CN104531501A - Pressurizing and draining device applied to DNA synthesizer - Google Patents
Pressurizing and draining device applied to DNA synthesizer Download PDFInfo
- Publication number
- CN104531501A CN104531501A CN201410610767.6A CN201410610767A CN104531501A CN 104531501 A CN104531501 A CN 104531501A CN 201410610767 A CN201410610767 A CN 201410610767A CN 104531501 A CN104531501 A CN 104531501A
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- pressurization
- increased pressure
- synthesis
- pressure board
- electromagnetic drive
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Abstract
The invention relates to a pressurizing and draining device applied to a DNA synthesizer, which comprises a synthesis baseplate, synthesis columns, a pressurizing rubber pad, a pressurizing plate, an external inert gas source and ventilating connectors, wherein the synthesis columns are arranged on the synthesis baseplate; a flange extends upwards out of the periphery of the synthesis baseplate; the flange is parallel to the synthesis columns and is higher than the synthesis columns; the pressurizing rubber pad is arranged on the flange; the pressurizing plate is sealed together with the synthesis baseplate through the pressurizing rubber pad; the ventilating connectors are arranged on the pressurizing plate and used for realizing the communication between an external inert gas source and the upper side of the synthesis columns. The pressurizing and draining device further comprises a pressurizing and draining actuating device which is used for pressurizing the pressurizing plate and the pressurizing rubber pad to seal the pressurizing rubber pad and the synthesis baseplate. Inert gas flows into the space between the upper side of the synthesis columns and the pressurizing plate via the ventilating connectors; and by controlling the pressure of the gas above the synthesis columns, the draining speed of reagents in the synthesis columns can be increased and the reaction speed of the reagents can be controlled.
Description
Technical field
The present invention relates to a kind of pressurization pumping equipment, particularly relate to a kind of pressurization pumping equipment being applied to DNA synthesizer.
Background technology
Artificial-synthetic DNA is the unique channel of directional transformation gene order known at present, is widely used in multiple fields such as protein transformation and life science, as nucleic acid drug, enzyme engineering, gene therapy etc.The step that DNA synthesizer needs deprotection, activation link, block, oxidation etc. different in building-up process, building-up process needs to inject different reagent in synthesis post.
In synthesis post, the speed of response of different reagent is different, and having reacted rear needs, will to synthesize reagent in post emptying.For controlling the speed of response of reagent, realizing the emptying of reagent, needing structure control synthesis post upper gas pressure reasonable in design, also there is no the device of ripe emptying residual agent easily at present.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pressurization pumping equipment being applied to DNA synthesizer, overcomes in prior art still not used for the discharge opeing of DNA synthesizer working process and the defect of cleaning the reliable and stable pumping equipment of link.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of pressurization pumping equipment being applied to DNA synthesizer, comprise synthesis substrate, synthesis post, pressurization rubber cushion, increased pressure board, outside inertia source of the gas and ventilating joint, described synthesis substrate is provided with synthesis post; The periphery of described synthesis substrate extends upward flange, and described flange is parallel with described synthesis post, and higher than synthesizing the height of post; Described flange is provided with described pressurization rubber cushion; Described increased pressure board is by pressurization rubber cushion and described synthesis base plate seals; Described ventilating joint is arranged on described increased pressure board, is communicated with outside inertia source of the gas and synthesizes above post, also comprises for pressurizeing to increased pressure board and pressurization rubber cushion and then make the pressurization discharge opeing drive unit of pressurization rubber cushion and described synthesis base plate seals.The lower end of wherein preferably described ventilating joint can be concordant with the lower surface of described increased pressure board.
The invention has the beneficial effects as follows: pressurization discharge opeing drive unit is installed above increased pressure board and simply can controls this device fast to increased pressure board and the pressurization of pressurization rubber cushion and then make pressurization rubber cushion and described synthesis base plate seals, by ventilating joint, rare gas element is passed into the space of synthesizing above post and between increased pressure board, by controlling the gaseous tension above synthesis post, the reagent in emptying synthesis post and the speed of response controlling reagent can be accelerated.
On the basis of technique scheme, the present invention can also do following improvement.
