CN104056345A - Transdermal drug delivery device - Google Patents
Transdermal drug delivery device Download PDFInfo
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- CN104056345A CN104056345A CN201310095217.0A CN201310095217A CN104056345A CN 104056345 A CN104056345 A CN 104056345A CN 201310095217 A CN201310095217 A CN 201310095217A CN 104056345 A CN104056345 A CN 104056345A
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- Prior art keywords
- ring cavity
- annular
- wall
- face
- communicated
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
- A61M1/92—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing with liquid supply means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
- A61M1/94—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing with gas supply means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/84—Drainage tubes; Aspiration tips
- A61M1/85—Drainage tubes; Aspiration tips with gas or fluid supply means, e.g. for supplying rinsing fluids or anticoagulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M2005/1586—Holding accessories for holding infusion needles on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Abstract
The invention provides a transdermal drug delivery device and solves the problems that the adsorption force of an outer ring cavity generated by negative pressure is weakened and an adhesion disk is easy to disengage in the prior art. The transdermal drug delivery device comprises a first top surface, an annular outer wall, an annular inner wall, a first connecting pipe and a central ring cavity, wherein the annular outer wall and the annular inner wall are arranged on two sides of the first top surface and are fixedly connected with one side surface of the first top surface; the first top surface, the annular outer wall and the annular inner wall form a first ring cavity; one end of the first connecting pipe is communicated with the first ring cavity, and the other end of the first connecting pipe is communicated with a negative pressure source; the central ring cavity is used for placing drugs and comprises a first annular wall and a second top surface; the first annular wall is connected with one end of the annular inner wall through a first annular bottom surface; the annular inner wall, the first annular bottom surface and the first annular wall form a first annular groove of which an opening is formed in the direction of the first top surface. The transdermal drug delivery device adapts to the curvature change through the opening and closing of the upper end of the first annular groove, so that the first ring cavity is prevented from being restrained by the second top surface, and after being adhered to an uneven part, the adhesion disk is difficult to disengage.
Description
Technical field
The present invention relates to medical apparatus field, refer to especially a kind of transdermal delivery device.
Background technology
Chinese invention patent CN99126047.3, on open day July 18 calendar year 2001, invention and created name is transdermal medication apparatus, by applying ointment or plaster in the dish of applying ointment or plaster of skin surface penetrates to the skin medicine pressurization, performance therapeutical effect.The dish of applying ointment or plaster during treatment is seated on skin, because outer ring cavity communicates with negative pressure source, the skin that outer ring cavity is produced under absorption affinity by negative pressure lifts, the dish that makes to apply ointment or plaster is adsorbed on skin, make central chamber be sealed completely, the volatilization composition that is arranged in the medicine of central chamber can not escape into external environment condition simultaneously.The dish of finding to apply ointment or plaster in actual application exists in some cases and holds caducous problem:
1, the end face of outer ring cavity and the end face of central chamber are to be closely connected and the same plane or the curved surface that form.Because the dish of applying ointment or plaster has certain thickness, end face has with a certain distance from skin, when the dish of applying ointment or plaster is applied ointment or plaster at the comparatively smooth position of health, can apply ointment or plaster very firmly, but when the dish of applying ointment or plaster is applied ointment or plaster at irregular position, such as collare, shank, arm iso-curvature, during compared with large part, the central chamber end face of the dish of applying ointment or plaster can produce very large holdback force to the outer ring cavity end face being connected, and weaken the absorption affinity that outer ring cavity is produced by negative pressure, the dish that makes to apply ointment or plaster easily comes off, and affects normally carrying out of therapeutic process.
2, in therapeutic process, in central chamber, air themperature is at skin temperature or/and under external heat source heating, temperature progressively raises, and the volatile ingredient in the medicine in it also progressively discharges, and the pressure in central chamber is progressively raise, and has promoted the transdermal penetration of medicine.The pressure increasing also makes central chamber end face be subject to deviating from skin surface direction and outside lifting power, when pressure is larger, can make end face outwardly, the outer ring cavity end face being connected is produced to very large holdback force, weakened the absorption affinity that outer ring cavity is produced by negative pressure, the dish that makes to apply ointment or plaster easily comes off, and affects normally carrying out of therapeutic process.
