CN104135958B - 用有聚合物消融元件的新消融导管调变神经的装置和方法 - Google Patents

用有聚合物消融元件的新消融导管调变神经的装置和方法 Download PDF

Info

Publication number
CN104135958B
CN104135958B CN201280070846.1A CN201280070846A CN104135958B CN 104135958 B CN104135958 B CN 104135958B CN 201280070846 A CN201280070846 A CN 201280070846A CN 104135958 B CN104135958 B CN 104135958B
Authority
CN
China
Prior art keywords
capsule
blood vessel
catheter
window
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280070846.1A
Other languages
English (en)
Other versions
CN104135958A (zh
Inventor
R.苏布拉马尼亚姆
Z.屯
D.J.霍尔恩
D.萨特梅斯特
J.M.安德森
J.S.林德奎斯特
K.D.哈里森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Boston Scientific Scimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Scimed Inc filed Critical Boston Scientific Scimed Inc
Publication of CN104135958A publication Critical patent/CN104135958A/zh
Application granted granted Critical
Publication of CN104135958B publication Critical patent/CN104135958B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A61B2018/00077—Electrical conductivity high, i.e. electrically conducting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A61B2018/00083—Electrical conductivity low, i.e. electrically insulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00107—Coatings on the energy applicator
    • A61B2018/00136—Coatings on the energy applicator with polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/0016—Energy applicators arranged in a two- or three dimensional array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00166—Multiple lumina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A61B2018/00238—Balloons porous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00404—Blood vessels other than those in or around the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00434—Neural system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00505—Urinary tract
    • A61B2018/00511—Kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1435—Spiral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/147—Electrodes transferring energy by capacitive coupling, i.e. with a dielectricum between electrode and target tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1472—Probes or electrodes therefor for use with liquid electrolyte, e.g. virtual electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2218/00—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2218/001—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body having means for irrigation and/or aspiration of substances to and/or from the surgical site
    • A61B2218/002—Irrigation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Cardiology (AREA)
  • Electromagnetism (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

本公开涉及用于神经调变的血管内导管，其包括：具有近侧端和远侧端的伸长部件；具有内腔和囊壁的囊，囊壁包括RF可穿透区段和不导电区段；设置在囊内且向远侧延伸到最远侧的RF可穿透区段的电极。RF可穿透区段可包括多个RF可穿透窗，各个窗具有的周向尺寸比轴向尺寸更大。血管内系统适于对肾神经进行调变。

Description

用有聚合物消融元件的新消融导管调变神经的装置和方法
与相关申请的交叉引用
本申请在35 U.S.C§119下要求2011年12月28日提交的美国临时申请No.61/580,972、2012年10月3月1日提交的美国临时申请No.61/605,615和2012年10月3月1日提交的美国临时申请No.61/605,624的优先权，它们通过引用而结合在本文中。
技术领域
本发明大体涉及用于进行神经调变(modulation)和/或消融的经皮和血管内装置。
背景技术
某些处理需要临时或永久地中断或修改选定的神经功能。一个示例处理为肾神经消融，其有时用来处理与充血性心脏故障相关的状况。肾会对充血性心脏故障产生交感响应，除了其它作用之外，这会提高水和/或钠的不合需要的滞留。消融一些延伸到肾的神经可减少或消除这个交感功能，这可对应地减少相关联的不合需要的症状。
许多身体组织，诸如神经(包括肾神经)、脑组织、心脏组织和其它身体器官的组织紧邻血管或其它身体腔体，并且因而可通过血管的壁经皮或在血管内接近。在一些情况下，可为合乎需要的是使用射频(RF)电极来消融血管周神经。在其它情况下，周血管神经可通过其它手段消融，包括对血管壁施加热、超声、激光、微波和其它相关能量源。
在涉及诸如肾神经的血管周神经的处理中，采用这样的能量源的处理方法往往将能量施加为大体周向环，以确保神经得到调变。但是，这种处理可导致电极附近的血管壁有热损伤，以及导致其它不合需要的副作用，诸如(但不限于)，血损害、凝结、血管壁被消弱和/或电极的蛋白质结垢。
发明内容
因此合乎需要的是提供一种备选系统和方法，用于进行沿着和围绕血管或其它身体腔体分配消融或调变位点的组织处理，诸如血管内神经调变处理。
本发明的一些实施例涉及一种囊导管，其构造成进行组织调变，诸如神经调变和/或消融。囊导管包括在装置的远侧端处或附近的可膨胀的囊。囊的壁构造成允许诸如RF能量的电在某些位置处通过以及阻止RF能量或电在其它位置处穿过。电极延伸通过囊的内腔，以供应电或RF能量。在使用中，用传导性流体诸如盐水使囊膨胀，并且囊定位在用于处理的期望的位置处。在一些实施例中，囊可在处理位置处沿周向接触壁，诸如血管壁。电极被激活，并且RF能量传递通过传导性流体且通过RF可穿透的位置离开囊，以对组织进行调变或消融。
囊可为多层囊，其具有由RF可穿透材料制成的第一层和由电绝缘材料制成的第二层。RF可穿透材料可例如亲水性聚氨酯，而电绝缘材料可例如为(非亲水性)聚氨酯。允许RF能量透过的位置或窗不包括电绝缘材料。这些RF可穿透材料制成的这些囊壁可由单层RF可穿透材料形成，而囊的其余部分可具有两个层，一个为RF可穿透材料制成，而一个为电绝缘材料制成。
囊导管可包括其它元件，诸如多内腔导管轴。多内腔导管轴可包括引导线内腔和一个或两个流体内腔，以及传导性部件，传导性部件将电极和一个或多个传感器连接到功率和控制系统上。对于包括两个流体内腔的实施例，一个流体内腔可用来将传导性流体引入囊中，而另一个流体内腔可用来从囊排空传导性流体。以这个方式，传导性流体可在囊内循环。在一些实施例中，流体吸入内腔具有流体入口，其在远侧位置处流体地连接到囊中的囊内腔上，并且流体出口内腔具有流体出口，流体出口在较近侧位置处流体地连接到囊中的囊内腔上。
电极可为任何适当的电极部件，并且可例如为带状电极，带状电极螺旋地缠绕在囊内腔内的导管轴周围，并且可由任何适当的材料制成，诸如铂。
一个说明性实施例具有囊，其具有通过囊壁的三个、四个或更多个RF可穿透窗。窗可为圆形、矩圆形、钻石形、蝶形领结形或另一个适当的形状，并且沿纵向和沿周向间隔开。优选地，窗布置成使得接收组织调变或消融处理的处理区域提供期望的覆盖范围。例如，在一些实施例中，窗布置成使得沿纵向沿着囊壁画出的任何线穿过至少一个窗。这种窗布置允许覆盖血管的周边周围，同时仍然容许窗沿纵向间隔开。在其它实施例中，一个或多个窗布置成使得沿纵向沿着囊壁画出的线穿过两个窗的一部分。在其它实施例中，窗的数量和布置使得沿纵向沿着囊壁画出的任何线穿过至少两个窗。
另一个说明性实施例包括沿着囊的长度或沿着囊的长度的一部分的一个或多个螺旋形窗。另一个说明性实施例包括沿周向围绕囊延伸的一个或多个窗。
另一个说明性实施例包括螺旋形囊，其中，囊内腔为螺旋形且包绕在导管轴周围。在这个实施例中，一个或多个窗可定位在囊导管的外直径上且布置成使得沿纵向(即平行于导管轴)沿着囊壁的外直径画出的任何线穿过至少一个窗。在一个说明性实施例中，螺旋形窗沿着螺旋形囊的外直径延伸。
在另一个说明性实施例中，囊的RF可穿透部分比电绝缘部分的柔性更高，并且传导性流体所提供的压力可使窗突出。囊的不同的部分在相对柔性方面的这样的差异可通过材料的选择、硬度的选择、通过改变层的厚度或层的一部分的厚度或通过其它适当的方法来实现。
在另一个说明性实施例中，窗模制成延伸出囊壁超过电绝缘材料。
在一个说明性使用方法中，使用引导线、引导导管或其它传统的手段将根据本发明的实施例的囊导管经皮和/或在血管内插入到处理位置。利用传导性流体来使囊膨胀，并且传导性流体在囊内循环。电极被激活且RF能量从电极传递通过传导性流体和RF可穿透窗而进入期望的处理区域的组织。处理可在预先确定的时间之后或在满足预先确定的条件之后结束。例如，可通过电极测量阻抗，并且处理可在测量到的阻抗有预先确定的变化之后结束。
一些示例实施例的上面的概述不意图描述本发明的各个公开的实施例或每一个实现。
附图说明
在结合附图来考虑各种实施例的以下详细描述时，可更完整地理解本发明，其中：
图1是示出在现场的肾神经调变系统的示意图。
图2是示出肾神经调变系统的远侧端的示意图。
图3是图2的肾神经调变系统的横截面图。
图4是图2的肾神经调变系统的另一个横截面图。
图5是示出在现场的图2的肾神经调变系统的示意图。
图6是肾神经调变系统的示意图。
图7是肾神经调变系统的示意图。
图8是肾神经调变系统的示意图。
图9是肾神经调变系统的示意图。
图10a是肾神经调变系统的示意图。
图10b是图10a的肾神经调变系统的示意图。
图11a-11d是肾神经调变系统的示例囊的外表面的透视图。
虽然本发明可修改成有各种修改和备选形式，但是它们的细节已经以示例的方式显示在图中且将详细描述。但是，应当理解，不意图将本发明的各方面限于描述的特定实施例。相反，意图覆盖落在本发明的精神和范围内的所有修改、等效方案和备选方案。
具体实施方式
以下描述应当参照附图来阅读，其中，相同参考标号在所有图中表示相同的元件。图未必按比例绘制，图不意图限制要求保护的发明的范围。详细描述和图示出要求保护的发明的示例实施例。
所有数量在本文假设为由用语“大约”修饰。由端点所阐述的数字范围包括包含在那个范围内的所有数量(例如、1至5包括1、1.5、2、2.75、3、3.80、4和5)。
如这个说明书和所附权利要求中使用，单数形式“一个”、“一种”和“该”包括复数个参考对象，除非内容清楚地有其它规定。如这个说明书和所附权利要求中使用，用语“或”大体在其包括“和/或”的意义上使用，除非内容清楚地有其它规定。
注意，说明书中对“实施例”、“一些实施例”、“其它实施例”等的参照表示描述的实施例可包括特定特征、结构或特性，但是每个实施例可能不必包括特定特征、结构或特性。此外，这样的短语不必参照同一实施例。另外，当结合实施例描述特定特征、结构或特性时，结合其它实施例来实现这种特征、结构或特性将在本领域技术人员的知识范围内，而不管是否清楚地描述，除非清楚地有相反的陈述。
虽然本文描述的装置和方法关于通过血管壁的肾神经调变来论述，但是构想到是，装置和方法可用于其中期望进行神经调变和/或消融的其它应用中。用语调变表示可改变被影响的神经和其它组织(诸如脑组织或心脏组织)的功能的消融和其它技术。当期望多次消融时，它们可由单个消融装置连续执行。
图1是在现场的说明性肾神经调变系统的示意图。系统10可包括一个或多个传导性元件16，以对肾消融系统提供功率，肾消融系统包括设置在输送鞘14内的肾神经调变装置12，当伸长部件的沿径向扩张的区域(未显示)处于非扩张构造时，输送鞘14可适于可滑动地容纳肾神经调变装置12，其细节可更好地在后续的图中看到。传导性元件16的近侧端可连接到控制和功率元件18上，控制和功率元件18供应必要的电能，以激活一个或多个电极， 线材16的远侧端在肾神经调变装置12的远侧端处或附近附连到电极上。当适当地激活时，电极能够消融组织，如下面所描述。在后面的公开中，用语电极可看作等效于能够消融相邻组织的元件。用于输送鞘14、伸长部件12和能够消融相邻组织的元件的适当的材料在本领域中是已知的，并且在一些实施例中，可包括内润滑材料层和/或外润滑材料层。在一些情况下，返回电极贴片20可设置在腿上，或在患者的身体上的另一个传统的位置处，以完成电路。还可包括近侧毂(未示出)，其具有用于引导线的端口、膨胀内腔和返回内腔。
控制和功率元件18可包括监测元件，其利用沿着肾神经调变装置12安装的传感器以及用于执行期望的过程适当的控制器来监测参数，诸如功率、温度、电压、脉冲大小、阻抗和/或形状和其它适当的参数。在一些实施例中，功率元件18可控制射频(RF)电极。电极可构造成在大约460kHz的频率下运行。构想到时，可使用在例如450-500kHz 的RF范围中的任何期望的频率。另外构想到的是，可如期望的那样使用其它消融装置，例如(但不限于)电阻加热、超声、微波和激光装置，并且这些装置可能需要功率元件18以不同的形式供应功率。
图2示出肾神经调变装置12的远侧部分。肾神经调变装置12包括囊22和电极24。当在使用中，优选对囊填充传导性流体26，诸如盐水，以允许消融能量从电极24传递通过RF辐射可穿透的窗28。其它适当的传导性流体包括高渗溶液、对比溶液和盐水或高渗盐溶液与对比溶液的混合物。传导性流体可通过中心轴34中的流体入口30引入和通过中心轴34中的流体出口32排出。可包括一个或多个传感器50，诸如热电偶，并且其可设置在轴34上、在囊22上或在另一个适当的位置处。
在图3中示出肾神经调变装置12的轴34在囊的近侧的横截面图。轴34可包括引导线内腔36、连接到流体出口30上的内腔38，以及连接到流体入口32上的内腔40。电极24或将功率供应到电极的传导性元件可沿着轴的外表面延伸或可嵌在轴内。电极24在囊的近侧优选是电绝缘的且用来将功率传递到电极的设置在囊中的部分。在图3中示出两个导体42，其可用来供应功率和允许信息从一个或多个传感器50返回。在一些实施例中，可省略引导线内腔和/或一个流体内腔38、40。在一些实施例中，引导线内腔从装置的远侧端延伸到近侧毂。在其它实施例中，引导线内腔可具有近侧开口，其在系统的近侧部分的远侧。在一些实施例中，流体内腔38、40可连接到使流体循环通过囊22的系统上或供应新的流体且收集排出的流体的系统上。可理解，实施例可仅靠单个流体入口内腔和进入囊的单个流体出口起作用。还可理解的是，构想到其它内腔构造。例如，三个内腔可设置在彼此内或可同心。引导线内腔可为最内部内腔且可由流体入口内腔包围，流体入口内腔又可被流体出口内腔包围。在另一个构想到的实施例中，流体入口和流体出口内腔中的仅一个围绕引导线内腔而设置，并且流体入口和流体出口内腔中的另一个与引导线内腔平行地延伸且与引导线内腔间隔开。另一个构想到的实施例缺乏流体出口内腔，并且流体入口内腔围绕引导线内腔或同心地围绕引导线内腔而设置。在另一个构想到的实施例中，引导线内腔被省略，并且系统包括仅流体入口内腔或仅流体入口和出口内腔。
图4中示出轴34在流体出口32的远侧的横截面图。存在引导线内腔36和流体入口内腔36，以及电极24。在当前示出的实施例中，连接到一个或多个传感器50上的导体42不存在于这个横截面图中。可理解到，在具有一个或多个远侧传感器的实施例中，可存在一个或多个导体42，以与它们连接。
在横截面中显示囊22具有第一层44和第二层46。窗28形成于囊22中，由于缺乏第二层46。第一层44优选由RF可穿透材料制成。一种适当的材料为亲水性聚氨酯。其它适当的材料包括其它亲水性聚合物，诸如亲水性皮巴克斯(Pebax)、亲水性尼龙、亲水性聚酯或具有亲水性嵌段的嵌段共聚物。适当的亲水性皮巴克斯级可包括皮巴克斯 MV1074、皮巴克斯MV 1041、皮巴克斯 MP 1878、皮巴克斯 MV-3000和皮巴克斯 MH-1657。在一些实施例中，一种或多种亲水性聚合物(诸如亲水性皮巴克斯)与用于囊中的其它聚合物混合使用，诸如皮巴克斯 6333、皮巴克斯 7033、皮巴克斯 7233、尼龙 12、维斯塔米德(Vestamid) L2101F、格里拉米德(Grilamid) L20和格里拉米德 L25。适当的亲水性聚合物可展现6%至120%的亲水性(或水吸收量百分比)、20%至50%的亲水性或其它适当的范围。第二层46优选由不导电聚合物制成，诸如非亲水性聚氨酯、皮巴克斯、尼龙、聚酯或嵌段聚合物。其它适当的材料包括一定范围的不导电聚合物中的任一种。第一层和第二层的材料可选择成在两个层之间具有良好的粘结特性。例如，囊22可由亲水性皮巴克斯制成的第一层44和常规或非亲水性皮巴克斯制成的第二层46形成。在其它实施例中，适当的粘结层(未示出)可设置在两个层之间。
图5示出在现场的装置12的远侧端。优选地，可获得各种尺寸的装置12，并且选择的尺寸将允许囊22的窗28接触血管48的壁。囊优选略微有柔性，使得具有标称直径4mm的囊可扩张成配合3.5mm和5mm之间的血管。
图5中示出的特定囊可适于用于肾神经调变应用中。肾神经大体沿纵向围绕肾动脉的外部延伸。这表示人们可改变任何特定周向处理的纵向位置，以及实现相同的神经调变作用。因而窗28布置成实现血管的完全周向覆盖，同时沿纵向间隔开。在这个特定情况下，四个窗28各自覆盖血管的不同的90度弧。各个窗可覆盖不止90度弧。例如，窗28可覆盖100或110度弧，以允许窗28有一些交迭覆盖。这个实施例的窗28的数量为四个且形状为大体圆形。可理解，构想到窗的数量和窗的形状的变化。例如，构想到这样的实施例，其包括1、2、3、4、5、6、7、8、9、10个或更多个窗，并且包括圆形、矩圆形、长方形或多边形的窗。此外，具有不同的长度和宽度的窗可定向成使得最大的尺寸平行于纵向轴线，垂直于纵向轴线或相对于纵向轴线处于另一个角度，诸如45度角度。在一些实施例中，各个窗可具有为2:1、3:1或4:1的纵横比，其中主尺寸垂直于囊的纵向轴线。在一些实施例中，窗可具有定制型式，以提供特定处理型式。
电极24可为扁平的带状电极，其由铂、金、不锈钢、钴合金或其它非氧化材料制成。在一些情况下，可使用钛、钽或钨。电极24可沿着囊22的基本整个长度延伸或可仅延伸到最远侧窗28的远侧边缘。电极24可具有大体螺旋形状且可包绕在轴34周围。在一些情况下，电极24可粘结到轴34上。电极24和窗28可布置成使得电极直接在窗28下面延伸。在一些实施例中，电极24可为线材或可为围绕轴34而设置的管状部件。在一些实施例中，可使用多个电极24，并且多个中的各个可在窗28下面固定到轴34上，并且可共用连接到传导性元件16上的公共件。在包括不止一个电极的其它实施例，可单独地控制各个电极。在这样的实施例中，囊可分成不止一个室，并且各个室可包括一个或多个电极。电极可选择成对囊提供特定柔性水平，以增强系统的可操纵性。可理解的是，对于电极24构想到许多变型。
图6示出另一个肾神经调变装置12的远侧部分，除了这里所描述，该肾神经调变装置12类似于图2的装置12。图6的肾神经调变装置12包括之前描述的元件，诸如轴34、多层囊22和电极24。代替图2的实施例中示出的多个窗28，这个实施例具有单个螺旋窗28。螺旋窗28可包绕在囊22周围达至少一个整圈，或2、3、4、5或更多圈，如示出的那样。一些实施例包括两个或更多个螺旋窗28，它们彼此间隔开且以相同的节距绕在囊22周围。
另一个变型示出在图7中，其中，代替图2的实施例中示出的多个囊28，这个实施例具有单个囊28，其沿周向围绕囊22的中间部分延伸。在这个实施例的其它构想到的变型中可包括两个、三个或更多个相同窗28。在一个构想到的变型中，整个囊壁对于RF能量是可穿透。这种实施例可具有包括层44而不具有层46的囊。
图8示出另一个肾神经调变装置12的远侧部分，除了本文所描述，该肾神经调变装置12类似于图2的装置12。图7的肾神经调变装置12包括之前描述的元件，诸如轴34、多层囊22和电极24(未示出)。这个实施例的囊22为螺旋形且包绕在轴34周围。窗28为螺旋形且遵从螺旋的外直径。这个实施例的变型示出在图9中，其中，窗28周期性地沿着螺旋囊22的外直径设置。窗优选布置成提供完全周向覆盖，同时沿纵向间隔开。可如期望的那样改变窗28的数量和形状。
图10a和10b示出另一个肾神经调变装置12的远侧部分，除了本文所描述，该肾神经调变装置12类似于图2的装置12。图10a示出在标称压力下扩张的装置12，并且图10b示出在较高压力下扩张的装置12。较高压力允许窗28扩张超过囊的第二层46的外表面。以这个方式，图10a和10b的装置12的特定尺寸可适于更宽范围的尺寸的血管。可以各种方式制成装置12。参照图4可理解，窗28可比囊22的其它部分更薄。较薄的柔性聚合物(诸如亲水性聚氨酯)层可比囊的其余部分中存在的双层材料更容易扩张。可通过对囊22的第二层46使用柔性较低的材料或通过增加第二层46的厚度来增强这个作用。适当的材料可包括柔性较低的聚氨酯(不同的硬度85A至55D)、尼龙或聚对苯二甲酸乙二醇酯(PET)或任何适当的不导电聚合物。
在图10b的实施例的变型中，囊可模制或热处理成使得窗28成形为在标称压力下为凹形，如这个图中示出。在这种实施例中，窗可在较低的压力下接触血管壁，并且通过应用不同的量的压力，囊将可扩张到不同的直径。
图11a-11d示出囊壁的圆柱形中心部分的透视图(即图示出被切开和摊平的囊壁的圆柱形中心部分，)。这些图的囊壁可容易地结合到本文描述的任何神经调变系统中。囊22包括由于缺乏电绝缘层44而限定的多个窗28。窗布置在囊上，使得它们的最大尺寸沿周向(即沿着圆柱形囊壁的周边)延伸，而它们的最窄尺寸沿轴向(即沿囊22的中心纵向轴线的方向)延伸。窗28布置成使得从圆柱形囊壁的近侧端到圆柱形囊壁的远侧端画出的任何线穿过至少一个囊。
窗可沿周向交迭，同时沿轴向间隔开。如果从圆柱形囊壁的近侧端到圆柱形囊壁的远侧端画出的线穿过两个囊，那两个囊称为沿周向交迭。
周向交迭的程度可根据窗28的周向尺寸、根据囊的周长或根据绝对尺寸表示。例如，两个相邻的窗展示的周向交迭可例如介于0.2和0.8mm之间、介于0.3和0.7mm之间、介于0.4和0.6mm之间、为至少0.3mm、为至少0.4mm或为至少0.5mm，或为两个窗中的一个的周向尺寸的20%至30%、为两个窗中的一个的周向尺寸的24%至26%、为圆柱形囊壁的周向尺寸的5%至15%、为圆柱形囊壁的周向尺寸的6%至7%，或为圆柱形囊壁的周向尺寸的10%至14%。
窗28优选具有比轴向尺寸更大的周向尺寸。例如，窗的轴向尺寸与周向尺寸的比率可大于1.5:1、大于2:1、大于3:1或为一些其它适当的数字。窗具有的轴向尺寸可为1mm、1.25mm、1.5mm、1.75mm、2mm、2.25mm、2.5mm或其它适当的尺寸，并且周向尺寸大于3mm，诸如为3mm、3.5mm、4mm、4.5mm或5mm。窗28的周向尺寸可为圆柱形部分囊壁的周长的20%、25%、30%或其它适当的百分比。
图11a和11b的窗28显示为以大体螺旋方式布置，其中各个相邻的窗沿轴向和沿周向(同时沿周向交迭)相对于之前的窗偏移。可使用足以提供完全的周向覆盖范围的任何数量的窗。在图11a的实施例中，示出了五个窗28。一些实施例可包括3、4、5、6、7、8、9、10个或更多个窗，并且如果如图6中示出的那样螺旋地布置，窗可围绕囊壁延伸不止一圈。将理解，螺旋构造对于提供完全的周向覆盖不是必须的。完全周向覆盖表示窗布置成使得从圆柱形囊壁的近侧端到圆柱形囊壁的远侧端画出的任何线穿过至少一个囊。
图11a的窗示出为椭圆形。图11b-11d示出其它适当的窗形状，诸如矩圆形(图11b)、蝶形领结形(图11c)和钻石(图11d)。
图11c和11d示出其中不止一个窗28沿着同一周边定位成使得窗处于网格型式的囊型式。可想到使窗位于假想网格的各个相交部上，其中网格的线为在圆柱形囊壁上的周向线和从圆柱形囊壁的近侧端延伸到远侧端的螺旋线。网格线可以规则间距或以不规则间距间隔开。网格可包括两根周向线和两根螺旋线，并且因而提供窗所处的四个相交部。网格可包括三根周向线和两根螺旋线，并且因而提供窗所处的六个相交部。网格可包括四根周向线和两根螺旋线，并且因而提供窗所处的八个相交部。网格可包括五根周向线和两根螺旋线，并且因而提供窗所处的十个相交部(如图11c和11d中示出)。网格可包括两根周向线和三根螺旋线，并且因而提供窗所处的六个相交部。网格可包括三根周向线和三根螺旋线，并且因而提供窗所处的九个相交部。网格可包括四根周向线和三根螺旋线，并且因而提供窗所处的十二个相交部。或者网格可包括呈任何规则或不规则型式的任何期望的数量的周向线和螺旋线，只要窗提供完全周向覆盖。可理解的是，通过这种网格型式的窗产生显著周向交迭。因为在窗对应于血管壁上的提供消融处理的位点，所以这种周向交迭有助于确保血管壁的完全周向处理。
具有窗28的多层囊22可根据本文描述的一个方法或另一种适当的方法制造。在一个方法中，使用吹塑技术或其它适当的方法分开来制造囊的第一层44和第二层46。通过激光、冲孔、机械或液压切割元件或其它适当的技术使孔形成于第二层46中。第一层44定位在第二层46的内侧，并且使用热、化学溶剂、粘合剂或其它适当的技术使两个层44、46熔融在一起。在一些情况下，两个层可定位在模具的内侧，以及/或者可在层44的内侧施加压力，以使用热、溶剂或粘合剂来熔融处于扩张位置的两个层。在一些情况下，两个层不直接连结，而是单独地附连到轴34上。
在另一种制造方法中，内层44形成于柔性心轴上。柔性心轴具有与处于扩张位置的内层44的形状相同的形状，但是由不会很好地粘附到内层44的材料上的材料制成，诸如硅。可通过浸渍涂覆、喷涂、吹塑或其它适当的技术使内层44形成在柔性心轴上。在期望有一个或多个窗28的位置将掩模材料应用在内层上。可使用可移除或临时粘合剂来将掩模材料固定到内层上。然后使用非传导性聚合物再次对其上具有内层和掩模材料的柔性心轴进行浸渍涂覆，以形成外层46。在掩模材料的边缘处切割外层，并且移除掩模材料以及在掩模材料上的外层材料，因而形成囊22。最终，从囊22内移除柔性心轴。
图8和图9的实施例的螺旋囊可由囊前体形成，囊前体具有并排的两个内腔。第一内腔为囊内腔而第二内腔配合在轴34上。这个囊前体形成具有上面所论述的窗28的双层囊。然后将笔直的心轴插入第二内腔中，并且使囊前体围绕笔直的心轴扭转，以使第一内腔形成为螺旋形状。第二内腔可碰撞，并且扭转的囊前体热定形成螺旋形状。在一些变型中，扭转的囊前体插入螺旋模具中，并且在螺旋模具中进行热定形，以帮助形成螺旋囊形状。然后从第一内腔移除笔直的心轴，并且然后使螺旋囊22连结到轴上。
在使用中，提供了诸如系统12的肾消融系统。系统可与标准引导导管一起使用，诸如6 弗伦奇(French)引导导管。作为预备步骤的一部分，可对囊且具体而言亲水性或亲和性(techophilic)材料进行水合。可通过将囊浸泡在盐溶液中来实现水合。可进行一分钟、五分钟或其它适当的浸泡。然后，通过使用引导导管和/或引导线，可经皮引入系统12，如在血管内医疗装置领域中传统上进行的那样。例如，可经皮通过股骨动脉引入诸如0.014″直径引导线的引导线，并且使用标准的射线照相技术来将其操纵到肾动脉。在一些实施例中，输送鞘14可在引导线上引入，并且可抽出引导线，并且系统12然后可通过输送鞘引入。在其它实施例中，可在引导线上引入系统12，或可在引导线上引入包括输送鞘14的系统。在涉及输送鞘14的实施例中，系统12可从输送鞘14的远侧端向远侧输送就位，或可向近侧抽出输送鞘，以暴露系统12。传导性流体26通过流体入口内腔40和流体入口30引入囊中。传导性流体使囊扩张到期望的尺寸。可通过监测引入到系统中的传导性流体的体积间接地监测囊的扩张，或可通过射线照相或其它传统的手段来监测囊的扩张。可选地，一旦囊扩张成期望的尺寸，就可通过持续通过流体入口30引入流体，同时通过流体出口32从囊抽出流体来使流体在囊内循环。流体的循环数率可在2和20毫升/分钟之间、在3和15毫升/分钟之间、在5和10毫升/分钟之间或为其它期望的循环速率。囊可保持在期望的压力下或附近，诸如在1和6个大气压之间的压力、在1.5和4个大气压之间的压力、在2.5和3.5个大气压之间的压力或处于其它期望的压力。然后通过将能量供应到电极来激活电极24。可在400-500Hz下且在0.5和1安培之间供应能量。能量通过传导性流体的介质且通过窗28传递到血管壁，以对组织进行调变或消融。囊的第二层46阻止能量在窗28(其缺乏第二层46)处以外传送通过囊壁。可借助于通过电极监测阻抗的变化来监测处理的过程。如期望的那样，可在该过程期间进行其它测量，诸如压力和/或温度测量。传导性流体26的循环可缓解血管48的接触窗28的组织的温度的升高。电极24优选激活达有效的时间长度，诸如1分钟或2分钟。一旦过程在特定位置处完成，可部分地或完全地缩小囊22，并且使其移动到不同的位置，诸如其它肾动脉，并且如期望的那样，可使用传统的输送和重新定位技术在另一个位置处重复该过程。
示例
虽然已经参照附图描述神经调变系统的各种实施例，但是现在将使用权利要求的语言来描述若干实施例。但是，以下示例不意图包括本文描述的特征的每个实施例或组合。
1. 一种血管内导管，包括：
伸长部件，其具有近侧端和远侧端；
囊，其具有内表面和外表面、内腔，内腔由内表面限定且包括至少一个RF辐射可穿透的区段，该至少一个区段从囊的内表面延伸到囊的外表面；以及
设置在囊中的电极。
2. 根据示例1的血管内导管，其中，囊进一步包括至少一个不导电的区段。
3. 根据示例1-2中的任一个的血管内导管，其中，囊包括三个或更多个RF辐射可穿透的区段。
4. 根据示例3的血管内导管，其中，三个或更多个区段沿周向和纵向彼此间隔开。
5. 根据示例3至4中的任一个的血管内导管，其中，囊包括四个RF辐射可穿透的区段。
6. 根据示例1的血管内导管，其中，至少一个区段为螺旋形区段。
7. 根据示例1的血管内导管，其中，至少一个区段为围绕囊的周边延伸的圆柱形区段。
8. 根据示例7的血管内导管，其中，至少一个区段在囊上居中地定位在囊的近侧端和囊的远侧端之间。
9. 根据示例1至2中的任一个的血管内导管，其中，囊具有螺旋形内腔。
10. 根据示例9的血管内导管，其中，至少一个区段为螺旋形且沿着囊的外直径延伸。
11. 根据示例9的血管内系统，其中，囊包括三个或更多个RF辐射可穿透的区段。
12. 根据示例11的血管内系统，其中，三个或更多个区段沿周向和纵向彼此间隔开。
13. 根据示例11至12中的任一个的血管内系统，其中，囊包括四个RF辐射可穿透的区段。
14. 根据示例9至13中的任一个的血管内导管，其中，区段位于螺旋的外直径上。
15. 根据示例2至14中的任一个的血管内导管，其中，至少一个RF可穿透区段包含柔性聚合材料。
16. 根据示例15的血管内导管，其中，不导电区段包含非柔性聚合材料。
17. 根据示例1至16中的任一个的血管内导管，其中，至少一个RF可穿透区段包含亲水性聚合物。
18. 根据示例17的血管内导管，其中，至少一个RF可穿透区段包含亲水性聚氨酯。
19. 根据示例1至18中的任一个的导管，其中，至少一个RF可穿透区段包含选自下者组成的组的亲水性聚合物：亲水性皮巴克斯、亲水性尼龙、亲水性聚酯或具有亲水性嵌段的嵌段共聚物、皮巴克斯 MV1074、皮巴克斯 MV 1041、皮巴克斯 MP 1878、皮巴克斯 MV-3000、皮巴克斯 MH-1657。
20. 根据示例17至19中的任一个的导管，其中，至少一个RF可穿透区段包含混合有第二聚合物的亲水性聚合物。
21. 根据示例20的导管，其中，第二聚合物选自下者组成的组：皮巴克斯 6333、皮巴克斯 7033、皮巴克斯 7233、尼龙 12、维斯塔米德 L2101F、格里拉米德 L20和格里拉米德 L25。
22. 根据示例17至21中的任一个的导管，其中，亲水性聚合物具有20%至50%的亲水性。
23. 根据示例2至22中的任一个的导管，其中，不导电区段包含非亲水性聚合物。
24. 根据示例2至23中的任一个的血管内导管，其中，不导电区段包含非亲水性聚氨酯。
25. 根据示例1至24中的任一个的血管内导管，其中，囊包括第一层和第二层。
26. 根据示例25的血管内导管，其中，第一层对于RF辐射是可穿透的，而第二层为不导电的。
27. 根据示例25至26中的任一个的血管内导管，其中，第一层在第二层的内侧。
28. 根据示例25至27中的任一个的血管内导管，其中，至少一个RF辐射可穿透的区段不包括第二层。
29. 根据示例25至28中的任一个的血管内导管，其中，至少一个RF辐射可穿透的区段基本由第一层构成。
30. 根据示例25至29中的任一个的血管内导管，其中，在至少一个RF辐射可穿透的区段处，第一层限定囊的外表面。
31. 根据示例25的血管内导管，其中，第一层对于RF辐射是可穿透的而第二层不导电，其中，第一层大体在第二层的内侧，其中，在至少一个RF辐射可穿透的区段处，第一层限定囊的外表面，并且其中，在至少一个RF辐射可穿透的区段处，第一层沿径向延伸超过第二层。
32. 根据示例31的血管内导管，其中，至少一个RF辐射可穿透的区段包括多个凸形窗。
33. 根据示例1至32中的任一个的血管内导管，其中，电极在至少一个可穿透RF的区段下面延伸。
34. 根据示例1至32中的任一个的血管内导管，其中，电极延伸囊的长度的至少80%。
35. 根据示例1至34中的任一个的血管内导管，其中，电极为螺旋形。
36. 根据示例1至35中的任一个的血管内导管，其中，伸长部件延伸囊的长度。
37. 根据示例36的血管内导管，其中，电极设置在伸长部件的外表面上。
38. 根据示例36至37中的任一个的血管内导管，其中，伸长部件包括具有开口远侧端的引导线内腔。
39. 根据示例36至38中的任一个的血管内导管，其中，伸长部件进一步包括流体供应内腔，其具有流体地连接到囊内腔的开口。
40. 根据示例39的血管内导管，其中，伸长部件进一步包括流体返回内腔，其具有流体地连接到轴的开口。
41. 根据示例40的血管内导管，其中，流体供应内腔的开口在流体返回内腔的开口的远侧。
42. 根据示例41的血管内导管，其中，流体供应内腔的开口在囊的远侧腰部中。
43. 根据示例42的血管内导管，其中，流体返回内腔的开口在囊的近侧腰部中。
44. 根据示例1至43中的任一个的血管内导管，进一步包括温度传感器。
45. 根据示例44的血管内导管，其中，温度传感器设置在伸长部件上。
46. 根据示例44的血管内导管，其中，温度传感器设置在囊上。
47. 一种血管内导管，包括：
伸长部件，其具有近侧端和远侧端；
囊，其具有内腔和囊壁，囊壁包括通过不导电囊壁的一个或多个RF可穿透窗，一个或多个RF可穿透窗不透流体流；
电极，其设置在囊内且向远侧延伸到最远侧的RF可穿透区段。
48. 根据示例47的血管内导管，其中，电极为螺旋形。
49. 根据示例47至48中的任一个的血管内导管，其中，伸长部件延伸通过囊。
50. 根据示例49的血管内导管，进一步包括流体地连接到囊内腔的流体供应内腔和流体返回内腔。
51. 一种血管内导管，包括：
伸长部件，其具有近侧端和远侧端；
囊，其具有内表面、外表面、由内表面限定的内腔和在内表面和外表面之间延伸的圆柱形壁，圆柱形壁具有近侧端和远侧端，囊具有多个导电窗，其设置在壁中且能够在内表面和外表面之间传送电流，多个窗布置成使得沿着壁从壁的近侧端到壁的远侧端延伸最短距离的每根线穿过至少一个窗，其中，除了沿轴向方向之外，多个窗中的至少一个进一步沿周向方向延伸，并且其中，囊壁在别处是电绝缘的；以及
设置在囊中的电极。
52. 根据示例51的导管，其中，多个窗中的至少一个为矩圆形。
53. 根据示例51的导管，其中，多个窗中的至少一个为椭圆形。
54. 根据示例51的导管，其中，多个窗中的至少一个为钻石形。
55. 根据示例51的导管，其中，多个窗中的至少一个为蝶形领结形。
56. 根据示例51至55中的任一个的导管，其中，多个窗沿轴向彼此间隔开。
57. 根据示例51至56中的任一个的导管，其中，多个窗以螺旋形状布置在囊壁上。
58. 根据示例51至57中的任一个的导管，其中，任何两个相邻的窗沿周向交迭，使得沿着壁从壁的近侧端到壁的远侧端延伸最短距离的线穿过两个相邻的窗。
59. 根据示例58的导管，其中，任何两个相邻的窗具有至少0.3mm的周向交迭。
60. 根据示例58的导管，其中，任何两个相邻的窗具有至少0.4mm的周向交迭。
61. 根据示例58的导管，其中，任何两个相邻的窗具有至少0.5mm的周向交迭。
62. 根据示例58至61中的任一个的导管，其中，任何两个相邻的窗具有两个相邻的窗中的一个的周向尺寸的20%至30%的周向交迭。
63. 根据示例58至62中的任一个的导管，其中，任何两个相邻的窗具有两个相邻的窗中的一个的周向尺寸的24%至26%的周向交迭。
64. 根据示例58至63中的任一个的导管，其中，任何两个相邻的窗具有圆柱形囊壁的周向尺寸的6%至7%的周向交迭。
65. 根据示例58至63中的任一个的导管，其中，任何两个相邻的窗具有圆柱形囊壁的周向尺寸的10%至14%的周向交迭。
66. 根据示例51至65中的任一个的导管，其中，多个窗中的至少一个的周向尺寸与轴向尺寸的比率介于1.5:1和4:1之间。
67. 根据示例51至65中的任一个的导管，其中，多个窗中的至少一个的周向尺寸与轴向尺寸的比率为1.5:1。
68. 根据示例1至65中的任一个的导管，其中，多个窗中的至少一个的周向尺寸与轴向尺寸的比率为大约2:1和4:1。
69. 根据示例1至65中的任一个的导管，其中，多个窗中的至少一个的周向尺寸与轴向尺寸的比率为大约3:1。
70. 根据示例1至69中的任一个的导管，其中，多个窗中的各个的周向尺寸与轴向尺寸的比率相同。
71. 根据示例1至70中的任一个的导管，其中，多个窗中的各个为相同形状。
72. 根据示例1至71中的任一个的导管，其中，多个窗包括四个窗。
73. 根据示例1至72中的任一个的导管，其中，多个窗包括六个窗。
74. 根据示例1至73中的任一个的导管，其中，多个窗包括八个窗。
75. 根据示例1至74中的任一个的导管，其中，多个囊布置在网格的相交部上，其中，网格线为囊壁的多根周向线，并且多根螺旋线从囊壁的近侧端延伸到囊壁的远侧端。
76. 根据示例75的导管，其中，多根螺旋线围绕囊壁均等地间隔开。
77. 根据示例75至76中的任一个的导管，其中，多根螺旋线由两根螺旋线构成。
78. 根据示例75至76中的任一个的导管，其中，多根螺旋线由三根螺旋线构成。
79. 根据示例75至76中的任一个的导管，其中，多根螺旋线由四根螺旋线构成。
80. 根据示例75至79中的任一个的导管，其中，多根周向线以规则的间距间隔开。
81. 根据示例75至80中的任一个的导管，其中，多根周向线由两根周向线构成。
82. 根据示例75至80中的任一个的导管，其中，多根周向线由三根周向线构成。
83. 根据示例75至80中的任一个的导管，其中，多根周向线由四根周向线构成。
84. 根据示例51至83中的任一个的导管，其中，多个囊中的至少一个的周向尺寸为圆柱形囊壁的周长的20%至30%。
85. 根据示例51至84中的任一个的导管，其中，多个囊中的至少一个的周向尺寸为圆柱形囊壁的周长的22%至28%。
86. 根据示例51至85中的任一个的导管，其中，多个囊中的至少一个的周向尺寸为圆柱形囊壁的周长的24%至26%。
87. 根据示例51至86中的任一个的导管，其中，多个窗包含亲水性聚合物。
88. 根据示例51至87中的任一个的导管，其中，多个窗包括选自下者组成的组的亲水性聚合物：亲水性皮巴克斯、亲水性尼龙、亲水性聚酯，或具有亲水性嵌段的嵌段共聚物、皮巴克斯 MV1074、皮巴克斯 MV 1041、皮巴克斯 MP 1878、皮巴克斯 MV-3000、皮巴克斯 MH-1657。
89. 根据示例87至88中的任一个的导管，其中，多个窗包含与第二聚合物混合的亲水性聚合物。
90. 根据示例89的导管，其中，第二聚合物选自下者组成的组：皮巴克斯 6333、皮巴克斯 7033、皮巴克斯 7233、尼龙 12、维斯塔米德 L2101F、格里拉米德 L20和格里拉米德 L25。
91. 根据示例87至90中的任一个的导管，其中，亲水性聚合物具有20%至50%的亲水性。
92. 根据示例51至91中的任一个的导管，其中，囊壁包含非亲水性聚合物。
93. 根据示例51至92中的任一个的导管，其中，囊包括第一层和第二层。
94. 根据示例70的血管内导管，其中，第一层为导电的而第二层为不导电的。
95. 根据示例93至94中的任一个的血管内导管，其中，第一层在第二层的内侧。
96. 根据示例93至95中的任一个的血管内导管，其中，多个窗不包括第二层。
97. 根据示例93至96中的任一个的血管内导管，其中，多个窗基本由第一层构成。
98. 根据示例51至97中的任一个的血管内导管，其中，电极延伸囊的长度的至少50%。
99. 根据示例51至97中的任一个的血管内导管，其中，电极延伸囊的长度的至少80%。
100. 根据示例51至99中的任一个的血管内导管，其中，电极延伸囊的长度。
101. 根据示例51至99中的任一个的血管内导管，其中，电极为螺旋形。
102. 根据示例51至101中的任一个的血管内导管，其中，伸长部件延伸囊的长度。
103. 根据示例102的血管内导管，其中，电极设置在伸长部件的外表面上。
104. 根据示例102至103中的任一个的血管内导管，其中，伸长部件包括具有开口远侧端的引导线内腔。
105. 根据示例102至104中的任一个的血管内导管，其中，伸长部件进一步包括流体供应内腔，其具有流体地连接到囊内腔的开口。
106. 根据示例105的血管内导管，其中，伸长部件进一步包括流体返回内腔，其具有流体地连接到轴的开口。
107. 根据示例106的血管内导管，其中，流体供应内腔的开口在流体返回内腔的开口的远侧。
108. 根据示例107的血管内导管，其中，流体供应内腔的开口在囊的远侧腰部中。
109. 根据示例108的血管内导管，其中，流体返回内腔的开口在囊的近侧腰部中。
110. 根据示例51至109中的任一个的血管内导管，进一步包括温度传感器。
111. 根据示例110的血管内导管，其中，温度传感器设置在伸长部件上。
112. 根据示例110的血管内导管，其中，温度传感器设置在囊上。
113. 一种对神经进行调变的方法，包括：
提供根据示例1至112中的任一个的导管；
使囊移动到关注区域；
利用导电流体使囊膨胀；以及
激活电极。
114. 根据示例113的方法，其中，使囊移动到关注区域的步骤包括使导管在血管内前进的步骤。
115. 根据示例113至114中的任一个的方法，其中，使囊移动到关注区域的步骤包括使导管沿着引导线前进的步骤。
116. 根据示例113至115中的任一个的方法，其中，使囊膨胀的步骤包括使囊的外部壁接触关注区域的步骤。
117. 根据示例116的方法，进一步包括使流体以5毫升/分钟至10毫升/分钟的速率循环通过囊的步骤。
118. 根据示例114至117中的任一个的方法，其中，导电流体包括盐水。
119. 根据示例114至118中的任一个的方法，其中，导电流体包括高渗溶液。
120. 根据示例114至119中的任一个的方法，其中，导电流体包括对比溶液。
121. 根据示例113至120中的任一个的方法，进一步包括在使囊移动到关注区域之前使囊进行水合的步骤。
122. 根据示例121的方法，其中，使囊进行水合的步骤包括在盐溶液中浸泡囊的步骤。
123. 根据示例72的方法，其中，在盐溶液中浸泡囊的步骤包括在盐溶液中浸泡囊达至少一分钟。
124. 根据示例72的方法，其中，在盐溶液中浸泡囊的步骤包括在盐溶液中浸泡囊达至少五分钟。
在不脱离本发明的范围和原理的情况下，本发明的各种修改和变化对于本领域技术人员将变得显而易见，并且应当理解，本发明不应当不适当地限于本文在上面阐述的说明性实施例。所有出版物和专利通过引用而结合在本文中，达各个单独的出版物或专利特别和单独地被指示要通过引用而结合的程度。

