CN103566412A - Safe composite lucifugal medical tube and manufacturing method thereof - Google Patents
Safe composite lucifugal medical tube and manufacturing method thereof Download PDFInfo
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- CN103566412A CN103566412A CN201310575185.4A CN201310575185A CN103566412A CN 103566412 A CN103566412 A CN 103566412A CN 201310575185 A CN201310575185 A CN 201310575185A CN 103566412 A CN103566412 A CN 103566412A
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Abstract
The invention belongs to the field of medical apparatuses, in particular to a safe composite lucifugal medical tube and a manufacturing method thereof. The safe composite lucifugal medical tube comprises two or more tube layers, wherein the adjacent tube layers are made of different materials; an inner material in contact with medicinal liquid is thermoplastic polyurethane elastomer, polytetrafluoroethylene, polyethylene, polypropylene or polyester; an outer material which makes no contact with the medicinal liquid is polyvinyl chloride, thermoplastic polyurethane elastomer, polytetrafluoroethylene, polyethylene, polypropylene or polyester; a colorant is added into the outer material. The inner layer of the safe composite lucifugal medical tube is made of a non-PVC medical polymer material, so that in the infusion process, DEHP precipitation is avoided and the safety of the safe composite lucifugal medical tube is improved; the outer layer of the safe composite lucifugal medical tube is made of a medical polymer material added with the colorant, so that the safe composite lucifugal medical tube is lucifugal in the infusion process, and the lucifugal colorant makes no contact with the medicinal liquid.
Description
Technical field
The invention belongs to medical instruments field, relate in particular to a kind of safety composite photophobic medical pipe and manufacture method thereof.
Background technology
In clinical some drugs infusion process, need lucifuge, otherwise there will be photochemical degradation, photosensitivity reaction, phototoxicity etc., these photochemical reactions have reduced the proper value of medicine, and the problem such as even have side effects.As nitre Pu Na, nitroglycerin, vitamin B
2, Santonin, codeine etc.Clinically, for guaranteeing the safety and reliability of its treatment, these chemically unstables, meet that light is rotten, variable color, the medicine that photosensitivity reaction, phototoxicity etc. even can occur all need be in infusion process lucifuge in addition, just can reach its therapeutic effect.
Traditional photophobic medical pipe adopts medical polyvinyl (PVC) to add the method for coloring agent conventionally, owing to containing dihexylphthalate (DEHP) and dioctyl phthalate (DOP) in medical PVC, wherein, plasticizer DEHP in some fat milk medicine energy stripping PVC transfusion devices, health is threatened, and some medicines can adsorb by PVC, lessen the curative effect.Zoopery also proves that such plasticizer can carcinogenic, teratogenesis, has been listed in genotoxicity agent, also has the heavy metals such as some calcium, magnesium as stabilizing agent.PVC(polrvinyl chloride) method that adds coloring agent also easily occurs that coloring agent is separated out, transport phenomena, causes the pollution that medicinal liquid is new, has increased the insecurity of such tubing clinical practice.
Based on above reason, be badly in need of providing a kind of safety composite photophobic medical pipe, guarantee the safety of some drugs infusion.
Summary of the invention
(1) technical problem that will solve
The object of this invention is to provide a kind of safety composite photophobic medical pipe and manufacture method thereof, this medical tubing is safe, and in infusion medicinal liquid process, reaches the function of lucifuge.
(2) technical scheme
For solving the problems of the technologies described above, the invention provides a kind of safety composite photophobic medical pipe, it is characterized in that, comprise 2 layers or 2 layers of above pipe layer, and adjacent pipe layer material is different, the inner layer material contacting with medicinal liquid adopts Polyurethane Thermoplastic Elastomer or politef or polyethylene or polypropylene or polyester, the cladding material not contacting with medicinal liquid adopts polrvinyl chloride or Polyurethane Thermoplastic Elastomer or politef or polyethylene or polypropylene or polyester, in described cladding material, is added with coloring agent.
Preferably, described medical tubing is made by 2 layers of different macromolecular material, and the thickness of described internal layer is 0.03-0.8mm, and described outer field thickness is 0.03-0.8mm.
