CN103736200A - Preparation method of radioactive particle chain - Google Patents
Preparation method of radioactive particle chain Download PDFInfo
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- CN103736200A CN103736200A CN201310750640.XA CN201310750640A CN103736200A CN 103736200 A CN103736200 A CN 103736200A CN 201310750640 A CN201310750640 A CN 201310750640A CN 103736200 A CN103736200 A CN 103736200A
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Abstract
The invention relates to a preparation method of a radioactive particle chain. The preparation method is characterized by comprising the following steps: liquid preparation: preparing a forming liquid and a curing liquid; mold injection: injecting the forming liquid in a tubular mold, and injecting and arranging radioactive particles in the forming liquid in sequence, wherein the shape of the cross section of the tubular mold is not changed along the axial direction; curing: soaking the tubular mold in the curing liquid to complete the curing of the forming liquid; demolding: demolding after the step S3 is finished and then drying and forming. The preparation method is simple and convenient to design, easy to operate, low in cost, high in practicability and easy to realize volume production. The simple tubular mould is adopted, the complexity level of flow technology is decreased to the minimum; meanwhile, the tubular mold of which the cross section is not changed along the axial direction is used, and additional components with various functions can be convenient to add in the mold, so that the structural flexibility of the radioactive particle chain is greatly increased.
Description
Technical field
The present invention relates to radioactivity close-range treatment field, especially a kind of preparation method of radioactive particle chain.
Background technology
Malignant tumor is the major disease that threatens human health always, and utilizing radioactive particle to carry out Interstitial brachytherapy tumor is the new technique growing up nearly decades.Radioactive particle is a kind of small-sized radioactive source, and this radioactive source is contained in radiosiotope in titanium pipe, and two ends form sealed source with laser or electron beam technology welding, and its size is generally external diameter 0.8mm, and length is 4.5mm.The nucleic that radioactive particle is conventional has 192Ir, 198Au, 169Y, 131Cs, 103Pd and 125I etc., especially 103Pd and 125I.Close-range treatment is directly implanted focus by radioactive particle, closely prolonged exposure, destroy the DNA double key of neoplastic cell nuclei, lethal or sub-lethal tumor cell, make it lose replication capacity, thereby reach therapeutic purposes, isotope ray energy used is lower simultaneously, can effectively avoid ray to damage normal structure in irradiating on the way.
Radioactive particle Implantation in Treating tumor is a kind of very effective treatment means, there is the tumor of inhibition efficiency high, dose distribution is reasonable, the convenient advantages such as complementation that form with Operation cooperation, but after also existing radioactive particle to implant, in tissue, be subjected to displacement, the shortcoming such as particle implant surgery is loaded down with trivial details, and radioactive particle chain is the new technique having occurred since radioactive particle close-range treatment application, by physics or chemical method, the multiple assemblies such as radioactive particle, image label are assembled into particle chain by biocompatible materials (especially biodegradable).
The application of radioactive particle chain, tool has the following advantages: (1) radioactive particle chain no longer because migration situation appears in the reasons such as position chanP or the change of the tumor bodily form, makes particle dose distribution meet the source dosage requirement for the treatment of planning systems (TPS) cloth after implanting.(2) increased the indication of radioactive particle implantation, there is crumbly texture in tumor locus especially, and as tumor locus exists a large amount of bodies of gland, implant site is not suitable for the situation that single particle is implanted.(3) radioactive particle chain generally all has good elasticity and mechanical performance, and compliance distortion can occur along with dwindling of tumor tissues like this.(4) moulding material of radioactive particle chain is generally made by biocompatible materials (especially Biodegradable material), several weeks biodegradation time of material, the atrophy cycle of accepting the rear generation of radioactive particle irradiation with tumor is suitable, after treatment finishes, does not affect normal structure.(5) moulding material that radioactive particle chain is used does not directly contact radioactive particle with tumor tissues, avoided like this local organization because of the overdosage phenomenon that necroses.(6) by implant system, implant particle chain, can disposablely realize many radioactive particle layouts, reduced implant surgery time and medical personnel's exposure dose.(7) radioactive particle chain assembling is completed by producer, facilitates user, has improved added value of product.
