CN103747817B - 肾病患者的液体量监测 - Google Patents
肾病患者的液体量监测 Download PDFInfo
- Publication number
- CN103747817B CN103747817B CN201280020937.4A CN201280020937A CN103747817B CN 103747817 B CN103747817 B CN 103747817B CN 201280020937 A CN201280020937 A CN 201280020937A CN 103747817 B CN103747817 B CN 103747817B
- Authority
- CN
- China
- Prior art keywords
- liquid
- blood
- amount
- patient
- impedance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6866—Extracorporeal blood circuits, e.g. dialysis circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0295—Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0537—Measuring body composition by impedance, e.g. tissue hydration or fat content
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
- A61M1/1605—Physical characteristics of the dialysate fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
- A61M1/1605—Physical characteristics of the dialysate fluid
- A61M1/1607—Physical characteristics of the dialysate fluid before use, i.e. upstream of dialyser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1613—Profiling or modelling of patient or predicted treatment evolution or outcome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
- A61M1/361—Physical characteristics of the blood, e.g. haematocrit, urea before treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
- A61M1/3612—Physical characteristics of the blood, e.g. haematocrit, urea after treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/32—Controlling or regulating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
- G16Z99/00—Subject matter not provided for in other main groups of this subclass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3303—Using a biosensor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/3313—Optical measuring means used specific wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3507—Communication with implanted devices, e.g. external control
- A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/005—Parameter used as control input for the apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/207—Blood composition characteristics hematocrit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/208—Blood composition characteristics pH-value
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/65—Impedance, e.g. conductivity, capacity
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/12—Use of permeate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/40—Automatic control of cleaning processes
Abstract
一种使用,其包括通过一传感器装置监测一患者的一液体量指标,并根据监测到的液体量指标为一血液液体清除阶段设定一初始液体清除量处方。该使用可以进一步包括向血液液体清除装置传输来自于可植入传感器的关于液体量指标的数据。在一些实施例中,液体清除装置根据接收自可植入传感器的数据设定或计算该初始液体清除量处方。该液体量指标可以是一组织液体量指标或一血液液体量指标。
Description
相关申请
本申请要求申请日为2012年3月20日,申请号为13/424,467的美国专利申请的优先权,该美国专利申请要求申请号为61/480,539、61/480,544、61/480,541、61/480,535、61/480,532、61/480,530,以及61/480,528的美国临时申请的优先权,所述各优先权临时申请案的申请日均为2011年4月29日,所述各临时申请与本申请公开的内容不相矛盾的部分在此全部引用纳入本申请。
技术领域
本申请大致涉及监测肾病患者的液体量的装置、系统和使用。
背景技术
目前用于治疗第三期至第四期的慢性肾病患者的使用通常包括监测患者的症状和肾小球滤过率(GRF)。在患者达到需要以补充血液透析的形式进行额外治疗的数值前,通常会采用外科手术的方法将动脉转向血管以创建一个接入点(瘘管)。瘘管的成熟通常需要4-6周,但其需要6个月才能达到进行血液透析所需的成熟度。在某些情况下,患者的肾脏会快速衰竭,这使得在患者需要进行透析治疗前,瘘管仍未成熟。在这种情况下,中心静脉导管会一直使用到瘘管成熟。然而,中心静脉导管更易导致感染,且会遇到凝血问题和疲劳问题。因此,希望能够保证瘘管在患者需要进行血液透析之前成熟。遗憾的是,预判第三期至第四期的慢性肾病患者何时需要补充的血液透析治疗是非常困难的,且目前缺乏对这种患者的充分监测的使用。
一旦患者开始接受透析治疗或其他液体清除治疗(例如超滤法),很难确定在给定的治疗阶段过程中清除多少液体。液体清除的量在治疗阶段前确定,且与患者在治疗前的体重、治疗过程中的液体添加物以及患者的理论干体重(dry weight)相关。但是,患者的干体重(在肾脏功能正常的情况下,患者应具有的重量)很难精确确定。对于某一个给定的患者来说,在其肾脏功能正常的情况下,他的体重常常是不可知的变量,而且会随着时间而变化。然而,精确确定患者的干体重对于液体清除阶段获得成功的疗效是很重要的。
遗憾的是,患者的干体重通常不被频繁地估算或是重新评估。不同于患者的实际体重是在液体清除阶段前和后被称量,确定干体重的频次非常低,例如每月一次,且在确定干体重和给定的液体清除阶段之间的时间内,很多情况都会发生变化,而液体清除阶段通常是一周三次。作为液体清除考虑因素中的一个重要变量,干体重却通常很难估算,且会在液体清除阶段之间发生变化。
错误的液体清除量会在血液透析治疗之后或过程中导致严重的低血压和患者病危(crashing),并且不够频繁的液体清除阶段也会导致严重的后果。例如,猝死和心脏死亡常见于血液透析患者中(包括死于充血性心力衰竭,心肌梗塞以及猝死)。参见Bleyer等人著的《血液透析患者中猝死和心脏死亡率》,《国际肾脏期刊》,(1999),55:1152-1559[Bleyer et al,"Sudden andcardiac death rated in hemodialysis patients,"Kidney International,(1999),55:1552-1559.]。
基于各种原因,希望对进行血液液体清除阶段的患者进行额外监测。
发明内容
除了其他以外,本文描述了对接受或可能需要接受液体清除治疗(例如血液透析,超滤法等)的患者的液体量进行长期监测的装置、系统和使用。通过长期监测液体量的指标,可能能够更准确地预估第三期或第四期慢性肾病患者何时可能初始需要补充液体清除治疗,可能需要对何时创建瘘管做出更好的预估,以使瘘管在初始液体清除阶段时成熟。长期监测液体量的指标对于更准确地确定液体清除阶段中使用的适当液体清除参数(液体清除“处方”)也是具有意义的。
在本文所描述的各实施例中,一种使用包括:通过一传感器装置监测一患者的一液体量指标,并根据监测到的液体量指标为一血液液体清除阶段(ablood fluid removal session)设定一初始的液体清除量处方(initial fluid volumeremoval prescription)。该使用可以进一步地包括从可植入的传感器装置向液体清除装置传输的关于液体量指标的数据。在一些实施例中,液体清除装置根据接收自可植入的传感器的数据,设定或计算初始液体清除量处方。该液体量指标可能是一组织液体量的指标或是一血液液体量的指标。
在本文所描述的某些实施例中,一种系统包括:一构造为监测一液体量指标的传感器,以及一血液液体清除装置。该血液液体清除装置包括:(i)一入口,用于接受来自于一患者的血液;(ii)一第一出口,用于将来自于患者的血液送回;(iii)一中间装置(medium),用于将血液中的液体清除,该中间装置(medium)设于入口和第一出口之间;(iv)一液体清除速率控制器;(v)一第二出口,用于清除液体的流出;以及(vi)与液体清除速率控制器和传感器耦合的电子装置(electronics),所述电子装置构造为根据接收自传感器的数据设定一初始液体清除速率处方(prescription),并根据设定的初始液体清除速率处方控制液体清除速率控制器。
在本文所描述的多个实施例中,一种传感器装置包括:(i)一探测器电路和部件,其构造为获得一感测到的关于液体量指标的数据;以及(ii)电子控制装置(control electronic),其构造为从探测器电路接收获得的感测到的数据,并根据获得的感测到的数据计算一液体清除量处方。
本案所采用的关于液体量指标长期监测的装置和使用也可用于辅助确定在慢性肾病患者或在可能患有慢性肾病的患者体内创建瘘管的适宜时间。
本案所描述的系统、装置和使用的一个或多个实施例较之现有的用于对患者进行血液液体清除或是监测患者液体的系统、装置和使用可能具有一个或多个优点。例如,慢性肾病患者往往到晚期(第五期)才知道其病情。一旦患者病情达到第五期时,可选择的治疗是有限的,且血液透析往往是唯一的选择。如果监测可以帮助患者跟踪其肾脏功能(尤其是那些患有高血压和糖尿病的患者),那么这些患者可能采取除了透析以外的其他治疗方法,并且他们达到第五期的进程将会减慢。在患者接受利尿治疗的情况下,监测可以用于跟踪患者是否对治疗有反应。监测还有助于避免错误的诊断。例如,若忽视了损伤的肾功能,肾病患者可能仅仅会被诊断为高血压患者,从而错过了减缓慢性肾病进程的机会。对于高血压和糖尿病患者来说,本案所述的监测也是有价值的,因为三分之二的第五期的肾衰竭患者被认为是患有高血压和糖尿病的。在阅读了以下具体描述的基础上,这些和其他有益效果对于本领域内的技术人员来说均是显而易见的。
附图说明
这些附图构成了本说明书的一部分,其与说明书一起示出了本发明的几种实施方式,用来解释本发明的原理。附图只用于解释本发明的实施例,并不构成对本发明的限制。
图1-图2为显示了涉及患者的可穿戴的以及可植入的传感器的示意图。
图3为显示了传感器的选定的部件的示意框图。
图4为显示了传感器的选定的部件的示意框图,该传感器用于监测涉及管道的血液液体量指标。
图5-图6为显示了阻抗传感器在患者体外(图5)和植入患者体内(图6)的选定的部件的示意框图。
图7-图9为流程示意图,其显示了本案记载的各实施例中的使用的整个流程。
图10-图13为示意框图,其显示了根据本案记载的教示各实施例中所采用的液体清除装置。
图14-图15为示意框图,其显示了根据本案记载的各实施例所采用的血液液体清除装置或系统的选定的部件。
图16为示意框图,其显示了各传感器和电子控制装置(control electronic)之间的相互作用。
这里所呈现的示意图不是必须按比例的。图中使用相同的数字指代相似的部件、步骤等。然而,可以理解的是,在一个图中使用一个数字来指代一个部件,并非旨在限制该部件在另一图中也使用相同的数字标号。此外,使用不同的数字来指代部件,并非旨在表示不同标号的部件不能是相同或类似的。
具体实施方式
以下的详细描述引用了附图,附图构成实施方式的一部分,在附图中以示例的方式示出了装置、系统和使用的几种实施方式。可以了解的是,在不脱离本发明的范围和精神的情况下,其它实施方式也可以想到并做出的。因此,下面的详细描述不构成对本发明的限制。
这里所用的所有科技术语除非有特别的说明,都具有本领域的常用含义。此处的定义是为了便于理解这里经常用到的某些术语,并非意在限制本发明的范围。
如在本说明书和后附的权利要求中所用到的,单数形式的“一”和“该”包括具有多个所指物的实施例,除非内容清楚地表示其他含义。
如在本说明书和后附的权利要求中所用到的,用语“或”通常是指包括“和/或”的含义,除非内容清楚地表示其他含义。
如这里所用到的“具有”、“包含”、“包括”或类似的用语,是使用其开放式含义的,通常是指“包括,但不限于”的意思。
如这里所用到的,“长期”与监测相关,其表示在日、周、月或年的过程内一直在进行监测。长期监测可以包括持续地、定期地、间歇地或类似的在监测发生的时间范围内的感知。
如这里所用到的,“液体量”可以涉及组织液体量或血液液体量。
如这里所用到的,“组织液体量”表示患者的组织或部位内的液体(相对于细胞或固体)的量,患者的组织或部位可以是患者的整个身体。组织“液体”经常被称为间质液。在各实施例中,组织液体量、组织液体量的变化率以及诸如此类中的一个或多个,或者其指标根据本案的教示被监测。
如这里所用到的,“血液液体量”表示相对于血液中的细胞或固体,液体所占血液量的量或百分比。在各实施例中,血液液体量、血液液体量的变化率以及诸如此类中的一个或多个,或者其指标根据本案的教示被监测。
如这里所用到的“血液液体清除治疗”或类似语是指一个从病人的血液里将液体清除再将血液送回到病人体内的过程。在大多数情况下,血液也被净化,即从血液中清除废物,被净化的血液返回到病人体内。血液液体清除治疗的实例包括超滤、血液过滤、血液透析、血液透析滤过、腹膜透析等等。任何需要进行血液液体清除的病人都可以从这里所描述的装置、系统以及使用中受益。
如这里所用到的“需要进行一血液液体清除治疗的病人”是一已经接受、正在接受或可能会接受至少一个血液液体清除阶段的病人。通常,这些病人是液体负荷过多的病人,比如患有心力衰竭、慢性肾脏疾病或急性肾衰竭的病人。通常这些病人是慢性肾脏疾病第3期至第5期的病人,对利尿剂无反应或反应低等等。
除了其他以外,本文描述了对接受或可能需要接受液体清除治疗(例如血液透析,超滤法等)的患者的液体量进行长期监测的装置、系统和使用。通过提供何时进行治疗干预的处方,或是帮助做出在一个特定的治疗阶段中的液体清除速率和液体清除量的一适宜的决定,该长期监测可以改善此类患者的治疗或疗效。任何适当的监测或传感器装置均可被采用。
在一些实施方式中,且根据图1和图2,用于长期监测的传感器200或其部件是可穿戴的(图1)或可植入的(图2)。在图1所示的实施例中,传感器200显示为一带状的装置,其可以环绕于患者10的腰部穿戴。当然,传感器200或其部件可以构造为穿戴于患者10身体的任何适当部位。例如,传感器200设备构造为环绕着手腕或脚踝工作,可被系于手指或脚趾等诸如此类的部位上。在图2所描述的实施例中,传感器200及其部件201,205,207被植入患者10的腹部。当然,传感器200或其部件201,205,207也可以被植入其他适宜的部位,该部位从患者舒适的角度和实现传感器功能的技术角度都是可行的。如图2所示,该可植入的传感器200优选地被构造为与患者10体外的装置,或是其他植入的装置进行通信连接(例如无线地)。
无论传感器200是可穿戴的还是可植入的,传感器200都最好包括一电源,以使患者可以进行日常活动而无需将传感器200插在插座上。适当电源的实施例包括一电池,一耦合电容或诸如此类的,其中电池可以是可充电的。
为了阐述本技术方案,图3显示了一可植入的传感装置200的选定的部件的框图。所示的传感装置200具有一壳体299,其内具有多个部件,包括电源297,电子控制装置295,探测器电路296,指示器电路287以及遥测电路289。在图示的实施例中,该探测器电路296可操作地与探测器205耦合,该探测器电路296可以包括模数转换器,带通滤波器以及诸如此类,探测器205可以设于壳体299外,并与探测器电路296通过导线207耦合。探测器电路296可操作地与电源297和电子控制装置295耦合,电子控制装置295包括一处理器294和一存储器293,该存储器293用于存储获得的所感测的数据和处理器指令。电子控制装置也可操作地与电源297耦合,电源297可以为电池或是类似部件,电子控制装置还与遥测电路289耦合,以实现其与置于患者体外的装置或是其他植入装置的无线通信连接。遥测电路296使得传感器装置200可以向另一个装置传输关于液体量监测指标的数据。遥测电路296可以包括一遥测天线或本领域内技术人员熟知的其他适用于传输或接受数据的部件。指示器电路287可操作地与电源297和电子控制装置295耦合,当液体量接近一需要进行治疗干预的水平时,电子控制装置295可激发指示器电路287以提供一可感知的提示。指示器电路287可以包括提供一听觉信号的微型扬声器或是一个警示患者的振动机构。例如,如果液体量被确定为超出了一阈值,或者液体量的增加速度超出了一阈值,患者就会被警示其可能需要进行治疗干预。可以理解的是,除附图所示的以外,传感器200可以包括如本领域内技术人员所知晓的其他部件。在一些实施例中,如果超出了阈值,传感器200,经由遥测电路287,通过向患者程序器,患者控制器,手持式装置,电话,远程桌面装置等(例如,计算机,病床监视器,桌面监视器)传输信息,以警示医疗服务提供者。该信息可以从这些设备中的任意一种经由可接入的网络(无线,移动电话,有线等)传输给医疗服务提供者。
可以理解的是,可穿戴的传感器装置可以具有类似的部件,或是也可以构造为不同的结构。例如,有线通讯的通讯电路可以替代遥测电路,或与遥测电路并存。
在各种实施方式中,用于长期液体监测的传感器可用于监测血液液体量,或其一个指标。通常,传感器间接地测量液体量,并由此直接监测液体量的一个指标。例如,在一些实施例中,传感器间接监测红细胞比容(红细胞所占血液量的部分)。任何适宜的红细胞比容传感器,如HEMA METRICS公司的CRIT–LINE监测器(参见HEMA METRICS,CRIT–LINE红细胞比容的准确性,卷1,技术指引No.11(修订版D),2003年2月24日)[HEMAMETRICS,CRIT-LINE hematocrit accuracy,Vol.1,Techn Note No.11(Rev.D)February 24,2003)],均可以用于或经过修改后用于本案所述或可想到的装置或使用中。一个健康的成年男性的典型红细胞比容水平约在40%到54%之间,或约为47%,一个健康的成年女性的典型红细胞比容水平约在37%到47%之间,或约为42%。随着患者的肾病进展状态,或在血液液体清除阶段之前,患者的液体量可能会升高,因此红细胞比容水平可能会比期望的低。
因此,红细胞比容水平或红细胞比容水平的一近似值或指标可以用于监测血液液体量。在一些实施例中,血红蛋白水平作为红细胞比容水平和血液液体量的一指标而被监测,因为血红蛋白的浓度通常是与红细胞的浓度成比例的。任何适当的传感器都可以用来测量血红蛋白的浓度,例如脉搏血氧计使用的传感器,脉搏血氧计通过测量红光和红外光的吸附来分别确定氧合血红蛋白和脱氧血红蛋白的浓度。在一些实施例中,传感器可以夹在患者的手指上,并且可采用脉搏血氧计技术来检测作为血液液体量的一个指标的血红蛋白水平。当然,传感器(可包括相关联的光源)可设置于任何适当的位置,例如环绕管道设置,该管道为从患者向血液液体清除装置或是从血液液体清除装置向患者输送血液的管道,或是设置在血液清除装置内等。在一些实施例中,传感器被植入患者体内,并设置在血管附近以测量血红蛋白水平以及由此的红细胞比容和血液液体水平。
通过举例的方式,图4显示了一传感器200和管道300的示意图,管道300可以是血管。适当波长(红光或红外光)的一光源213设于管道300的一侧,以使光穿过管道300到达探测器215。如果管道300中的血红蛋白浓度高,则被吸收的光也更多(到达探测器215的光更少)。导线212,如果适宜,从传感器装置本体211向光源213传输电和其他电信号,传感器装置本体211可能包括电源和其他电子控制或检测装置。导线217从探测器215向设于传感器装置本体211内的部件传输电信号。
不管传感器200设于何处,传感器可以根据监测流过管道300(不论是血管还是血液液体清除装置采用的管道)的具有已知红细胞比容水平的血液流动来进行校准。获得的值可被存储在查找表中,在血液液体清除阶段期间或在使用传感器的其他需要情况下以供参考。在一些实施例中,当患者的血液处于理想的液体水平时,参考信号可能会被重置,或是在血液液体净化阶段后得到。在一些实施例中,血液液体量的变化率可以通过比较光吸收率的变化率来确定,例如,随着一血液液体净化阶段之后的血液液体量的增加,或是随着患者病情的恶化。
上文关于血红蛋白感测的讨论用于示例根据本文的教示,在本案所涉及的血液液体监测中,如何使用已知的感应技术和部件。可以理解的是,其他技术和部件也可用于监测血液液体量。例如,血中总蛋白或白蛋白浓度,以及血压,其中一个或其组合可用于评估血容量(blood volume)。举例来说,高血压结合低红细胞比容或低血蛋白表示了血液液体很可能过多。可替代地或另外地,血粘度可以作为血液液体量的一个指标,其可通过测量压力或流动得到。
在各种实施例中,用于长期液体监测的传感器可用于监测组织液体量或其一指标。可以采用任意适宜的传感器。举例来说,经过一患者的一组织的流体流动阻抗可以作为组织内液体量的一个指标进行监测。参见图5和图6,阻抗传感器200可以是外置的(图5)或是可植入的(图6)。随着组织内液体量的上升,阻抗会降低。可以了解的是,也可以采用电容,介电常数以及其他类似的测量参数,因为这些参数与液体量相关,并进一步与阻抗相关。基于本案的目的,监测与阻抗相关的组织的电性能被认为归于监测“阻抗”的定义内。
如图5所示,可以监测两个电极203,205之间的阻抗。电极203,205可操作地与电子控制和处理装置201通过导线耦合。电子控制和处理装置201被构造为在电极203,205之间产生一电压差,电流就可以测量出来,阻抗也可以计算出来。测量可以在直流或交流模式下进行。阻抗或相角可能与组织液体量相关。根据本文的教示,可以采用适宜的外部阻抗监测器200及部件,在本领域内是已知的并被记载于本领域内。
在图6所示的实施例中,一包含有电子控制装置201的导电壳体作为电极205的一参比电极。监测在组织内壳体和电极205之间的阻抗。电极205通过导线207与电子控制装置201耦合。如图6所示,电子控制装置201被构造为与患者体外的一装置无线通信连接,用以传输与监测到的阻抗有关的数据。
用于监测组织液体量的组织阻抗检测是有据可查的。本案可以采用的或经过修改后可以采用的一个已被详细了解的系统的例子,是美敦力公司的液体状态监测系统。这样一个系统或其他类似的系统具有详细记载的、用于确定组织阻抗和由此的液体量的可接受范围的程序。参见,例如(i)Siegenthalar等,《临床监测和计算杂志》(2010):24:449-451;以及(ii)Wang,AM.J.,《心脏病学》,99(增刊):3G-1-G,2007年5月21日[(i)Siegenthalar,et al.Journal of Clinical Monitoring and Computing(2010):24:449-451,and(ii)Wang,Am.J.Cardiology,99(Suppl):3G-l-G,May 21,2007.]。可替代地或另外地,可在一段适当的时间内监测组织的阻抗以建立适宜的基线,患者的标记或临床医生的输入也可用于处方患者的液体是过多还是不足。获取自阻抗传感器的数据以及输入数据可用于建立阻抗值的适宜范围,该输入数据是关于在获得传感器数据时患者的液体状态的。
在一些实施例中,可以采用一个以上的植入阻抗传感器,如采用一个以上的液体状态监测系统。该传感器可以被构造为或设置为监测不同组织的阻抗,同一组织不同区域的阻抗,或诸如此类的。在传感器失效或用于对另一个传感器获得的读数进行核查的情况下,重复设置的传感器会提供重复数据。在某些情况下,传感器检测到的组织液体的变化可能是由于慢性心脏衰竭或肾病以外的原因。例如,可能由肺炎导致的肺部液体增加。这种液体未必能表示需要进行血液液体清除阶段。通过设置一用于监测例如腹部液体的第二阻抗传感器,可对设置和构造为监测肺部液体量的传感器进行检查。这些传感器可以被构造为彼此之间进行通信连接或是与另一个装置进行通信连接,以确定传感器读数是否具有显著差别或者该差别是否超出了一阈值,在这种情况下,可能会提示患者寻求医疗看护。使用一个以上阻抗传感器对降低假阳性或假阴性的液体过剩情况的可能性应该是有价值的。
上文关于阻抗监测的讨论用于示例,根据本文的教示,在本案所涉及的组织液体监测中,如何使用已知的感应技术和部件。可以理解的是,其他技术和部件也可以用于监测组织液体量。例如,采用离子选择电极可在一组织内测量电解质(诸如钠,钾,钙)的浓度,组织液体量越低其浓度越高。进一步举例来说,可在组织内设置一压力传感器以测量在液体量变化时的组织的舒张或收缩,可采用应力与应变传感器测量模量或组织的应力-应变曲线,应力与应变传感器还可用于将不同的组织液体量关联起来,组织的应力松弛或蠕变图谱是可以测得的,并且可与不同液体量等相关联。间接监测组织液体量的另一个例子是测量肺部噪声,由于气流阻抗,在液体过多时,肺部噪声倾向于变大。
不论所采用的传感器或传感器构造是怎样的,也不论传感器是构造为监测血液液体还是组织液体,传感器数据均可用于改善液体过剩患者(例如慢性肾病患者)的治疗或疗效。在各种实施方式中,传感器数据可用于帮助确定创建瘘管的时间。在一些实施例中,传感器数据可用于帮助确定血液液体清除阶段的一适当的液体清除量处方(prescription)(例如,液体清除的量和速率或液体清除图谱)。在一些实施例中,传感器数据可在血液液体清除治疗阶段中使用,如临时申请号为61/480,528,名称为“慢性肾病患者的液体量监测”,代理人案号为P0041416.00,申请日与本案相同的美国临时专利申请中所描述的。该临时专利申请与本案公开内容不相矛盾的部分在本案中被全文引用。
现参见图7-图9,其显示了本案所述的液体量的长期监测的使用实施例的概况。在一些实施例中,该使用可用于帮助确定创建一瘘管的适当时机。例如,可以监测液体量的一指标(例如,如上文所讨论的)500,做出一关于该指标是否超出了一预定阈值的决定510,例如一表示过多液体水平的阈值,当达到该过多液体水平时需要创建一瘘管。该阈值可以是基于收集自根据现有的医疗实践被密切监测的全体患者的经验数据,还可以是基于给定患者的基线的变化,或诸如此类的。如果被监测的指标超出了表示增加的流体的一阈值,可以提供一警报520,例如,如上文所述的传感器的一指示器电路提供一警报。该传感器还可以安排一与医疗服务提供者的约会,或存储和通过一外部装置(如程序器(programmer),计算机,个人数据助手,平板电脑等等)向一医疗服务提供者传输关于液体量的监测指标的数据。
在一些实施例中,图7-图9所示的使用可以用于确定一心力衰竭患者是否将要进行代谢失调。关于患者在先的代谢失调期间或代谢失调之前的液体水平的数据可以被标记或评估。举例来说,医生或医疗服务提供者可以询问一液体监测装置,以更好地了解表现有心力衰竭代谢失调症状的患者就诊之前的情况。警报阈值可以根据监测到的患者就诊之前的液体水平、速率等进行调整。在一些实施例中,监测装置或包括监测装置的系统可以接收关于病人代谢失调状态的输入,且该装置或系统可能会审核存储于存储器中的数据,以确定是否出现了代谢失调的某些症状。发出警报的阈值可以由该装置或系统自动调整。
如图8所示,一种使用包括根据监测到的指标确定液体的增加速率是否超出了一预定的阈值530。如果液体量增加的速率高于或超出了一阈值,就可以发出警报(等)。在一些实施例中,在确定全部指标的值是否超出了一阈值510之前,希望可以确定速率是否超出了一阈值530,因为如果增加的速率高了,所有的阈值会较之速率低时要低。也就是说,阈值510可能是基于速率530的。
如图9所示,一种使用可包括确定监测到的指标是否超出了第一高阈值510,在此情况下,发出一警报(等)520。如果指标没有超出该第一高阈值510,就确定所感测的数据表示的液体增加的速率是否超出了一阈值530。如果增加的速率超出了一阈值,确定监测到的指标的值(因为其表示液体量)是否超出了一个较低的第二阈值540。在这种情况下,发出警报(等)520。用这种方法,如果增加的速率高,就可能设定一个较低的阈值。该阈值可被输入到基于来自于其他患者或人群的现有数据的查找表格中,或者可以基于在患者体内获得的感测到的数据而“获知”。
应该理解的是,在图7-图9中所描绘的以及与图7-图9相关的所描述的使用对于已经接受血液液体清除治疗的患者是有用的,且可用于自动安排液体清除阶段(例如,图9中的590),例如,通过如上文所述的遥测电路。一监测液体量的指标的传感器也可以根据所感测的数据计算出一液体量处方(例如,图9中的591),并向一液体清除量装置或其他装置传输关于该处方的数据,该液体清除装置或其他装置将允许一医疗服务提供者输入适宜的液体清除量处方。可替代地或另外地,关于所监测的指标的数据可以被传输到一液体清除量装置或其他装置,然后该液体清除量装置或其他装置基于所传输的数据可以计算出一适当的液体清除量处方(例如,图9中的591)。该液体清除量的处方数据可以由传感器装置或其他装置根据其他患者或人群的现有数据而计算出来,或者基于随着时间在患者体内获得的感测到的数据而“获知”。
任何用于从血液中清除液体或液体和污物的适宜装置或系统均可根据本案的教示使用。该装置或其部件可以是传统的大型顾问型、可穿戴的、可植入的,或诸如此类的。
图1-图4显示了血液液体清除装置和系统的一些实施例的框图。如图10所示,血液可以从患者10体内流出,且液体可以通过一血液液体清除装置100被清除,然后回到患者10体内。被清除的液体可以被转移。在一些血液液体清除装置100或系统或其部件是植入式的实施例中,被清除的液体可以被转移到患者的膀胱。可以如图10所示的操作的血液液体清除装置100的实例是超滤和血液过滤装置。根据本案的教示可以采用这样的装置和其部件的实例,在本技术领域内是已知的。可以理解的是,也可以采用透析液被引入腹膜腔的腹膜透析。
采用一些这样的装置,液体清除的速率可能太快。因此,参见图11,可以将置换液引入患者的血液中。如图11所示,可以在液体清除之前将置换液加入到原始血液中,也可以在初始液体清除之后、流返至患者心血管系统之前,将置换液加入到原始血液中。优选地,该置换液在初始液体清除之后被加入。
如图12所描绘的实施例所示,血液液体清除装置100可以采用透析液来辅助从患者的血液中去除污物,并辅助维持适当的pH值和电解质平衡。使用过的透析液和从血液中清除的液体可以被转移。在一些实施例中,特别是血液液体清除装置100或系统或其部件是可穿戴的或可植入的实施例中,使用过的透析液和被清除的液体,或其一部分,可以被再生为新鲜的透析液,该新鲜的透析液可以在血液液体清除过程中再次使用。再生透析液的一种系统是REDY系统,如Roberts,M,“再生透析(REDY)吸附剂系统”《肾脏病学》4:275-278,1998年所描述的(Roberts,M,"The regenerative dialysis(REDY)sorbent system,"Nephrology 4:275-278,1998),该系统可以用于或经过简单的修改后用于本文所描述的实施例。按照图12所示的实施例操作的系统和设备包括血液透析和血液透析滤过系统。根据本案的教示可以采用这样的装置和其部件的实例,在本技术领域内是已知的。
如图13所示,当图12所示的血液液体清除装置以过高的速率将液体从血液中清除时,可以在液体清除的上游或下游将置换液引入患者的血液。
不论采用的装置或血液液体清除过程是怎样的,控制液体清除的量和速率以避免血液液体被清除的患者发生严重的低血压、心力衰竭或突发的心脏死亡是很重要的。为了效率的目的,控制液体清除的量和速率也是很重要的。也就是说,即使非常缓慢的清除液体通常是更安全的,但是如此缓慢的清除会导致血液液体清除阶段持续相当长的时间。尽管当血液液体清除系统是可穿戴的或可植入时,如此缓慢的清除是可以接受的,但是当血液液体清除系统是大型独立的系统而需要患者去医院就诊时,如此缓慢的清除是不能被接受的。通常患者的生活质量已经很低了,让其长期呆在医院可能会使其痛苦,而长期呆在医院对于从血液中缓慢清除液体的系统又是必要的。理想地,血液液体清除装置或系统通过控制液体清除的速率来平衡健康问题和效率问题。
