CN104055607A - Artificial lamina - Google Patents

Artificial lamina Download PDF

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Publication number
CN104055607A
CN104055607A CN201310089418.XA CN201310089418A CN104055607A CN 104055607 A CN104055607 A CN 104055607A CN 201310089418 A CN201310089418 A CN 201310089418A CN 104055607 A CN104055607 A CN 104055607A
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CN
China
Prior art keywords
artificial neural
neural plate
curved surfaces
lamina
skeletonization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201310089418.XA
Other languages
Chinese (zh)
Inventor
史建刚
王元
刘青
林腾飞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JIANGYIN RUIKANGJIAN BIOMEDICAL SCIENCE TECHNOLOGY CO LTD
Original Assignee
JIANGYIN RUIKANGJIAN BIOMEDICAL SCIENCE TECHNOLOGY CO LTD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JIANGYIN RUIKANGJIAN BIOMEDICAL SCIENCE TECHNOLOGY CO LTD filed Critical JIANGYIN RUIKANGJIAN BIOMEDICAL SCIENCE TECHNOLOGY CO LTD
Priority to CN201310089418.XA priority Critical patent/CN104055607A/en
Priority to PCT/CN2014/073303 priority patent/WO2014146549A1/en
Publication of CN104055607A publication Critical patent/CN104055607A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006Properties of materials and coating materials
    • A61F2002/30062(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/3011Cross-sections or two-dimensional shapes
    • A61F2002/30159Concave polygonal shapes
    • A61F2002/30172T-shaped
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30756Cartilage endoprostheses
    • A61F2002/30766Scaffolds for cartilage ingrowth and regeneration

Abstract

The invention relates to the technical field of medical equipment, particularly to an artificial lamina made of a biodegradable material. The cross section of the artificial lamina is roughly herringbone and has the axial length, the lamina comprises three concave curved surfaces formed by one surface of the biodegradable material and a cavity which can accommodate bones and is formed by the other surface of the biodegradable material, the three concave curved surfaces comprise two bone-formation curved surfaces and one isolation curved surface, and the isolation curved surface can be roughly attached to surfaces of the lamina and spinous processes. The artificial lamina can be applied to total laminectomy as well as semi-laminectomy and lamina fenestration.