Further, described pressurization discharge opeing drive unit comprises electromagnetic drive mechanism, electromagnetic drive mechanism permanent seat, and described electromagnetic drive mechanism is fixed on described electromagnetic drive mechanism permanent seat; Described electromagnetic drive mechanism permanent seat is arranged on the periphery of described increased pressure board; Described electromagnetic drive mechanism lower end connects electromagnetic drive axle; Described electromagnetic drive axle is connected with described increased pressure board by web member.
The beneficial effect of above-mentioned further scheme is adopted to be: to be connected with increased pressure board by electromagnetic drive mechanism and increased pressure board can be driven to move up and down, increased pressure board moves downward press seal plate and seal gasket, again by the top of ventilating joint to synthesis post, namely pass into rare gas element in the space between increased pressure board and described synthesis substrate, the residual liquid in synthesis post is discharged or is synthesized the reaction process of reagent in post by the pressure-controlling passing into gas.
Further, described electromagnetic drive mechanism permanent seat comprises pressurization retaining plate, groove and salient, and described groove is arranged on the lower surface of described pressurization retaining plate, and described salient arranges on the upper surface of the pressurization retaining plate corresponding with described groove; Described electromagnetic drive axle enters in groove through described salient; Described electromagnetic drive axle is connected with described increased pressure board by web member.Described electromagnetic drive mechanism permanent seat can be formed in one or split, also can be other all suitable fixing structures.
Further, the shape of described web member and the shape approximation of described electromagnetic drive mechanism permanent seat.
Further, described pressurization discharge opeing drive unit comprises cylinder, cylinder permanent seat, and described cylinder is fixed on described cylinder permanent seat; Described cylinder permanent seat is arranged on the periphery of described increased pressure board; Described cylinder lower end connects cylinder union lever; Described cylinder union lever is connected with described increased pressure board by web member.
The beneficial effect of above-mentioned further scheme is adopted to be: to be connected with increased pressure board by cylinder union lever and increased pressure board can be driven to move up and down, increased pressure board moves downward press seal plate and seal gasket, again by the top of ventilating joint to synthesis post, namely pass into rare gas element in the space between increased pressure board and described synthesis substrate, the residual liquid in synthesis post is discharged or is synthesized the reaction process of reagent in post by the pressure-controlling passing into gas.
Further, described pressurization discharge opeing drive unit comprises pressurization retaining plate, pressurization upper cover, vertical web plate, air bag, air bag ventilating pit, and described pressurization retaining plate is arranged on the periphery of described increased pressure board; Described vertical web plate is fixed on the inside edge of described pressurization retaining plate; Described pressurization upper cover is fixed on the upper end of described vertical web plate; Described air bag is arranged between described pressurization upper cover and described increased pressure board; Described pressurization covers and is provided with air bag ventilating pit, described air bag ventilating pit is communicated with described outside inertia source of the gas and described air bag.
Adopt the beneficial effect of above-mentioned further scheme to be: the sealing, the folding that are realized increased pressure board and described synthesis substrate by the inflation/deflation of air bag, and then control the pressure above synthesis post, accelerate residual liquid and discharge or control reaction process.
Further, also comprise Porous Base, described Porous Base is arranged between described increased pressure board and described pressurization rubber cushion, and the ventilating joint lower end ventage on described increased pressure board is positioned at above described Porous Base, and described ventilating joint is communicated with above outside inertia source of the gas and Porous Base and synthesizes above post.
The beneficial effect of above-mentioned further scheme is adopted to be: owing to being provided with Porous Base between increased pressure board and described extruding rubber cushion, this structure can disperse point flow path direction of ventilating joint gas on increased pressure board, the rare gas element making to enter in each synthesis post is relatively more even, is conducive to the reagent controlling speed of response and get rid of in synthesis post.
Further, the hole on described Porous Base is corresponding with the position of described synthesis post.
The beneficial effect of above-mentioned further scheme is adopted to be: on described Porous Base, the position in hole is corresponding with the position of described synthesis post, the rare gas element passed into from described ventilating joint will evenly spread in each synthesis post, control reaction in synthesis post consistent, cleaning thoroughly.