The present invention also provides a kind of manufacture method of safety composite photophobic medical pipe, described medical tubing is made by 2 layers of different macromolecular material, the inner layer material contacting with medicinal liquid adopts Polyurethane Thermoplastic Elastomer or politef or polyethylene or polypropylene or polyester, the cladding material not contacting with medicinal liquid adopts polyethylene or polypropylene or polyester, in described cladding material, be added with coloring agent, it is characterized in that, said method comprising the steps of:
S1: draw inner layer pipe;
S2: draw outer heat-shrinkable tube, and make the internal diameter of described outer tube be a bit larger tham the external diameter of described inner layer pipe;
S3: described outer tube is enclosed within described inner layer pipe, then heating.
Preferably, described medical tubing is made by 3 floor height molecular materials, between described internal layer and described skin, is provided with middle support layer, and described middle support layer adopts inertia macromolecular material.
Preferably, the thickness of described middle support layer is 0.03-0.8mm.
Preferably, described inertia macromolecular material is polyethylene or polypropylene.
Preferably, the thickness of described internal layer is 0.03-0.8mm, and described outer field thickness is 0.03-0.8mm.
The present invention also provides a kind of manufacture method of safety composite medical tubing, it is characterized in that, comprises the following steps:
S1: according to the number of plies selection material of medical tubing and get the raw materials ready according to formula metering;
S2: the raw material of each layer of medical tubing is joined single screw extrusion machine separately from each hopper, through melting by same molding mixed gear end extruded stock pipe;
S3: by material pipe stretch, cooling, sizing.
(3) beneficial effect
Safety composite photophobic medical pipe and manufacture method thereof that technique scheme provides, the inner layer material contacting with medicinal liquid adopts Polyurethane Thermoplastic Elastomer or politef or polyethylene or polypropylene or polyester, and the cladding material not contacting with medicinal liquid adopts polrvinyl chloride or Polyurethane Thermoplastic Elastomer or politef or polyethylene or polypropylene or the polyester that adds coloring agent.Because internal layer adopts non-PVC medical macromolecular materials, therefore in infusion process, without DEHP, separate out, improved its safety; And the outer medical macromolecular materials that add coloring agent that adopt are made, make this medical tubing in infusion process, reach the function of lucifuge, and lucifuge coloring agent is not contacted with medicinal liquid.In addition, this medical tubing manufacturing process is simple, and manufacturing cost is lower.
Accompanying drawing explanation
Fig. 1 is the structural representation of a preferred embodiment of safety composite photophobic medical pipe of the present invention.
Fig. 2 is the structural representation of another preferred embodiment of safety composite photophobic medical pipe of the present invention.
Wherein: 1-is outer; 2-middle support layer; 3-internal layer.
The specific embodiment
Below in conjunction with drawings and Examples, the specific embodiment of the present invention is further described.Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Figure 1 shows that a preferred embodiment of safety composite photophobic medical pipe of the present invention.According to this embodiment, this medical tubing is double-layer structure: the skin 1 not contacting with medicinal liquid and the internal layer 3 contacting with medicinal liquid.Wherein, skin 1 and internal layer 3 are made from a variety of materials respectively.
Wherein, the internal layer 3 employing Polyurethane Thermoplastic Elastomer (TPU) that contact with medicinal liquid or polytetrafluoroethylene (PTFE) or polyethylene (PE) or polypropylene (PP) or polyester (PET) etc. are made, and thickness is between 0.03mm-0.8mm.
Preferably, internal layer 3 materials of medical tubing adopt TPU, because TPU has advantages of high-wearing feature, hardness range is wide and good springiness, mechanical strength is high, tolerance to cold is outstanding, good processability, oil resistant, water-fast, resistance to mycete and regeneration is good, convenient recovery.
Outer 1 employing polrvinyl chloride (PVC) or Polyurethane Thermoplastic Elastomer (TPU) or polytetrafluoroethylene (PTFE) or polyethylene (PE) or polypropylene (PP) or polyester (PET) etc. are made.In addition, in outer 3 materials that adopt, be added with coloring agent, make the light of wavelength between 290nm～450nm be less than 15% to the transmitance of tubing.
Preferably, the skin 1 of medical tubing adopts the polrvinyl chloride (PVC) that is added with coloring agent to make, because PVC material has low price, fire-retardant (fire-retardant value is more than 40), chemical proofing high (nitric acid that the sulphuric acid that resistance to concentrated hydrochloric acid, concentration are 90%, concentration are 60% and the sodium hydroxide of concentration 20%), advantages such as geometrical stability that mechanical strength is high and good.
