CN104000618A - Breathing movement gating correction technology implemented with ring true photon number gating method - Google Patents
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Abstract
The invention relates to a breathing movement gating correction technology implemented with a ring true photon number gating method, and belongs to the technical field of nuclear medical imaging. According to the breathing movement gating correction technology, data with PET scanning results in the list model format are obtained; the data are divided into N frames; in data in each frame, the ring true photon number of each ring in PET is counted; one frame is selected to serve as a reference frame, the ring true photon number of the reference frame is respectively compared with the ring true photon numbers of all frames, and absolute errors between the ring true photon numbers of other frames and the ring true photon number of the reference frame are obtained; one threshold value is selected, the absolute errors between the ring true photon numbers of the other frames and the ring true photon number of the reference frame are compared with the threshold value, and the frames with the absolute errors smaller than the threshold value are placed together to form new list model data; then three-dimensional reconstruction is carried out on the new list model data, and a clear PET image after gating correction is obtained. By means of the breathing movement gating correction technology, auxiliary devices are not required to be additionally arranged, algorithms are simple, automatic and independent operation is carried out, and the PET breathing movement correction efficiency is accordingly improved.
Description
Technical field
The present invention relates to the true number of photons gate control method of one ring and carry out respiratory movement gate alignment technique, belong to nuclear medicine technical field.
Background technology
Respiratory movement can cause PET(Positron Emission Tomography) and PET/CT breast abdominal part diagnostic image smudgy, thereby cause underestimating SUV(standardized uptake value) be worth and over-evaluate lesion volume, directly affect qualitative, the formulation by stages with to pathological changes radiotherapy treatment planning of clinician to thorax and abdomen malignant focus.
In order to reduce the impact of respiratory movement on PET diagnostic image, improve the degree of accuracy of PET diagnostic imaging, within the more than ten years recently, many experts, scholar further investigate and have proposed respiratory movement bearing calibration miscellaneous.Wherein respiratory movement gate control method is a kind of respiratory movement bearing calibration being most widely used.Respiratory movement gate control method can be divided into gate control method based on extraneous auxiliary device (hardware-driven) and the gate control method based on initial data (data-driven).
Gate control method based on external auxiliary device is in the time that PET scans, to monitor the changing value of one of patient or several physiological parameters by adding extraneous auxiliary device, thereby estimates respiratory movement and carry out gate correction.The auxiliary gating device in existing outside has: pneumotachograph in real time, and electrocardiogram, real time position monitoring system (RPM), pressure transducer, breathes temperature sensor etc.
Gate control method based on initial data is that initial data and the respirometric dependency relation by analyzing PET scanning carried out respiratory movement gate.The existing gate control method based on initial data has: posteriority gate control method, in the SPET of one group of 3D and PET slice of data, estimate the gate control method of rigid motion, utilize the activity of the height absorption focus (center of mass point) of moving on z axle to distribute to carry out the gate control method of motion correction, system sensitivity gate (GSG) method, optical flow method respiratory movement gate control method, region sinogram fluctuation gate (SRF) method, fragment barycenter method gate control method etc.
In existing gate control method, some gate control methods need extra interpolation auxiliary device to carry out the correction of respiratory movement gate, some gate control methods need manual going to define area-of-interest, some algorithm more complicated, what have does not utilize respiratory movement information that initial data comprises etc. fully.So cause PET or PET/CT respiratory movement to proofread and correct inefficiency, degree of accuracy is not high.
Summary of the invention
The technical problem to be solved in the present invention is: the invention provides a kind of respiratory movement gate alignment technique based on the true number of photons of ring and overcome above-mentioned existing respiratory movement alignment technique algorithm complexity, inefficiency, the problem that degree of accuracy is not high, the present invention encircles with PET the feature that respective change can occur along with the motion of lung true number of photons to carry out the technology that PET respiratory movement gate is proofreaied and correct, can effectively reduce the respiratory movement artifact of PET image, make shape, size and the position of lung tumor approach resting state.
