CN104382636A - Device for repairing fractured bones and method for manufacturing device - Google Patents
Device for repairing fractured bones and method for manufacturing device Download PDFInfo
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- CN104382636A CN104382636A CN201410746297.6A CN201410746297A CN104382636A CN 104382636 A CN104382636 A CN 104382636A CN 201410746297 A CN201410746297 A CN 201410746297A CN 104382636 A CN104382636 A CN 104382636A
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- inner sleeve
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- connecting rod
- outer sleeve
- bone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00836—Material properties corrosion-resistant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B2017/564—Methods for bone or joint treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
Abstract
The invention discloses a device for repairing fractured bones and a method for manufacturing the device. The device comprises an outer sleeve, an inner sleeve and a connecting rod. The inner diameter of the outer sleeve is matched with the outer diameters of two ends of a tubular bone defect position with bone grafting requirements, the inner sleeve is positioned in the outer sleeve, the outer sleeve is longer than the inner sleeve, the connecting rod is inserted in the inner sleeve, the diameter of the connecting rod is basically identical to the inner diameter of the inner sleeve so that the inner sleeve can be clamped by the connecting rod, and the connecting rod is longer than the inner sleeve by 0.5-2cm. The inner sleeve and the outer sleeve are made of biodegradable magnesium alloy, and degradable high-polymer films with biocompatibility when in human bodies cover the surfaces of the inner sleeve and the outer sleeve. The device and the method have the advantage that the device is excellent in strength and biocompatibility.
Description
Technical field
The present invention relates to a kind of device for repair of bone fractures (comprising bone defect) skeleton and manufacture method thereof, particularly relate to and use special substance and Bone Defect Repari medium.
Technical background
Union of fracture refers to the process of tissue repair between fracture site, and its final result is that the osseous tissue of damage recovers normal structure and biomechanical function, wherein makes the end of fractured bone carry out rejoining and again aiming at.When needing normal position and the function recovering fractured bone, just need to carry out fracture repair.In the whole process in union of fracture stage, skeleton must to be firmly held on correct position and to support, until it is enough strong in taking the weight of.When not rightly repair of bone fractures, likely there is the dislocation of skeleton, thus cause the possible body function obstacle in skeleton or that joint, region of health.
Former, main mould and the clamping plate of relying on are from external support skeleton.But the development of aseptic operation reduces the risk of infection, therefore doctor can directly process skeleton, and material can be implanted.It comprises use internal fixing device, and such as steel wire, plate, rod, pin, nail and screw directly support skeleton, and bone cement mixture or bone void filler is added in fractured bones.
Fracture because defect disunion is orthopaedics common disease, the treatment of nonunion is one of orthopedist's facing challenges.The disunion caused because of defect for fracture has multiple therapy methods, wherein bone grafting be commonly use the most, the good Therapeutic Method of effect.Bone grafting method at present for tubular bone adopts external fixer bone grafting, and external fixer two ends are fixedly connected with the two ends at tubular bone defect place, and place the fibula intercepted at the defect place of tubular bone, fibula is fastening by external fixer.The shortcoming of this method does not have intramedullary pin to be connected between fibula and the tubular bone at two ends, and bone grafting is very thin, intensity is little, limitation of activity when not healing.In addition, partial fracture disunion application bone grafting treats still disunion, needs secondary bone grafting operation, and application simultaneously promotes the various biological son that fracture repair mechanism starts again, such as bone morphogenetic protein.Such drug price is expensive, and some cases therapeutic effect is imprecise.
CN102389329A discloses a kind of more for the bone grafting device of tubular bone defect healing, and it comprises inside and outside sleeve and connecting rod.But in this patent documentation, the material of sleeve is general degradable magnesium alloy, is difficult to take into account biocompatibility and mechanical strength, and the autologous spongiosa bone adopted in addition is common spongy bone, and prosthetic is undesirable.By reference whole disclosures of this patent are incorporated to herein.
CN1761433A discloses the repair apparatus that a kind of the past tiltedly just inserts intervertebral site, comprise first element with the first flange engaged front oblique side with the first vertebrae, first flange is relative to the transverse axis of the first element and longitudinal axis bevel, with second element with the second flange engaged front oblique side with the second vertebrae, second flange is relative to the transverse axis of the second element and longitudinal axis bevel, wherein the first and second combination of elements together, can make to form joint motions between the first and second elements.