当然,液体清除的量对于维持患者的健康也是很重要的变量。如果清除的液体过少,或患者会担负过多的液体,从而会导致心力衰竭、高血压或其他失调,直到其下一次血液液体清除阶段或是其液体清除处方被改变。如果清除的液体过多,患者可能会发生低血压、病危、心脏猝死,或诸如此类。因此希望,不仅以一可接受的速率,还以一可接受的量从血液中清除液体。
在一些实施例中,用于液体量指标的长期监测的从传感器获得的数据(例如,如上文所述的),可以用于使初始液体清除量处方比目前使用的数据更加精确和可靠,目前使用的数据是基于干体重(其可能经常几天或几周从一给定的液体清除阶段确定)的。在一些实施例中,传感器数据可以在一血液液体清除过程中使用,如名称为“肾病患者的液体量监测”,申请日与本案相同,代理人案号为P0041416.00的第61/480,528号美国临时专利申请中所描述的。
现参见图14,其显示了一血液液体清除装置100的选定部件的示意框图。在该描绘的实施例中,该装置具有一用于接受来自患者的血液的内置入口110,一血液流量控制元件120,其与入口110通信连接并构造为控制血液流经中间装置130的速率以将液体和污物从血液中清除。该装置还包括一与中间装置130通信连接的出口140,以使血液流返至患者。在所描绘的实施例中,中间装置130包括一半渗透的过滤膜(filter)135,例如一血液透析或血液透析滤过过滤膜。该膜将血液流动腔与中间装置130的透析液流动腔分隔开来。装置100具有一接收新鲜的透析液的入口160。入口160与一透析液流量控制元件170通信连接,该透析液流量控制元件170用于控制透析液被引入中间装置130的透析液流动腔的速率。该装置还具有一与中间装置130通信连接的出口180,该出口用于将使用过的透析液和从血液中清除的液体移出装置外。在所描述的实施例中,根据需要或期望的,该装置还包括一与中间装置130的透析液流动腔通信连接的负压调节元件190。装置100还包括电子控制装置150,其可以包括一处理器、存储器等,该电子控制装置150优选地与血液流量控制元件120、透析液流量控制元件170和负压调节元件190耦合,并构造为对其进行控制。
根据接收自监测血液液体量或组织液体量的传感器的信息,电子控制装置150可以控制血液流量控制元件120(例如根据计算出的液体清除量处方),透析液流量控制元件170和负压调节元件190中的一个或多个,以调整从患者的血液中清除液体的速率。例如,改变流经中间装置部件130的血液的流动速率(通过血液流量控制元件120)可以改变穿过膜的液体清除率。改变经过中间装置130的透析液的流动(通过透析液流量控制元件170)可以同样改变通过膜的液体清除率。可以在膜135的透析液腔一侧施加负压(通过负压调节元件190),并可能会由于对流力导致更大的穿过膜的液体清除率。可以理解的是,根据接收自传感器监测组织液体量和血液液体量的指标的数据,要有效地控制从血液中清除液体的速率,装置100不必具有图15所描绘的所有控制元件120,170,190。
任何适宜的血液流量控制元件120可以用于控制经过膜部件130的血液流动。例如,可以采用一可调速率泵或可变速率泵。可替代地或另外地,可以采用一系列与流动路径相连通的电控阀,其对于流动具有不同的阻力(在此情况下,限流器优选地设于中间装置部件130的下游)。透析液流量控制元件170可以包括类似的部件,或具有与血液流量控制元件120类似的构造。负压调节元件190可以包括一泵或诸如此类。
现参见图15,在图15中,与图14相同的标号表示相同或类似的部件,装置100可包括一在血液流返至患者之前向血液中加入置换液的液体路径。该装置100包括一接收置换液的入口197以及一置换液流量控制元件195,该置换液流量控制元件195与入口通信连接,并被构造为控制向血液中添加置换液的速率。电子控制装置150可操作地与置换液流量控制元件195耦合,并被构造为根据接收自监测血液液体量或组织液体量的传感器的数据,控制置换液流量控制元件195向血液中加入置换液的速率。通过控制液体被引入到血液中的速率,从血液中有效清除液体的速率是可控的。
任何适宜的置换液流量控制元件195都可以用于在血液流返至患者之前对向血液中加入的置换液的流动进行控制。置换液流量控制元件195可以包括类似元件,或如上文关于图15的描述,与血液流量控制元件120具有类似的构造。
正如上面所讨论的以及如图16所示的,一个或多个传感器装置200,210,220或传感部件可与血液清除装置100或系统的电子控制装置150通信连接。该通信连接可以是直接或间接的。也就是说,一探测器和适宜的电子装置(例如滤波器,模数转换器等)可直接与装置100的电子控制装置150通过导线耦合。可替代地,一传感器可以获得监测数据,并将监测数据传输到装置的电子控制装置150。在任何情况下,该电子控制装置被配置为根据感测到的信息,例如,如上文所述的(例如根据计算出的液体清除量处方),控制从血液中清除液体的速率。
在一些实施例中,一计算机可读介质具有使得电子控制装置的处理器(传感器或液体清除量装置的)执行上述使用的指令,例如上文与图7-图9相关的所描述和所描绘的使用。
当然,在数据被输送到血液液体清除装置或系统之前,传感器可以与一个或多个中介装置通信连接,以根据本文的教示使用该数据控制从血液中清除液体的速率。
本文对装置、系统、使用、计算机可读介质等的各个方面均做出了描述。其中的一些方面被归纳如下:
在一第一种情况中,一种使用包括:通过一可植入的传感器装置监测一患者的一液体量指标;并根据监测到的液体量指标为一血液液体清除阶段设定一初始液体清除量处方。
第二种情况是第一种情况的一使用,其进一步包括向液体清除装置输送关于来自于可植入的传感器装置的液体量指标的数据。
第三种情况是第二种情况的一使用,其中设定该初始液体清除量处方包括:通过液体清除装置根据接收自可植入的传感器的数据计算液体量处方。
第四种情况是第一至第三种情况中任意一种的一使用,其中液体量指标是一组织液体量指标或是一血液液体量指标。
第五种情况是第一至第四种情况中任意一种的一使用,其中液体量指标是组织阻抗或血液的红细胞比容。
第六种情况是第一至第五种情况中任意一种的一使用,其中液体量指标是组织阻抗。
第七种情况是第一至第六种情况中任意一种的一使用,其进一步包括:确定液体量指标是否超出了一预定的阈值,并在确定了液体量指标超出该阈值的情况下,向患者发出一警报。
第八种情况是第七种情况的一使用,其进一步包括:如果该指标超出了阈值,通过将来自于传感器的一信号经由一中介装置传输至一医疗服务提供者来自动安排一血液液体清除阶段。
第九种情况是第一种情况的一使用,其中监测液体量指标包括监测一组织液体量指标,该使用进一步包括监测一血液液体量指标,其中根据监测到的血液液体量指标为血液液体清除阶段设定初始液体清除量处方包括:根据监测到的组织液体量指标和血液液体量指标的比值设定初始液体清除量处方。
第十种情况是第一种情况的一使用,其中监测液体量指标包括监测一血液液体量指标,该使用进一步包括监测一组织液体量指标,其中为血液液体清除阶段设定初始液体清除量处方包括:根据监测到的组织液体量指标和血液液体量指标的比值设定初始液体清除量处方。
第十一种情况是一系统,其包括:(a)一构造为监测一液体量指标的传感器;以及(b)一血液液体清除装置;该血液液体清除装置包括:(i)一入口,用于接收来自于一患者的血液;(ii)一将来自于患者的血液送回的第一出口;(iii)一用于从血液中清除液体的中间装置,该中间装置设于入口和第一出口之间;(iv)一液体清除速率控制器;(v)一第二出口,用于清除液体的流出;以及(vi)与液体清除速率控制器和传感器耦合的电子装置,该电子装置构造为根据接收自传感器的数据设定一初始液体清除速率处方,并根据设定的初始液体清除速率处方控制液体清除速率控制器。
第十二种情况是第十一种情况的一系统,其中传感器是可植入的。
第十三种情况是第十一种情况的一系统,其中传感器是可穿戴的。
第十四种情况是第十一至第十三种情况中任意一种的一系统,其中电子装置包括一计算机可读介质,该计算机可读介质在执行时,使得该电子装置根据接收自传感器的数据计算初始液体清除速率处方,并指令液体清除速率控制器根据初始液体清除速率处方进行操作。
第十五种情况是第十一或第十四种情况的一系统,其中传感器和液体清除装置是可植入的。
第十六种情况是第十一或第十四种情况的一系统,其中传感器和液体清除装置是可穿戴的。
第十七种情况是第十一至第十六种情况中任意一种的一系统,其中电子控制装置设于血液液体清除装置的一壳体内。
第十八种情况是一可植入装置实施的一使用,其包括:(i)监测慢性肾病患者的液体量指标,其中该监测至少部分地由一可植入的传感器装置实施;(ii)确定监测到的液体量指标是否超出了一预定的阈值;以及(iii)当监测到的指标确定超出了该阈值时,向患者发出一可感知的警报。
第十九种情况是第十八种情况的一使用,其进一步包括:如果监测到的指标确定超出了该阈值,自动安排一血液液体清除阶段。
第二十种情况是一系统,其包括:(a)一可植入的传感器装置,其构造为监测一患者的组织阻抗,该装置包括:(i)一第一电极;(ii)一第二电极;(iii)可操作地与第一电极和第二电极耦合的电子装置,以监测两个电极之间的流体流动阻抗;以及(iv)一第一通信电路,其构造为传输关于监测到的阻抗的数据;(b)一液体清除装置,用于从一患者清除液体,该装置包括:(i)一入口,用于接受来自于患者的血液;(ii)一用于将液体从血液中清除的中间装置,该中间装置与入口通信连接;(iii)一用于将血液送回患者的出口,其与中间装置通信连接;(iv)一流量控制器,其与入口、出口和中间装置通信连接,该流量控制器构造为控制液体从中间装置清除出的速率;(c)一第二通信电路,其构造为无线接收关于阻抗的数据,该关于阻抗的数据来自于可植入的装置;以及(d)与第二通信电路和流量控制器通信连接的电子装置,其中电子装置构造为:根据在液体清除阶段开始之前接收的阻抗数据为液体清除阶段设定一初始液体清除处方,并根据接收到的阻抗数据控制与液体清除速率有关的流量控制器。
第二十一种情况是第二十种情况的一系统,其中液体清除装置的电子装置构造为:在一液体清除阶段期间,根据阶段期内接收到的阻抗数据,改变初始液体清除速率或图谱。
第二十二种情况是第二十或二十一种情况的一系统,其中液体清除装置是可植入的,且传感器装置的第一通信电路和液体清除装置的第二通信电路是同一电路。
第二十三种情况是第二十至第二十二种情况中任意一种的一系统,其中电子控制装置设于血液液体清除装置的一壳体内。
第二十四种情况是一传感器装置,其包括:(i)一探测器电路和部件,其构造为获得一感测到的关于液体量指标的数据;以及(ii)电子控制装置,其构造为从探测器电路接收获得的感测到的数据,并根据获得的感测到的数据计算一液体清除量处方。
实例
下列预示的实例用于为如何获得和翻译来自一可植入传感器的数据提供指导,该可植入的传感器构造为用于在如上述具体实施方式中描述的使用或装置中测量患者的组织液体量。可以理解的是,此处提供的符合本案一般原则的预示实例,只是用于获得和翻译监测到的数据的一种适当的方式。
对于这个预示的实例来说,一可植入的组织阻抗传感器,如美敦力公司的液体状态监测系统,被植入患者体内,以在装置的壳体和通过一导线从壳体中伸出的一电极之间测量组织阻抗。已经建立了有详细记载的用于确定组织阻抗及液体量的可接受范围的程序。参见,例如,(i)Siegenthalar,等人,《临床监测与计算杂志》(2010):24:449-451(Siegenthalar,et al.Journalof Clinical Monitoring and Computing(2010):24:449-451),以及(ii)Wang,AM.J.,《心脏病学》,99(增刊):3G-I-G,2007年5月21日(Wang,Am.J.Cardiology,99(Suppl):3G-l-G,May 21,2007)。这些使用可以替代地或者组合地采用,可以在一适宜的时间段内监测组织阻抗以建立合适的基线,并且患者标记或临床医生的输入也可以用于处方患者的液体是过多还是过少。阻抗传感器获得的数据以及关于患者在获得传感器数据期间的液体状态的输入数据,可以用来建立阻抗值的适宜范围。该传感器可以通过传输的数据被不时地重新校准,该传输的数据是关于已确诊患者的液体状态的,例如,根据一身体检查结果。
一旦该传感器被正确校准,其关于组织阻抗(其与液体量相关)的读数就是可信的。然后这些读数就可以根据本文的教示被可靠地使用。
因此,肾病患者的液体量监测的系统、装置和使用均已被描述。本领域内的技术人员应当知晓本文描述的优选实施例在不背离本案的权利要求所限定的实质精神和范围的情况下,是可以变化和修改的。
Claims (4)
1.一种监测肾病患者的液体量的系统,其包括:
(i)一可植入的传感器装置,其构造为监测组织阻抗,该装置包括:一第一电极;一第二电极;可操作地与第一电极和第二电极耦合的电子装置,以监测两个电极之间的流体流动阻抗;以及一第一通信电路,其构造为传输关于监测到的阻抗的数据;
(ii)一液体清除装置,用于清除液体,该装置包括:一入口,用于接受血液;一用于将液体从血液中清除的中间装置,该中间装置与入口通信连接;一用于将血液送回的出口,其与中间装置通信连接;一流量控制器,其与入口、出口和中间装置通信连接,该流量控制器构造为控制液体从中间装置清除出的速率;
(iii)一第二通信电路,其构造为无线接收关于阻抗的数据,该关于阻抗的数据来自于可植入的传感器装置;以及
(iv)与第二通信电路和流量控制器通信连接的电子装置,其中电子装置构造为:根据在液体清除阶段开始之前接收的阻抗数据为液体清除阶段设定一初始液体清除处方,并根据接收到的阻抗数据控制与液体清除速率有关的流量控制器。
2.如权利要求1所述的系统,其中液体清除装置的电子装置构造为:在一液体清除阶段期间,根据本阶段内接收到的阻抗数据,改变初始液体清除速率或图谱。
3.如权利要求1所述的系统,其中液体清除装置是可植入的,且传感器装置的第一通信电路和液体清除装置的第二通信电路是同一电路。
4.如权利要求1所述的系统,其中电子控制装置设于血液液体清除装置的一壳体内。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510593695.3A CN105286787B (zh) | 2011-04-29 | 2012-04-19 | 肾病患者的液体量监测 |
Applications Claiming Priority (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161480532P | 2011-04-29 | 2011-04-29 | |
US201161480544P | 2011-04-29 | 2011-04-29 | |
US201161480539P | 2011-04-29 | 2011-04-29 | |
US201161480528P | 2011-04-29 | 2011-04-29 | |
US201161480535P | 2011-04-29 | 2011-04-29 | |
US201161480541P | 2011-04-29 | 2011-04-29 | |
US201161480530P | 2011-04-29 | 2011-04-29 | |
US61/480,530 | 2011-04-29 | ||
US61/480,528 | 2011-04-29 | ||
US61/480,539 | 2011-04-29 | ||
US61/480,535 | 2011-04-29 | ||
US61/480,544 | 2011-04-29 | ||
US61/480,541 | 2011-04-29 | ||
US61/480,532 | 2011-04-29 | ||
US13/424,467 US8926542B2 (en) | 2011-04-29 | 2012-03-20 | Monitoring fluid volume for patients with renal disease |
US13/424,467 | 2012-03-20 | ||
PCT/US2012/034329 WO2012148785A2 (en) | 2011-04-29 | 2012-04-19 | Monitoring fluid volume for patients with renal disease |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510593695.3A Division CN105286787B (zh) | 2011-04-29 | 2012-04-19 | 肾病患者的液体量监测 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103747817A CN103747817A (zh) | 2014-04-23 |
CN103747817B true CN103747817B (zh) | 2016-10-12 |
Family
ID=47067087
Family Applications (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201280020933.6A Active CN103747816B (zh) | 2011-04-29 | 2012-04-19 | 液体清除治疗的心血管监测系统 |
CN201510511657.9A Active CN105169509B (zh) | 2011-04-29 | 2012-04-19 | 液体清除治疗的电解质和pH值的监测 |
CN201280020938.9A Active CN103747731B (zh) | 2011-04-29 | 2012-04-19 | pH值或电解质的长期监测 |
CN201280020932.1A Active CN103717132B (zh) | 2011-04-29 | 2012-04-19 | 液体清除治疗的电解质和pH值的监测 |
CN201280022405.4A Active CN103717244B (zh) | 2011-04-29 | 2012-04-19 | 血液液体清除治疗阶段之间的监测 |
CN201510593695.3A Active CN105286787B (zh) | 2011-04-29 | 2012-04-19 | 肾病患者的液体量监测 |
CN201280022402.0A Active CN103747819B (zh) | 2011-04-29 | 2012-04-19 | 血液液体清除的自适应系统 |
CN201280020937.4A Active CN103747817B (zh) | 2011-04-29 | 2012-04-19 | 肾病患者的液体量监测 |
CN201280020931.7A Active CN103717243B (zh) | 2011-04-29 | 2012-04-19 | 肾病患者的液体量监测 |
CN201610315692.8A Pending CN106063701A (zh) | 2011-04-29 | 2012-04-19 | 血液液体清除治疗阶段之间的监测 |
Family Applications Before (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201280020933.6A Active CN103747816B (zh) | 2011-04-29 | 2012-04-19 | 液体清除治疗的心血管监测系统 |
CN201510511657.9A Active CN105169509B (zh) | 2011-04-29 | 2012-04-19 | 液体清除治疗的电解质和pH值的监测 |
CN201280020938.9A Active CN103747731B (zh) | 2011-04-29 | 2012-04-19 | pH值或电解质的长期监测 |
CN201280020932.1A Active CN103717132B (zh) | 2011-04-29 | 2012-04-19 | 液体清除治疗的电解质和pH值的监测 |
CN201280022405.4A Active CN103717244B (zh) | 2011-04-29 | 2012-04-19 | 血液液体清除治疗阶段之间的监测 |
CN201510593695.3A Active CN105286787B (zh) | 2011-04-29 | 2012-04-19 | 肾病患者的液体量监测 |
CN201280022402.0A Active CN103747819B (zh) | 2011-04-29 | 2012-04-19 | 血液液体清除的自适应系统 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201280020931.7A Active CN103717243B (zh) | 2011-04-29 | 2012-04-19 | 肾病患者的液体量监测 |
CN201610315692.8A Pending CN106063701A (zh) | 2011-04-29 | 2012-04-19 | 血液液体清除治疗阶段之间的监测 |
Country Status (6)
Country | Link |
---|---|
US (17) | US8951219B2 (zh) |
EP (10) | EP2701760B1 (zh) |
JP (11) | JP5837679B2 (zh) |
CN (10) | CN103747816B (zh) |
ES (1) | ES2785107T3 (zh) |
WO (8) | WO2012148789A1 (zh) |
Families Citing this family (286)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006086490A1 (en) | 2005-02-07 | 2006-08-17 | Medtronic, Inc. | Ion imbalance detector |
US9867530B2 (en) | 2006-08-14 | 2018-01-16 | Volcano Corporation | Telescopic side port catheter device with imaging system and method for accessing side branch occlusions |
WO2009009802A1 (en) | 2007-07-12 | 2009-01-15 | Volcano Corporation | Oct-ivus catheter for concurrent luminal imaging |
EP2178442B1 (en) | 2007-07-12 | 2017-09-06 | Volcano Corporation | Catheter for in vivo imaging |
US9596993B2 (en) | 2007-07-12 | 2017-03-21 | Volcano Corporation | Automatic calibration systems and methods of use |
US9399091B2 (en) | 2009-09-30 | 2016-07-26 | Medtronic, Inc. | System and method to regulate ultrafiltration |
EP2502115A4 (en) | 2009-11-20 | 2013-11-06 | Pelican Imaging Corp | RECORDING AND PROCESSING IMAGES THROUGH A MONOLITHIC CAMERA ARRAY WITH HETEROGENIC IMAGE CONVERTER |
US11141063B2 (en) | 2010-12-23 | 2021-10-12 | Philips Image Guided Therapy Corporation | Integrated system architectures and methods of use |
US11040140B2 (en) | 2010-12-31 | 2021-06-22 | Philips Image Guided Therapy Corporation | Deep vein thrombosis therapeutic methods |
US8951219B2 (en) | 2011-04-29 | 2015-02-10 | Medtronic, Inc. | Fluid volume monitoring for patients with renal disease |
US9456755B2 (en) | 2011-04-29 | 2016-10-04 | Medtronic, Inc. | Method and device to monitor patients with kidney disease |
US9132217B2 (en) | 2011-04-29 | 2015-09-15 | Medtronic, Inc. | Multimodal dialysis system |
US9848778B2 (en) | 2011-04-29 | 2017-12-26 | Medtronic, Inc. | Method and device to monitor patients with kidney disease |
EP3165245B1 (en) | 2011-08-02 | 2019-02-20 | Medtronic, Inc. | Hemodialysis system having a flow path with a controlled compliant volume |
EP2744537B1 (en) | 2011-08-16 | 2018-01-24 | Medtronic, Inc. | Modular hemodialysis system |
WO2013033489A1 (en) | 2011-08-31 | 2013-03-07 | Volcano Corporation | Optical rotary joint and methods of use |
WO2013043751A1 (en) | 2011-09-19 | 2013-03-28 | Pelican Imaging Corporation | Systems and methods for controlling aliasing in images captured by an array camera for use in super resolution processing using pixel apertures |
KR102002165B1 (ko) | 2011-09-28 | 2019-07-25 | 포토내이션 리미티드 | 라이트 필드 이미지 파일의 인코딩 및 디코딩을 위한 시스템 및 방법 |
US9713668B2 (en) | 2012-01-04 | 2017-07-25 | Medtronic, Inc. | Multi-staged filtration system for blood fluid removal |
EP2817955B1 (en) | 2012-02-21 | 2018-04-11 | FotoNation Cayman Limited | Systems and methods for the manipulation of captured light field image data |
EP2653178A1 (de) * | 2012-04-16 | 2013-10-23 | Zentrum für biomedizinische Technologie der Donau- Universität Krems | Sicherheitseinrichtung für eine extrakorporale Blutbehandlung |
US11871901B2 (en) | 2012-05-20 | 2024-01-16 | Cilag Gmbh International | Method for situational awareness for surgical network or surgical network connected device capable of adjusting function based on a sensed situation or usage |
KR20150023907A (ko) | 2012-06-28 | 2015-03-05 | 펠리칸 이매징 코포레이션 | 결함있는 카메라 어레이들, 광학 어레이들 및 센서들을 검출하기 위한 시스템들 및 방법들 |
WO2014032020A2 (en) | 2012-08-23 | 2014-02-27 | Pelican Imaging Corporation | Feature based high resolution motion estimation from low resolution images captured using an array source |
JP2015532536A (ja) | 2012-10-05 | 2015-11-09 | デイビッド ウェルフォード, | 光を増幅するためのシステムおよび方法 |
US9292918B2 (en) | 2012-10-05 | 2016-03-22 | Volcano Corporation | Methods and systems for transforming luminal images |
US10568586B2 (en) | 2012-10-05 | 2020-02-25 | Volcano Corporation | Systems for indicating parameters in an imaging data set and methods of use |
US9858668B2 (en) | 2012-10-05 | 2018-01-02 | Volcano Corporation | Guidewire artifact removal in images |
US9307926B2 (en) | 2012-10-05 | 2016-04-12 | Volcano Corporation | Automatic stent detection |
US9286673B2 (en) | 2012-10-05 | 2016-03-15 | Volcano Corporation | Systems for correcting distortions in a medical image and methods of use thereof |
US10070827B2 (en) | 2012-10-05 | 2018-09-11 | Volcano Corporation | Automatic image playback |
US11272845B2 (en) | 2012-10-05 | 2022-03-15 | Philips Image Guided Therapy Corporation | System and method for instant and automatic border detection |
US9367965B2 (en) | 2012-10-05 | 2016-06-14 | Volcano Corporation | Systems and methods for generating images of tissue |
US9324141B2 (en) | 2012-10-05 | 2016-04-26 | Volcano Corporation | Removal of A-scan streaking artifact |
US9840734B2 (en) | 2012-10-22 | 2017-12-12 | Raindance Technologies, Inc. | Methods for analyzing DNA |
WO2014078443A1 (en) | 2012-11-13 | 2014-05-22 | Pelican Imaging Corporation | Systems and methods for array camera focal plane control |
US10905816B2 (en) | 2012-12-10 | 2021-02-02 | Medtronic, Inc. | Sodium management system for hemodialysis |
EP2931132B1 (en) | 2012-12-13 | 2023-07-05 | Philips Image Guided Therapy Corporation | System for targeted cannulation |
JP2016506276A (ja) | 2012-12-20 | 2016-03-03 | ジェレミー スティガール, | 血管内画像の位置の特定 |
US10939826B2 (en) | 2012-12-20 | 2021-03-09 | Philips Image Guided Therapy Corporation | Aspirating and removing biological material |
CA2895502A1 (en) | 2012-12-20 | 2014-06-26 | Jeremy Stigall | Smooth transition catheters |
US9709379B2 (en) | 2012-12-20 | 2017-07-18 | Volcano Corporation | Optical coherence tomography system that is reconfigurable between different imaging modes |
DE102012025052A1 (de) * | 2012-12-20 | 2014-06-26 | Fresenius Medical Care Deutschland Gmbh | Hämodiafiltrationsverfahren |
