular regurgitation model manipulation through atrium atrioventricular valves (A V valves) film reflux animal model producing device simple, be easy to use, mini-invasive incision can be realized, heart is without the need to stoping jumping, can sxemiquantitative control without the need to extracorporeal circulation, reflux amount, accurately can navigate to the lobe leaf intending destroying, become mould rate high.
2. using valve shearing device to make animal valvular regurgitation model without the need to using x-ray imaging, without x-ray radiation is dangerous, cost is low, be easy to popularization, can extensively use.
Accompanying drawing explanation
Fig. 1 is an embodiment of the present invention front view.
Fig. 2 is cutter bar front view in an embodiment of the present invention.
Fig. 3 is the trocar sheath front view of band sealing communicating pipe in an embodiment of the present invention.
Detailed description of the invention
Below with reference to the accompanying drawings embodiments of the invention are described.The element described in an accompanying drawing of the present invention or a kind of embodiment and feature can combine with the element shown in one or more other accompanying drawings or embodiment and feature.It should be noted that for purposes of clarity, accompanying drawing and eliminate expression and the description of unrelated to the invention, parts known to persons of ordinary skill in the art or process in illustrating.
Below in conjunction with accompanying drawing, the present invention is described further.
Fig. 1 is an embodiment of the present invention front view, as shown in fig. 1, one of the present invention is through atrium approach chamber valvular regurgitation animal model producing device, comprise the cutter bar 1 for cutting valve and the trocar sheath 2 of band sealing communicating pipe, wherein: the trocar sheath 2 of described band sealing communicating pipe comprises communicating pipe 7 and hollow metal pipe 8; Communicating pipe 7 is communicated with hollow metal pipe 8 sealing.
Fig. 2 is cutter bar front view in an embodiment of the present invention, as shown in Figure 2, described cutter bar 1 comprises metallic rod 4, cutting barb 5, hand-held external member 3 are formed, and metallic rod 4 one end is provided with cutting barb 5, and hand-held external member 3 is fixedly connected on the other end of metallic rod 4.Wherein, described hand-held external member 3 is made up of plastic material, with the stricture of vagina road being convenient to grip or grip; Described metallic rod 4 is made up of intensity rustless metal, and diameter is not more than trocar sheath 2 internal diameter of band sealing communicating pipe, is preferably 3mm; Length is slightly longer than the trocar sheath 2 of band sealing communicating pipe, preferred 20cm; Described cutting barb 5 is in " L " hook scraper shape, and its cross section is no more than metallic rod place cross section.
Fig. 3 is the trocar sheath front view of band sealing communicating pipe in an embodiment of the present invention, and as shown in Figure 3, the trocar sheath 2 of described band sealing communicating pipe comprises seal header joints 6, communicating pipe 7, hollow metal pipe 8, three-way valve 11; Wherein: described seal header joints 6 is provided with sealing circular hole 9 and side seal connecting hole 10; Hollow metal pipe 8 is tightly connected with sealing circular hole 9; Communicating pipe 7 and side seal connecting hole 10 are tightly connected; , three-way valve 11 is tightly connected with the other end of communicating pipe 7.
Wherein, described seal header joints 6 is that a short cylindrical, hollow plastic material is made, described sealing circular hole 9 center of circle and the hollow metal pipe 8 cross section center of circle are on the same line, the diameter of sealing circular hole 9 is identical in hollow metal pipe 8, and described hollow metal pipe 8 is made up of the stainless hollow metal of intensity, and diameter is greater than metallic rod 4, preferred internal diameter is 3.5mm, preferred external diameter is 4mm, and length is less than metallic rod 4, and preferred diameter is 15cm; Described communicating pipe 7 makes for plastic hollow flexible pipe, and one end is connected to seal header joints 6, and the other end is connected with three-way valve 11.