US4502161A discloses and uses rustless steel wire harness therein, silicone rubber, rubber or politef meniscal repairs body that nylon or woven fabric strengthen.The material proposed has lower biocompatibility and likely causes the reaction of serious synovial fluid.
WO89/00413A1 discloses the meniscus of the reparation be made up of the cubical array of collagen-type I fiber, and this collagen-type I fiber is by being polymerized aminopolysaccharide molecular composition and interconnecting via being cross-linked.In vivo, substrate has the outer surface profile substantially the same with born meniscus.Substrate provides part resorbently can be suitable for the ingrown shelf of meniscal fibrocartilage cells.Although its structure can have the shape and size determined, but its mechanical performance-particularly modulus of compressibility-can not close to the mechanical performance of cartilage.
US4919667A discloses a kind of meniscal repairs body by polyester and polyurethanes combined structure.This mylar is set to the felt of multilamellar, and wherein the intermediate layer of one deck or more is clipped in also is between the woven cloth top layer of polyester and bottom.This polyester and polyurethanes probably have better biocompatibility compared with the material reported in US4502161A.
Using fixture and being added to by bone cement (Bone Defect Repari medium) in fractured bones for repairing skeleton is prior art is well-known.But, traditional bone cement biocompatibility and biomechanical property poor, material-osseous tissue interface is also poor, and fixture also has poor biological degradability and the balance of intensity.This area needs a kind of fixture with good biological degradability and intensity and bone cement.
Summary of the invention
For solving the above-mentioned problems in the prior art, on the basis of existing technology, the present inventor, through further investigation and great many of experiments, proposes following technical scheme:
On the one hand, the invention provides a kind of device for repair of bone fractures (comprising bone defect) skeleton, it is characterized in that, this device comprises outer sleeve, inner sleeve and connecting rod, the internal diameter of outer sleeve matches with the external diameter at the two ends needing the tubular bone defect place of bone grafting, inner sleeve is positioned at outer sleeve, the length of outer sleeve is greater than the length of inner sleeve, connecting rod is inserted in inner sleeve, the diameter of connecting rod is substantially identical with the internal diameter of inner sleeve, connecting rod is made to clamp inner sleeve, the length 0.5-2cm larger than the length of inner sleeve of connecting rod.
Preferably, described inner sleeve simply footpath is 3mm-3.5cm, and overcoat simply footpath is 4mm-5cm, and length is 2-15cm.
Preferably, the wall thickness of described inner sleeve (3) is 0.2-1mm, and the wall thickness of outer sleeve (2) is 0.3-0.8mm.
Most preferably, described inner sleeve and outer sleeve are made up of degradable magnesium alloy, preferred described connecting rod is also made up of degradable magnesium alloy, described magnesium alloy is biological medical magnesium alloy, its component and mass percentage as follows: Sn 1.0-3.0%, Zn 0.6-0.8%, Mn 0.20-0.50%, Ca 0.10-0.50%, Nd 0.01-0.20%, Impurity Fe < 0.001%, Cu < 0.001% and Ni < 0.002%, surplus is Mg.
In this magnesium alloy Nd add and the selection of certain content significantly can weaken galvanic corrosion tendency, greatly put forward heavy alloyed corrosion resistance, the present inventor finds after further research, and its corrosion rate is 46% of corrosion rate when not adding Nd.In addition, Ca adds the corrosion resistance significantly strengthening magnesium alloy, and its superficial film membrane resistance increases up to 4 times.These effects are all that those skilled in the art institute is unforeseeable.
Described magnesium alloy obtains by the following method:
(1) according to above-mentioned mass percent, adopt pure magnesium ingot, pure tin ingot, pure zinc ingot, calcium oxide, neodymium silk and Mg-Mn intermediate alloy under flux protection, carry out melting, magnesium alloy ingot is made in casting;
(2) carry out multi-pass rolling predeformation after magnesium alloy ingot being kept 3-5 hour at 300 DEG C-400 DEG C, every time predeformation amount is less than 5%;
(3) magnesium alloy after predeformation is carried out solution heat treatment, solid solution temperature is 455 DEG C-500 DEG C, and the solution treatment time is 3-10 hour, and the cold or air cooling of then shrend, stove is to room temperature;
(4) step (3) is obtained product and carry out Ageing Treatment, first at 400-440 DEG C of solution treatment 1-6 hour, shrend to room temperature, then timeliness 16-24 hour first at 80-100 DEG C, timeliness 6-24 hour again at 160-200 DEG C subsequently, air cooling is to room temperature.