The preparation of particle chain is mainly by the process of radioactive particle and moulding material assembled formation, and its assembling process is mainly by physics or chemical method, multiple radioactive particles and spacer rod or other assemblies to be coupled together.As U.S. Pat 6450939 discloses a kind of method, by the wedge button of particular design on spacer rod, radioactive particle is fixed into chain.And for example U.S. Pat 20040102671 discloses a kind of method, and radioactive particle is positioned over to reserved location, with the spacer rod arrangement of being separated by, utilizes hot melt moulding material, is solidified into chain.And for example U.S. Pat 2010261946 discloses a kind of method, and radioactive particle is woven in to chaining in hollow gauze.But above method has all adopted comparatively complicated Design of Dies, and preparation technology is loaded down with trivial details, is not easy to realize automatization and volume production.In view of above-mentioned defect, creator of the present invention has obtained this creation finally through long research and practice.
Summary of the invention
The object of the present invention is to provide a kind of radioactive particle chain preparation method in order to overcome above-mentioned technological deficiency.
For achieving the above object, the invention provides a kind of preparation method of radioactive particle chain, it is characterized in that, comprise step:
S1: prepare shaping dope and consolidation liquid;
S2: shaping dope is injected to tubular die, and radioactive particle is injected successively and be arranged in the shaping dope in mould, described tubular die vertically cross sectional shape is constant;
S3: described tubular die is immersed and completes solidifying of described shaping dope in described consolidation liquid;
S4: the demoulding drying and moulding after described step S3 completes.
Preferably, described step S2 also comprises and other assemblies is injected and be arranged in the shaping dope in mould.
Preferably, the internal diameter of described tubular die is greater than the maximum outside diameter in described radioactive particle and described other assemblies, and the internal diameter of described tubular die and described maximum outside diameter poor≤0.4mm.
Preferably, described tubular die material is tool semipermeable membrane character material.
Preferably, described shaping dope composition comprises alginate, described consolidation liquid composition comprises metal inorganic salt, and described alginate comprises soluble alginate, and described soluble alginate comprises one or more in sodium alginate, potassium alginate and ammonium alginate;
Described metal inorganic salt comprises and contains Ca
2+, Ba
2+, Mg
2+, Sr
2+, Fe
2+, Fe
3+or Al
3+metal inorganic salt in one or more.。
Preferably, the concentration of alginate described in described shaping dope is 0.2% to 2.0%(mass ratio), metal inorganic salinity described in described consolidation liquid is 0.5% to 10%(mass ratio).
Preferably, the concentration of alginate described in described shaping dope is 0.5%; Metal inorganic salinity described in described consolidation liquid be 0.5%, 1%, 2.5% or 5%(mass ratio).
Preferably, described shaping dope also comprises excipient and/or plasticizer;
Described excipient comprises one or more in starch and derivant, cellulose and derivant thereof, gelatin, pectin, agar, arabic gum, hyaluronic acid, chitosan, xanthan gum, Polyethylene Glycol, polyacrylic acid and derivant thereof, polyvinyl pyrrolidone and/or polyvinyl alcohol, and the concentration of described excipient is no more than 10%(mass ratio);
Described plasticizer comprises glycerol, sorbitol, and the concentration of plasticizer is no more than 10%(mass ratio).
Preferably, in described step S3, solidification temperature is 10 ℃ to 80 ℃, hardening time >=3h.
Preferably, it can also comprise step S5: the straight line chain radioactive particle chain obtaining after described step S4 is passed into and is fixed in a rectification structure;
Described rectification main structure body comprises one first stressor layers and one second stressor layers, described the first stressor layers is the semi-open or totally-enclosed tubular structure that cross section exceedes semicircle, described straight line chain radioactive particle chain can be fixed in described rectification structure by described the first stressor layers, described the second stressor layers is attached to described the first stressor layers one side, described the first stressor layers and described the second stressor layers all have internal stress, and equal and opposite in direction, opposite direction, described the first stressor layers degradation speed is faster than the shaping dope after solidifying, described the second stressor layers degradation speed than described solidify after shaping dope slow.
Beneficial effect of the present invention is compared with prior art: design easy, simple to operate, with low cost, practical, be easy to realize volume production.Adopt simple tubular die, flow process complexity dropped to minimum, use the constant tubular die of cross sectional shape vertically simultaneously, can be conveniently to the optional feature that adds various functions in mould, the configuration flexibility of radioactive particle chain is increased greatly.