3,, in this technical scheme, vacuum tube is positioned at outer ring cavity end face.In therapeutic process, when vacuum tube is subject to tractive, when encountering because of carelessness, the power of pullling that vacuum tube is suffered can directly be passed to annular outer wall by outer ring cavity end face, weaken the absorption affinity that outer ring cavity is produced by negative pressure, the dish that makes to apply ointment or plaster easily comes off, and affects normally carrying out of therapeutic process.
Summary of the invention
The present invention proposes a kind of transdermal delivery device, has solved and in prior art, has weakened the absorption affinity that outer ring cavity is produced by negative pressure, and the dish that makes to apply ointment or plaster holds caducous problem.
Technical scheme of the present invention is achieved in that
A transdermal delivery device, comprising:
The first end face, and be arranged on the first end face both sides annular outer wall and the annular inner wall affixed with the first end face one side, the first end face, annular outer wall and annular inner wall form the first ring cavity;
The first connection tube, one end is communicated with the first ring cavity, and the other end is communicated with negative pressure source;
Central authorities' ring cavity, for holding medicine;
Described central ring cavity comprises the first annular wall and the second end face, and the first annular wall is connected with annular inner wall one end by the first annular bottom surface;
Annular inner wall, the first annular bottom surface and the first annular wall form first cannelure of opening in the first end face direction.
Preferably, also comprise: the second annular wall, the 3rd annular wall and the second annular bottom surface; The second annular wall, the 3rd annular wall and the second annular bottom surface form second cannelure of opening in the second end face direction.
Preferably, also comprise: the 4th annular wall and the second connection tube, the 4th annular wall and the second end face form the second ring cavity; The first annular wall, the 4th annular wall and the second end face form central authorities' minute ring cavity; Second connection tube one end is communicated with the second ring cavity, and other end negative pressure source is communicated with.
Preferably, also comprise: joint pin, for supporting the first connection tube, is arranged on the second end face; First connection tube one end is communicated with the first ring cavity through joint pin, and the other end is communicated with negative pressure source.
Preferably, the first connection tube also comprises: negative pressure source linkage section and the first ring cavity linkage section; Negative pressure source linkage section is communicated with the first ring cavity linkage section, and first ring cavity linkage section one end is communicated with the first ring cavity, and the other end is communicated with the second ring cavity with the junction of negative pressure source linkage section.
Preferably, the length of the first ring cavity linkage section is greater than the air line distance under the level of the first ring cavity and the second ring cavity.
Preferably, also comprise: the 3rd annular wall and the 4th annular wall; The 3rd annular wall and the second end face form the 3rd ring cavity; The 4th annular wall and the second end face form chamber, Fourth Ring; And the second ring cavity, the 3rd ring cavity and chamber, Fourth Ring decile are arranged on the second end face.
Preferably, the first connection tube comprises: the second ring cavity linkage section, and one end is communicated with the 3rd ring cavity, and the other end is communicated with negative pressure source section; The 3rd ring cavity linkage section, one end is communicated with chamber, Fourth Ring, and the other end is communicated with negative pressure source section.
Preferably, also comprise: air ring, for preventing that stretched skin is excessive under the effect of negative pressure, make skin damage, be arranged on first ring intracavity.
Preferably, the ventilative air ring of air ring.