US10942022B2 (en) | 2012-12-20 | 2021-03-09 | Philips Image Guided Therapy Corporation | Manual calibration of imaging system |
US11406498B2 (en) | 2012-12-20 | 2022-08-09 | Philips Image Guided Therapy Corporation | Implant delivery system and implants |
WO2014100579A1 (en) * | 2012-12-21 | 2014-06-26 | David Anderson | Functional gain measurement technique and representation |
US10191220B2 (en) | 2012-12-21 | 2019-01-29 | Volcano Corporation | Power-efficient optical circuit |
US9612105B2 (en) | 2012-12-21 | 2017-04-04 | Volcano Corporation | Polarization sensitive optical coherence tomography system |
US10332228B2 (en) | 2012-12-21 | 2019-06-25 | Volcano Corporation | System and method for graphical processing of medical data |
EP2934280B1 (en) | 2012-12-21 | 2022-10-19 | Mai, Jerome | Ultrasound imaging with variable line density |
CA2895940A1 (en) | 2012-12-21 | 2014-06-26 | Andrew Hancock | System and method for multipath processing of image signals |
EP2936626A4 (en) | 2012-12-21 | 2016-08-17 | David Welford | SYSTEMS AND METHODS FOR REDUCING LIGHT WAVE LENGTH TRANSMISSION |
US10058284B2 (en) | 2012-12-21 | 2018-08-28 | Volcano Corporation | Simultaneous imaging, monitoring, and therapy |
WO2014100606A1 (en) | 2012-12-21 | 2014-06-26 | Meyer, Douglas | Rotational ultrasound imaging catheter with extended catheter body telescope |
US10413317B2 (en) | 2012-12-21 | 2019-09-17 | Volcano Corporation | System and method for catheter steering and operation |
US9486143B2 (en) | 2012-12-21 | 2016-11-08 | Volcano Corporation | Intravascular forward imaging device |
US9713666B2 (en) | 2013-01-09 | 2017-07-25 | Medtronic, Inc. | Recirculating dialysate fluid circuit for blood measurement |
US11154648B2 (en) | 2013-01-09 | 2021-10-26 | Medtronic, Inc. | Fluid circuits for sorbent cartridge with sensors |
US9707328B2 (en) | 2013-01-09 | 2017-07-18 | Medtronic, Inc. | Sorbent cartridge to measure solute concentrations |
US11565029B2 (en) | 2013-01-09 | 2023-01-31 | Medtronic, Inc. | Sorbent cartridge with electrodes |
WO2014121162A1 (en) * | 2013-02-01 | 2014-08-07 | Medtronic, Inc. | Sorbent cartridge to measure solute concentrations |
US9623164B2 (en) | 2013-02-01 | 2017-04-18 | Medtronic, Inc. | Systems and methods for multifunctional volumetric fluid control |
US10543052B2 (en) | 2013-02-01 | 2020-01-28 | Medtronic, Inc. | Portable dialysis cabinet |
US10850016B2 (en) | 2013-02-01 | 2020-12-01 | Medtronic, Inc. | Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection |
US10010663B2 (en) | 2013-02-01 | 2018-07-03 | Medtronic, Inc. | Fluid circuit for delivery of renal replacement therapies |
US9526822B2 (en) | 2013-02-01 | 2016-12-27 | Medtronic, Inc. | Sodium and buffer source cartridges for use in a modular controlled compliant flow path |
US9827361B2 (en) | 2013-02-02 | 2017-11-28 | Medtronic, Inc. | pH buffer measurement system for hemodialysis systems |
US9144640B2 (en) | 2013-02-02 | 2015-09-29 | Medtronic, Inc. | Sorbent cartridge configurations for improved dialysate regeneration |
WO2014133974A1 (en) | 2013-02-24 | 2014-09-04 | Pelican Imaging Corporation | Thin form computational and modular array cameras |
WO2014138555A1 (en) | 2013-03-07 | 2014-09-12 | Bernhard Sturm | Multimodal segmentation in intravascular images |
US10226597B2 (en) | 2013-03-07 | 2019-03-12 | Volcano Corporation | Guidewire with centering mechanism |
US20140276923A1 (en) | 2013-03-12 | 2014-09-18 | Volcano Corporation | Vibrating catheter and methods of use |
EP2967391A4 (en) | 2013-03-12 | 2016-11-02 | Donna Collins | SYSTEMS AND METHODS FOR DIAGNOSING CORONARY MICROVASCULAR DISEASE |
US11026591B2 (en) | 2013-03-13 | 2021-06-08 | Philips Image Guided Therapy Corporation | Intravascular pressure sensor calibration |
US9301687B2 (en) | 2013-03-13 | 2016-04-05 | Volcano Corporation | System and method for OCT depth calibration |
JP6339170B2 (ja) | 2013-03-13 | 2018-06-06 | ジンヒョン パーク | 回転式血管内超音波装置から画像を生成するためのシステム及び方法 |
US10292677B2 (en) | 2013-03-14 | 2019-05-21 | Volcano Corporation | Endoluminal filter having enhanced echogenic properties |
US10219887B2 (en) | 2013-03-14 | 2019-03-05 | Volcano Corporation | Filters with echogenic characteristics |
US20160030151A1 (en) | 2013-03-14 | 2016-02-04 | Volcano Corporation | Filters with echogenic characteristics |
GB201305755D0 (en) | 2013-03-28 | 2013-05-15 | Quanta Fluid Solutions Ltd | Re-Use of a Hemodialysis Cartridge |
EP2982397B1 (en) * | 2013-04-01 | 2018-05-23 | Terumo Kabushiki Kaisha | Circulation device and method for controlling same |
EP2799009A1 (en) * | 2013-04-29 | 2014-11-05 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Non-invasive method for prediction of opioid-analgesia and opioid-blood-concentrations |
US20150025449A1 (en) * | 2013-07-22 | 2015-01-22 | Fresenius Medical Care Holdings, Inc. | Activating Peripheral Devices in a Dialysis System |
DE102013108543A1 (de) * | 2013-08-07 | 2015-02-26 | B. Braun Avitum Ag | Vorrichtung und ein Verfahren zur Vorhersage intradialytischer Parameter |
US9898856B2 (en) | 2013-09-27 | 2018-02-20 | Fotonation Cayman Limited | Systems and methods for depth-assisted perspective distortion correction |
ES2856261T3 (es) * | 2013-10-01 | 2021-09-27 | Fresenius Medical Care Deutschland Gmbh | Método y aparatos para determinar una pérdida diaria de hierro de un paciente |
DE102013018284B4 (de) * | 2013-10-31 | 2015-08-27 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zur Erfassung der Hämolyse oder zur Bestimmung eines den Einfluss der Hämolyse auf eine Messung des Hämatokrits korrigierenden Korrekturfaktors |
EP3102107A4 (en) | 2013-11-04 | 2018-02-07 | Medtronic, Inc. | Method and device to manage fluid volumes in the body |
WO2015074078A1 (en) | 2013-11-18 | 2015-05-21 | Pelican Imaging Corporation | Estimating depth from projected texture using camera arrays |
US10537875B2 (en) | 2013-11-26 | 2020-01-21 | Medtronic, Inc. | Precision recharging of sorbent materials using patient and session data |
US9884145B2 (en) | 2013-11-26 | 2018-02-06 | Medtronic, Inc. | Parallel modules for in-line recharging of sorbents using alternate duty cycles |
WO2015081221A1 (en) | 2013-11-27 | 2015-06-04 | Medtronic, Inc. | Precision dialysis monitoring and synchonization system |
EP2918297B1 (de) * | 2014-03-13 | 2016-11-16 | Oertli-Instrumente AG | Kassettenmodul |
MX2016015466A (es) * | 2014-05-29 | 2017-03-23 | Fresenius Medical Care Holdings Inc | Metodo para tratar dializado, sistema de dialisis y metodo para pre-evaluar pacientes de dialisis para el tratamiento con los mismos. |
GB201409796D0 (en) | 2014-06-02 | 2014-07-16 | Quanta Fluid Solutions Ltd | Method of heat sanitization of a haemodialysis water circuit using a calculated dose |
US10357757B2 (en) | 2014-06-24 | 2019-07-23 | Medtronic, Inc. | Stacked sorbent assembly |
WO2015199766A1 (en) | 2014-06-24 | 2015-12-30 | Medtronic, Inc. | Modular dialysate regeneration assembly |
DE102014012024B3 (de) * | 2014-08-13 | 2016-02-04 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung zur Bestimmung des peritonealen Druckes |
JP5839212B1 (ja) * | 2014-08-20 | 2016-01-06 | 泉工医科工業株式会社 | 血液循環システム |
CN104174080B (zh) * | 2014-09-16 | 2016-02-03 | 王卫国 | 一种可独立调整透析液浓度的血液透析机 |
KR101517072B1 (ko) * | 2014-10-08 | 2015-05-04 | 이의호 | 신장의 사구체 여과율 측정 방법 및 장치 |
US11504192B2 (en) | 2014-10-30 | 2022-11-22 | Cilag Gmbh International | Method of hub communication with surgical instrument systems |
US10874787B2 (en) | 2014-12-10 | 2020-12-29 | Medtronic, Inc. | Degassing system for dialysis |
US9895479B2 (en) | 2014-12-10 | 2018-02-20 | Medtronic, Inc. | Water management system for use in dialysis |
US10098993B2 (en) | 2014-12-10 | 2018-10-16 | Medtronic, Inc. | Sensing and storage system for fluid balance |
US9713665B2 (en) | 2014-12-10 | 2017-07-25 | Medtronic, Inc. | Degassing system for dialysis |
CN104437099B (zh) * | 2014-12-19 | 2016-09-07 | 山东中保康医疗器具有限公司 | 一次性使用去白细胞滤器膜材清洗用水的检测方法 |
US10842926B2 (en) | 2015-01-14 | 2020-11-24 | Fresenius Medical Care Deutschland Gmbh | Medical fluid treatment machines and related systems and methods |
SG11201706394QA (en) | 2015-02-12 | 2017-09-28 | Foundry Innovation & Res 1 Ltd | Implantable devices and related methods for heart failure monitoring |
WO2018031714A1 (en) | 2016-08-11 | 2018-02-15 | Foundry Innovation & Research 1, Ltd. | Systems and methods for patient fluid management |
EP3331426A1 (en) | 2015-08-03 | 2018-06-13 | Foundry Innovation&Research 1, Ltd. | Devices and methods for measurement of vena cava dimensions, pressure, and oxygen saturation |
US10335534B2 (en) | 2015-11-06 | 2019-07-02 | Medtronic, Inc. | Dialysis prescription optimization for decreased arrhythmias |
GB2544509B (en) * | 2015-11-19 | 2020-12-09 | Spectrum Medical Ltd | Blood flow rate control apparatus for an extracorporeal perfusion system |
US10406269B2 (en) | 2015-12-29 | 2019-09-10 | Fresenius Medical Care Holdings, Inc. | Electrical sensor for fluids |
US10617809B2 (en) | 2015-12-29 | 2020-04-14 | Fresenius Medical Care Holdings, Inc. | Electrical sensor for fluids |
GB201523104D0 (en) * | 2015-12-30 | 2016-02-10 | Quanta Fluid Solutions Ltd | Dialysis machine |
US10994064B2 (en) | 2016-08-10 | 2021-05-04 | Medtronic, Inc. | Peritoneal dialysate flow path sensing |
US10874790B2 (en) | 2016-08-10 | 2020-12-29 | Medtronic, Inc. | Peritoneal dialysis intracycle osmotic agent adjustment |
CN105999451A (zh) * | 2016-06-17 | 2016-10-12 | 中国人民武装警察部队后勤学院附属医院 | 野战便携式血液净化机 |
US10744253B2 (en) | 2016-08-10 | 2020-08-18 | Medtronic, Inc. | Adaptive peritoneal dialysis intra-session adjustments for overall session optimization |
US10758659B2 (en) * | 2016-08-10 | 2020-09-01 | Medtronic, Inc. | Peritoneal dialysis filtrate sampling and adaptive prescription |
US10537673B2 (en) | 2016-08-10 | 2020-01-21 | Medtronic, Inc. | Intersession adaptive peritoneal dialysis fluid removal for multiple session optimization |
US11206992B2 (en) | 2016-08-11 | 2021-12-28 | Foundry Innovation & Research 1, Ltd. | Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore |
US11701018B2 (en) | 2016-08-11 | 2023-07-18 | Foundry Innovation & Research 1, Ltd. | Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore |
WO2018045102A1 (en) * | 2016-08-30 | 2018-03-08 | Nxstage Medical, Inc. | Parameter monitoring in medical treatment systems |
CN109803694B (zh) * | 2016-09-08 | 2021-09-21 | 爱德芳世株式会社 | 透析治疗中的个体差信息管理系统 |
US11013843B2 (en) | 2016-09-09 | 2021-05-25 | Medtronic, Inc. | Peritoneal dialysis fluid testing system |
JP6716428B2 (ja) * | 2016-11-11 | 2020-07-01 | 日機装株式会社 | 血液浄化治療支援システム |
EP3705031A1 (en) | 2016-11-29 | 2020-09-09 | Foundry Innovation & Research 1, Ltd. | Wireless resonant circuit and variable inductance vascular implants for monitoring patient vasculature system |
US10981148B2 (en) | 2016-11-29 | 2021-04-20 | Medtronic, Inc. | Zirconium oxide module conditioning |
GB201622119D0 (en) | 2016-12-23 | 2017-02-08 | Quanta Dialysis Tech Ltd | Improved valve leak detection system |
WO2018220146A1 (en) | 2017-05-31 | 2018-12-06 | Foundry Innovation & Research 1, Ltd. | Implantable sensors for vascular monitoring |
US11944495B2 (en) | 2017-05-31 | 2024-04-02 | Foundry Innovation & Research 1, Ltd. | Implantable ultrasonic vascular sensor |
US10960381B2 (en) | 2017-06-15 | 2021-03-30 | Medtronic, Inc. | Zirconium phosphate disinfection recharging and conditioning |
US20200155745A1 (en) * | 2017-06-28 | 2020-05-21 | Gambro Lundia Ab | A system and a method for renal replacement therapy |
EP3646336B1 (en) * | 2017-06-28 | 2023-06-28 | Gambro Lundia AB | A system and a method for renal replacement therapy |
US10842924B2 (en) | 2017-06-29 | 2020-11-24 | Fresenius Medical Care Deutschland Gmbh | Therapy control by comprehensive feedback |
CN107273705A (zh) * | 2017-07-25 | 2017-10-20 | 北京品驰医疗设备有限公司 | 人体植入式医疗装置参数确定、设置方法及设备 |
US11510741B2 (en) | 2017-10-30 | 2022-11-29 | Cilag Gmbh International | Method for producing a surgical instrument comprising a smart electrical system |
US11317919B2 (en) | 2017-10-30 | 2022-05-03 | Cilag Gmbh International | Clip applier comprising a clip crimping system |
US11129636B2 (en) | 2017-10-30 | 2021-09-28 | Cilag Gmbh International | Surgical instruments comprising an articulation drive that provides for high articulation angles |
US11406390B2 (en) | 2017-10-30 | 2022-08-09 | Cilag Gmbh International | Clip applier comprising interchangeable clip reloads |
US11229436B2 (en) | 2017-10-30 | 2022-01-25 | Cilag Gmbh International | Surgical system comprising a surgical tool and a surgical hub |
US11291510B2 (en) | 2017-10-30 | 2022-04-05 | Cilag Gmbh International | Method of hub communication with surgical instrument systems |
US11911045B2 (en) | 2017-10-30 | 2024-02-27 | Cllag GmbH International | Method for operating a powered articulating multi-clip applier |
US11564756B2 (en) | 2017-10-30 | 2023-01-31 | Cilag Gmbh International | Method of hub communication with surgical instrument systems |
US11311342B2 (en) | 2017-10-30 | 2022-04-26 | Cilag Gmbh International | Method for communicating with surgical instrument systems |
US11801098B2 (en) | 2017-10-30 | 2023-10-31 | Cilag Gmbh International | Method of hub communication with surgical instrument systems |
US11278654B2 (en) | 2017-12-07 | 2022-03-22 | Medtronic, Inc. | Pneumatic manifold for a dialysis system |
CN107982621B (zh) * | 2017-12-21 | 2023-04-18 | 中国人民解放军总医院 | 吸痰管 |
US11857152B2 (en) | 2017-12-28 | 2024-01-02 | Cilag Gmbh International | Surgical hub spatial awareness to determine devices in operating theater |
US11529187B2 (en) | 2017-12-28 | 2022-12-20 | Cilag Gmbh International | Surgical evacuation sensor arrangements |
US10695081B2 (en) | 2017-12-28 | 2020-06-30 | Ethicon Llc | Controlling a surgical instrument according to sensed closure parameters |
US11432885B2 (en) | 2017-12-28 | 2022-09-06 | Cilag Gmbh International | Sensing arrangements for robot-assisted surgical platforms |
US11234756B2 (en) | 2017-12-28 | 2022-02-01 | Cilag Gmbh International | Powered surgical tool with predefined adjustable control algorithm for controlling end effector parameter |
US11147607B2 (en) | 2017-12-28 | 2021-10-19 | Cilag Gmbh International | Bipolar combination device that automatically adjusts pressure based on energy modality |
US10987178B2 (en) | 2017-12-28 | 2021-04-27 | Ethicon Llc | Surgical hub control arrangements |
US11464559B2 (en) | 2017-12-28 | 2022-10-11 | Cilag Gmbh International | Estimating state of ultrasonic end effector and control system therefor |
US11540855B2 (en) | 2017-12-28 | 2023-01-03 | Cilag Gmbh International | Controlling activation of an ultrasonic surgical instrument according to the presence of tissue |
US11559307B2 (en) | 2017-12-28 | 2023-01-24 | Cilag Gmbh International | Method of robotic hub communication, detection, and control |