Claims (15)

1.一种血管内导管，包括：
伸长部件，其具有近侧端和远侧端；
囊，其具有内表面和外表面、内腔，所述内腔由所述内表面限定且包括三个或更多个RF辐射可穿透的、从所述囊的内表面延伸到所述囊的外表面的区段，以及至少一个不导电区段；以及
设置在所述囊中的电极；
其中，所述囊包括第一层和第二层，并且
其中，所述第一层对于RF辐射是可穿透的，并且所述第二层为不导电的。
2.根据权利要求1所述的血管内导管，其特征在于，所述三个或更多个RF辐射可穿透的区段沿周向和纵向彼此间隔开。
3.根据权利要求1或2中的任一项所述的血管内导管，其特征在于，所述三个或更多个RF辐射可穿透的区段各自包含亲水性聚合物。
4.根据权利要求3所述的血管内导管，其特征在于，所述亲水性聚合物为亲水性聚氨酯。
5.根据权利要求3所述的导管，其特征在于，所述三个或更多个RF辐射可穿透的区段各种包含混合有第二聚合物的亲水性聚合物。
6.根据权利要求5所述的导管，其特征在于，所述第二聚合物选自下者组成的组：聚醚嵌段酰胺和尼龙12。
7.根据权利要求3所述的导管，其特征在于，所述亲水性聚合物具有20％至50％的吸水性。
8.根据权利要求1所述的导管，其特征在于，所述不导电区段包含非亲水性聚合物。
9.根据权利要求1所述的血管内导管，其特征在于，所述第一层在所述第二层的内侧。
10.根据权利要求1所述的血管内导管，其特征在于，所述三个或更多个RF辐射可穿透的区段不包括所述第二层，而是基本由所述第一层构成。
11.根据权利要求1所述的血管内导管，其特征在于，所述电极在三个或更多个RF可穿透的区段下面延伸。
12.根据权利要求1所述的血管内导管，其特征在于，所述电极为螺旋形。
13.根据权利要求1所述的血管内导管，其特征在于，所述伸长部件包括具有开口远侧端的引导线内腔。
14.根据权利要求1所述的血管内导管，其特征在于，所述伸长部件进一步包括：流体供应内腔，其具有流体地连接到所述囊内腔的开口；以及流体返回内腔，其具有流体地连接到所述囊内腔的开口。
15.根据权利要求14所述的血管内导管，其特征在于，所述流体供应内腔的开口在所述三个或更多个RF辐射可穿透的区段的远侧。
CN201280070846.1A 2011-12-28 2012-12-11 用有聚合物消融元件的新消融导管调变神经的装置和方法 Expired - Fee Related CN104135958B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161580972P 2011-12-28 2011-12-28
US61/580972 2011-12-28
US201261605624P 2012-03-01 2012-03-01
US201261605615P 2012-03-01 2012-03-01
US61/605615 2012-03-01
US61/605624 2012-03-01
PCT/US2012/068979 WO2013101452A1 (en) 2011-12-28 2012-12-11 Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements

Publications (2)

Publication Number Publication Date
CN104135958A CN104135958A (zh) 2014-11-05
CN104135958B true CN104135958B (zh) 2017-05-03

Family

ID=47430126

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280070846.1A Expired - Fee Related CN104135958B (zh) 2011-12-28 2012-12-11 用有聚合物消融元件的新消融导管调变神经的装置和方法

Country Status (4)

