CN104288240A - Antiviral oral liquid and preparation method thereof - Google Patents

Antiviral oral liquid and preparation method thereof Download PDF

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Publication number
CN104288240A
CN104288240A CN201410548338.0A CN201410548338A CN104288240A CN 104288240 A CN104288240 A CN 104288240A CN 201410548338 A CN201410548338 A CN 201410548338A CN 104288240 A CN104288240 A CN 104288240A
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Prior art keywords
oral liquid
radix
preparation
weight
parts
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CN201410548338.0A
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Chinese (zh)
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CN104288240B (en
Inventor
赵万军
秦雪梅
高晓霞
梁琪
石民
吕建旭
田志力
侯耀飞
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SHANXI TIANHEYUAN ANIMAL HEALTH TECHNOLOGY Co Ltd
Shanxi University
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SHANXI TIANHEYUAN ANIMAL HEALTH TECHNOLOGY Co Ltd
Shanxi University
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Priority to CN201410548338.0A priority Critical patent/CN104288240B/en
Publication of CN104288240A publication Critical patent/CN104288240A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides antiviral oral liquid and a preparation method thereof. The Chinese herbal medicine comprises the following raw materials in parts by weight: 1-7 parts of polygonum cuspidatum, 1-4 parts of astragalus, 1-2 parts of isatis root and 1-8 parts of liquorice. The preparation method comprises the following steps: adding water into the Chinese herbal medicine raw materials for decocting according to ratio, filtering, concentrating the filtrate into thick paste, adding a preservative, stirring to be uniform, filling, and sterilizing, thereby obtaining the antiviral oral liquid. The oral liquid can effectively treat viral infectious diseases of beasts and birds and has the advantages of high dissolubility, fast absorption, obvious effect, zero toxic or side effect and low cost.

