CN104688331A - Catheter device used for regulating nerves - Google Patents
Catheter device used for regulating nerves Download PDFInfo
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- CN104688331A CN104688331A CN201310662004.1A CN201310662004A CN104688331A CN 104688331 A CN104688331 A CN 104688331A CN 201310662004 A CN201310662004 A CN 201310662004A CN 104688331 A CN104688331 A CN 104688331A
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Abstract
The invention discloses a catheter device used for regulating nerves. The catheter device comprises a regulation assembly used for regulating the nerves, and further comprises a conveying part used for conveying the regulation assembly to a position close to the nerves and a sheath tube used for sleeving the conveying part, wherein the regulation assembly comprises at least two electrodes used for transmitting regulation energy to the nerves and an electrode bearing part used for bearing the electrodes; the electrodes are connected with lead wires used for conveying the regulation energy; the electrode bearing part comprises an axial filament and an insulating sheath; the axial filament is positioned in a cavity of the insulating sheath; the insulating sheath is sleeved with the electrodes. The electrode bearing part has a first shape and a second shape; when the electrode bearing part is in the first shape, the regulation assembly is suitable for moving in blood vessels; when the electrode bearing part is in the second shape, the electrodes on the electrode bearing part is in a position suitable for transmitting the regulation energy to the nerves.
Description
Technical field
The present invention relates to electrosurgery, particularly relating to a kind of for regulating neural pipe guide.
Background technology
Intractable hypertension, i.e. use 3 kinds or more medicine (all having used a diuretic) still unmanageable hypertension (sBP >=160mmHg), more common clinically, its paathogenic factor is numerous, pathogenesis is indefinite, medication effect is very poor, and Diagnosis and Treat technology is still not mature enough, one of great difficult problem becoming hypertension therapeutic.
Up-to-date animal and clinical laboratory data prove to lower intractable hypertension significantly enduringly to the adjustment (such as removing sympathetic nerve) of kidney nerve, the renal artery radiofrequency ablation art that such as latest developments go out.Renal artery radiofrequency ablation art is a kind of by electrode catheter intravascular is sent into specific part in renal artery, and release radio-frequency current causes renal artery sympathetic nerve local solidification downright bad, reaches denervated interventional techniques.Radio-frequency current damage range is little, and body can not be caused to endanger, and therefore renal artery radiofrequency ablation art has become a kind of orthosympathetic method of effective removal renal artery.
In addition, the adjustment of kidney nerve is proved to be and has certain effect to the multiple disease relevant to kidney, particularly the relevant disease that causes of renal sympathetic nerve overactivity.Such as, congestive heart failure (CHF) can cause abnormal high renal sympathetic nerve activation, thus causes the minimizing of water and the sodium removed from health, and increases the secretion of feritin.The renin secretion increased causes Renal vascular to shrink, and causes the reduction of renal blood flow.Thus kidney can make the spiral decline of heart failure condition extend for the reaction of heart failure.
Although have report in pertinent literature or patent for regulating the orthosympathetic related equipment of renal artery, current existing apparatus has the defects such as the high or inefficiency of operation inconvenience, cost of manufacture.
Given this, the invention provides a kind of device for regulating nerve newly.
Summary of the invention
Because the above-mentioned defect of prior art, the object of this invention is to provide relevant disease is treated in a kind of operation easily pipe guide for regulating nerve.
Provided by the present invention for regulating neural device, comprise the adjusting part for regulating described nerve, described adjusting part comprises at least two electrodes for adjusting energy being delivered to described nerve and is used for carrying the electrode load bearing component of described electrode, and described pipe guide also comprises the transfer unit for being transported to by described adjusting part near the position of described nerve and is coated at the sheath pipe of described transfer unit; Described electrode is connected with the wire of the described adjusting energy of conveying;
It is characterized in that, described electrode load bearing component comprises axial filament and insulating coating, and described axial filament is positioned at the cavity of described insulating coating, and described electrode sleeve is connected to the outside of described insulating coating;
Described electrode load bearing component has the first shape and the second shape, described pipe guide is configured: when described sheath pipe slides along described transfer unit and is coated at described adjusting part, described electrode load bearing component is in the first shape, when described sheath pipe departs from described adjusting part, described electrode load bearing component is in the second shape;
Wherein, under described first shape, described adjusting part is applicable to moving in the blood vessel, and the electrode under described second shape on described electrode load bearing component is in the position being applicable to described adjusting energy being delivered to described nerve.