Country Link
US (2) US9433760B2 (zh)
EP (1) EP2797534A1 (zh)
CN (1) CN104135958B (zh)
WO (1) WO2013101452A1 (zh)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
EP3045136B1 (en) 2003-09-12 2021-02-24 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation of atherosclerotic material
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US20080091193A1 (en) * 2005-05-16 2008-04-17 James Kauphusman Irrigated ablation catheter having magnetic tip for magnetic field control and guidance
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
EP2992850A1 (en) 2006-10-18 2016-03-09 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
EP2076194B1 (en) 2006-10-18 2013-04-24 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
CA2743992A1 (en) 2008-11-17 2010-05-20 Minnow Medical, Inc. Selective accumulation of energy with or without knowledge of tissue topography
CN103068330B (zh) 2010-04-09 2016-06-29 Vessix血管股份有限公司 用于治疗组织的功率发生和控制装置
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
EP3100696B1 (en) 2010-10-25 2023-01-11 Medtronic Ardian Luxembourg S.à.r.l. Catheter apparatuses having multi-electrode arrays for renal neuromodulation
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
CA2832311A1 (en) 2011-04-08 2012-11-29 Covidien Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
CN103930061B (zh) 2011-04-25 2016-09-14 美敦力阿迪安卢森堡有限责任公司 用于限制导管壁低温消融的有关低温球囊限制部署的装置及方法
US9521990B2 (en) 2011-05-11 2016-12-20 Acist Medical Systems, Inc. Variable-stiffness imaging window and production method thereof
CN103813745B (zh) 2011-07-20 2016-06-29 波士顿科学西美德公司 用以可视化、对准和消融神经的经皮装置及方法
CN103813829B (zh) 2011-07-22 2016-05-18 波士顿科学西美德公司 具有可定位于螺旋引导件中的神经调制元件的神经调制系统
WO2013055826A1 (en) 2011-10-10 2013-04-18 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
EP2768568B1 (en) 2011-10-18 2020-05-06 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
CN108095821B (zh) 2011-11-08 2021-05-25 波士顿科学西美德公司 孔部肾神经消融
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
EP2793724B1 (en) 2011-12-23 2016-10-12 Vessix Vascular, Inc. Apparatuses for remodeling tissue of or adjacent to a body passage
CN104135958B (zh) 2011-12-28 2017-05-03 波士顿科学西美德公司 用有聚合物消融元件的新消融导管调变神经的装置和方法
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
WO2013169927A1 (en) * 2012-05-08 2013-11-14 Boston Scientific Scimed, Inc. Renal nerve modulation devices
CA2872189A1 (en) 2012-05-11 2013-11-14 William W. CHANG Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods
CN104540465A (zh) * 2012-08-24 2015-04-22 波士顿科学西美德公司 带有含单独微孔隙区域的球囊的血管内导管
CN104780859B (zh) 2012-09-17 2017-07-25 波士顿科学西美德公司 用于肾神经调节的自定位电极系统及方法
US10549127B2 (en) 2012-09-21 2020-02-04 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
WO2014047411A1 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
US20140088584A1 (en) * 2012-09-26 2014-03-27 Boston Scientific Scimed, Inc. Medical device balloon catheter
WO2014052648A1 (en) * 2012-09-26 2014-04-03 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US10835305B2 (en) 2012-10-10 2020-11-17 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
WO2014163987A1 (en) 2013-03-11 2014-10-09 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
CN105188587A (zh) * 2013-03-13 2015-12-23 波士顿科学医学有限公司 具有线性离子化传导性气球的可转向消融设备
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
CN106178294B (zh) * 2013-03-14 2018-11-20 瑞蔻医药有限公司 一种血管内的基于超声波的消融系统
US9297845B2 (en) 2013-03-15 2016-03-29 Boston Scientific Scimed, Inc. Medical devices and methods for treatment of hypertension that utilize impedance compensation
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
US9179974B2 (en) 2013-03-15 2015-11-10 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
JP6220044B2 (ja) 2013-03-15 2017-10-25 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経アブレーションのための医療用デバイス
JP2016523147A (ja) 2013-06-21 2016-08-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 同乗型電極支持体を備えた腎除神経バルーンカテーテル
US10022182B2 (en) 2013-06-21 2018-07-17 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation having rotatable shafts
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
WO2015002787A1 (en) 2013-07-01 2015-01-08 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US10413357B2 (en) 2013-07-11 2019-09-17 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
EP3019105B1 (en) * 2013-07-11 2017-09-13 Boston Scientific Scimed, Inc. Devices for nerve modulation
EP3019103A1 (en) * 2013-07-11 2016-05-18 Boston Scientific Scimed, Inc. Multiple electrode conductive balloon
CN105682594B (zh) 2013-07-19 2018-06-22 波士顿科学国际有限公司 螺旋双极电极肾脏去神经支配气囊
EP3024405A1 (en) 2013-07-22 2016-06-01 Boston Scientific Scimed, Inc. Renal nerve ablation catheter having twist balloon
EP3024406B1 (en) 2013-07-22 2019-06-19 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
WO2015027096A1 (en) 2013-08-22 2015-02-26 Boston Scientific Scimed, Inc. Flexible circuit having improved adhesion to a renal nerve modulation balloon
US9895194B2 (en) 2013-09-04 2018-02-20 Boston Scientific Scimed, Inc. Radio frequency (RF) balloon catheter having flushing and cooling capability
US20150073515A1 (en) 2013-09-09 2015-03-12 Medtronic Ardian Luxembourg S.a.r.I. Neuromodulation Catheter Devices and Systems Having Energy Delivering Thermocouple Assemblies and Associated Methods
EP3043733A1 (en) * 2013-09-13 2016-07-20 Boston Scientific Scimed, Inc. Ablation balloon with vapor deposited cover layer
US9687166B2 (en) 2013-10-14 2017-06-27 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
US9962223B2 (en) 2013-10-15 2018-05-08 Boston Scientific Scimed, Inc. Medical device balloon
EP3057521B1 (en) 2013-10-18 2020-03-25 Boston Scientific Scimed, Inc. Balloon catheters with flexible conducting wires
US10271898B2 (en) 2013-10-25 2019-04-30 Boston Scientific Scimed, Inc. Embedded thermocouple in denervation flex circuit
CN114533123A (zh) * 2013-12-19 2022-05-27 阿西斯特医疗系统有限公司 导管包壳系统和方法
EP3091922B1 (en) 2014-01-06 2018-10-17 Boston Scientific Scimed, Inc. Tear resistant flex circuit assembly
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
EP3424453A1 (en) 2014-02-04 2019-01-09 Boston Scientific Scimed, Inc. Alternative placement of thermal sensors on bipolar electrode
WO2015164280A1 (en) 2014-04-24 2015-10-29 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters having braided shafts and associated systems and methods
US10709490B2 (en) 2014-05-07 2020-07-14 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods
CN106456239A (zh) * 2014-05-28 2017-02-22 波士顿科学国际有限公司 具有冷却能力的神经调节器械
US10799287B2 (en) 2015-07-07 2020-10-13 Boston Scientific Scimed, Inc. Medical device having extenable members
JP7097876B2 (ja) * 2017-05-15 2022-07-08 テルモ株式会社 バルーンカテーテル、およびバルーンカテーテルの製造方法
EP3459469A1 (en) 2017-09-23 2019-03-27 Universität Zürich Medical occluder device
CN111202896A (zh) * 2018-11-05 2020-05-29 上海微创心通医疗科技有限公司 球囊扩张导管、球囊及其制备方法
US11045628B2 (en) 2018-12-11 2021-06-29 Biosense Webster (Israel) Ltd. Balloon catheter with high articulation
US11850051B2 (en) 2019-04-30 2023-12-26 Biosense Webster (Israel) Ltd. Mapping grid with high density electrode array
WO2021059273A2 (en) 2019-09-26 2021-04-01 Universitat Zurich Left atrial appendage occlusion devices
US11950930B2 (en) 2019-12-12 2024-04-09 Biosense Webster (Israel) Ltd. Multi-dimensional acquisition of bipolar signals from a catheter
US11517218B2 (en) 2019-12-20 2022-12-06 Biosense Webster (Israel) Ltd. Selective graphical presentation of electrophysiological parameters
US11950840B2 (en) 2020-09-22 2024-04-09 Biosense Webster (Israel) Ltd. Basket catheter having insulated ablation electrodes
US11950841B2 (en) 2020-09-22 2024-04-09 Biosense Webster (Israel) Ltd. Basket catheter having insulated ablation electrodes and diagnostic electrodes
US11918383B2 (en) 2020-12-21 2024-03-05 Biosense Webster (Israel) Ltd. Visualizing performance of catheter electrodes