Accompanying drawing explanation
Fig. 1 is a kind of structural representation being applied to the first embodiment of pressurization pumping equipment of DNA synthesizer of the present invention;
Fig. 2 is of the present invention a kind of structural representation being applied to pressurization pumping equipment the second embodiment of DNA synthesizer;
Fig. 3 is of the present invention a kind of structural representation being applied to the third embodiment of pressurization pumping equipment of DNA synthesizer;
Fig. 4 is of the present invention a kind of pressurization pumping equipment Porous Base syndeton schematic diagram being applied to DNA synthesizer;
Fig. 5 is of the present invention a kind of pressurization pumping equipment increased pressure board structural representation being applied to DNA synthesizer.
In accompanying drawing, the list of parts representated by each label is as follows:
1, substrate is synthesized, 2, increased pressure board, 3, pressurization rubber cushion, 4, synthesis post, 5, ventilating joint, 6, electromagnetic drive mechanism, 7, web member, 8, pressurization retaining plate, 9, cylinder, 10, air bag, 11, air bag ventilating pit, 12, pressurization upper cover, 13, Porous Base, 14, vertical web plate.
Embodiment
Be described principle of the present invention and feature below in conjunction with accompanying drawing, example, only for explaining the present invention, is not intended to limit scope of the present invention.
As shown in Figure 1, Figure 2, shown in Fig. 3 and Fig. 5, a kind of pressurization pumping equipment being applied to DNA synthesizer of the present invention, comprise synthesis substrate 1, synthesis post 4, pressurization rubber cushion 3, increased pressure board 2, outside inertia source of the gas and ventilating joint 5, described synthesis substrate 1 is provided with synthesis post 4; The periphery of described synthesis substrate 1 extends upward flange 1a, and described flange 1a is parallel with described synthesis post 4, and the height of highly a little higher than synthesis post 4; Described flange 1a is provided with described pressurization rubber cushion 3; Described pressurization rubber cushion 3 is arranged on described flange 1a, and described increased pressure board 2 is sealed by pressurization rubber cushion 1a and described synthesis substrate 1; Described ventilating joint 5 is arranged on described increased pressure board 2, is communicated with outside inertia source of the gas and synthesizes above post 4, also comprises the pressurization discharge opeing drive unit for pressurizeing to increased pressure board 2 and pressurization rubber cushion 3 and then make pressurization rubber cushion 3 and described synthesis substrate 1 seal.Described pressurization discharge opeing drive unit main purpose be for increased pressure board apply pressure by increased pressure board by described pressurization rubber cushion close and described synthesis base plate seals, above synthesis post, pass into rare gas element by ventilating joint again, above synthesis post, form the speed of response etc. that the residual liquid in synthesis post is discharged or control reagent in synthesis post by air pressure.
Fig. 1 is the first embodiment of the present invention, and the pressurization discharge opeing drive unit of employing of the present invention comprises electromagnetic drive mechanism 6, electromagnetic drive mechanism permanent seat, and described electromagnetic drive mechanism 6 is fixed on described electromagnetic drive mechanism permanent seat; Described electromagnetic drive mechanism 6 permanent seat is arranged on the periphery of described increased pressure board 2; Described electromagnetic drive mechanism 6 lower end connects electromagnetic drive axle 6a; Described electromagnetic drive axle 6a is connected with described increased pressure board 2 by web member 7.
Described electromagnetic drive mechanism permanent seat comprises pressurization retaining plate 8, groove 8a and salient 8b, and described groove 8a is arranged on the lower surface of described pressurization retaining plate 8, and described salient 8b arranges on the upper surface of the pressurization retaining plate 8 corresponding with described groove 8a; Described electromagnetic drive axle 6a enters in groove 8a through described salient 8b; Described electromagnetic drive axle 6a is connected with described increased pressure board 2 by web member 7.The shape of web member 7 adopted in this embodiment and the shape approximation of described electromagnetic drive mechanism permanent seat.
Fig. 2 is the second embodiment of the present invention, and the pressurization discharge opeing drive unit of employing of the present invention comprises cylinder 9, cylinder permanent seat, and described cylinder 9 is fixed on described cylinder permanent seat; Described cylinder permanent seat is arranged on the periphery of described increased pressure board 2; Described cylinder 9 lower end connects cylinder union lever 9a; Described cylinder union lever 9a is connected with described increased pressure board 2 by web member 7.