Preferably, the diameter of described axial filament is 0.10-0.25mm.
Preferably, the material of described axial filament is Ni-Ti alloy.
Preferably, described axial filament surface thermoplastic one deck insulating polymer material.More preferably, described macromolecular material is PTFE, FEP or PET.
Preferably, the internal diameter of described sheath pipe is 1.0-1.25mm, and external diameter is for being less than 1.30-1.45mm.
Preferably, the material of described insulating coating is Pebax or TPU.Preferably, the hardness range of described insulating coating is 50A-90A or 30D-60D.
Preferably, the external diametrical extent of described insulating coating is 0.8-1.1mm, and wall thickness is 0.05-0.15mm.
Preferably, the first shape of described electrode load bearing component is straight or approximate straight elongate, bar shaped, thread or fibrous.
Preferably, the second shape of described electrode load bearing component is spiral type or is approximately spiral type.More preferably, described spiral diameter is 4-12mm.
Preferably, described electrode adhesion, in described insulating coating, uses glue to form seamlessly transitting between described electrode and described insulating coating.More preferably, described glue is that UV solidifies glue, epoxide-resin glue or its mixture.
Preferably, described wire bonds is in the inner surface of described electrode.
Preferably, described wire enters the cavity of described insulating coating by the opening on described insulating coating.
Preferably, the number of described electrode is 2-6, and when described electrode load bearing component is in the second shape, adjacent electrode is 4-15mm in the distance axially of described blood vessel.More preferably, the number of described electrode is 4.
Preferably, described nerve is for being positioned at the renal sympathetic nerve on people's renal artery, and described " position near described nerve " refers to and be positioned at described renal artery.
Preferably, described adjustment refer to by damage or non-invasive mode remove or reduce the activation of described nerve.
Preferably, described energy is one or more in radio frequency, heat, cooling, electromagnetic energy, ultrasound wave, microwave or luminous energy.
Preferably, described blood vessel behaviour renal artery.
Preferably, described " being applicable to moving in the blood vessel " refers to when described adjusting part moves in the blood vessel, and described adjusting part is injured blood vessel wall not.
Preferably, described " being applicable to moving in the blood vessel " refers to the internal diameter that the full-size of described adjusting part in the radial direction of described blood vessel is not more than described blood vessel.
Preferably, described " being applicable to moving in the blood vessel " refers to the full-size of described adjusting part in the radial direction of described blood vessel and is not more than 3mm.
Preferably, described " being applicable to moving in the blood vessel " refers to easily through vascular bending section.
Preferably, described " being applicable to the position described adjusting energy being delivered to described kidney nerve " refer to when described adjustment member in the blood vessel time, at least one electrode is in the position of contact blood vessel wall.
Preferably, described " being applicable to the position described adjusting energy being delivered to described kidney nerve " refers to the full-size of described adjusting part in the radial direction of described blood vessel is 4-12mm, and at least one electrode is in full-size place.
Preferably, the far-end of described electrode load bearing component is provided with the guard block for reducing or avoid vascular damaged.More preferably, described guard block is spring or elastic polymer material.More preferably, the material of described spring is Ni-Ti or stainless steel alloy.Further preferably, the length of described spring is 15-50mm.
More preferably, the spiral external diameter 0.25-0.6mm of described spring, the diameter of spring wire is 0.045-0.12mm.
Preferably, the far-end of described insulating coating is coated at the near-end of described guard block.
Preferably, the shape of described transfer unit is elongate, bar shaped, thread or fibrous one, and the far-end of described transfer unit is connected with the near-end of described electrode load bearing component.More preferably, the material of described transfer unit is Ni-Ti compo pipe.