US11571234B2 (en) | 2017-12-28 | 2023-02-07 | Cilag Gmbh International | Temperature control of ultrasonic end effector and control system therefor |
US10892995B2 (en) | 2017-12-28 | 2021-01-12 | Ethicon Llc | Surgical network determination of prioritization of communication, interaction, or processing based on system or device needs |
US11576677B2 (en) | 2017-12-28 | 2023-02-14 | Cilag Gmbh International | Method of hub communication, processing, display, and cloud analytics |
US11109866B2 (en) | 2017-12-28 | 2021-09-07 | Cilag Gmbh International | Method for circular stapler control algorithm adjustment based on situational awareness |
US11324557B2 (en) | 2017-12-28 | 2022-05-10 | Cilag Gmbh International | Surgical instrument with a sensing array |
US11179208B2 (en) | 2017-12-28 | 2021-11-23 | Cilag Gmbh International | Cloud-based medical analytics for security and authentication trends and reactive measures |
US11096693B2 (en) | 2017-12-28 | 2021-08-24 | Cilag Gmbh International | Adjustment of staple height of at least one row of staples based on the sensed tissue thickness or force in closing |
US20190201146A1 (en) | 2017-12-28 | 2019-07-04 | Ethicon Llc | Safety systems for smart powered surgical stapling |
US11410259B2 (en) | 2017-12-28 | 2022-08-09 | Cilag Gmbh International | Adaptive control program updates for surgical devices |
US20190201039A1 (en) | 2017-12-28 | 2019-07-04 | Ethicon Llc | Situational awareness of electrosurgical systems |
US11304699B2 (en) | 2017-12-28 | 2022-04-19 | Cilag Gmbh International | Method for adaptive control schemes for surgical network control and interaction |
US11744604B2 (en) | 2017-12-28 | 2023-09-05 | Cilag Gmbh International | Surgical instrument with a hardware-only control circuit |
US11308075B2 (en) | 2017-12-28 | 2022-04-19 | Cilag Gmbh International | Surgical network, instrument, and cloud responses based on validation of received dataset and authentication of its source and integrity |
US11666331B2 (en) | 2017-12-28 | 2023-06-06 | Cilag Gmbh International | Systems for detecting proximity of surgical end effector to cancerous tissue |
US11311306B2 (en) | 2017-12-28 | 2022-04-26 | Cilag Gmbh International | Surgical systems for detecting end effector tissue distribution irregularities |
US11864728B2 (en) | 2017-12-28 | 2024-01-09 | Cilag Gmbh International | Characterization of tissue irregularities through the use of mono-chromatic light refractivity |
US11291495B2 (en) | 2017-12-28 | 2022-04-05 | Cilag Gmbh International | Interruption of energy due to inadvertent capacitive coupling |
US11278281B2 (en) | 2017-12-28 | 2022-03-22 | Cilag Gmbh International | Interactive surgical system |
US11464535B2 (en) | 2017-12-28 | 2022-10-11 | Cilag Gmbh International | Detection of end effector emersion in liquid |
US11364075B2 (en) | 2017-12-28 | 2022-06-21 | Cilag Gmbh International | Radio frequency energy device for delivering combined electrical signals |
US11602393B2 (en) | 2017-12-28 | 2023-03-14 | Cilag Gmbh International | Surgical evacuation sensing and generator control |
US11213359B2 (en) | 2017-12-28 | 2022-01-04 | Cilag Gmbh International | Controllers for robot-assisted surgical platforms |
US10898622B2 (en) | 2017-12-28 | 2021-01-26 | Ethicon Llc | Surgical evacuation system with a communication circuit for communication between a filter and a smoke evacuation device |
US20190201087A1 (en) | 2017-12-28 | 2019-07-04 | Ethicon Llc | Smoke evacuation system including a segmented control circuit for interactive surgical platform |
US11896443B2 (en) | 2017-12-28 | 2024-02-13 | Cilag Gmbh International | Control of a surgical system through a surgical barrier |
US11166772B2 (en) | 2017-12-28 | 2021-11-09 | Cilag Gmbh International | Surgical hub coordination of control and communication of operating room devices |
US11026751B2 (en) | 2017-12-28 | 2021-06-08 | Cilag Gmbh International | Display of alignment of staple cartridge to prior linear staple line |
US11304763B2 (en) | 2017-12-28 | 2022-04-19 | Cilag Gmbh International | Image capturing of the areas outside the abdomen to improve placement and control of a surgical device in use |
US10758310B2 (en) | 2017-12-28 | 2020-09-01 | Ethicon Llc | Wireless pairing of a surgical device with another device within a sterile surgical field based on the usage and situational awareness of devices |
US11317937B2 (en) | 2018-03-08 | 2022-05-03 | Cilag Gmbh International | Determining the state of an ultrasonic end effector |
US10849697B2 (en) | 2017-12-28 | 2020-12-01 | Ethicon Llc | Cloud interface for coupled surgical devices |
US11132462B2 (en) | 2017-12-28 | 2021-09-28 | Cilag Gmbh International | Data stripping method to interrogate patient records and create anonymized record |
US10892899B2 (en) | 2017-12-28 | 2021-01-12 | Ethicon Llc | Self describing data packets generated at an issuing instrument |
US11051876B2 (en) | 2017-12-28 | 2021-07-06 | Cilag Gmbh International | Surgical evacuation flow paths |
US11678881B2 (en) | 2017-12-28 | 2023-06-20 | Cilag Gmbh International | Spatial awareness of surgical hubs in operating rooms |
US11633237B2 (en) | 2017-12-28 | 2023-04-25 | Cilag Gmbh International | Usage and technique analysis of surgeon / staff performance against a baseline to optimize device utilization and performance for both current and future procedures |
US11100631B2 (en) | 2017-12-28 | 2021-08-24 | Cilag Gmbh International | Use of laser light and red-green-blue coloration to determine properties of back scattered light |
US11423007B2 (en) | 2017-12-28 | 2022-08-23 | Cilag Gmbh International | Adjustment of device control programs based on stratified contextual data in addition to the data |
US11257589B2 (en) | 2017-12-28 | 2022-02-22 | Cilag Gmbh International | Real-time analysis of comprehensive cost of all instrumentation used in surgery utilizing data fluidity to track instruments through stocking and in-house processes |
US11253315B2 (en) | 2017-12-28 | 2022-02-22 | Cilag Gmbh International | Increasing radio frequency to create pad-less monopolar loop |
US11844579B2 (en) | 2017-12-28 | 2023-12-19 | Cilag Gmbh International | Adjustments based on airborne particle properties |
US11284936B2 (en) | 2017-12-28 | 2022-03-29 | Cilag Gmbh International | Surgical instrument having a flexible electrode |
US11069012B2 (en) | 2017-12-28 | 2021-07-20 | Cilag Gmbh International | Interactive surgical systems with condition handling of devices and data capabilities |
US11903601B2 (en) | 2017-12-28 | 2024-02-20 | Cilag Gmbh International | Surgical instrument comprising a plurality of drive systems |
US11786251B2 (en) | 2017-12-28 | 2023-10-17 | Cilag Gmbh International | Method for adaptive control schemes for surgical network control and interaction |
US11786245B2 (en) | 2017-12-28 | 2023-10-17 | Cilag Gmbh International | Surgical systems with prioritized data transmission capabilities |
US20190201113A1 (en) | 2017-12-28 | 2019-07-04 | Ethicon Llc | Controls for robot-assisted surgical platforms |
US11446052B2 (en) | 2017-12-28 | 2022-09-20 | Cilag Gmbh International | Variation of radio frequency and ultrasonic power level in cooperation with varying clamp arm pressure to achieve predefined heat flux or power applied to tissue |
US11419667B2 (en) | 2017-12-28 | 2022-08-23 | Cilag Gmbh International | Ultrasonic energy device which varies pressure applied by clamp arm to provide threshold control pressure at a cut progression location |
US11419630B2 (en) | 2017-12-28 | 2022-08-23 | Cilag Gmbh International | Surgical system distributed processing |
US11389164B2 (en) | 2017-12-28 | 2022-07-19 | Cilag Gmbh International | Method of using reinforced flexible circuits with multiple sensors to optimize performance of radio frequency devices |
US20190200981A1 (en) | 2017-12-28 | 2019-07-04 | Ethicon Llc | Method of compressing tissue within a stapling device and simultaneously displaying the location of the tissue within the jaws |
US11937769B2 (en) | 2017-12-28 | 2024-03-26 | Cilag Gmbh International | Method of hub communication, processing, storage and display |
US11896322B2 (en) | 2017-12-28 | 2024-02-13 | Cilag Gmbh International | Sensing the patient position and contact utilizing the mono-polar return pad electrode to provide situational awareness to the hub |
US10932872B2 (en) | 2017-12-28 | 2021-03-02 | Ethicon Llc | Cloud-based medical analytics for linking of local usage trends with the resource acquisition behaviors of larger data set |
US11273001B2 (en) | 2017-12-28 | 2022-03-15 | Cilag Gmbh International | Surgical hub and modular device response adjustment based on situational awareness |
US11304720B2 (en) | 2017-12-28 | 2022-04-19 | Cilag Gmbh International | Activation of energy devices |
US11202570B2 (en) | 2017-12-28 | 2021-12-21 | Cilag Gmbh International | Communication hub and storage device for storing parameters and status of a surgical device to be shared with cloud based analytics systems |
US11832899B2 (en) | 2017-12-28 | 2023-12-05 | Cilag Gmbh International | Surgical systems with autonomously adjustable control programs |
US11376002B2 (en) | 2017-12-28 | 2022-07-05 | Cilag Gmbh International | Surgical instrument cartridge sensor assemblies |
US11559308B2 (en) | 2017-12-28 | 2023-01-24 | Cilag Gmbh International | Method for smart energy device infrastructure |
US11076921B2 (en) | 2017-12-28 | 2021-08-03 | Cilag Gmbh International | Adaptive control program updates for surgical hubs |
US10966791B2 (en) | 2017-12-28 | 2021-04-06 | Ethicon Llc | Cloud-based medical analytics for medical facility segmented individualization of instrument function |
US10944728B2 (en) | 2017-12-28 | 2021-03-09 | Ethicon Llc | Interactive surgical systems with encrypted communication capabilities |
US11589888B2 (en) | 2017-12-28 | 2023-02-28 | Cilag Gmbh International | Method for controlling smart energy devices |
US11659023B2 (en) | 2017-12-28 | 2023-05-23 | Cilag Gmbh International | Method of hub communication |
US11818052B2 (en) | 2017-12-28 | 2023-11-14 | Cilag Gmbh International | Surgical network determination of prioritization of communication, interaction, or processing based on system or device needs |
US11424027B2 (en) | 2017-12-28 | 2022-08-23 | Cilag Gmbh International | Method for operating surgical instrument systems |
US11056244B2 (en) | 2017-12-28 | 2021-07-06 | Cilag Gmbh International | Automated data scaling, alignment, and organizing based on predefined parameters within surgical networks |
US10943454B2 (en) | 2017-12-28 | 2021-03-09 | Ethicon Llc | Detection and escalation of security responses of surgical instruments to increasing severity threats |
US11832840B2 (en) | 2017-12-28 | 2023-12-05 | Cilag Gmbh International | Surgical instrument having a flexible circuit |
US11266468B2 (en) | 2017-12-28 | 2022-03-08 | Cilag Gmbh International | Cooperative utilization of data derived from secondary sources by intelligent surgical hubs |
US20190201042A1 (en) | 2017-12-28 | 2019-07-04 | Ethicon Llc | Determining the state of an ultrasonic electromechanical system according to frequency shift |
US11160605B2 (en) | 2017-12-28 | 2021-11-02 | Cilag Gmbh International | Surgical evacuation sensing and motor control |
US11304745B2 (en) * | 2017-12-28 | 2022-04-19 | Cilag Gmbh International | Surgical evacuation sensing and display |
US10881347B2 (en) | 2017-12-29 | 2021-01-05 | Fresenius Medical Care Holdings, Inc. | Closed loop dialysis treatment using adaptive ultrafiltration rates |
CN111801124B (zh) * | 2018-01-10 | 2023-05-23 | 尼普洛株式会社 | 细胞外液量计算装置和细胞外液量计算方法 |
US11033667B2 (en) | 2018-02-02 | 2021-06-15 | Medtronic, Inc. | Sorbent manifold for a dialysis system |
US11110215B2 (en) | 2018-02-23 | 2021-09-07 | Medtronic, Inc. | Degasser and vent manifolds for dialysis |
US11839396B2 (en) | 2018-03-08 | 2023-12-12 | Cilag Gmbh International | Fine dissection mode for tissue classification |
US11701162B2 (en) | 2018-03-08 | 2023-07-18 | Cilag Gmbh International | Smart blade application for reusable and disposable devices |
US11259830B2 (en) | 2018-03-08 | 2022-03-01 | Cilag Gmbh International | Methods for controlling temperature in ultrasonic device |
US11129611B2 (en) | 2018-03-28 | 2021-09-28 | Cilag Gmbh International | Surgical staplers with arrangements for maintaining a firing member thereof in a locked configuration unless a compatible cartridge has been installed therein |
US11589865B2 (en) | 2018-03-28 | 2023-02-28 | Cilag Gmbh International | Methods for controlling a powered surgical stapler that has separate rotary closure and firing systems |
US10973520B2 (en) | 2018-03-28 | 2021-04-13 | Ethicon Llc | Surgical staple cartridge with firing member driven camming assembly that has an onboard tissue cutting feature |
US11207067B2 (en) | 2018-03-28 | 2021-12-28 | Cilag Gmbh International | Surgical stapling device with separate rotary driven closure and firing systems and firing member that engages both jaws while firing |
US11096688B2 (en) | 2018-03-28 | 2021-08-24 | Cilag Gmbh International | Rotary driven firing members with different anvil and channel engagement features |
US11471156B2 (en) | 2018-03-28 | 2022-10-18 | Cilag Gmbh International | Surgical stapling devices with improved rotary driven closure systems |
US11090047B2 (en) | 2018-03-28 | 2021-08-17 | Cilag Gmbh International | Surgical instrument comprising an adaptive control system |
US11219453B2 (en) | 2018-03-28 | 2022-01-11 | Cilag Gmbh International | Surgical stapling devices with cartridge compatible closure and firing lockout arrangements |
US11278280B2 (en) | 2018-03-28 | 2022-03-22 | Cilag Gmbh International | Surgical instrument comprising a jaw closure lockout |
JP7153612B2 (ja) | 2018-06-29 | 2022-10-14 | 株式会社アドバンス | 血液透析用の経皮端子 |
ES2941533T3 (es) | 2018-07-26 | 2023-05-23 | Baxter Int | Sistema de diálisis peritoneal con sensores y configurado para diagnosticar peritonitis |
EP3793635B1 (en) | 2018-07-27 | 2023-12-27 | Fresenius Medical Care Holdings, Inc. | System and method for tailoring dialysis treatment |
US11213616B2 (en) | 2018-08-24 | 2022-01-04 | Medtronic, Inc. | Recharge solution for zirconium phosphate |
EP3860460A4 (en) * | 2018-10-05 | 2022-07-20 | Pharmacophotonics, Inc. D/B/A Fast Biomedical | METHOD AND DEVICE FOR DETERMINING INTERSTITIAL VOLUME |
US11806457B2 (en) | 2018-11-16 | 2023-11-07 | Mozarc Medical Us Llc | Peritoneal dialysis adequacy meaurements |
JP7183006B2 (ja) * | 2018-11-22 | 2022-12-05 | 旭化成メディカル株式会社 | 体液分離システム及び体液分離システムの作動方法 |
US11806456B2 (en) | 2018-12-10 | 2023-11-07 | Mozarc Medical Us Llc | Precision peritoneal dialysis therapy based on dialysis adequacy measurements |
CN109394200B (zh) * | 2018-12-16 | 2021-10-19 | 冯兴怀 | 用于液体治疗、容量管理的微循环脉冲血流监测系统和方法 |
US11317915B2 (en) | 2019-02-19 | 2022-05-03 | Cilag Gmbh International | Universal cartridge based key feature that unlocks multiple lockout arrangements in different surgical staplers |