The first cannelure that technical solution of the present invention consists of annular inner wall, the first annular bottom surface and the first annular wall, when being attached to the out-of-flatness position that body surface curvature is different (as collare, shank, arm), because the first cannelure is separated the first end face and the second end face, the first cannelure can adapt to by the opening and closing of its upper end the variation of curvature, thereby avoid the second end face to the pining down of the first ring cavity, institute so that docile at out-of-flatness position difficult drop-off;
In addition, by being provided with the second ring cavity, and be communicated with negative pressure source by the second connection tube, can make the second ring cavity be attached on skin, thereby reduce it, because its gas pressure increases, make the outwardly deformation extent of end face, so difficult drop-off;
Moreover, owing to being fixed on by joint pin on the end face of central chamber, when the first connection tube is subject to tractive, first its active force acts on the second end face, and the second end face can be dissolved active force by corresponding strain, avoid it to be directly delivered on the first ring cavity, thereby avoid its absorption affinity that weakens the first ring cavity, so difficult drop-off.When adopting negative pressure source linkage section to be connected with the first ring cavity linkage section, owing to being added in the active force of the first connection tube, be applied on the second end face, can avoid its absorption affinity that weakens the first ring cavity, so difficult drop-off.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, to the accompanying drawing of required use in embodiment or description of the Prior Art be briefly described below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skills, do not paying under the prerequisite of creative work, can also obtain according to these accompanying drawings other accompanying drawing.
Fig. 1 is the structural representation of an embodiment of a kind of transdermal delivery device of the present invention;
Fig. 2 is the structural representation of a kind of another embodiment of transdermal delivery device of the present invention;
Fig. 3 is the structural representation of a kind of another embodiment of transdermal delivery device of the present invention;
Fig. 4 is the structural representation of a kind of another embodiment of transdermal delivery device of the present invention;
Fig. 5 is the structural representation of a kind of another embodiment of transdermal delivery device of the present invention;
Fig. 6 is the structural representation of a kind of another embodiment of transdermal delivery device of the present invention;
Fig. 7 is the structural representation of an embodiment of central ring cavity in a kind of transdermal delivery device of the present invention.
In figure:
1, the first end face; 2, annular outer wall; 3, annular inner wall; 4, the first ring cavity; 5, the first connection tube; 6, central ring cavity; 7, the first annular wall; 8, the second end face; 9, the first annular bottom surface; 10, the first cannelure; 11, the 4th annular wall; 12, the second connection tube; 13, the second ring cavity; 14, central authorities' minute ring cavity; 15, joint pin; 16, negative pressure source linkage section; 17, the first ring cavity linkage section; 18, the 3rd ring cavity; 19, chamber, Fourth Ring; 20, skin; 21, the second annular wall; 22, the 3rd annular wall; 23, the second annular bottom surface; 24, the second cannelure; 25, air ring.
The specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is only the present invention's part embodiment, rather than whole embodiment.Embodiment based in the present invention, those of ordinary skills, not making the every other embodiment obtaining under creative work prerequisite, belong to the scope of protection of the invention.
As shown in Fig. 1-7, a kind of transdermal delivery device of the present invention, comprising:
The first end face 1, and be arranged on the first end face 1 both sides annular outer wall 2 and annular inner wall 3, the first end faces 1, annular outer wall 2 and annular inner wall 3 composition first ring cavities 4 affixed with the first end face 1 one sides;
The first connection tube 5, one end is communicated with the first ring cavity 4, and the other end is communicated with negative pressure source;
Central authorities' ring cavity 6, for holding medicine;
Described central ring cavity (6) comprises the first annular wall 7 and the second end face 8, and the first annular wall 7 is connected with annular inner wall 3 one end by the first annular bottom surface 9;
Annular inner wall 3, the first annular bottom surface 9 and the first annular wall 7 form first cannelure 10 of opening in the first end face 1 direction.
The first cannelure 10 forming by annular inner wall 3, the first annular bottom surface 9 and the first annular wall 7, when being attached to the out-of-flatness position that body surface curvature is different (as collare, shank, arm), because the first cannelure 10 is separated the first end face 1 and the second end face 8, the first cannelure 10 can adapt to by the opening and closing of its upper end the variation of curvature, thereby avoid pining down of 8 pairs of the first ring cavities 4 of the second end face, institute so that docile at out-of-flatness position difficult drop-off.