More preferably, outer surface pyrocondensation one deck macromolecular material of described transfer unit.Further preferably, described macromolecular material is PET/FEP/PTFE.
More preferably, described transfer unit is hollow tubular, and its external diameter is 0.8-1.0mm, and wall thickness is 0.05-0.15mm.
More preferably, described transfer unit comprises cut length and hard pipeline section.
Preferably, described Control Component comprises the handle gripped for user, and described transfer unit, axial filament, sheath pipe and wire are installed on described handle.
More preferably, described handle and the connection cord of external energy generator are set to integrally or the independently two parts be connected by conversion port.
Preferably, described sheath pipe comprises internal layer and skin.More preferably, the material of described internal layer is PTFE, and wall thickness is 0.015-0.5mm.
More preferably, described outer field macromolecular material is for containing 20-40wt%BaSO
4pebax or TPU.
Preferably, described sheath pipe comprises braiding webmaster.
More preferably, described braiding webmaster comprises the first braided wires section, the second braided wires section and the 3rd braided wires section.
More preferably, the braided wires of described first braided wires section, the second braided wires section and the 3rd braided wires section is stainless steel silk or Ni-Ti silk.
More preferably, the hardness of described first braided wires section is 25 ± 15D or 50A-90A.
More preferably, the hardness of described second braided wires section is 40 ± 15D.
More preferably, the hardness of described 3rd braided wires section is 72 ± 15D.
More preferably, described first braided wires section, the second braided wires section are identical with the weaving manner of the braided wires of the 3rd braided wires section, and outer field Pebax hardness is different.
More preferably, described first braided wires section, the second braided wires section are different with the weaving manner of the braided wires of the 3rd braided wires section, and outer field Pebax hardness is identical or different.
Provided by the present invention for regulating neural device operation convenient, and can regulate multiple neural site simultaneously or selective control be carried out to some neural site, thus increase work efficiency, and improve the accuracy for the treatment of further.
Be described further below with reference to the technique effect of accompanying drawing to design of the present invention, concrete structure and generation, to understand object of the present invention, characteristic sum effect fully.
Accompanying drawing explanation
Fig. 1 is the structural representation of people's kidney and linked groups;
Fig. 2 is the arteriorenal structural representation of people;
Fig. 3 is provided by the invention for regulating the ingredient schematic diagram of a kind of detailed description of the invention of neural device, the figure shows the second shape of electrode load bearing component;
Fig. 4 is the schematic diagram of the another kind of state for regulating neural device shown in Fig. 3, the figure shows the first shape of electrode load bearing component;
Fig. 5 is the sectional view of the first shape of the electrode load bearing component for regulating neural device shown in Fig. 4;
Fig. 6 is of the present invention for regulating the part sectioned view of the sheath pipe of a kind of detailed description of the invention of neural device;
Fig. 7 is of the present invention for regulating the part sectioned view of the sheath pipe sheath pipe of the another kind of detailed description of the invention of neural device;
Fig. 8 is of the present invention for regulating the part sectioned view of the transfer unit of a kind of detailed description of the invention of neural device;
In the present invention, the abbreviation of using:
PTFE refers to politef, i.e. Polytetrafluoroethene
FEP refers to fluorinated ethylene propylene copolymer, i.e. Fluorinated ethylene propylene
PET refers to polyethylene terephthalate, i.e. Polyethylene terephthalate
The polyether block phthalein amine elastomer of the performance that Atochem (FR) Cedex 22, 94091 Paris La Defense, France of Pebax fingering state (ATO Chimie) develops between synthetic rubber and thermoplastic polyurethane, its trade mark is called Pebax.
TPU refers to Polyurethane Thermoplastic Elastomer rubber, i.e. Thermoplastic polyurethanes.
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, the present invention will be further described.For convenience of explanation, by the close user (or handle) of device or parts or away from needing the one end in the neural site regulated to be called " near-end " in the present invention, by device or parts away from user (or handle) or near needing the one end in the neural site regulated to be called " far-end ".