US11751872B2 (en) | 2019-02-19 | 2023-09-12 | Cilag Gmbh International | Insertable deactivator element for surgical stapler lockouts |
US11259807B2 (en) | 2019-02-19 | 2022-03-01 | Cilag Gmbh International | Staple cartridges with cam surfaces configured to engage primary and secondary portions of a lockout of a surgical stapling device |
US11357503B2 (en) | 2019-02-19 | 2022-06-14 | Cilag Gmbh International | Staple cartridge retainers with frangible retention features and methods of using same |
US11369377B2 (en) | 2019-02-19 | 2022-06-28 | Cilag Gmbh International | Surgical stapling assembly with cartridge based retainer configured to unlock a firing lockout |
CN110124138B (zh) * | 2019-04-19 | 2022-05-10 | 暨南大学 | 一种血液透析过程中干体重控制系统 |
CN110152087A (zh) * | 2019-04-19 | 2019-08-23 | 暨南大学 | 一种血液透析过程的监测方法 |
US11160503B2 (en) * | 2019-04-23 | 2021-11-02 | Fresenius Medical Care Holdings, Inc. | Wearable continuous vascular access monitor |
US11684503B2 (en) * | 2019-05-15 | 2023-06-27 | Syn LLC | Gastric reduction apparatus and related methods |
US10926019B2 (en) | 2019-06-05 | 2021-02-23 | Choon Kee Lee | Gradient dialysate hemodiafiltration |
USD952144S1 (en) | 2019-06-25 | 2022-05-17 | Cilag Gmbh International | Surgical staple cartridge retainer with firing system authentication key |
USD950728S1 (en) | 2019-06-25 | 2022-05-03 | Cilag Gmbh International | Surgical staple cartridge |
USD964564S1 (en) | 2019-06-25 | 2022-09-20 | Cilag Gmbh International | Surgical staple cartridge retainer with a closure system authentication key |
US11510614B1 (en) | 2019-12-02 | 2022-11-29 | Express Scripts Strategic Development, Inc. | Wearable devices and systems for prescription adherence |
EP3834860A1 (fr) * | 2019-12-11 | 2021-06-16 | Infomed SA | Dispositif de circulation extracorporelle du sang |
EP4129356A4 (en) * | 2020-03-31 | 2023-08-23 | Asahi Kasei Medical Co., Ltd. | BLOOD PURIFICATION SYSTEM, CONTROL METHOD, CONTROL PROGRAM, LEARNING DEVICE AND LEARNING METHOD |
CN115348877A (zh) * | 2020-03-31 | 2022-11-15 | 旭化成医疗株式会社 | 血液净化系统、控制方法、控制程序、学习装置以及学习方法 |
US20220047793A1 (en) * | 2020-08-12 | 2022-02-17 | Medtronic, Inc. | Dialysis catheter including pressure and impedance sensors |
DE102020128298A1 (de) | 2020-10-28 | 2022-04-28 | Fresenius Medical Care Deutschland Gmbh | Patientenmonitorsystem zum Erfassen von Daten eines Patienten, Anzeigevorrichtung, medizinische Behandlungsvorrichtung und Verfahren |
EP4085940A1 (en) * | 2021-05-07 | 2022-11-09 | Imec VZW | A method and a maintenance device for automatic maintenance of an autonomous dialysis system |
WO2022240488A1 (en) * | 2021-05-14 | 2022-11-17 | Fresenius Medical Care Holdings, Inc. | Extracorporeal device and method for removal of secondary membrane |
US20220392621A1 (en) * | 2021-06-08 | 2022-12-08 | Medtronic, Inc. | Artificially intelligent smart home assistant for home-based medical therapy |
US11850344B2 (en) | 2021-08-11 | 2023-12-26 | Mozarc Medical Us Llc | Gas bubble sensor |
US11944733B2 (en) | 2021-11-18 | 2024-04-02 | Mozarc Medical Us Llc | Sodium and bicarbonate control |
WO2023107591A1 (en) * | 2021-12-08 | 2023-06-15 | Orrum Clinical Analytics, Inc. | Blood volume sensor system |
CN115998253B (zh) * | 2022-12-22 | 2023-08-04 | 北大荒集团总医院 | 一种腹腔积液变化情况监测方法及监测装置 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101193667A (zh) * | 2005-04-08 | 2008-06-04 | 日机装株式会社 | 血液透析装置和血液透析方法 |
Family Cites Families (404)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2002A (en) | 1841-03-12 | Tor and planter for plowing | ||
US1383728A (en) | 1921-07-05 | new yobk | ||
GB1189458A (en) | 1967-09-27 | 1970-04-29 | Nat Res Dev | Improvements in or relating to dialysers |
US3602222A (en) | 1968-09-16 | 1971-08-31 | Honeywell Inc | Rate meter, particularly a beat-by-beat cardiotachometer |
US3669878A (en) | 1968-12-02 | 1972-06-13 | Health Education And Welfare U | Treatment of dialysate solution for removal of urea |
GB1280521A (en) | 1969-06-28 | 1972-07-05 | Whitely Lang And Neill Ltd | Peritoneal dialysis apparatus |
US3669880A (en) | 1969-06-30 | 1972-06-13 | Cci Aerospace Corp | Recirculation dialysate system for use with an artificial kidney machine |
US3754867A (en) | 1970-12-11 | 1973-08-28 | Bjorksten Res Lab Inc | Carbon dioxide sensing system |
DE2239254C2 (de) | 1970-12-30 | 1983-08-04 | Organon Teknika Corp., Oklahoma City, Okla. | "Säule zur Regenerierung einer zirkulierenden Dialysatlösung und Verwendung dieser Säule". |
US3850835A (en) | 1971-11-08 | 1974-11-26 | Cci Life Systems Inc | Method of making granular zirconium hydrous oxide ion exchangers, such as zirconium phosphate and hydrous zirconium oxide, particularly for column use |
US3884808A (en) | 1973-06-20 | 1975-05-20 | Res Dev Systems Inc | Wearable, self-regenerating dialysis appliance |
US3930181A (en) | 1973-12-28 | 1975-12-30 | Ibm | Lens and deflection unit arrangement for electron beam columns |
US3990973A (en) | 1974-11-04 | 1976-11-09 | Cobe Laboratories, Inc. | Apparatus for measuring ultrafiltration rate |
US3989625A (en) | 1975-02-25 | 1976-11-02 | Ma-De Inc. | Detector for air in blood dialysis systems |
US4060485A (en) | 1975-06-09 | 1977-11-29 | I T L Technology, Inc. | Dialysis apparatus |
US4581141A (en) | 1978-02-27 | 1986-04-08 | Purdue Research Foundation | Dialysis material and method for removing uremic substances |
JPS55138462A (en) * | 1979-04-18 | 1980-10-29 | Mediks Kk | Living body installing type hydrogen ion concentration asjusting device |
US4556063A (en) | 1980-10-07 | 1985-12-03 | Medtronic, Inc. | Telemetry system for a medical device |
US4374382A (en) | 1981-01-16 | 1983-02-15 | Medtronic, Inc. | Marker channel telemetry system for a medical device |
US4371385A (en) | 1981-04-28 | 1983-02-01 | Cobe Laboratories, Inc. | Deaerating liquid |
US4381999A (en) | 1981-04-28 | 1983-05-03 | Cobe Laboratories, Inc. | Automatic ultrafiltration control system |
US4750494A (en) | 1981-05-12 | 1988-06-14 | Medtronic, Inc. | Automatic implantable fibrillation preventer |
JPS58155864A (ja) * | 1982-03-10 | 1983-09-16 | 株式会社豊田中央研究所 | 血液浄化装置 |
DE3377897D1 (en) | 1982-06-21 | 1988-10-13 | Fresenius Ag | Dialysis device with controlled composition of dialysis solution |
DE3224823A1 (de) | 1982-07-02 | 1984-01-05 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung einer fuer den entsprechenden krankheitsfall optimierten elektrolytloesung zur anwendung in der haemodialyse |
US4460555A (en) | 1983-08-25 | 1984-07-17 | Organon Teknika Corporation | Ammonia scavenger |
US4650587A (en) | 1982-09-09 | 1987-03-17 | Akzona Incorporated | Ammonia scavenger |
US4678408A (en) | 1984-01-06 | 1987-07-07 | Pacesetter Infusion, Ltd. | Solenoid drive apparatus for an external infusion pump |
US4685903A (en) | 1984-01-06 | 1987-08-11 | Pacesetter Infusion, Ltd. | External infusion pump apparatus |
US4562751A (en) | 1984-01-06 | 1986-01-07 | Nason Clyde K | Solenoid drive apparatus for an external infusion pump |
US4718891A (en) * | 1984-05-03 | 1988-01-12 | Henry Ford Hospital | Automated hemodialysis control based upon patient blood pressure and heart rate |
US5643201A (en) | 1984-07-09 | 1997-07-01 | Peabody; Alan M. | Continuous peritoneal dialysis apparatus |
US4747822A (en) | 1984-07-09 | 1988-05-31 | Peabody Alan M | Continuous flow peritoneal dialysis system and method |
US4661246A (en) | 1984-10-01 | 1987-04-28 | Ash Medical Systems, Inc. | Dialysis instrument with dialysate side pump for moving body fluids |
JPS61119276A (ja) | 1984-11-14 | 1986-06-06 | 株式会社 ニツシヨ− | 限外濾過量制御装置 |
IT1191613B (it) | 1985-05-15 | 1988-03-23 | Eniricerche Spa | Fosfato di zirconio e suo metodo di preparazione |
US5091094A (en) * | 1985-06-24 | 1992-02-25 | Veech Richard L | Hemodialysis processes & hemodialysis solutions |
US4772560A (en) | 1985-11-18 | 1988-09-20 | Attar Amir J | Laminated wafer for sensing and monitoring exposure to gases |
US4976683A (en) | 1986-06-20 | 1990-12-11 | Abbott Laboratories | Peritoneal dialysis method |
DE3785147T2 (de) | 1986-11-07 | 1996-09-19 | Asahi Chemical Ind | Membran aus regenerierter Zellulose und Verfahren zu ihrer Herstellung. |
DE3640089A1 (de) * | 1986-11-24 | 1988-06-01 | Fresenius Ag | Verfahren und vorrichtung zur bestimmung des intravasalen blutvolumens waehrend der haemodialyse |
US4799493A (en) | 1987-03-13 | 1989-01-24 | Cardiac Pacemakers, Inc. | Dual channel coherent fibrillation detection system |
US4828693A (en) | 1987-09-22 | 1989-05-09 | Baxter Travenol Laboratories, Inc. | Water pressure regulator for hemodialysis apparatus |
GB8722854D0 (en) | 1987-09-29 | 1987-11-04 | Hardy S M | Implantable artificial kidney |
SE465404B (sv) * | 1988-03-03 | 1991-09-09 | Gambro Ab | Dialyssystem |
CA1327838C (fr) | 1988-06-13 | 1994-03-15 | Fred Zacouto | Dispositif implantable de protection contre les affections liees a la coagulation sanguine |
US5092838A (en) | 1989-11-30 | 1992-03-03 | Baxter International Inc. | Histidine buffered peritoneal dialysis solution |
EP0402505B1 (en) | 1989-06-15 | 1993-12-15 | Alan M. Peabody | Continuous cyclic peritoneal dialysis system |
US5127404A (en) | 1990-01-22 | 1992-07-07 | Medtronic, Inc. | Telemetry format for implanted medical device |
US5141493A (en) | 1990-01-26 | 1992-08-25 | Sarcos Group | Peritoneal dialysis system |
FR2660866B1 (fr) * | 1990-04-13 | 1992-06-12 | Hogamed | Procede et dispositif de preparation d'un liquide de substitution. |
US5097122A (en) | 1990-04-16 | 1992-03-17 | Pacesetter Infusion, Ltd. | Medication infusion system having optical motion sensor to detect drive mechanism malfunction |
US5080653A (en) | 1990-04-16 | 1992-01-14 | Pacesetter Infusion, Ltd. | Infusion pump with dual position syringe locator |
US5091642A (en) | 1990-05-11 | 1992-02-25 | Mda Scientific, Inc. | Colorimetric detection apparatus |
US5032265A (en) | 1990-06-20 | 1991-07-16 | Millipore Corporation | Method and system for producing sterile aqueous solutions |
FR2680976B1 (fr) | 1991-09-10 | 1998-12-31 | Hospal Ind | Rein artificiel muni de moyens de determination caracteristiques du sang et procede de determination correspondant. |
FR2680975B1 (fr) * | 1991-09-10 | 1998-12-31 | Hospal Ind | Rein artificiel muni de moyens pour doser une substance dans le sang. |
JPH0599464A (ja) | 1991-10-08 | 1993-04-20 | Nec Corp | エアシヤワー装置 |
FR2687307B1 (fr) | 1992-02-14 | 1999-06-04 | Lascombes Jean Jacques | Dispositif pour la preparation d'une solution a usage medical. |
US5284470A (en) | 1992-11-02 | 1994-02-08 | Beltz Alex D | Wearable, portable, light-weight artificial kidney |
DE4303860C2 (de) | 1993-02-10 | 1995-11-09 | Draegerwerk Ag | Träger für den kolorimetrischen Gasnachweis in Folienverbundbauweise |
US5302288A (en) | 1993-03-19 | 1994-04-12 | Zimpro Environmental, Inc. | Treatment of highly colored wastewaters |
JPH06327767A (ja) * | 1993-05-10 | 1994-11-29 | Shinton Chem Ind Corp Ltd | 即時適切に透析を行う装置及び方法 |
DE4321927C2 (de) | 1993-07-01 | 1998-07-09 | Sartorius Gmbh | Filtereinheit mit Entgasungsvorrichtung |
US5364593A (en) | 1993-07-26 | 1994-11-15 | Mihaylov Gueorgui M | Direct-read colorimetric exposimeter |
US5308315A (en) | 1993-07-27 | 1994-05-03 | Raja N. Khuri | Method for determining the adequacy of dialysis |
US5507723A (en) * | 1994-05-24 | 1996-04-16 | Baxter International, Inc. | Method and system for optimizing dialysis clearance |
FR2723002B1 (fr) * | 1994-07-26 | 1996-09-06 | Hospal Ind | Dispositif et procede pour preparer un liquide de traitement par filtration |
US5591344A (en) | 1995-02-13 | 1997-01-07 | Aksys, Ltd. | Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof |
US5944684A (en) | 1995-08-31 | 1999-08-31 | The Regents Of The University Of California | Wearable peritoneum-based system for continuous renal function replacement and other biomedical applications |
US6363279B1 (en) | 1996-01-08 | 2002-03-26 | Impulse Dynamics N.V. | Electrical muscle controller |
US5683432A (en) | 1996-01-11 | 1997-11-04 | Medtronic, Inc. | Adaptive, performance-optimizing communication system for communicating with an implanted medical device |
US5819007A (en) | 1996-03-15 | 1998-10-06 | Siemens Medical Systems, Inc. | Feature-based expert system classifier |
JPH09327511A (ja) * | 1996-06-12 | 1997-12-22 | A S A Sangyo Kk | 腹膜透析液の回収・再生方法並びにそのための処理装置及び付属器具 |
EP0944414B1 (en) | 1996-07-11 | 2005-11-09 | Medtronic, Inc. | Minimally invasive implantable device for monitoring physiologic events |
US5902336A (en) * | 1996-10-15 | 1999-05-11 | Mirimedical, Inc. | Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure |
US6048732A (en) | 1996-10-16 | 2000-04-11 | Board Of Regents, The University Of Texas System | Receptor and method for citrate determination |
AU7722398A (en) | 1997-05-29 | 1998-12-30 | Joseph P. D'angelo | Estimation of active infection by helicobacter pylori |
US6042721A (en) | 1997-07-23 | 2000-03-28 | Fabco Industries, Inc. | Effluent treatment apparatus |
CA2211848C (en) | 1997-07-28 | 2002-06-11 | Joseph E. Dadson | Peritoneal dialysis apparatus |
SE9703600D0 (sv) | 1997-10-02 | 1997-10-02 | Pacesetter Ab | Heart stimulator |
US6088608A (en) | 1997-10-20 | 2000-07-11 | Alfred E. Mann Foundation | Electrochemical sensor and integrity tests therefor |
DE19747360B8 (de) | 1997-10-27 | 2007-05-16 | Fresenius Medical Care De Gmbh | Verfahren zur Messung von Leistungsparametern von Stoff- und Energieaustausch Modulen |
SE9703958D0 (sv) | 1997-10-29 | 1997-10-29 | Pacesetter Ab | Method and device for determination of concentration |
US6648845B1 (en) | 1998-01-07 | 2003-11-18 | Fresenius Medical Care North America | Method and apparatus for determining hemodialysis parameters |
SE520638C2 (sv) | 1998-01-21 | 2003-08-05 | Gambro Lundia Ab | Säkerhetsanordning vid dialysmaskin |
SE9800407D0 (sv) | 1998-02-12 | 1998-02-12 | Pacesetter Ab | Heart stimulator |
US6074315A (en) | 1998-02-19 | 2000-06-13 | Linda C. Yimoyines | Racquet with visually differentiated grommets and method of stringing thereof |
US6197197B1 (en) | 1998-04-23 | 2001-03-06 | Dialysis Systems, Inc. | Method for fluid delivery in a dialysis clinic |
US6058331A (en) | 1998-04-27 | 2000-05-02 | Medtronic, Inc. | Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control |
US6561996B1 (en) * | 1998-05-19 | 2003-05-13 | Transvivo, Inc. | Apparatus and method for in vivo hemodialysis |
DE19823570A1 (de) | 1998-05-27 | 1999-12-02 | Kfh Kuratorium Fuer Dialyse Un | Verfahren und Vorrichtung zum Austausch von Flüssigkeiten und/oder gelöster Substanzen insbesondere bei einer Dialysebehandlung |
US6554798B1 (en) | 1998-08-18 | 2003-04-29 | Medtronic Minimed, Inc. | External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities |
US7670491B2 (en) | 1998-10-20 | 2010-03-02 | Advanced Renal Technologies | Buffered compositions for dialysis |
US6726647B1 (en) | 1998-10-23 | 2004-04-27 | Gambro Ab | Method and device for measuring access flow |