In one embodiment of the present of invention, the first ring cavity 4 forming by the first end face 1, annular outer wall 2 and annular inner wall 3, wherein, first connection tube 5 one end are communicated with the first ring cavity 4, the other end is communicated with negative pressure source, the central ring cavity 6 forming by the first annular wall 7 and the second end face 8, and the first annular wall 7 is connected with first annular bottom surface 9 one end, one end of the first annular bottom surface 9 is connected with annular inner wall 3, and then annular inner wall 3, the first annular bottom surface 9 and the first annular wall 7 form the first cannelure 10, in operational phase, the first ring cavity 4 and central ring cavity 6 are applied ointment or plaster on skin 20, and medicine is placed in central ring cavity 6, negative pressure source produces absorption affinity and by the first connection tube 5, skin 20 is lifted, the first ring cavity 4 is adsorbed on skin 20, make central ring cavity 6 be sealed completely simultaneously, after making to be arranged in the drug volatilization of central ring cavity 6, can not escape into external environment condition, and when applying ointment or plaster at out-of-flatness position, the opening of the first cannelure 10 opens, spacing increases, to adapt to the variation of the out-of-flatness position rate of curving, so just avoided pining down of 8 pairs of the first end faces 1 of the second end face, avoid weakening the absorption affinity of the first ring cavity 4, make difficult drop-off.
As shown in Figure 5, in an alternative embodiment of the invention, preferred, also comprise: the second annular wall 21, the 3rd annular wall 22 and the second annular bottom surface 23; The second annular wall 21, the 3rd annular wall 22 and the second annular bottom surface 23 form second cannelure 24 of opening in the second end face 8 directions.
The second annular wall 21 is connected with second annular bottom surface 23 one end, the 3rd annular wall 22 is connected with the other end of the second annular bottom surface 23, by the second annular wall 21, the second annular bottom surface 23 and the 3rd annular wall 22, form the second cannelure 24, when applying ointment or plaster at the larger position of degree of crook, the second cannelure 24 coordinates the first cannelure 10, both see mouthful that end all dehisces, to use degree of crook compared with the rate of curving of large part, the absorption affinity of further avoiding weakening the first ring cavity 4 by such design, makes difficult drop-off.
As shown in Figure 2, in another embodiment of this reality invention, preferred, also comprise: the 4th annular wall 11 and the second connection tube 12, the four annular wall 11 and the second end face 8 form the second ring cavity 13; The first annular wall 7, the 4th annular wall 11 and the second end face 8 form central authorities' minute ring cavity 14; Second connection tube 12 one end are communicated with the second ring cavity 13, and other end negative pressure source is communicated with.
The second ring cavity 13 that the 4th annular wall 11 and the second end face 8 form, and the second ring cavity 13 is communicated with negative pressure source by the second connection tube 12, by the second ring cavity 13, central ring cavity 6 is divided into central authorities' minute ring cavity 14, in the present embodiment, the second connection tube 12 can be communicated with negative pressure source separately, certainly in the situation that using the first connection tube 5, also the second connection tube 12 can be communicated with the first connection tube 5, by the first connection tube 5, be communicated with negative pressure source again, can save to a certain extent manufacturing cost in this way, concrete condition is determined with actual user demand, in the present invention, this is not further limited, operational phase, under the effect of negative pressure source, by the second connection tube 12, the skin 20 under the second ring cavity 13 is adsorbed, the central part of the second end face 8 has been carried out to grappling, make its projection that can outwards not expand in gas expansion or progressively increase situation of pressure, avoid weakening the absorption affinity of the first ring cavity 4, so difficult drop-off.
As shown in Figure 3, in another embodiment of the present invention, preferred, also comprise: joint pin 15, for supporting the first connection tube 5, is arranged on the second end face 8; First connection tube 5 one end are communicated with the first ring cavity 4 through joint pin 15, and the other end is communicated with negative pressure source.