In the present invention adjustment nerve refer to by damage or non-invasive mode remove or reduce the activation of described nerve.Fig. 1-Fig. 4 shows provided by the present invention for regulating neural device and the preferred detailed description of the invention of one of using method thereof.This detailed description of the invention is example for the device of mediator's kidney nerve.
Fig. 1-Fig. 2 shows linked groups and the structure of people's kidney.As shown in Figure 1, Ren Shen linked groups comprises kidney K anatomically, and kidney K is supplied to oxygen containing blood by renal artery RA.Renal artery RA is connected to heart via the aortic artery AA of abdominal part.The blood of deoxidation flows to heart via renal veins RV and postcava IVC from kidney.Fig. 2 is the anatomical part of diagram kidney in more detail.More specifically, kidney anatomy also comprises the neural RN of kidney along the axial L longitudinal extension of renal artery RA.The neural RN of kidney is generally in the adventitia of described tremulous pulse.In this specific embodiment, the device provided is positioned at the neural RN of kidney on renal artery RA for regulating, and described adjustment refers to the activation being removed or reduce the neural RN of kidney by damage or non-invasive mode.As the change of this detailed description of the invention, if need to regulate the nerve at other position (such as, heart related neural), or need other regulative mode (such as, need further to improve neural activation), those skilled in the art can according to the present invention make can rational expectation, the adjustment that do not need to be put to creative work.
Fig. 3 and Fig. 4 shows the ingredient for regulating neural device in this detailed description of the invention.As shown in Figure 3 and Figure 4, first this device comprises adjusting part 100; Adjusting part 100 comprises electrode 101 and electrode load bearing component 102.When electrode is in time needing the neural site regulated, electrode discharges certain energy and acts on this neural site, thus plays the effect regulating this neural site (such as, reduce or eliminate orthosympathetic activation).
Electrode can realize this object by heat being delivered to this neural site.Such as, heat transfer heating mechanism for neuroregulation can comprise heating ablation and the non-thermal change that melts or damage, such as, the temperature of target nerve fiber can be increased to over required threshold value to realize the non-thermal change melted, or exceed higher temperature to realize the thermal change melted.Such as, target temperature can about 37 DEG C-45 DEG C (the thermal change temperature for non-thermal ablation), or described target temperature can at about 45 DEG C or higher, for the thermal change melted.
Electrode also can realize this object by cooling being delivered to this neural site.Such as, the temperature of target nerve fiber is reduced to less than about 20 DEG C to realize the thermal change of non-frozen, or the temperature of target nerve fiber is reduced to less than about 0 DEG C to realize freezing thermal change.
Electrode also can by being applied to target nerve fiber to realize by energy field.This energy field can comprise: electromagnetic energy, radio frequency, ultrasound wave (comprising high-intensity focusing ultrasonic wave), microwave, luminous energy (comprising laser, infrared ray and near infrared ray) etc.Such as, thermoinducible neuroregulation can by by pulse or continuous print heat energy field be delivered to target nerve fiber and realize.Wherein, a kind of ratio more preferably energy mode be the pulse heat energy of pulse radiation frequency electric field or other type.The pulse heat energy of pulse radiation frequency electric field or other type can facilitate larger heat level, longer total duration and/or better controlled intravascular renal neuroregulation to treat.
No matter by which kind of energy mode realize regulating neural object, when user uses device provided by the present invention to carry out work, electrode needs to be electrically connected with this energy of generation (such as radiofrequency generator) or the equipment that makes electrode itself produce this energy.The prior art (such as, arranging the interface for connecting these equipment, can realize plug and play during use in apparatus of the present invention) that the connection of these equipment and electrode and these equipment is well known to those skilled in the art, no longer describes in detail here.