Fig. 3 is the third embodiment of the present invention, the pressurization discharge opeing drive unit of employing of the present invention comprises pressurization retaining plate 8, pressurization upper cover 12, vertical web plate 14, air bag 10, air bag ventilating pit 11, and described pressurization retaining plate 8 is arranged on the periphery of described increased pressure board 2; Described vertical web plate 14 is fixed on the inside edge of described pressurization retaining plate 8; Described pressurization upper cover 12 is fixed on the upper end of described vertical web plate 14; Described air bag 10 is arranged between described pressurization upper cover 12 and described increased pressure board 2; Described pressurization upper cover 12 is provided with air bag ventilating pit 11, and described air bag ventilating pit 11 is communicated with described outside inertia source of the gas and described air bag 10.
Fig. 4 is the present invention's the 4th kind of embodiment, and basic structure can make the first embodiment or the second embodiment or the third embodiment, mainly by being provided with Porous Base 13 between described increased pressure board 2 and described pressurization rubber cushion 3.Described Porous Base 13 is arranged between described increased pressure board 2 and described pressurization rubber cushion 3, ventilating joint 5 lower end ventage on described increased pressure board 2 is positioned at above described Porous Base 13, and described ventilating joint 5 is communicated with above outside inertia source of the gas and Porous Base 13 and synthesizes above post 4.Hole on described Porous Base 13 is corresponding with the position of described synthesis post 4.The rare gas element passed into from described ventilating joint 5 will evenly spread in each synthesis post, controls the consistent or thorough erase residual reagent of reaction in synthesis post 4.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. be applied to a pressurization pumping equipment for DNA synthesizer, comprise synthesis substrate, synthesis post, pressurization rubber cushion, increased pressure board, outside inertia source of the gas and ventilating joint, described synthesis substrate is provided with synthesis post; The periphery of described synthesis substrate extends upward flange, and described flange is parallel with described synthesis post, and higher than synthesizing the height of post; Described flange is provided with described pressurization rubber cushion; Described increased pressure board is by pressurization rubber cushion and described synthesis base plate seals; Described ventilating joint is arranged on described increased pressure board, is communicated with outside inertia source of the gas and synthesizes above post, it is characterized in that, also comprises for pressurizeing to increased pressure board and pressurization rubber cushion and then make the pressurization discharge opeing drive unit of pressurization rubber cushion and described synthesis base plate seals.
2. a kind of pressurization pumping equipment being applied to DNA synthesizer according to claim 1, it is characterized in that, described pressurization discharge opeing drive unit comprises electromagnetic drive mechanism, electromagnetic drive mechanism permanent seat, and described electromagnetic drive mechanism is fixed on described electromagnetic drive mechanism permanent seat; Described electromagnetic drive mechanism permanent seat is arranged on the periphery of described increased pressure board; Described electromagnetic drive mechanism lower end connects electromagnetic drive axle; Described electromagnetic drive axle is connected with described increased pressure board by web member.
3. a kind of pressurization pumping equipment being applied to DNA synthesizer according to claim 2, it is characterized in that, described electromagnetic drive mechanism permanent seat comprises pressurization retaining plate, groove and salient, described groove is arranged on the lower surface of described pressurization retaining plate, and described salient arranges on the upper surface of the pressurization retaining plate corresponding with described groove; Described electromagnetic drive axle enters in groove through described salient; Described electromagnetic drive axle is connected with described increased pressure board by web member.
4. a kind of pressurization pumping equipment being applied to DNA synthesizer according to claim 3, is characterized in that, the shape of described web member and the shape approximation of described electromagnetic drive mechanism permanent seat.
5. a kind of pressurization pumping equipment being applied to DNA synthesizer according to claim 1, it is characterized in that, described pressurization discharge opeing drive unit comprises cylinder, cylinder permanent seat, and described cylinder is fixed on described cylinder permanent seat; Described cylinder permanent seat is arranged on the periphery of described increased pressure board; Described cylinder lower end connects cylinder union lever; Described cylinder union lever is connected with described increased pressure board by web member.