Description

Artificial neural plate
Technical field
The present invention relates to medical instruments field, be specifically related to a kind of for preventing the embedded material of Laminectomy post-operative complication.
Background technology
In canalis spinalis, operation needs to cut vertebral plate conventionally to expose canalis spinalis chamber, and conventional operation method has Laminectomy, hemilaminectomy and vertebral lamina fenestration art.Laminectomy is that whole vertebral plates and spinous process are stung and removed, and hemilaminectomy and vertebral lamina fenestration art be just by vertebral plate Partial Resection, the complete Via Posterior Spinal Approach structures such as spinous process, zygapophysial joints that retained.
Because hemilaminectomy and vertebral lamina fenestration art have retained said structure, one has effectively retained integrity and the stability of Via Posterior Spinal Approach structure, the two provides attachment point for muscular tissue reconstruction, reduces the generation of the symptoms such as patient's Lumbar pain after operation, so it has been widely adopted and has praised highly.
Research shows, row vertebrae plate resection is postoperative, and first after spinal column, column stability is damaged, and causes unstable spine or pseudoarticulation formation, causes patient's Lumbar pain after operation, now mainly by Posterior Bone Graft, merges to avoid clinically.Its two postoperative scars tissue is climbed along substituting vertebral plate and is lacked as locate, and easily forms adhesion, even causes canalis spinalis restenosis with spinal dura mater and nerve root, is to cause performing the operation in canalis spinalis the not good one of the main reasons of long-term postoperative.Therefore, between spinal dura mater and scar tissue, set up one deck bone barrier, rebuild the relatively complete of topography structure simultaneously, recover the stable of Via Posterior Spinal Approach, reduce and stop scar tissue and spinal dura mater, nerve root to form adhesion, artificial neural plate (artificial lamina, AL) arises at the historic moment then.
As a kind of degradable embedded material being placed between spinal dura mater and musculus sacrospinalis, artificial neural plate can effectively be isolated the matsurface of spinal dura mater and musculus sacrospinalis, prevent that fibrous tissue from growing in canalis spinalis, also can prevent the compressing of scar tissue to dural sac and spinal cord and nerve roots simultaneously.Meanwhile; artificial neural plate can also be take himself as support; induction area of new bone is grown along it; realizing the new osteoplastic while, it is degraded gradually; finally by autologous area of new bone, substituted; and then repair vertebral plate and form canalis spinalis protection spinal cord, stablized spinal column, prevent the generation of the complication such as postoperative restenosis.
Chinese utility model patent ZL201220216238.4(Granted publication day: 2012.12.19) disclose a kind of artificial neural plate (referring to Fig. 1), this artificial neural plate is a kind ofly biodegradation material, to consist of, cross section is herringbone and has the structure of axial length, it comprises three inner sunken faces and a tract consisting of another face of described biodegradation material that a face by described biodegradation material forms, in tract, can hold aggregate.A face (isolation curved surface) in above-mentioned three inner sunken faces can be kept apart spinal dura mater and musculus sacrospinalis, and two other inner sunken face (skeletonization curved surface) interconnects, and can induce area of new bone to grow along it.In use; the isolation curved surface of this artificial neural plate is covered in to the defect of vertebral plate; form closed space with protection dural sac and spinal cord with structure after remaining spinal column; the deposition that two other skeletonization curved surface can be area of new bone cell provides good support, makes the area of new bone can be according to the set shape Fast Growth of this artificial neural plate.
Because hemilaminectomy and vertebral lamina fenestration art have all retained spinous process, be subject to the obstruct of spinous process, make the isolation curved surface of above-mentioned artificial neural plate can not directly be covered in the vertebral plate defect of above-mentioned two kinds of operations, can not be for hemilaminectomy and vertebral lamina fenestration art so it can only be applied to Laminectomy.
Summary of the invention
The object of the invention is can only can not be for the deficiency of hemilaminectomy and vertebral lamina fenestration art for Laminectomy in order to make up artificial neural plate of the prior art, provide a kind of and can be applied to Laminectomy, also can be applied to the artificial neural plate of hemilaminectomy and vertebral lamina fenestration art.
Specifically, artificial neural plate of the present invention is a kind of artificial neural plate consisting of biodegradation material, its cross section is roughly herringbone and has axial length, the tract of three inner sunken faces that this vertebral plate comprises that a face by described biodegradation material forms and the held aggregate that formed by another face of described biodegradation material, described three inner sunken faces comprise two skeletonization curved surfaces and an isolation curved surface, and described isolation curved surface can roughly be fitted with the surface of vertebral plate and spinous process.
In a preference, described biodegradation material is provided with hole.
In another preference, described two skeletonization curved surfaces are not connected mutually, and the described tract that holds aggregate is divided into independent, mutual disconnected two parts separately.
In another preference, described two skeletonization curved surfaces are symmetrical.
In another preference, described biodegradation material is the absorbable macromolecule material.
In another preference, described the absorbable macromolecule material is selected from polylactic acid, polyglycolic acid, polycaprolactone, poly butyric ester, poly-anhydride or its copolymer.
The details of various aspects of the present invention will be able to detailed description in chapters and sections subsequently.By below and the description of claim, feature of the present invention, object and advantage will be more obvious.
Accompanying drawing explanation
Fig. 1 is the structural representation of artificial neural plate of the prior art;
Fig. 2 normal human lumbar vertebra sectional view;
Fig. 3 is the structural representation of the artificial neural plate of embodiment 1;
Fig. 4 is that the artificial neural plate of embodiment 1 adds the schematic diagram after aggregate;
Fig. 5 is the use schematic diagram that the artificial neural plate of embodiment 1 is applied to vertebral lamina fenestration art.
Fig. 6 is the structural representation of the artificial neural plate of embodiment 2;
Fig. 7 is the use schematic diagram that the artificial neural plate of embodiment 2 is applied to Laminectomy.
Reference numeral:
Inner sunken face 1, inner sunken face 2, inner sunken face 3, cavity 4, aggregate 5, hole 6, spinous process 7, vertebral plate 8, taper hole 9, vertebral body 10.
The specific embodiment
As used in the present invention, biodegradated polymer materal be a kind of under the effect of enzyme degradable green ecological macromolecular material, this material is at implant into body and through after a period of time, can by human body, be decomposed and absorb gradually.The biodegradated polymer materal that organizational project is used, according to its source, can be divided into natural polymer and synthetic polymer two classes.
1. natural biological degradable high polymer material
Natural biological degradation material refers to and derives from naturally occurring biodegradable macromole in animals and plants or human body.Natural biological degradable high polymer material is the medical material that the mankind use the earliest, has good biocompatibility and catabolite nontoxic.Typical natural biological degradation material has chitin, chitosan, fibrin, collagen protein and cellulose derivative etc.
2. synthetic class degradable high polymer material
