CN104434291A - Functional anti-looseness absorbable screw used in orthopaedics department - Google Patents
Functional anti-looseness absorbable screw used in orthopaedics department Download PDFInfo
- Publication number
- CN104434291A CN104434291A CN201410812257.7A CN201410812257A CN104434291A CN 104434291 A CN104434291 A CN 104434291A CN 201410812257 A CN201410812257 A CN 201410812257A CN 104434291 A CN104434291 A CN 104434291A
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- CN
- China
- Prior art keywords
- screw
- functional anti
- orthopaedics
- bioabsorbable
- looseness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/866—Material or manufacture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/121—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L31/123—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
Abstract
The invention provides a functional anti-looseness absorbable screw used in the orthopaedics department. The screw comprises a screw body and a screw sleeve arranged on the screw body in a sleeving mode, wherein the screw sleeve is made from an absorbable material. The screw has the advantages that certain mechanical binding force exists between the screw sleeve and the screw body, and therefore disengagement does not occur easily during fixation; furthermore, complete degradation can be achieved during inductive formation of new bones after the screw is implanted into the body, acid metabolites are not generated, and bone gomphosis is achieved, so that the early-stage biological stability of the screw is higher and screw looseness frequently caused after an operation is prevented. A biomechanical test proves that the screw sleeve is high in withdrawal force resistance and twisting force resistance. The screw sleeve is wide is application range and has high clinical application value.
Description
Technical field
The present invention relates to the technical field of medical apparatus and instruments, refer more particularly to a kind of functional anti-loosening orthopaedics bioabsorbable interference screw.
Background technology
The damage that during fracture, the mankind are common, refers to a kind of disease because the reason such as wound or pathology causes bone parts or ruptures completely.In current Fracture internal fixaiion treatment, for the patient of fracture, be expert at open reduction and steel plate screw internal fixtion time, the screw used clinically at present can not meet the requirement of fixing all sclerites sometimes, especially for the patient of osteoporotic fracture or comminuted fracture, the screw that happens occasionally is fixed insecure, affect intensity and the effect of internal fixtion, the failure of internal fixation operation may be caused, some patients generation union of fracture is caused to postpone, malunion or bone does not connect, cause suffering limb long pain
A kind of efficient nanofiber technology of preparing of electrostatic textile technology, its principle applies high-pressure electrostatic being equipped with between the shower nozzle of polymer solution and receiving system, solution is made to produce the electric field force contrary with surface tension under high voltage electric field effect, order about solution and be drawn into a taylor cone at shower nozzle end, when electric field force is enough large, taylor cone place drop can overcome surface tension and produce injection stream, in shaking at a high speed, injection stream is by rapid drawing-down, solvent also volatilizees fast, the superfine fibre of micron diameter is received in final formation, the material of any solubilized or melting all can carry out electrospinning processing in theory.Electrospinning fibre diameter usually between tens nanometer between several microns, the tridimensional network that there is great specific surface area, high porosity and be interconnected.
Simultaneously in Bone Defect Repari, rhBMP-2 (rhBMP-2) has osteogenic induction effect.Adopt electrospinning, utilize biopolymer absorbable material, BMP is dissolved in the middle of material, be prepared into the film of activity stabilized, long-time slow release.But rhBMP-is made in the existing report of slow releasing agent, the envelop rate of slow releasing agent is low, is generally 84%, and its slow release effect does not reach the pathology demand of patient yet.In addition, introduce tissue regenerative activity because of sublayer on bone screw surface by coating way, but due to the friction in screw screw-in process, tissue regenerative activity factor coating is easy to come off, is difficult to the effect playing the release of timing localization.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, providing a kind of functional anti-loosening orthopaedics bioabsorbable interference screw.
The present invention is realized by above technical scheme:
The invention provides a kind of functional anti-loosening orthopaedics bioabsorbable interference screw, this functional anti-loosening orthopaedics bioabsorbable interference screw comprises: screw and the screw cover be sleeved on described screw, wherein, and the screw cover that described screw cover is made for bioabsorbable material.
Preferably, the screw cover that described bioabsorbable material is made is that polyhydroxyalkanoate composite hydroxylapatite is configured to solution, utilizes electrostatic textile technology, under high voltage electric field, is nano level three-dimensional shell-like by material weaving.
Preferably, the screw cover that described bioabsorbable material is made is in the solution of polyhydroxyalkanoate composite hydroxylapatite, add a kind of rhBMP-2 (rhBMP-2), utilizing electrostatic textile technology, under high voltage electric field, is nano level three-dimensional shell-like by material weaving.
Preferably, described screw cover wraps described screw entirety.
The invention has the beneficial effects as follows: between functional type Absorbable rod orthopaedic screw cover and screw body, there is certain mechanical bonding force, be not easy time fixing to strip off, and after implanting induce newborn osteogenetic while material is spontaneous can be degradable, do not produce acidic metabolite, form bone packing interaction, make screw have better early stage biological stability, prevent postoperative common screw loosening problem; By Biomechanics test, functional type Absorbable rod orthopaedic screw cover of the present invention has good resisting pull out forces and anti-back-out torsion; Screw cover of the present invention is applied widely, has good clinical value.
