CN104000633A - Biodegradable lumen closed clamp and manufacturing method thereof - Google Patents
Biodegradable lumen closed clamp and manufacturing method thereof Download PDFInfo
- Publication number
- CN104000633A CN104000633A CN201410253104.3A CN201410253104A CN104000633A CN 104000633 A CN104000633 A CN 104000633A CN 201410253104 A CN201410253104 A CN 201410253104A CN 104000633 A CN104000633 A CN 104000633A
- Authority
- CN
- China
- Prior art keywords
- clamp
- folder
- obliteration
- biodegradable
- lumen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
- A61B17/1227—Spring clips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/127—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing fillers of phosphorus-containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
Abstract
The invention discloses a biodegradable lumen closed clamp and a manufacturing method thereof and belongs to the technical field of biological medicine, in particular to biodegradable medical disposable material for closing and cutting such lumen structures as blood vessels, cystic gall ducts and ureters in operation. The biodegradable lumen closed clamp body is flexible and strip-shaped and can be folded to close; the closed surface of the clamp body is provided with clamp teeth capable of being closed in a staggered mode, a cylinder-shaped slot is formed in the end, a clamp hammer which enters the cylinder-shaped slot is arranged at the other end, and all the parts make up the lumen closed clamp; the lumen closed clamp is manufactured through a free fused deposition modeling technology after mixing degradable material with hydroxyapatite according to a certain proportion. The biodegradable lumen closed clamp has good bio-compatibility and is capable of degrading in the body; the biodegradable lumen closed clamp has protection design and is easy to operate, so that the biodegradable lumen closed clamp is avoided from accidentally injuring a target organ in use, and the closed clamp is easy to clamp firmly; the biodegradable lumen closed clamp belongs to auxiliary operation tools and has broad prospect.
Description
Technical field
The present invention relates to biological medicine technology field, specifically for the luminal structures such as blood vessel, cystic duct, ureter are pressed from both sides to the biodegradable operation medical disposable material that closes cut-out.
Background technology
Along with the development of thoracoscope and laparoscopic instrument, Wicresoft's endoscope-assistant surgery has also obtained development in an all-round way in recent years, and this type of operation is used widely in multiple section office such as thoracic surgery, department of general surgery, department of obstetrics and gynecology, Urology Surgeries.Wicresoft's endoscope-assistant surgery has that wound is little, pain is light, go out insufficiency of blood, short superiority of hospital stays, and the high praise that has therefore not only obtained doctor has also obtained patient's accreditation.Except patients with terminal, Wicresoft's endoscope-assistant surgery will progressively replace traditional operation becomes operating main flow trend.
The development of Wicresoft's endoscope-assistant surgery has benefited from the development of chamber mirror necessary accessories to a great extent, as high-definition camera, nipper, wire twister, vessel sealing device, ultrasound knife etc.Chamber mirror necessary accessories are divided into operating equipment and operation consumptive material.Operation consumptive material is mainly assisted for organize closed with from disconnected, as ligation such as blood vessel, cystic duct, ureters with from disconnected etc.In traditional operation, the closure of this type of luminal structure from disconnected be all by suture ligature carry out later shears from disconnected, although less expensive, extended the operating time, and often need under the assisting of larger otch, complete.In endoscope-assistant surgery, utilize the method for traditional suture ligature more consuming time, effect is imprecise, therefore often need succedaneum to carry out closure and from disconnected.Be directed at present the trunk such as pulmonary artery, pulmonary vein often by straight cuts device (as the ATW45 of Johnson & Johnson 35mm blood vessel cutting closed) complete, thereby but therefore can cause stitching entirely not occur that blood vessel leaks blood because blood vessel is meticulous for little blood vessel, what therefore clinical practice was at present more is titanium folder and hemolok folder.It is firm that Hemolok clamp holds, but it must overlap blood vessel completely and carry out ligation, cause carrying out when ligation is cut off completing for some completely not free blood vessel, it easily easily comes off in ligation process from hemolok pincers simultaneously, therefore also has technically certain defect; At material in essence, be that titanium folder or hemolok folder are all degradable materials not, therefore long-term existence often easily causes seroma, foreign body reaction etc. in body.