EP1124599B1 (en) | 1998-10-23 | 2013-07-24 | Gambro Lundia AB | Device for measuring access flow by dialysis |
CA2533850C (en) | 1998-10-29 | 2009-09-01 | Medtronic Minimed, Inc. | Reservoir connector |
US6248093B1 (en) | 1998-10-29 | 2001-06-19 | Minimed Inc. | Compact pump drive system |
US7077819B1 (en) | 1998-12-24 | 2006-07-18 | Fresenius Medical Care Deutschland Gmbh | Method for determining the distribution volume of a blood component during an extracorporeal blood treatment and device for carrying out the method |
US6254567B1 (en) | 1999-02-26 | 2001-07-03 | Nxstage Medical, Inc. | Flow-through peritoneal dialysis systems and methods with on-line dialysis solution regeneration |
US6274103B1 (en) | 1999-03-26 | 2001-08-14 | Prismedical Corporation | Apparatus and method for preparation of a peritoneal dialysis solution |
US6230059B1 (en) | 1999-03-17 | 2001-05-08 | Medtronic, Inc. | Implantable monitor |
SE9901165D0 (sv) | 1999-03-30 | 1999-03-30 | Gambro Lundia Ab | Method, apparatus and components of dialysis systems |
US6780322B1 (en) | 1999-04-30 | 2004-08-24 | Children's Hospital Medical Center | Hemofiltration system |
US6669663B1 (en) * | 1999-04-30 | 2003-12-30 | Medtronic, Inc. | Closed loop medicament pump |
US6505075B1 (en) | 1999-05-29 | 2003-01-07 | Richard L. Weiner | Peripheral nerve stimulation method |
IT1310659B1 (it) * | 1999-07-30 | 2002-02-19 | Hospal Dasco Spa | Metodo di controllo di una macchina per dialisi avente un filtrosemipermeabile. |
DE19938691A1 (de) | 1999-08-14 | 2001-02-15 | Volkswagen Ag | Verfahren zur verkehrsgeführten Beeinflussung und/oder Unterstützung von Kraftfahrzeugen |
US6272377B1 (en) | 1999-10-01 | 2001-08-07 | Cardiac Pacemakers, Inc. | Cardiac rhythm management system with arrhythmia prediction and prevention |
FR2799727B1 (fr) | 1999-10-19 | 2001-11-23 | Entpr De Mecanique Et D Outil | Dispositif de repartition des comprimes ou equivalents pour installation de conditionnement dans des feuilles alveolees en deplacement |
IT1308861B1 (it) | 1999-11-02 | 2002-01-11 | Gambro Dasco Spa | Metodo di controllo di una apparecchiatura di dialisi dedicataall'implementazione della tecnica dialitica afbk e relativa |
DE19955578C1 (de) | 1999-11-18 | 2001-09-06 | Fresenius Medical Care De Gmbh | Mehrkammerbehälter, mit Glucosekonzentratkompartiment und Salzsäurekonzentratkompartiment |
FR2804265B1 (fr) | 2000-01-25 | 2003-06-27 | Centre Nat Rech Scient | Systeme pour le suivi a distance de patients |
US6602399B1 (en) | 2000-03-22 | 2003-08-05 | Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften E.V. | Signal recording of a receptor-effector-system by an extracellular planar potential-sensitive electrode |
US20010041869A1 (en) | 2000-03-23 | 2001-11-15 | Causey James D. | Control tabs for infusion devices and methods of using the same |
IL136079A0 (en) | 2000-04-19 | 2001-05-20 | Cheetah Medical Inc C O Pepper | Method and apparatus for monitoring the cardiovascular condition, particularly the degree of arteriosclerosis in individuals |
AU2001259469A1 (en) | 2000-05-05 | 2001-11-20 | Hemocleanse, Inc. | Use of magnetic particles or other particles having relatively high density in afluid for mixing and/or leak detection |
US6887214B1 (en) | 2000-09-12 | 2005-05-03 | Chf Solutions, Inc. | Blood pump having a disposable blood passage cartridge with integrated pressure sensors |
US6890315B1 (en) | 2000-05-23 | 2005-05-10 | Chf Solutions, Inc. | Method and apparatus for vein fluid removal in heart failure |
US20010048637A1 (en) | 2000-05-24 | 2001-12-06 | Weigl Bernhard H. | Microfluidic system and method |
WO2001095955A1 (fr) * | 2000-06-15 | 2001-12-20 | Jms Co., Ltd. | Dialyseur automatique et procede de dialyse |
US6589229B1 (en) | 2000-07-31 | 2003-07-08 | Becton, Dickinson And Company | Wearable, self-contained drug infusion device |
US6615077B1 (en) | 2000-08-14 | 2003-09-02 | Renal Research Institute, Llc | Device and method for monitoring and controlling physiologic parameters of a dialysis patient using segmental bioimpedence |
US6689083B1 (en) | 2000-11-27 | 2004-02-10 | Chf Solutions, Inc. | Controller for ultrafiltration blood circuit which prevents hypotension by monitoring osmotic pressure in blood |
US7033498B2 (en) | 2000-11-28 | 2006-04-25 | Renal Solutions, Inc. | Cartridges useful in cleaning dialysis solutions |
US6627164B1 (en) | 2000-11-28 | 2003-09-30 | Renal Solutions, Inc. | Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same |
PT1347823E (pt) | 2000-12-12 | 2006-07-31 | Jurag Separation As | Metodo e equipamento para o isolamento de especies ionicas a partir de um liquido |
ES2432351T3 (es) | 2000-12-20 | 2013-12-02 | Nephros, Inc. | Aparato de hemodiafiltración/hemofiltración de varias etapas |
DE10114283C2 (de) | 2000-12-22 | 2003-04-24 | Fresenius Medical Care De Gmbh | Verfahren zur Ermittlung der Ionenkonzentration des Blutes eines Patienten bei der citrat-antikoagulierten Hämodialyse und/oder Hämofiltration; Dialysegerät |
WO2002053209A1 (en) * | 2000-12-27 | 2002-07-11 | Philips Japan, Ltd. | Biological information and blood treating device information control system, biological information and blood treating device information control device, and biological information and blood treating device information control method |
US6706007B2 (en) | 2000-12-29 | 2004-03-16 | Chf Solutions, Inc. | Feedback control of ultrafiltration to prevent hypotension |
SE523860C2 (sv) | 2001-01-08 | 2004-05-25 | Gambro Lundia Ab | Kopplingsanordning och medicinsk ledningsuppsättning med sådan kopplingsanordning |
JP2003010319A (ja) * | 2001-07-03 | 2003-01-14 | Nippon Colin Co Ltd | 透析装置 |
US6544212B2 (en) | 2001-07-31 | 2003-04-08 | Roche Diagnostics Corporation | Diabetes management system |
US6960179B2 (en) | 2001-11-16 | 2005-11-01 | National Quality Care, Inc | Wearable continuous renal replacement therapy device |
SE525132C2 (sv) | 2001-11-23 | 2004-12-07 | Gambro Lundia Ab | Metod vid manövrering av dialysanordning |
US6878283B2 (en) | 2001-11-28 | 2005-04-12 | Renal Solutions, Inc. | Filter cartridge assemblies and methods for filtering fluids |
US20030114787A1 (en) | 2001-12-13 | 2003-06-19 | Victor Gura | Wearable peritoneal dialysis system |
US20030113931A1 (en) | 2001-12-14 | 2003-06-19 | Li Pan | Ammonia and ammonium sensors |
DE10204963A1 (de) | 2002-02-06 | 2003-08-14 | Isco Inc | Fotometrische Sonde für Untersuchungen an Flüssigkeiten sowie Verfahren hierfür |
US6711439B1 (en) | 2002-02-14 | 2004-03-23 | Pacesetter, Inc. | Evoked response variability as an indicator of autonomic tone and surrogate for patient condition |
US7076299B2 (en) | 2002-03-28 | 2006-07-11 | Tran Thong | Method and apparatus for preventing heart tachyarrhythmia |
US20030199951A1 (en) | 2002-04-22 | 2003-10-23 | Pardo Xavier E. | Implantable lead with improved conductor lumens |
US7207946B2 (en) | 2002-05-09 | 2007-04-24 | Spiration, Inc. | Automated provision of information related to air evacuation from a chest cavity |
US20030216677A1 (en) * | 2002-05-15 | 2003-11-20 | Li Pan | Biosensor for dialysis therapy |
US7153286B2 (en) | 2002-05-24 | 2006-12-26 | Baxter International Inc. | Automated dialysis system |
US20040001931A1 (en) * | 2002-06-25 | 2004-01-01 | 3M Innovative Properties Company | Linerless printable adhesive tape |
JP4129866B2 (ja) * | 2002-07-18 | 2008-08-06 | 日機装株式会社 | 血液処理装置 |
JP2004049492A (ja) * | 2002-07-18 | 2004-02-19 | Jms Co Ltd | 基準体重算出方法および血液透析装置 |
EP2168612A3 (en) | 2002-07-19 | 2010-07-21 | Baxter International Inc. | Systems and methods for peritoneal dialysis |
WO2004009158A2 (en) | 2002-07-19 | 2004-01-29 | Baxter International Inc. | Systems and methods for performing peritoneal dialysis |
US7238164B2 (en) | 2002-07-19 | 2007-07-03 | Baxter International Inc. | Systems, methods and apparatuses for pumping cassette-based therapies |
EP1523347B1 (en) | 2002-07-19 | 2011-05-18 | Baxter International Inc. | Systems and methods for performing peritoneal dialysis |
US6609023B1 (en) | 2002-09-20 | 2003-08-19 | Angel Medical Systems, Inc. | System for the detection of cardiac events |
US7128727B2 (en) | 2002-09-30 | 2006-10-31 | Flaherty J Christopher | Components and methods for patient infusion device |
US7144384B2 (en) | 2002-09-30 | 2006-12-05 | Insulet Corporation | Dispenser components and methods for patient infusion device |
US20040099593A1 (en) | 2002-11-25 | 2004-05-27 | Potito De Paolis | Concurrent dialysate purification cartridge |
US9700663B2 (en) | 2005-01-07 | 2017-07-11 | Nxstage Medical, Inc. | Filtration system for preparation of fluids for medical applications |
ATE434454T1 (de) | 2003-01-07 | 2009-07-15 | Nxstage Medical Inc | Chargenfiltriersystem zur herstellung einer sterilen ersatzflüssigkeit für nierenbehandlungen |
US7276042B2 (en) | 2003-01-23 | 2007-10-02 | National Quality Care, Inc. | Low hydraulic resistance cartridge |
EP1590659A4 (en) | 2003-02-07 | 2010-04-21 | Univ Texas | MULTILOSE MICROSPHERE WITH INTEGRATED CHROMATOGRAPHIC AND DETECTION LAYERS FOR USE IN ARRAY SENSORS |
AU2003900572A0 (en) | 2003-02-10 | 2003-02-20 | Metal Storm Limited | Electronically selectable kinetic energy projectile |
US7330750B2 (en) | 2003-04-25 | 2008-02-12 | Instrumentarium Corp. | Estimation of cardiac death risk |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
DE10339342B3 (de) | 2003-08-25 | 2005-01-20 | Fresenius Medical Care Deutschland Gmbh | Blutbehandlungsvorrichtung |
US8026729B2 (en) | 2003-09-16 | 2011-09-27 | Cardiomems, Inc. | System and apparatus for in-vivo assessment of relative position of an implant |
US8086323B2 (en) | 2003-09-23 | 2011-12-27 | Medtronic Minimed, Inc. | Implantable multi-parameter sensing system and method |
US20050065760A1 (en) | 2003-09-23 | 2005-03-24 | Robert Murtfeldt | Method for advising patients concerning doses of insulin |
AU2004279280B2 (en) | 2003-10-13 | 2009-11-26 | Fresenius Medical Care Deutschland Gmbh | A device for carrying out a peritoneal dialysis treatment |
SE0302698L (sv) | 2003-10-13 | 2005-04-14 | Gambro Lundia Ab | Anordning för genomförande av en peritonealdialys -behandling |
EP2368589B1 (en) | 2003-10-28 | 2016-08-03 | Baxter International Inc. | Apparatuses for medical fluid systems |
US8029454B2 (en) | 2003-11-05 | 2011-10-04 | Baxter International Inc. | High convection home hemodialysis/hemofiltration and sorbent system |
US7651868B2 (en) | 2003-12-11 | 2010-01-26 | The Board Of Regents Of The University Of Texas System | Method and system for the analysis of saliva using a sensor array |
US7744553B2 (en) | 2003-12-16 | 2010-06-29 | Baxter International Inc. | Medical fluid therapy flow control systems and methods |
CN1897993B (zh) | 2003-12-24 | 2012-02-08 | 凯米卡技术有限公司 | 用于便携式人类透析的透析液再生系统 |
CA2555807A1 (en) * | 2004-02-12 | 2005-08-25 | Biopeak Corporation | Non-invasive method and apparatus for determining a physiological parameter |
DE102004013814A1 (de) | 2004-03-20 | 2005-10-13 | B. Braun Medizintechnologie Gmbh | Verfahren zur Gestattung von Bedienereingaben an einem medizinischen Gerät |
US20050234354A1 (en) | 2004-04-15 | 2005-10-20 | Rowlandson G I | System and method for assessing a patient's risk of sudden cardiac death |
US7509159B2 (en) | 2004-04-15 | 2009-03-24 | Ge Medical Systems Information Technologies, Inc. | Method and apparatus for detecting cardiac repolarization abnormality |
US7247493B2 (en) | 2004-05-18 | 2007-07-24 | Virbac Corporation | Reusable pH sensor device and related methods |
EP1784248B1 (en) | 2004-06-09 | 2014-07-30 | Renal Solutions, Inc. | Dialysis system |
ITMO20040191A1 (it) | 2004-07-23 | 2004-10-23 | Gambro Lundia Ab | Macchina e metodo per il trattamento extracorporeo di sangue. |
US7373195B2 (en) * | 2004-07-30 | 2008-05-13 | Medtronic, Inc. | Ion sensor for long term use in complex medium |
US7356366B2 (en) * | 2004-08-02 | 2008-04-08 | Cardiac Pacemakers, Inc. | Device for monitoring fluid status |
US8202248B2 (en) | 2004-08-18 | 2012-06-19 | Sequana Medical Ag | Dialysis implant and methods of use |
JP4094600B2 (ja) * | 2004-10-06 | 2008-06-04 | 日機装株式会社 | 血液浄化装置 |
CN103357450B (zh) | 2004-12-28 | 2016-08-10 | 雷纳尔溶液公司 | 合成磷酸锆颗粒的方法 |
US7756572B1 (en) | 2005-01-25 | 2010-07-13 | Pacesetter, Inc. | System and method for efficiently distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device and an external system |
WO2006086490A1 (en) | 2005-02-07 | 2006-08-17 | Medtronic, Inc. | Ion imbalance detector |
US20060195064A1 (en) | 2005-02-28 | 2006-08-31 | Fresenius Medical Care Holdings, Inc. | Portable apparatus for peritoneal dialysis therapy |
US7404799B1 (en) | 2005-04-05 | 2008-07-29 | Pacesetter, Inc. | System and method for detection of respiration patterns via integration of intracardiac electrogram signals |
US7537569B2 (en) | 2005-04-29 | 2009-05-26 | Medtronic, Inc. | Method and apparatus for detection of tachyarrhythmia using cycle lengths |
US20060257500A1 (en) * | 2005-05-05 | 2006-11-16 | Duke University | TRPC6 involved in glomerulonephritis |
WO2006120415A1 (en) | 2005-05-06 | 2006-11-16 | Imi Vision Limited | Dialysis machine |
US7699833B2 (en) | 2005-05-06 | 2010-04-20 | Moberg Sheldon B | Pump assembly and method for infusion device |
JP4452660B2 (ja) | 2005-06-28 | 2010-04-21 | トヨタ自動車株式会社 | ノッキング状態判定装置 |
US20070007184A1 (en) | 2005-07-07 | 2007-01-11 | Delphi Technologies, Inc. | Specialized sensor-assisted dialysis |
US20070031972A1 (en) | 2005-08-05 | 2007-02-08 | Attar Amir J | Detection of poisons in materials such as food using colorimetric detection |
US7529580B2 (en) | 2005-08-11 | 2009-05-05 | Pacesetter, Inc. | Detection of renal failure by cardiac implantable medical device |
US7674231B2 (en) | 2005-08-22 | 2010-03-09 | Massachusetts Institute Of Technology | Wearable pulse wave velocity blood pressure sensor and methods of calibration thereof |
US7775983B2 (en) | 2005-09-16 | 2010-08-17 | Cardiac Pacemakers, Inc. | Rapid shallow breathing detection for use in congestive heart failure status determination |
US8372025B2 (en) * | 2005-09-22 | 2013-02-12 | Baxter International Inc. | Automation and optimization of CRRT treatment using regional citrate anticoagulation |
US7658884B2 (en) | 2005-10-05 | 2010-02-09 | Swan Analytische Instrumente Ag | Photometric method and apparatus for measuring a liquid's turbidity, fluorescence, phosphorescence and/or absorption coefficient |
US20100137693A1 (en) | 2005-11-01 | 2010-06-03 | Fresenius Medical Care Holdings, Inc. | Methods and systems for patient care |
JP4822258B2 (ja) * | 2005-11-11 | 2011-11-24 | 日機装株式会社 | 血液透析装置 |
DE102005060866B4 (de) | 2005-12-20 | 2009-01-15 | Bruker Biospin Gmbh | Kombinierte Titrations- und pH-Elektrode für die Präparation von flüssigen Messproben insbesondere für die NMR-Spektroskopie |
JP4994391B2 (ja) | 2005-12-29 | 2012-08-08 | フレックスダイアリシス エーピーエス | 家庭透析システム |
US8409864B2 (en) | 2006-01-06 | 2013-04-02 | Renal Solutions, Inc. | Ammonia sensor and system for use |