Family Cites Families (1198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US164184A (en) 1875-06-08 Improvement in vesicular electrodes
US1167014A (en) 1915-06-25 1916-01-04 William R O'brien Veterinary surgical instrument.
US2505358A (en) 1949-04-20 1950-04-25 Sklar Mfg Co Inc J Double-cutting biopsy bistoury
US2701559A (en) 1951-08-02 1955-02-08 William A Cooper Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US3108593A (en) 1961-03-13 1963-10-29 Jacob A Glassman Surgical extractor
US3108594A (en) 1962-08-14 1963-10-29 Jacob A Glassman Surgical extractor and method of use
US3540431A (en) 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US6014590A (en) 1974-03-04 2000-01-11 Ep Technologies, Inc. Systems and methods employing structures having asymmetric mechanical properties to support diagnostic or therapeutic elements in contact with tissue in interior body regions
US3952747A (en) 1974-03-28 1976-04-27 Kimmell Jr Garman O Filter and filter insertion instrument
US3996938A (en) 1975-07-10 1976-12-14 Clark Iii William T Expanding mesh catheter
US4046150A (en) 1975-07-17 1977-09-06 American Hospital Supply Corporation Medical instrument for locating and removing occlusive objects
US4290427A (en) 1979-11-26 1981-09-22 Thomas J. Fogarty Endarterectomy apparatus
US4402686A (en) 1981-07-09 1983-09-06 Medel Gonzalo A Pinched nerve instrument
US4483341A (en) 1982-12-09 1984-11-20 Atlantic Richfield Company Therapeutic hypothermia instrument
US4784132A (en) 1983-03-25 1988-11-15 Fox Kenneth R Method of and apparatus for laser treatment of body lumens
EP0152766A1 (en) 1984-01-24 1985-08-28 Shiley Incorporated Reduction of an arteriosclerotic lesion by selective absorption of electromagnetic energy in a component thereof
US4574804A (en) 1984-02-27 1986-03-11 Board Of Regents, The University Of Texas System Optic nerve clamp
US4682596A (en) 1984-05-22 1987-07-28 Cordis Corporation Electrosurgical catheter and method for vascular applications
US4587975A (en) 1984-07-02 1986-05-13 Cardiac Pacemakers, Inc. Dimension sensitive angioplasty catheter
US5162217A (en) 1984-08-27 1992-11-10 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda PL promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US6030611A (en) 1984-08-27 2000-02-29 Bio-Technology General Corp. Therapeutic SOD compositions and uses thereof
US5143836A (en) 1984-08-27 1992-09-01 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda pl promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US4649936A (en) 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US4799479A (en) 1984-10-24 1989-01-24 The Beth Israel Hospital Association Method and apparatus for angioplasty
US5693043A (en) 1985-03-22 1997-12-02 Massachusetts Institute Of Technology Catheter for laser angiosurgery
US20020045811A1 (en) 1985-03-22 2002-04-18 Carter Kittrell Laser ablation process and apparatus
US5034010A (en) 1985-03-22 1991-07-23 Massachusetts Institute Of Technology Optical shield for a laser catheter
US5318024A (en) 1985-03-22 1994-06-07 Massachusetts Institute Of Technology Laser endoscope for spectroscopic imaging
US4862886A (en) 1985-05-08 1989-09-05 Summit Technology Inc. Laser angioplasty
US4709698A (en) 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
GB8622797D0 (en) 1986-09-22 1986-10-29 Allied Colloids Ltd Polymeric particles
US4784162A (en) 1986-09-23 1988-11-15 Advanced Medical Technologies Portable, multi-channel, physiological data monitoring system
US5231995A (en) 1986-11-14 1993-08-03 Desai Jawahar M Method for catheter mapping and ablation
US4785806A (en) 1987-01-08 1988-11-22 Yale University Laser ablation process and apparatus
US4790310A (en) 1987-02-04 1988-12-13 Robert Ginsburg Laser catheter having wide angle sweep
US4765331A (en) 1987-02-10 1988-08-23 Circon Corporation Electrosurgical device with treatment arc of less than 360 degrees
US4823791A (en) 1987-05-08 1989-04-25 Circon Acmi Division Of Circon Corporation Electrosurgical probe apparatus
US4770653A (en) 1987-06-25 1988-09-13 Medilase, Inc. Laser angioplasty
US4938766A (en) 1987-08-28 1990-07-03 Jarvik Robert K Prosthetic compliance devices
US5154705A (en) 1987-09-30 1992-10-13 Lake Region Manufacturing Co., Inc. Hollow lumen cable apparatus
US4788975B1 (en) 1987-11-05 1999-03-02 Trimedyne Inc Control system and method for improved laser angioplasty
US4887605A (en) 1988-02-18 1989-12-19 Angelsen Bjorn A J Laser catheter delivery system for controlled atheroma ablation combining laser angioplasty and intra-arterial ultrasonic imagining
US5372138A (en) 1988-03-21 1994-12-13 Boston Scientific Corporation Acousting imaging catheters and the like
US5178620A (en) 1988-06-10 1993-01-12 Advanced Angioplasty Products, Inc. Thermal dilatation catheter and method
US4830003A (en) 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
DE68922497T2 (de) 1988-08-24 1995-09-14 Marvin J Slepian Endoluminale dichtung mit bisdegradierbaren polymeren.
US4920979A (en) 1988-10-12 1990-05-01 Huntington Medical Research Institute Bidirectional helical electrode for nerve stimulation
US6066130A (en) 1988-10-24 2000-05-23 The General Hospital Corporation Delivering laser energy
US4955377A (en) 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US5129396A (en) 1988-11-10 1992-07-14 Arye Rosen Microwave aided balloon angioplasty with lumen measurement
ATE133545T1 (de) 1988-12-21 1996-02-15 Massachusetts Inst Technology Verfahren für laserinduzierte fluoreszenz von gewebe
US5697369A (en) 1988-12-22 1997-12-16 Biofield Corp. Method and apparatus for disease, injury and bodily condition screening or sensing
US5749914A (en) 1989-01-06 1998-05-12 Advanced Coronary Intervention Catheter for obstructed stent
WO1990007303A1 (en) 1989-01-06 1990-07-12 Angioplasty Systems, Inc. Electrosurgical catheter for resolving atherosclerotic plaque
US5779698A (en) 1989-01-18 1998-07-14 Applied Medical Resources Corporation Angioplasty catheter system and method for making same
US5052402A (en) 1989-01-31 1991-10-01 C.R. Bard, Inc. Disposable biopsy forceps
US5453091A (en) 1989-03-17 1995-09-26 Merit Medical Systems, Inc. RF transmission module for wirelessly transmitting balloon catheter data in a syringe inflation system
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5098431A (en) 1989-04-13 1992-03-24 Everest Medical Corporation RF ablation catheter
US5125928A (en) 1989-04-13 1992-06-30 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
JP3036835B2 (ja) 1989-08-18 2000-04-24 イーブイアイ コーポレイション カテーテルアテロトーム
US5211651A (en) 1989-08-18 1993-05-18 Evi Corporation Catheter atherotome
US5662701A (en) 1989-08-18 1997-09-02 Endovascular Instruments, Inc. Anti-stenotic method and product for occluded and partially occluded arteries
US5071424A (en) 1989-08-18 1991-12-10 Evi Corporation Catheter atherotome
US5156610A (en) 1989-08-18 1992-10-20 Evi Corporation Catheter atherotome
US5282484A (en) 1989-08-18 1994-02-01 Endovascular Instruments, Inc. Method for performing a partial atherectomy
DE69029141T2 (de) 1989-09-08 1997-04-10 Boston Scient Corp Angioplastie mit niedrigem physiologischen stress
US5109859A (en) 1989-10-04 1992-05-05 Beth Israel Hospital Association Ultrasound guided laser angioplasty
US5344395A (en) 1989-11-13 1994-09-06 Scimed Life Systems, Inc. Apparatus for intravascular cavitation or delivery of low frequency mechanical energy
US5074871A (en) 1989-12-07 1991-12-24 Evi Corporation Catheter atherotome
US5178625A (en) 1989-12-07 1993-01-12 Evi Corporation Catheter atherotome
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5158564A (en) 1990-02-14 1992-10-27 Angiomed Ag Atherectomy apparatus
US5084006A (en) 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device
US5098429A (en) 1990-04-17 1992-03-24 Mmtc, Inc. Angioplastic technique employing an inductively-heated ferrite material
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5190540A (en) 1990-06-08 1993-03-02 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
ATE123658T1 (de) 1990-06-15 1995-06-15 Cortrak Medical Inc Vorrichtung zur abgabe von medikamenten.
US5053033A (en) 1990-10-10 1991-10-01 Boston Advanced Technologies, Inc. Inhibition of restenosis by ultraviolet radiation
US5304171A (en) 1990-10-18 1994-04-19 Gregory Kenton W Catheter devices and methods for delivering
US5139496A (en) 1990-12-20 1992-08-18 Hed Aharon Z Ultrasonic freeze ablation catheters and probes
US6524274B1 (en) 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5170802A (en) 1991-01-07 1992-12-15 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5997497A (en) 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
US5447509A (en) 1991-01-11 1995-09-05 Baxter International Inc. Ultrasound catheter system having modulated output with feedback control
US5957882A (en) 1991-01-11 1999-09-28 Advanced Cardiovascular Systems, Inc. Ultrasound devices for ablating and removing obstructive matter from anatomical passageways and blood vessels
US5916192A (en) 1991-01-11 1999-06-29 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty-atherectomy catheter and method of use
US5368558A (en) 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having endoscopic component and method of using same
US5304115A (en) 1991-01-11 1994-04-19 Baxter International Inc. Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
US5267954A (en) 1991-01-11 1993-12-07 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5380274A (en) 1991-01-11 1995-01-10 Baxter International Inc. Ultrasound transmission member having improved longitudinal transmission properties
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5312328A (en) 1991-01-11 1994-05-17 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5405318A (en) 1992-05-05 1995-04-11 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5542917A (en) 1991-01-11 1996-08-06 Baxter International, Inc. Ultrasound delivery catheters incorporating improved distal tip construction
US5368557A (en) 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having multiple ultrasound transmission members
AU660444B2 (en) 1991-02-15 1995-06-29 Ingemar H. Lundquist Torquable catheter and method
US5234407A (en) 1991-03-06 1993-08-10 Baxter International Inc. Method and device for exchanging cardiovascular guide catheter while a previously inserted angioplasty guide wire remains in place
US5454788A (en) 1991-04-24 1995-10-03 Baxter International Inc. Exchangeable integrated-wire balloon catheter
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US6309379B1 (en) 1991-05-23 2001-10-30 Lloyd K. Willard Sheath for selective delivery of multiple intravascular devices and methods of use thereof
US5383917A (en) 1991-07-05 1995-01-24 Jawahar M. Desai Device and method for multi-phase radio-frequency ablation
US5270654A (en) 1991-07-05 1993-12-14 Feinberg David A Ultra-fast multi-section MRI using gradient and spin echo (grase) imaging
JPH0596012A (ja) 1991-10-07 1993-04-20 Olympus Optical Co Ltd 温熱治療装置
US5697909A (en) 1992-01-07 1997-12-16 Arthrocare Corporation Methods and apparatus for surgical cutting
EP0611293B1 (en) 1991-11-04 1998-03-25 Baxter International Inc. Ultrasonic ablation device adapted for guidewire passage
ATE241938T1 (de) 1991-11-08 2003-06-15 Boston Scient Ltd Ablationselektrode mit isoliertem temperaturmesselement
US5383874A (en) 1991-11-08 1995-01-24 Ep Technologies, Inc. Systems for identifying catheters and monitoring their use
US5906614A (en) 1991-11-08 1999-05-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods using predicted temperature for monitoring and control
US5498261A (en) 1991-12-20 1996-03-12 Advanced Cardiovascular Systems, Inc. Thermal angioplasty system
ATE144124T1 (de) 1991-12-20 1996-11-15 Technomed Medical Systems Schallwellen aussendende,thermische effekte und kavitationseffekte erzeugende vorrichtung fur die ultraschalltherapie
US5301683A (en) 1991-12-23 1994-04-12 Durkan John A Diagnosing carpal tunnel syndrome
US5522873A (en) 1991-12-26 1996-06-04 Webster Laboratories, Inc. Catheter having electrode with annular recess and method of using same
US5419767A (en) 1992-01-07 1995-05-30 Thapliyal And Eggers Partners Methods and apparatus for advancing catheters through severely occluded body lumens
US6179824B1 (en) 1993-05-10 2001-01-30 Arthrocare Corporation System and methods for electrosurgical restenosis of body lumens
US5681282A (en) 1992-01-07 1997-10-28 Arthrocare Corporation Methods and apparatus for ablation of luminal tissues
US5263493A (en) 1992-02-24 1993-11-23 Boaz Avitall Deflectable loop electrode array mapping and ablation catheter for cardiac chambers
US5242441A (en) 1992-02-24 1993-09-07 Boaz Avitall Deflectable catheter with rotatable tip electrode
US5330518A (en) 1992-03-06 1994-07-19 Urologix, Inc. Method for treating interstitial tissue associated with microwave thermal therapy
US5306250A (en) 1992-04-02 1994-04-26 Indiana University Foundation Method and apparatus for intravascular drug delivery
US5540681A (en) 1992-04-10 1996-07-30 Medtronic Cardiorhythm Method and system for radiofrequency ablation of tissue
US5573533A (en) 1992-04-10 1996-11-12 Medtronic Cardiorhythm Method and system for radiofrequency ablation of cardiac tissue
US5314466A (en) 1992-04-13 1994-05-24 Ep Technologies, Inc. Articulated unidirectional microwave antenna systems for cardiac ablation
US5300068A (en) 1992-04-21 1994-04-05 St. Jude Medical, Inc. Electrosurgical apparatus
US5810810A (en) 1992-04-23 1998-09-22 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
JPH07506991A (ja) 1992-04-23 1995-08-03 シメッド　ライフ　システムズ　インコーポレイテッド 血管穿刺を密封するための装置及び方法
US6063085A (en) 1992-04-23 2000-05-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
USRE40863E1 (en) 1992-04-23 2009-07-21 Boston Scientific Scimed, Inc. Apparatus and method for sealing vascular punctures
US5277201A (en) 1992-05-01 1994-01-11 Vesta Medical, Inc. Endometrial ablation apparatus and method
US5443470A (en) 1992-05-01 1995-08-22 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US5295484A (en) 1992-05-19 1994-03-22 Arizona Board Of Regents For And On Behalf Of The University Of Arizona Apparatus and method for intra-cardiac ablation of arrhythmias
US5255679A (en) 1992-06-02 1993-10-26 Cardiac Pathways Corporation Endocardial catheter for mapping and/or ablation with an expandable basket structure having means for providing selective reinforcement and pressure sensing mechanism for use therewith, and method
US5478351A (en) 1992-06-24 1995-12-26 Microsurge, Inc. Endoscopic surgical tool with handle and detachable tool assembly
DE69328096T2 (de) 1992-06-26 2000-09-14 Schneider Usa Inc Katheter mit ausdehnbarer maschendrahtspitze
US5382228A (en) 1992-07-09 1995-01-17 Baxter International Inc. Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device
US5365172A (en) 1992-08-07 1994-11-15 Brigham And Women's Hospital Methods and apparatus for MRI
US5297564A (en) 1992-08-27 1994-03-29 Love Jack W Catheter technique for creation of an aortico-pulmonary shunt
US5401272A (en) 1992-09-25 1995-03-28 Envision Surgical Systems, Inc. Multimodality probe with extendable bipolar electrodes
US5333614A (en) 1992-09-28 1994-08-02 Feiring Andrew J Measurement of absolute vascular flow
US5471982A (en) 1992-09-29 1995-12-05 Ep Technologies, Inc. Cardiac mapping and ablation systems
US6086581A (en) 1992-09-29 2000-07-11 Ep Technologies, Inc. Large surface cardiac ablation catheter that assumes a low profile during introduction into the heart
WO1994007446A1 (en) 1992-10-05 1994-04-14 Boston Scientific Corporation Device and method for heating tissue
CA2107741C (en) 1992-10-07 2000-06-27 Peter T. Keith Ablation devices and methods of use
US6398782B1 (en) 1992-10-13 2002-06-04 Edwards Lifesciences Corporation Bipolar vascular sealing apparatus and methods
US5432876C1 (en) 1992-10-19 2002-05-21 Minnesota Mining & Mfg Illumination devices and optical fibres for use therein
US5634901A (en) 1992-11-02 1997-06-03 Localmed, Inc. Method of using a catheter sleeve
US5643297A (en) 1992-11-09 1997-07-01 Endovascular Instruments, Inc. Intra-artery obstruction clearing apparatus and methods
US5571122A (en) 1992-11-09 1996-11-05 Endovascular Instruments, Inc. Unitary removal of plaque
US6923805B1 (en) 1992-11-13 2005-08-02 Scimed Life Systems, Inc. Electrophysiology energy treatment devices and methods of use
DE4338758C2 (de) 1992-11-13 2001-08-09 Scimed Life Systems Inc Katheteranordnung
WO1994010922A1 (en) 1992-11-13 1994-05-26 Ep Technologies, Inc. Cardial ablation systems using temperature monitoring
US6068653A (en) 1992-11-13 2000-05-30 Scimed Life Systems, Inc. Electrophysiology catheter device
US5676693A (en) 1992-11-13 1997-10-14 Scimed Life Systems, Inc. Electrophysiology device
US5545161A (en) 1992-12-01 1996-08-13 Cardiac Pathways Corporation Catheter for RF ablation having cooled electrode with electrically insulated sleeve
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5706809A (en) 1993-01-29 1998-01-13 Cardima, Inc. Method and system for using multiple intravascular sensing devices to detect electrical activity
CA2114988A1 (en) 1993-02-05 1994-08-06 Matthew O'boyle Ultrasonic angioplasty balloon catheter
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US6161543A (en) 1993-02-22 2000-12-19 Epicor, Inc. Methods of epicardial ablation for creating a lesion around the pulmonary veins
US6346074B1 (en) 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US5403311A (en) 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
US6915806B2 (en) 1993-05-10 2005-07-12 Arthrocare Corporation Method for harvesting graft vessel
US5693082A (en) 1993-05-14 1997-12-02 Fidus Medical Technology Corporation Tunable microwave ablation catheter system and method
US5364392A (en) 1993-05-14 1994-11-15 Fidus Medical Technology Corporation Microwave ablation catheter system with impedance matching tuner and method
US5405346A (en) 1993-05-14 1995-04-11 Fidus Medical Technology Corporation Tunable microwave ablation catheter
CA2165829A1 (en) 1993-07-01 1995-01-19 John E. Abele Imaging, electrical potential sensing, and ablation catheters
US5860974A (en) 1993-07-01 1999-01-19 Boston Scientific Corporation Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft
US5630837A (en) 1993-07-01 1997-05-20 Boston Scientific Corporation Acoustic ablation
US5584831A (en) 1993-07-09 1996-12-17 September 28, Inc. Spinal fixation device and method
US5409000A (en) 1993-09-14 1995-04-25 Cardiac Pathways Corporation Endocardial mapping and ablation system utilizing separately controlled steerable ablation catheter with ultrasonic imaging capabilities and method
US5843124A (en) 1993-09-28 1998-12-01 Hemodynamics, Inc. Surface opening adhesive sealer
US5417672A (en) 1993-10-04 1995-05-23 Baxter International Inc. Connector for coupling an ultrasound transducer to an ultrasound catheter
US5427118A (en) 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
US5496312A (en) 1993-10-07 1996-03-05 Valleylab Inc. Impedance and temperature generator control
WO1995010225A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Multiple electrode element for mapping and ablating
US5991650A (en) 1993-10-15 1999-11-23 Ep Technologies, Inc. Surface coatings for catheters, direct contacting diagnostic and therapeutic devices
US5797903A (en) 1996-04-12 1998-08-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures with electrically conductive surfaces
US5840076A (en) 1996-04-12 1998-11-24 Ep Technologies, Inc. Tissue heating and ablation systems and methods using electrode structures with distally oriented porous regions
US5599345A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
JP3400835B2 (ja) 1993-12-20 2003-04-28 テルモ株式会社 副伝導路検出装置
US5441498A (en) 1994-02-16 1995-08-15 Envision Surgical Systems, Inc. Method of using a multimodality probe with extendable bipolar electrodes
US5588962A (en) 1994-03-29 1996-12-31 Boston Scientific Corporation Drug treatment of diseased sites deep within the body
US5505201A (en) 1994-04-20 1996-04-09 Case Western Reserve University Implantable helical spiral cuff electrode
US5451207A (en) 1994-04-25 1995-09-19 The Regents Of The University Of California Method of coronary plaque removal with bypass and perfusion
US5715819A (en) 1994-05-26 1998-02-10 The Carolinas Heart Institute Microwave tomographic spectroscopy system and method
US5573531A (en) 1994-06-20 1996-11-12 Gregory; Kenton W. Fluid core laser angioscope
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US5505730A (en) 1994-06-24 1996-04-09 Stuart D. Edwards Thin layer ablation apparatus
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
ES2216016T3 (es) 1994-06-27 2004-10-16 Boston Scientific Limited Sistemas de control no lineal sobre el calentamiento del tejido corporal y los procedimientos de ablacion.
EP0768842A4 (en) 1994-06-27 1998-05-13 Ep Technologies SYSTEMS AND METHODS FOR TEMPERATURE MEASUREMENT IN THE BODY
US5735846A (en) 1994-06-27 1998-04-07 Ep Technologies, Inc. Systems and methods for ablating body tissue using predicted maximum tissue temperature
CA2194062C (en) 1994-06-27 2005-06-28 Dorin Panescu System for controlling tissue ablation using temperature sensors
WO1996002873A1 (en) 1994-07-19 1996-02-01 Hologram Technology International, Inc. Image recording medium and method of making same
US5810802A (en) 1994-08-08 1998-09-22 E.P. Technologies, Inc. Systems and methods for controlling tissue ablation using multiple temperature sensing elements
US5967976A (en) 1994-08-19 1999-10-19 Novoste Corporation Apparatus and methods for procedures related to the electrophysiology of the heart
US5531520A (en) 1994-09-01 1996-07-02 Massachusetts Institute Of Technology System and method of registration of three-dimensional data sets including anatomical body data
US8025661B2 (en) 1994-09-09 2011-09-27 Cardiofocus, Inc. Coaxial catheter instruments for ablation with radiant energy
US6572609B1 (en) 1999-07-14 2003-06-03 Cardiofocus, Inc. Phototherapeutic waveguide apparatus
US5647847A (en) 1994-09-16 1997-07-15 Scimed Life Systems, Inc. Balloon catheter with improved pressure source
US5876336A (en) 1994-10-11 1999-03-02 Ep Technologies, Inc. Systems and methods for guiding movable electrode elements within multiple-electrode structure
US5810742A (en) 1994-10-24 1998-09-22 Transcan Research & Development Co., Ltd. Tissue characterization based on impedance images and on impedance measurements
US5571151A (en) 1994-10-25 1996-11-05 Gregory; Kenton W. Method for contemporaneous application of laser energy and localized pharmacologic therapy
US5817144A (en) 1994-10-25 1998-10-06 Latis, Inc. Method for contemporaneous application OF laser energy and localized pharmacologic therapy
US6689086B1 (en) 1994-10-27 2004-02-10 Advanced Cardiovascular Systems, Inc. Method of using a catheter for delivery of ultrasonic energy and medicament
US5643255A (en) 1994-12-12 1997-07-01 Hicor, Inc. Steerable catheter with rotatable tip electrode and method of use
US5665062A (en) 1995-01-23 1997-09-09 Houser; Russell A. Atherectomy catheter and RF cutting method
US5776174A (en) 1995-01-30 1998-07-07 Illumenex Corporation Stabilization of vascular lesions by ultraviolet radiation
FR2729845B1 (fr) 1995-02-01 1997-07-25 Centre Nat Rech Scient Catheter d'imagerie echographique endocavitaire
US6409722B1 (en) 1998-07-07 2002-06-25 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US5695504A (en) 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5904697A (en) 1995-02-24 1999-05-18 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US6110187A (en) 1995-02-24 2000-08-29 Heartport, Inc. Device and method for minimizing heart displacements during a beating heart surgical procedure
WO1996026671A1 (en) 1995-02-28 1996-09-06 Boston Scientific Corporation Polymeric implements for torque transmission
US5797849A (en) 1995-03-28 1998-08-25 Sonometrics Corporation Method for carrying out a medical procedure using a three-dimensional tracking and imaging system
US6430446B1 (en) 1995-05-05 2002-08-06 Thermage, Inc. Apparatus for tissue remodeling
US5755753A (en) 1995-05-05 1998-05-26 Thermage, Inc. Method for controlled contraction of collagen tissue
US6425912B1 (en) 1995-05-05 2002-07-30 Thermage, Inc. Method and apparatus for modifying skin surface and soft tissue structure
US6241753B1 (en) 1995-05-05 2001-06-05 Thermage, Inc. Method for scar collagen formation and contraction
US5660836A (en) 1995-05-05 1997-08-26 Knowlton; Edward W. Method and apparatus for controlled contraction of collagen tissue
US6251104B1 (en) 1995-05-10 2001-06-26 Eclipse Surgical Technologies, Inc. Guiding catheter system for ablating heart tissue
US5782760A (en) 1995-05-23 1998-07-21 Cardima, Inc. Over-the-wire EP catheter
US5666964A (en) 1995-06-06 1997-09-16 Meilus; Algis A. Muscle treatment devices
US6190379B1 (en) 1995-06-06 2001-02-20 Sun Star Technology, Inc. Hot tip catheter
US6632193B1 (en) 1995-06-07 2003-10-14 Arthrocare Corporation Systems and methods for electrosurgical tissue treatment
US6837888B2 (en) 1995-06-07 2005-01-04 Arthrocare Corporation Electrosurgical probe with movable return electrode and methods related thereto
US6293943B1 (en) 1995-06-07 2001-09-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods which predict maximum tissue temperature
US5741248A (en) 1995-06-07 1998-04-21 Temple University-Of The Commonwealth System Of Higher Education Fluorochemical liquid augmented cryosurgery
AU710619B2 (en) 1995-06-23 1999-09-23 Gyrus Medical Limited An electrosurgical instrument
US6293942B1 (en) 1995-06-23 2001-09-25 Gyrus Medical Limited Electrosurgical generator method
US5702433A (en) 1995-06-27 1997-12-30 Arrow International Investment Corp. Kink-resistant steerable catheter assembly for microwave ablation
US8241217B2 (en) 1995-06-29 2012-08-14 Teratech Corporation Portable ultrasound imaging data
EP0835075A4 (en) 1995-06-30 1999-06-23 Boston Scient Corp CATHETER FOR ULTRASONIC IMAGING, WITH A CUTTING ELEMENT
US5693029A (en) 1995-07-10 1997-12-02 World Medical Manufacturing Corporation Pro-cell intra-cavity therapeutic agent delivery device
US5865801A (en) 1995-07-18 1999-02-02 Houser; Russell A. Multiple compartmented balloon catheter with external pressure sensing
US5800484A (en) 1995-08-15 1998-09-01 Rita Medical Systems, Inc. Multiple antenna ablation apparatus with expanded electrodes
US5672174A (en) 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US6763261B2 (en) 1995-09-20 2004-07-13 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US6090618A (en) 1996-10-07 2000-07-18 Arch Development Corporation DNA constructs and viral vectors comprising a smooth muscle promoter
EP1317908B1 (en) 1995-10-13 2011-07-06 Medtronic Vascular, Inc. A device and system for interstitial transvascular intervention
US6190353B1 (en) 1995-10-13 2001-02-20 Transvascular, Inc. Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures
US5846245A (en) 1995-10-20 1998-12-08 New York University Bone-adjusting device
US5833593A (en) 1995-11-09 1998-11-10 United States Surgical Corporation Flexible source wire for localized internal irradiation of tissue
US5817092A (en) 1995-11-09 1998-10-06 Radio Therapeutics Corporation Apparatus, system and method for delivering radio frequency energy to a treatment site
US5906623A (en) 1995-12-11 1999-05-25 Boston Scientific Corporation Lithotripsy system
US6350276B1 (en) 1996-01-05 2002-02-26 Thermage, Inc. Tissue remodeling apparatus containing cooling fluid
US5961513A (en) * 1996-01-19 1999-10-05 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures
US6475213B1 (en) 1996-01-19 2002-11-05 Ep Technologies, Inc. Method of ablating body tissue
US5830213A (en) 1996-04-12 1998-11-03 Ep Technologies, Inc. Systems for heating and ablating tissue using multifunctional electrode structures
US5836874A (en) 1996-04-08 1998-11-17 Ep Technologies, Inc. Multi-function electrode structures for electrically analyzing and heating body tissue
US5853411A (en) 1996-01-19 1998-12-29 Ep Technologies, Inc. Enhanced electrical connections for electrode structures
US5891136A (en) 1996-01-19 1999-04-06 Ep Technologies, Inc. Expandable-collapsible mesh electrode structures
US5846238A (en) 1996-01-19 1998-12-08 Ep Technologies, Inc. Expandable-collapsible electrode structures with distal end steering or manipulation
US5868736A (en) 1996-04-12 1999-02-09 Ep Technologies, Inc. Systems and methods to control tissue heating or ablation with porous electrode structures
US5871483A (en) 1996-01-19 1999-02-16 Ep Technologies, Inc. Folding electrode structures
US5846239A (en) 1996-04-12 1998-12-08 Ep Technologies, Inc. Tissue heating and ablation systems and methods using segmented porous electrode structures
WO1997025919A1 (en) 1996-01-19 1997-07-24 Ep Technologies, Inc. Systems and methods for heating and ablating tissue using multifunctional electrode structures
US5925038A (en) 1996-01-19 1999-07-20 Ep Technologies, Inc. Expandable-collapsible electrode structures for capacitive coupling to tissue
US5891135A (en) 1996-01-19 1999-04-06 Ep Technologies, Inc. Stem elements for securing tubing and electrical wires to expandable-collapsible electrode structures
US5879348A (en) 1996-04-12 1999-03-09 Ep Technologies, Inc. Electrode structures formed from flexible, porous, or woven materials
US6071278A (en) 1996-02-28 2000-06-06 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures with specified electrical resistivities
US6579311B1 (en) 1996-02-02 2003-06-17 Transvascular, Inc. Method for interstitial transvascular intervention
US6436056B1 (en) 1996-02-28 2002-08-20 Boston Scientific Corporation Polymeric implements for torque transmission
US6139527A (en) 1996-03-05 2000-10-31 Vnus Medical Technologies, Inc. Method and apparatus for treating hemorrhoids
US6036687A (en) 1996-03-05 2000-03-14 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency
EP0921765B1 (en) 1996-03-05 2007-05-02 Vnus Medical Technologies, Inc. Vascular catheter-based system for heating tissue
US6152899A (en) 1996-03-05 2000-11-28 Vnus Medical Technologies, Inc. Expandable catheter having improved electrode design, and method for applying energy
US6033397A (en) 1996-03-05 2000-03-07 Vnus Medical Technologies, Inc. Method and apparatus for treating esophageal varices
US5843016A (en) 1996-03-18 1998-12-01 Physion S.R.L. Electromotive drug administration for treatment of acute urinary outflow obstruction
US5690681A (en) 1996-03-29 1997-11-25 Purdue Research Foundation Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US5769880A (en) 1996-04-12 1998-06-23 Novacept Moisture transport system for contact electrocoagulation
US7604633B2 (en) 1996-04-12 2009-10-20 Cytyc Corporation Moisture transport system for contact electrocoagulation
US6813520B2 (en) 1996-04-12 2004-11-02 Novacept Method for ablating and/or coagulating tissue using moisture transport
US6673040B1 (en) 1996-04-16 2004-01-06 Cardeon Corporation System and methods for catheter procedures with circulatory support in high risk patients
US5904709A (en) 1996-04-17 1999-05-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microwave treatment for cardiac arrhythmias
US6022309A (en) 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
US20020045890A1 (en) 1996-04-24 2002-04-18 The Regents Of The University O F California Opto-acoustic thrombolysis
US6898454B2 (en) 1996-04-25 2005-05-24 The Johns Hopkins University Systems and methods for evaluating the urethra and the periurethral tissues
AUPN957296A0 (en) 1996-04-30 1996-05-23 Cardiac Crc Nominees Pty Limited A system for simultaneous unipolar multi-electrode ablation
US7022105B1 (en) 1996-05-06 2006-04-04 Novasys Medical Inc. Treatment of tissue in sphincters, sinuses and orifices
US6066139A (en) 1996-05-14 2000-05-23 Sherwood Services Ag Apparatus and method for sterilization and embolization
GB9612993D0 (en) 1996-06-20 1996-08-21 Gyrus Medical Ltd Electrosurgical instrument
US5882346A (en) 1996-07-15 1999-03-16 Cardiac Pathways Corporation Shapable catheter using exchangeable core and method of use
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5832228A (en) 1996-07-30 1998-11-03 Itt Industries, Inc. System and method for providing multi-level security in computer devices utilized with non-secure networks
US5755682A (en) 1996-08-13 1998-05-26 Heartstent Corporation Method and apparatus for performing coronary artery bypass surgery
US6684098B2 (en) 1996-08-16 2004-01-27 Brigham And Women's Hospital, Inc. Versatile stereotactic device and methods of use
US7203537B2 (en) 1996-08-19 2007-04-10 Mr3 Medical, Llc System and method for breaking reentry circuits by cooling cardiac tissue
US5800494A (en) 1996-08-20 1998-09-01 Fidus Medical Technology Corporation Microwave ablation catheters having antennas with distal fire capabilities
US6123679A (en) 1996-08-29 2000-09-26 Lafaut; Jean-Pierre Method for extracorporeal shock wave lithotripsy by applying an acoustic shock wave followed by a limited oscillating acoustic pressure wave train