6. a kind of pressurization pumping equipment being applied to DNA synthesizer according to claim 1, it is characterized in that, described pressurization discharge opeing drive unit comprises pressurization retaining plate, pressurization upper cover, vertical web plate, air bag, air bag ventilating pit, and described pressurization retaining plate is arranged on the periphery of described increased pressure board; Described vertical web plate is fixed on the inside edge of described pressurization retaining plate; Described pressurization upper cover is fixed on the upper end of described vertical web plate; Described air bag is arranged between described pressurization upper cover and described increased pressure board; Described pressurization covers and is provided with air bag ventilating pit, described air bag ventilating pit is communicated with described outside inertia source of the gas and described air bag.
7. a kind of pressurization pumping equipment being applied to DNA synthesizer according to any one of claim 1 to 6, it is characterized in that, also comprise Porous Base, described Porous Base is arranged between described increased pressure board and described pressurization rubber cushion, ventilating joint lower end ventage on described increased pressure board is positioned at above described Porous Base, and described ventilating joint is communicated with above outside inertia source of the gas and Porous Base and synthesizes above post.
8. a kind of pressurization pumping equipment being applied to DNA synthesizer according to claim 7, it is characterized in that, the hole on described Porous Base is corresponding with the position of described synthesis post.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410610767.6A CN104531501B (en) | 2014-11-03 | Be applied to pressurization drain of DNA synthesizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410610767.6A CN104531501B (en) | 2014-11-03 | Be applied to pressurization drain of DNA synthesizer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104531501A true CN104531501A (en) | 2015-04-22 |
| CN104531501B CN104531501B (en) | 2017-01-04 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106167759A (en) * | 2016-08-26 | 2016-11-30 | 江苏领坤生物科技有限公司 | A kind of gas liquid-way system for DNA synthesizer |
| CN106220700A (en) * | 2016-08-26 | 2016-12-14 | 江苏领坤生物科技有限公司 | A kind of high flux DNA synthesizer |
| CN107858285A (en) * | 2017-12-13 | 2018-03-30 | 刘延群 | Split type bioreactor |
| CN109021050A (en) * | 2018-08-24 | 2018-12-18 | 江苏领坤生物科技有限公司 | A kind of biosynthesis instrument |
| CN114410456A (en) * | 2021-12-30 | 2022-04-29 | 江苏领坤生物科技有限公司 | Pressure liquid draining device for DNA synthesizer |
| CN115155504A (en) * | 2022-06-15 | 2022-10-11 | 北京擎科生物科技有限公司 | Piston type solid-phase synthesis system and synthesis method |
| CN116218638A (en) * | 2023-05-08 | 2023-06-06 | 江苏东玄基因科技有限公司 | Primer synthesis quick locking device |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106167759A (en) * | 2016-08-26 | 2016-11-30 | 江苏领坤生物科技有限公司 | A kind of gas liquid-way system for DNA synthesizer |
| CN106220700A (en) * | 2016-08-26 | 2016-12-14 | 江苏领坤生物科技有限公司 | A kind of high flux DNA synthesizer |
| CN106220700B (en) * | 2016-08-26 | 2019-05-14 | 江苏领坤生物科技有限公司 | A kind of high throughput DNA synthesizer |
| CN107858285A (en) * | 2017-12-13 | 2018-03-30 | 刘延群 | Split type bioreactor |
| CN109021050A (en) * | 2018-08-24 | 2018-12-18 | 江苏领坤生物科技有限公司 | A kind of biosynthesis instrument |
| CN114410456A (en) * | 2021-12-30 | 2022-04-29 | 江苏领坤生物科技有限公司 | Pressure liquid draining device for DNA synthesizer |
| CN114410456B (en) * | 2021-12-30 | 2024-03-22 | 江苏领坤生物科技有限公司 | Pressurized liquid discharge device for DNA synthesizer |
| CN115155504A (en) * | 2022-06-15 | 2022-10-11 | 北京擎科生物科技有限公司 | Piston type solid-phase synthesis system and synthesis method |
| CN115155504B (en) * | 2022-06-15 | 2024-03-29 | 北京擎科生物科技股份有限公司 | Piston type solid phase synthesis system and synthesis method |
| CN116218638A (en) * | 2023-05-08 | 2023-06-06 | 江苏东玄基因科技有限公司 | Primer synthesis quick locking device |
| CN116218638B (en) * | 2023-05-08 | 2023-08-22 | 江苏东玄基因科技有限公司 | Primer synthesis quick locking device |
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Granted publication date: 20170104 Termination date: 20181103 |