Summary of the invention
The invention provides luminal structures such as being applicable to medium and small blood vessel, cystic duct in human body in Wicresoft's endoscope-assistant surgery situation from disconnected, it is firm that it is easy to use, folder closes, can tube chamber be implemented thorough closure and be carried out from disconnected, and can be degradable in vivo, make it in the situation that ensureing short term efficacy, not produce a kind of biodegradable obliteration folder and its manufacture method of side effect at a specified future date.
The technical scheme that the present invention takes::
A kind of degradable obliteration folder, comprises clamp, and its scheme is: clamp is flexible strip shape, can doubling closure; On the closing face of clamp, have the closed latch that can misplace mutually, there is cylindric draw-in groove end, and the other end is the card hammer that enters cylindric draw-in groove, and entirety forms obliteration folder; Described obliteration folder, its entirety is made by degradation material.
A manufacture method for degradable obliteration folder, its scheme is: obliteration folder is made up of degradation material; Described degradation material is polycaprolactone or PPDO, or the derivant of above-mentioned substance; With hydroxyapatite blend utilize the quiet free manufacturing technology of melting to form in proportion; After polycaprolactone, PPDO or derivatives thereof and hydroxyapatite blend by a certain percentage, utilize the quiet free manufacturing technology of melting to form.
The good effect of implementing after the present invention is:
Owing to having used the degradation material of polycaprolactone, PPDO or derivatives thereof, therefore this repair materials is for the good biocompatibility of tissue, and there is suitable degradation speed preferably, in the situation that ensureing enough mechanical strengths, complete vivo degradation; In addition, done the design of protectiveness and easy operating in structure, made it in use avoid occurring that accidental injury target organ closed clamp are easy to enter clamp position, clamping firmly; It is a rising assisted surgery instrument.
Brief description of the drawings
Fig. 1 obliteration folder open mode perspective view,
State perspective view is held together in Fig. 2 obliteration clamping.
Detailed description of the invention
Now the invention will be further described by reference to the accompanying drawings
A kind of degradable obliteration folder, comprises clamp, and its structure is: clamp 1 is flexible strip shape, can doubling closure; On the closing face of clamp, have the closed latch 2 that can misplace mutually, there is cylindric draw-in groove 4 end, and the other end is the card hammer 3 that enters cylindric draw-in groove, and entirety forms obliteration folder 5; Described obliteration folder, its entirety is made by degradation material.
Described cylindric draw-in groove 4, its structure is: have and can insert the top layer cylinder of card hammer 3 and the inner layer cylinder that is greater than top layer cylinder of ining succession forms.
Described card hammer 3, is elastic shape, connects hammer form by neck, and neck length is slightly larger than top layer cylinder thickness, hammers the inwall that is stuck in top layer cylinder for spherical into shape.
The latch 2 that described dislocation is closed, is made up of the convex tooth of cuboid and onesize concavity tooth, and the angle of convex tooth is circular-arc, and the edge, middle part of cuboid is slightly protruding, and described slightly protruding to be that convex tooth and concavity tooth are closed mutually form tight fit.
A kind of manufacture method of degradable obliteration folder: obliteration folder is made up of degradation material; Described degradation material is polycaprolactone or PPDO, or the derivant of above-mentioned substance; With hydroxyapatite blend in proportion, its ratio is percent meter by weight, gets 30 percent hydroxyapatite and 70 percent polycaprolactone or PPDO or derivatives thereof and mixes; The melting of heating; And melted material is utilized to the quiet free manufacturing technology of melting, molding on demand, and cooling, sterilization, dry, collect finished product for subsequent use.
embodiment
By polycaprolactone, PPDO or derivatives thereof and hydroxyapatite, in 30 70 percent and percent percetage by weight ratio blend, melting on Haake torque rheometer.Material use mould after melt blending is carried out to molding.Then used oxirane disinfection for subsequent use.