The present invention carries out respiratory movement gate alignment technique with the true number of photons gate control method of ring and is achieved in that and first obtains the data that PET scanning result is list model format; These data are divided into N frame by a Fixed Time Interval; In the data of every frame, the true number of photons of ring to the each ring of PET under unit radioactive concentration is added up; Add up in all frames that encircle true number of photons in process, choose wherein a frame as with reference to frame, compare with the true number of photons of ring that other have added up all frames that encircle true number of photons respectively with this reference frame, draw the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of reference frame; A selected threshold value, by the absolute error of the true number of photons of ring of true ring of other frames number of photons and reference frame therewith threshold value compare, all data that meet absolute error and be less than the frame of the threshold value new list model data of formation portion of putting together; Then the new list model data obtaining is carried out to three-dimensional reconstruction, so just obtain the PET image after width gate correction clearly.
It is described that to carry out respiratory movement gate alignment technique concrete steps with the true number of photons gate control method of ring as follows:
A, obtain the data that PET scanning result is list model format; When patient carries out breast abdominal part PET scanography, the result of scanning is exported with list model data;
B, these data are divided into N frame by a Fixed Time Interval;
C, in the data of every frame, the true number of photons of ring to the each ring of PET under unit radioactive concentration is added up, M frame I encircles true number of photons=the M frame I and encircles true photon grand total/the M frame radioactive concentration;
Wherein M is in the numbering through having added up the frame that encircles true number of photons, the gauging ring numbering that I is pet scanner;
D, through having added up in all frames that encircle true number of photons, choose wherein a frame as with reference to frame, compare with the true number of photons of ring that other have added up all frames that encircle true number of photons respectively with this reference frame, draw the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of reference frame; Choose wherein a frame as with reference to frame, the optional wherein any frame added up in all frames that encircle true number of photons of a frame here;
E, a selected threshold value, by the absolute error of the true number of photons of ring of true ring of other frames number of photons and reference frame therewith threshold value compare, all data that meet absolute error and be less than the frame of the threshold value new list model data of formation portion of putting together; When selected threshold value, all absolute error value are analyzed, fitted to a curve, ask the second dervative of curve, choosing and making second dervative is that zero absolute error value is as threshold value;
F, the new list model data obtaining is carried out to three-dimensional reconstruction, so just obtain the width PET image of gate after proofreading and correct clearly;
In described step B, Fixed Time Interval can be chosen 200ms, N=PET sweep time/200ms, and N is positive integer, if being not integer, rounds to zero direction.
In described step D, concrete selection the 7th frame is reference frame, compares respectively with the 7th frame with the true number of photons of ring that other have added up all frames that encircle true number of photons, draws the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of the 7th frame:
In formula, M is in the numbering through having added up the frame that encircles true number of photons, I is the gauging ring numbering of pet scanner, DRTCE(M, I) be the true number of photons through having added up the M frame I ring that encircles true number of photons, DRTCE(7, I) for having added up in process the true number of photons of the 7th frame I gauging ring of encircling true number of photons.
It is described that to carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring be to utilize PET to encircle the feature that respective change can occur along with the motion of lung true number of photons to carry out the technology that PET respiratory movement gate is proofreaied and correct.
It is described that to carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring be the technology of carrying out the correction of respiratory movement gate by diversity of the distribution of true number of photons in each ring of analyzing and processing PET.