In the present embodiment, on the second end face 8, set up a joint pin 15 fixed with it, first connection tube 5 one end are passed joint pin 15 and are fixed on this joint pin 15, the first connection tube 5 is communicated with the first ring cavity 4 through one end of joint pin 15, and be greater than the first end face 1 air line distance between central point and the first ring cavity 4 central points when water balance state through the length of the first connection tube 5 of joint pin 15 ends, when the second end face 8 is water flattened state, the first connection tube 5 is crooked, and when applying ointment or plaster at the larger position of health curvature, the length of the first connection tube 5 can adapt to this distance having increased, can the first end face 1 not formed and be pind down, simultaneously, because the first connection tube 5 is fixed on the second end face 8 by joint pin 15, when the first connection tube 5 is subject to tractive, first its active force acts on the second end face 8, and the second end face 8 can be dissolved active force by corresponding strain, avoid it to be directly delivered on the first end face 1, thereby avoid its absorption affinity that weakens the first ring cavity 4, so difficult drop-off.
Preferably, the first connection tube 5 also comprises: negative pressure source linkage section 16 and the first ring cavity linkage section 17; Negative pressure source linkage section 16 is communicated with the first ring cavity linkage section 17, and first ring cavity linkage section 17 one end are communicated with the first ring cavity 4, and the other end is communicated with the second ring cavity 13 with the junction of negative pressure source linkage section 16.
Preferably, the length of the first ring cavity linkage section 17 is greater than the air line distance under the level of the first ring cavity 4 and the second ring cavity 13.
As shown in Figure 4, in an embodiment more of the present invention, the first connection tube 5 comprises negative pressure source linkage section 16 and the first ring cavity linkage section 17, the first ring cavity linkage section 17 is communicated with the first ring cavity 4, the junction of the first ring cavity linkage section 17 and negative pressure source linkage section 16 is communicated with the second ring cavity 13, wherein, the length of the first ring cavity linkage section 17 is greater than the air line distance under the level of the first ring cavity 4 and the second ring cavity 13, when applying ointment or plaster at the larger position of health curvature, the first ring cavity linkage section 17 can have enough length to adapt to the increase of its two ends distance, avoid the first end face 1 to be pind down, simultaneously, under the effect of negative pressure source, by the first connection tube 5, the skin 20 under the second ring cavity 13 is adsorbed, the central part of the second end face 8 has been carried out to grappling, make it at gas expansion, projection can outwards not expand in progressively increase situation of pressure, avoid weakening the absorption affinity of the first ring cavity 4, so difficult drop-off.
Preferably, also comprise: the 3rd annular wall 22 and the 4th annular wall 11; The 3rd annular wall 22 and the second end face 8 form the 3rd ring cavity 18; The 4th annular wall 11 and the second end face 8 form chamber, Fourth Ring 19; And the second ring cavity 13, the 3rd ring cavity 18 and chamber, Fourth Ring 19 deciles are arranged on the second end face 8.
As shown in Figure 7, in another embodiment of the present invention, by the 3rd annular wall 22 and the second end face 8, form the 3rd ring cavity 18, the 4th annular wall 11 and the second end face 8 form chamber, Fourth Ring 19, and the second ring cavity 13, the 3rd ring cavity 18 and chamber, Fourth Ring 19 deciles are arranged on the second end face 8, it is preferred technical scheme that a ring cavity is set in the present invention, for avoiding the second end face 8 projection that can not outwards expand, can arrange 4, 5 or more ring cavity, for this being not construed as limiting in the present embodiment of saving space, in the present embodiment, in the second end face 8, be provided with circular passage by the second ring cavity 13, the 3rd ring cavity 18 and chamber, Fourth Ring 19 are communicated with, by 3 positions, the second end face 8 is carried out to grappling, can more effectively retrain the second end face 8, make its projection that can not outwards expand, and then avoid weakening the absorption affinity of the first ring cavity 4, a difficult drop-off.
In another embodiment of the present invention, preferred, the first connection tube 5 comprises: the second ring cavity linkage section, and one end is communicated with the 3rd ring cavity 18, and the other end is communicated with negative pressure source section; The 3rd ring cavity linkage section, one end is communicated with chamber, Fourth Ring 19, and the other end is communicated with negative pressure source section.