In this embodiment, electrode 101 near the mode in the neural site of the kidney needing to regulate is: enter human body via blood vessel, by renal artery inwall near neural site.Therefore, when the device using this detailed description of the invention to provide carries out work, technical issues that need to address are: should realize electrode and can be close to blood vessel thus the nerve of effect relevant position, need again electrode can move easily in the blood vessel, and not injured blood vessel wall.This detailed description of the invention adopts following technical scheme to solve this technical problem: electrode load bearing component 102 comprises axial filament 103 and insulating coating 104, and axial filament 103 is positioned at the cavity of insulating coating 104, and electrode 101 is socketed on the outside of insulating coating 104; Electrode load bearing component 102 has the first shape (as shown in Figure 4) and the second shape (as shown in Figure 3).As shown in Figure 4, the first shape is straight or close to straight bar shaped (or elongate is fibrous or thread), the cross section of this bar shaped is preferably circular or sub-circular, and the widest part of cross section is less than the interior diameter of blood vessel.Like this, under the first shape, when adjusting part 100 moves in the blood vessel, adjusting part 100 can not injured blood vessel wall.When needing to regulate the nerve on renal artery, because the arteriorenal interior diameter of people is generally 4-7mm, therefore, the full-size of adjusting part 100 in arteriorenal radial direction is not more than 4mm, preferably be set to 1-2mm, both can meet at Ink vessel transfusing convenient mobile, and there is again enough rigidity and be convenient to make, and the size of the wound of patient can be reduced.As the change of this detailed description of the invention, the first shape also can allow certain bending or corrugated bending, and its cross section also can be other shape, as long as its smooth surface, can move and not injured blood vessel wall at Ink vessel transfusing easily.
Under the second shape of electrode load bearing component 102, the electrode 101 of adjusting part 100 is in the position being applicable to adjusting energy being delivered to kidney nerve.As shown in Figure 3, in this specific embodiment, the second shape entirety of electrode load bearing component 102 is spiral type.When electrode load bearing component 102 entirety is spiral type, in the radial direction of blood vessel (axis perpendicular to blood vessel), the widest part of adjusting part 100 is larger than the first shape, and the electrode that so just can make it to carry comes close to or in contact with blood vessel wall, thus neural near kidney.Through groping, consider that blood vessel has certain elasticity, it is more suitable that the diameter of spiral is set to 4-8mm.Such as, for the individuality (such as internal diameter is about 4mm) that renal artery internal diameter is less, the diameter of spiral can be set to about 5mm; For the individuality (such as internal diameter is about 7mm) that renal artery internal diameter is larger, the diameter of spiral can be set to about 8mm.As the change of this detailed description of the invention, the second shape also can be other shape, such as, has round and smooth bending irregular shape, as long as when described electrode load bearing component in the blood vessel time, electrode is in the position contacting blood vessel wall.
In this specific embodiment, electrode 101 is ring-type, and is socketed in the outer surface of insulating coating 104.Like this, when electrode load bearing component 102 is spiral type (in renal artery), the electrode 101 on electrode load bearing component 102 is in the position (neural near kidney) of contact renal artery inwall, so just can carry out adjustment work.In order to make electrode 101 firmly be arranged on insulating coating 104, and reducing the damage to blood vessel wall as far as possible, glue can be used to be bonded on insulating coating 104 by electrode 101, and formed and seamlessly transit 106 between electrode 101 and insulating coating 104.This kind of glue can select UV to solidify glue, epoxide-resin glue or its mixture, has both had the biocompatibility that can reach medical application, and has had certain cohesive force again to metal alloy and macromolecular material.In addition, insulating coating 104 has opening (not shown) in the position of electrodes, the wire 501 being connected to energy generation apparatus (such as radiofrequency generator) is welded on the inner surface of electrode 101, and wire 501 enters the cavity of insulating coating 104 by the opening on insulating coating 104.Such set-up mode can make wire 501 be connected to energy generation apparatus by the internal cavities of pipe guide, avoid the outer surface that must be arranged on transfer unit in order to insulate and cause the rough technology drawback of the outer surface of transfer unit, thus avoiding because the uneven problems caused of outer surface of transfer unit.When having multiple electrode, need to arrange many respectively by the wire 501 of multiple Electrode connection to energy generation apparatus.Electrode load bearing component 102 can also be arranged the element (such as, thermocouple) for measuring tempeature and corresponding wire 501, the routine being arranged as this area of wire and thermocouple is arranged, and no longer describes in detail here.