Select healthy beasle dog, after general intravenous anesthesia, tracheal intubation, mechanical ventilation, closes as target organ presss from both sides from disconnected taking left gastric artery and cystic duct.
Embodiment result:
All beasle dogs are all survived, and hemorrhage and leak again appears in none example.All dogs are followed up a case by regular visits to 1 year, also do not occur during this time hemorrhage and leak, and material is degradable in the time of JIUYUE, residual without any material in body, and react without local inflammation.
Claims (5)
1. a degradable obliteration folder, comprises clamp, it is characterized in that: clamp (1) is flexible strip shape, can doubling closure; On the closing face of clamp, have the closed latch (2) that can misplace mutually, there is cylindric draw-in groove (4) end, and the other end is the card hammer (3) that enters cylindric draw-in groove, and entirety forms obliteration folder (5); Described obliteration folder, its entirety is made by degradation material.
2. the degradable obliteration of one according to claim 1 folder, is characterized in that: described cylindric draw-in groove (4), its structure is: have the top layer cylinder that can insert card hammer (3) and the inner layer cylinder that is greater than top layer cylinder of ining succession to form.
3. the degradable obliteration folder of one according to claim 1, is characterized in that: described card hammer (3) is elastic shape, connects hammer form by neck, and neck length is slightly larger than top layer cylinder thickness, hammers the inwall that is stuck in top layer cylinder for spherical into shape.
4. the degradable obliteration folder of one according to claim 1, it is characterized in that: the latch (2) that described dislocation is closed, formed by the convex tooth of cuboid and onesize concavity tooth, the angle of convex tooth is circular-arc, the edge, middle part of cuboid is slightly protruding, and described slightly protruding to be that convex tooth and concavity tooth are closed mutually form tight fit.
5. a manufacture method for degradable obliteration folder, is characterized in that: obliteration folder is made up of degradation material; Described degradation material is polycaprolactone or PPDO, or the derivant of above-mentioned substance; With hydroxyapatite blend in proportion, its ratio is percent meter by weight, gets 30 percent hydroxyapatite and 70 percent polycaprolactone or PPDO or derivatives thereof and mixes; The melting of heating; And melted material is utilized to the quiet free manufacturing technology of melting, molding on demand, and cooling, sterilization, dry, collect finished product for subsequent use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410253104.3A CN104000633A (en) | 2014-06-10 | 2014-06-10 | Biodegradable lumen closed clamp and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410253104.3A CN104000633A (en) | 2014-06-10 | 2014-06-10 | Biodegradable lumen closed clamp and manufacturing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104000633A true CN104000633A (en) | 2014-08-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410253104.3A Pending CN104000633A (en) | 2014-06-10 | 2014-06-10 | Biodegradable lumen closed clamp and manufacturing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104000633A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173090A (en) * | 2014-09-11 | 2014-12-03 | 天津万和医疗器械有限公司 | Continuous-shot absorbable clips and clip applier with same |