Accompanying drawing explanation
Fig. 1 is the structural representation of the functional anti-loosening orthopaedics bioabsorbable interference screw that the embodiment of the present invention provides.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Refer to Fig. 1, Fig. 1 is the structural representation of functional anti-loosening orthopaedics bioabsorbable interference screw provided by the invention.
Embodiments provide a kind of functional anti-loosening orthopaedics bioabsorbable interference screw, this functional anti-loosening orthopaedics bioabsorbable interference screw comprises: screw 1 and the screw cover 2 be sleeved on screw 1, wherein, and the screw cover 2 that screw cover 2 is made for bioabsorbable material.
Concrete, the screw cover 2 that this bioabsorbable material is made is that polyhydroxyalkanoate composite hydroxylapatite is configured to solution, utilizes electrostatic textile technology, under high voltage electric field, is nano level three-dimensional shell-like by material weaving.
Concrete, a series material about polyhydroxyalkanoate, comprise a variety of, polyhydroxyalkanoate (PHA) be a lot of Microbe synthesis a kind of cell in polyester, it is a kind of natural polymeric biomaterial, poly-(3-hydroxybutyrate ester-co-4-butyric ester) (P3HB4HB), poly-(3-hydroxybutyrate ester-co-3-hydroxycaproic ester) (PHBHHx) because of its outstanding mechanical property, good biocompatibility and can degradable property, and organizational project and field of medical materials concerned.
Solution is for gathering (3-hydroxybutyrate ester-co-4-butyric ester) (P3HB4HB) or poly-(3-hydroxybutyrate ester-co-3-hydroxycaproic ester) (PHBHHx) by solute, solvent is dichloromethane, be mixed with the solution that concentration is 4%, again hydroxyapatite powder is added in solution, and ultrasonic wave concussion, be dissolved in the middle of solution, the concentration of hydroxyapatite is 1%.
The cathode voltage of high voltage electric field is 15--20KV, and negative pressure is 2KV.
RhBMP-2 is solvent with acetic acid, is mixed with the solution that concentration is 100ug/ml.
The screw cover 2 that bioabsorbable material is made more specifically is in the solution of polyhydroxyalkanoate composite hydroxylapatite, add a kind of rhBMP-2, utilize electrostatic textile technology, under high voltage electric field, be nano level three-dimensional shell-like by material weaving.
As a kind of preferred embodiment, it is overall that screw cover 2 wraps screw 1.The schematic diagram of the threaded portion of parcel screw 1 has been shown in Fig. 1, and screw cover 2 is when wrapping up screw 1 and being overall, and screw cover 2 extends along the length direction of screw 1, wraps up whole for screw 1.
Conveniently the understanding of the present invention, is described with specific embodiment below.
Embodiment one
Functional type Absorbable rod orthopaedic screw cover 2 of the present invention, the screw cover 2 comprising screw 1 itself and be made up of bioabsorbable material.Described screw overlaps 2 similar condoms and is equally enclosed within screw 1 rivet nut position.Screw cover 2 is that polyhydroxyalkanoate composite hydroxylapatite is configured to solution, utilizes electrostatic textile technology, under high voltage electric field, is nano level three-dimensional shell-like by material weaving.Make screw 1 have better early stage biological stability, prevent postoperative common screw 1 from loosening problem.
Embodiment two
Functional type Absorbable rod orthopaedic screw cover 2 of the present invention, the screw cover 2 comprising screw 1 itself and be made up of bioabsorbable material.Described screw overlaps 2 similar condoms and is equally enclosed within screw 1 rivet nut position.Screw cover 2 is that polyhydroxyalkanoate composite hydroxylapatite is configured to solution, add a kind of rhBMP-2 (rhBMP-2) in solution simultaneously, utilizing electrostatic textile technology, under high voltage electric field, is nano level three-dimensional shell-like by material weaving.In absorbed process, rhBMP-2 has osteogenic induction effect, can induce the generation of area of new bone while increasing biological stability, avoids at present screw 1 clinically to fix insecure, union of fracture delay, the technical problem of malunion or nonunion.
Can be found out by above-mentioned specific embodiment, between the functional type Absorbable rod orthopaedic screw cover 2 that the embodiment of the present invention provides and screw 1 body, there is certain mechanical bonding force, be not easy time fixing to strip off, and after implanting induce newborn osteogenetic while material is spontaneous can be degradable, do not produce acidic metabolite, form bone packing interaction, make screw 1 have better early stage biological stability, prevent postoperative common screw 1 from loosening problem; By Biomechanics test, functional type Absorbable rod orthopaedic screw cover 2 of the present invention has good resisting pull out forces and anti-back-out torsion; Screw of the present invention overlaps 2 applied widely, has good clinical value.
These are only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. a functional anti-loosening orthopaedics bioabsorbable interference screw, is characterized in that, comprising: screw and the screw cover be sleeved on described screw, wherein, and the screw cover that described screw cover is made for bioabsorbable material.