Description

A kind of antivirus oral liquid and preparation method thereof
Technical field
The present invention relates to Chinese medicine composition, specifically belong to a kind of antivirus oral liquid and preparation method thereof.
Background technology
Animal viral disease is one of infectious disease the most serious to animal injury on veterinary clinic, and particularly some high therapeutic virosiss is popular, carrys out huge loss often to cultivation industrial belt.The virosis of poultry is propagated soon usually, pathogenicity rate and fatality rate high, the health and lives of serious harm poultry, affects Animal husbandry production.
Along with the development of animal husbandry; modernization scientific culture instead of old-fashioned traditional method; raise family scattered and become scale livestock farming; therefore; how to improve Prevention Technique; ensureing that livestock birds health growth is with the attention causing people, not only rests on the disease for the treatment of poultry in the modern times to the use of medicine, is more the resistance against diseases strengthening poultry body for prevention and health care.According to statistics, original pharmaceutical antibiotics class medicine accounts for over half, antiviral drugs conventional clinically has ribavirin, acyclovir, amantadine etc., but because these are all the medicines that people and animals share, drug residue is had to animal products after poultry long-term prescription thing, this series products of mankind's life-time service also can cause corresponding harm, has all been listed in forbidding medicine in present veterinary drug.
Along with people are to the drug resistance of western medicine antibiotics and the understanding in situations such as poultry body accumulations, the research of antiviral natural medicine comes into one's own day by day, but some Chinese herbal medicine not only has viricidal effect, and can regulate the immunologic function of body, has nonspecific antiviral functions.The advantages such as in addition, it is little that Chinese herbal medicine has toxic and side effects, aboundresources, cheap.
Summary of the invention
The object of this invention is to provide a kind of antivirus oral liquid and preparation method thereof, this oral liquid can effectively treat livestock and poultry virus sexually transmitted disease, and have dissolubility good, absorb fast, successful, have no side effect, the advantage such as with low cost.
A kind of antivirus oral liquid provided by the invention, medicinal raw material is counted by weight and is comprised: Rhizoma Polygoni Cuspidati 1-7, Radix Astragali 1-4, Radix Isatidis 1-2, Radix Glycyrrhizae 1-8.
Preferred weight number proportioning comprises: Rhizoma Polygoni Cuspidati 3-7, Radix Astragali 2-4, Radix Isatidis 1-2, Radix Glycyrrhizae 3-8.
The preparation method of a kind of antivirus oral liquid provided by the invention, comprises the steps: to take Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Isatidis, Radix Glycyrrhizae by above-mentioned medicinal raw material weight proportion; Pulverize, mixing, add 6-10 water doubly by medical material weight, decoct and extract 2-3 time, each 1-2h, merge extractive liquid, filter, filtrate is concentrated into the thick paste that density is 1.00-1.06, adds benzoic acid and each 0.1-0.5% of ethyl hydroxybenzoate by thick paste weight, stir evenly, fill, sterilizing, to obtain final product.
Antivirus oral liquid of the present invention, has effect of strengthening vital QI to eliminate pathogenic factors, invigorating qi and benefiting blood, invigorate blood circulation the Eradicates stasis of blood, heat-clearing and toxic substances removing, relieving cough and relieving asthma, can enhancing human body immunity power.Can be used for warm epidemic disease poison epizootic modeling, animal body constitution declines, infect epidemic disease poison, heating, dry cough and to breathe heavily spirit depressed, appetite declines, the diseases caused by exogenous pathogenic factor seasonal pathogen such as yellow fur, dispute are red, stool Huang is smelly, inside have hot and suffocating card.
Antivirus oral liquid of the present invention can effectively treat livestock and poultry virus sexually transmitted disease, and its dissolubility is good, it is fast to absorb, successful, have no side effect, and the advantage such as it is simple to have preparation method, with low cost.It can apply in preparation treatment animal particularly animal viral infectious disease drugs.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further.
Embodiment 1
Antivirus oral liquid formula: Rhizoma Polygoni Cuspidati 1500g, Radix Astragali 1000g, Radix Isatidis 500g, Radix Glycyrrhizae 1500g.
Preparation method: get Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Isatidis, Radix Glycyrrhizae by proportioning, pulverizes, and mixing, adds the water of 36 liters, decoct 2 times, each 1.5h, merge extractive liquid, filter, filtrate is concentrated into the thick paste that density is 1.02, adds benzoic acid and ethyl hydroxybenzoate each 0.3%, stir evenly, fill, sterilizing, obtain oral liquid.
Embodiment 2
Antivirus oral liquid formula: Rhizoma Polygoni Cuspidati 1200g, Radix Astragali 1200g, Radix Isatidis 800g, Radix Glycyrrhizae 1600g.
Preparation method: get Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Isatidis, Radix Glycyrrhizae by proportioning, pulverizes, and mixing, adds the water of 36 liters, decoct 3 times, each 1h, merge extractive liquid, filter, filtrate is concentrated into the thick paste that density is 1.04, adds benzoic acid and ethyl hydroxybenzoate each 0.3%, stir evenly, fill, sterilizing, obtain oral liquid.
Embodiment 3
Antivirus oral liquid formula: Rhizoma Polygoni Cuspidati 1750g, Radix Astragali 1000g, Radix Isatidis 250g, Radix Glycyrrhizae 2000g.
Preparation method is with embodiment 1.
Embodiment 2 clinical trial I
(1) experimental animal:
In May, 2014, Simmental 60 bull is supported by plant of Xinzhou Shanxi, and weight average is at about 350 jin.Just find that indivedual cattle occurs that spirit is depressed from early May, few food, does not ruminate, and stool is yellow and smelly, and oliguria, rapid breathing, cough, breathes, high fever, and this is sick to find again many cases cattle infected at treatments period, has the gesture of infection.
(2) diagnose
Contagious pleuropneumonia is diagnosed as according to epidemic.
(3) therapeutic scheme
Morbidity cattle, this product every 200mL gavages, one day twice, is used in conjunction two days.
Jumpbogroup, on average every 150mL drinking-water is used in conjunction two days
(4) therapeutic outcome
3rd, sick cattle temperature recovery was normal, and cough with asthma stops, and start to ruminate, spirit is clearly better, and starts to search for food, but does not return to normal amount.This product every 150mL uses 3 days again.Call-on back by phone after one week, the whole rehabilitation of the ill cattle of institute, other cattle do not occur infecting phenomenon more yet.
Embodiment 3 clinical trial II
(1) experimental animal:
In August, 2014, Shanxi cultivates company from stone, supports AA+ broiler 100,000, from changing No. 3 material, feed intake day by day declines, and starts to occur fragmentary death, to 38 ages in days, dead about 210 of day, feed intake and standard volume diurnal inequality 4000 jin, jumpbogroup shows as depressed, the loose unrest of feather of spirit, swollen face is shed tears, analyse glandular stomach diffuse hemorrhage, liver surface adularescent peplos, duodenum Semen Jujubae sample ulcer, rectum band shape is hemorrhage, draws yellow green thickness sample feces.
(2) diagnose
Be atypical newcastle disease and escherichia coli mixed infection after diagnosing.
(3) therapeutic scheme
600 chickens gavage this product (0.5ml/ kilogram), are used in conjunction 3 days.
(4) therapeutic outcome
Feed intake bottom out in second day after medication, dead quantity drops to about 130, and spirit is clearly better.Search for food after three days and recover normal, dead quantity is 62.Feces recovers normal.