US6451044B1 (en) 1996-09-20 2002-09-17 Board Of Regents, The University Of Texas System Method and apparatus for heating inflammed tissue
US5906636A (en) 1996-09-20 1999-05-25 Texas Heart Institute Heat treatment of inflamed tissue
US7603166B2 (en) 1996-09-20 2009-10-13 Board Of Regents University Of Texas System Method and apparatus for detection of vulnerable atherosclerotic plaque
US5957941A (en) 1996-09-27 1999-09-28 Boston Scientific Corporation Catheter system and drive assembly thereof
US5971975A (en) 1996-10-09 1999-10-26 Target Therapeutics, Inc. Guide catheter with enhanced guidewire tracking
US6464697B1 (en) 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
US5931834A (en) 1996-10-15 1999-08-03 Eclipse Surgical Technologies, Inc. Method for non-synchronous laser-assisted myocardial revascularization
US5785702A (en) 1996-10-15 1998-07-28 Eclipse Surgical Technologies, Inc. Method for non-synchronous laser-assisted transmyocardial revascularization
US5741249A (en) 1996-10-16 1998-04-21 Fidus Medical Technology Corporation Anchoring tip assembly for microwave ablation catheter
US5810803A (en) 1996-10-16 1998-09-22 Fidus Medical Technology Corporation Conformal positioning assembly for microwave ablation catheter
US6237605B1 (en) 1996-10-22 2001-05-29 Epicor, Inc. Methods of epicardial ablation
US5904651A (en) 1996-10-28 1999-05-18 Ep Technologies, Inc. Systems and methods for visualizing tissue during diagnostic or therapeutic procedures
US5848969A (en) 1996-10-28 1998-12-15 Ep Technologies, Inc. Systems and methods for visualizing interior tissue regions using expandable imaging structures
US5827268A (en) 1996-10-30 1998-10-27 Hearten Medical, Inc. Device for the treatment of patent ductus arteriosus and method of using the device
US6216704B1 (en) 1997-08-13 2001-04-17 Surx, Inc. Noninvasive devices, methods, and systems for shrinking of tissues
US6081749A (en) 1997-08-13 2000-06-27 Surx, Inc. Noninvasive devices, methods, and systems for shrinking of tissues
US5875782A (en) 1996-11-14 1999-03-02 Cardiothoracic Systems, Inc. Methods and devices for minimally invasive coronary artery revascularization on a beating heart without cardiopulmonary bypass
AU5431898A (en) 1996-11-21 1998-06-10 Boston Scientific Corporation Mucosal ablation using light
US6159187A (en) 1996-12-06 2000-12-12 Target Therapeutics, Inc. Reinforced catheter with a formable distal tip
US5999678A (en) 1996-12-27 1999-12-07 Eclipse Surgical Technologies, Inc. Laser delivery means adapted for drug delivery
CA2225521C (en) 1996-12-27 2004-04-06 Eclipse Surgical Technologies, Inc. Laser assisted drug delivery apparatus
US5775338A (en) 1997-01-10 1998-07-07 Scimed Life Systems, Inc. Heated perfusion balloon for reduction of restenosis
US7452538B2 (en) 1997-01-28 2008-11-18 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
US6342363B1 (en) 1997-01-28 2002-01-29 Human Genome Sciences, Inc. Death domain containing receptor 4 nucleic acids and methods
US8329179B2 (en) 1997-01-28 2012-12-11 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
JP2001512334A (ja) 1997-02-12 2001-08-21 プロリフィックス メディカル，インコーポレイテッド ステントから物質を除去する装置
US5989284A (en) 1997-02-18 1999-11-23 Hearten Medical, Inc. Method and device for soft tissue modification
US6120516A (en) 1997-02-28 2000-09-19 Lumend, Inc. Method for treating vascular occlusion
US7220257B1 (en) 2000-07-25 2007-05-22 Scimed Life Systems, Inc. Cryotreatment device and method
US5868735A (en) 1997-03-06 1999-02-09 Scimed Life Systems, Inc. Cryoplasty device and method
US6032675A (en) 1997-03-17 2000-03-07 Rubinsky; Boris Freezing method for controlled removal of fatty tissue by liposuction
US5904667A (en) 1997-03-17 1999-05-18 C.R. Bard, Inc. Rotatable control mechanism for steerable catheter
US5972026A (en) 1997-04-07 1999-10-26 Broncus Technologies, Inc. Bronchial stenter having diametrically adjustable electrodes
US6488673B1 (en) 1997-04-07 2002-12-03 Broncus Technologies, Inc. Method of increasing gas exchange of a lung
US7425212B1 (en) 1998-06-10 2008-09-16 Asthmatx, Inc. Devices for modification of airways by transfer of energy
US6524299B1 (en) 1997-04-09 2003-02-25 Target Therapeutics, Inc. Flow-directed catheter
WO1998046115A2 (en) 1997-04-11 1998-10-22 Transvascular, Inc. Methods and apparatus for transmyocardial direct coronary revascularization
US5827203A (en) 1997-04-21 1998-10-27 Nita; Henry Ultrasound system and method for myocardial revascularization
GB9708268D0 (en) 1997-04-24 1997-06-18 Gyrus Medical Ltd An electrosurgical instrument
US6117128A (en) 1997-04-30 2000-09-12 Kenton W. Gregory Energy delivery catheter and method for the use thereof
US6723063B1 (en) 1998-06-29 2004-04-20 Ekos Corporation Sheath for use with an ultrasound element
US6012457A (en) 1997-07-08 2000-01-11 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6024740A (en) 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US5989208A (en) 1997-05-16 1999-11-23 Nita; Henry Therapeutic ultrasound system
US6217576B1 (en) 1997-05-19 2001-04-17 Irvine Biomedical Inc. Catheter probe for treating focal atrial fibrillation in pulmonary veins
US5895378A (en) 1997-05-29 1999-04-20 Target Therapeutics, Inc. Flow-directed catheter having multiple tapers and radio-opaque markers
US6152912A (en) 1997-06-10 2000-11-28 Target Therapeutics, Inc. Optimized high performance spiral-wound vascular catheter
US5951539A (en) 1997-06-10 1999-09-14 Target Therpeutics, Inc. Optimized high performance multiple coil spiral-wound vascular catheter
CA2287206A1 (en) 1997-06-13 1998-12-17 Arthrocare Corporation Electrosurgical systems and methods for recanalization of occluded body lumens
US6855143B2 (en) 1997-06-13 2005-02-15 Arthrocare Corporation Electrosurgical systems and methods for recanalization of occluded body lumens
EP0989822A4 (en) 1997-06-23 2004-07-28 Focus Surgery Inc ACOUSTIC HEMOSTASIS METHODS AND DEVICES
WO1999000060A1 (en) 1997-06-26 1999-01-07 Advanced Coronary Intervention Electrosurgical catheter for resolving obstructions by radio frequency ablation
USRE40279E1 (en) 1997-06-26 2008-04-29 Sherwood Services Ag Method and system for neural tissue modification
US6251109B1 (en) * 1997-06-27 2001-06-26 Daig Corporation Process and device for the treatment of atrial arrhythmia
US6241666B1 (en) 1997-07-03 2001-06-05 Cardiac Pathways Corp. Ablation catheter tip with a buffer layer covering the electrode
US6547788B1 (en) 1997-07-08 2003-04-15 Atrionx, Inc. Medical device with sensor cooperating with expandable member
US6966908B2 (en) 1997-07-08 2005-11-22 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
ATE433306T1 (de) * 1997-07-08 2009-06-15 Univ California Vorrichtung zur zirkumferenziellen ablation
US6652515B1 (en) 1997-07-08 2003-11-25 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6869431B2 (en) 1997-07-08 2005-03-22 Atrionix, Inc. Medical device with sensor cooperating with expandable member
US6997925B2 (en) 1997-07-08 2006-02-14 Atrionx, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
US6500174B1 (en) 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US5891138A (en) 1997-08-11 1999-04-06 Irvine Biomedical, Inc. Catheter system having parallel electrodes
US9023031B2 (en) 1997-08-13 2015-05-05 Verathon Inc. Noninvasive devices, methods, and systems for modifying tissues
US5964757A (en) 1997-09-05 1999-10-12 Cordis Webster, Inc. Steerable direct myocardial revascularization catheter
US6402719B1 (en) 1997-09-05 2002-06-11 Cordis Webster, Inc. Steerable DMR catheter with infusion tube
US6258084B1 (en) 1997-09-11 2001-07-10 Vnus Medical Technologies, Inc. Method for applying energy to biological tissue including the use of tumescent tissue compression
US6179832B1 (en) 1997-09-11 2001-01-30 Vnus Medical Technologies, Inc. Expandable catheter having two sets of electrodes
US6401719B1 (en) 1997-09-11 2002-06-11 Vnus Medical Technologies, Inc. Method of ligating hollow anatomical structures
US6200312B1 (en) 1997-09-11 2001-03-13 Vnus Medical Technologies, Inc. Expandable vein ligator catheter having multiple electrode leads
US5954717A (en) 1997-09-25 1999-09-21 Radiotherapeutics Corporation Method and system for heating solid tissue
US8257725B2 (en) 1997-09-26 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6238389B1 (en) 1997-09-30 2001-05-29 Boston Scientific Corporation Deflectable interstitial ablation device
US5891114A (en) 1997-09-30 1999-04-06 Target Therapeutics, Inc. Soft-tip high performance braided catheter
US6007514A (en) 1997-09-30 1999-12-28 Nita; Henry Ultrasound system with pathfinding guidewire
KR100530607B1 (ko) 1997-10-08 2005-11-22 가부시키가이샤 가네가 풍선 카테테르 및 그 제조방법
US6231516B1 (en) 1997-10-14 2001-05-15 Vacusense, Inc. Endoluminal implant with therapeutic and diagnostic capability
US5935063A (en) 1997-10-29 1999-08-10 Irvine Biomedical, Inc. Electrode catheter system and methods thereof
US6156046A (en) 1997-11-07 2000-12-05 Prolifix Medical, Inc. Methods and systems for treating obstructions in a body lumen
US6120476A (en) 1997-12-01 2000-09-19 Cordis Webster, Inc. Irrigated tip catheter
US5971979A (en) 1997-12-02 1999-10-26 Odyssey Technologies, Inc. Method for cryogenic inhibition of hyperplasia
DE69921449T2 (de) 1998-01-12 2005-11-24 Ronald P. Lesser Verfahren zur behandlung von hirnleiden mittels gesteuerter wärmezufuhr
AU2114299A (en) 1998-01-14 1999-08-02 Conway-Stuart Medical, Inc. Electrosurgical device for sphincter treatment
JP4373605B2 (ja) 1998-01-26 2009-11-25 ボストン サイエンティフィック リミテッド 遠方誘導結合器および埋め込み伝送路を備えたカテーテルアセンブリ
US6517534B1 (en) 1998-02-11 2003-02-11 Cosman Company, Inc. Peri-urethral ablation
US6447505B2 (en) 1998-02-11 2002-09-10 Cosman Company, Inc. Balloon catheter method for intra-urethral radio-frequency urethral enlargement
US6651670B2 (en) 1998-02-13 2003-11-25 Ventrica, Inc. Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication
US6258087B1 (en) 1998-02-19 2001-07-10 Curon Medical, Inc. Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
US6273886B1 (en) 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US7165551B2 (en) 1998-02-19 2007-01-23 Curon Medical, Inc. Apparatus to detect and treat aberrant myoelectric activity
US6142993A (en) 1998-02-27 2000-11-07 Ep Technologies, Inc. Collapsible spline structure using a balloon as an expanding actuator
EP1059886A2 (en) 1998-03-02 2000-12-20 Atrionix, Inc. Tissue ablation system and method for forming long linear lesion
EP1059887A1 (en) 1998-03-06 2000-12-20 Curon Medical, Inc. Apparatus to electrosurgically treat esophageal sphincters
US6115626A (en) 1998-03-26 2000-09-05 Scimed Life Systems, Inc. Systems and methods using annotated images for controlling the use of diagnostic or therapeutic instruments in instruments in interior body regions
EP1071491A4 (en) 1998-03-30 2004-10-20 Univ Virginia STOP OF THE FLOW, DOUBLE BALLOON TECHNIQUE ALLOWING THE OCCLUSION OF ANNEVRISMS OR BLOOD VESSELS
US6200266B1 (en) 1998-03-31 2001-03-13 Case Western Reserve University Method and apparatus for ultrasound imaging using acoustic impedance reconstruction
US7001378B2 (en) 1998-03-31 2006-02-21 Innercool Therapies, Inc. Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
AU3212199A (en) 1998-03-31 1999-10-18 Scimed Life Systems, Inc. Temperature controlled solute delivery system
US6905494B2 (en) 1998-03-31 2005-06-14 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6142991A (en) 1998-03-31 2000-11-07 Galil Medical, Ltd. High resolution cryosurgical method and apparatus
US6666874B2 (en) 1998-04-10 2003-12-23 Endicor Medical, Inc. Rotational atherectomy system with serrated cutting tip
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US20020065542A1 (en) 1998-04-22 2002-05-30 Ronald G. Lax Method and apparatus for treating an aneurysm
US6161047A (en) 1998-04-30 2000-12-12 Medtronic Inc. Apparatus and method for expanding a stimulation lead body in situ
US6558378B2 (en) 1998-05-05 2003-05-06 Cardiac Pacemakers, Inc. RF ablation system and method having automatic temperature control
US6050994A (en) 1998-05-05 2000-04-18 Cardiac Pacemakers, Inc. RF ablation apparatus and method using controllable duty cycle with alternate phasing
US6066096A (en) 1998-05-08 2000-05-23 Duke University Imaging probes and catheters for volumetric intraluminal ultrasound imaging and related systems
US6508815B1 (en) 1998-05-08 2003-01-21 Novacept Radio-frequency generator for powering an ablation device
US6022901A (en) 1998-05-13 2000-02-08 Pharmascience Inc. Administration of resveratrol to prevent or treat restenosis following coronary intervention
US7494488B2 (en) 1998-05-28 2009-02-24 Pearl Technology Holdings, Llc Facial tissue strengthening and tightening device and methods
CA2345921C (en) 1998-06-12 2005-01-25 Cardiac Pacemakers, Inc. Modified guidewire for left ventricular access lead
US6121775A (en) 1998-06-16 2000-09-19 Beth Israel Deaconess Medical Center, Inc. MRI imaging method and apparatus
US6292695B1 (en) 1998-06-19 2001-09-18 Wilton W. Webster, Jr. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US6322559B1 (en) 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
US6394096B1 (en) 1998-07-15 2002-05-28 Corazon Technologies, Inc. Method and apparatus for treatment of cardiovascular tissue mineralization
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6228109B1 (en) 1998-08-31 2001-05-08 Lily Chen Tu Methods for treating atherosclerosis and vulnerable plaques
US5980563A (en) 1998-08-31 1999-11-09 Tu; Lily Chen Ablation apparatus and methods for treating atherosclerosis
US6251128B1 (en) 1998-09-01 2001-06-26 Fidus Medical Technology Corporation Microwave ablation catheter with loop configuration
US20050080374A1 (en) 1998-09-01 2005-04-14 Brady Esch Method and apparatus for treating acute myocardial infarction with selective hypothermic perfusion
US6123702A (en) 1998-09-10 2000-09-26 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6183468B1 (en) 1998-09-10 2001-02-06 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6489307B1 (en) 1998-09-14 2002-12-03 University Of Florida Antisense compositions targeted to β1-adrenoceptor-specific mRNA and methods of use
US6425867B1 (en) 1998-09-18 2002-07-30 University Of Washington Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy
US6299379B1 (en) 1998-09-18 2001-10-09 Lewis Hunting Accessories, Mfg., Inc. Reflective trail markers
US7722539B2 (en) 1998-09-18 2010-05-25 University Of Washington Treatment of unwanted tissue by the selective destruction of vasculature providing nutrients to the tissue
US6123703A (en) 1998-09-19 2000-09-26 Tu; Lily Chen Ablation catheter and methods for treating tissues
US20060240070A1 (en) 1998-09-24 2006-10-26 Cromack Keith R Delivery of highly lipophilic agents via medical devices
US6319251B1 (en) 1998-09-24 2001-11-20 Hosheng Tu Medical device and methods for treating intravascular restenosis
EP1115328A4 (en) 1998-09-24 2004-11-10 Super Dimension Ltd SYSTEM AND METHOD FOR LOCATING A CATHETER DURING AN ENDOCORPOREAL MEDICAL EXAMINATION
US8257724B2 (en) 1998-09-24 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6036689A (en) 1998-09-24 2000-03-14 Tu; Lily Chen Ablation device for treating atherosclerotic tissues
US6283935B1 (en) 1998-09-30 2001-09-04 Hearten Medical Ultrasonic device for providing reversible tissue damage to heart muscle
US6796981B2 (en) 1999-09-30 2004-09-28 Sherwood Services Ag Vessel sealing system
US7901400B2 (en) 1998-10-23 2011-03-08 Covidien Ag Method and system for controlling output of RF medical generator
US7137980B2 (en) 1998-10-23 2006-11-21 Sherwood Services Ag Method and system for controlling output of RF medical generator
US6123718A (en) 1998-11-02 2000-09-26 Polymerex Medical Corp. Balloon catheter
US6701176B1 (en) 1998-11-04 2004-03-02 Johns Hopkins University School Of Medicine Magnetic-resonance-guided imaging, electrophysiology, and ablation
US6673290B1 (en) 1998-11-12 2004-01-06 Scimed Life Systems, Inc. Electrode structure for heating and ablating tissue and method for making and assembling the same
US6210406B1 (en) 1998-12-03 2001-04-03 Cordis Webster, Inc. Split tip electrode catheter and signal processing RF ablation system
US6129725A (en) 1998-12-04 2000-10-10 Tu; Lily Chen Methods for reduction of restenosis
US6078839A (en) 1998-12-09 2000-06-20 Pacesetter, Inc. Abrasion resistant implantable lead insulation protector
US20070066972A1 (en) 2001-11-29 2007-03-22 Medwaves, Inc. Ablation catheter apparatus with one or more electrodes
EP1140278B1 (en) 1998-12-14 2004-05-19 Tre Esse Progettazione Biomedica S.r.l Catheter system for performing intramyocardiac therapeutic treatment
US7066900B2 (en) 1998-12-23 2006-06-27 Life Therapeutics Removal of metabolic components from blood
US6106477A (en) 1998-12-28 2000-08-22 Medtronic, Inc. Chronically implantable blood vessel cuff with sensor
US6296619B1 (en) 1998-12-30 2001-10-02 Pharmasonics, Inc. Therapeutic ultrasonic catheter for delivering a uniform energy dose
US6102908A (en) 1999-01-04 2000-08-15 Tu; Lily Chen Rotatable apparatus having ablation capabilities
AU1989100A (en) 1999-01-05 2000-07-24 Kaiku Limited Impedance measurements of bodily matter
US6206831B1 (en) 1999-01-06 2001-03-27 Scimed Life Systems, Inc. Ultrasound-guided ablation catheter and methods of use
US6228076B1 (en) 1999-01-09 2001-05-08 Intraluminal Therapeutics, Inc. System and method for controlling tissue ablation
US7481803B2 (en) 2000-11-28 2009-01-27 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US7122019B1 (en) 2000-11-28 2006-10-17 Flowmedica Inc. Intra-aortic renal drug delivery catheter
US7329236B2 (en) 1999-01-11 2008-02-12 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US6749598B1 (en) 1999-01-11 2004-06-15 Flowmedica, Inc. Apparatus and methods for treating congestive heart disease
US7780628B1 (en) 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
US6695830B2 (en) 1999-01-15 2004-02-24 Scimed Life Systems, Inc. Method for delivering medication into an arterial wall for prevention of restenosis
US6191862B1 (en) 1999-01-20 2001-02-20 Lightlab Imaging, Llc Methods and apparatus for high speed longitudinal scanning in imaging systems
US6423057B1 (en) 1999-01-25 2002-07-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method and apparatus for monitoring and controlling tissue temperature and lesion formation in radio-frequency ablation procedures
US6592526B1 (en) 1999-01-25 2003-07-15 Jay Alan Lenker Resolution ultrasound devices for imaging and treatment of body lumens
US6113615A (en) 1999-02-03 2000-09-05 Scimed Life Systems, Inc. Atherectomy burr including a bias wire
US6236883B1 (en) 1999-02-03 2001-05-22 The Trustees Of Columbia University In The City Of New York Methods and systems for localizing reentrant circuits from electrogram features
US6203537B1 (en) 1999-02-04 2001-03-20 Sorin Adrian Laser-driven acoustic ablation catheter
WO2000047118A1 (en) 1999-02-10 2000-08-17 Swaminathan Jayaraman Balloon catheter for cryotherapy and method of using same
US6855123B2 (en) 2002-08-02 2005-02-15 Flow Cardia, Inc. Therapeutic ultrasound system
CA2362332A1 (en) 1999-02-19 2000-08-24 Scimed Life Systems, Inc. Laser lithotripsy device with suction
US6514245B1 (en) 1999-03-15 2003-02-04 Cryovascular Systems, Inc. Safety cryotherapy catheter
US6432102B2 (en) 1999-03-15 2002-08-13 Cryovascular Systems, Inc. Cryosurgical fluid supply
US6648879B2 (en) 1999-02-24 2003-11-18 Cryovascular Systems, Inc. Safety cryotherapy catheter
US6428534B1 (en) 1999-02-24 2002-08-06 Cryovascular Systems, Inc. Cryogenic angioplasty catheter
US6468297B1 (en) 1999-02-24 2002-10-22 Cryovascular Systems, Inc. Cryogenically enhanced intravascular interventions
ATE298536T1 (de) 1999-03-09 2005-07-15 Thermage Inc Vorichtung zur behandlung von gewebe
US6484052B1 (en) 1999-03-30 2002-11-19 The Regents Of The University Of California Optically generated ultrasound for enhanced drug delivery
US6911026B1 (en) 1999-07-12 2005-06-28 Stereotaxis, Inc. Magnetically guided atherectomy
US6409723B1 (en) 1999-04-02 2002-06-25 Stuart D. Edwards Treating body tissue by applying energy and substances
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US20010007070A1 (en) 1999-04-05 2001-07-05 Medtronic, Inc. Ablation catheter assembly and method for isolating a pulmonary vein
US20050010095A1 (en) 1999-04-05 2005-01-13 Medtronic, Inc. Multi-purpose catheter apparatus and method of use
US6325797B1 (en) 1999-04-05 2001-12-04 Medtronic, Inc. Ablation catheter and method for isolating a pulmonary vein
WO2000062672A1 (en) 1999-04-15 2000-10-26 Surgi-Vision Methods for in vivo magnetic resonance imaging
US6577902B1 (en) 1999-04-16 2003-06-10 Tony R. Brown Device for shaping infarcted heart tissue and method of using the device
US6317615B1 (en) 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US6149647A (en) 1999-04-19 2000-11-21 Tu; Lily Chen Apparatus and methods for tissue treatment
US6595959B1 (en) 1999-04-23 2003-07-22 Alexander A. Stratienko Cardiovascular sheath/catheter
US6514236B1 (en) 1999-04-23 2003-02-04 Alexander A. Stratienko Method for treating a cardiovascular condition
US6245045B1 (en) 1999-04-23 2001-06-12 Alexander Andrew Stratienko Combination sheath and catheter for cardiovascular use
US6689142B1 (en) 1999-04-26 2004-02-10 Scimed Life Systems, Inc. Apparatus and methods for guiding a needle
JP2002543684A (ja) 1999-04-26 2002-12-17 シマゲ オユ 放射線撮像線用自己トリガー撮像デバイス
US7226446B1 (en) 1999-05-04 2007-06-05 Dinesh Mody Surgical microwave ablation assembly
US6648854B1 (en) 1999-05-14 2003-11-18 Scimed Life Systems, Inc. Single lumen balloon-tipped micro catheter with reinforced shaft
US7343195B2 (en) 1999-05-18 2008-03-11 Mediguide Ltd. Method and apparatus for real time quantitative three-dimensional image reconstruction of a moving organ and intra-body navigation
EP1180004A1 (en) 1999-05-18 2002-02-20 Silhouette Medical Inc. Surgical weight control device
US6692490B1 (en) 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
GB9911956D0 (en) 1999-05-21 1999-07-21 Gyrus Medical Ltd Electrosurgery system and method
US6375668B1 (en) 1999-06-02 2002-04-23 Hanson S. Gifford Devices and methods for treating vascular malformations
US6391024B1 (en) 1999-06-17 2002-05-21 Cardiac Pacemakers, Inc. RF ablation apparatus and method having electrode/tissue contact assessment scheme and electrocardiogram filtering
US6398792B1 (en) 1999-06-21 2002-06-04 O'connor Lawrence Angioplasty catheter with transducer using balloon for focusing of ultrasonic energy and method for use
SE519023C2 (sv) 1999-06-21 2002-12-23 Micromuscle Ab Kateterburna mikrokirurgiska verktygsset
US6546272B1 (en) 1999-06-24 2003-04-08 Mackinnon Nicholas B. Apparatus for in vivo imaging of the respiratory tract and other internal organs
US7840278B1 (en) 1999-06-25 2010-11-23 Puskas John D Devices and methods for vagus nerve stimulation
US7426409B2 (en) 1999-06-25 2008-09-16 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US6238392B1 (en) 1999-06-29 2001-05-29 Ethicon Endo-Surgery, Inc. Bipolar electrosurgical instrument including a plurality of balloon electrodes
US6179859B1 (en) 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US6508804B2 (en) 1999-07-28 2003-01-21 Scimed Life Systems, Inc. Catheter having continuous lattice and coil reinforcement
US6203561B1 (en) 1999-07-30 2001-03-20 Incept Llc Integrated vascular device having thrombectomy element and vascular filter and methods of use
US6235044B1 (en) 1999-08-04 2001-05-22 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of mycardial or vascular tissue
US7033372B1 (en) 1999-08-04 2006-04-25 Percardia, Inc. Corkscrew reinforced left ventricle to coronary artery channel
DE29913688U1 (de) 1999-08-05 1999-10-14 Wolf Gmbh Richard Transurethrale Dissektionselektrode
ATE258768T1 (de) 1999-08-05 2004-02-15 Broncus Tech Inc Verfahren und vorrichtungen zur herstellung von kollateralen kanälen in den lungen
US7175644B2 (en) 2001-02-14 2007-02-13 Broncus Technologies, Inc. Devices and methods for maintaining collateral channels in tissue
FR2797389B1 (fr) 1999-08-09 2001-11-30 Novatech Inc Prothese aortique bifurquee
US6445939B1 (en) 1999-08-09 2002-09-03 Lightlab Imaging, Llc Ultra-small optical probes, imaging optics, and methods for using same
US7288096B2 (en) 2003-01-17 2007-10-30 Origin Medsystems, Inc. Apparatus for placement of cardiac defibrillator and pacer
US6575966B2 (en) 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
US6283959B1 (en) 1999-08-23 2001-09-04 Cyrocath Technologies, Inc. Endovascular cryotreatment catheter
US6298256B1 (en) 1999-09-10 2001-10-02 Frank-Egbert Meyer Device and method for the location and catheterization of the surroundings of a nerve
US6454775B1 (en) 1999-12-06 2002-09-24 Bacchus Vascular Inc. Systems and methods for clot disruption and retrieval
NL1013084C2 (nl) 1999-09-17 2001-03-20 Neopost Bv Instellen van een systeem voor het samenstellen van poststukken.
US6829497B2 (en) 1999-09-21 2004-12-07 Jamil Mogul Steerable diagnostic catheters
JP2003510126A (ja) 1999-09-28 2003-03-18 ノヴァシス メディカル インコーポレイテッド エネルギーと薬の適用による組織の処置
US6485489B2 (en) 1999-10-02 2002-11-26 Quantum Cor, Inc. Catheter system for repairing a mitral valve annulus
US6514248B1 (en) 1999-10-15 2003-02-04 Neothermia Corporation Accurate cutting about and into tissue volumes with electrosurgically deployed electrodes
JP2001116565A (ja) 1999-10-15 2001-04-27 Yazaki Corp 車載ナビゲーション装置及び車載ナビゲーション装置における処理プログラムを記録した記録媒体
US6669655B1 (en) 1999-10-20 2003-12-30 Transurgical, Inc. Sonic element and catheter incorporating same
EP1229839A4 (en) 1999-10-25 2005-12-07 Therus Corp USING FOCUSED ULTRASOUND FOR VASCULAR SEALING
ES2299447T3 (es) 1999-11-10 2008-06-01 Cytyc Surgical Products Sistema para detectar perforaciones en una cavidad corporal.
US6529756B1 (en) 1999-11-22 2003-03-04 Scimed Life Systems, Inc. Apparatus for mapping and coagulating soft tissue in or around body orifices
US6542781B1 (en) 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
EP1237472A4 (en) 1999-11-24 2008-04-30 Nuvasive Inc SLEKTROMYOGRAPHIESYSTEM
US6280466B1 (en) 1999-12-03 2001-08-28 Teramed Inc. Endovascular graft system
US6592567B1 (en) 1999-12-07 2003-07-15 Chf Solutions, Inc. Kidney perfusion catheter
US7097641B1 (en) 1999-12-09 2006-08-29 Cryocath Technologies Inc. Catheter with cryogenic and heating ablation
US6800075B2 (en) 1999-12-10 2004-10-05 Sprite Solutions Method to inject and extract fluid at a treatment site to remove debris
US7494485B2 (en) 1999-12-10 2009-02-24 Sprite Solutions Fluidic interventional device and method of distal protection
US6480745B2 (en) 1999-12-24 2002-11-12 Medtronic, Inc. Information network interrogation of an implanted device
US6494891B1 (en) 1999-12-30 2002-12-17 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty transmission member
US6440125B1 (en) 2000-01-04 2002-08-27 Peter Rentrop Excimer laser catheter
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US6692450B1 (en) 2000-01-19 2004-02-17 Medtronic Xomed, Inc. Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same
US6447443B1 (en) 2001-01-13 2002-09-10 Medtronic, Inc. Method for organ positioning and stabilization
US6623453B1 (en) 2000-01-19 2003-09-23 Vanny Corporation Chemo-thermo applicator for cancer treatment
US7184827B1 (en) 2000-01-24 2007-02-27 Stuart D. Edwards Shrinkage of dilatations in the body
US6569109B2 (en) 2000-02-04 2003-05-27 Olympus Optical Co., Ltd. Ultrasonic operation apparatus for performing follow-up control of resonance frequency drive of ultrasonic oscillator by digital PLL system using DDS (direct digital synthesizer)
US6457365B1 (en) 2000-02-09 2002-10-01 Endosonics Corporation Method and apparatus for ultrasonic imaging
US6663622B1 (en) 2000-02-11 2003-12-16 Iotek, Inc. Surgical devices and methods for use in tissue ablation procedures
US6158250A (en) 2000-02-14 2000-12-12 Novacept Flat-bed knitting machine and method of knitting
US7499745B2 (en) 2000-02-28 2009-03-03 Barbara Ann Karmanos Cancer Institute Multidimensional bioelectrical tissue analyzer
US6394956B1 (en) 2000-02-29 2002-05-28 Scimed Life Systems, Inc. RF ablation and ultrasound catheter for crossing chronic total occlusions
US6770070B1 (en) 2000-03-17 2004-08-03 Rita Medical Systems, Inc. Lung treatment apparatus and method
US6458098B1 (en) 2000-03-17 2002-10-01 Nozomu Kanesaka Vascular therapy device
WO2001072373A2 (en) 2000-03-24 2001-10-04 Transurgical, Inc. Apparatus and method for intrabody thermal treatment
US6471696B1 (en) 2000-04-12 2002-10-29 Afx, Inc. Microwave ablation instrument with a directional radiation pattern
AU2001253654A1 (en) 2000-04-27 2001-11-12 Medtronic, Inc. Vibration sensitive ablation apparatus and method
US6558382B2 (en) 2000-04-27 2003-05-06 Medtronic, Inc. Suction stabilized epicardial ablation devices
US20020107514A1 (en) 2000-04-27 2002-08-08 Hooven Michael D. Transmural ablation device with parallel jaws
EP1642544B1 (en) 2000-05-03 2009-04-08 C.R.Bard, Inc. Apparatus for mapping and ablation in electrophysiology procedures
US6454766B1 (en) * 2000-05-05 2002-09-24 Scimed Life Systems, Inc. Microporous electrode structure and method of making the same
WO2001087172A1 (en) 2000-05-12 2001-11-22 Cardima, Inc. Multi-channel rf energy delivery with coagulum reduction
US7252664B2 (en) 2000-05-12 2007-08-07 Cardima, Inc. System and method for multi-channel RF energy delivery with coagulum reduction
US7006858B2 (en) 2000-05-15 2006-02-28 Silver James H Implantable, retrievable sensors and immunosensors
US7181261B2 (en) 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
US6442413B1 (en) 2000-05-15 2002-08-27 James H. Silver Implantable sensor
US6760616B2 (en) 2000-05-18 2004-07-06 Nu Vasive, Inc. Tissue discrimination and applications in medical procedures
US6544780B1 (en) 2000-06-02 2003-04-08 Genphar, Inc. Adenovirus vector with multiple expression cassettes
US6511500B1 (en) 2000-06-06 2003-01-28 Marc Mounir Rahme Use of autonomic nervous system neurotransmitters inhibition and atrial parasympathetic fibers ablation for the treatment of atrial arrhythmias and to preserve drug effects
US20020022864A1 (en) 2000-06-07 2002-02-21 Mahvi David M. Multipolar electrode system for radiofrequency ablation
ATE290827T1 (de) 2000-06-13 2005-04-15 Atrionix Inc Chirurgische ablationssonde zum formen einer ringförmigen läsion
US6477426B1 (en) 2000-06-20 2002-11-05 Celsion Corporation System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumors
US7837720B2 (en) 2000-06-20 2010-11-23 Boston Scientific Corporation Apparatus for treatment of tissue adjacent a bodily conduit with a gene or drug-coated compression balloon
US6958075B2 (en) 2001-09-18 2005-10-25 Celsion Corporation Device and method for treatment of tissue adjacent a bodily conduit by thermocompression
MXPA03000014A (es) 2000-06-28 2004-09-13 Ira Sanders Metodos para utilizar con fines beneficiosos toxina tetanica en animales.
US6511478B1 (en) 2000-06-30 2003-01-28 Scimed Life Systems, Inc. Medical probe with reduced number of temperature sensor wires
US6638277B2 (en) 2000-07-06 2003-10-28 Scimed Life Systems, Inc. Tumor ablation needle with independently activated and independently traversing tines
US20020095197A1 (en) 2000-07-11 2002-07-18 Lardo Albert C. Application of photochemotherapy for the treatment of cardiac arrhythmias
US6635054B2 (en) 2000-07-13 2003-10-21 Transurgical, Inc. Thermal treatment methods and apparatus with focused energy application
DE10038737A1 (de) 2000-08-02 2002-02-14 Oliver Wendt Katheter für magnetresonanztomographische Untersuchungen
US7678106B2 (en) 2000-08-09 2010-03-16 Halt Medical, Inc. Gynecological ablation procedure and system
US6699241B2 (en) 2000-08-11 2004-03-02 Northeastern University Wide-aperture catheter-based microwave cardiac ablation antenna
US7789876B2 (en) 2000-08-14 2010-09-07 Tyco Healthcare Group, Lp Method and apparatus for positioning a catheter relative to an anatomical junction
US20040010118A1 (en) 2000-08-16 2004-01-15 Zerhusen Bryan D. Novel proteins and nucleic acids encoding same
US6497711B1 (en) 2000-08-16 2002-12-24 Scimed Life Systems, Inc. Therectomy device having a light weight drive shaft and an imaging device
US6955174B2 (en) 2000-08-18 2005-10-18 Uryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
US6602246B1 (en) 2000-08-18 2003-08-05 Cryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
US6669692B1 (en) 2000-08-21 2003-12-30 Biosense Webster, Inc. Ablation catheter with cooled linear electrode
CN1466466A (zh) 2000-09-08 2004-01-07 ��һ��������ҩ��ʽ���� 心衰治疗剂
US6511496B1 (en) 2000-09-12 2003-01-28 Advanced Cardiovascular Systems, Inc. Embolic protection device for use in interventional procedures
US6985774B2 (en) 2000-09-27 2006-01-10 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US6522926B1 (en) 2000-09-27 2003-02-18 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US7158832B2 (en) 2000-09-27 2007-01-02 Cvrx, Inc. Electrode designs and methods of use for cardiovascular reflex control devices