In this specific embodiment, the number of electrode 101 is four.When electrode load bearing component 102 is in the second shape (helical form), adjacent electrode is that 4-15mm is more suitable at the distance D axially of blood vessel.In general, when carrying out the operation of kidney nerve ablation, 3-8 site of kidney nerve is melted.Therefore, when utilizing the device in this detailed description of the invention to carry out work, the location (making electrode contact blood vessel) of Primary regulation assembly can complete melting of four sites, and completes whole ablative surgery and only need the positioning instant carrying out twice adjusting part can.As the change of this detailed description of the invention, the number of electrode also can be set to 2-6, if but number is more, the cost of manufacture of whole device can be increased; If number is less, the work efficiency of ablative surgery can be reduced.The metal or metal alloy that the material of electrode can adopt biocompatibility better or more stable, such as platinum group metal (as platinumiridio).
In this specific embodiment, axial filament 103 is preset as spiral type, and material is Ni-Ti alloy, and diameter is 0.10-0.25mm; Axial filament 103 surperficial thermoplastic one deck insulating polymer material, this floor height molecular material is PTFE, FEP or PET.Insulating coating 104 is the relatively soft high molecule plastic of material, and as Pebax or TPU, the hardness range of insulating coating 104 is 50A-90A or 30D-60D, and external diametrical extent is 0.8-1.1mm, and wall thickness is 0.05-0.15mm.Can add or not add developing materials under X-ray in the material of insulating coating 104, as the BaSO of 20wt%
4.The far-end of insulating coating 104 is also provided with guard block 105.An effect of guard block 105 reduces or avoids vascular damaged, when touching blood vessel wall, because self is enough soft and can resilience rapidly, can not cause damage to blood vessel; Another effect of guard block 105 plays guide effect to whole pipe guide, and when running into the bending place of blood vessel, self can bend according to the bending degree of blood vessel, thus guides whole pipe guide smoothly by the bending place of blood vessel; Guard block 105 can be the relatively soft object of one section of material, and macromolecular material as relatively soft in material or spring, be socketed on the far-end of insulating coating 104, avoids the far-end injured blood vessel of electrode load bearing component 102.The material of this kind of spring is Ni-Ti or stainless steel alloy, and pitch is closing twist, can meet aeroelastic requirements.The length of this kind of spring is 25-50mm.Also spiral external diameter can be selected to be the spring of 0.25-0.6mm.Also the diameter of spring wire can be selected to be 0.045-0.12mm.
Pipe guide in this detailed description of the invention also comprises the transfer unit 201 for being transported to by adjusting part 100 near the position (being namely transported in renal artery) of kidney nerve and is coated at the sheath pipe 301 of transfer unit 201, and sheath pipe 301 makes electrode load bearing component 102 convert (as shown in Figure 3 and Figure 4) between the first shape and the second shape.Shown in Fig. 4, the far-end of transfer unit 201 is connected with the near-end of insulating coating 104.The shape of transfer unit 201 is bar shaped (or elongate is fibrous or thread), and have the rigidity and flexible that are applicable to movement in the blood vessel, its length can be arranged as required.Such as, if user needs by being transported in renal artery through femoral artery place by adjusting part 100, the length that can configure transfer unit 201 is the most suitable about 80cm to 130cm(105cm); If user needs to be transported in renal artery by trans-radial place by adjusting part 100, the length that can configure transfer unit 201 is the most suitable about 130cm to 160cm(155cm).The cross section of transfer unit 201 is preferably circular, hollow tubular, more preferably Ni-Ti pipe, outer surface pyrocondensation one deck macromolecular material of transfer unit 201, such as PET, FEP or PTFE.The external diameter of transfer unit 201 is 0.8-1.0mm, and wall thickness is 0.05-0.15mm.As shown in Figure 8, in another particular embodiment of the invention, transfer unit 201 comprises cut length 202 and hard pipeline section 203, cut length 202 is the transition between the far-end of transfer unit 201 and hard pipeline section 203, easy bending, thus make transfer unit 201 than being easier to and enter into renal artery from aorta, can by the soft durometer regulating cutting mode control cut length.