Principle of the present invention is: encircling true number of photons respiratory movement gate control method is to utilize positron emission computer fault-layer-phenomenon (PET) to encircle true number of photons distribution meeting along with the feature that respective change occurs in the motion of lung is carried out the correction of PET respiratory movement gate, pet scanner is mainly made up of scintillation crystal detectors (scintillation detector) and photomultiplier tube (photomultiplier tube, PMT).Multiple detectors and a ring of photomultiplier tube composition, a pet scanner of multiple ring composition.When tissue, organ scan in pet scanner, the position distribution that record meets a pair of detector of response events (line of response, LOR) has two kinds of possibilities: two detectors are all in same ring; Two detectors are in different rings.When body mould is when in pet scanner, position changes, under identical interval and unit radioactive concentration, in each ring of PET, the distribution of true number of photons (true coincidence response events number) is that respective change can occur, as shown in Figure 2, Fig. 2 is for ideally, and body mould is motion and true number of photons distribution situation accordingly thereof in pet scanner be made up of 8 rings.From the 1st frame to the 4 frames, body mould is motion from right to left in pet scanner, and each move distance is the width of a ring, and also move accordingly from right to left its position of encircling the peak value of true number of photons distribution, and each displacement is the width of a ring.In the time that cylinder moves to a certain fixing position at every turn, same time every with unit radioactive concentration under, in each ring of PET, the distribution situation of true number of photons is the same with the true number of photons distribution of the ring of cylinder in this position before or be more or less the same.So can determine that whether the position of cylinder in PET be identical or be more or less the same by whether the distribution of the true number of photons of ring of analysis PET different frame is similar.
The invention has the beneficial effects as follows: technology of the present invention does not need extra interpolation auxiliary device, simple, the automatic independent operation of algorithm, thereby improve the efficiency that PET respiratory movement is proofreaied and correct, fast operation, degree of accuracy are high, can effectively can effectively reduce motion artifacts, the respiratory movement information of utilizing fully initial data to comprise, improve the definition of PET three-dimensional reconstruction image, can measure more accurately actual size and the position of body mould, can in the clinical diagnosis work of the equipment such as PET, PET/CT, PET-CT-MRI, be widely used.
Brief description of the drawings
Fig. 1 is the flow chart in the present invention;
Fig. 2 is that the present invention is that ideally cylinder moves and corresponding true number of photons distribution situation schematic diagram in the pet scanner being made up of 8 rings;
Fig. 3 be two be synchronized with the movement and symmetrical cylinder in the true number of photons distribution situation of ring of a period of motion (5s) interior 8 different frames, the data in bracket are for taking the 7th frame as reference frame, the absolute error value drawing with the true photon ratio of each frame ring respectively;
Fig. 4 is two and is synchronized with the movement and symmetrical cylinder three-dimensional reconstruction result figure, and wherein gate image is to use the present invention to carry out the three-dimensional reconstruction image after analyzing and processing to original scan-data.
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, the invention will be further described.
Embodiment 1: as Figure 1-4, one is carried out respiratory movement gate alignment technique with the true number of photons gate control method of ring, first obtains the data that PET scanning result is list model format; These data are divided into N frame by a Fixed Time Interval; In the data of every frame, the true number of photons of ring to the each ring of PET under unit radioactive concentration is added up; Add up in all frames that encircle true number of photons in process, choose wherein a frame as with reference to frame, compare with the true number of photons of ring that other have added up all frames that encircle true number of photons respectively with this reference frame, draw the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of reference frame; A selected threshold value, by the absolute error of the true number of photons of ring of true ring of other frames number of photons and reference frame therewith threshold value compare, all data that meet absolute error and be less than the frame of the threshold value new list model data of formation portion of putting together; Then the new list model data obtaining is carried out to three-dimensional reconstruction, so just obtain the PET image after width gate correction clearly.