Although Natural Degradation material has some premium properties, but still comes with some shortcomings, as poor in mechanical strength, performance is variant with batch difference.The degradation time of micro structure, mechanical performance, form and the material of synthetic class degradable high polymer material etc. can design in advance and regulate and control, and finally degraded completely, can be avoided the caused untoward reaction of foreign body reaction.Therefore by controlled condition, its production is reproducible, can produce in enormous quantities as required, is most study in tissue engineering material, most widely used timbering material.The more tissue engineering bracket material of application includes but not limited at present: polylactic acid, polyglycolic acid, polycaprolactone, poly butyric ester, poly-anhydride and copolymer thereof etc.
The biodegradation material that can form artificial neural plate of the present invention comprises natural polymer and artificial polymer, be preferably the absorbable macromolecule material, more preferably polylactic acid, polyglycolic acid, polycaprolactone, poly butyric ester, poly-anhydride or its copolymer.
In addition, known to those skilled in the art, the steric configuration of carrier material should be mainly considered in the design of implant, as surface area of the connectivity between the size in hole, hole, material internal etc.Research shows, open-cell material surface should more be conducive to seeking connections with of cell pseudopodium than common material surface, increases the physical force between cellular layer and base material.Perforate on base material is conducive to transportation and the exchange of moisture, inorganic salt and other nutrient substance and products of cellular metabolism, thereby is more conducive to normal growth and the physiological metabolism of cell.So, preferably, on the biodegradation material that forms artificial neural plate of the present invention, can be provided with a plurality of holes, to be more conducive to growth and the deposition of new bone.
The tract of three inner sunken faces that artificial neural plate of the present invention comprises that a face by above-mentioned biodegradation material forms and the held aggregate that formed by another face of above-mentioned biodegradation material, described three inner sunken faces comprise two skeletonization curved surfaces and an isolation curved surface, and described isolation curved surface can roughly be fitted with the surface of vertebral plate and spinous process.Preferably, above-mentioned two skeletonization curved surfaces of artificial neural plate of the present invention can not be connected mutually, and then the above-mentioned tract that holds aggregate is divided into independent, mutual disconnected two parts separately.More preferably, above-mentioned two skeletonization curved surfaces can be symmetrical.
Artificial neural plate of the present invention has following beneficial effect: owing to roughly fitting in the surface of its isolation curved surface and vertebral plate and spinous process, artificial neural plate of the present invention can be covered on vertebral plate and spinous process, the spinal dura mater and the musculus sacrospinalis matsurface that are exposed to vertebral plate SOL place are kept apart, thereby make it can be applied to hemilaminectomy and vertebral lamina fenestration art, made up the deficiencies in the prior art.In addition, when implementing Laminectomy, artificial neural plate of the present invention can be covered on the spinous process and vertebral plate of neighbouring sections of laminectomy sections, and sew up fixing, thereby can significantly promote the reliability that this artificial neural plate is implanted.
Meanwhile, two skeletonization curved surfaces of artificial neural plate of the present invention can be mutually connected, and the doctor that is more convenient for adds aggregate in its tract, and can arbitrarily control its add aggregate number, compactness etc.
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment are only not used in and limit the scope of the invention for the present invention is described.The experimental technique of unreceipted actual conditions in the following example, conventionally according to normal condition or the condition of advising according to manufacturer.
Unless otherwise defined, the same meaning that all specialties of using in literary composition and scientific words and those skilled in the art are familiar.In addition, any method similar or impartial to described content and material all can be applicable in the inventive method.The use that better implementation method described in literary composition and material only present a demonstration.
The above-mentioned feature that the present invention mentions, or the feature that embodiment mentions can combination in any.All features that present patent application description discloses can with any composition forms use, each feature disclosing in description, can anyly provide the alternative characteristics of identical, impartial or similar object to replace.Therefore apart from special instruction, the feature disclosing is only the general example of equalization or similar features.
Embodiment 1
The structure of the artificial neural plate of the present embodiment and use schematic diagram are shown in Fig. 3, Fig. 4 and Fig. 5.As shown in Figure 3, the cross section of this artificial neural plate is roughly herringbone and has axial length, it comprises three inner sunken faces (inner sunken face 1 consisting of as a face of polycaprolactone etc. biodegradation material, inner sunken face 2 and inner sunken face 3) and the tract 4 of the held aggregate that formed by another face of described biodegradation material, above-mentioned three inner sunken faces comprise two skeletonization curved surfaces (inner sunken face 1 and inner sunken face 2) and an isolation curved surface (inner sunken face 3), described isolation curved surface (inner sunken face 3) can roughly be fitted with the surface of vertebral plate and spinous process, so can be covered on vertebral plate and spinous process, also can be covered in laminectomy wound surface.
Fig. 4 and Fig. 5 are the using state schematic diagram of the artificial neural plate of the present embodiment.As shown in Figure 4, in the tract 4 of the artificial neural plate of the present embodiment, can insert aggregate 5, the source of aggregate 5 can be homogeneous allogenic bone or autologous bone.As shown in Figure 5, the isolation curved surface of the artificial neural plate of the present embodiment (inner sunken face 3) is covered on spinous process 7 and vertebral plate 8, thereby keeps apart being exposed to window spinal dura mater and the musculus sacrospinalis at position of vertebral plate 8; The deposition that two skeletonization curved surfaces (inner sunken face 1 and inner sunken face 2) can be area of new bone cell provides good support, makes the area of new bone can be according to the set shape Fast Growth of the artificial neural plate of the present embodiment.And then repair vertebral plate and form canalis spinalis protection spinal cord.
Embodiment 2
The artificial neural plate of the present embodiment is the further improvement of doing on the basis of the artificial neural plate of embodiment 1, as shown in Figure 6, the one, on biodegradation material, be provided with a plurality of apertures 6, to be conducive to the metabolism and growth of new osteocyte, promote its deposition; The 2nd, make originally connected two skeletonization curved surfaces (inner sunken face 1 and inner sunken face 2) separated, and then the tract 4 that can hold aggregate 5 is divided into independent, mutual disconnected two parts separately, to facilitate doctor to add aggregate 5 in tract 4, and can arbitrarily control its quantity of adding aggregate 5, compactness etc.
After adding Wangue material 5, doctor just can sew up two skeletonization curved surfaces of the artificial neural plate of the present embodiment (inner sunken face 1 and inner sunken face 2) and isolation curved surface (inner sunken face 3), to be conducive to the growth of new bone.
As shown in Figure 7, the artificial neural plate of the present embodiment also can be applicable to Laminectomy, and its isolation curved surface can be covered in laminectomy wound surface.
Many aspects involved in the present invention have been done as above and have been set forth.Yet, it should be understood that before not departing from spirit of the present invention and put, those skilled in the art can be equal to and change and modify it, and described change and modification fall into the coverage of the application's claims equally.