US6845267B2 (en) 2000-09-28 2005-01-18 Advanced Bionics Corporation Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation
US6470219B1 (en) 2000-10-02 2002-10-22 Novasys Medical, Inc. Apparatus and method for treating female urinary incontinence
US6527765B2 (en) 2000-10-06 2003-03-04 Charles D. Kelman Cryogenic surgical system and method of use in removal of tissue
US6802857B1 (en) 2000-10-11 2004-10-12 Uab Research Foundation MRI stent
US6475215B1 (en) 2000-10-12 2002-11-05 Naim Erturk Tanrisever Quantum energy surgical device and method
US7104987B2 (en) 2000-10-17 2006-09-12 Asthmatx, Inc. Control system and process for application of energy to airway walls and other mediums
US7646544B2 (en) 2005-05-14 2010-01-12 Batchko Robert G Fluidic optical devices
US6706037B2 (en) 2000-10-24 2004-03-16 Galil Medical Ltd. Multiple cryoprobe apparatus and method
US6616624B1 (en) 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
US20070292411A1 (en) 2000-11-08 2007-12-20 Human Genome Sciences, Inc. Antibodies That Immunospecifically Bind to TRAIL Receptors
US20060062786A1 (en) 2000-11-08 2006-03-23 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US6673066B2 (en) 2000-11-10 2004-01-06 Cardiostream, Inc. Apparatus and method to diagnose and treat vulnerable plaque
US7314483B2 (en) 2000-11-16 2008-01-01 Cordis Corp. Stent graft with branch leg
US6942692B2 (en) 2000-11-16 2005-09-13 Cordis Corporation Supra-renal prosthesis and renal artery bypass
AU2001263143B2 (en) 2000-11-16 2006-12-07 Covidien Lp System and method of treating abnormal tissue in the human esophagus
WO2002045588A1 (de) 2000-11-24 2002-06-13 Innovacell Biotechnologie Gmbh Ultraschallsonde mit positioniereinrichtung für untersuchungs- und operationsvorrichtungen
US6579308B1 (en) 2000-11-28 2003-06-17 Scimed Life Systems, Inc. Stent devices with detachable distal or proximal wires
US7081114B2 (en) 2000-11-29 2006-07-25 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrophysiology/ablation catheter having lariat configuration of variable radius
US6676657B2 (en) 2000-12-07 2004-01-13 The United States Of America As Represented By The Department Of Health And Human Services Endoluminal radiofrequency cauterization system
US6659981B2 (en) 2000-12-08 2003-12-09 Medtronic, Inc. Medical device delivery catheter with distal locator
US6623452B2 (en) 2000-12-19 2003-09-23 Scimed Life Systems, Inc. Drug delivery catheter having a highly compliant balloon with infusion holes
US20020087151A1 (en) 2000-12-29 2002-07-04 Afx, Inc. Tissue ablation apparatus with a sliding ablation instrument and method
DE60238178D1 (de) 2001-01-16 2010-12-16 Cytyc Surgical Products Palo A Vorrichtung und verfahren zur behandlung des venösen reflux
US6569177B1 (en) 2001-01-19 2003-05-27 Scimed Life Systems, Inc. Ablation atherectomy burr
AU2002236790B2 (en) 2001-01-19 2006-08-17 Boston Scientific Limited Introducer for deployment of branched prosthesis
US20020107536A1 (en) 2001-02-07 2002-08-08 Hussein Hany M. Device and method for preventing kidney failure
US6823205B1 (en) 2001-02-08 2004-11-23 Boston University Radiology Associates Synthetic images for a magnetic resonance imaging scanner using linear combination of source images to generate contrast and spatial navigation
CN1496271B (zh) 2001-02-16 2010-04-28 阿斯比奥制药株式会社 伴随有aop-1基因或aop-1的表达减少的疾病的治疗方法以及该疾病的治疗药
AUPR333301A0 (en) 2001-02-23 2001-03-22 Northern Sydney Area Health Service Determining the volume of a normal heart and its pathological and treated variants by using dimension sensors
US6564096B2 (en) 2001-02-28 2003-05-13 Robert A. Mest Method and system for treatment of tachycardia and fibrillation
US6702763B2 (en) 2001-02-28 2004-03-09 Chase Medical, L.P. Sizing apparatus and method for use during ventricular restoration
US6666863B2 (en) 2001-03-01 2003-12-23 Scimed Life Systems, Inc. Device and method for percutaneous myocardial revascularization
US6786904B2 (en) 2002-01-10 2004-09-07 Triton Biosystems, Inc. Method and device to treat vulnerable plaque
AU2002309117A1 (en) 2001-03-08 2002-11-05 Avtandil Koridze Alkane and alkane group dehydrogenation with organometallic catalysts
US6570659B2 (en) 2001-03-16 2003-05-27 Lightlab Imaging, Llc Broadband light source system and method and light source combiner
US6623444B2 (en) 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
US20020147480A1 (en) 2001-04-04 2002-10-10 Mamayek Donald S. Treatment of lipid pool
US6552796B2 (en) 2001-04-06 2003-04-22 Lightlab Imaging, Llc Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography
US6764501B2 (en) 2001-04-10 2004-07-20 Robert A. Ganz Apparatus and method for treating atherosclerotic vascular disease through light sterilization
US6666858B2 (en) 2001-04-12 2003-12-23 Scimed Life Systems, Inc. Cryo balloon for atrial ablation
US20050232921A1 (en) 2001-04-13 2005-10-20 Rosen Craig A Vascular endothelial growth factor 2
US7402312B2 (en) 2001-04-13 2008-07-22 Human Genome Sciences, Inc. Antibodies to vascular endothelial growth factor 2 (VEGF-2)
US6989010B2 (en) 2001-04-26 2006-01-24 Medtronic, Inc. Ablation system and method of use
US6645223B2 (en) 2001-04-30 2003-11-11 Advanced Cardiovascular Systems, Inc. Deployment and recovery control systems for embolic protection devices
EP1418972A1 (en) 2001-05-01 2004-05-19 C.R. Bard, Inc. Method and apparatus for altering conduction properties along pathways in the heart and in vessels in conductive communication with the heart
US20020169444A1 (en) 2001-05-08 2002-11-14 Mest Robert A. Catheter having continuous braided electrode
US7160296B2 (en) 2001-05-10 2007-01-09 Rita Medical Systems, Inc. Tissue ablation apparatus and method
US20030130713A1 (en) 2001-05-21 2003-07-10 Stewart Mark T. Trans-septal catheter with retention mechanism
US6771996B2 (en) 2001-05-24 2004-08-03 Cardiac Pacemakers, Inc. Ablation and high-resolution mapping catheter system for pulmonary vein foci elimination
US20050214210A1 (en) 2001-05-25 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20050214209A1 (en) 2001-05-25 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
US20090226429A1 (en) 2001-05-25 2009-09-10 Human Genome Sciences, Inc. Antibodies That Immunospecifically Bind to TRAIL Receptors
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US20050129616A1 (en) 2001-05-25 2005-06-16 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
AU2002344234B2 (en) 2001-05-31 2007-11-08 Miravant Pharmaceuticals, Inc. Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy
US20020198520A1 (en) 2001-06-20 2002-12-26 Scimed Life Systems, Inc. Irrigation sheath
US6797933B1 (en) 2001-06-29 2004-09-28 Vanguard International Semiconductor Corporation On-chip design-for-testing structure for CMOS APS (active pixel sensor) image sensor
US20060167498A1 (en) 2001-07-23 2006-07-27 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
US20040043030A1 (en) 2001-07-31 2004-03-04 Immunomedics, Inc. Polymeric delivery systems
WO2003013368A1 (en) 2001-08-08 2003-02-20 Canica Design Inc. Surgical retractor and tissue stabilization device
US6786900B2 (en) 2001-08-13 2004-09-07 Cryovascular Systems, Inc. Cryotherapy methods for treating vessel dissections and side branch occlusion
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
WO2003017745A2 (en) 2001-08-23 2003-03-06 Sciperio, Inc. Architecture tool and methods of use
US8287524B2 (en) 2001-08-23 2012-10-16 Jerry Siegel Apparatus and method for performing radiation energy treatments
DE60203806T2 (de) 2001-08-31 2005-10-06 Boston Scientific Ltd., St. Michael Perkutane pringle-okklusionsvorrichtung
US6962584B1 (en) 2001-09-06 2005-11-08 Stone Gregg W Electromagnetic photonic catheter for reducing restenosis
US7252679B2 (en) 2001-09-13 2007-08-07 Cordis Corporation Stent with angulated struts
US20030065317A1 (en) 2001-09-19 2003-04-03 Rudie Eric N. Microwave ablation device
JP2005527474A (ja) 2001-09-20 2005-09-15 コーネル リサーチ ファンデーション インコーポレーテッド 前立腺特異的膜抗原に特異的な結合剤を用いて、皮膚障害を治療するかまたは防止するための方法および組成物
US6723043B2 (en) 2001-09-25 2004-04-20 Sdgi Holdings, Inc. Methods and devices for inserting and manipulating surgical instruments
JP3607231B2 (ja) 2001-09-28 2005-01-05 有限会社日本エレクテル 高周波加温バルーンカテーテル
EP1429678B1 (en) 2001-09-28 2006-03-22 Rita Medical Systems, Inc. Impedance controlled tissue ablation apparatus
JP2003111848A (ja) 2001-10-05 2003-04-15 Nihon Medix 加熱式バルーンカテーテル装置およびその加熱方法
CA2462968C (en) 2001-10-06 2012-11-20 Medos S.A. Method of setting and actuating a multi-stable micro valve and adjustable micro valve
US6814730B2 (en) 2001-10-09 2004-11-09 Hong Li Balloon catheters for non-continuous lesions
US6926716B2 (en) 2001-11-09 2005-08-09 Surgrx Inc. Electrosurgical instrument
AUPR847201A0 (en) 2001-10-26 2001-11-15 Cook Incorporated Endoluminal graft
US6807444B2 (en) 2001-11-05 2004-10-19 Hosheng Tu Apparatus and methods for monitoring tissue impedance
US20030092995A1 (en) 2001-11-13 2003-05-15 Medtronic, Inc. System and method of positioning implantable medical devices
US7317077B2 (en) 2001-11-16 2008-01-08 Nymox Pharmaceutical Corporation Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
WO2003043685A2 (en) 2001-11-19 2003-05-30 Cardiovascular Systems, Inc High torque, low profile intravascular guidewire system
US6895077B2 (en) 2001-11-21 2005-05-17 University Of Massachusetts Medical Center System and method for x-ray fluoroscopic imaging
WO2007136946A2 (en) 2001-12-03 2007-11-29 Xtent, Inc. Delivery catheter having active engagement mechanism for prosthesis
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
US6849075B2 (en) 2001-12-04 2005-02-01 Estech, Inc. Cardiac ablation devices and methods
US20050149069A1 (en) 2001-12-04 2005-07-07 Bertolero Arthur A. Left atrial appendage devices and methods
US6709431B2 (en) 2001-12-18 2004-03-23 Scimed Life Systems, Inc. Cryo-temperature monitoring
US20050214207A1 (en) 2001-12-20 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind toTRAIL receptors
US20050214205A1 (en) 2001-12-20 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20050214208A1 (en) 2001-12-20 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
AU2002361784A1 (en) 2001-12-20 2003-07-09 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US6972024B1 (en) 2001-12-21 2005-12-06 Advanced Cardiovascular Systems, Inc. Method of treating vulnerable plaque
US6893436B2 (en) 2002-01-03 2005-05-17 Afx, Inc. Ablation instrument having a flexible distal portion
US7326237B2 (en) 2002-01-08 2008-02-05 Cordis Corporation Supra-renal anchoring prosthesis
DE60336534D1 (de) 2002-01-11 2011-05-12 Gen Hospital Corp Vorrichtung zur OCT Bildaufnahme mit axialem Linienfokus für verbesserte Auflösung und Tiefenschärfe
US6790206B2 (en) 2002-01-31 2004-09-14 Scimed Life Systems, Inc. Compensation for power variation along patient cables
US6814733B2 (en) 2002-01-31 2004-11-09 Biosense, Inc. Radio frequency pulmonary vein isolation
US6826830B2 (en) 2002-02-05 2004-12-07 International Business Machines Corporation Multi-layered interconnect structure using liquid crystalline polymer dielectric
US6949121B1 (en) 2002-02-07 2005-09-27 Sentient Engineering & Technology, Llc Apparatus and methods for conduits and materials
MXPA04007897A (es) 2002-02-15 2004-11-26 Celsion Corp Metodo y aparato para tratar el tejido adyacente a un conducto corporal con termocompresion y farmacos.
US7192427B2 (en) 2002-02-19 2007-03-20 Afx, Inc. Apparatus and method for assessing transmurality of a tissue ablation
PL375045A1 (en) 2002-02-21 2005-11-14 Wyeth Gasp1: a follistatin domain containing protein
US7294127B2 (en) 2002-03-05 2007-11-13 Baylis Medical Company Inc. Electrosurgical tissue treatment method
US6824516B2 (en) 2002-03-11 2004-11-30 Medsci Technologies, Inc. System for examining, mapping, diagnosing, and treating diseases of the prostate
ATE369084T1 (de) 2002-03-15 2007-08-15 Bard Inc C R Apparat zur steuerung von ablationsenergie und elektrogrammaufnahme mittels einer vielzahl gemeinsamer elektroden in einem elektrophysiologie-katheter
ITBS20020039U1 (it) 2002-03-20 2003-09-22 Fogazzi Di Venturelli Andrea & Catetere con elettrodo flessibile raffreddato
WO2003079887A2 (en) 2002-03-21 2003-10-02 Radiant Medical, Inc. Measuring blood flow rate or cardiac output
US6979420B2 (en) 2002-03-28 2005-12-27 Scimed Life Systems, Inc. Method of molding balloon catheters employing microwave energy
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US20110207758A1 (en) 2003-04-08 2011-08-25 Medtronic Vascular, Inc. Methods for Therapeutic Renal Denervation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US20050256398A1 (en) 2004-05-12 2005-11-17 Hastings Roger N Systems and methods for interventional medicine
US6685733B1 (en) 2002-04-10 2004-02-03 Radiant Medical, Inc. Methods and systems for reducing substance-induced renal damage
US20030199747A1 (en) 2002-04-19 2003-10-23 Michlitsch Kenneth J. Methods and apparatus for the identification and stabilization of vulnerable plaque
US6989009B2 (en) 2002-04-19 2006-01-24 Scimed Life Systems, Inc. Cryo balloon
DE10217559B4 (de) 2002-04-19 2004-02-19 Universitätsklinikum Freiburg Vorrichtung zur minimalinvasiven, intravasalen Aortenklappenextraktion
US6746401B2 (en) 2002-05-06 2004-06-08 Scimed Life Systems, Inc. Tissue ablation visualization
EP1508157B1 (en) 2002-05-08 2011-11-23 Phoseon Technology, Inc. High efficiency solid-state light source and methods of use and manufacture
AUPS226402A0 (en) 2002-05-13 2002-06-13 Advanced Metal Coatings Pty Limited An ablation catheter
US6746474B2 (en) 2002-05-31 2004-06-08 Vahid Saadat Apparatus and methods for cooling a region within the body
US6748953B2 (en) 2002-06-11 2004-06-15 Scimed Life Systems, Inc. Method for thermal treatment of type II endoleaks in arterial aneurysms
US7153315B2 (en) 2002-06-11 2006-12-26 Boston Scientific Scimed, Inc. Catheter balloon with ultrasonic microscalpel blades
EP1517651B1 (en) 2002-06-28 2010-05-26 Cook Incorporated Thoracic aortic aneurysm stent graft
GB2390545B (en) 2002-07-09 2005-04-20 Barts & London Nhs Trust Hollow organ probe
US7769427B2 (en) 2002-07-16 2010-08-03 Magnetics, Inc. Apparatus and method for catheter guidance control and imaging
US6866662B2 (en) 2002-07-23 2005-03-15 Biosense Webster, Inc. Ablation catheter having stabilizing array
WO2004011076A2 (en) 2002-07-25 2004-02-05 Boston Scientific Limited Medical device for navigation through anatomy and method of making same
US8920826B2 (en) 2002-07-31 2014-12-30 Boston Scientific Scimed, Inc. Medical imaging reference devices
US6702748B1 (en) 2002-09-20 2004-03-09 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
TWI235073B (en) 2002-08-20 2005-07-01 Toray Industries Catheter for treating cardiac arrhythmias
US6991617B2 (en) 2002-08-21 2006-01-31 Hektner Thomas R Vascular treatment method and device
US7137963B2 (en) 2002-08-26 2006-11-21 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US7335180B2 (en) 2003-11-24 2008-02-26 Flowcardia, Inc. Steerable ultrasound catheter
US6942677B2 (en) 2003-02-26 2005-09-13 Flowcardia, Inc. Ultrasound catheter apparatus
US7220233B2 (en) 2003-04-08 2007-05-22 Flowcardia, Inc. Ultrasound catheter devices and methods
US7604608B2 (en) 2003-01-14 2009-10-20 Flowcardia, Inc. Ultrasound catheter and methods for making and using same
US6929639B2 (en) 2002-08-30 2005-08-16 Scimed Life Systems, Inc. Cryo ablation coil
WO2005037105A1 (en) 2002-09-20 2005-04-28 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
EP1585572A4 (en) 2002-09-20 2010-02-24 Flowmedica Inc METHOD AND APPARATUS FOR ADMINISTERING INTRA-AORTIC SUBSTANCE TO A BRANCHED VESSEL
US7282213B2 (en) 2002-09-30 2007-10-16 Medtronic, Inc. Method for applying a drug coating to a medical device
EP1405613B1 (en) 2002-10-04 2006-03-22 Sorin Biomedica Cardio S.R.L. An implant device for treating aneurisms of the abdominal aorta
US6673101B1 (en) 2002-10-09 2004-01-06 Endovascular Technologies, Inc. Apparatus and method for deploying self-expanding stents
US7493154B2 (en) 2002-10-23 2009-02-17 Medtronic, Inc. Methods and apparatus for locating body vessels and occlusions in body vessels
US7404824B1 (en) 2002-11-15 2008-07-29 Advanced Cardiovascular Systems, Inc. Valve aptation assist device
US7599730B2 (en) 2002-11-19 2009-10-06 Medtronic Navigation, Inc. Navigation system for cardiac therapies
US6926713B2 (en) 2002-12-11 2005-08-09 Boston Scientific Scimed, Inc. Angle indexer for medical devices
KR100887669B1 (ko) 2002-12-28 2009-03-11 엘지디스플레이 주식회사 액정표시장치 및 그 제조방법
US20050154277A1 (en) 2002-12-31 2005-07-14 Jing Tang Apparatus and methods of using built-in micro-spectroscopy micro-biosensors and specimen collection system for a wireless capsule in a biological body in vivo
EP1583569A4 (en) 2003-01-03 2009-05-06 Ekos Corp ULTRASONIC CATHETER COMPRISING AN AXIAL ENERGY FIELD
US6847848B2 (en) 2003-01-07 2005-01-25 Mmtc, Inc Inflatable balloon catheter structural designs and methods for treating diseased tissue of a patient
US7087051B2 (en) 2003-01-15 2006-08-08 Boston Scientific Scimed, Inc. Articulating radio frequency probe handle
US7083612B2 (en) 2003-01-15 2006-08-01 Cryodynamics, Llc Cryotherapy system
US7819866B2 (en) 2003-01-21 2010-10-26 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter and electrode
US6960207B2 (en) 2003-01-21 2005-11-01 St Jude Medical, Daig Division, Inc. Ablation catheter having a virtual electrode comprising portholes and a porous conductor
JP4067976B2 (ja) 2003-01-24 2008-03-26 有限会社日本エレクテル 高周波加温バルーンカテーテル
AU2004208580A1 (en) 2003-01-29 2004-08-12 E-Pill Pharma Ltd. Active drug delivery in the gastrointestinal tract
US20040193211A1 (en) 2003-02-14 2004-09-30 Voegele James W. Fingertip surgical instruments
US7201749B2 (en) 2003-02-19 2007-04-10 Biosense, Inc. Externally-applied high intensity focused ultrasound (HIFU) for pulmonary vein isolation
WO2004073505A2 (en) 2003-02-20 2004-09-02 Prorhythm, Inc. Cardiac ablation devices
US9603545B2 (en) 2003-02-21 2017-03-28 3Dt Holdings, Llc Devices, systems, and methods for removing targeted lesions from vessels
US7818053B2 (en) 2003-02-21 2010-10-19 Dtherapeutics, Llc Devices, systems and methods for plaque type determination
US8465452B2 (en) 2003-02-21 2013-06-18 3Dt Holdings, Llc Devices, systems, and methods for removing stenotic lesions from vessels
US6923808B2 (en) 2003-02-24 2005-08-02 Boston Scientific Scimed, Inc. Probes having helical and loop shaped inflatable therapeutic elements
US20040167506A1 (en) 2003-02-25 2004-08-26 Scimed Life Systems, Inc. Medical devices employing ferromagnetic heating
DE10308383A1 (de) 2003-02-27 2004-09-16 Storz Endoskop Produktions Gmbh Verfahren und optisches System zur Vermessung der Topographie eines Meßobjekts
US7250041B2 (en) 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US20050015125A1 (en) 2003-03-14 2005-01-20 Mioduski Paul C. Hyperthermia treatment systems and methods
US7792568B2 (en) 2003-03-17 2010-09-07 Boston Scientific Scimed, Inc. MRI-visible medical devices
US7293562B2 (en) 2003-03-27 2007-11-13 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US8021362B2 (en) 2003-03-27 2011-09-20 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7972330B2 (en) 2003-03-27 2011-07-05 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US6953425B2 (en) 2003-04-25 2005-10-11 Medtronic Vascular, Inc. Method of treating vulnerable plaque using a catheter-based radiation system
US7597704B2 (en) 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
US20040243022A1 (en) 2003-04-29 2004-12-02 Medtronic Vascular, Inc. Method and system of detecting vulnerable plaque by sensing motion of thin fibrous cap
WO2004098694A1 (en) 2003-05-02 2004-11-18 Boston Scientific Limited Multi-functional medical catheter
US7279600B2 (en) 2003-05-02 2007-10-09 Wyeth Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents
CN100344610C (zh) 2003-05-16 2007-10-24 惠氏公司 芳基－甲醛肟衍生物及其作为雌激素药物的用途
CL2004000985A1 (es) 2003-05-16 2005-01-14 Wyeth Corp Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc
JP2004337400A (ja) 2003-05-16 2004-12-02 Terumo Corp 薬剤投与キット
US7285120B2 (en) 2003-05-27 2007-10-23 Venture Manufacturing, Llc Balloon centered radially expanding ablation device
US7758520B2 (en) 2003-05-27 2010-07-20 Boston Scientific Scimed, Inc. Medical device having segmented construction
US6932776B2 (en) 2003-06-02 2005-08-23 Meridian Medicalssystems, Llc Method and apparatus for detecting and treating vulnerable plaques
US7529589B2 (en) 2003-06-04 2009-05-05 Synecor Llc Intravascular electrophysiological system and methods
US7738952B2 (en) 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
WO2004110258A2 (en) 2003-06-10 2004-12-23 Cardiofocus, Inc. Guided cardiac ablation catheters
US20080208169A1 (en) 2003-06-11 2008-08-28 Boyle Edward M Jr Body-Space Treatment Catheter
US7112196B2 (en) 2003-06-13 2006-09-26 Piezo Technologies, Inc. Multi-element array for acoustic ablation
DE10328816A1 (de) 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit
US7066895B2 (en) 2003-06-30 2006-06-27 Ethicon, Inc. Ultrasonic radial focused transducer for pulmonary vein ablation
US7678104B2 (en) 2003-07-17 2010-03-16 Biosense Webster, Inc. Ultrasound ablation catheter and method for its use
US7670335B2 (en) 2003-07-21 2010-03-02 Biosense Webster, Inc. Ablation device with spiral array ultrasound transducer
US7479157B2 (en) 2003-08-07 2009-01-20 Boston Scientific Scimed, Inc. Stent designs which enable the visibility of the inside of the stent during MRI
US7250440B2 (en) 2003-08-12 2007-07-31 Wyeth (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents
US7294125B2 (en) 2003-08-22 2007-11-13 Scimed Life Systems, Inc. Methods of delivering energy to body portions to produce a therapeutic response
US7313430B2 (en) 2003-08-28 2007-12-25 Medtronic Navigation, Inc. Method and apparatus for performing stereotactic surgery
US7569052B2 (en) 2003-09-12 2009-08-04 Boston Scientific Scimed, Inc. Ablation catheter with tissue protecting assembly
EP3045136B1 (en) 2003-09-12 2021-02-24 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation of atherosclerotic material
US7736362B2 (en) * 2003-09-15 2010-06-15 Boston Scientific Scimed, Inc. Catheter balloons
US7758510B2 (en) 2003-09-19 2010-07-20 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US7435248B2 (en) 2003-09-26 2008-10-14 Boston Scientific Scimed, Inc. Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel
US7280863B2 (en) 2003-10-20 2007-10-09 Magnetecs, Inc. System and method for radar-assisted catheter guidance and control
US7480532B2 (en) 2003-10-22 2009-01-20 Cvrx, Inc. Baroreflex activation for pain control, sedation and sleep
KR100573976B1 (ko) 2003-10-28 2006-04-26 삼성전자주식회사 전사벨트의 구동방법
EP1689457A2 (en) 2003-11-10 2006-08-16 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
WO2005046516A2 (en) 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and anti-scarring agents
EP1691852A2 (en) 2003-11-10 2006-08-23 Angiotech International AG Medical implants and fibrosis-inducing agents
US7367970B2 (en) 2003-11-11 2008-05-06 Biosense Webster Inc. Externally applied RF for pulmonary vein isolation
JP2007512077A (ja) 2003-11-25 2007-05-17 エフ．ディー． カルディオ リミテッド インフレーション・チューブを使用したステントの位置決め
WO2005053555A1 (de) 2003-12-01 2005-06-16 Biotronik Crm Patent Ag Elektrodenleitung für die elektrotherapie von herzgewebe
AU2004294324B2 (en) 2003-12-02 2010-05-27 Fuso Pharmaceutical Industries, Ltd. Dual-chamber container
US20050148842A1 (en) 2003-12-22 2005-07-07 Leming Wang Positioning devices and methods for in vivo wireless imaging capsules
JP4391221B2 (ja) 2003-12-22 2009-12-24 有限会社日本エレクテル 高周波加温バルーンカテーテル
JPWO2005065559A1 (ja) 2004-01-06 2007-12-20 東レ株式会社 バルーンカテーテル
US7326206B2 (en) 2004-01-16 2008-02-05 St. Jude Medical, Atrial Fibrillation Division, Inc. Conforming-electrode catheter and method for ablation
US7371231B2 (en) 2004-02-02 2008-05-13 Boston Scientific Scimed, Inc. System and method for performing ablation using a balloon
KR100605849B1 (ko) 2004-02-09 2006-08-01 삼성전자주식회사 휴대용 단말기의 데이터 저장 및 재생방법
US20050182479A1 (en) 2004-02-13 2005-08-18 Craig Bonsignore Connector members for stents
US7157492B2 (en) 2004-02-26 2007-01-02 Wyeth Dibenzo chromene derivatives and their use as ERβ selective ligands
US20050203410A1 (en) 2004-02-27 2005-09-15 Ep Medsystems, Inc. Methods and systems for ultrasound imaging of the heart from the pericardium
US7198632B2 (en) 2004-03-02 2007-04-03 Boston Scientific Scimed, Inc. Occlusion balloon catheter with longitudinally expandable balloon
US7662114B2 (en) 2004-03-02 2010-02-16 Focus Surgery, Inc. Ultrasound phased arrays
US8052636B2 (en) 2004-03-05 2011-11-08 Hansen Medical, Inc. Robotic catheter system and methods
US7247141B2 (en) 2004-03-08 2007-07-24 Ethicon Endo-Surgery, Inc. Intra-cavitary ultrasound medical system and method
US7238184B2 (en) 2004-03-15 2007-07-03 Boston Scientific Scimed, Inc. Ablation probe with peltier effect thermal control
US20080300618A1 (en) 2004-03-23 2008-12-04 Michael Eric Gertner Obesity treatment systems
US20060195139A1 (en) 2004-03-23 2006-08-31 Michael Gertner Extragastric devices and methods for gastroplasty
US20060142790A1 (en) 2004-03-23 2006-06-29 Michael Gertner Methods and devices to facilitate connections between body lumens
US8001976B2 (en) 2004-03-23 2011-08-23 Michael Gertner Management systems for the surgically treated obese patient
US7946976B2 (en) 2004-03-23 2011-05-24 Michael Gertner Methods and devices for the surgical creation of satiety and biofeedback pathways
US20050228415A1 (en) 2004-03-23 2005-10-13 Michael Gertner Methods and devices for percutaneous, non-laparoscopic treatment of obesity
US20070233170A1 (en) 2004-03-23 2007-10-04 Michael Gertner Extragastric Balloon
US20080071306A1 (en) 2004-03-23 2008-03-20 Michael Gertner Extragastric Balloon With Attachment Tabs
US9555223B2 (en) 2004-03-23 2017-01-31 Medtronic Cryocath Lp Method and apparatus for inflating and deflating balloon catheters
US7255675B2 (en) 2004-03-23 2007-08-14 Michael Gertner Devices and methods to treat a patient
US8343031B2 (en) 2004-03-23 2013-01-01 Michael Gertner Obesity treatment systems
WO2006049725A2 (en) 2004-03-23 2006-05-11 Minimus Surgical Systems Surgical systems and devices to enhance gastric restriction therapies
US7841978B2 (en) 2004-03-23 2010-11-30 Michael Gertner Methods and devices for to treatment of obesity
US20080147002A1 (en) 2004-03-23 2008-06-19 Michael Eric Gertner Obesity treatment systems
US7854733B2 (en) 2004-03-24 2010-12-21 Biosense Webster, Inc. Phased-array for tissue treatment
US20050214268A1 (en) 2004-03-25 2005-09-29 Cavanagh William A Iii Methods for treating tumors and cancerous tissues
JP4216810B2 (ja) 2004-03-30 2009-01-28 株式会社東芝 生体情報計測装置
US7323006B2 (en) 2004-03-30 2008-01-29 Xtent, Inc. Rapid exchange interventional devices and methods
US20050228286A1 (en) 2004-04-07 2005-10-13 Messerly Jeffrey D Medical system having a rotatable ultrasound source and a piercing tip
US20060018949A1 (en) 2004-04-07 2006-01-26 Bausch & Lomb Incorporated Injectable biodegradable drug delivery system
US7566319B2 (en) 2004-04-21 2009-07-28 Boston Scientific Scimed, Inc. Traction balloon
US20060004323A1 (en) 2004-04-21 2006-01-05 Exploramed Nc1, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US20050245862A1 (en) 2004-04-28 2005-11-03 Endobionics, Inc. Torque mechanism for interventional catheters
US20050251116A1 (en) 2004-05-05 2005-11-10 Minnow Medical, Llc Imaging and eccentric atherosclerotic material laser remodeling and/or ablation catheter
US7291142B2 (en) 2004-05-10 2007-11-06 Boston Scientific Scimed, Inc. Low temperature lesion formation apparatus, systems and methods
US7087053B2 (en) 2004-05-27 2006-08-08 St. Jude Medical, Atrial Fibrillation Division, Inc. Catheter with bifurcated, collapsible tip for sensing and ablating
US7527643B2 (en) 2004-05-28 2009-05-05 Cook Incorporated Exchangeable delivery system for expandable prosthetic devices
US20050267556A1 (en) 2004-05-28 2005-12-01 Allan Shuros Drug eluting implants to prevent cardiac apoptosis
WO2005120375A2 (en) 2004-06-02 2005-12-22 Medtronic, Inc. Loop ablation apparatus and method
US7640046B2 (en) 2004-06-18 2009-12-29 Cardiac Pacemakers, Inc. Methods and apparatuses for localizing myocardial infarction during catheterization
US7367975B2 (en) 2004-06-21 2008-05-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US7197354B2 (en) 2004-06-21 2007-03-27 Mediguide Ltd. System for determining the position and orientation of a catheter
US20060024564A1 (en) 2004-07-06 2006-02-02 Manclaw Ronald R Manclaw-Harrison fuel cell
WO2006015354A2 (en) 2004-07-30 2006-02-09 Washington University In St. Louis Electrosurgical systems and methods
US7799021B2 (en) 2004-08-04 2010-09-21 Kimberly-Clark Inc. Electrosurgical treatment in conjunction with monitoring
AP2007003921A0 (en) 2004-08-16 2007-02-28 Atugen Ag Therapeutic uses of inhibitors of rtp801
US7540852B2 (en) 2004-08-26 2009-06-02 Flowcardia, Inc. Ultrasound catheter devices and methods
JP2008512458A (ja) 2004-09-07 2008-04-24 ワイス ６Ｈ−［１］ベンゾピラノ［４，３−ｂ］キノリン及びエストロゲン様物質としてのそれらの使用
US20060095096A1 (en) 2004-09-09 2006-05-04 Debenedictis Leonard C Interchangeable tips for medical laser treatments and methods for using same
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US8545488B2 (en) 2004-09-17 2013-10-01 The Spectranetics Corporation Cardiovascular imaging system
US7458971B2 (en) 2004-09-24 2008-12-02 Boston Scientific Scimed, Inc. RF ablation probe with unibody electrode element
US20060069385A1 (en) 2004-09-28 2006-03-30 Scimed Life Systems, Inc. Methods and apparatus for tissue cryotherapy
US7635383B2 (en) 2004-09-28 2009-12-22 Boston Scientific Scimed, Inc. Rotating stent delivery system for side branch access and protection and method of using same
WO2006042047A1 (en) 2004-10-07 2006-04-20 Flea Street Translational, Llc Methods, systems and devices for establishing communication between hollow organs and tissue lumens
US20060089637A1 (en) 2004-10-14 2006-04-27 Werneth Randell L Ablation catheter
US7938830B2 (en) 2004-10-15 2011-05-10 Baxano, Inc. Powered tissue modification devices and methods
US7887538B2 (en) 2005-10-15 2011-02-15 Baxano, Inc. Methods and apparatus for tissue modification
US7962854B2 (en) 2004-10-19 2011-06-14 Sony Ericsson Mobile Communications Ab Systems, methods and computer program products for displaying content on multiple display screens using handheld wireless communicators
US20060083194A1 (en) 2004-10-19 2006-04-20 Ardian Dhrimaj System and method rendering audio/image data on remote devices
US20060089638A1 (en) 2004-10-27 2006-04-27 Yuval Carmel Radio-frequency device for passivation of vascular plaque and method of using same
US7753907B2 (en) 2004-10-29 2010-07-13 Boston Scientific Scimed, Inc. Medical device systems and methods
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US7200445B1 (en) 2005-10-21 2007-04-03 Asthmatx, Inc. Energy delivery devices and methods
US20090240249A1 (en) 2004-11-08 2009-09-24 Cardima, Inc. System and Method for Performing Ablation and Other Medical Procedures Using An Electrode Array with Flexible Circuit
WO2006055845A1 (en) 2004-11-15 2006-05-26 Cytyc Corporation System for drug delivery
US8617152B2 (en) 2004-11-15 2013-12-31 Medtronic Ablation Frontiers Llc Ablation system with feedback
JP2008520331A (ja) 2004-11-18 2008-06-19 トランスファーマ メディカル リミテッド 薬剤の経皮的送達のためのマイクロチャネル形成とイオントフォレーシスの組合せ
US20060167106A1 (en) 2004-11-19 2006-07-27 Mei Zhang Compounds acting at the centrosome
US7473890B2 (en) 2004-11-23 2009-01-06 New York University Manipulation of objects in potential energy landscapes
US20060247266A1 (en) 2004-11-26 2006-11-02 Asahi Kasei Pharma Corporation Nitrogen-containing tricyclic compounds
US8048144B2 (en) 2004-11-30 2011-11-01 Scimed Life Systems, Inc. Prosthesis fixation device and method
EP1819304B1 (en) 2004-12-09 2023-01-25 Twelve, Inc. Aortic valve repair
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
WO2006066610A1 (en) 2004-12-23 2006-06-29 Telecom Italia S.P.A. Method and system for video telephone communications set up, related equipment and computer program product
US20080009927A1 (en) 2005-01-11 2008-01-10 Vilims Bradley D Combination Electrical Stimulating and Infusion Medical Device and Method
US8007440B2 (en) 2005-02-08 2011-08-30 Volcano Corporation Apparatus and methods for low-cost intravascular ultrasound imaging and for crossing severe vascular occlusions
US7828837B2 (en) 2005-02-17 2010-11-09 Khoury Medical Devices, LLC. Vascular endograft
KR20160120809A (ko) 2005-03-04 2016-10-18 수캄포 아게 말초 혈관 질환 치료를 위한 방법 및 조성물
US7759315B2 (en) 2005-03-09 2010-07-20 Csl Behring Ag Treatment of inflammatory conditions of the intestine
US8801701B2 (en) 2005-03-09 2014-08-12 Sunnybrook Health Sciences Centre Method and apparatus for obtaining quantitative temperature measurements in prostate and other tissue undergoing thermal therapy treatment