The skin 1 of medical tubing directly contacts with the external world, be the protective layer of internal layer 1, thereby it is destroyed to be easy to be subject to extraneous factor to affect, so it,, except having in material requirement, also has requirement on thickness.If outer 1 too thin, not only do not have the effect of protection tubing, also can when matching with miscellaneous part, coordinate not closely, cause the appearance of the situations such as leakage, therefore the thickness of skin 3 is between 0.03-0.8mm.Be added with coloring agent due to outer 1, making wavelength is that light between 290nm～450nm is less than 15% to the transmitance of tubing.
When in this embodiment, the skin 1 of medical tubing adopts polyethylene (PE) or polypropylene (PP) or polyester (PET) to make, this medical tubing can be made by the method for thermal contraction, and the method specifically comprises the following steps:
S1: draw inner layer pipe;
S2: draw outer heat-shrinkable tube, and make outer tube internal diameter be a bit larger tham inner layer pipe external diameter;
S3: described outer tube is enclosed within described inner layer pipe, and then heating is fixed on internal layer tubing skin.
Figure 2 shows that a preferred embodiment of safety composite photophobic medical pipe of the present invention.According to this embodiment, this medical tubing is three-decker: the internal layer 3 contacting with medicinal liquid, the skin 1 not contacting with medicinal liquid, and between internal layer 3 and outer 1 for supporting the intermediate layer 2 of whole tubing, wherein, the material that adjacent pipe layer adopts is different, outer 1 adopt with middle support layer 2 material different, and middle support layer 2 is different with the material that internal layer 3 adopts.
Wherein, the internal layer 3 employing Polyurethane Thermoplastic Elastomer (TPU) that contact with medicinal liquid or polytetrafluoroethylene (PTFE) or polyethylene (PE) or polypropylene (PP) or polyester (PET) etc. are made, and thickness is between 0.03mm-0.8mm.Preferably, the internal layer 3 of medical tubing adopts polyurethane (TPU) material.
Outer 3 employing polrvinyl chloride (PVC) or Polyurethane Thermoplastic Elastomer (TPU) or polytetrafluoroethylene (PTFE) or polyethylene (PE) or polypropylene (PP) or polyester (PET) etc. are made, thickness is between 0.03mm-0.8mm, in addition, in outer 3 materials that adopt, be added with coloring agent, make the light of wavelength between 290nm～450nm be less than 15% to the transmitance of tubing.Preferably, the skin 3 of medical tubing adopts polrvinyl chloride (PVC) material.
Preferably, the middle support layer of medical tubing 2 adopts polyethylene (PE) or polypropylene (PP), because polyethylene (PE) or polypropylene (PP) have higher rigidity, hardness and intensity, and good counter-bending fatigability, thermostability etc.
Due to the physical difference opposite sex of inner and outer pipes material, during combination, easily there is the situation that composite can not be combined closely completely, this just causes the combination difficulty of compound tubing.If combination well between material, at bending pipe or when being subject to other external force, is easy to produce space between pipe, make like this harmful substance in middle support layer 2 and outer 1 still can ooze out.In order to address the above problem, the present invention also provides a kind of preparation method of manufacturing above-mentioned medical tubing, and it comprises the following steps:
S1: according to the number of plies selection material of composite medical tubing and get the raw materials ready according to formula metering;
S2: the raw material of each layer of medical tubing is joined single screw extrusion machine separately from each hopper, through melting by same molding mixed gear end extruded stock pipe;
S3: by material pipe stretch, cooling, sizing.
This medical tubing is realized the gapless adhesion between multilamellar by the mode of co-extrusion, and layer glueds joint not containing any adhesive with layer, thus the safety that improves this medical tubing.
Above embodiment is only for the present invention is described, and limitation of the present invention not, the those of ordinary skill in relevant technologies field, without departing from the spirit and scope of the present invention, can also make a variety of changes and modification.Therefore all technical schemes that are equal to also belong to protection category of the present invention.
Claims (8)
1. a safety composite photophobic medical pipe, it is characterized in that, comprise 2 layers or 2 layers of above pipe layer, and adjacent pipe layer material is different, the inner layer material contacting with medicinal liquid adopts Polyurethane Thermoplastic Elastomer or politef or polyethylene or polypropylene or polyester, the cladding material not contacting with medicinal liquid adopts polrvinyl chloride or Polyurethane Thermoplastic Elastomer or politef or polyethylene or polypropylene or polyester, in described cladding material, is added with coloring agent.