It is described that to carry out respiratory movement gate alignment technique concrete steps with the true number of photons gate control method of ring as follows:
A, obtain the data that PET scanning result is list model format; When patient carries out breast abdominal part PET scanography, the result of scanning is exported with list model data;
B, these data are divided into N frame by a Fixed Time Interval;
C, in the data of every frame, the true number of photons of ring to the each ring of PET under unit radioactive concentration is added up, M frame I encircles true number of photons=the M frame I and encircles true photon grand total/the M frame radioactive concentration;
Wherein M is in the numbering through having added up the frame that encircles true number of photons, the gauging ring numbering that I is pet scanner;
D, through having added up in all frames that encircle true number of photons, choose wherein a frame as with reference to frame, compare with the true number of photons of ring that other have added up all frames that encircle true number of photons respectively with this reference frame, draw the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of reference frame; Choose wherein a frame as with reference to frame, the optional wherein any frame added up in all frames that encircle true number of photons of a frame here;
E, a selected threshold value, by the absolute error of the true number of photons of ring of true ring of other frames number of photons and reference frame therewith threshold value compare, all data that meet absolute error and be less than the frame of the threshold value new list model data of formation portion of putting together; When selected threshold value, all absolute error value are analyzed, fitted to a curve, ask the second dervative of curve, choosing and making second dervative is that zero absolute error value is as threshold value;
F, the new list model data obtaining is carried out to three-dimensional reconstruction, so just obtain the width PET image of gate after proofreading and correct clearly;
In described step B, Fixed Time Interval can be chosen 200ms, N=PET sweep time/200ms, and N is positive integer, if being not integer, rounds to zero direction.
In described step D, concrete selection the 7th frame is reference frame, compares respectively with the 7th frame with the true number of photons of ring that other have added up all frames that encircle true number of photons, draws the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of the 7th frame:
In formula, M is in the numbering through having added up the frame that encircles true number of photons, I is the gauging ring numbering of pet scanner, DRTCE(M, I) be the true number of photons through having added up the M frame I ring that encircles true number of photons, DRTCE(7, I) for having added up in process the true number of photons of the 7th frame I gauging ring of encircling true number of photons.
It is described that to carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring be to utilize PET to encircle the feature that respective change can occur along with the motion of lung true number of photons to carry out the technology that PET respiratory movement gate is proofreaied and correct.
It is described that to carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring be the technology of carrying out the correction of respiratory movement gate by diversity of the distribution of true number of photons in each ring of analyzing and processing PET.
Embodiment 2: as Figure 1-4, one is carried out respiratory movement gate alignment technique with the true number of photons gate control method of ring, first obtains the data that PET scanning result is list model format; These data are divided into N frame by a Fixed Time Interval; In the data of every frame, the true number of photons of ring to the each ring of PET under unit radioactive concentration is added up; Add up in all frames that encircle true number of photons in process, choose wherein a frame as with reference to frame, compare with the true number of photons of ring that other have added up all frames that encircle true number of photons respectively with this reference frame, draw the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of reference frame; A selected threshold value, by the absolute error of the true number of photons of ring of true ring of other frames number of photons and reference frame therewith threshold value compare, all data that meet absolute error and be less than the frame of the threshold value new list model data of formation portion of putting together; Then the new list model data obtaining is carried out to three-dimensional reconstruction, so just obtain the PET image after width gate correction clearly.