Claims (6)

1. the artificial neural plate being formed by biodegradation material, its cross section is roughly herringbone and has axial length, the tract of three inner sunken faces that this vertebral plate comprises that a face by described biodegradation material forms and the held aggregate that formed by another face of described biodegradation material, described three inner sunken faces comprise two skeletonization curved surfaces and an isolation curved surface, it is characterized in that, described isolation curved surface can roughly be fitted with the surface of vertebral plate and spinous process.
2. artificial neural plate according to claim 1, is characterized in that, described biodegradation material is provided with hole.
3. artificial neural plate according to claim 1, is characterized in that, described two skeletonization curved surfaces are not connected mutually, and the described tract that holds aggregate is divided into independent, mutual disconnected two parts separately.
4. artificial neural plate according to claim 3, is characterized in that, described two skeletonization curved surfaces are symmetrical.
5. according to the artificial neural plate described in above-mentioned arbitrary claim, it is characterized in that, described biodegradation material is the absorbable macromolecule material.
6. artificial neural plate according to claim 5, is characterized in that, described the absorbable macromolecule material is selected from polylactic acid, polyglycolic acid, polycaprolactone, poly butyric ester, poly-anhydride or its copolymer.
CN201310089418.XA 2013-03-20 2013-03-20 Artificial lamina Pending CN104055607A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201310089418.XA CN104055607A (en) 2013-03-20 2013-03-20 Artificial lamina
PCT/CN2014/073303 WO2014146549A1 (en) 2013-03-20 2014-03-12 Artificial lamina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310089418.XA CN104055607A (en) 2013-03-20 2013-03-20 Artificial lamina