Accompanying drawing explanation
Fig. 1 is a kind of radioactive particle chain preparation method of the present invention flow chart;
Fig. 2 is obtained product structure figure by a kind of radioactive particle chain preparation method of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing, technical characterictic and the advantage with other above-mentioned to the present invention are described in more detail.
Refer to shown in figure mono-, it is a kind of radioactive particle chain preparation method of the present invention flow chart.
A kind of radioactive particle chain preparation method of the present invention comprises following four steps successively:
Step S1: prepare shaping dope and consolidation liquid;
Step S2: injection molding;
Step S3: solidify;
Step S4: the demoulding.
Described step S1 comprises two steps, and the first step is for being used alginate configuration shaping dope, and second step is for being used inorganic metal salt configuration consolidation liquid.
Because alginate (monovalent salt is water soluble salt) can (as calcium, aluminum, iron ion) the water-insoluble gel of ionomer reaction formation occur under the existence of polyvalent metal ion, this process is called curing.In described step S1, first use the alginate of solubility to be configured to the solution of alginate, the alginate of wherein said solubility mainly comprises sodium alginate, potassium alginate and ammonium alginate, can use one or more in sodium alginate, potassium alginate and ammonium alginate to be mixed with shaping dope in preparation process.In layoutprocedure, solvent makes water, and preferably deionized water, in described shaping dope, the concentration of alginate is 0.2% to 2.0%(mass ratio), preferably 0.5%.
In described step S1, also need to prepare consolidation liquid, described consolidation liquid is used the aqueous solution of inorganic metal salt conventionally, and described inorganic metal salt is Ca
2+, Ba
2+, Mg
2+, Sr
2+, Fe
2+, Fe
3+, Al
3+deng can with the polyvalent metal ion salt of soluble alginate generation gelation reaction in one or more.Consolidation liquid concentration is unsuitable too low and too high, too lowly can not reach good solidification effect, too highly causes waste, with concentration 0.5%-10%(mass ratio) be advisable, preferably 0.5%, 1%, 2.5%, 5%.
In described step S1, described shaping dope and described consolidation liquid also can be used final mean annual increment solution.
If described shaping dope is only formulated by soluble alginate aqueous solution, after solidifying with consolidation liquid effect generation, mechanical performance is generally more fixing.When the product mechanical performance forming has the mechanical parameters such as stronger mechanical strength, elasticity, toughness, need to take measures to improve the curing process of shaping dope after needs solidify.
So, in the step of described configuration shaping dope, can also in described shaping dope, add the auxiliary material such as excipient and plasticizer to increase the mechanical performance after molding, the addible described excipient auxiliary material of described shaping dope are generally water-soluble high-molecular material, include but not limited to starch and derivant thereof, cellulose and derivant thereof, gelatin, pectin, agar, arabic gum, hyaluronic acid, chitosan, xanthan gum, Polyethylene Glycol, polyacrylic acid and derivant thereof, polyvinyl pyrrolidone and/or polyvinyl alcohol, the concentration of excipient is no more than 10%.The addible plasticizer of described shaping dope is generally polyalcohols, includes but not limited to glycerol, sorbitol, and the concentration of plasticizer is no more than 10%.
In described shaping dope, can also add other auxiliary material, such as matching used medicine, health product etc.
Described step S2: shaping dope is injected to tubular die, and radioactive particle (with other assemblies) is injected successively and be arranged in the shaping dope in mould.
Described tubular die hollow, the internal diameter of described tubular die be difficult for excessive be also difficult for too small, internal diameter is excessive, the arrangement linearity of radioactive particle in mould cannot guarantee, and the thickness of moulding material around particle also cannot guarantee its uniformity, internal diameter is too small, radioactive particle and other assemblies cannot inject, the internal diameter of described tubular die is advisable to be greater than radioactive particle or its assembly maximum outside diameter and to be no more than 0.4mm, consider the size of existing described radioactive particle at present, general described die size is 0.8-1.2mm.The length of mould, mates with the radioactive particle chain length of pre-making.The making material of mould is not limit, and preferably has the material of semipermeable membrane character, to facilitate polyvalent metal ion to infiltrate, carries out ionomer reaction.The not requirement of described tubular die cross section, can Tension Members with Arbitrary Shape Section, but described tubular die cross sectional shape is constant vertically.
In described step S2, first the described shaping dope of described step S1 configuration is injected to described tubular die, then described radioactive particle (with other assemblies) is injected to the described tubular die that has injected described shaping dope in order.