US7674256B2 (en) 2005-03-17 2010-03-09 Boston Scientific Scimed, Inc. Treating internal body tissue
ATE533520T1 (de) 2005-03-23 2011-12-15 Abbott Lab Abgabe von stark lipophilen mitteln durch medizinprodukte
US7670337B2 (en) 2005-03-25 2010-03-02 Boston Scientific Scimed, Inc. Ablation probe having a plurality of arrays of electrodes
CN101511292B (zh) 2005-03-28 2011-04-06 明诺医学有限公司 用于选择性地治疗动脉粥样硬化和其他目标组织的内腔电组织表征和调谐射频能量
US20060224153A1 (en) 2005-04-05 2006-10-05 Fischell Robert E Catheter system for the treatment of atrial fibrillation
US7715912B2 (en) 2005-04-13 2010-05-11 Intelect Medical, Inc. System and method for providing a waveform for stimulating biological tissue
US8298224B2 (en) 2005-04-21 2012-10-30 Asthmatx, Inc. Control methods and devices for energy delivery
US20060239921A1 (en) 2005-04-26 2006-10-26 Novadaq Technologies Inc. Real time vascular imaging during solid organ transplant
US20060247760A1 (en) 2005-04-29 2006-11-02 Medtronic Vascular, Inc. Methods and apparatus for treatment of aneurysms adjacent branch arteries
US7505816B2 (en) 2005-04-29 2009-03-17 Medtronic, Inc. Actively cooled external energy source, external charger, system of transcutaneous energy transfer, system of transcutaneous charging and method therefore
US7806871B2 (en) 2005-05-09 2010-10-05 Boston Scientific Scimed, Inc. Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent
AU2006323195A1 (en) 2005-05-10 2007-06-14 Michael Gertner Obesity treatment systems
US7942874B2 (en) 2005-05-12 2011-05-17 Aragon Surgical, Inc. Apparatus for tissue cauterization
US20080091193A1 (en) 2005-05-16 2008-04-17 James Kauphusman Irrigated ablation catheter having magnetic tip for magnetic field control and guidance
WO2006127096A2 (en) 2005-05-20 2006-11-30 Omeros Corporation Cyclooxygenase inhibitor and calcium channel antagonist compositions and methods for use in urological procedures
US7767844B2 (en) 2005-05-23 2010-08-03 Atomic Energy Council Method for manufacturing diethylene triamine pentaacetic acid derivative
US10092429B2 (en) 2005-08-22 2018-10-09 Incept, Llc Flared stents and apparatus and methods for delivering them
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US7584004B2 (en) 2005-06-13 2009-09-01 Cardiac Pacemakers, Inc. Vascularly stabilized peripheral nerve cuff assembly
EP1895927A4 (en) 2005-06-20 2011-03-09 Medtronic Ablation Frontiers ABLATION CATHETER
US7717853B2 (en) 2005-06-24 2010-05-18 Henry Nita Methods and apparatus for intracranial ultrasound delivery
US20070016274A1 (en) 2005-06-29 2007-01-18 Boveja Birinder R Gastrointestinal (GI) ablation for GI tumors or to provide therapy for obesity, motility disorders, G.E.R.D., or to induce weight loss
AU2006263448B2 (en) 2005-06-29 2013-01-24 Radiant Medical, Inc. Devices, systems and methods for rapid endovascular cooling
WO2007005386A1 (en) 2005-06-30 2007-01-11 Rox Medical, Inc. Devices, systems, and methods for creation of a peripherally located fistula
DE102005032755B4 (de) 2005-07-13 2014-09-04 Siemens Aktiengesellschaft System zur Durchführung und Überwachung minimal-invasiver Eingriffe
US20070016184A1 (en) 2005-07-14 2007-01-18 Ethicon Endo-Surgery, Inc. Medical-treatment electrode assembly and method for medical treatment
EP1906853B1 (en) 2005-07-21 2017-09-06 Covidien LP Systems for treating a hollow anatomical structure
WO2007013065A2 (en) 2005-07-25 2007-02-01 Rainbow Medical Ltd. Electrical stimulation of blood vessels
AU2006272544B2 (en) 2005-07-26 2012-01-19 Rox Medical, Inc. Devices, systems, and methods for peripheral arteriovenous fistula creation
WO2007021804A2 (en) 2005-08-12 2007-02-22 Proteus Biomedical, Inc. Evaluation of depolarization wave conduction velocity
US7591996B2 (en) 2005-08-17 2009-09-22 University Of Washington Ultrasound target vessel occlusion using microbubbles
DE102005041601B4 (de) 2005-09-01 2010-07-08 Siemens Ag Ablationskatheter zum Setzen einer Läsion und Verfahren zur Herstellung eines Ablationskatheters
WO2007028258A2 (en) 2005-09-09 2007-03-15 Ottawa Health Research Institute Interpenetrating networks, and related methods and compositions
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
US20070073151A1 (en) 2005-09-13 2007-03-29 General Electric Company Automated imaging and therapy system
WO2007041593A2 (en) 2005-10-03 2007-04-12 Combinatorx, Incorporated Anti-scarring drug combinations and use thereof
US20070299043A1 (en) 2005-10-03 2007-12-27 Hunter William L Anti-scarring drug combinations and use thereof
DE102005050344A1 (de) 2005-10-20 2007-05-03 Siemens Ag Kryokatheter zur Einführung in ein Körpergefäß sowie medizinische Untersuchungs- und Behandlungsvorrichtung
US20070093697A1 (en) 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
US8257338B2 (en) 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
EP1946712B1 (en) 2005-11-01 2012-08-29 Japan Electel Inc. Balloon catheter system
US8052700B2 (en) 2005-11-02 2011-11-08 University Of Massachusetts Tissue clamp
US7901420B2 (en) 2005-11-02 2011-03-08 University Of Massachusetts Tissue clamp
US10716749B2 (en) 2005-11-03 2020-07-21 Palo Alto Investors Methods and compositions for treating a renal disease condition in a subject
WO2007055521A1 (en) 2005-11-09 2007-05-18 Korea University Industrial & Academic Collaboration Foundation Radio frequency ablation electrode for selected tissue removal
US7766833B2 (en) 2005-11-23 2010-08-03 General Electric Company Ablation array having independently activated ablation elements
US7959627B2 (en) 2005-11-23 2011-06-14 Barrx Medical, Inc. Precision ablating device
US8190238B2 (en) 2005-12-09 2012-05-29 Hansen Medical, Inc. Robotic catheter system and methods
US7776967B2 (en) 2005-12-16 2010-08-17 Continental Ag Polyorganosiloxane composition for use in unsaturated elastomer, article made therefrom, and associated method
US20080108867A1 (en) 2005-12-22 2008-05-08 Gan Zhou Devices and Methods for Ultrasonic Imaging and Ablation
US8031927B2 (en) 2005-12-28 2011-10-04 The General Hospital Corporation Medical image processing
US7896874B2 (en) 2005-12-29 2011-03-01 Boston Scientific Scimed, Inc. RF ablation probes with tine valves
US7993334B2 (en) 2005-12-29 2011-08-09 Boston Scientific Scimed, Inc. Low-profile, expanding single needle ablation probe
US8033284B2 (en) 2006-01-11 2011-10-11 Curaelase, Inc. Therapeutic laser treatment
US20070162109A1 (en) 2006-01-11 2007-07-12 Luis Davila Intraluminal stent graft
CA2574935A1 (en) 2006-01-24 2007-07-24 Sherwood Services Ag A method and system for controlling an output of a radio-frequency medical generator having an impedance based control algorithm
CA2641117C (en) 2006-01-31 2018-01-02 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US20070179496A1 (en) 2006-01-31 2007-08-02 Medtronic, Inc. Flexible catheter for ablation therapy
WO2007092330A1 (en) 2006-02-03 2007-08-16 Synecor, Llc Intravascular device for neuromodulation
US7918850B2 (en) 2006-02-17 2011-04-05 Biosense Wabster, Inc. Lesion assessment by pacing
US7869854B2 (en) 2006-02-23 2011-01-11 Magnetecs, Inc. Apparatus for magnetically deployable catheter with MOSFET sensor and method for mapping and ablation
US20070208210A1 (en) 2006-03-02 2007-09-06 G&L Consulting, Llc Method and apparatus to unload a failing heart
US20070208256A1 (en) 2006-03-03 2007-09-06 Medtronic Vascular, Inc. Multiple Branch Tubular Prosthesis and Methods
US8585753B2 (en) 2006-03-04 2013-11-19 John James Scanlon Fibrillated biodegradable prosthesis
US8027718B2 (en) 2006-03-07 2011-09-27 Mayo Foundation For Medical Education And Research Regional anesthetic
US7894905B2 (en) 2006-03-13 2011-02-22 Neuropace, Inc. Implantable system enabling responsive therapy for pain
US20070219576A1 (en) 2006-03-16 2007-09-20 Medtronic Vascular, Inc. Reversibly and Radially Expandable Electroactive Polymer Element for Temporary Occlusion of a Vessel
WO2007109171A2 (en) 2006-03-17 2007-09-27 Microcube, Llc Devices and methods for creating continuous lesions
US20070225781A1 (en) 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
EP2010085A1 (en) 2006-03-31 2009-01-07 Breval S.R.L. Device and method for the thermal ablation of tumors by means of high-frequency electromagnetic energy under overpressure conditions
US20080004673A1 (en) 2006-04-03 2008-01-03 Cvrx, Inc. Implantable extravascular electrostimulation system having a resilient cuff
JP5209603B2 (ja) 2006-04-13 2013-06-12 ミラビリス メディカ インコーポレイテッド 高密度焦点式超音波エネルギーの使用による機能性子宮出血、子宮内膜の病状、および子宮頸部の新形成の治療のための方法および装置
EP2010088A1 (en) 2006-04-14 2009-01-07 Koninklijke Philips Electronics N.V. Systems and methods for cardiac ablation using laser induced optical breakdown (liob)
US20080051454A1 (en) 2006-04-21 2008-02-28 The Board Of Trustees Operating Michigan State University Compositions and methods for transient receptor potential vanilloid (TRPV) channel mediated treatments
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
US7511494B2 (en) 2006-05-11 2009-03-31 The General Hospital Corporation Method for measuring the microarchitecture of complex tissue with MRI
EP3756604A1 (en) 2006-05-12 2020-12-30 Vytronus, Inc. Device for ablating body tissue
US7725157B2 (en) 2006-05-16 2010-05-25 General Electric Company System and method for interventional procedures using MRI
EP2032045A2 (en) 2006-05-24 2009-03-11 Emcision Limited Vessel sealing device and methods
US20080039746A1 (en) 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
CA2653864A1 (en) 2006-06-02 2007-12-13 Victhom Human Bionics Inc. Nerve cuff, method and apparatus for manufacturing same
WO2007141796A2 (en) 2006-06-09 2007-12-13 Quark Pharmaceuticals, Inc. Therapeutic uses of inhibitors of rtp801l
US20080097251A1 (en) 2006-06-15 2008-04-24 Eilaz Babaev Method and apparatus for treating vascular obstructions
EP2465574B1 (en) 2006-06-28 2015-10-28 Ardian, Inc. Systems for thermally-induced renal neuromodulation
JP2008010537A (ja) 2006-06-28 2008-01-17 Toshiba Corp Ｎａｎｄ型不揮発性半導体記憶装置およびｎａｎｄ型不揮発性半導体記憶装置の製造方法
CA2552620C (en) 2006-07-20 2014-07-15 Ruggedcom Inc. An anchoring member to facilitate fastening daughter boards to a mother board and a method for use
GB0614557D0 (en) 2006-07-21 2006-08-30 Emcision Ltd Tissue Ablator
US8452988B2 (en) 2006-07-24 2013-05-28 Michael Sujue Wang Secure data storage for protecting digital content
KR101794531B1 (ko) 2006-07-28 2017-11-07 메르츠 노스 아메리카 인코포레이티드 신경 전도를 제한하기 위한 절제 장치 및 시스템
US8409172B2 (en) 2006-08-03 2013-04-02 Hansen Medical, Inc. Systems and methods for performing minimally invasive procedures
US20090221955A1 (en) 2006-08-08 2009-09-03 Bacoustics, Llc Ablative ultrasonic-cryogenic methods
US20080039727A1 (en) 2006-08-08 2008-02-14 Eilaz Babaev Ablative Cardiac Catheter System
US8725225B2 (en) 2006-08-10 2014-05-13 University Of Rochester Intraoperative imaging of renal cortical tumors and cysts
WO2008022148A2 (en) 2006-08-14 2008-02-21 Stereotaxis, Inc. Method and apparatus for ablative recanalization of blocked vasculature
US20080243091A1 (en) 2006-08-22 2008-10-02 Mitchell R. Humphreys Process and System For Systematic Oxygenation and Renal Preservation During Retrograde Perfusion of the Ischemic Kidney
KR20090045940A (ko) 2006-08-29 2009-05-08 포휴먼텍(주) 세포자멸사의 억제를 위한 약학 조성물, 및 이를 전달하는 방법
US20080064957A1 (en) 2006-09-07 2008-03-13 Spence Paul A Ultrasonic implant, systems and methods related to diverting material in blood flow away from the head
US20080082109A1 (en) 2006-09-08 2008-04-03 Hansen Medical, Inc. Robotic surgical system with forward-oriented field of view guide instrument navigation
WO2008033867A2 (en) 2006-09-11 2008-03-20 Enbio Limited Method of doping surfaces
US20080071269A1 (en) 2006-09-18 2008-03-20 Cytyc Corporation Curved Endoscopic Medical Device
US8486060B2 (en) 2006-09-18 2013-07-16 Cytyc Corporation Power ramping during RF ablation
US7691080B2 (en) 2006-09-21 2010-04-06 Mercator Medsystems, Inc. Dual modulus balloon for interventional procedures
WO2008111960A2 (en) 2006-09-29 2008-09-18 University Of Akron Metal oxide fibers and nanofibers, method for making same, and uses thereof
US8617149B2 (en) 2006-10-02 2013-12-31 Boston Scientific Scimed, Inc. Common bond, double-balloon catheter
US8641660B2 (en) 2006-10-04 2014-02-04 P Tech, Llc Methods and devices for controlling biologic microenvironments
US7664548B2 (en) 2006-10-06 2010-02-16 Cardiac Pacemakers, Inc. Distributed neuromodulation system for treatment of cardiovascular disease
EP2076194B1 (en) 2006-10-18 2013-04-24 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
EP2992850A1 (en) 2006-10-18 2016-03-09 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
US7615072B2 (en) 2006-11-14 2009-11-10 Medtronic Vascular, Inc. Endoluminal prosthesis
US20080255550A1 (en) 2006-11-30 2008-10-16 Minos Medical Systems and methods for less invasive neutralization by ablation of tissue including the appendix and gall bladder
US20080140002A1 (en) 2006-12-06 2008-06-12 Kamal Ramzipoor System for delivery of biologically active substances with actuating three dimensional surface
US7699809B2 (en) 2006-12-14 2010-04-20 Urmey William F Catheter positioning system
US7846160B2 (en) 2006-12-21 2010-12-07 Cytyc Corporation Method and apparatus for sterilization
US20080208162A1 (en) 2007-02-26 2008-08-28 Joshi Ashok V Device and Method For Thermophoretic Fluid Delivery
US20080221448A1 (en) 2007-03-07 2008-09-11 Khuri-Yakub Butrus T Image-guided delivery of therapeutic tools duing minimally invasive surgeries and interventions
US8406877B2 (en) 2007-03-19 2013-03-26 Cardiac Pacemakers, Inc. Selective nerve stimulation with optionally closed-loop capabilities
JP5301527B2 (ja) 2007-03-30 2013-09-25 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 放射線治療及び他の治療を誘導するためのｍｒｉガイド下ｈｉｆｕマーキング
US8198611B2 (en) 2007-04-02 2012-06-12 Globalfoundries Inc. Laser beam formatting module and method for fabricating semiconductor dies using same
US9259233B2 (en) 2007-04-06 2016-02-16 Hologic, Inc. Method and device for distending a gynecological cavity
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US7495439B2 (en) 2007-04-27 2009-02-24 The General Hospital Corporation MRI method for reducing artifacts using RF pulse at offset frequency
US8641704B2 (en) 2007-05-11 2014-02-04 Medtronic Ablation Frontiers Llc Ablation therapy system and method for treating continuous atrial fibrillation
US11395694B2 (en) 2009-05-07 2022-07-26 St. Jude Medical, Llc Irrigated ablation catheter with multiple segmented ablation electrodes
CA2687876A1 (en) 2007-05-23 2009-03-05 Oscillon Ltd. Apparatus and method for guided chronic total occlusion penetration
US20080312673A1 (en) 2007-06-05 2008-12-18 Viswanathan Raju R Method and apparatus for CTO crossing
US8263104B2 (en) 2007-06-08 2012-09-11 Northwestern University Polymer nanofilm coatings
US20090210953A1 (en) 2007-06-08 2009-08-20 Bryan Moyer Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release
US20080312644A1 (en) 2007-06-14 2008-12-18 Boston Scientific Scimed, Inc. Cryogenic balloon ablation instruments and systems
US20090270850A1 (en) 2007-06-20 2009-10-29 Tea Time Partners, L.P., Organized In Texas Devices and methods for the ablation of tissue in the lateral direction
US20090018486A1 (en) 2007-07-13 2009-01-15 Menachem Goren Diagnosis and treatment of vericocele and prostate disorders
US8828068B2 (en) 2007-07-17 2014-09-09 Cardiac Pacemakers, Inc. Systems and methods for local vasoactive response using temperature modulation
US8702609B2 (en) 2007-07-27 2014-04-22 Meridian Cardiovascular Systems, Inc. Image-guided intravascular therapy catheters
US8821477B2 (en) 2007-08-06 2014-09-02 Boston Scientific Scimed, Inc. Alternative micromachined structures
KR101282285B1 (ko) 2007-08-20 2013-07-10 삼성전자주식회사 이동 통신 시스템에서 위치 기반 서비스 제공 시스템 및방법
US8066731B2 (en) 2007-08-20 2011-11-29 Olympus Medical Systems Corp. Treatment device
US7863897B2 (en) 2007-09-07 2011-01-04 The General Hospital Corporation Method and apparatus for characterizing the temporal resolution of an imaging device
US20090069671A1 (en) 2007-09-10 2009-03-12 General Electric Company Electric Motor Tracking System and Method
US7777486B2 (en) 2007-09-13 2010-08-17 The Board Of Trustees Of The Leland Stanford Junior University Magnetic resonance imaging with bipolar multi-echo sequences
US20090076502A1 (en) 2007-09-14 2009-03-19 Lazure Technologies, Llc. Prostate cancer ablation
US9283034B2 (en) 2007-09-26 2016-03-15 Retrovascular, Inc. Recanalization system using radiofrequency energy
JP5479672B2 (ja) 2007-09-27 2014-04-23 シスメックス株式会社 血液または尿の分析装置およびデータ処理装置
WO2009046441A1 (en) 2007-10-05 2009-04-09 Coaptus Medical Corporation Systems and methods for transeptal cardiac procedures
US20090157161A1 (en) 2007-10-24 2009-06-18 Edwards Lifesciences Corporation Percutaneous Nitinol Stent Extraction Device
WO2009055542A1 (en) 2007-10-26 2009-04-30 University Of Utah Research Foundation Use of mri contrast agents for evaluating the treatment of tumors
US20090112202A1 (en) 2007-10-31 2009-04-30 Boston Scientific Scimed, Inc. Dispersive electrode with thermochromatic properties
US20090118620A1 (en) 2007-11-06 2009-05-07 General Electric Company System and method for tracking an ultrasound catheter
US8613721B2 (en) 2007-11-14 2013-12-24 Medrad, Inc. Delivery and administration of compositions using interventional catheters
US20090131798A1 (en) 2007-11-19 2009-05-21 Minar Christopher D Method and apparatus for intravascular imaging and occlusion crossing
US20090143640A1 (en) 2007-11-26 2009-06-04 Voyage Medical, Inc. Combination imaging and treatment assemblies
WO2009068689A2 (en) 2007-11-30 2009-06-04 Novartis Ag Combination of protein tyrosine phosphatase inhibitors and human growth hormone for the treatment of muscle atrophy and related disorders
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8021413B2 (en) 2007-12-27 2011-09-20 Cook Medical Technologies Llc Low profile medical device
US20090171333A1 (en) 2007-12-27 2009-07-02 Boston Scientific Scimed, Inc. System and method for controllably delivering liquid coolant to a cryo-ablation device
US8273023B2 (en) 2009-01-05 2012-09-25 Texas Heart Institute Introducer sheathe with electrodes
US8366615B2 (en) 2009-01-05 2013-02-05 Texas Heart Institute Introducer sheath with electrodes
GB2456301A (en) 2008-01-08 2009-07-15 Gmj Design Ltd Surface Representation from a Point Cloud
US8676322B2 (en) 2008-01-30 2014-03-18 Boston Scientific Neuromodulation Corporation Methods and systems of treating pancreatitis pain
US8858609B2 (en) 2008-02-07 2014-10-14 Intuitive Surgical Operations, Inc. Stent delivery under direct visualization
US8738147B2 (en) 2008-02-07 2014-05-27 Cardiac Pacemakers, Inc. Wireless tissue electrostimulation
WO2009105482A1 (en) 2008-02-19 2009-08-27 Boston Scientific Scimed, Inc. Apparatus for uniformly distributing coolant within a cryo-ablation device
US20110040324A1 (en) 2008-03-17 2011-02-17 Mccarthy Patrick M Devices and methods for percutaneous access, hemostasis, and closure
US20090247933A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California; Angiodynamics, Inc. Balloon catheter method for reducing restenosis via irreversible electroporation
US20090247966A1 (en) 2008-03-28 2009-10-01 Gunn Euen T Methods and products for applying structured compositions to a substrate
US20090253974A1 (en) 2008-04-08 2009-10-08 Marc Mounir Rahme Use of tools, mapping systems, catheters, electrodes or any devices targeting any autonomic nerve(s) structure(s) in the human heart for the diagnostic, treatment and/or prevention of the recurrence of cardiac arrhythmias.
US20090264755A1 (en) 2008-04-22 2009-10-22 National Taiwan University High-Intensity Ultrasonic Vessel Ablator Using Blood Flow Signal for Precise Positioning
US7956613B2 (en) 2008-05-02 2011-06-07 The General Hospital Corporation Method for imaging acoustically induced rotary saturation with a magnetic resonance imaging system
WO2009137819A1 (en) 2008-05-09 2009-11-12 Innovative Pulmonary Solutions, Inc. Systems, assemblies, and methods for treating a bronchial tree
JP2011521679A (ja) 2008-05-12 2011-07-28 ボストン サイエンティフィック サイムド，インコーポレイテッド 冷凍アブレーションの冷却材を冷却する装置
US8480663B2 (en) 2008-05-15 2013-07-09 Boston Scientific Scimed, Inc. Apparatus and methods for cryogenically ablating tissue and adjusting cryogenic ablation regions
US8128617B2 (en) 2008-05-27 2012-03-06 Boston Scientific Scimed, Inc. Electrical mapping and cryo ablating with a balloon catheter
US8187261B2 (en) 2008-05-29 2012-05-29 Boston Scientific Scimed, Inc. Regulating internal pressure of a cryotherapy balloon catheter
US20090318749A1 (en) 2008-06-19 2009-12-24 Craig Stolen Method and apparatus for pacing and intermittent ischemia
US20100049099A1 (en) 2008-07-18 2010-02-25 Vytronus, Inc. Method and system for positioning an energy source
US20100030061A1 (en) 2008-07-31 2010-02-04 Canfield Monte R Navigation system for cardiac therapies using gating
US9211155B2 (en) 2008-08-20 2015-12-15 Prostacare Pty Ltd. Non-thermal ablation system for treating BPH and other growths
WO2010022314A1 (en) 2008-08-21 2010-02-25 Med-El Elektromedizinische Geraete Gmbh Multipath stimulation hearing systems
WO2010022367A2 (en) 2008-08-21 2010-02-25 Bliss Holdings, Llc Illumination-based medical device and methods of use thereof
US20100069837A1 (en) 2008-09-16 2010-03-18 Boston Scientific Scimed, Inc. Balloon Assembly and Method for Therapeutic Agent Delivery
EP2341839B1 (en) 2008-09-22 2015-10-21 Vessix Vascular, Inc. System for vascular ultrasound treatments
DE102008048616B4 (de) 2008-09-23 2010-08-05 Olympus Winter & Ibe Gmbh Urologischer Ballonkatheter
DE102008050347B4 (de) 2008-10-02 2011-01-20 Siemens Aktiengesellschaft Verfahren, Magnetresonanzanlage und Datenträger zur Bestimmung eines Nierenfunktionsparameters
EP2349440B1 (en) 2008-10-07 2019-08-21 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US8372068B2 (en) 2008-10-21 2013-02-12 Hermes Innovations, LLC Tissue ablation systems
US20100114244A1 (en) 2008-10-31 2010-05-06 Medtronic, Inc. Electrical renal autonomic blockade
WO2010056771A1 (en) 2008-11-11 2010-05-20 Shifamed Llc Low profile electrode assembly
US9468364B2 (en) 2008-11-14 2016-10-18 Intuitive Surgical Operations, Inc. Intravascular catheter with hood and image processing systems
CA2743992A1 (en) 2008-11-17 2010-05-20 Minnow Medical, Inc. Selective accumulation of energy with or without knowledge of tissue topography
CN102307618B (zh) 2008-12-09 2014-03-12 内费拉有限公司 泌尿系统的刺激
WO2010082993A2 (en) 2008-12-11 2010-07-22 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
US20100160903A1 (en) 2008-12-22 2010-06-24 Yosef Krespi Process and system for treating a vascular occlusion or other endoluminal structure
US20100160906A1 (en) 2008-12-23 2010-06-24 Asthmatx, Inc. Expandable energy delivery devices having flexible conductive elements and associated systems and methods
US8317810B2 (en) 2008-12-29 2012-11-27 St. Jude Medical, Atrial Fibrillation Division, Inc. Tissue puncture assemblies and methods for puncturing tissue
US9352174B2 (en) 2008-12-30 2016-05-31 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation system with blood leakage minimization and tissue protective capabilities
US20100168739A1 (en) 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8808345B2 (en) 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
EP2208506A1 (en) 2009-01-16 2010-07-21 Oncotherm Kft. Intraluminar oncothermia catheter
WO2010088301A1 (en) 2009-01-27 2010-08-05 Boveda Marco Medical Llc Catheters and methods for performing electrophysiological interventions
EP2404171A4 (en) 2009-03-03 2016-01-27 Mc10 Inc SYSTEMS, METHODS AND DEVICES HAVING INTEGRATED INTEGRATED CIRCUIT ELEMENTS FOR DETECTING AND ADMINISTERING THERAPY
US20100249604A1 (en) 2009-03-31 2010-09-30 Boston Scientific Corporation Systems and methods for making and using a motor distally-positioned within a catheter of an intravascular ultrasound imaging system
US8287532B2 (en) 2009-04-13 2012-10-16 Biosense Webster, Inc. Epicardial mapping and ablation catheter
EP2421536B1 (en) 2009-04-20 2015-08-26 Gilead Calistoga LLC Methods of treatment for solid tumors
US8399443B2 (en) 2009-04-22 2013-03-19 Mercator Medsystems, Inc. Treatment of hypertension by renal vascular delivery of guanethidine
US8517955B2 (en) 2009-05-08 2013-08-27 Broncus Medical Inc. Tissue sampling devices, systems and methods
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US8292881B2 (en) 2009-05-27 2012-10-23 Vivant Medical, Inc. Narrow gauge high strength choked wet tip microwave ablation antenna
ES2717268T3 (es) 2009-07-08 2019-06-20 Sanuwave Inc Uso de ondas de choque de presión intracorpóreas en medicina
WO2011005901A2 (en) 2009-07-09 2011-01-13 Silhouette Medical Inc. Apparatus for treating medical conditions of hollow anatomical structures
US20110071400A1 (en) 2009-09-23 2011-03-24 Boston Scientific Scimed, Inc. Systems and methods for making and using intravascular ultrasound imaging systems with sealed imaging cores
US20110071401A1 (en) 2009-09-24 2011-03-24 Boston Scientific Scimed, Inc. Systems and methods for making and using a stepper motor for an intravascular ultrasound imaging system
US8343145B2 (en) 2009-09-28 2013-01-01 Vivant Medical, Inc. Microwave surface ablation using conical probe
US9101733B2 (en) 2009-09-29 2015-08-11 Biosense Webster, Inc. Catheter with biased planar deflection
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
EP3132828B1 (en) 2009-10-30 2017-10-11 ReCor Medical, Inc. Apparatus for treatment of hypertension through percutaneous ultrasound renal denervation
CN102596319B (zh) 2009-10-30 2015-07-15 科纳医药股份有限公司 通过去肾交感神经非侵入性地治疗高血压的装置
US20110112400A1 (en) 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
EP2498706B1 (en) 2009-11-13 2016-04-20 St. Jude Medical, Inc. Assembly of staggered ablation elements
US20110137155A1 (en) 2009-12-09 2011-06-09 Boston Scientific Scimed, Inc. Delivery device for localized delivery of a therapeutic agent
US9179827B2 (en) 2009-12-15 2015-11-10 Boston Scientific Scimed, Inc. Systems and methods for determining the position and orientation of medical devices inserted into a patient
US20110263921A1 (en) 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
US20110270238A1 (en) 2009-12-31 2011-11-03 Raed Rizq Compliant Cryoballoon Apparatus for Denervating Ostia of the Renal Arteries
US20110264116A1 (en) 2009-12-31 2011-10-27 Gordon Kocur Compressive Denervation Apparatus for Innervated Renal Vasculature
US20110200171A1 (en) 2010-01-19 2011-08-18 Ardian, Inc. Methods and apparatus for renal neuromodulation via stereotactic radiotherapy
CA2793737A1 (en) 2010-03-24 2011-09-29 Shifamed Holdings, Llc Intravascular tissue disruption
CN103068330B (zh) 2010-04-09 2016-06-29 Vessix血管股份有限公司 用于治疗组织的功率发生和控制装置
US20110257641A1 (en) 2010-04-14 2011-10-20 Roger Hastings Phototherapy for renal denervation
EP2558016A2 (en) 2010-04-14 2013-02-20 Boston Scientific Scimed, Inc. Renal artery denervation apparatus employing helical shaping arrangement
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US20110257642A1 (en) 2010-04-16 2011-10-20 Griggs Iii Charles Sherman Method for producing a permanent or nearly permanent skin image, design or tattoo by freezing the skin
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US8120518B2 (en) 2010-06-14 2012-02-21 Koren Advanced Institute of Science and Technology Digital feedforward sigma-delta modulator in analog-to-digital converter and modulation method thereof
US9358020B2 (en) 2010-06-25 2016-06-07 Boston Scientific Scimed Inc. Catheter device for delivery energy to a vein
US20120029512A1 (en) 2010-07-30 2012-02-02 Willard Martin R Balloon with surface electrodes and integral cooling for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US20120029505A1 (en) 2010-07-30 2012-02-02 Jenson Mark L Self-Leveling Electrode Sets for Renal Nerve Ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US20120029496A1 (en) 2010-07-30 2012-02-02 Scott Smith Renal nerve ablation using mild freezing and microwave energy
US9463062B2 (en) * 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
CN103547229B (zh) 2010-08-05 2017-09-26 美敦力Af卢森堡有限责任公司 用于肾神经调制的低温消融装置、系统及方法
CN103200893A (zh) 2010-09-07 2013-07-10 波士顿科学西美德公司 用于肾去神经的自供电消融导管
US20120059241A1 (en) 2010-09-08 2012-03-08 Boston Scientific Scimed, Inc. Systems and methods for making and using a steerable imaging system configured and arranged for insertion into a patient
US20120065554A1 (en) 2010-09-09 2012-03-15 Michael Pikus Dual Balloon Ablation Catheter with Vessel Deformation Arrangement for Renal Nerve Ablation
US20120065506A1 (en) 2010-09-10 2012-03-15 Scott Smith Mechanical, Electromechanical, and/or Elastographic Assessment for Renal Nerve Ablation
WO2012054762A2 (en) 2010-10-20 2012-04-26 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable mesh structures for renal neuromodulation and associated systems and methods
US9084610B2 (en) 2010-10-21 2015-07-21 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
TW201221174A (en) 2010-10-25 2012-06-01 Medtronic Ardian Luxembourg Microwave catheter apparatuses, systems, and methods for renal neuromodulation
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
EP3100696B1 (en) 2010-10-25 2023-01-11 Medtronic Ardian Luxembourg S.à.r.l. Catheter apparatuses having multi-electrode arrays for renal neuromodulation
JP6046041B2 (ja) 2010-10-25 2016-12-14 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ 神経変調療法の評価及びフィードバックのためのデバイス、システム、及び方法
US9060755B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US20120109021A1 (en) 2010-10-27 2012-05-03 Roger Hastings Renal denervation catheter employing acoustic wave generator arrangement
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US20120123261A1 (en) 2010-11-16 2012-05-17 Jenson Mark L Renal Nerve Ablation Using Mild Freezing and Vibration
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US20120265198A1 (en) 2010-11-19 2012-10-18 Crow Loren M Renal nerve detection and ablation apparatus and method
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US20120136349A1 (en) 2010-11-30 2012-05-31 Roger Hastings RENAL DENERVATION CATHETER AND METHOD USING pH ALTERATION
US20120157992A1 (en) 2010-12-15 2012-06-21 Scott Smith Off-wall electrode device for renal nerve ablation
US20120232409A1 (en) 2010-12-15 2012-09-13 Stahmann Jeffrey E System and method for renal artery occlusion during renal denervation therapy
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US20120184952A1 (en) 2011-01-19 2012-07-19 Jenson Mark L Low-profile off-wall electrode device for renal nerve ablation
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
CN103813745B (zh) 2011-07-20 2016-06-29 波士顿科学西美德公司 用以可视化、对准和消融神经的经皮装置及方法
CN103813829B (zh) 2011-07-22 2016-05-18 波士顿科学西美德公司 具有可定位于螺旋引导件中的神经调制元件的神经调制系统
US20130035681A1 (en) 2011-08-04 2013-02-07 Boston Scientific Scimed, Inc. Novel catheter for contiguous rf ablation
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
US9427579B2 (en) 2011-09-29 2016-08-30 Pacesetter, Inc. System and method for performing renal denervation verification
US20140243821A1 (en) 2011-09-30 2014-08-28 Covidien Lp Energy delivery device and methods of use
WO2013055826A1 (en) 2011-10-10 2013-04-18 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
WO2013055685A2 (en) 2011-10-10 2013-04-18 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
AU2012321166A1 (en) 2011-10-11 2014-05-08 Boston Scientific Scimed, Inc. Ablation catheter with insulated tip
US20130090649A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
US20130090650A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Renal nerve ablation cooling device and technique
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
US20130096550A1 (en) 2011-10-18 2013-04-18 Boston Scientific Scimed, Inc. Ablative catheter with electrode cooling and related methods of use
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
EP2768568B1 (en) 2011-10-18 2020-05-06 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
US20130110106A1 (en) 2011-10-28 2013-05-02 Boston Scientific Scimed, Inc. Expandable structure for off-wall ablation electrode
CN108095821B (zh) 2011-11-08 2021-05-25 波士顿科学西美德公司 孔部肾神经消融
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
EP2793724B1 (en) 2011-12-23 2016-10-12 Vessix Vascular, Inc. Apparatuses for remodeling tissue of or adjacent to a body passage
CN104135958B (zh) 2011-12-28 2017-05-03 波士顿科学西美德公司 用有聚合物消融元件的新消融导管调变神经的装置和方法
WO2013101446A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Balloon expandable multi-electrode rf ablation catheter
US20130172879A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation medical devices
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US20130172880A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods for renal nerve modulation
CN104135959A (zh) 2011-12-29 2014-11-05 波士顿科学西美德公司 用于肾神经调变监测的装置和方法