Of the present inventionly through atrium approach chamber valvular regurgitation animal model manufacture method be:
Before using, first the animal general anaesthesia of molding will be treated, tracheal intubation, set up venous channel, if set up left side chamber valvular regurgitation model, animal right arm reclining, 2-3 intercostal minimal incision * opens breast, cut pericardium, left auricle to be sewed it up pocket, the trocar sheath 2 of band sealing communicating pipe is inserted left auricle through the pocket that pre-stitching is good, enter left room, continuing deeply will through mitral valve, speed emergency now by the blood flowed out communicating pipe 7 judges whether hollow metal pipe 8 enters ventricle, when hollow metal pipe 8 enters through PM, take out cutter bar 1 to insert through the sealing circular hole 9 of seal header joints 6, through hollow metal pipe 8, after barb 5 to be cut stretches out from hollow metal pipe 8, can sound out toward withdrawing, slightly firmly cutter bar 1 is back withdrawn from after sensation cutting barb 5 tangles valvular tissue, now valve can be cut off, complete molding operation, other chamber valvular regurgitation animal disease models can refer to mitral incompetence animal disease model manufacture method analogue formation, can the success condition of Real Time Observation molding by equipment such as ultrasonic machines.
The present invention is simple to operation, is easy to use, and cost is low, anti-flow easy-control, becomes mould rate high, dangerous without x-ray radiation, is that one can accurately locate lobe leaf, the special valvular regurgitation animal disease model producing device that operation strategies is wide.
Although described the present invention and advantage thereof in detail, be to be understood that and can have carried out various change when not exceeding the spirit and scope of the present invention limited by appended claim, substituting and conversion.And the scope of the application is not limited only to the specific embodiment of process, equipment, means, method and step described by description.One of ordinary skilled in the art will readily appreciate that from disclosure of the present invention, can use perform the function substantially identical with corresponding embodiment described herein or obtain and its substantially identical result, existing and that will be developed in the future process, equipment, means, method or step according to the present invention.Therefore, appended claim is intended to comprise such process, equipment, means, method or step in their scope.
Claims (5)
1. through an atrium approach chamber valvular regurgitation animal model producing device, it is characterized in that: comprise the cutter bar (1) for cutting valve and the trocar sheath (2) of band sealing communicating pipe, wherein:
The trocar sheath (2) of described band sealing communicating pipe comprises communicating pipe (7) and hollow metal pipe (8);
Described communicating pipe (7) is communicated with hollow metal pipe (8) sealing;
Described cutter bar (1) is supporting to be arranged in hollow metal bar (8).
2. according to claim 1 through atrium approach chamber valvular regurgitation animal model producing device, it is characterized in that: described cutter bar (1) comprises the cutting barb (5) that metallic rod (4) is connected with metallic rod (4) bottom.
3. according to claim 1 and 2 through atrium approach chamber valvular regurgitation animal model producing device, it is characterized in that: described cutter bar (1) also comprises hand-held external member (3), hand-held external member (3) is fixedly connected on the other end of metallic rod (4).
4. according to claim 1 through atrium approach chamber valvular regurgitation animal model producing device, it is characterized in that: the trocar sheath (2) of described band sealing communicating pipe also comprises seal header joints (6); Wherein:
Described seal header joints (6) is provided with sealing circular hole (9) and side seal connecting hole (10);
Described hollow metal pipe (8) is tightly connected with sealing circular hole (9);
Described communicating pipe (7) and side seal connecting hole (10) are tightly connected.
5. according to claim 1 or 4 through atrium approach chamber valvular regurgitation animal model producing device, it is characterized in that: the trocar sheath (2) of described band sealing communicating pipe also comprises valve (11), and valve (11) is tightly connected with the other end of communicating pipe (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310261639.0A CN103300938B (en) | 2013-06-27 | 2013-06-27 | Trans-atrial pathway atrioventricular valve regurgitation animal modeling device |
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| CN201310261639.0A CN103300938B (en) | 2013-06-27 | 2013-06-27 | Trans-atrial pathway atrioventricular valve regurgitation animal modeling device |
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| Publication Number | Publication Date |
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| CN103300938A CN103300938A (en) | 2013-09-18 |
| CN103300938B true CN103300938B (en) | 2015-05-20 |
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| CN201310261639.0A Expired - Fee Related CN103300938B (en) | 2013-06-27 | 2013-06-27 | Trans-atrial pathway atrioventricular valve regurgitation animal modeling device |
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| CN108403249A (en) * | 2018-01-24 | 2018-08-17 | 四川省人民医院 | A kind of aortic incompetence animal model making device |
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| WO2011012894A1 (en) * | 2009-07-31 | 2011-02-03 | Exstent Limited | Improvements in or relating to blood vessel supports |
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| CN103300938A (en) | 2013-09-18 |
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