In the present embodiment, by the second ring cavity linkage section and the 3rd ring cavity linkage section, be communicated with the second ring cavity 13 and chamber, Fourth Ring 19 respectively, before administration, under the effect of negative pressure, by 3 positions, the second end face 8 is carried out to grappling, can more effectively retrain the second end face 8, make its projection that can not outwards expand, and then avoid weakening the absorption affinity of the first ring cavity 4, a difficult drop-off.
As shown in Figure 6, in another embodiment of the present invention, preferred, also comprise: air ring 25, for preventing that stretched skin 20 is excessive under the effect of negative pressure, make skin 20 impaired, be arranged in the first ring cavity 4.
Preferably, the ventilative air ring 25 of air ring 25.
Air ring 25 is arranged in the first ring cavity 4, under the effect in negative pressure, skin 20 is stretched, but when being stretched to a certain degree, skin 20 withstands on air ring 25, therefore avoided skin 20 stretching transitions to cause the problem of damage to occur to skin 20, air ring 25 can also be arranged in the second ring cavity 13, and be consolidated with a sidewall or the two side of the first ring cavity 4, also the one side of air ring 25 and the first end face 1 can be consolidated, be about to air ring 25 and the first end face 1 and fit together by viscose etc.; Air ring 25 can also be fixed in the first ring cavity 4 in other way, but for this being repeated no more in the present embodiment of saving space; In the present embodiment, on air ring 25, be specifically as follows the air ring 25 with air-vent, can effectively under the effect of negative pressure source, skin 20 be lifted like this, certainly air ring 25 can also be cotton pad, non-woven fabrics pad etc., all can guarantee under ventilative prerequisite, avoid skin 20 stretching transitions to cause the problem of damage to occur to skin 20.
These are only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. a transdermal delivery device, comprising:
The first end face (1), and being arranged on described the first end face (1) both sides annular outer wall (2) and the annular inner wall (3) affixed with described the first end face (1) one side, described the first end face (1), described annular outer wall (2) and described annular inner wall (3) form the first ring cavity (4);
The first connection tube (5), one end is communicated with described the first ring cavity (4), and the other end is communicated with negative pressure source;
Central authorities' ring cavity (6), for holding medicine;
It is characterized in that,
Described central ring cavity (6) comprises the first annular wall (7) and the second end face (8), and described the first annular wall (7) is connected with described annular inner wall (3) one end by the first annular bottom surface (9);
Described annular inner wall (3), described the first annular bottom surface (9) and described the first annular wall (7) form first cannelure (10) of opening in the first end face (1) direction.
2. transdermal delivery device as claimed in claim 1, is characterized in that, also comprises:
The second annular wall (21), the 3rd annular wall (22) and the second annular bottom surface (23);
Described the second annular wall (21), described the 3rd annular wall (22) and described the second annular bottom surface (23) form second cannelure (24) of opening in the second end face (8) direction.
3. transdermal delivery device as claimed in claim 1, is characterized in that, also comprises:
The 4th annular wall (11) and the second connection tube (12), described the 4th annular wall (11) and described the second end face (8) form the second ring cavity (13);
Described the first annular wall (7), described the 4th annular wall (11) and described the second end face (8) form central authorities' minute ring cavity (14);
Described the second connection tube (12) one end is communicated with described the second ring cavity (13), and other end negative pressure source is communicated with.
4. transdermal delivery device as claimed in claim 1, is characterized in that, also comprises:
Joint pin (15), for supporting described the first connection tube (5), is arranged on described the second end face (8);
Described the first connection tube (5) one end is communicated with described the first ring cavity (4) through described joint pin (15), and the other end is communicated with negative pressure source.
5. transdermal delivery device as claimed in claim 3, is characterized in that, described the first connection tube (5) also comprises:
Negative pressure source linkage section (16) and the first ring cavity linkage section (17);
Described negative pressure source linkage section (16) is communicated with described the first ring cavity linkage section (17), and described first ring cavity linkage section (17) one end is communicated with described the first ring cavity (4), the other end is communicated with described the second ring cavity (13) with the junction of described negative pressure source linkage section (16).
6. transdermal delivery device as claimed in claim 5, is characterized in that, the length of described the first ring cavity linkage section (17) is greater than the air line distance under the level of described the first ring cavity (4) and described the second ring cavity (13).