US8187250B2 (en) | 2006-01-30 | 2012-05-29 | The Regents Of The University Of California | Peritoneal dialysis methods and apparatus |
US8246563B2 (en) * | 2006-02-02 | 2012-08-21 | Cardiac Pacemakers, Inc. | Cardiac rhythm management device and sensor-suite for the optimal control of ultrafiltration and renal replacement therapies |
US7842243B2 (en) | 2006-02-21 | 2010-11-30 | Sergey Sergeyevich Sarkisov | Chemical sensor with an indicator dye |
US8012118B2 (en) * | 2006-03-08 | 2011-09-06 | Fresenius Medical Care Holdings, Inc. | Artificial kidney dialysis system |
US7785463B2 (en) | 2006-03-17 | 2010-08-31 | Children's Hospital Medical Center | Extracorporeal renal replacement modeling system |
JP2007255995A (ja) | 2006-03-22 | 2007-10-04 | Nec Corp | 色識別装置およびガス特定装置 |
US7610086B1 (en) | 2006-03-31 | 2009-10-27 | Pacesetter, Inc. | System and method for detecting cardiac ischemia in real-time using a pattern classifier implemented within an implanted medical device |
WO2007115321A2 (en) | 2006-04-04 | 2007-10-11 | Photonic Biosystems, Inc. | Visual, continuous and simultaneous measurement of solution ammonia and hydrogen ion concentration |
US8366316B2 (en) | 2006-04-14 | 2013-02-05 | Deka Products Limited Partnership | Sensor apparatus systems, devices and methods |
US20080058697A1 (en) | 2006-04-14 | 2008-03-06 | Deka Products Limited Partnership | Heat exchange systems, devices and methods |
US20070255125A1 (en) | 2006-04-28 | 2007-11-01 | Moberg Sheldon B | Monitor devices for networked fluid infusion systems |
US7558622B2 (en) | 2006-05-24 | 2009-07-07 | Bao Tran | Mesh network stroke monitoring appliance |
US8496809B2 (en) | 2006-06-05 | 2013-07-30 | Baxter International Inc. | Dynamic weight balancing of flow in kidney failure treatment systems |
CN101460092B (zh) * | 2006-06-07 | 2011-06-01 | 甘布罗伦迪亚股份公司 | 快速症状性血压降低的预测 |
DE102006028172A1 (de) | 2006-06-16 | 2007-12-20 | Universität Hannover | Verfahren und Vorrichtung zur Elimination von Arsen aus Wasser |
US7572232B2 (en) | 2006-07-24 | 2009-08-11 | Cardiac Pacemakers, Inc. | Cardiac signal display and event detection using multiresolution Z-score transform |
WO2008097268A2 (en) | 2006-07-26 | 2008-08-14 | Detectachem, Llc. | Apparatus and method for detection of trace chemicals |
SE532971C2 (sv) | 2006-08-16 | 2010-05-25 | Triomed Ab | System för regenerering av en vätska |
US7887502B2 (en) | 2006-09-15 | 2011-02-15 | University Of Florida Research Foundation, Inc. | Method for using photoplethysmography to optimize fluid removal during renal replacement therapy by hemodialysis or hemofiltration |
WO2008036011A1 (en) | 2006-09-19 | 2008-03-27 | Gambro Lundia Ab | Estimation of propensity to symptomatic hypotension |
DE102006045437A1 (de) | 2006-09-26 | 2008-04-03 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung und Verfahren zur Vorgabe einer Dialysierflüssigkeitsrate oder Blutflussrate für eine extrakorporale Blutbehandlung |
EP2086632B1 (en) | 2006-10-19 | 2017-05-03 | Second Sight Medical Products, Inc. | Visual prosthesis |
DE102006050272B4 (de) | 2006-10-23 | 2008-07-24 | Fresenius Medical Care Deutschland Gmbh | Hämodialysegerät, Hämodiafiltrationsgerät, Verfahren zur Probennahme bei solchen Geräten und Probenentnahmeset zur Anwendung bei solchen Geräten und Verfahren |
WO2008052358A1 (en) | 2006-11-03 | 2008-05-08 | The Governors Of The University Of Alberta | Microfluidic device having an array of spots |
US9968266B2 (en) | 2006-12-27 | 2018-05-15 | Cardiac Pacemakers, Inc. | Risk stratification based heart failure detection algorithm |
US8183046B2 (en) | 2007-01-11 | 2012-05-22 | The Board Of Trustees Of The University Of Illinois | Temperature resistant pH buffers for use at low temperatures |
US7731689B2 (en) | 2007-02-15 | 2010-06-08 | Baxter International Inc. | Dialysis system having inductive heating |
US8202241B2 (en) | 2007-02-15 | 2012-06-19 | Asahi Kasei Medical Co., Ltd. | Blood purification system |
US8042563B2 (en) | 2007-02-27 | 2011-10-25 | Deka Products Limited Partnership | Cassette system integrated apparatus |
US8409441B2 (en) | 2007-02-27 | 2013-04-02 | Deka Products Limited Partnership | Blood treatment systems and methods |
EP4309691A2 (en) | 2007-02-27 | 2024-01-24 | DEKA Products Limited Partnership | Hemodialysis systems |
US8366655B2 (en) | 2007-02-27 | 2013-02-05 | Deka Products Limited Partnership | Peritoneal dialysis sensor apparatus systems, devices and methods |
US8491184B2 (en) | 2007-02-27 | 2013-07-23 | Deka Products Limited Partnership | Sensor apparatus systems, devices and methods |
CA2684807A1 (en) | 2007-04-05 | 2008-10-16 | Velomedix, Inc. | Automated therapy system and method |
US7775986B2 (en) | 2007-04-10 | 2010-08-17 | B. Braun Medizintechnologie Gmbh | Therapy device with a time-variable blood regulation |
CN101778646B (zh) | 2007-05-29 | 2013-01-30 | 弗雷塞尼斯医疗保健控股公司 | 溶液、透析液及相关方法 |
EP2171053B1 (en) | 2007-07-20 | 2014-04-23 | Mayo Foundation for Medical Education and Research | Natriuretic polypeptides |
US7981082B2 (en) | 2007-08-21 | 2011-07-19 | Hospira, Inc. | System and method for reducing air bubbles in a fluid delivery line |
DE102007039939B4 (de) | 2007-08-23 | 2013-03-14 | Albutec Gmbh | Vorrichtung zur Einsparung von Diafiltrat |
AT505690B1 (de) | 2007-08-31 | 2012-09-15 | Zentrum Fuer Biomedizinische Technologie Der Donau Uni Krems | Verfahren zum erfassen der ionenkonzentration bei citrat-antikoagulierter extrakorporaler blutreinigung |
US20090101577A1 (en) | 2007-09-28 | 2009-04-23 | Fulkerson Barry N | Methods and Systems for Controlling Ultrafiltration Using Central Venous Pressure Measurements |
DE102007052571A1 (de) * | 2007-11-03 | 2009-05-07 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zur Überwachung der Zufuhr von Substitutionsflüssigkeit während einer extrakorporalen Blutbehandlung |
TWI400062B (zh) | 2007-11-08 | 2013-07-01 | 私立中原大學 | Medical devices that record physiological signals |
US9415150B2 (en) | 2007-11-09 | 2016-08-16 | Baxter Healthcare S.A. | Balanced flow dialysis machine |
US8889004B2 (en) | 2007-11-16 | 2014-11-18 | Fresenius Medical Care Holdings, Inc. | Dialysis systems and methods |
US8580112B2 (en) | 2007-11-16 | 2013-11-12 | Fresenius Medical Care Holdings, Inc. | Dialysis systems and methods |
CA3057807C (en) | 2007-11-29 | 2021-04-20 | Thomas P. Robinson | System and method for conducting hemodialysis and hemofiltration |
US20090149776A1 (en) | 2007-12-05 | 2009-06-11 | Adams Scott C | Optical sensor for detecting infection and other anomalous conditions associated with catheter systems |
CN101482572B (zh) | 2008-01-11 | 2012-07-04 | 株式会社东芝 | 自动分析装置以及自动分析方法 |
CN102046260B (zh) | 2008-01-18 | 2014-09-24 | 弗雷塞尼斯医疗保健控股公司 | 从透析装置的流体回路中除去二氧化碳气体 |
CA2712945C (en) | 2008-01-23 | 2017-06-06 | Deka Products Limited Partnership | Pump cassette and methods for use in medical treatment system using a plurality of fluid lines |
WO2009094035A1 (en) | 2008-01-25 | 2009-07-30 | Fresenius Medical Care Holdings, Inc. | Apparatus and methods for early stage peritonitis detection and for in vivo testing of bodily fluids |
WO2009094700A1 (en) * | 2008-01-31 | 2009-08-06 | Applied Physiology Pty. Ltd. | Systems, methods and devices for maintenance, guidance and/or control |
US8019406B2 (en) | 2008-03-10 | 2011-09-13 | Biotronik Crm Patent Ag | Apparatus and method to assess the risk of R-on-T event |
JP2009247724A (ja) * | 2008-04-09 | 2009-10-29 | Jms Co Ltd | 血液透析装置 |
US20090264776A1 (en) | 2008-04-17 | 2009-10-22 | Terence Vardy | Measurement of physiological characteristics |
WO2009132839A1 (en) | 2008-04-30 | 2009-11-05 | Gambro Lundia Ab | Hydrophobic deaeration membrane |
US8882700B2 (en) | 2008-05-02 | 2014-11-11 | Baxter International Inc. | Smart patient transfer set for peritoneal dialysis |
US8233973B2 (en) | 2008-05-02 | 2012-07-31 | Spacelabs Healthcare, Llc | Methods for detection of cardiac arrhythmias |
US8449495B2 (en) | 2008-05-28 | 2013-05-28 | Baxter Healthcare Inc. | Dialysis system having automated effluent sampling and peritoneal equilibration test |
US8220643B2 (en) | 2008-06-06 | 2012-07-17 | Fresenius Medical Care Holdings, Inc. | Urea sorbent |
ES2821448T3 (es) | 2008-06-23 | 2021-04-26 | Temasek Polytechnic | Sorbente para un dispositivo de diálisis |
US9821105B2 (en) | 2008-07-01 | 2017-11-21 | Baxter International Inc. | Nanoclay sorbents for dialysis |
US9147045B2 (en) | 2008-07-09 | 2015-09-29 | Baxter International Inc. | Peritoneal equilibration test and dialysis system using same |
US8057679B2 (en) | 2008-07-09 | 2011-11-15 | Baxter International Inc. | Dialysis system having trending and alert generation |
US8696626B2 (en) | 2008-07-30 | 2014-04-15 | Claudia F. E. Kirsch | Debubbler |
CN101644667A (zh) | 2008-08-05 | 2010-02-10 | 长春吉大·小天鹅仪器有限公司 | 茶叶质量安全快速检测仪 |
US20100051552A1 (en) | 2008-08-28 | 2010-03-04 | Baxter International Inc. | In-line sensors for dialysis applications |
EP2163272B1 (en) * | 2008-09-15 | 2014-06-25 | B. Braun Avitum AG | Device to early predict the Kt/V parameter in kidney substitution treatments |
JP2012502734A (ja) * | 2008-09-19 | 2012-02-02 | カーディアック ペースメイカーズ, インコーポレイテッド | 中心静脈圧力センサおよび水分または容量過負荷治療を制御する方法 |
EP2361035B1 (en) * | 2008-09-19 | 2014-12-31 | Cardiac Pacemakers, Inc. | System for determining a heart failure status |
WO2010039384A2 (en) | 2008-09-30 | 2010-04-08 | Fresenius Medical Care Holdings, Inc. | Covalently immobilized enzyme and method to make the same |
US8409444B2 (en) | 2008-09-30 | 2013-04-02 | Fresenius Medical Care Holdings, Inc. | Acid zirconium phosphate and alkaline hydrous zirconium oxide materials for sorbent dialysis |
AU2009298636B2 (en) | 2008-10-03 | 2013-12-05 | Fresenius Medical Care Holdings, Inc. | Zirconium phosphate particles having improved adsorption capacity and method of synthesizing the same |
US9883799B2 (en) | 2008-10-16 | 2018-02-06 | Fresenius Medical Care Holdings, Inc. | Method of identifying when a patient undergoing hemodialysis is at increased risk of death |
JP5551709B2 (ja) | 2008-11-03 | 2014-07-16 | フレゼニウス メディカル ケア ホールディングス インコーポレイテッド | 携帯型腹膜透析システム |
US9370324B2 (en) | 2008-11-05 | 2016-06-21 | Fresenius Medical Care Holdings, Inc. | Hemodialysis patient data acquisition, management and analysis system |
DE102008061122A1 (de) | 2008-12-09 | 2010-06-17 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zum Ermitteln und/oder Überwachen eines körperlichen Zustandes, insbesondere einer kardiovaskulären Größe, eines Patienten basierend auf einer Amplitude eines Drucksignals |
US8823490B2 (en) | 2008-12-15 | 2014-09-02 | Corventis, Inc. | Patient monitoring systems and methods |
CN201342127Y (zh) | 2008-12-25 | 2009-11-11 | 贺心雅 | 在线式腹膜透析装置 |
EA201170961A1 (ru) | 2009-01-23 | 2012-02-28 | Пайонир Хай-Бред Интернэшнл, Инк. | Новый ген bacillus thuringiensis с активностью против lepidoptera |
US8521482B2 (en) | 2009-02-20 | 2013-08-27 | Baxter International Inc. | Simulation of patient drain phase in peritoneal dialysis |
EP2403554B1 (en) | 2009-03-06 | 2017-07-05 | Baxter International Inc. | Hemodialysis and peritoneal dialysis systems having electrodeionization capabilities |
US9005440B2 (en) | 2009-03-06 | 2015-04-14 | Baxter International Inc. | Hemodialysis and peritoneal dialysis systems having electrodialysis and electrodeionization capabilities |
US8480581B2 (en) * | 2009-03-24 | 2013-07-09 | Cardiac Pacemakers, Inc. | Systems and methods for anemia detection, monitoring, and treatment |
CN102361657B (zh) | 2009-03-24 | 2015-12-16 | 甘布罗伦迪亚股份公司 | 透析设备 |
DE102009018806A1 (de) | 2009-04-24 | 2010-11-25 | Fresenius Medical Care Deutschland Gmbh | Rechnersystem und Verfahren zum Erzeugen wenigstens einer maschinenlesbaren Datei für eine medizinische Behandlungsvorrichtung |
US20100298670A1 (en) * | 2009-05-20 | 2010-11-25 | Pacesetter, Inc. | Electrolyte monitoring using implanted cardiac rhythm management device |
US20100312174A1 (en) | 2009-06-06 | 2010-12-09 | Hoffman Josef C A | Peritoneal Dialysis System |
US20100312172A1 (en) | 2009-06-06 | 2010-12-09 | Hoffman Josef C A | Method of Peritoneal Dialysis |
EP2445395B1 (en) | 2009-06-26 | 2017-01-11 | Gambro Lundia AB | Devices and method for data extraction |
AU2010266335A1 (en) | 2009-07-01 | 2012-02-02 | Board Of Regents, The University Of Texas System | Methods of determining the presence and/or concentration of an analyte in a sample |
US8404091B2 (en) | 2009-08-27 | 2013-03-26 | Baxter International Inc. | Dialysis treatment devices for removing urea |
EP2292283A1 (en) | 2009-09-04 | 2011-03-09 | B. Braun Avitum AG | Method and device to obtain physiological parameters and detect clinical or subclinical abnormalities during a kidney substitution treatment |
EP2295097A1 (en) | 2009-09-09 | 2011-03-16 | Fresenius Medical Care Deutschland GmbH | Method and apparatus for evaluating values representing a mass or a concentration of a substance present within the body of a patient |
US20110066043A1 (en) | 2009-09-14 | 2011-03-17 | Matt Banet | System for measuring vital signs during hemodialysis |
US8239010B2 (en) | 2009-09-14 | 2012-08-07 | Sotera Wireless, Inc. | System for measuring vital signs during hemodialysis |
US9399091B2 (en) | 2009-09-30 | 2016-07-26 | Medtronic, Inc. | System and method to regulate ultrafiltration |
US8518260B2 (en) | 2009-10-01 | 2013-08-27 | Fresenius Medical Care Holdings, Inc. | Method of controlling diffusive sodium transport in dialysis |
EP2316334A1 (en) | 2009-10-22 | 2011-05-04 | Fresenius Medical Care Deutschland GmbH | A method for assessing a patient's fluid status and /or sensitivity to fluid removal, controller, and devices |
US20110130666A1 (en) | 2009-11-30 | 2011-06-02 | Yanting Dong | Enhanced reporting of pathological episodes |
US20110141116A1 (en) | 2009-12-16 | 2011-06-16 | Baxter International Inc. | Methods and apparatus for displaying flow rate graphs and alarms on a dialysis system |
CN101726465B (zh) | 2009-12-25 | 2011-07-06 | 重庆大学 | 微型阵列式有毒气体检测仪 |
US8845570B2 (en) * | 2010-04-16 | 2014-09-30 | Baxter International Inc. | Therapy prediction and optimization for renal failure blood therapy, especially home hemodialysis |
US9132219B2 (en) | 2010-04-16 | 2015-09-15 | Baxter International Inc. | Therapy prediction and optimization of serum potassium for renal failure blood therapy, especially home hemodialysis |
ES2387534T3 (es) | 2010-04-19 | 2012-09-25 | Gambro Lundia Ab | Aparato de diálisis |
WO2011140268A2 (en) | 2010-05-04 | 2011-11-10 | C-Tech Biomedical, Inc. | Dual mode hemodialysis machine |
CN101958264B (zh) | 2010-05-06 | 2012-06-20 | 东莞宏威数码机械有限公司 | 无尘式真空动力传送装置 |
EP2388030B2 (en) | 2010-05-20 | 2022-03-16 | B. Braun Avitum AG | Kidney substitution device to automate blood sampling procedure in a kidney substitution treatment machine |
DE102010022201A1 (de) | 2010-05-20 | 2011-11-24 | Fresenius Medical Care Deutschland Gmbh | Medizinische Behandlungsanordnung |