Also Published As

Publication number Publication date
US9433760B2 (en) 2016-09-06
US20160331432A1 (en) 2016-11-17
EP2797534A1 (en) 2014-11-05
CN104135958A (zh) 2014-11-05
US20130172872A1 (en) 2013-07-04
US9757177B2 (en) 2017-09-12
WO2013101452A1 (en) 2013-07-04

Similar Documents

Publication Publication Date Title
CN104135958B (zh) 用有聚合物消融元件的新消融导管调变神经的装置和方法
CN106232043B (zh) 具有编织轴的神经调节导管以及相关的系统和方法
AU2010241463B2 (en) Catheter with helical electrode
JP6716249B2 (ja) 多孔質基材及び高密度表面微小電極を有する灌注式先端電極を有するカテーテル
US10660703B2 (en) Renal nerve modulation devices
US10321946B2 (en) Renal nerve modulation devices with weeping RF ablation balloons
CN105636537B (zh) 医疗器械球囊
JP7260572B2 (ja) ルーメンを有する電気外科手術デバイス
US20150018817A1 (en) Multiple electrode conductive balloon
US20150112328A1 (en) Balloon catheters with flexible conducting wires and related methods of use and manufacture
CN105555218B (zh) 具有冲洗和冷却能力的射频(rf)球囊导管
EP3125802A1 (en) Ablation catheter and ablation apparatus
WO2006026210A2 (en) Devices for delivering agents to tissue region while preventing leakage
CN105848603A (zh) 用于调节与肺部系统通信的神经的导管设备以及相关联的系统及方法
CN114206247A (zh) 用于受控体积消融的装置、系统和方法
US20140088586A1 (en) Renal nerve modulation devices
CN103220994A (zh) 具有用于直流电组织治疗的无关电极的电极导管装置

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20170503

Termination date: 20191211