In this specific embodiment, sheath pipe 301 is coated at the outside of transfer unit 201 and can slides along transfer unit 201.The material of sheath pipe 301 is macromolecular material, and as Pebax or TPU, slightly harder than the material of electrode load bearing component 102, hardness is 50A-50D.The internal diameter of sheath pipe 301 is 1.05-1.2mm, and external diameter is for being less than 1.35mm, and sheath pipe 301 is coated at whole transfer unit 201 and is connected with shape controlling assembly 402.In addition, the second shape of electrode load bearing component 102 is that electrode load bearing component is not by own form during External Force Acting.That is, electrode load bearing component 102 entirety when not being subject to External Force Acting is spiral type.This detailed description of the invention adopts following technical scheme control electrode load bearing component 102 to change between the first shape and the second shape: user handles the operation that shape controlling assembly 402 carries out pushing and retracting, and makes sheath pipe 301 be coated at electrode load bearing component 102 and depart from electrode load bearing component 102; When sheath pipe 301 is coated at electrode load bearing component 102, because the hardness ratio electrode load bearing component 102 of the material of sheath pipe 301 far-end is large, electrode load bearing component 102 can present the first shape (straight or close to straight bar shaped); When sheath pipe 301 departs from electrode load bearing component 102, due to the elastic acting force of electrode load bearing component 102 self, electrode load bearing component 102 returns to the second shape (helical form); Realize electrode load bearing component 102 therefrom to change between the first shape and the second shape.In addition, the far-end of sheath pipe 301 or proximate distal ends can also arrange the flag member for showing sheath pipe 301 under X-ray, in order to avoid when performing the operation, sheath pipe 301 stretches out outside electrode load bearing component 102 too much, thus damage nephridial tissue.
As shown in Figure 6, as a kind of mapping mode of this embodiment, sheath pipe 301 comprises internal layer 302 and outer 303, the material of internal layer 302 is PTFE, wall thickness is 0.015-0.5mm, and coefficient of friction is less, when sheath pipe 301 mainly plays smooth effect relative to during electrode load bearing component 102 relative sliding.The material of outer 303 is Pebax or TPU, can contain 20-40wt%BaSO
4.
As shown in Figure 7, as the another kind of mapping mode of this embodiment, the skin 303 of sheath pipe 301 comprises the first braiding webmaster 313, second and weaves webmaster 323 and the 3rd braiding webmaster 333; The braided wires that first braiding webmaster 313, second weaves webmaster 323 and the 3rd braiding webmaster 333 is Ni-Ti silk.The hardness of the first braiding webmaster 313 is 25 ± 15D, and the hardness of the second braiding webmaster 323 is 35 ± 15D, and the hardness of the 3rd braiding webmaster 333 is 72 ± 15D.The hardness that first braiding webmaster 313, second weaves webmaster 323 different with the 3rd braiding webmaster 333 can be realized by identical weaving manner and different Pebax hardness, also can be realized by identical Pebax hardness and different weaving manners.
In addition, in this specific embodiment, in order to user grips conveniently, pipe guide also comprises the handle 401 being suitable for user and gripping, axial filament 103, transfer unit 201, sheath pipe 301 and shape controlling assembly 402 are installed on handle 401, independently two parts that handle 401 and the connection cord of external energy generator are set to one or are connected by conversion port.Shape controlling assembly 402 extends to the outside of handle 401, the operation of the sheath pipe 301 that carries out pushing and pull back for user.