Described radioactive particle is radioactive source, and described other assemblies comprise distance member, also comprises that grappling radioactive particle chain position, labelling, spacer rod etc. have the assembly of function except radiation.Described distance member is preferably used biodegradation material, for isolating described radioactive particle, can play the effect of optimizing radiological dose; Described spacer rod is for shielding the radiation of described radioactive particle, for assist control radiological dose, and can realize by the structure of spacer rod the function of directed radiation; Described anchor assemblies is the position of described anchor point location structure for radioactive particle chain described in labelling or described radioactive particle, shaping dope after described solidifying is (if existed, also comprise described distance member) after degradation in vivo after a while, the structure of described radioactive particle chain has not existed, described radioactive particle is dispersed in injection canal, be difficult to find, anchor point location structure can be for ease of from visually or be convenient to be detected the structure that device detects, thereby after radiation therapy process, described radioactive particle is easily found.
In described step S3, mould is immersed in consolidation liquid and completes solidifying of described shaping dope, after described step S2 finishes, in described mould, by described radioactive particle, described other assemblies and described shaping dope, filled.Populated described mould is inserted in the container that is full of described consolidation liquid, be cured.
Described step S3 can carry out in room temperature, solidification temperature scope is 10 ℃ to 80 ℃, be preferably 23 ℃, solidification temperature is too high or solidification temperature is too low all can impact solidification process and cured product, do not get rid of the special curing process of special circumstances needs solidification process and cured product are controlled, but only provide general temperature value here.Should not be less than 3h hardening time, preferably 4h, is less than 3h hardening time and can causes engineering properties and the unstable chemcial property after solidifying.
After completing, described step S3 carries out described step S4, use boosting utensil that the gel column after solidifying is released, it is the demoulding, and by obtained gel column radioactive particle chain drying and moulding, have ready conditions and can be inserted vacuum drying oven, if condition does not allow can use the heaters such as baking oven, hot plate yet.
Reach the effect of fixing internal distance member and particle, give particle chain certain mechanical performance simultaneously, in organizational environment, can there is slowly deionization cross-linking reaction and dissolution phenomena occurs in the alginate gel after solidifying, although polysaccharide alginate is not had to special digestive enzyme in body, still can slowly there is the degradation effect of polysaccharide chain fracture in alginate in tissue.
A kind of radioactive particle chain preparation method of the present invention, it can also comprise step S5, the straight line chain radioactive particle chain obtaining after described step S4 is passed into and is fixed in a rectification structure, described rectification main structure body comprises the first stressor layers and the second stressor layers, described the first stressor layers is the semi-open or totally-enclosed tubular structure that cross section exceedes semicircle, described straight line chain radioactive particle chain can be fixed in described rectification structure by described the first stressor layers, described the second stressor layers is attached to described the first stressor layers one side, described the first stressor layers and described the second stressor layers all have internal stress, and equal and opposite in direction, opposite direction, described the first stressor layers and described the second stressor layers are human body degradation material, but described the first stressor layers degradation speed than described solidify after alginate fast, described the second stressor layers than described solidify after alginate slow.When described radioactive particle chain is not expelled in body, can present and keep radioactive particle chain is linearity, when being expelled in body, described the first stressor layers is degraded rapidly, described the second stressor layers has not had the stresses counteract of described the first stressor layers, by Stress Release out, cause the bending of described radioactive particle chain.This bending can remain to the alginate degraded after described solidifying.Adding of step S5 makes radioactive particle chain can before injection, keep regular shape, and after injection, can under the stress of described the second stressor layers, produce rapidly bending, reaches the effect of optimizing radiological dose.And described rectification structure can customize design in advance, greatly simplified technological process.
Embodiment mono-:
The present embodiment is preferred technical scheme, and reagent used is analytical pure.
Described step S1: prepare shaping dope, wherein sodium alginate (hyperviscosity specification) 0.5g, 10 grams of polyvinyl pyrrolidone (K-30), 10 grams of glycerol, 79.5 grams of deionized waters with alginate; Prepare consolidation liquid, wherein 0.5 gram, calcium chloride, 99.5 grams of deionized waters with inorganic metal salt;
Described step S2: shaping dope is injected to 1.0mm tubular die (rubber tube), and be that 125I radioactive particle that 0.8mm, length are 4.5mm injects successively and is arranged in the shaping dope in mould by 10 external diameters;
Described step S3: mould is immersed to 4h in consolidation liquid;
Described step S4: solidified the thin Glass rod of rear use the gel column after solidifying is released to the demoulding, and obtained gel column radioactive particle chain is positioned on filter paper, room temperature (23 ℃) is dried 24 hours aftershapings, makes described radioactive particle chain.