It is described that to carry out respiratory movement gate alignment technique concrete steps with the true number of photons gate control method of ring as follows:
A, obtain the data that PET scanning result is list model format; When patient carries out breast abdominal part PET scanography, the result of scanning is exported with list model data;
B, these data are divided into N frame by a Fixed Time Interval; Fixed Time Interval can be chosen 200ms, N=PET sweep time/200ms, and N is positive integer, if being not integer, rounds to zero direction, it is 20s that this embodiment gets PET sweep time, N=PET sweep time/200ms=100 so;
C, in the data of every frame, the true number of photons of ring to the each ring of PET under unit radioactive concentration is added up, M frame I encircles true number of photons=the M frame I and encircles true photon grand total/the M frame radioactive concentration;
Wherein M is in the numbering through having added up the frame that encircles true number of photons, the gauging ring numbering that I is pet scanner, and according to step B, M is 1 to 100 in this embodiment, because the PET equipment of experiment only has 18 rings, so I is 1 to 18;
Fig. 3 is synchronized with the movement and list model data that symmetrical cylinder moves in pet scanner is carried out after true number of photons statistics to two, shows the true number of photons distribution situation of ring of 8 different frames in the period of motion;
D, through having added up in all frames that encircle true number of photons, choose wherein a frame as with reference to frame, compare with the true number of photons of ring that other have added up all frames that encircle true number of photons respectively with this reference frame, draw the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of reference frame; Choose wherein a frame as with reference to frame, the optional wherein any frame added up in all frames that encircle true number of photons of a frame here; Concrete selection the 7th frame is reference frame, compares respectively with the 7th frame with the true number of photons of ring that other have added up all frames that encircle true number of photons, draws the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of the 7th frame:
In formula, M is in the numbering through having added up the frame that encircles true number of photons, I is the gauging ring numbering of pet scanner, DRTCE(M, I) be the true number of photons through having added up the M frame I ring that encircles true number of photons, DRTCE(7, I) for having added up in process the true number of photons of the 7th frame I gauging ring of encircling true number of photons;
In Fig. 3, choosing the 7th frame is reference frame, compares respectively by the true number of photons of ring of the 7th frame with other frame, obtains corresponding absolute error (value in Fig. 3 bracket).
E, a selected threshold value, by the absolute error of the true number of photons of ring of true ring of other frames number of photons and reference frame therewith threshold value compare, all data that meet absolute error and be less than the frame of the threshold value new list model data of formation portion of putting together; When selected threshold value, all absolute error value are analyzed, are fitted to a curve, ask the second dervative of curve, choose make second dervative be zero absolute error value as threshold value, in this embodiment, threshold value is 0.02000;
F, the new list model data obtaining is carried out to three-dimensional reconstruction, so just obtain the width PET image of gate after proofreading and correct clearly;
It is described that to carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring be to utilize PET to encircle the feature that respective change can occur along with the motion of lung true number of photons to carry out the technology that PET respiratory movement gate is proofreaied and correct.
It is described that to carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring be the technology of carrying out the correction of respiratory movement gate by diversity of the distribution of true number of photons in each ring of analyzing and processing PET.
Fig. 4 shown two be synchronized with the movement and symmetrical cylinder emulation respiratory movement gate proofread and correct experiment three-dimensional reconstruction image, wherein static state is classified cylinder actionless three-dimensional reconstruction image in scanning device as, motion blur is classified the three-dimensional reconstruction image of cylinder periodic movement in scanning device as, and gate is classified as and used the present invention to carry out the three-dimensional reconstruction image after respiratory movement correction to the list model data of PET scanning.
In Fig. 4, use the true number of photons gate control method of the present invention's ring to carry out shape, size and the position of the cylinder in the image (coronalplane, sagittal plane) after respiratory movement gate alignment technique, close to shape, size and the position of static Circle in Digital Images cylinder.Result proves to use the true number of photons respiratory movement gate alignment technique of ring can effectively reduce respiratory movement artifact, improves the definition of image, can measure exactly two symmetrical cylindrical actual size and positions.
By reference to the accompanying drawings specific embodiments of the invention are explained in detail above, but the present invention is not limited to above-described embodiment, in the ken possessing those of ordinary skill in the art, can also under the prerequisite that does not depart from aim of the present invention, makes various variations.
Claims (6)
1. carry out a respiratory movement gate alignment technique with the true number of photons gate control method of ring, it is characterized in that: first obtain the data that PET scanning result is list model format; These data are divided into N frame by a Fixed Time Interval; In the data of every frame, the true number of photons of ring to the each ring of PET under unit radioactive concentration is added up; Add up in all frames that encircle true number of photons in process, choose wherein a frame as with reference to frame, compare with the true number of photons of ring that other have added up all frames that encircle true number of photons respectively with this reference frame, draw the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of reference frame; A selected threshold value, by the absolute error of the true number of photons of ring of true ring of other frames number of photons and reference frame therewith threshold value compare, all data that meet absolute error and be less than the frame of the threshold value new list model data of formation portion of putting together; Then the new list model data obtaining is carried out to three-dimensional reconstruction, so just obtain the PET image after width gate correction clearly.