The foregoing describe provided by the invention for regulating the detailed description of the invention of neural device.Be to be understood that, those of ordinary skill in the art just design according to the present invention can make many modifications and variations without the need to creative work, as long as this adjusting part can be transported to the neural site regulated near needs via blood vessel, and operational shape control assembly makes electrode load bearing component change between the first shape and the second shape, just can realize the object of neuroregulation and treatment.Such as, application number some schemes disclosed by the Chinese patent application of 200780031879.4 and 200980157662.7 can be used for reference and realize this object, provided device specifically can be adopted to drive the motion of shape controlling parts.Therefore, all those skilled in the art, all should by the determined protection domain of claims under this invention's idea on the basis of existing technology by the available technical scheme of logical analysis, reasoning, or a limited experiment.
More than describe preferred embodiment of the present invention in detail.Should be appreciated that the ordinary skill of this area just design according to the present invention can make many modifications and variations without the need to creative work.Therefore, all technical staff in the art, all should by the determined protection domain of claims under this invention's idea on the basis of existing technology by the available technical scheme of logical analysis, reasoning, or a limited experiment.
Claims (10)
1. one kind for regulating neural pipe guide, comprise the adjusting part for regulating described nerve, described adjusting part comprises at least two electrodes for adjusting energy being delivered to described nerve and is used for carrying the electrode load bearing component of described electrode, and described pipe guide also comprises the transfer unit for being transported to by described adjusting part near the position of described nerve and is coated at the sheath pipe of described transfer unit; Described electrode is connected with the wire of the described adjusting energy of conveying;
Described electrode load bearing component has the first shape and the second shape, described pipe guide is configured to: when described sheath pipe slides along described transfer unit and is coated at described adjusting part, described electrode load bearing component is in the first shape, when described sheath pipe departs from described adjusting part, described electrode load bearing component is in the second shape;
Wherein, under described first shape, described adjusting part is applicable to moving in the blood vessel, and the electrode under described second shape on described electrode load bearing component is in the position being applicable to described adjusting energy being delivered to described nerve;
It is characterized in that, described electrode load bearing component comprises axial filament and insulating coating, and described axial filament is positioned at the cavity of described insulating coating, and described electrode sleeve is connected to the outside of described insulating coating.
2. pipe guide according to claim 1, is characterized in that, the first shape of described electrode load bearing component is straight or approximate straight elongate, bar shaped, thread or fibrous.
3. pipe guide according to claim 1, is characterized in that, the second shape of described electrode load bearing component is spiral type or is approximately spiral type.
4. pipe guide according to claim 1, is characterized in that, described wire bonds is in the inner surface of described electrode.
5. the pipe guide according to claim 1 or 4, is characterized in that, described wire enters the cavity of described insulating coating by the opening on described insulating coating.
6. pipe guide according to claim 1, is characterized in that, described sheath pipe comprises internal layer and skin.
7. pipe guide according to claim 6, is characterized in that, the material of described internal layer is PTFE, and internal layer thickness is 0.015-0.5mm.
8. pipe guide according to claim 6, is characterized in that, described outer field macromolecular material is for containing 20-40wt%BaSO
4pebax or TPU.
9. pipe guide according to claim 6, is characterized in that, described skin comprises braiding webmaster.
10. pipe guide according to claim 9, is characterized in that, described braiding webmaster comprises the first braided wires section, the second braided wires section and the 3rd braided wires section.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310662004.1A CN104688331A (en) | 2013-12-09 | 2013-12-09 | Catheter device used for regulating nerves |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310662004.1A CN104688331A (en) | 2013-12-09 | 2013-12-09 | Catheter device used for regulating nerves |
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| Publication Number | Publication Date |
|---|---|
| CN104688331A true CN104688331A (en) | 2015-06-10 |
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| CN201310662004.1A Pending CN104688331A (en) | 2013-12-09 | 2013-12-09 | Catheter device used for regulating nerves |
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| WO2017132935A1 (en) * | 2016-02-04 | 2017-08-10 | 上海安通医疗科技有限公司 | Multi-electrode renal artery ablation catheter |
| CN110353795A (en) * | 2018-04-09 | 2019-10-22 | 乐普（北京）医疗器械股份有限公司 | A kind of multi-pole rf ablation catheter for treating resistant hypertension |
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