7. transdermal delivery device as claimed in claim 6, is characterized in that, also comprises:
The 3rd annular wall (22) and the 4th annular wall (11);
Described the 3rd annular wall (22) and described the second end face (8) form the 3rd ring cavity (18); Described the 4th annular wall (11) and described the second end face (8) form chamber, Fourth Ring (19); And described the second ring cavity (13), described the 3rd ring cavity (18) and chamber, described Fourth Ring (19) decile are arranged on described the second end face (8).
8. transdermal delivery device as claimed in claim 7, is characterized in that, described the first connection tube (5) comprising:
The second ring cavity linkage section, one end is communicated with described the 3rd ring cavity (18), and the other end is communicated with described negative pressure source section;
The 3rd ring cavity linkage section, one end is communicated with chamber, described Fourth Ring (19), and the other end is communicated with described negative pressure source section.
9. the transdermal delivery device as described in claim 1 to 8 any one, is characterized in that, also comprises: air ring (25), and excessive for preventing stretched skin under the effect of negative pressure (20), make skin (20) impaired, be arranged in described the first ring cavity (4).
10. transdermal delivery device as claimed in claim 9, is characterized in that, described air ring (25) is specially ventilative air ring (25).
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310095217.0A CN104056345B (en) | 2013-03-22 | 2013-03-22 | Transdermal drug delivery device |
| EP13879016.7A EP2977076B1 (en) | 2013-03-22 | 2013-12-17 | Transdermal administration device |
| JP2015558334A JP6205434B2 (en) | 2013-03-22 | 2013-12-17 | Transdermal drug delivery device |
| US14/655,641 US10052466B2 (en) | 2013-03-22 | 2013-12-17 | Transdermal drug delivering device |
| PCT/CN2013/089618 WO2014146464A1 (en) | 2013-03-22 | 2013-12-17 | Transdermal administration device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310095217.0A CN104056345B (en) | 2013-03-22 | 2013-03-22 | Transdermal drug delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104056345A true CN104056345A (en) | 2014-09-24 |
| CN104056345B CN104056345B (en) | 2017-04-19 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310095217.0A Active CN104056345B (en) | 2013-03-22 | 2013-03-22 | Transdermal drug delivery device |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10052466B2 (en) |
| EP (1) | EP2977076B1 (en) |
| JP (1) | JP6205434B2 (en) |
| CN (1) | CN104056345B (en) |
| WO (1) | WO2014146464A1 (en) |
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- 2013-03-22 CN CN201310095217.0A patent/CN104056345B/en active Active
- 2013-12-17 JP JP2015558334A patent/JP6205434B2/en active Active
- 2013-12-17 EP EP13879016.7A patent/EP2977076B1/en active Active
- 2013-12-17 WO PCT/CN2013/089618 patent/WO2014146464A1/en active Application Filing
- 2013-12-17 US US14/655,641 patent/US10052466B2/en active Active
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| US5358467A (en) * | 1991-05-05 | 1994-10-25 | Anatole Milstein | Method for vacuum mechanothermal stimulation of the body surface |
| CN2242701Y (en) * | 1996-03-08 | 1996-12-18 | 陈刚 | External-use medicine intensified permeating therapeutic instrument |
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| WO2002005890A2 (en) * | 2000-07-14 | 2002-01-24 | Becton, Dickinson And Company | Microdevice and method of manufacturing a microdevice |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2977076A4 (en) | 2016-12-14 |
| JP2016507310A (en) | 2016-03-10 |
| US20150360013A1 (en) | 2015-12-17 |
| CN104056345B (en) | 2017-04-19 |
| WO2014146464A1 (en) | 2014-09-25 |
| JP6205434B2 (en) | 2017-09-27 |
| EP2977076B1 (en) | 2023-08-09 |
| EP2977076A1 (en) | 2016-01-27 |
| US10052466B2 (en) | 2018-08-21 |
| EP2977076C0 (en) | 2023-08-09 |
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