2. functional anti-loosening orthopaedics bioabsorbable interference screw according to claim 1, it is characterized in that, the screw cover that described bioabsorbable material is made is that polyhydroxyalkanoate composite hydroxylapatite is configured to solution, utilize electrostatic textile technology, under the high voltage electric field of 15 to 20KV, be nano level three-dimensional shell-like by material weaving.
3. functional anti-loosening orthopaedics bioabsorbable interference screw according to claim 1, it is characterized in that, the screw cover that described bioabsorbable material is made is in the solution of polyhydroxyalkanoate composite hydroxylapatite, add a kind of rhBMP-2, utilize electrostatic textile technology, under high voltage electric field, be nano level three-dimensional shell-like by material weaving.
4. the functional anti-loosening orthopaedics bioabsorbable interference screw according to any one of claim 1 ~ 3, is characterized in that, it is overall that described screw cover wraps described screw.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410812257.7A CN104434291A (en) | 2014-12-24 | 2014-12-24 | Functional anti-looseness absorbable screw used in orthopaedics department |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410812257.7A CN104434291A (en) | 2014-12-24 | 2014-12-24 | Functional anti-looseness absorbable screw used in orthopaedics department |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104434291A true CN104434291A (en) | 2015-03-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410812257.7A Pending CN104434291A (en) | 2014-12-24 | 2014-12-24 | Functional anti-looseness absorbable screw used in orthopaedics department |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104434291A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104887305A (en) * | 2015-06-29 | 2015-09-09 | 河北瑞诺医疗器械股份有限公司 | Bone screw |
| CN106821483A (en) * | 2015-12-07 | 2017-06-13 | 郑州人造金刚石及制品工程技术研究中心有限公司 | Overlay film type diamond alkene bone nail and preparation method |
| CN110916737A (en) * | 2019-11-26 | 2020-03-27 | 杭州电子科技大学 | Degradable screw and manufacturing method thereof |
| CN113398325A (en) * | 2021-06-11 | 2021-09-17 | 叶川 | Fibrous membrane for enhancing screw stability and inducing bone regeneration and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037426A (en) * | 1988-09-19 | 1991-08-06 | Marlowe Goble E | Procedure for verifying isometric ligament positioning |
| US6162234A (en) * | 1993-03-23 | 2000-12-19 | Freedland; Yosef | Adjustable button cinch anchor orthopedic fastener |
| CN101385872A (en) * | 2008-10-24 | 2009-03-18 | 东华大学 | Method for preparing absorbable biological material artificial blood vessel bracket using electro-spinning |
| CN102036612A (en) * | 2008-03-28 | 2011-04-27 | 骨科技术公司 | Bone anchors for orthopedic applications |
| WO2013146788A1 (en) * | 2012-03-27 | 2013-10-03 | 国立大学法人名古屋大学 | Three-dimensional structure created from material comprising polyhydroxyalkanoate, kit for preparing bone filling material, and intramedullary nail |
| CN103623463A (en) * | 2013-11-15 | 2014-03-12 | 无锡中科光远生物材料有限公司 | Preparation method of electrostatic spinning coating material for accelerating growth of bone tissues |
-
2014
- 2014-12-24 CN CN201410812257.7A patent/CN104434291A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037426A (en) * | 1988-09-19 | 1991-08-06 | Marlowe Goble E | Procedure for verifying isometric ligament positioning |
| US6162234A (en) * | 1993-03-23 | 2000-12-19 | Freedland; Yosef | Adjustable button cinch anchor orthopedic fastener |
| CN102036612A (en) * | 2008-03-28 | 2011-04-27 | 骨科技术公司 | Bone anchors for orthopedic applications |
| CN101385872A (en) * | 2008-10-24 | 2009-03-18 | 东华大学 | Method for preparing absorbable biological material artificial blood vessel bracket using electro-spinning |
| WO2013146788A1 (en) * | 2012-03-27 | 2013-10-03 | 国立大学法人名古屋大学 | Three-dimensional structure created from material comprising polyhydroxyalkanoate, kit for preparing bone filling material, and intramedullary nail |
| CN103623463A (en) * | 2013-11-15 | 2014-03-12 | 无锡中科光远生物材料有限公司 | Preparation method of electrostatic spinning coating material for accelerating growth of bone tissues |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104887305A (en) * | 2015-06-29 | 2015-09-09 | 河北瑞诺医疗器械股份有限公司 | Bone screw |
| CN104887305B (en) * | 2015-06-29 | 2018-03-27 | 河北瑞诺医疗器械股份有限公司 | A kind of bone screw |
| CN106821483A (en) * | 2015-12-07 | 2017-06-13 | 郑州人造金刚石及制品工程技术研究中心有限公司 | Overlay film type diamond alkene bone nail and preparation method |
| CN110916737A (en) * | 2019-11-26 | 2020-03-27 | 杭州电子科技大学 | Degradable screw and manufacturing method thereof |
| CN113398325A (en) * | 2021-06-11 | 2021-09-17 | 叶川 | Fibrous membrane for enhancing screw stability and inducing bone regeneration and preparation method thereof |
| CN113398325B (en) * | 2021-06-11 | 2023-04-21 | 叶川 | Fibrous membrane for enhancing screw stability and inducing bone regeneration and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150325 |