| CN108236482A (en) * | 2016-12-27 | 2018-07-03 | 江苏风和医疗器材股份有限公司 | Hemostatic clamp |
| CN112843323A (en) * | 2021-01-25 | 2021-05-28 | 北京庆龙科技有限公司 | Hydroxyapatite-added polylactic acid ligation clip and preparation method thereof |
Citations (12)
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|---|---|---|---|---|
| US4519392A (en) * | 1982-10-12 | 1985-05-28 | Lingua Robert W | Hemostasing muscle clips for needleless surgery |
| US4602632A (en) * | 1983-12-14 | 1986-07-29 | Richard Jorgensen | Bio absorbable metal hemostatic clip |
| CN2090684U (en) * | 1990-10-29 | 1991-12-18 | 刘燕 | Disposable bag for obstetrical dressing and apparatus |
| US5676676A (en) * | 1995-08-30 | 1997-10-14 | Porter; Wayne | Ligating clip having ramp-shaped vessel-clamping members |
| US5722982A (en) * | 1996-09-26 | 1998-03-03 | University Technology Corporation | Strabismus surgery apparatus and method |
| CN2812847Y (en) * | 2005-08-23 | 2006-09-06 | 谢海龙 | Endoscope absorbable tissure clamp |
| CN1954781A (en) * | 2005-10-25 | 2007-05-02 | 李艳芳 | Absorbable tissue clamp |
| CN101209355A (en) * | 2007-12-25 | 2008-07-02 | 暨南大学 | Preparation of material for bone plate, bone peg and bone block |
| CN102028517A (en) * | 2011-01-21 | 2011-04-27 | 常州市三联星海医疗器械制造有限公司 | Tissue clamp |
| CN102240233A (en) * | 2011-07-11 | 2011-11-16 | 唐华 | Degradable stent for sternum defect repair and manufacturing method thereof |
| CN203506824U (en) * | 2013-10-29 | 2014-04-02 | 杭州铭众生物科技有限公司 | Absorbable ligation clamp |
| CN203885560U (en) * | 2014-06-10 | 2014-10-22 | 唐华 | Degradable lumen closing clamp |
-
2014
- 2014-06-10 CN CN201410253104.3A patent/CN104000633A/en active Pending
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4519392A (en) * | 1982-10-12 | 1985-05-28 | Lingua Robert W | Hemostasing muscle clips for needleless surgery |
| US4602632A (en) * | 1983-12-14 | 1986-07-29 | Richard Jorgensen | Bio absorbable metal hemostatic clip |
| CN2090684U (en) * | 1990-10-29 | 1991-12-18 | 刘燕 | Disposable bag for obstetrical dressing and apparatus |
| US5676676A (en) * | 1995-08-30 | 1997-10-14 | Porter; Wayne | Ligating clip having ramp-shaped vessel-clamping members |
| US5722982A (en) * | 1996-09-26 | 1998-03-03 | University Technology Corporation | Strabismus surgery apparatus and method |
| CN2812847Y (en) * | 2005-08-23 | 2006-09-06 | 谢海龙 | Endoscope absorbable tissure clamp |
| CN1954781A (en) * | 2005-10-25 | 2007-05-02 | 李艳芳 | Absorbable tissue clamp |
| CN101209355A (en) * | 2007-12-25 | 2008-07-02 | 暨南大学 | Preparation of material for bone plate, bone peg and bone block |
| CN102028517A (en) * | 2011-01-21 | 2011-04-27 | 常州市三联星海医疗器械制造有限公司 | Tissue clamp |
| CN102240233A (en) * | 2011-07-11 | 2011-11-16 | 唐华 | Degradable stent for sternum defect repair and manufacturing method thereof |
| CN203506824U (en) * | 2013-10-29 | 2014-04-02 | 杭州铭众生物科技有限公司 | Absorbable ligation clamp |
| CN203885560U (en) * | 2014-06-10 | 2014-10-22 | 唐华 | Degradable lumen closing clamp |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173090A (en) * | 2014-09-11 | 2014-12-03 | 天津万和医疗器械有限公司 | Continuous-shot absorbable clips and clip applier with same |
| CN108236482A (en) * | 2016-12-27 | 2018-07-03 | 江苏风和医疗器材股份有限公司 | Hemostatic clamp |
| CN112843323A (en) * | 2021-01-25 | 2021-05-28 | 北京庆龙科技有限公司 | Hydroxyapatite-added polylactic acid ligation clip and preparation method thereof |
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| PB01 | Publication | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20140827 |