The radioactive particle chain making is detected, it is linear that outward appearance is, surface uniform, can pass through smoothly No. 18 piercing needles, radioactive particle chain two ends are positioned on two planks, middle unsettled, there is not the distortion producing because of deadweight in radioactive particle chain, and bear a heavy burden in the middle of the chain after 0.1 gram and still without naked eyes, be out of shape as seen, show radioactive particle chain stable mechanical performance, meet clinical instructions for use.
Embodiment bis-:
Step and method is with embodiment mono-, and difference part is: in described step S1, prepare shaping dope, wherein 20 grams of alginates (ultra-low viscosity specification), 5 grams, gelatin, 74 grams of deionized waters with alginate; Prepare consolidation liquid, wherein 5 grams, calcium chloride, 95 grams of deionized waters with inorganic metal salt.In described step S2, tubular die is that internal diameter is 0.9mm rustless steel needle tubing.In described step S3, mould is soaked in consolidation liquid to 24 hours.In described step S4,50 ℃ of vacuum dryings 2 hours.
Embodiment tri-:
Step and method is with embodiment mono-, and difference part is: in described step S1, prepare shaping dope, wherein 8 grams of alginates (low viscosity specification), 1 gram of glycerol, 91 grams of deionized waters with alginate; Prepare consolidation liquid, wherein 5 grams, iron chloride, 95 grams of deionized waters with inorganic metal salt.In described step S2, tubular die is that internal diameter is 0.9mm rustless steel needle tubing.In described step S3, mould is soaked in consolidation liquid to 24 hours.In described step S4,10 ℃ are dried 2 hours.
Embodiment tetra-:
Shown in Figure 2, it is obtained product structure figure by a kind of radioactive particle chain preparation method of the present invention.
Step and method is with embodiment mono-, difference part is: in described step S1, prepare shaping dope with alginate, 92.5 grams of 2 grams of alginates (medium viscosity specification), 5 grams of polyvinyl alcohol, 0.5 gram of glycerol, deionized water are prepared consolidation liquid with inorganic metal salt, wherein 5 grams, iron chloride, 95 grams of deionized waters.In described step S2, tubular die is that internal diameter is 1mm plastic tube, and the titanium pipe that use external diameter is 0.8mm is as described distance member.Successively 5 radioactivity I-125 particles and 4 titanium pipes are injected to mould, the described distance member in one, interval between every radioactive particle.In described step S3, mould is soaked in consolidation liquid to 24 hours, in described step S4 80 ℃ dry 1 hour.As shown in Figure 2, shaping dope becomes integument 51 after solidifying to the product forming, and is not wrapped in described radioactive particle 52(figure and does not all show) and described distance member 53(figure in not all demonstrations).
The foregoing is only preferred embodiment of the present invention, is only illustrative for invention, and nonrestrictive.Those skilled in the art is understood, and in the spirit and scope that limit, can carry out many changes to it in invention claim, revise, and even equivalence, but all will fall within the scope of protection of the present invention.
Claims (10)
1. a preparation method for radioactive particle chain, is characterized in that, comprises step:
S1: prepare shaping dope and consolidation liquid;
S2: shaping dope is injected to tubular die, and radioactive particle is injected successively and be arranged in the shaping dope in mould, described tubular die vertically cross sectional shape is constant;
S3: described tubular die is immersed and completes solidifying of described shaping dope in described consolidation liquid;
S4: the demoulding drying and moulding after described step S3 completes.
2. the preparation method of radioactive particle chain as claimed in claim 1, is characterized in that, described step S2 also comprises and other assemblies injected and be arranged in the shaping dope in mould.
3. the preparation method of radioactive particle chain as claimed in claim 2, it is characterized in that, the internal diameter of described tubular die is greater than the maximum outside diameter in described radioactive particle and described other assemblies, and the internal diameter of described tubular die and described maximum outside diameter poor≤0.4mm.