2. according to claim 1ly carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring, it is characterized in that: described to carry out respiratory movement gate alignment technique concrete steps as follows with encircling true number of photons gate control method:
A, obtain the data that PET scanning result is list model format; When patient carries out breast abdominal part PET scanography, the result of scanning is exported with list model data;
B, these data are divided into N frame by a Fixed Time Interval;
C, in the data of every frame, the true number of photons of ring to the each ring of PET under unit radioactive concentration is added up, M frame I encircles true number of photons=the M frame I and encircles true photon grand total/the M frame radioactive concentration;
Wherein M is in the numbering through having added up the frame that encircles true number of photons, the gauging ring numbering that I is pet scanner;
D, through having added up in all frames that encircle true number of photons, choose wherein a frame as with reference to frame, compare with the true number of photons of ring that other have added up all frames that encircle true number of photons respectively with this reference frame, draw the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of reference frame; Choose wherein a frame as with reference to frame, the optional wherein any frame added up in all frames that encircle true number of photons of a frame here;
E, a selected threshold value, by the absolute error of the true number of photons of ring of true ring of other frames number of photons and reference frame therewith threshold value compare, all data that meet absolute error and be less than the frame of the threshold value new list model data of formation portion of putting together; When selected threshold value, all absolute error value are analyzed, fitted to a curve, ask the second dervative of curve, choosing and making second dervative is that zero absolute error value is as threshold value;
F, the new list model data obtaining is carried out to three-dimensional reconstruction, so just obtain the width PET image of gate after proofreading and correct clearly.
According to claim 1 with ring true number of photons gate control method carry out respiratory movement gate alignment technique, it is characterized in that: in described step B, Fixed Time Interval can be chosen 200ms, N=PET sweep time/200ms, N is positive integer, if being not integer, rounds to zero direction.
According to claim 1 with ring true number of photons gate control method carry out respiratory movement gate alignment technique, it is characterized in that: in described step D, concrete selection the 7th frame is reference frame, compare with the true number of photons of ring that other have added up all frames that encircle true number of photons respectively with the 7th frame, draw the absolute error of the true number of photons of ring of other frames and the true number of photons of ring of the 7th frame:
In formula, M is in the numbering through having added up the frame that encircles true number of photons, I is the gauging ring numbering of pet scanner, DRTCE(M, I) be the true number of photons through having added up the M frame I ring that encircles true number of photons, DRTCE(7, I) for having added up in process the true number of photons of the 7th frame I gauging ring of encircling true number of photons.
5. according to claim 1ly carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring, it is characterized in that: described to carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring be to utilize PET to encircle the technology that respective change can occur along with the motion of lung true number of photons feature is carried out the correction of PET respiratory movement gate.
6. according to claim 1ly carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring, it is characterized in that: described to carry out respiratory movement gate alignment technique with the true number of photons gate control method of ring be by the technology that in each ring of analyzing and processing PET, very diversity of the distribution of number of photons is carried out the correction of respiratory movement gate.
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| CN104899867A (en) * | 2015-01-14 | 2015-09-09 | 昆明理工大学 | Automatic determining method for gating threshold in respiratory movement gating correction method |
| CN106618628A (en) * | 2017-01-24 | 2017-05-10 | 昆明理工大学 | Breathing movement gating correction and attenuation correction method based on PET/CT imaging |
| CN107468267A (en) * | 2017-08-11 | 2017-12-15 | 上海联影医疗科技有限公司 | Data processing method and medical imaging devices |
| CN108921777A (en) * | 2018-06-11 | 2018-11-30 | 昆明理工大学 | A kind of respiratory movement gated image method for registering based on the PET-CT detection true number of photons of ring |
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