The present inventor finds after deliberation, adding of the manganese of specified quantitative, bone growth and development can be promoted, keep normal brain function, normal sugar, lipid metabolism can also be maintained, improve the hemopoietic function of body, endocrine function can also be strengthened, maintain thyroid normal function, promote the synthesis of gonadal hormone, regulate nerves reaction ability.In addition, magnesium alloy stacking fault energy of the present invention is lower, the stacking fault energy of material is lower more easily produces growth twin, the alloy elements such as Sn, Zn and Mn add the stacking fault energy that reduce further alloy, alloy is made to be easy to form raised growth twin in solution heat treatment process, and when less deflection makes formed dislocation structure be distributed in matrix equably, be conducive to being formed very tiny twin.
The described magnesium alloy obtained by the inventive method, after solution treatment, produces raised growth twin.In crystal grain, the existence of a large amount of tiny twin improves the obdurability of this alloy effectively, there is good comprehensive mechanical property, after tested, under described magnesium alloy room temperature of the present invention, tensile strength is 220MPa, percentage elongation is 25%%, and have lower hemolysis rate in addition, hemolysis rate is only 3.12%, meet the requirement of biomaterial hemolysis rate completely, be particularly suitable for being used as biodegradability fracture repair backing material.
In a preferred enforcement, the barrel of described inner sleeve and outer sleeve is the meshed network structure of tool.
Preferably Bone Defect Repari medium is filled between inner sleeve and outer sleeve.
Described Bone Defect Repari medium can be modified hydroxylapatite granule, and its particle diameter is 10-50nm.The New born formation speed of this Bone Defect Repari medium is more than 2 times of common commercially available spongy bone.
Described modified hydroxylapatite granule is the polymer of compound (i.e. monomer) and the complex of hydroxyapatite shown in following formula (I):
The polymerization process of described polymer is as follows:
Taking compound shown in a certain amount of formula (I) loads in three-neck flask, then the toluene solution containing stannous octoate is injected, shown in formula (I), the mol ratio of compound and stannous octoate is 2000: 1 to 3000: 1, then evacuation, by flask pressure drop to below 0.5Pa, be polymerized at 70-90 DEG C of temperature afterwards, polymerase 10 .5-3 hour, obtain polymer powder.
In methanol solvate, by described polymer powder and hydroapatite particles with 1: 3-1: 6 weight ratio mix, then filter, dry, pulverize, sieve, getting particle diameter is that 10-50nm part is as required modified hydroxylapatite granule.
Additionally, the surface of described inner sleeve and outer sleeve is covered with the degradable high polymer film in human body with biocompatibility.This high-polymer membrane is prepared by the following method:
Take a certain amount of PHBV and poly-succinic fourth diester, wherein the weight ratio of PHBV and poly-succinic fourth diester is 1: 5-2: 1 (preferably 1: 1), the mixture of the two is dissolved in the chloroformic solution of 30-60 DEG C, stir and heating in water bath 1-10 hour, standing and defoaming, then brushing is adopted, spraying, dip-coating and the tape casting are coated in the surface of inner sleeve and outer sleeve, inner sleeve through applying and outer sleeve are placed 8-15 hour as in vacuum drying oven in 50-80 DEG C, thus at inner sleeve, outer sleeve surface forms blend film, the thickness controlling thin film is 0.01-0.2mm, then with described in the Ammonia process of 1-3mol/L thin film 2-5 hour to activate its surface, then rinse well with deionization, vacuum drying 6-10 hour under 50-80 again, get product.
The applying of described degradable high polymer film drastically increases the biocompatibility of degradable magnesium alloy, makes it have and applies widely.
On the other hand, provide a kind of method manufacturing said apparatus, described device comprises outer sleeve, inner sleeve and connecting rod, the internal diameter making outer sleeve matches with the external diameter at the two ends at the tubular bone defect place needing bone grafting, and inner sleeve is positioned at outer sleeve, and the length of outer sleeve is greater than the length of inner sleeve, connecting rod is inserted in inner sleeve, the diameter of connecting rod is substantially identical with the internal diameter of inner sleeve, makes connecting rod to clamp inner sleeve, the length 0.5-2cm larger than the length of inner sleeve of connecting rod.