2. medical tubing according to claim 1, is characterized in that, described medical tubing is made by 2 layers of different macromolecular material, and the thickness of described internal layer is 0.03-0.8mm, and described outer field thickness is 0.03-0.8mm.
3. the manufacture method of a safety composite photophobic medical pipe, described medical tubing is made by 2 layers of different macromolecular material, and adjacent pipe layer material is different, the inner layer material contacting with medicinal liquid adopts Polyurethane Thermoplastic Elastomer or politef or polyethylene or polypropylene or polyester, the cladding material not contacting with medicinal liquid adopts polyethylene or polypropylene or polyester, in described cladding material, be added with coloring agent, it is characterized in that, said method comprising the steps of:
S1: draw inner layer pipe;
S2: draw outer heat-shrinkable tube, and make the internal diameter of described outer tube be a bit larger tham the external diameter of described inner layer pipe;
S3: described outer tube is enclosed within described inner layer pipe, then heating.
4. medical tubing according to claim 1, it is characterized in that, described medical tubing is made by 3 floor height molecular materials, and adjacent pipe layer material is different, between described internal layer and described skin, be provided with middle support layer, described middle support layer adopts inertia macromolecular material.
5. medical tubing according to claim 4, is characterized in that, the thickness of described middle support layer is 0.03-0.8mm.
6. medical tubing according to claim 4, is characterized in that, described inertia macromolecular material is polyethylene or polypropylene.
7. medical tubing according to claim 4, is characterized in that, the thickness of described internal layer is 0.03-0.8mm, and described outer field thickness is 0.03-0.8mm.
According to claim 1,2 or 4-8 in the manufacture method of safety composite medical tubing described in any one, it is characterized in that, comprise the following steps:
S1: according to the number of plies selection material of medical tubing and get the raw materials ready according to formula metering;
S2: the raw material of each layer of medical tubing is joined single screw extrusion machine separately from each hopper, through melting by same molding mixed gear end extruded stock pipe;
S3: by material pipe stretch, cooling, sizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310575185.4A CN103566412A (en) | 2013-11-15 | 2013-11-15 | Safe composite lucifugal medical tube and manufacturing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310575185.4A CN103566412A (en) | 2013-11-15 | 2013-11-15 | Safe composite lucifugal medical tube and manufacturing method thereof |
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| CN103566412A true CN103566412A (en) | 2014-02-12 |
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| CN201310575185.4A Pending CN103566412A (en) | 2013-11-15 | 2013-11-15 | Safe composite lucifugal medical tube and manufacturing method thereof |
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Cited By (5)
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| CN105879133A (en) * | 2016-03-31 | 2016-08-24 | 四川南格尔生物科技有限公司 | Blood plasma virus inactivation device and method |
| CN106667768A (en) * | 2016-12-30 | 2017-05-17 | 湖南金健药业有限责任公司 | Light-avoiding antibacterial infusion bag and preparation method thereof |
| CN110585503A (en) * | 2018-06-12 | 2019-12-20 | 上海立马医疗器械有限公司 | Hose and extracorporeal circulation pipeline adopting same |
| CN111002673A (en) * | 2019-12-18 | 2020-04-14 | 脉通医疗科技(嘉兴)有限公司 | Medical tube and preparation method thereof |
| CN113352659A (en) * | 2021-05-27 | 2021-09-07 | 江苏斯凯氟复合材料有限公司 | Preparation method of poly-tetra-ethylene composite membrane |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105879133A (en) * | 2016-03-31 | 2016-08-24 | 四川南格尔生物科技有限公司 | Blood plasma virus inactivation device and method |
| CN106667768A (en) * | 2016-12-30 | 2017-05-17 | 湖南金健药业有限责任公司 | Light-avoiding antibacterial infusion bag and preparation method thereof |
| CN110585503A (en) * | 2018-06-12 | 2019-12-20 | 上海立马医疗器械有限公司 | Hose and extracorporeal circulation pipeline adopting same |
| CN111002673A (en) * | 2019-12-18 | 2020-04-14 | 脉通医疗科技(嘉兴)有限公司 | Medical tube and preparation method thereof |
| WO2021120740A1 (en) * | 2019-12-18 | 2021-06-24 | 脉通医疗科技(嘉兴)有限公司 | Medical tubing and manufacturing method thereof |
| CN113352659A (en) * | 2021-05-27 | 2021-09-07 | 江苏斯凯氟复合材料有限公司 | Preparation method of poly-tetra-ethylene composite membrane |
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Application publication date: 20140212 |