Claims (4)

1. an antivirus oral liquid, is characterized in that, medicinal raw material is counted by weight and comprised: Rhizoma Polygoni Cuspidati 1-7, Radix Astragali 1-4, Radix Isatidis 1-2, Radix Glycyrrhizae 1-8.
2. a kind of antivirus oral liquid as claimed in claim 1, is characterized in that, medicinal raw material is counted by weight and comprised: Rhizoma Polygoni Cuspidati 3-7, Radix Astragali 2-4, Radix Isatidis 1-2, Radix Glycyrrhizae 3-8.
3. a preparation method for antivirus oral liquid, comprises the steps: to take Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Isatidis, Radix Glycyrrhizae by the weight proportion of medicinal raw material described in claim 1 or 2, pulverizes, mixing, adds 6-10 water doubly by medical material weight, decocts and extract 2-3 time, each 1-2h, merge extractive liquid, filters, filtrate is concentrated into the thick paste that density is 1.00-1.06, add benzoic acid and each 0.1-0.5% of ethyl hydroxybenzoate by thick paste weight, stir evenly, fill, sterilizing, to obtain final product.
4. the application of antivirus oral liquid as claimed in claim 1 or 2 in preparation treatment animal viral infectious disease drugs.
CN201410548338.0A 2014-10-16 2014-10-16 A kind of antiviral oral liquor and preparation method thereof Expired - Fee Related CN104288240B (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886666A (en) * 1987-01-27 1989-12-12 Yaguang Liu Pharmaceutical composition for inhibiting viruses and increasing immune function (PII)
CN101085048A (en) * 2006-06-06 2007-12-12 河南农业大学 Traditional Chinese medicine for detoxicating for animals and preparation method thereof
CN101108203A (en) * 2006-03-27 2008-01-23 姜宝库 Radix astragali particle for preventing cold

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886666A (en) * 1987-01-27 1989-12-12 Yaguang Liu Pharmaceutical composition for inhibiting viruses and increasing immune function (PII)
CN101108203A (en) * 2006-03-27 2008-01-23 姜宝库 Radix astragali particle for preventing cold
CN101085048A (en) * 2006-06-06 2007-12-12 河南农业大学 Traditional Chinese medicine for detoxicating for animals and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
樊慧婷等: "中药虎杖的药理研究进展", 《中国中药杂志》 *

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