Preferably, to filling Bone Defect Repari medium between inner sleeve and outer sleeve.
Accompanying drawing explanation
Fig. 1 is the structural representation according to the device for repair of bone fractures skeleton of the present invention.
Fig. 2 is the using state figure according to the device for repair of bone fractures skeleton of the present invention.
Detailed description of the invention:
Embodiment 1
As shown in Figure 1, the described device for repair of bone fractures skeleton is made up of outer sleeve 2, inner sleeve 3, connecting rod 4.The two ends of outer sleeve 2 are enclosed within the two ends at the tubular bone defect place needing bone grafting, and are fixed by screw 5.Inner sleeve 3 is positioned at outer sleeve 2, and connecting rod 4 is inserted in inner sleeve 3, and the diameter of connecting rod 4 and the internal diameter of inner sleeve 3 match, and the two ends of connecting rod 4 are inserted in the pulp cavity of tubular bone 1.Connecting rod 4 is shaft-like or column structure, generally can adopt intramedullary pin.The barrel of inner sleeve and outer sleeve is the network structure having mesh, and inner sleeve and outer sleeve are made by degradable magnesium alloy, and degradable magnesium alloy material, except bone grafting, the effect of enhancing stability maintenance, also has induction osteogenesis effect, thus promotes union of fracture.Inner sleeve 3 diameter is 3mm-3.5cm, and outer sleeve 2 diameter is 4mm-5cm, and length is 2-15cm.
Embodiment 2
As shown in Figure 1, the using method of the device of embodiment 1 is as follows: first autologous patient high-quality spongy bone is inserted the space between outer sleeve 2 and inner sleeve 3; Pulled open to two ends by the tubular bone 1 of defect, outer sleeve 2, inner sleeve 3 are placed on tubular bone 1 defect location, and the two ends of inner sleeve 3 are relative with the center, two ends of tubular bone 1 again; Then by the tubular bone 1 of defect to justified, make the two ends of outer sleeve 2 be enclosed within the tubular bone 1 at two ends; Squeeze into connecting rod 4 from one end of tubular bone 1 along pulp cavity, generally adopt intramedullary pin, intramedullary pin passes from inner sleeve 3, enters the pulp cavity of the bottom of tubular bone 1, is firmly coupled together by two sections of tubular bones 1; Finally with screw 5, outer sleeve 2 and tubular bone 1 are fastenedly connected, between inner sleeve 3 and trocar sheath 2, fill Bone Defect Repari medium 6 (i.e. bone grafting).
The open the present invention of this written description use-case, comprises optimal mode, and also enables those skilled in the art manufacture and use the present invention.Of the present inventionly the scope of granted patent can be defined by the claims, and other example that those skilled in the art expect can be comprised.If other example this has the structural element of the literal language not differing from claims, if or other example this comprises and the equivalent structure element of the literal language of claims without substantial differences, then other example this is intended to be within the scope of claims.Can not cause under inconsistent degree, be incorporated herein by reference to by all references part of reference herein.
Claims (10)
1. the device for repair of bone fractures skeleton, it is characterized in that, this device comprises outer sleeve (2), inner sleeve (3) and connecting rod (4), the internal diameter of outer sleeve (2) matches with the external diameter at the two ends needing the tubular bone of bone grafting (1) defect place, inner sleeve (3) is positioned at outer sleeve (2), the length of outer sleeve (2) is greater than the length of inner sleeve (3), connecting rod (4) is inserted in inner sleeve (3), the diameter of connecting rod (4) is substantially identical with the internal diameter of inner sleeve (3), connecting rod is made to clamp inner sleeve, the length 0.5-2cm larger than the length of inner sleeve (3) of connecting rod (4).
2. device according to claim 1, is characterized in that, the diameter of described inner sleeve (3) is 3mm-3.5cm, and length is 1-10cm; The diameter of outer sleeve (2) is 4mm-5cm, and length is 2-15cm.
3. device according to claim 1 and 2, is characterized in that, the wall thickness of described inner sleeve (3) is 0.2-1mm, and the wall thickness of outer sleeve (2) is 0.3-0.8mm.