Publications (1)

Publication Number Publication Date
CN104055607A true CN104055607A (en) 2014-09-24

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Country Status (2)

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WO (1) WO2014146549A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104873257A (en) * 2015-06-05 2015-09-02 兰州大学第一医院 Spinous fixator

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CN2315922Y (en) * 1997-12-29 1999-04-28 汤继文 Artificial bone vertebral lamina
US20010005795A1 (en) * 1999-09-13 2001-06-28 Medtronic, Inc. Lamina prosthesis for delivery of medical treatment
US20060036324A1 (en) * 2004-08-03 2006-02-16 Dan Sachs Adjustable spinal implant device and method
CN2880012Y (en) * 2006-03-14 2007-03-21 杭州市萧山区中医院 Artificial vertebral lamina
CN101327153A (en) * 2007-06-19 2008-12-24 上海交通大学附属第六人民医院 Thoracic and lumbar vertebral posterior prosthesis
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US20110035008A1 (en) * 2005-05-03 2011-02-10 Williams Lytton A Bone anchored surgical mesh
US20110125269A1 (en) * 2009-11-25 2011-05-26 Moskowitz Nathan C Total artificial spino-laminar prosthetic replacement
CN102366335A (en) * 2011-10-27 2012-03-07 黄海燕 Artificial titanium alloy stabilizing-wing vertebral plate for three-dimensional reconstruction shaping of vertebrae
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CN202605057U (en) * 2012-05-14 2012-12-19 中国人民解放军第二军医大学 Artificial vertebral lamina
CN203138749U (en) * 2013-03-20 2013-08-21 上海琳达旺医疗器械有限公司 Artificial vertebral plate

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Publication number Priority date Publication date Assignee Title
CN2315922Y (en) * 1997-12-29 1999-04-28 汤继文 Artificial bone vertebral lamina
US20010005795A1 (en) * 1999-09-13 2001-06-28 Medtronic, Inc. Lamina prosthesis for delivery of medical treatment
US20060036324A1 (en) * 2004-08-03 2006-02-16 Dan Sachs Adjustable spinal implant device and method
US20110035008A1 (en) * 2005-05-03 2011-02-10 Williams Lytton A Bone anchored surgical mesh
CN2880012Y (en) * 2006-03-14 2007-03-21 杭州市萧山区中医院 Artificial vertebral lamina
CN101327153A (en) * 2007-06-19 2008-12-24 上海交通大学附属第六人民医院 Thoracic and lumbar vertebral posterior prosthesis
US20110125269A1 (en) * 2009-11-25 2011-05-26 Moskowitz Nathan C Total artificial spino-laminar prosthetic replacement
CN101889915A (en) * 2010-07-27 2010-11-24 中国人民解放军第二军医大学 Artificial neural plate
CN102366335A (en) * 2011-10-27 2012-03-07 黄海燕 Artificial titanium alloy stabilizing-wing vertebral plate for three-dimensional reconstruction shaping of vertebrae
CN102551923A (en) * 2011-11-11 2012-07-11 康学文 Artificial vertebral plate
CN202605057U (en) * 2012-05-14 2012-12-19 中国人民解放军第二军医大学 Artificial vertebral lamina
CN203138749U (en) * 2013-03-20 2013-08-21 上海琳达旺医疗器械有限公司 Artificial vertebral plate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104873257A (en) * 2015-06-05 2015-09-02 兰州大学第一医院 Spinous fixator

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Application publication date: 20140924