4. the preparation method of radioactive particle chain as claimed in claim 3, is characterized in that, described tubular die material is tool semipermeable membrane character material.
5. the preparation method of radioactive particle chain as claimed in claim 1, it is characterized in that, described shaping dope composition comprises alginate, described consolidation liquid composition comprises metal inorganic salt, described alginate comprises soluble alginate, and described soluble alginate comprises one or more in sodium alginate, potassium alginate and ammonium alginate;
Described metal inorganic salt comprises and contains Ca
2+, Ba
2+, Mg
2+, Sr
2+, Fe
2+, Fe
3+or Al
3+metal inorganic salt in one or more.
6. the preparation method of the radioactive particle chain as described in claim 1 to 5, it is characterized in that, the concentration of alginate described in described shaping dope is 0.2% to 2.0%(mass ratio), metal inorganic salinity described in described consolidation liquid is 0.5% to 10%(mass ratio).
7. the preparation method of the radioactive particle chain as described in claim 1 to 5, is characterized in that, the concentration of alginate described in described shaping dope is 0.5%; Metal inorganic salinity described in described consolidation liquid be 0.5%, 1%, 2.5% or 5%(mass ratio).
8. the preparation method of the radioactive particle chain as described in arbitrary claim in claim 1 to 5, is characterized in that, described shaping dope also comprises excipient and/or plasticizer;
Described excipient comprises one or more in starch and derivant, cellulose and derivant thereof, gelatin, pectin, agar, arabic gum, hyaluronic acid, chitosan, xanthan gum, Polyethylene Glycol, polyacrylic acid and derivant thereof, polyvinyl pyrrolidone and/or polyvinyl alcohol, and the concentration of described excipient is no more than 10%(mass ratio);
Described plasticizer comprises glycerol, sorbitol, and the concentration of plasticizer is no more than 10%(mass ratio).
9. the preparation method of the radioactive particle chain as described in arbitrary claim in claim 1 to 5, is characterized in that, in described step S3, solidification temperature is 10 ℃ to 80 ℃, hardening time >=3h.
10. the preparation method of the radioactive particle chain as described in arbitrary right in claim 1 to 5, is characterized in that, it can also comprise step S5: the straight line chain radioactive particle chain obtaining after described step S4 is passed into and is fixed in a rectification structure;
Described rectification main structure body comprises one first stressor layers and one second stressor layers, described the first stressor layers is the semi-open or totally-enclosed tubular structure that cross section exceedes semicircle, described straight line chain radioactive particle chain can be fixed in described rectification structure by described the first stressor layers, described the second stressor layers is attached to described the first stressor layers one side, described the first stressor layers and described the second stressor layers all have internal stress, and equal and opposite in direction, opposite direction, described the first stressor layers degradation speed is faster than the shaping dope after solidifying, described the second stressor layers degradation speed than described solidify after shaping dope slow.
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| CN104147688A (en) * | 2014-07-31 | 2014-11-19 | 吉林大学 | Rapidly-formed self-adaptive afterloading brachytherapy source applicator and manufacturing method thereof |
| CN106823120A (en) * | 2017-01-24 | 2017-06-13 | 原子高科股份有限公司 | A kind of preparation method of the degradable radioactive particle chain with shape memory function |
| CN111012929A (en) * | 2019-11-27 | 2020-04-17 | 原子高科股份有限公司 | Suppository carrying radioactive particles and preparation method thereof |
| CN111840586A (en) * | 2020-07-22 | 2020-10-30 | 原子高科股份有限公司 | Biodegradable radioactive particles, particle composition and preparation method |
| CN112967830A (en) * | 2021-02-01 | 2021-06-15 | 原子高科股份有限公司 | Beta plane source preparation method and beta plane source |
| WO2024011452A1 (en) * | 2022-07-13 | 2024-01-18 | 深圳先进技术研究院 | Method for preparing thin film and use of thin film |
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| CN111840586A (en) * | 2020-07-22 | 2020-10-30 | 原子高科股份有限公司 | Biodegradable radioactive particles, particle composition and preparation method |
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| CN112967830B (en) * | 2021-02-01 | 2024-01-16 | 原子高科股份有限公司 | Beta plane source preparation method and beta plane source |
| WO2024011452A1 (en) * | 2022-07-13 | 2024-01-18 | 深圳先进技术研究院 | Method for preparing thin film and use of thin film |
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