4. the device according to any one of claim 1-3, is characterized in that, described inner sleeve (3) and outer sleeve (2) are made up of the degradable magnesium alloy that biocompatibility is good.
5. the device according to any one of claim 1-3, is characterized in that, the barrel of described inner sleeve (3) and outer sleeve (2) is the meshed network structure of tool.
6. the device any one of aforementioned claim, is characterized in that, fills Bone Defect Repari medium between inner sleeve and outer sleeve.
7. the device any one of aforementioned claim, wherein said Bone Defect Repari medium is modified hydroxylapatite granule, and its particle diameter is 10-50nm.
8. the device any one of aforementioned claim, the surface of wherein said inner sleeve and outer sleeve is covered with the degradable high polymer film in human body with biocompatibility.
9. one kind manufactures the method for device as claimed in one of claims 1-8, comprise and use outer sleeve (2), inner sleeve (3), connecting rod (4) forms described device, the internal diameter of outer sleeve (2) is matched with the external diameter at the two ends needing the tubular bone of bone grafting (1) defect place, inner sleeve (3) is positioned at outer sleeve (2), the length of outer sleeve (2) is greater than the length of inner sleeve (3), connecting rod (4) is inserted in inner sleeve (3), the diameter of connecting rod (4) is substantially identical with the internal diameter of inner sleeve (3), connecting rod is made to clamp inner sleeve, the length 0.5-2cm larger than the length of inner sleeve (3) of connecting rod (4).
10. method according to claim 9, is characterized in that, fills Bone Defect Repari medium between inner sleeve (3) and outer sleeve (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410746297.6A CN104382636B (en) | 2014-12-10 | 2014-12-10 | Device for repairing fractured bones and method for manufacturing device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410746297.6A CN104382636B (en) | 2014-12-10 | 2014-12-10 | Device for repairing fractured bones and method for manufacturing device |
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| CN104382636A true CN104382636A (en) | 2015-03-04 |
| CN104382636B CN104382636B (en) | 2017-02-15 |
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| CN201410746297.6A Expired - Fee Related CN104382636B (en) | 2014-12-10 | 2014-12-10 | Device for repairing fractured bones and method for manufacturing device |
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| CN105662655A (en) * | 2016-03-16 | 2016-06-15 | 张黎 | Hand and foot bone defect implant |
| CN108158697A (en) * | 2017-12-25 | 2018-06-15 | 中国人民解放军第四军医大学 | bone defect filling bracket structure |
| CN108158696A (en) * | 2017-12-25 | 2018-06-15 | 中国人民解放军第四军医大学 | bone defect filling bracket structure |
| CN108697506A (en) * | 2016-02-16 | 2018-10-23 | 德普伊新特斯产品公司 | Bone graft retainer |
| US10507110B2 (en) | 2016-06-13 | 2019-12-17 | DePuy Synthes Products, Inc. | Bone graft cage |
| US11504240B2 (en) | 2020-06-04 | 2022-11-22 | DePuy Synthes Products, Inc. | Modular bone graft cage |
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| CN108697506A (en) * | 2016-02-16 | 2018-10-23 | 德普伊新特斯产品公司 | Bone graft retainer |
| US10695181B2 (en) | 2016-02-16 | 2020-06-30 | DePuy Synthes Products, Inc. | Bone graft cage |
| CN105662655A (en) * | 2016-03-16 | 2016-06-15 | 张黎 | Hand and foot bone defect implant |
| US10507110B2 (en) | 2016-06-13 | 2019-12-17 | DePuy Synthes Products, Inc. | Bone graft cage |
| US11051944B2 (en) | 2016-06-13 | 2021-07-06 | DePuy Synthes Products, Inc. | Bone graft cage |
| CN108158697A (en) * | 2017-12-25 | 2018-06-15 | 中国人民解放军第四军医大学 | bone defect filling bracket structure |
| CN108158696A (en) * | 2017-12-25 | 2018-06-15 | 中国人民解放军第四军医大学 | bone defect filling bracket structure |
| US11504240B2 (en) | 2020-06-04 | 2022-11-22 | DePuy Synthes Products, Inc. | Modular bone graft cage |
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| CN104382636B (en) | 2017-02-15 |
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