US9145318B2 (en) | 2010-05-24 | 2015-09-29 | Baxter International Inc. | Systems and methods for removing hydrogen peroxide from water purification systems |
US20110301447A1 (en) | 2010-06-07 | 2011-12-08 | Sti Medical Systems, Llc | Versatile video interpretation, visualization, and management system |
JP5876042B2 (ja) | 2010-06-23 | 2016-03-02 | ガンブロ・ルンディア・エービーGambro Lundia Ab | 透析前駆体組成物 |
US8395213B2 (en) | 2010-08-27 | 2013-03-12 | Acorn Technologies, Inc. | Strained semiconductor using elastic edge relaxation of a stressor combined with buried insulating layer |
JP5961168B2 (ja) | 2010-09-07 | 2016-08-02 | ネクストテック エルエルシー | 比色管を視覚的および電子的に読み取るためのシステム |
WO2012038384A1 (en) * | 2010-09-20 | 2012-03-29 | Gambro Lundia Ab | Obtaining control settings for a dialysis machine |
ES2498744T3 (es) | 2010-09-27 | 2014-09-25 | Gambro Lundia Ab | Aparato para el tratamiento extracorpóreo de sangre |
US8784668B2 (en) | 2010-10-12 | 2014-07-22 | Fresenius Medical Care Holdings, Inc. | Systems and methods for compensation of compliant behavior in regenerative dialysis systems |
DE102010048771A1 (de) | 2010-10-14 | 2012-05-16 | B. Braun Avitum Ag | Verfahren und Vorrichtung zur Messung und Behebung von Systemänderungen in einer Vorrichtung zur Behandlung von Blut |
JP4803318B1 (ja) | 2010-12-02 | 2011-10-26 | 横浜ゴム株式会社 | 空気入りタイヤ |
EP2654825B1 (en) | 2010-12-20 | 2017-08-02 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
DE102011008185A1 (de) | 2011-01-10 | 2012-07-12 | Fresenius Medical Care Deutschland Gmbh | Herstellung von Individualkonzentrat |
DE102011003720A1 (de) | 2011-02-07 | 2012-08-09 | Robert Bosch Gmbh | Anordnung und Verfahren zum Detektieren von Wasserstoffperoxid |
EP2678028A2 (en) | 2011-02-25 | 2014-01-01 | Medtronic, Inc. | Systems and methods for therapy of kidney disease and/or heart failure using chimeric natriuretic peptides |
ITMI20110441A1 (it) | 2011-03-21 | 2012-09-22 | Gambro Lundia Ab | Apparecchiatura per il trattamento extracorporeo di sangue. |
CN202048893U (zh) | 2011-03-21 | 2011-11-23 | 东华大学 | 一种纺丝溶液气泡实时检测系统 |
WO2012129501A2 (en) | 2011-03-23 | 2012-09-27 | Nxstage Medical, Inc. | Peritoneal dialysis systems, devices, and methods |
US8945936B2 (en) | 2011-04-06 | 2015-02-03 | Fresenius Medical Care Holdings, Inc. | Measuring chemical properties of a sample fluid in dialysis systems |
US20120258546A1 (en) | 2011-04-08 | 2012-10-11 | Life Technologies Corporation | Automated On-Instrument pH Adjustment |
US9320842B2 (en) | 2011-04-29 | 2016-04-26 | Medtronic, Inc. | Multimodal dialysis system |
US9456755B2 (en) | 2011-04-29 | 2016-10-04 | Medtronic, Inc. | Method and device to monitor patients with kidney disease |
US8951219B2 (en) | 2011-04-29 | 2015-02-10 | Medtronic, Inc. | Fluid volume monitoring for patients with renal disease |
EP2701580B1 (en) | 2011-04-29 | 2020-12-30 | Medtronic, Inc. | Device to monitor patients with kidney disease |
US9848778B2 (en) | 2011-04-29 | 2017-12-26 | Medtronic, Inc. | Method and device to monitor patients with kidney disease |
WO2012148781A1 (en) | 2011-04-29 | 2012-11-01 | Medtronic, Inc. | Multimodal dialysis system |
US9132217B2 (en) | 2011-04-29 | 2015-09-15 | Medtronic, Inc. | Multimodal dialysis system |
US20120303079A1 (en) | 2011-05-23 | 2012-11-29 | Deepa Mahajan | Apparatus and method for combined cardiac function management and renal therapies |
WO2012162515A2 (en) | 2011-05-24 | 2012-11-29 | Deka Products Limited Partnership | Hemodial ysis system |
ES2562466T3 (es) | 2011-07-29 | 2016-03-04 | Baxter International Inc. | Gestión de sodio para sistemas de diálisis |
EP3165245B1 (en) | 2011-08-02 | 2019-02-20 | Medtronic, Inc. | Hemodialysis system having a flow path with a controlled compliant volume |
WO2013022760A1 (en) | 2011-08-05 | 2013-02-14 | Alere San Diego, Inc. | Methods and compositions for monitoring heart failure |
EP2744537B1 (en) | 2011-08-16 | 2018-01-24 | Medtronic, Inc. | Modular hemodialysis system |
CN103842004B (zh) | 2011-08-22 | 2016-11-23 | 美敦力公司 | 双流吸附剂盒 |
US8811290B2 (en) | 2011-09-29 | 2014-08-19 | Lg Electronics Inc. | Method and apparatus for transmitting paging message in wireless communication system |
AU2012336423B2 (en) | 2011-11-08 | 2017-08-03 | Temasek Polytechnic | Sensing system for detecting a substance in a dialysate |
JP5099464B1 (ja) | 2011-12-29 | 2012-12-19 | 富田製薬株式会社 | 重炭酸イオン濃度可変型の透析液の調製装置及び調製方法、重炭酸イオン濃度可変型の透析剤、並びに重炭酸イオン濃度可変型の透析システム |
EP2800591B1 (en) | 2012-01-04 | 2016-01-13 | Fresenius Medical Care Holdings, Inc. | Method and system of enhancing removal of toxic anions and organic solutes in sorbent dialysis |
US9713668B2 (en) | 2012-01-04 | 2017-07-25 | Medtronic, Inc. | Multi-staged filtration system for blood fluid removal |
GB201201330D0 (en) | 2012-01-26 | 2012-03-14 | Quanta Fluid Solutions Ltd | Dialysis machine |
US20140276100A1 (en) | 2012-02-01 | 2014-09-18 | Invoy Technologies | System for measuring breath analytes |
WO2013114063A1 (en) | 2012-02-02 | 2013-08-08 | Quanta Fluid Solutions Ltd. | Dialysis machine |
WO2013121162A1 (en) | 2012-02-14 | 2013-08-22 | Quanta Fluid Solutions Ltd | Dialysis machine |
ES2570804T3 (es) | 2012-03-21 | 2016-05-20 | Gambro Lundia Ab | Suministro de solución de tratamiento en un aparato de tratamiento extracorpóreo de sangre |
EP3222306B1 (en) | 2012-03-23 | 2018-11-14 | NxStage Medical, Inc. | Peritoneal dialysis systems and devices |
US9610392B2 (en) | 2012-06-08 | 2017-04-04 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
US9500188B2 (en) | 2012-06-11 | 2016-11-22 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
DE102012014504A1 (de) | 2012-07-20 | 2014-01-23 | Dräger Safety AG & Co. KGaA | Gasmesssystem |
US9231692B2 (en) | 2012-09-04 | 2016-01-05 | Viasat Inc. | Paired-beam transponder satellite communication |
US9162021B2 (en) | 2012-10-22 | 2015-10-20 | Baxter International Inc. | Integrated water testing system and method for ultra-low total chlorine detection |
US9138520B2 (en) | 2012-10-22 | 2015-09-22 | Baxter International Inc. | Total chlorine water detection system and method for medical fluid treatments |
US9523642B2 (en) | 2012-11-09 | 2016-12-20 | Taiwan Semiconductor Manufacturing Company, Ltd. | Integrated electro-microfluidic probe card, system and method for using the same |
JP2014097224A (ja) | 2012-11-15 | 2014-05-29 | Tatsunori Kato | 透析ユニットおよびアクセス再循環率の測定方法 |
US10905816B2 (en) | 2012-12-10 | 2021-02-02 | Medtronic, Inc. | Sodium management system for hemodialysis |
US20140158588A1 (en) | 2012-12-10 | 2014-06-12 | Medtronic, Inc. | pH AND BUFFER MANAGEMENT SYSTEM FOR HEMODIALYSIS SYSTEMS |
US9399090B2 (en) | 2012-12-10 | 2016-07-26 | Medtronic, Inc. | Potassium loaded ion-exchange material for use in a dialysate regeneration system |
CN103901025A (zh) | 2012-12-27 | 2014-07-02 | 中国科学院烟台海岸带研究所 | 一种便携式纸基微流控芯片色彩检测装置和方法 |
US9707328B2 (en) | 2013-01-09 | 2017-07-18 | Medtronic, Inc. | Sorbent cartridge to measure solute concentrations |
US10010663B2 (en) | 2013-02-01 | 2018-07-03 | Medtronic, Inc. | Fluid circuit for delivery of renal replacement therapies |
US9526822B2 (en) | 2013-02-01 | 2016-12-27 | Medtronic, Inc. | Sodium and buffer source cartridges for use in a modular controlled compliant flow path |
WO2014121161A1 (en) | 2013-02-01 | 2014-08-07 | Medtronic, Inc. | Recirculating dialysate fluid circuit for blood measurement |
US9173987B2 (en) | 2013-02-01 | 2015-11-03 | Medtronic, Inc. | Degassing module for a controlled compliant flow path |
WO2014121162A1 (en) | 2013-02-01 | 2014-08-07 | Medtronic, Inc. | Sorbent cartridge to measure solute concentrations |
US9827361B2 (en) | 2013-02-02 | 2017-11-28 | Medtronic, Inc. | pH buffer measurement system for hemodialysis systems |
US9144640B2 (en) | 2013-02-02 | 2015-09-29 | Medtronic, Inc. | Sorbent cartridge configurations for improved dialysate regeneration |
BR112015022195A8 (pt) | 2013-03-14 | 2019-11-26 | Baxter Healthcare Sa | sistema e método de diálise peritoneal, instalação para proporcionar trocas de diálise peritoneal, e instalação walk-in |
CN103439230B (zh) | 2013-09-13 | 2015-07-01 | 山东省科学院海洋仪器仪表研究所 | 一种气泡参数测量方法及测量装置 |
EP3102107A4 (en) | 2013-11-04 | 2018-02-07 | Medtronic, Inc. | Method and device to manage fluid volumes in the body |
US9884145B2 (en) | 2013-11-26 | 2018-02-06 | Medtronic, Inc. | Parallel modules for in-line recharging of sorbents using alternate duty cycles |
WO2015081221A1 (en) | 2013-11-27 | 2015-06-04 | Medtronic, Inc. | Precision dialysis monitoring and synchonization system |
SE538124C2 (sv) | 2014-02-28 | 2016-03-08 | Triomed Ab | Apparat för peritoneal ultrafiltration innefattande kontrollav glukoskoncentrationen i peritonealhålan |
WO2015159280A1 (en) | 2014-04-13 | 2015-10-22 | Spectrophon Ltd | Wireless colorimetric sensor |
MX2016015466A (es) | 2014-05-29 | 2017-03-23 | Fresenius Medical Care Holdings Inc | Metodo para tratar dializado, sistema de dialisis y metodo para pre-evaluar pacientes de dialisis para el tratamiento con los mismos. |
US9278536B2 (en) | 2014-07-22 | 2016-03-08 | Xyzprinting, Inc. | Printing head module |
US10576195B2 (en) | 2014-11-21 | 2020-03-03 | Triomed Ab | Apparatus for performing peritoneal ultrafiltration |
US9895479B2 (en) | 2014-12-10 | 2018-02-20 | Medtronic, Inc. | Water management system for use in dialysis |
ES2869892T3 (es) | 2014-12-17 | 2021-10-26 | Newsol Tech Inc | Sistema y método para diálisis peritoneal |
CN104833635B (zh) | 2015-04-23 | 2018-03-16 | 东北大学 | 一种检测葡萄糖浓度的微型石英空心管复合光纤结构 |
SE539744C2 (en) | 2015-08-27 | 2017-11-14 | Triomed Ab | PERFORMING PERITONEAL ULTRAFILTRATION APPLIANCE |
CN105115921B (zh) | 2015-09-09 | 2017-10-20 | 浙江大学 | 一种用于检测水中气体浓度的检测装置 |
CN105692957B (zh) | 2016-02-26 | 2018-11-13 | 宁波惠士康健康科技有限公司 | 具有杀菌功能的净水器 |
AU2017246829A1 (en) | 2016-04-04 | 2018-11-15 | Medtronic, Inc. | Peritoneal dialysate fluid generation system with integrated cycler |
US20170281847A1 (en) | 2016-04-04 | 2017-10-05 | Medtronic, Inc. | Regenerative peritoneal dialysis system |
CN205672288U (zh) | 2016-04-08 | 2016-11-09 | 福州东泽医疗器械有限公司 | 一种自动腹膜透析机加热及温控系统 |
US10716886B2 (en) | 2016-05-06 | 2020-07-21 | Gambro Lundia Ab | Systems and methods for peritoneal dialysis having point of use dialysis fluid preparation including testing thereof |
CN106124491A (zh) | 2016-06-15 | 2016-11-16 | 安徽有果信息技术服务有限公司 | 一种甲醛生产在线浓度检测技术 |
CN109562216A (zh) | 2016-08-10 | 2019-04-02 | 美敦力股份有限公司 | 导管和腹膜健康监测 |
-
2012
- 2012-03-20 US US13/424,454 patent/US8951219B2/en active Active
- 2012-03-20 US US13/424,490 patent/US9061099B2/en active Active
- 2012-03-20 US US13/424,517 patent/US9302036B2/en active Active
- 2012-03-20 US US13/424,467 patent/US8926542B2/en active Active
- 2012-03-20 US US13/424,533 patent/US9750862B2/en active Active
- 2012-03-20 US US13/424,479 patent/US9192707B2/en active Active
- 2012-03-20 US US13/424,429 patent/US9561316B2/en active Active
- 2012-03-20 US US13/424,525 patent/US9700661B2/en active Active
- 2012-04-19 WO PCT/US2012/034333 patent/WO2012148789A1/en active Application Filing
- 2012-04-19 EP EP12717020.7A patent/EP2701760B1/en active Active
- 2012-04-19 WO PCT/US2012/034332 patent/WO2012148788A1/en active Application Filing
- 2012-04-19 WO PCT/US2012/034334 patent/WO2012148790A1/en active Application Filing
- 2012-04-19 EP EP12717021.5A patent/EP2701766A1/en not_active Withdrawn
- 2012-04-19 CN CN201280020933.6A patent/CN103747816B/zh active Active
- 2012-04-19 EP EP12719842.2A patent/EP2701764B1/en active Active
- 2012-04-19 JP JP2014508436A patent/JP5837679B2/ja active Active
- 2012-04-19 EP EP12722951.6A patent/EP2701596B1/en active Active
- 2012-04-19 EP EP21184573.0A patent/EP3932444A1/en not_active Withdrawn
- 2012-04-19 CN CN201510511657.9A patent/CN105169509B/zh active Active
- 2012-04-19 WO PCT/US2012/034327 patent/WO2013101292A2/en active Application Filing
- 2012-04-19 CN CN201280020938.9A patent/CN103747731B/zh active Active
- 2012-04-19 JP JP2014508435A patent/JP6153923B2/ja not_active Expired - Fee Related
- 2012-04-19 CN CN201280020932.1A patent/CN103717132B/zh active Active
- 2012-04-19 JP JP2014508434A patent/JP2014518688A/ja active Pending
- 2012-04-19 WO PCT/US2012/034331 patent/WO2012148787A1/en active Application Filing
- 2012-04-19 CN CN201280022405.4A patent/CN103717244B/zh active Active
- 2012-04-19 JP JP2014508437A patent/JP5841238B2/ja active Active
- 2012-04-19 ES ES12717020T patent/ES2785107T3/es active Active
- 2012-04-19 EP EP12719841.4A patent/EP2701761B1/en active Active
- 2012-04-19 WO PCT/US2012/034330 patent/WO2012148786A1/en active Application Filing
- 2012-04-19 JP JP2014508433A patent/JP5705373B2/ja active Active
- 2012-04-19 CN CN201510593695.3A patent/CN105286787B/zh active Active
- 2012-04-19 CN CN201280022402.0A patent/CN103747819B/zh active Active
- 2012-04-19 EP EP12850737.3A patent/EP2701765B1/en active Active
- 2012-04-19 WO PCT/US2012/034329 patent/WO2012148785A2/en active Application Filing
- 2012-04-19 EP EP19167435.7A patent/EP3527134A1/en active Pending
- 2012-04-19 JP JP2014508438A patent/JP6138762B2/ja not_active Expired - Fee Related
- 2012-04-19 CN CN201280020937.4A patent/CN103747817B/zh active Active
- 2012-04-19 CN CN201280020931.7A patent/CN103717243B/zh active Active
- 2012-04-19 CN CN201610315692.8A patent/CN106063701A/zh active Pending
- 2012-04-19 EP EP12719170.8A patent/EP2701595B1/en active Active
- 2012-04-19 WO PCT/US2012/034335 patent/WO2012148791A1/en active Application Filing
- 2012-04-19 EP EP12717019.9A patent/EP2701759A2/en not_active Withdrawn
-
2014
- 2014-11-26 US US14/554,272 patent/US9642960B2/en active Active
- 2014-11-26 US US14/554,338 patent/US9968721B2/en active Active
-
2015
- 2015-02-04 US US14/613,725 patent/US9597440B2/en active Active
- 2015-02-24 JP JP2015033800A patent/JP2015134176A/ja active Pending
- 2015-08-18 US US14/828,990 patent/US10293092B2/en active Active
- 2015-08-18 US US14/828,979 patent/US10179198B2/en active Active
-
2016
- 2016-03-11 US US15/067,559 patent/US10406268B2/en active Active
- 2016-12-20 US US15/384,912 patent/US10064985B2/en active Active
-
2017
- 2017-05-15 JP JP2017096258A patent/JP2017176847A/ja active Pending
- 2017-05-31 JP JP2017107671A patent/JP2017164547A/ja active Pending
- 2017-09-01 US US15/693,535 patent/US10967112B2/en active Active
- 2017-09-04 JP JP2017169162A patent/JP2018008091A/ja active Pending
-
2019
- 2019-05-21 JP JP2019095089A patent/JP2019150651A/ja active Pending
-
2020
- 2020-09-28 US US17/034,250 patent/US11759557B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101193667A (zh) * | 2005-04-08 | 2008-06-04 | 日机装株式会社 | 血液透析装置和血液透析方法 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103747817B (zh) | 肾病患者的液体量监测 | |
JP2014518688A5 (zh) | ||
WO1980002376A1 (en) | Computer-controlled medical care system | |
US20220401647A1 (en) | Hemodialysis system including continuous glucose monitoring |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |